Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

ZNF609 HSF1 POLR2A FOXC1

1.17e-0583344GO:1990841
GeneOntologyMolecularFunctionDNA-binding transcription activator activity, RNA polymerase II-specific

SOX15 JUNB SOX21 HSF1 NFIC FOXC1

3.26e-04560346GO:0001228
GeneOntologyMolecularFunctionDNA-binding transcription activator activity

SOX15 JUNB SOX21 HSF1 NFIC FOXC1

3.45e-04566346GO:0001216
GeneOntologyMolecularFunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding

HOXA6 SOX15 JUNB DLX1 SOX21 HSF1 NFIC FOXC1

9.39e-041244348GO:0000978
GeneOntologyMolecularFunctioncis-regulatory region sequence-specific DNA binding

HOXA6 SOX15 JUNB DLX1 SOX21 HSF1 NFIC FOXC1

1.08e-031271348GO:0000987
GeneOntologyMolecularFunctionchromatin binding

SOX15 DLX1 ZNF609 HSF1 POLR2A FOXC1

1.40e-03739346GO:0003682
GeneOntologyCellularComponentchromatin

HOXA6 SOX15 SETD1A JUNB DLX1 SOX21 HSF1 NFIC POLR2A FOXC1

6.29e-0514803310GO:0000785
GeneOntologyCellularComponenteuchromatin

SETD1A HSF1 POLR2A

1.98e-0472333GO:0000791
DomainHMG_box

SOX15 SOX21

3.94e-0353332PF00505
DomainHMG_BOX_2

SOX15 SOX21

4.09e-0354332PS50118
DomainHMG

SOX15 SOX21

4.09e-0354332SM00398
Domain-

SOX15 SOX21

4.24e-03553321.10.30.10
DomainHMG_box_dom

SOX15 SOX21

5.87e-0365332IPR009071
Domain-

DEPTOR HSF1 FOXC1

6.61e-032183331.10.10.10
DomainWHTH_DNA-bd_dom

DEPTOR HSF1 FOXC1

8.80e-03242333IPR011991
DomainHomeobox_metazoa

HOXA6 DLX1

1.10e-0290332IPR020479
Pubmed

Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc.

FERMT2 ACAN

9.28e-07234235013104
Pubmed

Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice.

FERMT2 ACAN

9.28e-07234235788130
Pubmed

A census of human transcription factors: function, expression and evolution.

HOXA6 SOX15 JUNB DLX1 SOX21 HSF1 NFIC FOXC1

2.08e-0690834819274049
Pubmed

Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4CreERT2 versus AggrecanCreERT2 transgene in mice.

FERMT2 ACAN

2.78e-06334237292436
Pubmed

BAF complex is closely related to and interacts with NF1/CTF and RNA polymerase II in gene transcriptional activation.

NFIC POLR2A

5.56e-06434215999204
Pubmed

Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR.

SOX15 SOX21

5.56e-0643429827568
Pubmed

Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.

ITGA1 FOXC1

9.26e-06534222020760
Pubmed

The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling.

SIK3 DEPTOR

9.26e-06534230232230
Pubmed

An atlas of combinatorial transcriptional regulation in mouse and man.

HOXA6 SOX15 JUNB DLX1 EYA2 NFIC POLR2A

1.88e-0587734720211142
Pubmed

SHARPIN is an endogenous inhibitor of β1-integrin activation.

ITGA1 FERMT2

1.94e-05734221947080
Pubmed

An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.

EPN3 ZNF609 NFIC PKP4

2.85e-0518034435198878
Pubmed

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells.

SETD1A POLR2A

3.33e-05934222723415
Pubmed

Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.

SETD1A POLR2A

4.15e-051034217998332
Pubmed

Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules.

PKP4 ITSN2 GAREM1

5.49e-057534315951569
Pubmed

Lsh controls Hox gene silencing during development.

HOXA6 SLC11A1

6.08e-051234217726103
Pubmed

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart.

ACAN FOXC1

6.08e-051234218296617
Pubmed

Deciphering the Sox-Oct partner code by quantitative cooperativity measurements.

SOX15 SOX21

7.19e-051334222344693
Pubmed

Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.

SOX15 SOX21

7.19e-051334212194848
Pubmed

Next-generation sequencing to generate interactome datasets.

JUNB NOL4L SIK3 EYA2 DEPTOR FERMT2 PKP4

1.03e-04114734721516116
Pubmed

Retinoic acid-dependent eye morphogenesis is orchestrated by neural crest cells.

EYA2 FOXC1

1.10e-041634216207763
Pubmed

Transcriptional activators differ in their abilities to control alternative splicing.

NFIC POLR2A

1.10e-041634212221105
Pubmed

Exon structure of the nuclear factor I DNA-binding domain from C. elegans to mammals.

JUNB NFIC

1.10e-041634210087299
Pubmed

Interaction between Foxc1 and Fgf8 during mammalian jaw patterning and in the pathogenesis of syngnathia.

ACAN FOXC1

1.74e-042034224385915
Pubmed

Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.

JUNB POLR2A

1.74e-04203429128241
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

HOXA6 JUNB DLX1 HSF1 NFIC

1.76e-0454434528473536
Pubmed

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.

SOX15 SOX21

1.93e-042134216306355
Pubmed

SOX9 is dispensable for the initiation of epigenetic remodeling and the activation of marker genes at the onset of chondrogenesis.

