Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

ABCB1 SLC22A13 SLC23A2 SLC26A9 SLC6A15 GRIK5 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC16A8

2.63e-0720720713GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

ABCB1 SLC22A13 SLC23A2 SLC26A9 SLC6A15 GRIK5 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC16A8

2.78e-0720820713GO:0005342
GeneOntologyMolecularFunctionorganic acid:sodium symporter activity

SLC23A2 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.46e-06352076GO:0005343
GeneOntologyMolecularFunctiontransmembrane transporter activity

ANO9 ABCA3 UQCR10 NDUFV1 CHRNB3 ABCB1 SV2B SLC22A13 KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC26A9 SLC6A15 OCA2 GRIK5 SLC35F1 PKD1L3 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC15A5 SLC45A2 SLC4A4 SLC16A8

1.69e-06118020731GO:0022857
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

ABCB1 SLC22A13 SLC23A2 SLC26A9 SLC6A15 GRIK5 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC4A4 SLC16A8

2.43e-0629320714GO:0008514
GeneOntologyMolecularFunctionamino acid:sodium symporter activity

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

3.30e-06232075GO:0005283
GeneOntologyMolecularFunctiontransporter activity

ANO9 ABCA3 CETP UQCR10 NDUFV1 CHRNB3 ABCB1 SV2B SLC22A13 KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC26A9 SLC6A15 OCA2 GRIK5 SLC35F1 PKD1L3 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC15A5 SLC45A2 SLC4A4 SLC16A8

3.72e-06128920732GO:0005215
GeneOntologyMolecularFunctionsymporter activity

SLC23A2 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC15A5 SLC45A2 SLC4A4 SLC16A8

3.83e-0615020710GO:0015293
GeneOntologyMolecularFunctionamino acid:monoatomic cation symporter activity

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.11e-05292075GO:0005416
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

SLC9B2 SCN8A SLC23A2 SLC6A15 GRIK5 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC4A4

1.22e-0517120710GO:0015081
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A15 GRIK5 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5

1.37e-051052078GO:0015171
GeneOntologyMolecularFunctionsolute:sodium symporter activity

SLC23A2 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC4A4

2.11e-05812077GO:0015370
GeneOntologyMolecularFunctiongamma-aminobutyric acid:sodium:chloride symporter activity

SLC6A6 SLC6A8 SLC6A13

2.15e-0562073GO:0005332
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

ANO9 UQCR10 NDUFV1 CHRNB3 KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC26A9 SLC6A15 OCA2 GRIK5 PKD1L3 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC45A2 SLC4A4

2.74e-0579320722GO:0015075
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC23A2 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC45A2 SLC4A4

3.41e-051192078GO:0015294
GeneOntologyMolecularFunctionactive transmembrane transporter activity

ABCA3 UQCR10 NDUFV1 ABCB1 SLC9B2 SLC23A2 SLC26A9 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC15A5 SLC45A2 SLC4A4 SLC16A8

4.01e-0547720716GO:0022804
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

ANO9 UQCR10 NDUFV1 KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC26A9 SLC6A15 OCA2 GRIK5 PKD1L3 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC45A2 SLC4A4

4.29e-0575820721GO:0015318
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC9B2 SLC23A2 SLC26A9 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC15A5 SLC45A2 SLC4A4 SLC16A8

6.45e-0529620712GO:0015291
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

UQCR10 NDUFV1 CHRNB3 KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC6A15 GRIK5 PKD1L3 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC45A2 SLC4A4

6.59e-0566420719GO:0008324
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

UQCR10 NDUFV1 SLC9B2 SLC23A2 SLC26A9 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC45A2 SLC4A4

7.57e-0530120712GO:0022853
GeneOntologyMolecularFunctiongamma-aminobutyric acid transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A13

8.81e-0592073GO:0015185
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

UQCR10 NDUFV1 KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC6A15 GRIK5 PKD1L3 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC45A2 SLC4A4

9.89e-0562720718GO:0022890
GeneOntologyMolecularFunctioncarbamoyl-phosphate synthase (ammonia) activity

CAD CPS1

1.07e-0422072GO:0004087
GeneOntologyMolecularFunctioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

CAD CPS1

1.07e-0422072GO:0004088
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

KCNJ4 SLC9B2 SCN8A TRPV2 SLC23A2 CACNA1B SLC31A1 SLC6A15 GRIK5 PKD1L3 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC4A4

1.08e-0446520715GO:0046873
GeneOntologyMolecularFunctioncarbon-nitrogen ligase activity, with glutamine as amido-N-donor

CAD CPS1 ASNS

1.25e-04102073GO:0016884
GeneOntologyMolecularFunctionPDZ domain binding

RPS6KB1 SYNJ2 KCNJ4 ARHGAP29 GRIK5 TGFBR3 SNTG2

2.99e-041232077GO:0030165
GeneOntologyMolecularFunctiontaurine:sodium symporter activity

SLC6A6 SLC6A13

3.19e-0432072GO:0005369
GeneOntologyMolecularFunctioniron-responsive element binding

ACO1 IREB2

3.19e-0432072GO:0030350
GeneOntologyMolecularFunctionaconitate hydratase activity

ACO1 IREB2

3.19e-0432072GO:0003994
GeneOntologyMolecularFunctionpolyamine oxidase activity

PAOX IL4I1

3.19e-0432072GO:0046592
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC6A6 SLC6A8 SLC6A13

4.56e-04152073GO:0140161
GeneOntologyMolecularFunctionNADP binding

PGD ME3 CRYZL1 NOS1 HIBADH

4.57e-04622075GO:0050661
GeneOntologyMolecularFunctionolfactory receptor activity

OR5T3 OR9A4 OR1B1 OR4D9 OR7D2 OR4F17 OR4D11 OR52R1 OR52A4P OR10AC1 OR2Y1 OR4B1 OR4A4P

5.88e-0443120713GO:0004984
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor

PAOX IL4I1

6.33e-0442072GO:0016647
GeneOntologyMolecularFunctioncreatine transmembrane transporter activity

SLC6A8 SLC6A13

6.33e-0442072GO:0005308
GeneOntologyMolecularFunctionsodium:chloride symporter activity

SLC6A6 SLC6A8 SLC6A13

6.71e-04172073GO:0015378
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC6A6 SLC6A8 SLC6A13

9.41e-04192073GO:0015355
GeneOntologyMolecularFunctionmonoatomic anion:sodium symporter activity

SLC6A6 SLC6A8 SLC6A13

9.41e-04192073GO:0015373
GeneOntologyMolecularFunctionNAD binding

NDUFV1 ME3 AOX1 HIBADH SIRT2

9.67e-04732075GO:0051287
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

ANO9 SLC26A9 OCA2 SLC6A6 SLC6A8 SLC6A13 SLC4A4

1.02e-031512077GO:0008509
GeneOntologyMolecularFunctionfatty acid omega-1 hydroxylase activity

CYP2C9 CYP2E1

1.05e-0352072GO:0120502
GeneOntologyMolecularFunctionlong-chain fatty acid omega-1 hydroxylase activity

CYP2C9 CYP2E1

1.05e-0352072GO:0120319
GeneOntologyMolecularFunctiontaurine transmembrane transporter activity

SLC6A6 SLC6A13

1.05e-0352072GO:0005368
GeneOntologyMolecularFunctioniron-sulfur cluster binding

ACO1 IREB2 NDUFV1 CIAPIN1 AOX1

1.30e-03782075GO:0051536
GeneOntologyMolecularFunction4 iron, 4 sulfur cluster binding

ACO1 IREB2 NDUFV1 CIAPIN1

1.41e-03472074GO:0051539
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC6A6 SLC6A8 SLC6A13

1.67e-03232073GO:0015377
GeneOntologyMolecularFunctionmetal cluster binding

ACO1 IREB2 NDUFV1 CIAPIN1 AOX1

1.72e-03832075GO:0051540
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

ANO9 SLC26A9 OCA2 SLC6A6 SLC6A8 SLC6A13

1.95e-031252076GO:0015108
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

ANO9 SLC26A9 OCA2 SLC6A6 SLC6A8 SLC6A13 SLC4A4

2.08e-031712077GO:0015103
GeneOntologyMolecularFunctionribosomal protein S6 kinase activity

RPS6KA1 RPS6KB1

2.17e-0372072GO:0004711
GeneOntologyMolecularFunctionalkali metal ion binding

SCN8A CPS1 PDXK

2.39e-03262073GO:0031420
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC6A6 SLC6A8 SLC6A13

2.39e-03262073GO:0015296
GeneOntologyMolecularFunctionmonocarboxylic acid transmembrane transporter activity

SLC22A13 SLC6A6 SLC6A8 SLC6A13 SLC16A8

2.46e-03902075GO:0008028
GeneOntologyMolecularFunctionoxidoreductase activity

CYP2C9 CYP2E1 UQCR10 PGD FMO6P NDUFV1 PTGR3 ME3 PAOX FOXRED2 CRYZL1 IL4I1 NOS1 AOX1 HIBADH PDHX AASS

2.68e-0376620717GO:0016491
GeneOntologyMolecularFunctionneutral L-amino acid:sodium symporter activity

SLC6A15 SLC6A5

2.87e-0382072GO:0005295
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-NH group of donors

PAOX IL4I1 AASS

3.63e-03302073GO:0016645
GeneOntologyMolecularFunctioncell-matrix adhesion mediator activity

ITGA2 ITGA9

3.67e-0392072GO:0098634
GeneOntologyMolecularFunctionsulfur compound transmembrane transporter activity

SLC26A9 SLC3A1 SLC6A6 SLC6A13

3.69e-03612074GO:1901682
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

CYP2C9 HK3 CYP2E1 AMACR ACO1 IREB2 PGD PTGR3 ME3 SLC22A13 IL4I1 NOS1 SLC23A2 ACSL6 CAD ASRGL1 OCA2 PPARG CPS1 HIBADH GBA2 PDHX SLC6A8 SIRT2 AASS ASNS SLC45A2 SLC4A4 ENO1 MMUT ACSL5

3.45e-08103520431GO:0019752
GeneOntologyBiologicalProcessoxoacid metabolic process

CYP2C9 HK3 CYP2E1 AMACR ACO1 IREB2 PGD PTGR3 ME3 SLC22A13 IL4I1 NOS1 SLC23A2 ACSL6 CAD ASRGL1 OCA2 PPARG CPS1 HIBADH GBA2 PDHX SLC6A8 SIRT2 AASS ASNS SLC45A2 SLC4A4 ENO1 MMUT ACSL5

5.67e-08105820431GO:0043436
GeneOntologyBiologicalProcessorganic acid metabolic process

CYP2C9 HK3 CYP2E1 AMACR ACO1 IREB2 PGD PTGR3 ME3 SLC22A13 IL4I1 NOS1 SLC23A2 ACSL6 CAD ASRGL1 OCA2 PPARG CPS1 HIBADH GBA2 PDHX SLC6A8 SIRT2 AASS ASNS SLC45A2 SLC4A4 ENO1 MMUT ACSL5

6.44e-08106420431GO:0006082
GeneOntologyBiologicalProcessorganic acid transmembrane transport

ABCB1 SLC23A2 ACSL6 SLC6A15 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC16A8 ACSL5

1.09e-0716720412GO:1903825
GeneOntologyBiologicalProcesscarboxylic acid transmembrane transport

ABCB1 SLC23A2 ACSL6 SLC6A15 SLC3A1 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC16A8 ACSL5

6.99e-0716320411GO:1905039
GeneOntologyBiologicalProcesscarboxylic acid transport

RPS6KB1 ABCB1 SLC22A13 SLC23A2 ACSL6 SLC26A9 SLC6A15 PPARG SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC16A8 ACSL5

3.47e-0641020416GO:0046942
GeneOntologyBiologicalProcessorganic acid transport

RPS6KB1 ABCB1 SLC22A13 SLC23A2 ACSL6 SLC26A9 SLC6A15 PPARG SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC16A8 ACSL5

3.69e-0641220416GO:0015849
GeneOntologyBiologicalProcesssodium ion transmembrane transport

WNK1 SLC9B2 SCN8A NOS1 SLC23A2 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC4A4

7.49e-0620820411GO:0035725
GeneOntologyBiologicalProcessorganic anion transport

RPS6KB1 ABCB1 SLC22A13 SLC23A2 ACSL6 SLC26A9 SLC6A15 PPARG SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC4A4 SLC16A8 ACSL5

1.55e-0551520417GO:0015711
GeneOntologyBiologicalProcessimport across plasma membrane

WNK1 KCNJ4 TRPV2 CACNA1B ACSL6 SLC31A1 SLC6A6 SLC6A13 SLC7A1 SLC6A5 ACSL5

1.92e-0523020411GO:0098739
GeneOntologyBiologicalProcesssodium ion transport

WNK1 SLC9B2 SCN8A DMPK NOS1 SLC23A2 SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5 SLC4A4

2.00e-0527520412GO:0006814
GeneOntologyBiologicalProcessalpha-amino acid metabolic process

IL4I1 NOS1 CAD ASRGL1 OCA2 CPS1 HIBADH AASS ASNS SLC45A2 MMUT

4.29e-0525120411GO:1901605
GeneOntologyBiologicalProcessproteinogenic amino acid metabolic process

IL4I1 NOS1 CAD ASRGL1 OCA2 CPS1 AASS ASNS SLC45A2

9.74e-051852049GO:0170039
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

CYP2C9 HK3 CYP2E1 AMACR PGD PTGR3 ME3 SLC22A13 IL4I1 ACSL6 PPARG GBA2 PDHX SLC6A8 SIRT2 SLC4A4 ENO1 MMUT ACSL5

1.25e-0473120419GO:0032787
GeneOntologyBiologicalProcesspositive regulation of small molecule metabolic process