ACAN FOXC1

1.93e-042134230021842
Pubmed

Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.

TENM2 ACAN

3.21e-042734225133637
Pubmed

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.

TNS1 ACAN

3.70e-042934221998595
Pubmed

Human transcription factor protein interaction networks.

SOX15 SETD1A JUNB NOL4L ZNF609 NFIC FOXC1

3.95e-04142934735140242
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

SETD1A POLR2A

4.24e-043134220516061
Pubmed

c-Jun is required for the specification of joint cell fates.

JUNB ACAN

4.24e-043134223475960
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

ZNF609 EYA2 TNS1 POLR2A PKP4 FOXC1

4.84e-04104934627880917
Pubmed

Ethanol-responsive brain region expression networks: implications for behavioral responses to acute ethanol in DBA/2J versus C57BL/6J mice.

DLX1 PKP4

5.72e-043634215745951
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

JUNB NOL4L HSF1 NFIC POLR2A

8.78e-0477434515302935
Pubmed

The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone Sensitivity in the Fetal Brain.

DLX1 ACAN

8.94e-044534234248495
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

TNS1 NFIC ACAN

9.55e-0419834320881960
InteractionPAX9 interactions

ZNF609 EYA2 KRTAP13-3 NFIC FOXC1

2.12e-06130335int:PAX9
InteractionKMT2D interactions

SOX15 SETD1A EYA2 NFIC POLR2A

7.67e-06169335int:KMT2D
InteractionDTX2 interactions

EPN3 ZNF609 EYA2 KRTAP13-3 NFIC PKP4

1.40e-05330336int:DTX2
InteractionZNF608 interactions

SOX15 SETD1A ZNF609 NFIC

1.57e-0593334int:ZNF608
InteractionNFIX interactions

SOX15 SETD1A ZNF609 NFIC FOXC1

3.18e-05227335int:NFIX
InteractionSIX4 interactions

SOX15 EYA2 NFIC

5.79e-0546333int:SIX4
InteractionSOX15 interactions

SOX15 ZNF609 NFIC FOXC1

8.02e-05141334int:SOX15
InteractionNFIB interactions

SOX15 ZNF609 NFIC FOXC1

8.25e-05142334int:NFIB
InteractionZNF609 interactions

SOX15 ZNF609 EYA2 NFIC

9.19e-05146334int:ZNF609
InteractionBCOR interactions

SOX15 ZNF609 EYA2 NFIC FOXC1

1.23e-04302335int:BCOR
InteractionKDM6A interactions

SOX15 SETD1A EYA2 NFIC

1.37e-04162334int:KDM6A
InteractionGAREM2 interactions

ITSN2 GAREM1

1.42e-0411332int:GAREM2
InteractionPOU2F1 interactions

HOXA6 SOX15 NFIC FOXC1

1.85e-04175334int:POU2F1
InteractionNFIA interactions

SOX15 ZNF609 NFIC FOXC1

2.43e-04188334int:NFIA
InteractionSETD1B interactions

SETD1A ZNF609 POLR2A

2.49e-0475333int:SETD1B
InteractionGATA2 interactions

ZNF609 KRTAP13-3 NFIC FOXC1

3.02e-04199334int:GATA2
InteractionFEV interactions

SETD1A ZNF609 NFIC FOXC1

3.25e-04203334int:FEV
InteractionTLE3 interactions

SOX15 ZNF609 EYA2 NFIC FOXC1

3.40e-04376335int:TLE3
InteractionNFIC interactions

SOX15 ZNF609 NFIC FOXC1

3.70e-04210334int:NFIC
CytobandEnsembl 112 genes in cytogenetic band chr2q24

PKP4 CYTIP

4.02e-03127342chr2q24
CytobandEnsembl 112 genes in cytogenetic band chr2q35

SLC11A1 TNS1

4.14e-03129342chr2q35
GeneFamilySRY-boxes

SOX15 SOX21

2.85e-0419242757
CoexpressionLI_ESTROGENE_EARLY_E2_RESPONSE_UP

KCNK6 SYBU DEPTOR FOXC1

5.09e-0688344M48213
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

JUNB DLX1 TENM2 KRTAP13-3 ACAN POLR2A FOXC1

1.68e-05650347MM1042
CoexpressionMARTINEZ_TP53_TARGETS_DN

JUNB DLX1 TENM2 KRTAP13-3 ACAN POLR2A FOXC1

1.83e-05659347MM1040
CoexpressionGSE37605_TREG_VS_TCONV_NOD_FOXP3_FUSION_GFP_UP

JUNB FERMT2 POLR2A CYTIP

4.18e-05150344M8796
CoexpressionLAKE_ADULT_KIDNEY_C27_VASCULAR_SMOOTH_MUSCLE_CELLS_AND_PERICYTES

JUNB ITGA1 SIK3 TNS1

4.75e-05155344M39246
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

JUNB DLX1 TENM2 ACAN POLR2A FOXC1

1.20e-04610346M3854
CoexpressionMARTINEZ_TP53_TARGETS_DN

JUNB DLX1 TENM2 ACAN POLR2A FOXC1

1.25e-04615346M8673
CoexpressionYAGUE_PRETUMOR_DRUG_RESISTANCE_DN

TNS1 ACAN

1.26e-0413342M2070
CoexpressionGSE18281_PERIMEDULLARY_CORTICAL_REGION_VS_WHOLE_CORTEX_THYMUS_UP

EPN3 ZNF609 DEPTOR POLR2A

1.28e-04200344M7256
CoexpressionGSE411_UNSTIM_VS_100MIN_IL6_STIM_MACROPHAGE_UP

JUNB KCNK6 PKP4 CYTIP

1.28e-04200344M5985
CoexpressionGSE3982_MAST_CELL_VS_BCELL_UP

DEPTOR ZFR2 PKP4 SLC27A2

1.28e-04200344M5434
CoexpressionGSE39110_UNTREATED_VS_IL2_TREATED_CD8_TCELL_DAY3_POST_IMMUNIZATION_UP

KCNK6 EYA2 ZFR2 CYTIP

1.28e-04200344M9278
CoexpressionHALLMARK_ESTROGEN_RESPONSE_EARLY

SYBU DEPTOR FOXC1 SLC27A2

1.28e-04200344M5906
CoexpressionGSE22589_HEALTHY_VS_HIV_INFECTED_DC_UP

SETD1A SLC11A1 DEPTOR NFIC

1.28e-04200344M7805
CoexpressionBUSSLINGER_ESOPHAGEAL_QUIESCENT_BASAL_CELLS

JUNB TNS1 NFIC

1.37e-0477343M40001
CoexpressionNAKAYA_PLASMACYTOID_DENDRITIC_CELL_FLUMIST_AGE_18_50YO_7DY_DN

EPN3 SOX15 SLC11A1 TNS1 ACAN ZFR2 GAREM1

1.40e-04909347M41018
CoexpressionJARDIM_PERASSI_TRIPLE_NEGATIVE_BREAST_CANCER_MOUSE_XENOGRAFT_MELATONIN_DN

EYA2 TENM2

1.47e-0414342MM453
CoexpressionBHAT_ESR1_TARGETS_NOT_VIA_AKT1_UP

KCNK6 SYBU DEPTOR FOXC1

1.57e-04211344M2230
CoexpressionFOROUTAN_PRODRANK_TGFB_EMT_DN

SYBU DEPTOR SLC27A2

1.65e-0482343M42504
CoexpressionSWEET_KRAS_TARGETS_UP

JUNB FERMT2 TNS1

1.71e-0483343M2448
CoexpressionKIM_WT1_TARGETS_UP

JUNB FERMT2 TNS1 FOXC1

1.74e-04217344M9128
CoexpressionLAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM

EYA2 DEPTOR TNS1 TENM2 NFIC

1.89e-04417345M39224
CoexpressionOSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP

JUNB SIK3 FERMT2 PKP4

1.97e-04224344M12383
CoexpressionDUTERTRE_ESTRADIOL_RESPONSE_6HR_UP

KCNK6 SYBU DEPTOR SLC27A2

2.11e-04228344M2151
CoexpressionTOMIDA_METASTASIS_DN

SYBU FOXC1

2.47e-0418342M2583
CoexpressionFOROUTAN_TGFB_EMT_DN

SYBU DEPTOR SLC27A2

3.71e-04108343M42502
CoexpressionFAN_EMBRYONIC_CTX_OLIG

NOL4L SIK3 DEPTOR ACAN PKP4 GAREM1

3.75e-04754346M39037
CoexpressionHE_LIM_SUN_FETAL_LUNG_C1_SMG_CELL

KCNK6 SYBU EYA2 DEPTOR SOX21 FOXC1

4.34e-04775346M45713
CoexpressionHE_LIM_SUN_FETAL_LUNG_C0_ASPN_POS_CHONDROCYTE

EYA2 ACAN FOXC1

4.69e-04117343M45663
CoexpressionHELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_DN

EYA2 DEPTOR NFIC CYTIP

4.72e-04282344M7623
CoexpressionFOROUTAN_INTEGRATED_TGFB_EMT_UP

JUNB FERMT2 TNS1

5.05e-04120343M42505
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB EYA2 TENM2 NFIC POLR2A FOXC1

5.62e-09186346bd1185592aedebccd1007dbf2dd2f549fcdf9f42
ToppCellfacs-Mammary_Gland-Mammary_Gland-21m-Epithelial|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB EYA2 TENM2 NFIC POLR2A FOXC1

6.19e-09189346965e0e388251e7318f8b463816dc96ccb4658677
ToppCellproximal-3-Epithelial-Goblet|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPN3 SYBU EYA2 SOX21 SLC27A2

3.94e-071983453477202c4f702d8f75231b13d4b5216f56d981d7
ToppCellproximal-Epithelial-Goblet|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPN3 SYBU EYA2 SOX21 SLC27A2

3.94e-07198345e7e1c430486a81280abc4a7e7f5bc3713dd20737
ToppCellproximal-Epithelial-Goblet-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

EPN3 SYBU EYA2 SOX21 SLC27A2

3.94e-07198345da7b40eb00bb5e454e1cfcd1219dc0d84712592a
ToppCell10x5'v1-week_12-13-Mesenchymal_osteo-stroma-osteochondral_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DLX1 SYBU ITGA1 FOXC1

1.02e-0517934498c0c5c8034ae8a4b3ceea7fd1d0386ee5f89d09
ToppCelldroplet-Kidney-nan-18m-Epithelial-podocyte|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPN3 EYA2 SOX21 FOXC1