NOS1 VCP GPLD1 PPARG SIRT2 SLC4A4 ENO1 SEC14L2 ACSL5

1.29e-041922049GO:0062013
GeneOntologyBiologicalProcesscellular response to iron ion

IREB2 GPLD1 TFR2

1.48e-04112043GO:0071281
GeneOntologyBiologicalProcessimport into cell

MYO7B RPS6KB1 DNER ITGA2 WNK1 SYNJ2 KCNJ4 SLC9B2 TRPV2 NOS1 CACNA1B ACSL6 SLC31A1 POT1 PPARG TFR2 SLC6A6 SLC6A13 SLC7A1 SIRT2 CD9 ITSN2 SLC6A5 ACSL5

1.65e-04107420424GO:0098657
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR5T3 OR9A4 OR1B1 OR4D9 ITGA2 ADGRV1 OR7D2 OR4F17 OR4D11 PKD1L3 OR52R1 OR52A4P OR10AC1 OR2Y1 OR4B1 OR4A4P

2.33e-0458220416GO:0050906
GeneOntologyBiologicalProcessL-amino acid metabolic process

IL4I1 NOS1 CAD ASRGL1 OCA2 CPS1 AASS ASNS SLC45A2

2.35e-042082049GO:0170033
GeneOntologyBiologicalProcessresponse to iron ion

ACO1 IREB2 GPLD1 TFR2

2.37e-04312044GO:0010039
GeneOntologyBiologicalProcessneurotransmitter transport

SV2B NOS1 CACNA1B PPFIA2 SLC6A15 GRIK5 SLC6A6 SLC6A8 SLC6A13 SLC6A5

2.68e-0425920410GO:0006836
GeneOntologyBiologicalProcessprotein localization to chromosome, telomeric region

TCP1 POT1 CCT7 TNKS

2.69e-04322044GO:0070198
GeneOntologyBiologicalProcessmulticellular organismal-level iron ion homeostasis

IREB2 ANK1 TFR2 EPAS1

2.69e-04322044GO:0060586
GeneOntologyBiologicalProcesspositive regulation of long-chain fatty acid import across plasma membrane

ACSL6 ACSL5

2.90e-0432042GO:0010747
GeneOntologyBiologicalProcesschemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

SLIT1 SLIT3

2.90e-0432042GO:0021834
GeneOntologyBiologicalProcesssmall molecule catabolic process

HK3 AMACR OXCT2 PGD SYNJ2 IL4I1 NOS1 ASRGL1 HIBADH AASS ENO1 URAD ACSL5

3.03e-0442120413GO:0044282
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR5T3 OR9A4 OR1B1 OR4D9 OR7D2 OR4F17 OR4D11 PKD1L3 OR52R1 OR52A4P OR10AC1 OR2Y1 OR4B1 OR4A4P

3.53e-0448520414GO:0050907
GeneOntologyBiologicalProcesscirculatory system process

ITGA9 WNK1 ABCB1 SCN8A TMEM65 DMPK NOS1 SLC23A2 CACNA1B PPARG CPS1 ARHGAP35 SLC6A6 TGFBR3 SLC6A13 SLC7A1 SLC4A4 EPAS1

3.75e-0473320418GO:0003013
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR5T3 OR9A4 OR1B1 OR4D9 OR7D2 OR4F17 OR4D11 OR52R1 OR52A4P OR10AC1 OR2Y1 OR4B1 OR4A4P

3.87e-0443220413GO:0050911
GeneOntologyBiologicalProcesssensory perception

OR5T3 OR9A4 OR1B1 MYO7B OR4D9 ITGA2 ADGRV1 OR7D2 SCN8A TRPV2 OR4F17 RBP3 OR4D11 PKD1L3 PKHD1L1 OR52R1 OR52A4P OR10AC1 OR2Y1 SLC45A2 OR4B1 EPAS1 OR4A4P

4.05e-04107220423GO:0007600
GeneOntologyBiologicalProcessorganophosphate metabolic process

SMG1 ABCA3 HK3 CETP OXCT2 PGD NDUFV1 SYNJ2 SLC22A13 PYGL NOS1 VCP GPLD1 ACSL6 CAD CPS1 PDHX PDXK AASS SLC4A4 ENO1 URAD MMUT ACSL5

4.07e-04114220424GO:0019637
GeneOntologyBiologicalProcesspositive regulation of telomere maintenance via telomerase

TCP1 POT1 CCT7 TNKS

4.27e-04362044GO:0032212
DomainNA_NEUROTRAN_SYMP_2

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.08e-06182025PS00754
DomainSNF

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.45e-06192025PF00209
DomainNa/ntran_symport

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.45e-06192025IPR000175
DomainNA_NEUROTRAN_SYMP_1

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.45e-06192025PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.45e-06192025PS50267
DomainLAM_G_DOMAIN

CNTNAP3B CNTNAP3 FAT2 LAMA2 SLIT1 SLIT3

3.07e-06382026PS50025
DomainLaminin_G_2

CNTNAP3B CNTNAP3 FAT2 LAMA2 SLIT1 SLIT3

4.20e-06402026PF02210
DomainLamG

CNTNAP3B CNTNAP3 FAT2 LAMA2 SLIT1 SLIT3

7.45e-06442026SM00282
DomainLaminin_G

CNTNAP3B CNTNAP3 FAT2 LAMA2 SLIT1 SLIT3

3.77e-05582026IPR001791
Domain-

CNTNAP3 ADGRV1 FAT2 LAMA2 NBEA SLIT1 SLIT3

7.71e-059520272.60.120.200
DomainEGF-like_dom

CNTNAP3B DNER CNTNAP3 VWDE FAT2 GP2 FRAS1 LAMA2 SLIT1 SLIT3 MUC3A

8.79e-0524920211IPR000742
DomainCarbamoylP_synth_ssu

CAD CPS1

1.16e-0422022IPR006274
DomainCarbamoylP_synth_lsu

CAD CPS1

1.16e-0422022IPR006275
DomainAconitase/IRP2

ACO1 IREB2

1.16e-0422022IPR006249
DomainCPSase_sm_chain

CAD CPS1

1.16e-0422022SM01097
DomainCPSase_L_D3

CAD CPS1

1.16e-0422022SM01096
DomainCbamoylP_synth_lsu_CPSase_dom

CAD CPS1

1.16e-0422022IPR005483
DomainCarbamoylP_synth_lsu_oligo

CAD CPS1

1.16e-0422022IPR005480
DomainCPSase_sm_chain

CAD CPS1

1.16e-0422022PF00988
DomainPgluconate_DH

PGD HIBADH

1.16e-0422022IPR006183
DomainCPSase_L_D3

CAD CPS1

1.16e-0422022PF02787
Domain-

CAD CPS1

1.16e-04220223.50.30.20
Domain-

CAD CPS1

1.16e-04220221.10.1030.10
DomainCarbamoylP_synth_ssu_N

CAD CPS1

1.16e-0422022IPR002474
DomainEGF

CNTNAP3B DNER CNTNAP3 VWDE FAT2 FRAS1 LAMA2 SLIT1 SLIT3 MUC3A

2.49e-0423520210SM00181
DomainAconitaseA/IPMdHydase_ssu_swvl

ACO1 IREB2

3.47e-0432022IPR000573
DomainAconitase_C

ACO1 IREB2

3.47e-0432022PF00694
DomainTRAM1

TRAM1L1 TRAM2

3.47e-0432022PF08390
Domain-

ACO1 IREB2

3.47e-04320223.30.499.10
DomainMGS-like_dom

CAD CPS1

3.47e-0432022IPR011607
Domain6PGDH_NADP-bd

PGD HIBADH

3.47e-0432022IPR006115
DomainMGS

CAD CPS1

3.47e-0432022PF02142
DomainNAD_binding_2

PGD HIBADH

3.47e-0432022PF03446
DomainAcoase/IPM_deHydtase_lsu_aba

ACO1 IREB2

3.47e-0432022IPR001030
Domain-

ACO1 IREB2

3.47e-04320223.40.1060.10
Domain-

ACO1 IREB2

3.47e-04320223.20.19.10
DomainAcoase/IPM_deHydtase

ACO1 IREB2

3.47e-0432022IPR015937
DomainAcnase/IPM_dHydase_lsu_aba_1/3

ACO1 IREB2

3.47e-0432022IPR015931
DomainAconitase/IPMdHydase_lsu_aba_2

ACO1 IREB2

3.47e-0432022IPR015932
DomainACONITASE_1

ACO1 IREB2

3.47e-0432022PS00450
DomainAconitase/3IPM_dehydase_swvl

ACO1 IREB2

3.47e-0432022IPR015928
DomainAconitase

ACO1 IREB2

3.47e-0432022PF00330
DomainMGS

CAD CPS1

3.47e-0432022SM00851
DomainAconitase_4Fe-4S_BS

ACO1 IREB2

3.47e-0432022IPR018136
Domain-

CAD CPS1

3.47e-04320223.40.50.1380
DomainTranslocation_assoc_membrane

TRAM1L1 TRAM2

3.47e-0432022IPR016447
DomainACONITASE_2

ACO1 IREB2

3.47e-0432022PS01244
DomainTRAM1

TRAM1L1 TRAM2

3.47e-0432022IPR013599
DomainEGF_1

CNTNAP3B DNER CNTNAP3 VWDE FAT2 GP2 LAMA2 SLIT1 SLIT3 MUC3A

4.75e-0425520210PS00022
DomainEGF_2

CNTNAP3B DNER CNTNAP3 VWDE FAT2 GP2 LAMA2 SLIT1 SLIT3 MUC3A

6.40e-0426520210PS01186
DomainConA-like_dom

CNTNAP3B CNTNAP3 ADGRV1 FAT2 NBEAL2 LAMA2 NBEA SLIT1 SLIT3

6.50e-042192029IPR013320
DomainCOE

EBF2 EBF3

6.88e-0442022PS01345
DomainTranscription_factor_COE

EBF2 EBF3

6.88e-0442022IPR003523
DomainCOE_HLH

EBF2 EBF3

6.88e-0442022IPR032201
DomainCOE_DBD

EBF2 EBF3

6.88e-0442022IPR032200
DomainTranscription_factor_COE_CS

EBF2 EBF3

6.88e-0442022IPR018350
DomainCOE1_HLH

EBF2 EBF3

6.88e-0442022PF16423
DomainCOE1_DBD

EBF2 EBF3

6.88e-0442022PF16422
DomainInt_alpha

ITGA2 ITGA9 GPLD1

1.06e-03192023SM00191
DomainInt_alpha_beta-p

ITGA2 ITGA9 GPLD1

1.06e-03192023IPR013519
DomainEGF_3

CNTNAP3B DNER CNTNAP3 VWDE FAT2 GP2 SLIT1 SLIT3 MUC3A

1.07e-032352029PS50026
DomainGATase

CAD CPS1

1.14e-0352022PF00117
DomainCPSASE_1

CAD CPS1

1.14e-0352022PS00866
DomainDUF4704

NBEAL2 NBEA

1.14e-0352022IPR031570
DomainDUF4704

NBEAL2 NBEA

1.14e-0352022PF15787
DomainFG_GAP

ITGA2 ITGA9 GPLD1

1.65e-03222023PS51470
DomainPH_BEACH

NBEAL2 NBEA

1.70e-0362022PF14844
DomainGATASE_TYPE_1

CAD CPS1

1.70e-0362022PS51273
DomainGATASE

CAD CPS1

1.70e-0362022IPR017926
DomainCPSASE_2

CAD CPS1

1.70e-0362022PS00867
DomainFG-GAP

ITGA2 ITGA9 GPLD1

2.13e-03242023PF01839
DomainFG-GAP

ITGA2 ITGA9 GPLD1

2.13e-03242023IPR013517
DomainEGF-like_CS

DNER CNTNAP3 VWDE FAT2 GP2 LAMA2 SLIT1 SLIT3 MUC3A

2.20e-032612029IPR013032
DomainCbamoylP_synth_lsu-like_ATP-bd

CAD CPS1

2.36e-0372022IPR005479
DomainBC-like_N

CAD CPS1

2.36e-0372022IPR005481
DomainQuin_OxRdtase/zeta-crystal_CS

PTGR3 CRYZL1

2.36e-0372022IPR002364
DomainQOR_ZETA_CRYSTAL

PTGR3 CRYZL1

2.36e-0372022PS01162
DomainCPSase_L_D2

CAD CPS1

2.36e-0372022PF02786
DomainBiotin_carb_N

CAD CPS1

2.36e-0372022PF00289
Pubmed

Large-scale proteomics and phosphoproteomics of urinary exosomes.

CETP ACO1 ADGRV1 PGD ABCB1 SLC22A13 GNAI1 VASP VCP TCP1 PPFIA2 AOX1 HUWE1 PKD1L3 PDXK SLC3A1 BROX TGFBR3 SLC6A13 CD9 TLN1 ITSN2 SLC4A4

4.94e-0810162072319056867
Pubmed

The repertoire of solute carriers of family 6: identification of new human and rodent genes.

SLC6A15 SLC6A6 SLC6A8 SLC6A13 SLC6A5

1.34e-0721207516125675
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

MAN2B1 MCM6 WNK1 SEC23B VPS26B USP24 CCT7 HUWE1 CPS1 PDXK TLN1 ASNS ENO1

1.73e-073442071330333137
Pubmed

Neurotransmitter transporter family including SLC6A6 and SLC6A13 contributes to the 5-aminolevulinic acid (ALA)-induced accumulation of protoporphyrin IX and photodamage, through uptake of ALA by cancerous cells.

SLC6A6 SLC6A8 SLC6A13

2.08e-073207324842606
Pubmed

The IRP1-HIF-2α axis coordinates iron and oxygen sensing with erythropoiesis and iron absorption.

ACO1 IREB2 EPAS1

2.08e-073207323395174
Pubmed

IRP1 regulates erythropoiesis and systemic iron homeostasis by controlling HIF2α mRNA translation.

ACO1 IREB2 EPAS1

2.08e-073207323777768
Pubmed

Essential role of systemic iron mobilization and redistribution for adaptive thermogenesis through HIF2-α/hepcidin axis.

ACO1 IREB2 EPAS1

8.28e-074207334593646
Pubmed

Network organization of the huntingtin proteomic interactome in mammalian brain.

CPNE2 RPS6KA1 UQCR10 NDUFV1 PYGL NOS1 VCP ACSL6 ANK1 TCP1 CCT7 GRIK5 HUWE1 SIRT2 CD9 ENO1

1.14e-066212071622794259
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

FAM120B ITGA2 NDUFV1 SBF1 SV2B GNAI1 PLCL1 NOS1 VCP ACSL6 CAD ASRGL1 CARMIL2 TCP1 PPFIA2 RBP3 CCT7 NBEA ARHGAP35 PDHX PDXK SIRT2 TLN1 ITSN2 SLC4A4

1.58e-0614312072537142655
Pubmed

Requirement for Slit-1 and Robo-2 in zonal segregation of olfactory sensory neuron axons in the main olfactory bulb.

SV2B SLIT1 SLIT3 OR2Y1

2.10e-0616207417715346
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

MAN2B1 ACO1 RPS6KA1 IREB2 MCM6 WNK1 PGD BNIP2 CIAPIN1 BUB1B PYGL COG5 VASP SEC23B VCP CUL4A TCP1 POLR1C USP24 CCT7 HUWE1 TRNT1 TLN1 ASNS PARVA

2.13e-0614552072522863883
Pubmed

KCTD9 inhibits the Wnt/β-catenin pathway by decreasing the level of β-catenin in colorectal cancer.

PYGL VCP CAD TCP1 CCT7 TLN1 ENO1

3.12e-06104207736055981
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

MAN2B1 UGT3A1 ME3 PYGL CUL4A AOX1 PPARG PDHX NLRP3 SLC3A1 MMUT

3.15e-063132071120800603
Pubmed

Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.

ABCB1 SLC6A6 SLC7A1 SLC16A8

3.49e-0618207431791063
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

SMG1 ACO1 BTBD1 WNK1 MAP3K5 ARID1B BNIP2 MYO18B VCP LAMA2 TLN1 TNKS ENO1

1.01e-054972071323414517
Pubmed

Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

CYP2C9 CYP2E1 ITGA2 ABCB1 PPARG

1.10e-0549207518936436
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

HK3 AMACR ACO1 IREB2 UQCR10 NDUFV1 PTGR3 ME3 TMEM65 MTRF1L CCT7 CPS1 HIBADH PDHX TRNT1 AASS MMUT ACSL5

1.23e-059262071820877624
Pubmed

MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.

MCM6 PYGL VCP CAD TCP1 CCT7 PDXK ENO1

1.45e-05182207830711629
Pubmed

PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.

PGD VCP TCP1 POLR1C PPARG TLN1

1.70e-0590207630699358
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

FAT2 SLIT1 SLIT3

1.70e-05920739693030
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

HK3 AMACR ACO1 OXCT2 IREB2 UQCR10 NDUFV1 PTGR3 ME3 ABCB1 TMEM65 MTRF1L CCT7 HIBADH PDHX TRNT1 AASS MMUT ACSL5

1.82e-0510472071918614015
Pubmed

Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.

PTGR3 KCNJ4 NOS1 VCP ACSL6 PDHX SLC6A6 TRNT1

2.56e-05197207836604605
Pubmed

Interaction of hydroxylated collagen IV with the von hippel-lindau tumor suppressor.

TCP1 CCT7 EPAS1

3.31e-0511207317339318
Pubmed

Amino acid transport across mammalian intestinal and renal epithelia.

SLC6A15 SLC3A1 SLC6A6 SLC7A1

3.38e-0531207418195088
Pubmed

A regulated RNA binding protein also possesses aconitase activity.

ACO1 IREB2

3.53e-05220721946430
Pubmed

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis.

ACO1 IREB2

3.53e-052207214726953
Pubmed

Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins.

ACO1 IREB2

3.53e-052207217200797
Pubmed

ASK1 inhibition reduces cell death and hepatic fibrosis in an Nlrp3 mutant liver injury model.

MAP3K5 NLRP3

3.53e-052207231996485
Pubmed

Effects of polymorphisms in vitamin E-, vitamin C-, and glutathione peroxidase-related genes on serum biomarkers and associations with glaucoma.

SLC23A2 SEC14L2

3.53e-052207223401652
Pubmed

In vivo role(s) of the iron regulatory proteins (IRP) 1 and 2 in aseptic local inflammation.

ACO1 IREB2

3.53e-052207219533074
Pubmed

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2.

ACO1 IREB2

3.53e-052207215831703
Pubmed

Iron misregulation and neurodegenerative disease in mouse models that lack iron regulatory proteins.

ACO1 IREB2

3.53e-052207225771171
Pubmed

Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.

ACO1 IREB2

3.53e-05220728262972
Pubmed

Linking pharmacovigilance with pharmacogenetics.

CYP2C9 ABCB1

3.53e-052207215588114
Pubmed

Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality.

BUB1B SIRT2

3.53e-052207229067790
Pubmed

Iron regulatory proteins 1 and 2 in human monocytes, macrophages and duodenum: expression and regulation in hereditary hemochromatosis and iron deficiency.

ACO1 IREB2

3.53e-052207216503547
Pubmed

Self-association and ligand-induced conformational changes of iron regulatory proteins 1 and 2.

ACO1 IREB2

3.53e-052207215938636
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

3.53e-052207226807827
Pubmed

Structural and functional analysis of pp70S6k.

RPS6KA1 RPS6KB1

3.53e-05220728524831
Pubmed

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein.

ACO1 IREB2

3.53e-05220722172968
Pubmed

Red meat intake, CYP2E1 and PPARγ polymorphisms, and colorectal cancer risk.

CYP2E1 PPARG

3.53e-052207230489355
Pubmed

Disposition of a CYP2C9 phenotyping agent, losartan, is not influenced by the common 3435C > T variation of the drug transporter gene ABCB1 (MDR1).

CYP2C9 ABCB1

3.53e-052207218816302
Pubmed

Analysis of chaperonin-containing TCP-1 subunits in the human keratinocyte two-dimensional protein database: further characterisation of antibodies to individual subunits.

TCP1 CCT7

3.53e-05220728982604
Pubmed

Mitochondrial dysfunction/NLRP3 inflammasome axis contributes to angiotensin II-induced skeletal muscle wasting via PPAR-γ.

PPARG NLRP3

3.53e-052207231857693
Pubmed

Dysregulation of CLOCK gene expression in hyperoxia-induced lung injury.

CLOCK NLRP3

3.53e-052207224696144
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

3.53e-052207231150793
Pubmed

Reversal of P-glycoprotein-mediated multidrug resistance in SGC7901/VCR cells by PPARgamma activation by troglitazone.

ABCB1 PPARG

3.53e-052207220556576
Pubmed

CYP2C9*3(1075A>C), MDR1 G2677T/A and MDR1 C3435T are determinants of inter-subject variability in fluvastatin pharmacokinetics in healthy Chinese volunteers.

CYP2C9 ABCB1

3.53e-052207222941809
Pubmed

Excess capacity of the iron regulatory protein system.

ACO1 IREB2

3.53e-052207217604281
Pubmed

Involvement of CUL4A in regulation of multidrug resistance to P-gp substrate drugs in breast cancer cells.

ABCB1 CUL4A

3.53e-052207224368600
Pubmed

Oxidative Stress Orchestrates MAPK and Nitric-Oxide Synthase Signal.

RPS6KA1 NOS1

3.53e-052207233228180
Pubmed

Activation of the NLRP3 Inflammasome Is Associated with Valosin-Containing Protein Myopathy.

VCP NLRP3

3.53e-052207227730320
Pubmed

[A new, rapid and robust genotyping method for CYP2C9 and MDR1].

CYP2C9 ABCB1

3.53e-052207212805007
Pubmed

[Reversal of multidrug resistance of gastric cancer cells by down-regulation of CIAPIN1 with CIAPIN1 siRNA].

ABCB1 CIAPIN1

3.53e-052207218389626
Pubmed

Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo.

ACO1 IREB2

3.53e-052207215604406
Pubmed

Subcellular localization of iron regulatory proteins to Golgi and ER membranes.

ACO1 IREB2

3.53e-052207216144863
Pubmed

Electron tomography of degenerating neurons in mice with abnormal regulation of iron metabolism.

ACO1 IREB2

3.53e-052207215866737
Pubmed

SLC45A2 mutation frequency in Oculocutaneous Albinism Italian patients doesn't differ from other European studies.

OCA2 SLC45A2

3.53e-052207224096233
Pubmed

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity.

RPS6KA1 RPS6KB1

3.53e-05220729560223
Pubmed

Peroxisome proliferator-activated receptor γ prevents the production of NOD-like receptor family, pyrin domain containing 3 inflammasome and interleukin 1β in HK-2 renal tubular epithelial cells stimulated by monosodium urate crystals.

PPARG NLRP3

3.53e-052207226238426
Pubmed

The association of aberrant expression of NLRP3 and p-S6K1 in colorectal cancer.

RPS6KB1 NLRP3

3.53e-052207231757663
Pubmed

Iron regulatory proteins secure mitochondrial iron sufficiency and function.

ACO1 IREB2

3.53e-052207220674864
Pubmed

Genetic association of NOS1 exon18, NOS1 exon29, ABCB1 1236C/T, and ABCB1 3435C/T polymorphisms with the risk of Parkinson's disease: A meta-analysis.

ABCB1 NOS1

3.53e-052207227749554
Pubmed

TIPE2 sensitizes osteosarcoma cells to cis-platin by down-regulating MDR1 via the TAK1- NF-κB and - AP-1 pathways.

ABCB1 TNFAIP8L2

3.53e-052207230114619
Pubmed

SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation.

OCA2 SLC45A2

3.53e-052207232966160
Pubmed

The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation.

ACO1 IREB2

3.53e-05220728041788
Pubmed

Generation of conditional alleles of the murine Iron Regulatory Protein (IRP)-1 and -2 genes.

ACO1 IREB2

3.53e-052207216283625
Pubmed

Iron regulatory proteins 1 and 2 have opposing roles in regulating inflammation in bacterial orchitis.

ACO1 IREB2

3.53e-052207238301068
Pubmed

Deletion of iron regulatory protein 1 causes polycythemia and pulmonary hypertension in mice through translational derepression of HIF2α.

ACO1 EPAS1

3.53e-052207223395173
Pubmed

Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response.

PPARG ACSL5

3.53e-052207217495181
Pubmed

Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo.

ACO1 IREB2

3.53e-052207215208438
Pubmed

Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice.

ABCB1 CLOCK

3.53e-052207218773899
Pubmed

Iron regulatory protein 1 outcompetes iron regulatory protein 2 in regulating cellular iron homeostasis in response to nitric oxide.

ACO1 IREB2

3.53e-052207221566147
Pubmed

Deacetylation of the mitotic checkpoint protein BubR1 at lysine 250 by SIRT2 and subsequent effects on BubR1 degradation during the prometaphase/anaphase transition.

BUB1B SIRT2

3.53e-052207225285631
Pubmed

The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia.

CETP ABCB1

3.53e-052207216002074
Pubmed

The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2.

ACO1 EPAS1

3.53e-052207220354189
Pubmed

Genetic polymorphism of the iron-regulatory protein-1 and -2 genes in age-related macular degeneration.

ACO1 IREB2

3.53e-052207222331484
Pubmed

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

ACO1 IREB2

3.53e-05220727983023
Pubmed

Iron transport through ferroportin is induced by intracellular ascorbate and involves IRP2 and HIF2α.

IREB2 EPAS1

3.53e-052207224394537
Pubmed

PLCL1 regulates fibroblast-like synoviocytes inflammation via NLRP3 inflammasomes in rheumatoid arthritis.

PLCL1 NLRP3

3.53e-052207235820936
Pubmed

Iron regulatory proteins increase neuronal vulnerability to hydrogen peroxide.

ACO1 IREB2

3.53e-052207218655771
Pubmed

Effects of iron regulatory protein regulation on iron homeostasis during hypoxia.

ACO1 IREB2

3.53e-052207212855587
Pubmed

Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease.

NLRP3 SIRT2

3.53e-052207228970254
Pubmed

Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase.

AMACR SLC45A2

3.53e-052207234505419
Pubmed

Diurnal control of iron responsive element containing mRNAs through iron regulatory proteins IRP1 and IRP2 is mediated by feeding rhythms.

ACO1 IREB2

3.53e-052207238773499
Pubmed

Circadian expression of Glycoprotein 2 (Gp2) gene is controlled by a molecular clock in mouse Peyer's patches.

GP2 CLOCK

3.53e-052207232050049
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

ANGPT4 PYGL DNAH5 VCP CACNA1B TCP1 CCT7 TLN1

3.77e-05208207833230847
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

SCN8A ANK1 TCP1 PPFIA2 PCDHB12 SLC26A9 NBEA GRIK5 HUWE1 SLC6A6 RANBP3L TLN1 ASNS OR4B1 ZNF304

3.91e-057362071529676528
Pubmed

Blood-Brain Barrier: From Physiology to Disease and Back.