1.09e-051823449fc2f84bf70ad9a11c8a7326bd101e6f6cbcc33e
ToppCell5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SOX15 SLC11A1 FERMT2 TNS1

1.22e-05187344e1b41560c26795a7d353b9468b1bb6fc7c6b379e
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-myofibroblast|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA1 FERMT2 ACAN FOXC1

1.24e-05188344116ca07ee4413dcc0e9e5ac99bfee6ed7b7847c6
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ITGA1 TENM2 ACAN FOXC1

1.27e-05189344975e7aa3b862a8b07c2ab8426a14f5cc54998aca
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPN3 SOX15 EYA2 SOX21

1.29e-0519034447e07ea22733306d8885ee9e5f0b033e2f5e2afb
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

EPN3 SOX15 EYA2 SOX21

1.29e-05190344261b8afddfdcba4f70b50df126cef7ad00a0aae0
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

JUNB ITGA1 ACAN FOXC1

1.29e-05190344a7f6c38bbf451f166febb21e6719d4afced4035e
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 TNS1 PKP4

1.29e-05190344c8370c922e0cf0e0c36e02e1ed2b4053ad6a8073
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 TNS1 PKP4

1.29e-051903445174f91a880f85bb20806023aa68bd4b8ca24ea5
ToppCelldroplet-Fat-BAT+GAT+MAT-30m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 TNS1 PKP4

1.29e-0519034490e494cbfbed33a3a0d29bb7dae83f0c81580bcf
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNS1 TENM2 PKP4 FOXC1

1.32e-05191344297bc79adc5fef211497819b4861b52cd26ac754
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TNS1 TENM2 PKP4 FOXC1

1.32e-05191344e1ec165ba6578cefd88895e7e183190e79f733a4
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_chondroblast_(18)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

EYA2 TENM2 ACAN FOXC1

1.35e-05192344d0649410cf5eacdb0c1dce70e37c7473ef5fddfa
ToppCell5'-Adult-LargeIntestine-Mesenchymal-myocytic|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGA1 FERMT2 TNS1 NFIC

1.38e-05193344146e8c148478ab61b1c1dbaf1ee98a8cd4a0ff8a
ToppCellfacs-BAT-Fat-3m-Endothelial-nan|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 TNS1 PKP4

1.38e-05193344e340064cd146deac03f2d0fd43e2e218bb6057c9
ToppCelldroplet-Fat-Mat-18m-Endothelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FERMT2 TNS1 PKP4 FOXC1

1.38e-0519334454024a373e42e1c0bcc327dc084564b83b63a9d4
ToppCelldroplet-Fat-Mat-18m-Endothelial-endothelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FERMT2 TNS1 PKP4 FOXC1

1.38e-0519334481d908594d2983ba7e7c1ec25afdde4315d9690e
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA1 FERMT2 TNS1 FOXC1

1.38e-0519334488916d9a7d831eb52848599917c04238f8f9812b
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA1 FERMT2 ACAN FOXC1

1.38e-05193344800b0f5705fefcd3608e37801afae8a94474723e
ToppCellfacs-BAT-Fat-3m-Endothelial-endothelial_cell|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 TNS1 PKP4

1.38e-05193344a211b386fd0fb9da9937361d29d90925a72c9715
ToppCellfacs-BAT-Fat-3m-Endothelial|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 TNS1 PKP4

1.38e-051933443086c33f4d6fab66966818737f95ae4d6b2615b0
ToppCelldroplet-Fat-Mat-18m-Endothelial-Cd36+|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FERMT2 TNS1 PKP4 FOXC1

1.40e-0519434474d0eaa76f6d9af14110dfe5b4bf9751b99ff6e3
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon|organoid_Paulsen_bioRxiv / Sample Type, Dataset, Time_group, and Cell type.

JUNB DLX1 FERMT2 NFIC

1.49e-0519734458b957efd006f43c2fe55071d5c6d06c2e367e72
ToppCellcellseq-Epithelial-Epithelial_Airway-Basal/Suprabasal-Suprabasal|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

EPN3 SOX15 EYA2 SOX21

1.52e-051983446e047de63ef59dcb47e4fc06b173b2a02fdcf4c9
ToppCell10x5'v1-week_17-19-Myeloid_neutrophil-granulo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

JUNB SLC11A1 DEPTOR FERMT2

1.55e-05199344a24a319d3ba8f4759f742af27610b4d62e359a2d
ToppCelldistal-Epithelial-Differentiating_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SOX15 EYA2 SOX21 GAREM1

1.55e-05199344286d52f25120293620bdbfd62b832f08e118adf6
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-05200344b5b5a32925f225610fe25a021a742d6397162863
ToppCellLPS_anti-TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-052003449169a9ec8e9ab95d90a64c5a19ac666a5cf82313
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-05200344a3a1e35934d676c39f917652e50c502cb2f613c1
ToppCellLPS_IL1RA-Mesenchymal_myocytic-Pericyte|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-05200344b22cae282591d8dead9869c2adbb9632615f50f7
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-05200344c06426f877919bdd267ea2fd7e7973c6619832ae
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte|LPS_only / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-052003448c8ef2b19ab5b1bfc0fae6c38a330f464f28e86f
ToppCellLPS_only-Mesenchymal_myocytic-Pericyte-Pericyte_3|LPS_only / Treatment groups by lineage, cell group, cell type