ABCB1 LAMA2 SLC6A6 SLC6A13 SLC7A1 SLC4A4

4.08e-05105207630280653
Pubmed

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

MCM6 ADGRV1 BTBD1 PGD PYGL VCP CUL4A CAD TCP1 CCT7 HUWE1 ENO1

4.63e-054952071228581483
Pubmed

Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies.

CYP2C9 CYP2E1 CETP BCHE ABCB1 PPARG

4.78e-05108207619956635
Pubmed

Genetic susceptibility to distinct bladder cancer subphenotypes.

CYP2C9 CYP2E1 CETP AMACR ABCB1 SLC23A2 POT1 OCA2 PPARG TNKS SEC14L2

4.94e-054212071119692168
Pubmed

Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics.

NDUFV1 S100A11 PYGL GNAI1 VCP TCP1 CCT7 HUWE1 CPS1 TLN1 ENO1

5.04e-054222071127342126
Pubmed

A Large-scale genetic association study of esophageal adenocarcinoma risk.

CYP2C9 CYP2E1 ITGA2 ABCB1 BUB1B ZNF624 ASCC3 SLC23A2 HUS1B PPARG

5.32e-053512071020453000
Pubmed

LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.

MCM6 BTBD1 NDUFV1 FOXRED2 ASCC3 COG5 VCP POLR1C USP24 SLC6A15 APLP2 HUWE1 URGCP SLC7A1 TLN1 ASNS PUM1

5.44e-059422071731073040
Pubmed

Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders.

SCN8A ANK1 OCA2 SLC6A5 SLC45A2

7.20e-0572207525917818
Pubmed

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

CPNE2 MAN2B1 CETP ACO1 PGD ABCB1 S100A11 PYGL VCP GP2 GPLD1 TCP1 BROX CD9 TLN1 ENO1 SEC14L2 CPNE7

8.02e-0510702071823533145
Pubmed

HIV-host interactome revealed directly from infected cells.

VCP CAD CARMIL2 TCP1 CCT7 HUWE1 SLIT1

8.15e-05172207727375898
Pubmed

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.

CYP2E1 NOS1 PPARG CLOCK NLRP3

8.21e-0574207526332085
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

CHRNB3 ABCB1 NOS1 NBEA GRIK5 ARHGAP35 PDXK SLC6A13 SLC6A5

8.53e-05300207919086053
GeneFamilySolute carriers

SLC22A13 SLC9B2 SLC23A2 SLC31A1 SLC26A9 SLC6A15 SLC35F1 SLC3A1 SLC6A6 SLC6A8 SLC6A13 SLC7A1 SLC6A5 SLC15A5 SLC45A2 SLC4A4 SLC16A8

3.58e-0939513017752
CoexpressionCHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP

CYP2E1 AMACR GNAI1 ACSL6 AOX1 HIBADH SLC4A4 SEC14L2 ACSL5

9.18e-061752029M16496
CoexpressionBROWNE_HCMV_INFECTION_20HR_DN

ACO1 ME3 MAP3K5 BUB1B TGFBR3 TNKS TRAM2

1.45e-051022027M5601
CoexpressionGSE29618_PRE_VS_DAY7_FLU_VACCINE_BCELL_DN

LSM5 MTRF1L ANK1 RTF2 CCT7 ARHGAP35 SIRT2 TRAM2 EPAS1

2.27e-051962029M4973
CoexpressionGSE10240_IL17_VS_IL17_AND_IL22_STIM_PRIMARY_BRONCHIAL_EPITHELIAL_CELLS_DN

CPNE2 ABCA3 FOXRED2 SV2B SCN8A PLCL1 ARHGAP35 NLRP3 SLIT3

2.55e-051992029M312
CoexpressionGSE21670_STAT3_KO_VS_WT_CD4_TCELL_DN

LRFN2 SLC9B2 TMEM65 POLR1B PLCL1 CAD SLC7A1 BAZ1A ENO1

2.55e-051992029M7454
CoexpressionRODRIGUES_NTN1_TARGETS_DN

WNK1 ARID1B DMPK VASP CUL4A ENC1 CLOCK CTSE

3.71e-051612028M11857
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

LSM5 SYNJ2 BUB1B ARHGAP29 GNAI1 ASCC3 COG5 SLC23A2 ENC1 USP24 ARHGAP35 CLOCK TGFBR3 SLC7A1 BAZ1A ITSN2 TNKS TRAM2 PUM1

3.82e-0585620219M4500
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 MYO7B ADGRV1 CHRNB3 CACNA1B FRAS1 PPFIA2 LAMA2 CPS1 PKHD1L1 AASS

2.55e-1016020711c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTS19 MYO7B ADGRV1 CHRNB3 CACNA1B FRAS1 PPFIA2 LAMA2 CPS1 PKHD1L1 AASS

2.55e-101602071125c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7B ADGRV1 DNAH5 FRAS1 ANK1 PPFIA2 SLC35F1 CPS1 PKHD1L1 SLC4A4

1.63e-08184207102cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7B ADGRV1 DNAH5 FRAS1 ANK1 PPFIA2 SLC35F1 CPS1 PKHD1L1 SLC4A4

1.63e-08184207102b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO7B ADGRV1 DNAH5 FRAS1 ANK1 PPFIA2 SLC35F1 CPS1 PKHD1L1 SLC4A4

1.63e-0818420710ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DNER ADGRV1 WNK1 ME3 PLCL1 NOS1 GP2 PPFIA2 USP24 RANBP3L

2.10e-0818920710f51cdc9a47371cab8ed9ae63a6f14da07ede446c
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CNTNAP3 ADGRV1 S100A11 PYGL NOS1 VASP AOX1 CPS1 PKD1L3 MUC3A

2.83e-081952071019853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CNTNAP3 ADGRV1 S100A11 PYGL NOS1 VASP AOX1 CPS1 PKD1L3 MUC3A

2.83e-0819520710d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SYNJ2 SV2B SLIT1 SLIT3 SNTG2 SLC4A4

1.52e-071772079bde307e67ad8e48a5ff4c0827015f4688f6b3e46
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SYNJ2 SLC6A15 SLIT1 SLIT3 SNTG2 SLC4A4

1.76e-071802079b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS19 CNTNAP3B CNTNAP3 ABCB1 SYNJ2 SV2B SLIT1 SLIT3 SNTG2

1.84e-07181207908f44323bf71b6004a921bbc969c954c75feeb66
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA3 CYP2E1 AMACR ACO1 UGT3A1 SLC3A1 SLC6A13 AASS SLC4A4

1.93e-071822079faf0dfa3adc2d2706b6942b5127093ccdc856447
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA3 CYP2E1 AMACR ACO1 UGT3A1 SLC3A1 SLC6A13 AASS SLC4A4

1.93e-071822079be8dd52898525ce6632af0adc2801944f3ac10bd
ToppCelldroplet-Marrow-nan-21m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 HK3 MAN2B1 PGD CRLF2 S100A11 PYGL VASP CD9

2.02e-07183207971ea92cd20683230af314ff883b2624bd68382e1
ToppCellCOVID-19-lung-Vein_EC|lung / Disease (COVID-19 only), tissue and cell type

CNTNAP3B ABCB1 ARHGAP29 NOS1 ASRGL1 PKHD1L1 TGFBR3 SNTG2 EPAS1

2.54e-071882079d582b76fc2faac526c9bf97503041129e1a6a211
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CNTNAP3B CNTNAP3 ITGA9 SV2B ARHGAP29 PKHD1L1 SLC7A1 CD9 SNTG2

2.66e-07189207955a1776a4ce049959b3f13a43744c7314bc1f00a
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ITGA2 WNK1 ME3 PLCL1 NOS1 GP2 PPFIA2 USP24 RANBP3L

2.78e-071902079b94df372bc08de11585b2467dba8c8fffff5cd92
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DNER WNK1 GNAI1 PLCL1 NOS1 GP2 ACSL6 SLC6A8 RANBP3L

3.93e-071982079688b0eb5534dde40b8630ab8a3252c816711e02e
ToppCellLPS_only-Hematopoietic_Myeloid|LPS_only / Treatment groups by lineage, cell group, cell type

HK3 PGD S100A11 NBEAL2 PYGL VASP APLP2 NLRP3 ACSL5

4.10e-07199207920523dee39a4c5f6423259920f108127b47525c4
ToppCellCOVID-19-kidney-Lymphatic_EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B CNTNAP3 ITGA9 SV2B OR7D2 PKHD1L1 SNTG2 URAD

4.76e-071482078f777aa1674e898e2594b2b7c029d3d05dda04df9
ToppCelldroplet-Lung-LUNG-1m-Myeloid-neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 HK3 PGD S100A11 PYGL VASP NLRP3 SLC6A13

7.82e-07158207830cceb73cf5e24b692da84d33342fd3b1ad5efe5
ToppCelldroplet-Lung-LUNG-1m-Myeloid-Neutrophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPNE2 HK3 PGD S100A11 PYGL VASP NLRP3 SLC6A13

7.82e-07158207847793463640f98ee5f680a1ee5786b453355fd57
ToppCelldroplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2E1 PYGL GPLD1 AOX1 TFR2 SLC6A13 ASNS SLC4A4

8.60e-071602078c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ABCB1 LRFN2 SYNJ2 ENC1 GRIK5 TGFBR3 SLIT1 SLIT3

2.00e-061792078747a32460b257fffca30527b56a74720eb9c12e4
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SYNJ2 SV2B SLIT1 SNTG2 SLC4A4

2.00e-0617920787954c0026754ab869b88ab7feb13c2f27d6e272d
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B CNTNAP3 ABCB1 ARHGAP29 NOS1 ASRGL1 SNTG2 EPAS1

2.08e-06180207827e8bbee388e64dd79d70b160b76d45b1f398006
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B MYO7B UGT3A1 ABCB1 AOX1 SLC3A1 SLC6A13 SLC4A4

2.08e-061802078864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellCOVID-19-kidney-Stressed_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B MYO7B UGT3A1 ABCB1 AOX1 SLC3A1 SLC6A13 SLC4A4

2.17e-0618120786980ea624151da32b7f537f263e40fcb87a02e81
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRV1 PLCL1 NOS1 GP2 PPFIA2 HIBADH RANBP3L NINL

2.35e-06183207831ab55d5f3639f5964541d5eae23044dbda3356e
ToppCellControl-Endothelial_cells-Pulmonary_venous_endothelial_cells|Control / group, cell type (main and fine annotations)

CNTNAP3B ABCB1 NOS1 ASRGL1 PKHD1L1 TGFBR3 SNTG2 EPAS1

2.35e-06183207846be9f96755c7b65aeac061d95d15abeb6466034
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRV1 PLCL1 NOS1 GP2 PPFIA2 HIBADH RANBP3L NINL

2.55e-061852078898a093757f86be3e18d2ef1f16a71f50ef81dc3
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein|Children_(3_yrs) / Lineage, Cell type, age group and donor

CNTNAP3B CNTNAP3 ABCB1 ARHGAP29 NOS1 ASRGL1 SNTG2 EPAS1

2.76e-061872078e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCellCOVID-19-Endothelial_cells-Pulmonary_venous_endothelial_cells|COVID-19 / group, cell type (main and fine annotations)

CNTNAP3B ABCB1 ARHGAP29 NOS1 ASRGL1 PKHD1L1 SNTG2 EPAS1

2.76e-0618720782d20193a6cacdfa4877457c97b0077408942186c
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

CNTNAP3B MYO7B ACO1 UGT3A1 ABCB1 AOX1 SLC6A13 SLC4A4

2.76e-061872078acd305475f3609800af0d7bc68d83ef41228080b
ToppCellCOVID-19-lung-Artery_EC|lung / Disease (COVID-19 only), tissue and cell type

CNTNAP3B ITGA9 SYNJ2 ARHGAP29 NOS1 ASRGL1 SNTG2 EPAS1

2.87e-061882078eecd7482b3c97d7f49993cb17edfab30c61232fc
ToppCellEndothelial-endothelial_cell_of_lymph_vessel|World / Lineage, Cell type, age group and donor

CNTNAP3B CNTNAP3 ITGA9 SV2B ARHGAP29 PKHD1L1 SLC7A1 SNTG2

2.87e-06188207880910dcbb51990f2baed240f319456c0d3fa2065
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.0.4|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

HK3 ACO1 RPS6KA1 S100A11 TRPV2 IL4I1 VASP TNFAIP8L2

2.99e-0618920786cdd743bc46e34dc48288dda343309131b6c2d5f
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DNER ITGA2 WNK1 NOS1 GP2 PPFIA2 RANBP3L ENO1

2.99e-06189207855420853f730b433ef58ac9337ac84ac78a247a0
ToppCellIPF-Epithelial-Club|Epithelial / Disease state, Lineage and Cell class

DRAM1 ITGA9 MAP3K5 ARHGAP29 MS4A15 CTSE EPAS1 ACSL5

3.36e-061922078356e7a820b744a0ac87352a8d0e6e8d9fa9ed7d2
ToppCellIPF-Endothelial-VE_Venous|IPF / Disease state, Lineage and Cell class

CNTNAP3B ABCB1 ARHGAP29 ASRGL1 PKHD1L1 TGFBR3 SNTG2 EPAS1

3.49e-06193207829a655fa80feaabe846c90a28363b037e22d24ae
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|Classical_Monocyte / Disease condition and Cell class

PGD PYGL RTF2 APLP2 PPARG TLN1 SLC45A2 ENO1

3.91e-06196207815397ec27167bb2fb6fec120b68bf38fc71b2670
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

AMACR LRFN2 SV2B GP2 SLC26A9 PKD1L3 SLC6A5 SLC45A2

3.91e-06196207895544097577f20ed7f4144bd940471cde0617554
ToppCellCOVID-19_Mild-Classical_Monocyte-cMono_3|COVID-19_Mild / Disease condition and Cell class

PGD PYGL RTF2 APLP2 PPARG TLN1 SLC45A2 ENO1

3.91e-061962078f245e929a286cb097130572e1027b4f01be8b04d
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CNTNAP3B CNTNAP3 ITGA9 SV2B PPARG PKD1L3 PKHD1L1 SNTG2

4.22e-061982078fc4b7c3ad52bc5c8b40fa04a156bfbb58afa2872
ToppCellBronchial-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CNTNAP3B CNTNAP3 ITGA9 SV2B PPARG PKD1L3 PKHD1L1 SNTG2

4.22e-061982078b3a020522e064bb61949d38e442f24026e339364
ToppCellSevere_COVID-19-Myeloid-MoAM3|Severe_COVID-19 / Disease group,lineage and cell class (2021.01.30)

PGD S100A11 VASP APLP2 PPARG PDXK TLN1 ENO1

4.38e-06199207830523cf08815ca214877e33a2c52197ff8318557
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PGD S100A11 VASP APLP2 PPARG PDXK TLN1 ENO1

4.38e-061992078b2dc3d0af6ecd3ab01779aaa1f061cb0f941cae8
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PGD S100A11 VASP APLP2 PPARG PDXK TLN1 ENO1

4.38e-061992078105709b97c55826a852aed27658e3b4af1738c8a
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PGD S100A11 VASP APLP2 PPARG PDXK TLN1 ENO1

4.38e-0619920780892957a49304ce4b6daa3657d76d8365ce0dd19
ToppCellBAL-Severe-Myeloid-MoAM-MoAM3-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PGD S100A11 VASP APLP2 PPARG PDXK TLN1 ENO1

4.38e-061992078961ad44199871be8e09d31904d383edc865ba262
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HK3 MAN2B1 RPS6KA1 PGD S100A11 IL4I1 PDXK ENO1

4.54e-0620020785f1de1f9305e1784c12d526f6c8bdd7d56229f9b
ToppCellLPS_only-Hematopoietic_Myeloid-Granulocytic_cells-Neutrophils|LPS_only / Treatment groups by lineage, cell group, cell type

HK3 PGD S100A11 NBEAL2 PYGL VASP APLP2 ACSL5

4.54e-0620020783504aeba7b30cac9c428ba3871c072e2202752b4
ToppCellLPS_only-Hematopoietic_Myeloid-Granulocytic_cells|LPS_only / Treatment groups by lineage, cell group, cell type

HK3 PGD S100A11 NBEAL2 PYGL VASP APLP2 ACSL5

4.54e-062002078c5afebbc16024c60e84a67be81c78b0bfb73ec68
ToppCellChildren_(3_yrs)-Epithelial-basal_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ITGA2 ITGA9 VWDE FAT2 MGAM2 FRAS1 SLC4A4

4.86e-06143207728e936c298a45f88d14f0146caf3d5a22d483cd5
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Erythroid|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

HK3 ACSL6 TNFAIP8L2 ANK1 NLRP3 TFR2 CTSE

5.08e-0614420777c471e332f87d60f4dbed01f3e66bf39995218d0
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

AMACR OXCT2 EBF2 EBF3 SLC6A15 BAZ1A SLC6A5

6.09e-061482077a261c6d3d9cf0311c053fca66c37d39e66db6ad8
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-IPC_like-IPs_and_early_cortical_neurons|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

AMACR OXCT2 EBF2 EBF3 SLC6A15 BAZ1A SLC6A5

6.09e-061482077c0237ba7d4040b6a497094b362dfb8b3a97a7d06
ToppCellfacs-Liver-Hepatocytes|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACO1 BCHE GPLD1 CPS1 TFR2 SLC6A13 SLC4A4

8.60e-061562077e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

ADGRV1 ITGA9 PLCL1 DNAH5 GPLD1 MS4A15 CTSE

9.74e-0615920778680b054622f573a82b1625fb93c2d5db81d1034
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRV1 GNAI1 PLCL1 NOS1 GP2 PPFIA2 RANBP3L

1.01e-05160207703b88dc7ad41c6ae443cab7e77ec666340bf432e
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMACR UGT3A1 VILL SLC22A13 SLC6A15 SLC3A1 SLC6A13

1.10e-0516220776972d45f4bd4b6522bf93295f7e9dca7c6cba1f3
ToppCelldroplet-Liver-Hepatocytes-21m-Epithelial-Hepatocyte_(Pericentral,_Midlobular,_Periportal)|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 BCHE SLC3A1 TFR2 AASS SLC4A4 SEC14L2

1.19e-05164207790afae3cca108ebfb44ff2ec4adcbb8c68a0bdf2
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PYGL CPA5 LAMA2 CAMK1G PPARG AASS SLIT3

1.19e-051642077b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2-AF2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B1 INSRR FMO6P EBF2 ANGPT4 SLC6A15 SLIT3

1.24e-0516520774e13fccd32029e2879e85f8966e582a46c09e4aa
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B ITGA9 ABCB1 PLCL1 EBF3 PPARG EPAS1

1.29e-0516620778e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAN2B1 INSRR FMO6P EBF2 ANGPT4 SLC6A15 SLIT3

1.34e-051672077fe3338f99f94c0dac37e3d649dfdce82e4a56022
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AMACR UGT3A1 VILL SLC22A13 SLC6A15 SLC3A1 SLC6A13

1.39e-05168207735ce3b2b9c9997d4c101da5949c7271d6a6b8f12
ToppCellImmune_cells-Neutrophils|Immune_cells / Lineage and Cell class

CPNE2 HK3 PGD S100A11 PYGL VASP CD9

1.39e-0516820773539f802fe0143da1462df0618f78f9f15143f71
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAP3K5 ANTXR2 SYNJ2 LAMA2 SLIT3 SLC15A5 TRAM2

1.50e-05170207703044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MAP3K5 ANTXR2 SYNJ2 LAMA2 SLIT3 SLC15A5 TRAM2

1.50e-051702077fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SYNJ2 TRPV2 PLCL1 PPFIA2 HIBADH SLIT3 SLC4A4

1.50e-0517020775570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLCL1 LAMA2 NBEA CAMK1G PPARG SLIT3 EPAS1

1.50e-051702077876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLCL1 LAMA2 NBEA CAMK1G PPARG SLIT3 EPAS1

1.50e-0517020771f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCelldroplet-Kidney-nan-3m-Epithelial-epithelial_cell_of_proximal_tubule|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA3 CYP2E1 AMACR UGT3A1 VILL SLC3A1 AASS

1.56e-05171207705fcc72df50a380a913821b5781d9621df37d328
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ABCA3 CYP2E1 AMACR UGT3A1 VILL SLC3A1 AASS

1.56e-05171207748fc4eca18b102b5ec5050f758281292ee8e10c6
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B ITGA9 ASRGL1 SLC6A15 PKHD1L1 SIRT2 EPAS1

1.62e-051722077c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3 LRFN2 SYNJ2 SV2B ENC1 SLIT1 SLIT3

1.75e-051742077bc978a2148a0261a4f9d1ca5479b707e224566be
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SLIT1 SLIT3 SNTG2 SLC4A4

1.75e-051742077321c6cae614d28feeee266eeb3499f2053ab79e0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SLIT1 SLIT3 SNTG2 SLC4A4

1.81e-05175207790e29945aa861082c94bb4f331161adc3a6ef899
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CYP2E1 AMACR UGT3A1 UQCR10 HIBADH AASS SLC4A4

1.81e-05175207713843bfc8efe7c01f19ebb6735609c1eec09c698
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ANK1 PPARG TGFBR3 SLIT1 SLC4A4

1.81e-0517520779d797888edb39fd12fd9cfc698a42b7bed19a5b5
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CPNE2 ITGA9 TRPV2 HUS1B TGFBR3 RANBP3L ACSL5

1.81e-05175207790302e8a44858ef3b2a165b88284d4788d591a99
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122|Adult / Lineage, Cell type, age group and donor

ADGRV1 ITGA9 PLCL1 DNAH5 GPLD1 MS4A15 AASS

1.88e-0517620773fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SYNJ2 SLIT3 PARVA SNTG2

1.88e-05176207772a2a01618ce836bc843395d5095e9090759b4a6
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SLIT1 SLIT3 SNTG2 SLC4A4

1.88e-051762077e4b21fd6a5e0c5950f27c3e1868318e48330ae5e
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTS19 CNTNAP3B CNTNAP3 ABCB1 SV2B SLIT3 SNTG2

1.95e-0517720774c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC2_(MADCAM1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ANO9 ABCA3 CETP ITGA9 ARHGAP29 SLC26A9 SLC7A1

1.95e-051772077d6596a0b6fd146fefc27717c1a7dbaa3774cc644
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3 SYNJ2 SV2B ENC1 SLIT1 SLIT3 SNTG2

1.95e-051772077f30d757ee8db7e10d547498dab6560473c6ed7c0
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SYNJ2 SLIT1 SLIT3 SNTG2

2.02e-051782077431e7557b8e8764e16e9e48368ce6bfa3c61561a
ToppCell10x5'v1-week_17-19-Lymphocytic_NK-T_NK-ILC_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ANO9 CYP2E1 DNER ABCB1 IL4I1 CPS1 EPAS1

2.10e-051792077d18a520568cf4b031972d3dd7d4d4bd073ac1fea
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3 SYNJ2 SV2B ENC1 SLIT1 SLIT3 SNTG2

2.10e-0517920771ac79c82c52fa95bb4e170ab20fec0f648db2134
ToppCell3'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CETP ARHGAP29 SLC26A9 PKHD1L1 SLC7A1 CD9 SNTG2

2.10e-0517920771c0c0647a111f691dae55f4ed8c51006059ce020
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B CNTNAP3 ABCB1 SLIT1 SLIT3 SNTG2 SLC4A4

2.10e-051792077f65889bf1e41396979cce44a5e63f49dea2bbd9b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SYNJ2 SV2B ENC1 SLC35F1 SLIT1 SLIT3 SNTG2

2.10e-051792077445eeb0356d9fd894aa33dd9f45d893b21424149
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DNER ADGRV1 GNAI1 PLCL1 GP2 USP24 RANBP3L

2.17e-0518020779e09b3dfe344b5d50520711513d389865d73a861
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3 SYNJ2 SV2B ENC1 SLIT1 SLIT3 SNTG2

2.25e-0518120779de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 GPLD1 CPS1 SLC3A1 TFR2 SLC6A13 SLC4A4

2.33e-05182207777ab860e2add49dad0c1ffbfc64278ad499dfbd5
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 GPLD1 CPS1 SLC3A1 TFR2 SLC6A13 SLC4A4

2.33e-0518220774921c7d5687cc79f896b39753bb621d7e3d2972f
ToppCellfacs-Liver-Hepatocytes-24m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UGT3A1 GPLD1 CPS1 SLC3A1 TFR2 SLC6A13 SLC4A4

2.33e-051822077770ce9f3f4538d0181a0181543841bc964c68274
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRFN2 SYNJ2 SV2B ENC1 SLIT1 SLIT3 SNTG2

2.33e-05182207735b2a5625323bf0917214d3b82fafc4a8f5e75ff
Drug4-methylpyrazole

CYP2C9 CYP2E1 RPS6KA1 RPS6KB1 IREB2 ACSL6 AOX1 SLC45A2 ACSL5

6.43e-08842049CID000003406
Drugglutamate

HK3 ACO1 DNER OXCT2 IREB2 PGD NDUFV1 CHRNB3 ME3 ABCB1 TRPV2 NOS1 GPLD1 CACNA1B CAD GRIK5 CPS1 PKD1L3 PDHX SLC3A1 SLC6A13 AASS ASNS SLC6A5 SLC4A4 MMUT SEC14L2

1.52e-0796220427CID000000611
Drugammonia

DNER BCHE ITGA2 ME3 PAOX NOS1 CACNA1B CAD ASRGL1 SLC26A9 OCA2 CPS1 PKD1L3 GBA2 PDHX ASNS SLC4A4 ENO1 SEC14L2

1.81e-0750920419CID000000222
Drugguaiazulene

CYP2C9 CYP2E1 ABCB1 SIRT2 SLC45A2

3.12e-07172045CID000003515
Drugcobalt-60

MAN2B1 ACO1 DNER IREB2 ITGA2 PTGR3 GPLD1 CACNA1B TNFAIP8L2 CPA5 LAMA2 GRIK5 PKD1L3 GBA2 TFR2 MMUT

5.10e-0739020416CID000061492
Drugglycolamide

BCHE ITGA2 PAOX

7.09e-0732043CID000069021
Drugdoxorubicinol

ACO1 IREB2 ABCB1 PLCL1 SLC45A2

1.62e-06232045CID000083970
Drugbeta-NADP

CYP2C9 HK3 CYP2E1 ACO1 IREB2 PGD FMO6P NDUFV1 PTGR3 ME3 PYGL CRYZL1 NOS1 HIBADH PDHX AASS ENO1

2.23e-0649020417CID000000929
DrugAC1Q68Z5

HK3 ACO1 OXCT2 IREB2 PGD ME3 PAOX POLR1B POLR1C CPS1 PDHX SIRT2 ASNS MMUT SEC14L2

2.29e-0638620415CID000000181
Drugglyoxylate

ACO1 OXCT2 IREB2 BCHE PGD ME3 PAOX PYGL PDHX MMUT

4.46e-0617620410CID000000760
Drugbeta-alanine

DRAM1 PAOX CAD CPS1 SLC3A1 SLC6A6 SLC6A13 SLC6A5

4.47e-061042048CID000000239
Drugracemethorphan

CYP2C9 CYP2E1 ABCB1 DMPK OCA2 GRIK5 PDHX SLC45A2

5.53e-061072048CID000003008
Drug5,7-dimethoxyflavone

CYP2C9 ABCB1 CD9 SLC45A2

5.84e-06142044CID000088881
Drugp-nitroacetanilide

ACO1 IREB2 DMPK

7.00e-0652043CID000007691
Drugmethylmalonate semialdehyde

PGD AOX1 HIBADH PDHX ASNS

9.09e-06322045CID000000296
Drughydroxyl radicals

CYP2C9 HK3 CYP2E1 ACO1 DNER BCHE ITGA2 FMO6P ABCB1 PAOX SYNJ2 PLCL1 DMPK NOS1 GPLD1 CAD ASRGL1 CPA5 AOX1 RBP3 SLC26A9 APLP2 CPS1 HIBADH PDHX SLC7A1 AASS ASNS ENO1