ITGA1 TENM2 ACAN FOXC1

1.58e-052003447c62678cf408aaaf98d6df0fb27814d2007c4521
ToppCellCOVID-19_Mild-Neu_4|World / 5 Neutrophil clusters in COVID-19 patients

EPN3 DLX1 ZFR2

1.15e-041243435ef9eb806fb2c8ee5aae0a75503d244b08ee10d4
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|368C / Donor, Lineage, Cell class and subclass (all cells)

POLR2A SLC27A2 CYTIP

1.90e-041473433ed5b020ce1f1277917d79ef1f7da53fa474e8db
ToppCellMyeloid-C_(Monocyte)|World / shred on cell class and cell subclass (v4)

JUNB SLC11A1 CYTIP

2.09e-041523439145dc014ed7f154c158d454dc2b9754396afcca
ToppCell10x5'v1-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEMP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HOXA6 DEPTOR SLC27A2

2.14e-0415334314753baa9980f75206fefc3c8b43685fd4178a43
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ITGA1 TNS1 FOXC1

2.35e-0415834308806240228c5b780f5aef92ce2c278ae4d797cc
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4L SYBU LRRC4

2.35e-0415834312661763d1c309106801cb710c04cd2b62d16cba
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell-SMC-SMC_Acta2|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ITGA1 TNS1 FOXC1

2.35e-04158343496b6988f7b3439968351840ae22f56ffa1643f1
ToppCellfrontal_cortex-Non-neuronal-smooth_muscle_cell-SMC|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ITGA1 TNS1 FOXC1

2.35e-041583435b3d30f92b619f14a7b48502170000fa5783358a
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4L SYBU LRRC4

2.35e-04158343e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4L SYBU LRRC4

2.35e-041583430792c39e6fc0745095af7812de2d50949540d60f
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ITGA1 FERMT2 PKP4

2.53e-04162343465cb483f41023d6125ea147e16f404d8e8dc9bb
ToppCellTCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3|TCGA-Uterus / Sample_Type by Project: Shred V9

EPN3 SYBU SOX21

2.57e-04163343d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SYBU SOX21 SLC27A2

2.57e-0416334322fa5d017ff796394394d952ec151e2d1beb8248
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Keratinizing_Cervical_Squamous_Cell_Carcinoma|TCGA-Cervix / Sample_Type by Project: Shred V9

SOX15 JUNB TENM2

2.62e-04164343de1646dbcf2a10b48e021acf7dc63e803e6a47ce
ToppCellMultiple_Sclerosis-Other-HSPC|Multiple_Sclerosis / Disease, Lineage and Cell Type

HOXA6 DEPTOR SLC27A2

2.62e-041643436af5529507d695b347adee4be5ead70f56c9cf55
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-ILC3|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC11A1 ZFR2 FOXC1

2.62e-04164343631ec9f54475dcc9d6b1c5bf6917e7fda4671034
ToppCell5'-Adult-Appendix-Hematopoietic-T_cells-Activated_CD8_T|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNF609 ITGA1 ZFR2

2.62e-0416434324fdea5113d92b96f56b06dd2449910a3c785e69
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

EPN3 SYBU EYA2

2.76e-041673436efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA6 ITGA1 FOXC1

2.81e-041683433bddf411a60137a8883fc9e77586e4719b0d6067
ToppCelldroplet-Marrow-nan-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF609 DEPTOR CYTIP

2.81e-04168343e979a4fbeb9f21048b47d69e6da75c57650697f2
ToppCellfacs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HOXA6 ITGA1 FOXC1

2.81e-04168343b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DLX1 SYBU ZFR2

2.81e-04168343948d9e9972bd2a4b503d55fa69b70dd568a35a67
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ITGA1 SLC27A2 CYTIP

2.91e-041703439a47d03f7eea6299a836a0eb1e7c1252c03f76df
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK-NK-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ITGA1 SLC27A2 CYTIP

2.91e-041703434252c0a335762508bd1f8f71c6e78a657d7df125
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-NK|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ITGA1 SLC27A2 CYTIP

2.91e-041703430aa11d8cb44403b6769860dac2d3b05da6fff79d
ToppCellPND07-Immune-Immune_Myeloid|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JUNB SLC11A1 CYTIP

2.96e-04171343f68cbfa2eb1f39401a31dbd9b630023249406098
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN4|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB ITGA1 CYTIP

3.01e-04172343d098e8a9c7666354803225cf2650faad436bab66
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA1 FERMT2 TNS1

3.06e-04173343f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCellPND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA1 FERMT2 TNS1

3.06e-04173343cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCelldroplet-Thymus-nan-21m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB ITGA1 CYTIP

3.11e-04174343319bfafc66a21ad05ab35e0fd024c8b372a07165
ToppCellControl-Myeloid-MoAM2,_CCL18|Control / Condition, Lineage and Cell class

EYA2 DEPTOR TNS1

3.11e-041743434c64ff5666812fb4efa440ba4faeca51d916d68e
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Endothelial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NOL4L TENM2 PKP4

3.11e-04174343c58328c2f262506a4518f49f148e29874faf9171
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ITGA1 FERMT2 BEGAIN

3.17e-04175343fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellwk_15-18-Mesenchymal-Chondrocyte-intermediate_chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DEPTOR ACAN FOXC1

3.17e-04175343a84965d28438a4228d841b357c2cd75cf4b59a63
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SOX15 TENM2 PKP4