9.72e-06134120429CID000000961
Drugcarbamyl-L-aspartate

CAD ASRGL1 CPS1 SLC6A6

1.05e-05162044CID000000279
Drugclopidogrel

CYP2C9 ITGA2 ABCB1 S100A11 VASP SLC3A1

1.07e-05562046ctd:C055162
Drughydroxylamine

CYP2C9 ACO1 DNER OXCT2 IREB2 ITGA2 MAP3K5 NOS1 CCT7 PDHX ASNS

1.35e-0524420411CID000000787
Drugbetaine

DNER OXCT2 WNK1 SLC23A2 PDHX SLC3A1 SLC6A6 SLC6A13 SLC6A5 MMUT

1.37e-0520020410CID000000247
DrugBo 4

ITGA2 VASP CACNA1B

1.39e-0562043CID000177595
Drugcubane

ACO1 OXCT2 IREB2 ITGA2 DMPK

1.90e-05372045CID000136090
DrugAmiodarone

CYP2C9 MAN2B1 CYP2E1 ACO1 RPS6KB1 WNK1 PGD CHRNB3 ABCB1 TRPV2 ZNF624 PYGL GPLD1 ACSL6 FRAS1 CAD ANK1 ENC1 RBP3 LAMA2 PPARG ARHGAP35 TFR2 SLC6A6 TRNT1 ASNS SNTG2 SLC4A4 ENO1 MMUT

2.02e-05146920430ctd:D000638
Drugallyl alcohol

CYP2E1 NOS1 CPS1 AASS SLC45A2 MMUT

2.34e-05642046CID000007858
DrugIvermectin

ABCA3 CYP2C9 CYP2E1 ABCB1 TCP1 EBF3 URGCP

2.37e-05952047ctd:D007559
DrugRotenone

ACO1 RPS6KB1 MCM6 MAP3K5 ABCB1 S100A11 SV2B KCNJ4 BUB1B CRYZL1 IL4I1 ASRGL1 ENC1 CAMK1G PPARG NLRP3 SLC3A1 SLC6A6 SLC6A8 CD9 TLN1 ASNS EPAS1

2.43e-0597820423ctd:D012402
Drugmuramic acids

ACO1 INSRR IREB2 MMUT

2.71e-05202044CID000092864
Drugcarnitine

HK3 CYP2E1 OXCT2 PYGL TNFAIP8L2 PPARG CPS1 HIBADH PDHX MMUT SEC14L2

2.90e-0526520411CID000000085
DrugChlorine

AMACR INSRR ABCB1 SV2B KCNJ4 GNAI1 NOS1 VCP CACNA1B SLC6A15 ARHGAP35 SLC7A1 CD9

2.90e-0536720413ctd:D002713
Drugpyruvic acid

HK3 ACO1 OXCT2 IREB2 BCHE PGD NDUFV1 ME3 PYGL CAD PDHX AASS ENO1 SLC16A8

3.10e-0542420414CID000001060
Drugdiosmin

CYP2C9 CYP2E1 ABCB1 SLC45A2

3.32e-05212044CID005281613
DrugC04226

ACO1 IREB2 PGD

3.84e-0582043CID000151255
Drugdilithium tetraborate

WNK1 VASP ENC1

3.84e-0582043CID006336545
DrugCHEBI:38548

BCHE ABCB1 VCP

3.84e-0582043CID016126809
Drug3-methylitaconate

ACO1 IREB2 PGD

3.84e-0582043CID006438940
Drug3-mercaptopropionic acid

ADGRV1 DNAH5 PDHX PDXK SLC6A13

4.49e-05442045CID000006514
Drugnitrosonium

ACO1 IREB2 ITGA2 NOS1 TFR2

4.49e-05442045CID000084878
DrugABT-418

CHRNB3 DMPK CACNA1B AOX1

4.85e-05232044CID000119380
Drugglycogen

HK3 RPS6KA1 RPS6KB1 ADGRV1 PGD ME3 KCNJ4 PYGL PPARG GBA2 PDHX SLC3A1 AASS SLC45A2

4.98e-0544320414CID000439177
Drugdecamethrin

CYP2C9 CYP2E1 KLHL32 PGD SCN8A CACNA1B CAMK1G PPARG

5.30e-051462048ctd:C017180
Drugvinylidene chloride

CYP2E1 MYO7B AMACR ACO1 UQCR10 ME3 S100A11 SYNJ2 PYGL GNAI1 PLCL1 VASP ASRGL1 ENC1 AOX1 SLC6A15 NBEA SLC35F1 PPARG HIBADH SLC3A1 TFR2 SLC7A1 RANBP3L AASS TLN1 ASNS NINL MMUT

5.58e-05147520429ctd:C029297
DrugNSC750266

CYP2C9 CYP2E1 SLC6A5

5.72e-0592043CID000002819
DrugFerrosanol

ACO1 IREB2 TFR2

5.72e-0592043CID000028366
DrugAC1L8B0O

OXCT2 ABCB1 SLC45A2

5.72e-0592043CID000324941
Drugomeprazole sulfone

CYP2C9 CYP2E1 SLC45A2 MMUT

5.78e-05242044CID000145900
Drugsuccinate

HK3 ACO1 OXCT2 IREB2 NDUFV1 ME3 ABCB1 CAD PDHX AASS ENO1 MMUT

5.94e-0533920412CID000001110
Drugglycerol

CYP2C9 HK3 ACO1 BCHE MCM6 ADGRV1 WNK1 LSM5 ME3 PYGL GPLD1 CAD AOX1 PPARG PDHX SLC3A1 SIRT2 PARVA TNKS ENO1

5.99e-0582920420CID000000753
Drugpyridine

CYP2E1 ITGA2 PGD ME3 DMPK AOX1 HIBADH SLC6A13 SIRT2 TNKS

6.27e-0523920410CID000001049
Drugaspartate

ACO1 OXCT2 BCHE WNK1 ME3 CAD ASRGL1 DHX40 GRIK5 CPS1 PDHX SLC3A1 SLC6A6 ASNS CTSE

7.20e-0551820415CID000000424
DrugFusidic acid sodium salt [751-94-0]; Up 200; 7.4uM; PC3; HT_HG-U133A

CETP EBF2 ANGPT4 SLC23A2 GPLD1 ARHGAP35 SLC3A1 PARVA SLC4A4

7.20e-0519620496754_UP
Drugguanethidine

CYP2E1 BCHE CHRNB3 DMPK NOS1 CACNA1B SLC45A2

7.24e-051132047CID000003518
Drugcitrullin

ACO1 NOS1 CAD CPS1 SLC7A1 AASS ENO1 SEC14L2

7.38e-051532048CID000000833
DrugImidurea [39236-46-9]; Up 200; 10.4uM; PC3; HT_HG-U133A

ABCA3 CYP2C9 PAOX GP2 FRAS1 GRIK5 ARHGAP35 PARVA SLC45A2

7.78e-0519820495062_UP
DrugNSC73306

ABCB1 SLC31A1

7.99e-0522042ctd:C511311
DrugBurgess reagent

ABCB1 CD9

7.99e-0522042CID002724994
Drug1-amino-4-chloroanthraquinone

ABCB1 CD9

7.99e-0522042CID000017884
Drugtert-butylphenyl diphenyl phosphate

BCHE PPARG

7.99e-0522042ctd:C046393
Drug4-chloroacetophenone

ITGA2 MMUT

7.99e-0522042CID000007467
Drugdeoxyshikonin

ABCB1 CD9

7.99e-0522042CID000098914
Drugp-nitrophenylhydroxylamine

ACO1 IREB2

7.99e-0522042CID005486551
Drugthiobenzamide

CYP2E1 FMO6P AOX1 SLC45A2

8.02e-05262044CID000683563
Drugmonomethyl phthalate

DNER OXCT2 DMPK SLC23A2 ARHGAP35 HIBADH SLC3A1 ENO1

8.09e-051552048CID000020392
DrugAC1L9KLK

ITGA2 PGD AOX1

8.12e-05102043CID000447216
Drugtissue factor pathway inhibitor (TFPI

CYP2C9 CYP2E1 BCHE

8.12e-05102043CID000038003
Drug2,4-dimethylphenol

CYP2E1 DMPK AOX1

8.12e-05102043CID000007771
DrugAcetylcysteine

CYP2E1 AMACR RPS6KB1 IREB2 BCHE ITGA2 PGD MOAP1 MAP3K5 ABCB1 S100A11 PYGL GP2 PPARG NLRP3 MSGN1 SLC6A6 ASNS EPAS1

8.12e-0578020419ctd:D000111
Drughippuric acid

CYP2E1 SLC23A2 CPS1 GBA2 SEC14L2

8.39e-05502045CID000000464
DrugMyosmine [532-12-7]; Up 200; 27.4uM; MCF7; HT_HG-U133A

CYP2E1 SCN8A DMPK GP2 GPLD1 LAMA2 OCA2 HUWE1 SLC6A6

8.41e-0520020494759_UP
Drugvaldecoxib; Up 200; 10uM; MCF7; HT_HG-U133A

CYP2C9 AMACR SYNJ2 PLCL1 GPLD1 TFR2 SLC6A6 SLC7A1 ZNF304

8.41e-0520020496403_UP
Drugphenylacetic acid

OXCT2 BCHE AOX1 PPARG CPS1 SLC4A4 SEC14L2

8.55e-051162047CID000000999
Drugoxalate

DNER OXCT2 PYGL IL4I1 SLC23A2 SLC26A9 PDHX SLC3A1

9.25e-051582048CID000000971
Drugnifedipine

CYP2C9 CYP2E1 ACO1 IREB2 ABCB1 DMPK CACNA1B GRIK5 PKD1L3 NLRP3 TFR2 ZNF335 SLC45A2

1.01e-0441520413CID000004485
Drugalpha-ketoglutarate

HK3 ACO1 OXCT2 IREB2 PGD PTGR3 ME3 PDHX AASS SEC14L2

1.04e-0425420410CID000000051
Drug4-nitrobiphenyl

AMACR AOX1 SLC45A2 SLC4A4

1.08e-04282044CID000007114
Drugdesethylamodiaquine

CYP2C9 ABCB1 SLC45A2

1.11e-04112043CID000122068
Drug1,4-dinitrobenzene

ACO1 IREB2 ITGA2

1.11e-04112043CID000007492
Drugacetoacetate

HK3 CYP2E1 OXCT2 NDUFV1 HIBADH PDHX MMUT

1.17e-041222047CID000000096
Drugsodium

DNER BCHE WNK1 NDUFV1 ANTXR2 KCNJ4 SLC9B2 DMPK SLC23A2 ASRGL1 SLC26A9 SLC6A15 GRIK5 HUWE1 PDXK SLC3A1 SLC6A6 SLC6A13 SLC7A1 SLC6A5 SLC4A4

1.22e-0494420421CID000000923
Drugprobenecid

ABCA3 CYP2C9 ABCB1 SLC22A13 TRPV2 SLC23A2 CD9

1.24e-041232047CID000004911
Drugarabinopyranose

HK3 MAN2B1 PGD NDUFV1 PYGL APLP2 PPARG GBA2 NLRP3 TGFBR3

1.30e-0426120410CID000000229
Drugammonium sulfate

HK3 PGD PYGL ASRGL1 AOX1 GBA2 PDXK

1.44e-041262047CID000024538
Drugmagnesium

HK3 MAN2B1 OXCT2 BCHE ITGA2 ADGRV1 ITGA9 WNK1 ABCB1 ANTXR2 KCNJ4 POLR1B DNAH5 NOS1 GPLD1 CAD LAMA2 CCT7 GRIK5 CPS1 ARHGAP35 GBA2 PDHX PDXK TRNT1 ENO1

1.44e-04132520426CID000000888
DrugQuinidine

CYP2C9 CYP2E1 ABCB1 HIBADH ASNS

1.45e-04562045ctd:D011802
DrugPhosphoryl

HK3 RPS6KA1 BCHE NDUFV1 BNIP2 GPLD1 PDHX PDXK ENO1

1.46e-042152049CID006857426
Drugj1-2

ACO1 ITGA2 DMPK

1.47e-04122043CID005288652
Drug5'-deoxypyridoxal

OXCT2 PYGL PDXK

1.47e-04122043CID000164889
Drug4-hydroxytoremifene

CYP2E1 PPARG SLC7A1

1.47e-04122043CID003035198
DrugCcris 3504

CYP2E1 PAOX AOX1

1.47e-04122043CID000107874
Druggabapentin

ACO1 IREB2 ABCB1 CACNA1B GRIK5 PKD1L3 TFR2 SLC6A13

1.47e-041692048CID000003446
DrugCO(2

DNER PGD ME3 KCNJ4 NOS1 ANK1 OCA2 CPS1 HIBADH PDHX SLC4A4 ENO1

1.66e-0437820412CID000000280
Drugmalate

HK3 ACO1 OXCT2 IREB2 PGD NDUFV1 ME3 HIBADH PDHX

1.67e-042192049CID000000525
DrugIbuprofen

CYP2C9 AMACR ABCB1 PYGL NOS1 ACSL6 PPARG PKHD1L1 SLC6A8 SLC7A1 ASNS ENO1 EPAS1

1.69e-0443720413ctd:D007052
DrugAC1NE3MZ

ACO1 DNER IREB2 MAP3K5 KCNJ4 NOS1

1.70e-04912046CID004636047
DrugGsts

CYP2C9 CYP2E1 MAP3K5 ABCB1 SV2B CD9 SLC45A2 SLC4A4

1.73e-041732048CID000128079
Drugoxygen

CYP2C9 CYP2E1 ACO1 DNER IREB2 ADGRV1 FMO6P PAOX NOS1 EVC2 AOX1 PDXK TFR2 EPAS1

1.74e-0449920414CID000000977
DrugOmeprazole

CYP2C9 MAN2B1 CYP2E1 ACO1 ABCB1 PYGL GPLD1 ENC1 SLC6A6 CTSE ENO1 MMUT

1.87e-0438320412ctd:D009853
Drugpyrazinoic acid

ACO1 IREB2 SLC22A13

1.90e-04132043CID000001047
DrugAC1L18GM

CYP2C9 CYP2E1 AOX1

1.90e-04132043CID000000092
Drug5-hydroxyvalerate

OXCT2 ZNF331 SLC6A5

1.90e-04132043CID000025945
Drug2-cresol

CYP2E1 BCHE PPARG

1.90e-04132043ctd:C034047
Diseaseresponse to docetaxel trihydrate

SLIT1 SLIT3

4.39e-0521962GO_1902519
Diseasecarbamoyl phosphate synthetase I deficiency disease (implicated_via_orthology)

CAD CPS1

4.39e-0521962DOID:9280 (implicated_via_orthology)
DiseaseDrug-Induced Liver Disease

CYP2C9 CYP2E1 MAP3K5 ABCB1 S100A11 PYGL CPS1 AASS PUM1 CTSE ENO1

8.92e-0540419611C0860207
DiseaseChemical and Drug Induced Liver Injury

CYP2C9 CYP2E1 MAP3K5 ABCB1 S100A11 PYGL CPS1 AASS PUM1 CTSE ENO1

8.92e-0540419611C4277682
DiseaseDrug-Induced Acute Liver Injury

CYP2C9 CYP2E1 MAP3K5 ABCB1 S100A11 PYGL CPS1 AASS PUM1 CTSE ENO1

8.92e-0540419611C3658290
DiseaseHepatitis, Toxic

CYP2C9 CYP2E1 MAP3K5 ABCB1 S100A11 PYGL CPS1 AASS PUM1 CTSE ENO1

8.92e-0540419611C0019193
DiseaseChemically-Induced Liver Toxicity

CYP2C9 CYP2E1 MAP3K5 ABCB1 S100A11 PYGL CPS1 AASS PUM1 CTSE ENO1

8.92e-0540419611C4279912
DiseaseHepatitis, Drug-Induced

CYP2C9 CYP2E1 MAP3K5 ABCB1 S100A11 PYGL CPS1 AASS PUM1 CTSE ENO1

8.92e-0540419611C1262760
DiseaseRS-10-hydroxywarfarin to RS-warfarin ratio measurement

ACSL6 FRAS1 CAMK1G SLC35F1 PARVA MUC3A

9.61e-051101966EFO_0803335
Diseasesleep apnea measurement

ARID1B NOS1 ANK1 NBEA MS4A15 SLC45A2

1.29e-041161966EFO_0007817
DiseaseX-25420 measurement

CPS1 SLC6A13

1.31e-0431962EFO_0800926
DiseaseApnea

BCHE SLC6A5

1.31e-0431962C0003578
Diseaseamino acid measurement

ADAMTS19 CNTNAP3 ITGA2 GNAI1 MGAM2 GRIK5 CPS1 HIBADH SLC6A13 SLIT1 SLIT3 PARVA SLC6A5 EPAS1

1.90e-0467819614EFO_0005134
Diseasefibrinogen measurement, plasminogen activator inhibitor 1 measurement

PPARG CPS1 PKD1L3 NLRP3

2.27e-04451964EFO_0004623, EFO_0004792
DiseaseNerve Degeneration

KCNJ4 NOS1 APLP2 PPARG CD9

2.34e-04831965C0027746
DiseaseAlzheimer's disease (is_implicated_in)

IREB2 BCHE NOS1 PPARG CLOCK ENO1

2.60e-041321966DOID:10652 (is_implicated_in)
Diseasesuntan, skin pigmentation

OCA2 SLC45A2

2.61e-0441962EFO_0003784, EFO_0004279
DiseaseTreacher Collins syndrome

POLR1B POLR1C

2.61e-0441962cv:C0242387
Diseasealcoholic cardiomyopathy (biomarker_via_orthology)

NOS1 PPARG

2.61e-0441962DOID:12935 (biomarker_via_orthology)
DiseaseParkinson Disease

CYP2E1 MAP3K5 ABCB1 KCNJ4 NOS1

2.62e-04851965C0030567
DiseaseColorectal Carcinoma

ABCA3 HK3 AMACR RPS6KB1 WNK1 ABCB1 BUB1B ZNF624 EVC2 CAD RBP3 PPARG CD9 ACSL5

2.71e-0470219614C0009402
DiseaseUnipolar Depression

CYP2C9 NDUFV1 ABCB1 NOS1 SLC6A15 CLOCK SLC6A13 SLIT3

3.58e-042591968C0041696
Diseasenervous system disorder

CYP2C9 ABCB1 SCN8A NOS1

4.29e-04531964C0027765
DiseasePartial Fetal Alcohol Syndrome

RPS6KA1 NOS1

4.33e-0451962C3661483
Diseaseoculocutaneous albinism (implicated_via_orthology)

OCA2 SLC45A2

4.33e-0451962DOID:0050632 (implicated_via_orthology)
Diseaseporphyria (implicated_via_orthology)

ACO1 IREB2

4.33e-0451962DOID:13268 (implicated_via_orthology)
Diseasearecaidine measurement

SLIT1 SLIT3

4.33e-0451962EFO_0801112
DiseaseMandibulofacial dysostosis

POLR1B POLR1C

4.33e-0451962cv:CN004722
DiseaseAlcohol Related Neurodevelopmental Disorder

RPS6KA1 NOS1

4.33e-0451962C0814154
DiseaseAdenocarcinoma of lung (disorder)

INSRR WNK1 KCNJ4 MYO18B ARHGAP35 SLC4A4 ENO1

4.75e-042061967C0152013
Diseasetobacco smoke exposure measurement

RRN3P2 CHRNB3 CPNE7

5.27e-04241963EFO_0009115
Diseaseautism spectrum disorder (implicated_via_orthology)

CNTNAP3B ABCA3 CNTNAP3 ARID1B LRFN2 NBEA

5.53e-041521966DOID:0060041 (implicated_via_orthology)
Diseasecomplement component 1 q subcomponent-binding protein, mitochondrial measurement

BCHE GPLD1

6.47e-0461962EFO_0020280
DiseaseTreacher Collins syndrome (implicated_via_orthology)

POLR1B POLR1C

6.47e-0461962DOID:2908 (implicated_via_orthology)
DiseaseAlcohol Related Birth Defect

RPS6KA1 NOS1

6.47e-0461962C3146244
DiseaseHallux valgus

LRFN2 PLCL1 SLIT1 SLIT3

6.88e-04601964HP_0001822
Diseaseretinal vasculature measurement

DNER MCM6 EBF2 PLCL1 DNAH5 LAMA2 OCA2 CPS1 TGFBR3 SNTG2 SLC45A2

7.26e-0451719611EFO_0010554
Diseaseserum IgG glycosylation measurement

ACO1 DNER IREB2 PTGR3 SBF1 ARHGAP29 TRAM1L1 RANBP3L SLIT1 SLIT3 EPAS1

7.98e-0452319611EFO_0005193
Diseaseglucose metabolism disease (implicated_via_orthology)

HK3 RPS6KB1 INSRR

8.37e-04281963DOID:4194 (implicated_via_orthology)
Diseasehypertension (biomarker_via_orthology)

ARID1B NOS1 PPARG CPS1 CLOCK SLC4A4 ENO1

8.43e-042271967DOID:10763 (biomarker_via_orthology)
DiseaseIntellectual Disability

SCN8A ASCC3 CACNA1B SLC31A1 NBEA PDHX SLC6A8 AASS ZNF335 PUM1

8.64e-0444719610C3714756
DiseaseMalignant neoplasm of breast

ADAMTS19 ABCA3 HK3 BCHE ITGA9 WNK1 ABCB1 ARID1B SYNJ2 ARHGAP29 ANK1 TCP1 LAMA2 OCA2 ITSN2 SLC6A5 ENO1

8.71e-04107419617C0006142
Diseaselevel of oxylipin in blood plasma

ITGA9 GRIK5

9.02e-0471962OBA_2050338
DiseaseAlbinism, Oculocutaneous

OCA2 SLC45A2

9.02e-0471962C0078918
DiseaseOculocutaneous albinism

OCA2 SLC45A2

9.02e-0471962cv:C0078918
Diseasehistone-lysine n-methyltransferase EHMT2 measurement

CETP BCHE

9.02e-0471962EFO_0020455
Diseaselipoprotein A measurement

CETP ARID1B SYNJ2 TCP1 CPS1

9.28e-041121965EFO_0006925
Diseasehair morphology

S100A11 SLC23A2 FRAS1

9.29e-04291963EFO_0005038
Diseasepolychlorinated biphenyls measurement

INSRR PYGL TGFBR3 TRAM1L1

9.31e-04651964EFO_0007042
Diseasetemporal lobe epilepsy (biomarker_via_orthology)

ABCB1 NOS1 GRIK5

1.13e-03311963DOID:3328 (biomarker_via_orthology)
DiseaseMuscular Dystrophy

BCHE LAMA2

1.20e-0381962C0026850
Diseasemetastatic colorectal cancer, survival time

ANO9 MSGN1

1.20e-0381962EFO_0000714, EFO_1001480
Diseasebipolar II disorder

SLIT1 SLIT3

1.20e-0381962EFO_0009964
Diseasetotal cholesterol measurement, response to escitalopram, response to citalopram

SLIT1 SLIT3

1.20e-0381962EFO_0004574, EFO_0006329, EFO_0007871
Diseasefree cholesterol change measurement, high density lipoprotein cholesterol measurement

SLIT1 SLIT3

1.20e-0381962EFO_0004612, EFO_0020905
DiseaseHereditary spherocytosis

CAD ANK1

1.20e-0381962C0037889
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

1.20e-0381962DOID:0060308 (implicated_via_orthology)
Diseasediastolic blood pressure, self reported educational attainment

SLIT1 SLIT3

1.20e-0381962EFO_0004784, EFO_0006336
DiseaseMajor Depressive Disorder

CYP2C9 NDUFV1 ABCB1 SLC6A15 CLOCK SLC6A13 SLIT3

1.25e-032431967C1269683
Diseaseurinary metabolite measurement

RPS6KB1 UGT3A1 IREB2 PAOX CPS1 PKHD1L1 SLC6A13

1.31e-032451967EFO_0005116
Diseasefatty liver disease (biomarker_via_orthology)

CYP2E1 PPARG CPS1

1.36e-03331963DOID:9452 (biomarker_via_orthology)
Diseasecognitive function measurement

IREB2 KLHL32 ME3 ARID1B LRFN2 KCNJ4 PLCL1 MYO18B DNAH5 PPFIA2 ZNF322 NBEA PPARG PKD1L3 ZNF335 ITSN2 OR2Y1 TNKS ACSL5 CPNE7

1.46e-03143419620EFO_0008354
DiseaseNeoplasm Invasiveness

CYP2E1 ACO1 IREB2 S100A11 TLN1 ENO1

1.49e-031841966C0027626
Disease1-ribosyl-imidazoleacetate measurement

CPS1 SLC6A13

1.53e-0391962EFO_0800034
Diseaseepilepsy (is_implicated_in)

BCHE ABCB1

1.53e-0391962DOID:1826 (is_implicated_in)
Diseasealcohol dependence (implicated_via_orthology)

RPS6KB1 INSRR

1.53e-0391962DOID:0050741 (implicated_via_orthology)
Diseaseobsolete_red blood cell distribution width

MCM6 WNK1 CHRNB3 ME3 ABCB1 COG5 SLC23A2 SEC23B CUL4A CPSF4L CARMIL2 ANK1 ENC1 PPARG CPS1 GBA2 NLRP3 TFR2 SLC15A5

1.68e-03134719619EFO_0005192
Diseasenon-alcoholic fatty liver disease (implicated_via_orthology)

ACO1 NLRP3 SIRT2

1.75e-03361963DOID:0080208 (implicated_via_orthology)
Diseasesleep latency

FRAS1 RANBP3L EPAS1

1.90e-03371963EFO_0005280
Disease1,7-dimethylurate measurement

ITGA2 GRIK5

1.91e-03101962EFO_0021512
Diseaseleptin measurement, sex interaction measurement

SLIT1 SLIT3

1.91e-03101962EFO_0005000, EFO_0008343
Diseaselevel of phosphatidylcholine

CETP SV2B

1.91e-03101962OBA_2040179
Diseasehair colour measurement, eye colour measurement, skin pigmentation measurement