3.17e-041753439142ed8ca2f1c0c518deb21988221406f62fe38c
ToppCell3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TNS1 ACAN FOXC1

3.22e-0417634390f36f10c6ed440a0ca549f23219398853f1fbc3
ToppCellPND07-Immune|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

JUNB SLC11A1 CYTIP

3.22e-041763432f87f49b64c6f89823d540172a8e923ebaa6d6cd
ToppCellwk_08-11-Mesenchymal-Chondrocyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

EYA2 ACAN FOXC1

3.22e-041763431af28b701c4598ce761f85adbd5d79e4918d265a
ToppCellControl-Myeloid-MoAM2,_CCL18|Myeloid / Condition, Lineage and Cell class

EYA2 DEPTOR TNS1

3.27e-04177343470f54fe2b21c7350ea471e02039461a3808f700
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ITGA1 FERMT2 TNS1

3.27e-04177343452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCelldroplet-Marrow-nan-21m-Myeloid-monocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB SLC11A1 CYTIP

3.27e-04177343b860013f1fd397400a62d66ab521cfc81349ffe2
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGA1 FERMT2 TNS1

3.33e-04178343185b44700f06ec58b3c09c80520502166c965fd6
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_bronchioalveolar_tree|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX15 EYA2 SOX21

3.33e-04178343b89c4d015b44bf538aa39969ef8778877c8023f1
ToppCell3'-Adult-Distal_Rectal-Endothelial-blood_vessel_EC-Mature_arterial_EC|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

FERMT2 FOXC1 ITSN2

3.33e-04178343c30d3390fc4a7856f50ba8ff6694c0333165ddde
ToppCellfacs-Lung-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

SOX15 EYA2 SOX21

3.33e-04178343fb8f8d95f6b08378fb42c4076ee040276faa296f
ToppCellfacs-Heart-RA-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JUNB NFIC FOXC1

3.33e-04178343b505e2550860e777535ee95f29c936242fd607f1
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ITGA1 FERMT2 TNS1

3.38e-04179343e860dca9b28ac5af61804bfd729cd39257cdb352
ToppCellCOVID-19_Mild-Hematopoietic_SC-HSPC|COVID-19_Mild / Disease group, lineage and cell class

HOXA6 DEPTOR SLC27A2

3.38e-0417934319fcf48f5e02e4cb2b328efb4502f337e1282f72
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HOXA6 DEPTOR SLC27A2

3.38e-041793434bb2debfc9e9f258cd38e797ef160bd440aad6af
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HOXA6 DEPTOR SLC27A2

3.38e-041793432f690f933bf6b99abeb31766e0b22bdbe36c1ba0
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HOXA6 DEPTOR SLC27A2

3.38e-041793433e2c937369b8190fd5d5a31689d029e6e89fb5e2
ToppCellCOVID-19_Mild-Hematopoietic_SC|COVID-19_Mild / Disease group, lineage and cell class

HOXA6 DEPTOR SLC27A2

3.38e-0417934350a073166e34bcfa52a62c4dafb3aef724e0fa8e
ToppCellE15.5-Mesenchymal-myocytic_cell-vascular_associated_smooth_muscle_cell|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ITGA1 FOXC1 BEGAIN

3.44e-0418034338035cf2c6fbc443ea10ca7e942572715ed572da
ToppCellmetastatic_Lymph_Node-Myeloid_cells-CD1c+_DCs|Myeloid_cells / Location, Cell class and cell subclass

HOXA6 JUNB KCNK6

3.44e-041803436c0115d03ec58bc7ae5317bf8906617489975351
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HOXA6 DEPTOR SLC27A2

3.50e-04181343e7f7b519c2a01c15f26df11ec9b434c0d1630c7a
ToppCell10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-MEP|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

HOXA6 DEPTOR SLC27A2

3.50e-04181343ee207ea171e2ffc22a7f850be57bb118a87e0f81
ToppCellwk_15-18-Mesenchymal-Chondrocyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

DEPTOR ACAN FOXC1

3.50e-041813438950844b3e65c7028d80da5787ae2ce509c3d52d
ToppCellPBMC-Mild-Hematopoietic-HSPC-HSPC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

HOXA6 DEPTOR SLC27A2

3.50e-0418134354a19cf6a3b752e2391feb8b316bebee0e602d17
ToppCellPBMC-Mild-Hematopoietic-HSPC|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

HOXA6 DEPTOR SLC27A2

3.50e-041813435b84625b1d3737708001b64f6da9360330d39a27
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HOXA6 DEPTOR SLC27A2

3.55e-041823436497eeafb2b137e70261ec0314782831892a940d
ToppCellControl-Epithelial-Basal|World / Disease state, Lineage and Cell class

SOX15 EYA2 FERMT2

3.55e-04182343759390dde9b18757f7675d13d44c89d0e32f8d93
Drug1-phenylbiguanide hydrochloride; Down 200; 10uM; MCF7; HG-U133A

ZNF609 SLC11A1 FERMT2 FOXC1 ITSN2

1.05e-0519734522_DN
DrugDiphenylpyraline hydrochloride [132-18-3]; Up 200; 12.6uM; PC3; HT_HG-U133A

ZNF609 SLC11A1 ACAN PKP4 FOXC1

1.05e-051973454299_UP
DrugFenbendazole [43210-67-9]; Up 200; 13.4uM; PC3; HT_HG-U133A

ZNF609 SOX21 FERMT2 ACAN

1.62e-041853444542_UP
DrugGossypol [303-45-7]; Up 200; 7.8uM; PC3; HT_HG-U133A

ZNF609 FERMT2 ACAN PKP4

1.72e-041883444296_UP
DrugClioquinol [130-26-7]; Up 200; 13uM; HL60; HT_HG-U133A

TNS1 ACAN POLR2A BEGAIN

1.76e-041893443084_UP
DrugFenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; PC3; HT_HG-U133A

HOXA6 ZNF609 SLC11A1 HSF1

1.79e-041903444274_UP
DrugPimozide [2062-78-4]; Down 200; 8.6uM; HL60; HG-U133A

ZNF609 TNS1 PKP4 CYTIP

1.83e-041913441562_DN
DrugHydrocortisone base [50-23-7]; Up 200; 11uM; PC3; HT_HG-U133A

ZNF609 SOX21 HSF1 TNS1

1.86e-041923446684_UP
Drug17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A

JUNB EYA2 FERMT2 POLR2A

1.86e-041923445222_DN
DrugDeltaline [6836-11-9]; Up 200; 7.8uM; PC3; HT_HG-U133A

SLC11A1 HSF1 ACAN BEGAIN

1.90e-041933444306_UP
DrugArtemisinin [63968-64-9]; Up 200; 14.2uM; PC3; HT_HG-U133A

JUNB ZNF609 ITSN2 GAREM1

1.94e-041943447247_UP
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

SETD1A ZNF609 SLC11A1 SOX21

1.94e-041943446171_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; HL60; HT_HG-U133A

JUNB SLC11A1 DEPTOR TNS1

1.94e-041943442672_DN
DrugSkimmianine [83-95-4]; Up 200; 15.4uM; MCF7; HT_HG-U133A

HOXA6 SLC11A1 SOX21 BEGAIN

1.94e-041943446066_UP
DrugSulfathiazole [72-14-0]; Down 200; 15.6uM; PC3; HG-U133A

JUNB ZNF609 SLC11A1 ITSN2

1.98e-041953441883_DN
DrugPiperidolate hydrochloride [129-77-1]; Down 200; 11.2uM; HL60; HT_HG-U133A

ZNF609 SLC11A1 TNS1 PKP4

1.98e-041953446129_DN
DrugLY294002; Down 200; 10uM; MCF7; HG-U133A

SLC11A1 SOX21 NFIC ITSN2

2.02e-04196344328_DN
Drugnordihydroguaiaretic acid; Down 200; 1uM; HL60; HT_HG-U133A

ZNF609 SLC11A1 SOX21 TNS1

2.02e-041963446182_DN
DrugCAY10397; Up 200; 10uM; PC3; HT_HG-U133A

JUNB ZNF609 SLC27A2 GAREM1

2.02e-041963447071_UP
DrugEbselen [60940-34-3]; Down 200; 14.6uM; PC3; HT_HG-U133A

ZNF609 ITGA1 DEPTOR TNS1

2.06e-041973445778_DN
DrugHarmane hydrochloride [21655-84-5]; Up 200; 18.2uM; MCF7; HT_HG-U133A

SOX15 SLC11A1 ACAN BEGAIN

2.06e-041973444408_UP
DrugRapamycin; Up 200; 0.1uM; HL60; HT_HG-U133A

ITGA1 SLC11A1 FOXC1 BEGAIN

2.06e-041973442667_UP
DrugPilocarpine nitrate [148-72-1]; Down 200; 14.8uM; PC3; HT_HG-U133A

HOXA6 JUNB HSF1 TNS1

2.06e-041973446741_DN
DrugIdazoxan hydrochloride [79944-56-2]; Up 200; 16.6uM; HL60; HT_HG-U133A

ZNF609 TNS1 PKP4 GAREM1

2.06e-041973443088_UP
DrugMevalonic-D, L acid lactone [674-26-0]; Up 200; 30.8uM; HL60; HT_HG-U133A

ITGA1 EYA2 SLC11A1 FOXC1

2.06e-041973442718_UP
DrugStachydrine hydrochloride; Up 200; 22.2uM; HL60; HG-U133A

TNS1 NFIC SLC27A2 BEGAIN

2.06e-041973441751_UP
DrugMethylatropine nitrate [52-88-0]; Up 200; 11uM; PC3; HT_HG-U133A

ZNF609 TNS1 SLC27A2 GAREM1

2.06e-041973447253_UP
DrugArecoline hydrobromide [300-08-3]; Up 200; 17uM; HL60; HT_HG-U133A

SETD1A ZNF609 SLC11A1 NFIC

2.06e-041973441303_UP
DrugSR-95639A [115767-94-7]; Up 200; 10uM; PC3; HT_HG-U133A

ZNF609 SOX21 HSF1 TNS1

2.10e-041983446632_UP
Drugsulindac; Down 200; 50uM; MCF7; HG-U133A

SETD1A TNS1 ZFR2 PKP4

2.10e-04198344307_DN
Drugfluphenazine dihydrochloride; Up 200; 10uM; HL60; HT_HG-U133A

ZNF609 SLC11A1 DEPTOR ACAN

2.10e-041983441178_UP
DrugDextromethorphan hydrobromide monohydrate [6700-34-1]; Up 200; 10.8uM; PC3; HT_HG-U133A

ZNF609 DEPTOR TNS1 PKP4

2.10e-041983446300_UP
DrugDipyridamole [58-32-2]; Up 200; 8uM; PC3; HG-U133A

SETD1A ZNF609 NFIC BEGAIN

2.10e-041983441934_UP
DrugFluvoxamine maleate [61718-82-9]; Up 200; 9.2uM; PC3; HT_HG-U133A

HOXA6 SOX15 TNS1 ACAN

2.10e-041983443995_UP
DrugCloperastine hydrochloride [14984-68-0]; Up 200; 11uM; PC3; HT_HG-U133A

EYA2 HSF1 ACAN BEGAIN

2.10e-041983443710_UP
DrugSuramin sodium salt; Down 200; 10uM; PC3; HT_HG-U133A

SETD1A ZNF609 DEPTOR TNS1

2.10e-041983447501_DN
DrugPregnenolone [145-13-1]; Up 200; 12.6uM; HL60; HT_HG-U133A

DEPTOR ACAN PKP4 BEGAIN

2.14e-041993442497_UP
Drugsulindac sulfone; Down 200; 50uM; MCF7; HG-U133A

SETD1A TNS1 PKP4 BEGAIN

2.14e-04199344309_DN
DrugOrlistat; Down 200; 10uM; PC3; HT_HG-U133A

HOXA6 ITGA1 TNS1 FOXC1

2.14e-041993446420_DN
DrugKetorolac tromethamine [74103-07-4]; Up 200; 10.6uM; MCF7; HT_HG-U133A

ZNF609 SYBU SLC11A1 TNS1

2.14e-041993446489_UP
DrugN6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; Up 200; 20uM; MCF7; HG-U133A

ZNF609 NFIC ACAN FOXC1

2.18e-04200344591_UP
Drugnordihydroguaiaretic acid; Up 200; 1uM; HL60; HT_HG-U133A

SETD1A TNS1 FOXC1 GAREM1

2.18e-042003441164_UP
Diseaseforced expiratory volume

SETD1A NOL4L ITGA1 TNS1 ACAN GAREM1

2.54e-04789346EFO_0004314
Diseaseplasminogen activator inhibitor 1 measurement

MUC17 NFIC

1.78e-0354342EFO_0004792
DiseaseFEV/FEC ratio

NOL4L ITGA1 DEPTOR TNS1 NFIC ACAN

2.54e-031228346EFO_0004713
Diseaseerythrocyte measurement

NOL4L ITGA1 TNS1

3.20e-03257343EFO_0005047

Protein segments in the cluster

PeptideGeneStartEntry
GSSKPSPIYISSYSS

PKP4

1086

Q99569
AFPSYAGSLPTSSSY

BEGAIN

286

Q9BUH8
GSPSSYNSSSSSPRY

EPN3

181

Q9H201
SPYISSVQSYPGSAS

DLX1

81

P56177
PYSSSTLPHGSSYSL

ITSN2

181

Q9NZM3
STLITTVGYGYTTPL

KCNK6

101

Q9Y257
SYGASSLPDKTYTSP

HOXA6

41

P31267
GSGPYSAPSPAYSSS

HSF1

236

Q00613
TRSPSPTLSYYSSGL

GAREM1

561

Q9H706
VPTTSTGYQPAYTTS

LRRC4

476

Q9HBW1
SGSSYGSISSPTSPT

SLC11A1

11

P49279
SNGYPVLYPTGLSSS

ITGA1

1011

P56199
TTPESPPYSSGSYDS

NOL4L

126

Q96MY1
SLPSGAYYGSGTPSS

ACAN

1916

P16112
AYYGSGTPSSFPTVS

ACAN

1921

P16112
GAYSPGQSSLYSSPC

FOXC1

351

Q12948
SSGYFSSSPTLSSSP

DEPTOR

286

Q8TB45
GPAYSSYSTLTGSLT

CYTIP

21

O60759
YPGSSCGSSYPSNLV

KRTAP13-3

21

Q3SY46
ITPGSGSIYSSPGLY

FERMT2

171

Q96AC1
GTSIPTSTYTEGSTP

MUC17

321

Q685J3
SSFSTSPTGQSPYTY

EYA2

121

O00167
SSGLPYASSLGYPTA

SOX21

186

Q9Y651
FSTPALYIYTSGTTG

SLC27A2

216

O14975
GSPSSYSPSTGVGFS

SIK3

901

Q9Y2K2
SSSSPGYPLTSGTVY

TENM2

331

Q9NT68
GGDYYTSPSSPTSSS

NFIC

296

P08651
TPYTSRGSTPYSQDS

SETD1A

271

O15047
PSYSTAYLPGSYGSS

SOX15

166

O60248
GQPASTLSSGYTYPT

ZFR2

156

Q9UPR6
SYAPSSPSSSNSGSY

SYBU

221

Q9NX95
TSPTYSPTSPKGSTY

POLR2A

1926

P24928
KGSTYSPTSPGYSPT

POLR2A

1936

P24928
GYSPTSPTYSLTSPA

POLR2A

1946

P24928
YQSSSPLPTVGSSYS

TNS1

1131

Q9HBL0
PLPTVGSSYSSPDYS

TNS1

1136

Q9HBL0
PSSYSFSPYGSKVSG

ZNF609

1261

O15014
AVGTGSSYPTTTISY

JUNB

201

P17275