OCA2 SLC45A2

1.91e-03101962EFO_0007009, EFO_0007822, EFO_0009764
DiseaseLiver Cirrhosis, Experimental

DRAM1 AMACR ABCB1 S100A11 TMEM65 VASP ENC1 NBEA CPS1 SLC7A1 ASNS SLC4A4 CTSE

2.11e-0377419613C0023893
Diseasecocaine use

CHRNB3 CLOCK

2.32e-03111962C3496069
Diseasesleep disorder (implicated_via_orthology)

INSRR CLOCK

2.32e-03111962DOID:535 (implicated_via_orthology)
Diseasepigmentation disease (is_implicated_in)

OCA2 SLC45A2

2.32e-03111962DOID:10123 (is_implicated_in)
Diseaseguanosine diphosphate measurement

NBEA NINL

2.32e-03111962EFO_0010494
DiseaseAdverse reaction to drug

CYP2C9 CYP2E1 BCHE ABCB1

2.41e-03841964C0041755
DiseaseDrug toxicity

CYP2C9 CYP2E1 BCHE ABCB1

2.41e-03841964C0013221
Diseaseasparagine measurement

FRAS1 ASRGL1 ASNS

2.56e-03411963EFO_0009766
Diseaserenal cell carcinoma

MYO7B POT1 EPAS1

2.74e-03421963EFO_0000681
Diseaseoral microbiome measurement

FRAS1 APLP2 GRIK5

2.74e-03421963EFO_0801229
DiseaseCooley's anemia

CAD TFR2

2.77e-03121962C0002875
DiseaseThalassemia Minor

CAD TFR2

2.77e-03121962C0085578
Diseaseintegral membrane protein 2B measurement

CETP BCHE

2.77e-03121962EFO_0802634
DiseaseMental Disorders, Severe

ABCB1 NOS1

2.77e-03121962C4046029
Diseasebeta Thalassemia

CAD TFR2

2.77e-03121962C0005283
DiseaseDiagnosis, Psychiatric

ABCB1 NOS1

2.77e-03121962C0376338
DiseaseParkinson Disease, Secondary Vascular

BCHE ABCB1

2.77e-03121962C0751414
DiseaseAtherosclerotic Parkinsonism

BCHE ABCB1

2.77e-03121962C0751415
DiseaseThalassemia Intermedia

CAD TFR2

2.77e-03121962C0271979
DiseaseSecondary Parkinson Disease

BCHE ABCB1

2.77e-03121962C0030569
DiseaseBehavior Disorders

ABCB1 NOS1

2.77e-03121962C0004930
DiseaseMental disorders

ABCB1 NOS1

2.77e-03121962C0004936
Diseaseobesity (biomarker_via_orthology)

CYP2E1 RPS6KB1 NOS1 PPARG CPS1

3.07e-031471965DOID:9970 (biomarker_via_orthology)
Diseasehigh grade glioma (implicated_via_orthology)

INSRR ABCB1 SIRT2

3.13e-03441963DOID:3070 (implicated_via_orthology)
Diseasenevus count, cutaneous melanoma

ANO9 ADGRV1 POT1 SLC45A2

3.22e-03911964EFO_0000389, EFO_0004632
DiseaseRAC-beta serine/threonine-protein kinase measurement

BCHE GPLD1

3.26e-03131962EFO_0021989
DiseaseFetal Alcohol Spectrum Disorders

RPS6KA1 NOS1

3.26e-03131962C2985290

Protein segments in the cluster

PeptideGeneStartEntry
VLLDAGFAVGEQSMV

TDRD1

666

Q9BXT4
VNSMDLGEFVDVFGN

URAD

6

A6NGE7
VLGELAAEMNGVFDT

BUB1B

1011

O60566
QDFTGVPAVVDFAAM

ACO1

86

P21399
MLDGVFAFVLLDTAN

ASNS

116

P08243
EGFIAVVTQDGDMIF

EPAS1

96

Q99814
VLFENADGRFEGSLM

CHRNB3

116

Q05901
VNFGPTVDGDFLTDM

BCHE

316

P06276
ITRDGFLLLQMDFGF

CETP

466

P11597
SSGVFMENLGITDFI

CNTNAP3

826

Q9BZ76
SIIIVGVGNADFAAM

CPNE2

466

Q96FN4
MQEVIAGLERFTFAF

CPSF4L

1

A6NMK7
FLTDQGAAQFAAAMG

ASRGL1

116

Q7L266
ADGEFMAVGAIEPQF

AMACR

226

Q9UHK6
DLADNGFGSDMVTLV

CARMIL2

526

Q6F5E8
EVLEGMSLFAELSGN

ANK1

1286

P16157
DLFVMGGALVLESAA

ABHD18

166

Q0P651
IDLVAYGDINGFSAM

AASS

856

Q9UDR5
DDTGFAAFAMVIITG

ADGRV1

5346

Q8WXG9
VGEEFQIVLSGRGFM

ANTXR2

231

P58335
MADFGISAGQFVAVV

CIAPIN1

1

Q6FI81
TGGAMVIIIGDNFFD

EBF2

266

Q9HAK2
DNFFDGLQVVFGTML

EBF2

276

Q9HAK2
VNVDDDFCFGQVLGM

ABCA3

441

Q99758
AQGFMLLRQAATEFG

PGD

336

P52209
IGNLISFLEDGVTMA

ARID1B

2226

Q8NFD5
LFDNDGTVVFAIFMA

ANO9

261

A1A5B4
IGMQVFGNIALDDDT

CACNA1B

1616

Q00975
GDALMVLEFLNAFGE

BAZ1A

426

Q9NRL2
AGASLDESLFVIEMG

AOX1

876

Q06278
QELRKMGLDFAGFTA

OCA2

496

Q04671
IVGVMFFERAFDQGA

UQCR10

26

Q9UDW1
MDGASAFGTIAIQLA

CRYZL1

151

O95825
MDGITVTVADLFFAG

CYP2E1

286

P05181
GGLMGFIQLNEDFIF

ADAMTS19

241

Q8TE59
QLFVLAGAAEEGFMT

GNAI1

106

P63096
ESGFLTEGEMALIFV

ITSN2

1241

Q9NZM3
LLQDFTGIPAMVDFA

IREB2

86

P48200
AGSEVALAGVFMAVA

SLC16A8

416

O95907
MHVNGFLGAFLFSVE

KCNJ4

116

P48050
VFGEMTDIFANAGNL

ABCB1

71

P08183
GASGLVEVDYNMLAF

MSGN1

86

A6NI15
AGTGFAVAEPQIAMF

APLP2

41

Q06481
LVGCFGMGIVANFQE

DRAM1

101

Q8N682
LLGGADIFSLSVMAF

OR4D11

106

Q8NGI4
EFVIEAGALMLADNG

MCM6

441

Q14566
NELAIFFEGGFLMLG

OR1B1

201

Q8NGR6
QMFVALGGAECFLLA

OR10AC1

106

Q8NH08
GMVVDEFQFSLTDGL

FRAS1

2046

Q86XX4
NFMGLIVALDDNGTA

MGAM2

1686

Q2M2H8
LLDFVDGMQFCSSGF

CTSE

341

P14091
FILAAALGQMNFTGD

CPA5

26

Q8WXQ8
TFLSRLNEFLAGEGM

MOAP1

101

Q96BY2
EQIDMLFFGGSAVSG

PCNX2

981

A6NKB5
IFITVGEDEFQGGMV

FAT2

3536

Q9NYQ8
MGSFNTSFEDGFILV

OR2Y1

1

Q8NGV0
FQGIESGVLLAMALD

OR52A4P

111

A6NMU1
SISNLGMFGIDEFTA

PDHX

416

O00330
FADMQGFTFKGVEIL

MUC3A

3061

Q02505
MISELDFQDSVFVLG

COMMD2

76

Q86X83
DGNGEFIVRMALFQD

GP2

346

P55259
MEAQEGGFAQSLVAL

EVC2

956

Q86UK5
SGGELFMQLEREGIF

RPS6KB1

176

P23443
LDVDANAMLFVGGLT

LAMA2

2271

P24043
GTMFEAIDSVIFATG

FMO6P

316

O60774
MVTEFIFLGLSDSQG

OR4F17

1

Q8NGA8
GDVVTIGGFTFVMND

CRLF2

351

Q9HC73
NEASGLYQMFGVLAD

FOXRED2

441

Q8IWF2
VMLGAGQQLFDFAAH

HK3

131

P52790
FDGILADAGQTVENM

HUWE1

61

Q7Z6Z7
LSDINMDGFNDVIVG

ITGA2

561

P17301
NFDLVEDGLTAMVSG

DMPK

366

Q09013
IVGTLLGFDDFVNMV

LSM5

36

Q9Y4Y9
GNFLVMEELQSGSFV

PCDHB12

31

Q9Y5F1
MEVLGSGAFSEVFLV

CAMK1G

26

Q96NX5
LEGMAFAGFVSERGV

SBF1

421

O95248
AVSNMLLEIGGLEFS

NOS1

571

P29475
DFQALALEGRAMGEQ

PUM1

131

Q14671
NGLFVAFSVAGFDMI

OR52R1

201

Q8NGF1
LLGGADVFSLSVMAF

OR4D9

106

Q8NGE8
AGIAGFFTEELVVMG

ITGA9

196

Q13797
FTFGNILTNFLMGDV

ARHGAP29

141

Q52LW3
LAADFAQMELAVGPF

COG5

701

Q9UP83
VIGMDVAASEFFRSG

ENO1

241

P06733
GEVMAIGRTFEESFQ

CPS1

796

P31327
AVQESQCMLGLFFGF

CD9

81

P21926
FELNVQAFAGGAMGA

GBA2

786

Q9HCG7
VLAAGSAVFDAMFNG

BTBD1

96

Q9H0C5
TLVLLMFNEGDGFSF

CUL4A

596

Q13619
GVGNADFTDMQVLDG

CPNE7

546

Q9UBL6
VGFFQGDIRLLADDM

ACSL5

326

Q9ULC5
SAPAFIMAGEQVFQD

ANGPT4

276

Q9Y264
GDGLNAIVVFAVCFM

BNIP2

161

Q12982
FAGTAILLMDFGVTN

MS4A15

151

Q8N5U1
QMTLGLRFLEDTFGN

MAN2B1

171

O00754
VFVFQGAGEAAMGIA

ME3

331

Q16798
GAFQQFRMEGVSEDL

HUS1B

61

Q8NHY5
QILLMFTATGEDFRG

INSRR

56

P14616
GQTLIRMDFFFTEGA

C2orf50

136

Q96LR7
GNQIFIMGGDTEFSA

ENC1

491

O14682
VGEALAGMELFLFLT

CYP2C9

436

P11712
DNFFDGLQVVFGTML

EBF3

286

Q9H4W6
GIVEDSSNILGFSMF

GRIK5

256

Q16478
LVINTAGEMAGAFVA

SLC31A1

61

O15431
AGEMAGAFVAVFLLA

SLC31A1

66

O15431
EEMLALGNNHFIGFV

DNER

271

Q8NFT8
MAGDILVFLTGQFEI

DHX40

271

Q8IX18
MAQFVQVLAEIGDFG

SLC22A13

1

Q9Y226
QFMSDGADVGFGIFL

SEC14L2

306

O76054
NLFAALSVMIAGFFE

SLC15A5

391

A6NIM6
MIGVVLFDFAADFID

SLC45A2

146

Q9UMX9
DFMLLAVGIIAASAF

CNTD1

251

Q8N815
SSGVFMENLGITDFI

CNTNAP3B

826

Q96NU0
QEVSFNMLDAADGGL

DNAH5

146

Q8TE73
AGIKLIFFFDGMVEQ

FAM120B

81

Q96EK7
GFMETEAAAQESLGL

PPFIA2

851

O75334
FLDSRGVAMVLAVGF

LINGO4

526

Q6UY18
MFILTGFTDDFELQV

OR5T3

41

Q8NGG3
VQLLGDVMSEDGFFY

IL4I1

226

Q96RQ9
GFIAGLESEFMETLS

PAOX

381

Q6QHF9
MAQLFIEHLFGGSEV

OR4A4P

96

Q8NGN8
FMEGVIVLANSGLFS

OR4B1

191

Q8NGF8
LGSFSENGFIKIFME

MAP3K5

741

Q99683
RILFLMDGFDELQGA

NLRP3

296

Q96P20
GAAFQEDDVIMLNGT

RTF2

161

Q9BY42
VQGTGLAFIAFTEAM

SLC6A15

436

Q9H2J7
RDLTINSMFLGFDGT

TRNT1

151

Q96Q11
GFAIFSILGFMAQEQ

SLC6A6

341

P31641
SILGFMAQEQGVDIA

SLC6A6

346

P31641
LFFVLGLALMADGVE

SV2B

111

Q7L1I2
GLALMADGVEVFVVS

SV2B

116

Q7L1I2
FAVGFEEMVELSAGN

SYNJ2

581

O15056
ESFIRGFMTAAGLQI

SLC26A9

201

Q7LBE3
AGFVIFSVIGFMANE

SLC6A5

516

Q9Y345
GVGGQEAMLFTSEIF

MTRF1L

136

Q9UGC7
LMDFDALVQAQTGLG

NDUFV1

336

P49821
MLSFLAATGDDGQAV

NBEAL2

1116

Q6ZNJ1
LNLLVGGEFDLEMNF

NBEA

96

Q8NFP9
GVLISEGQGFMTREF

PPARG

366

P37231
LVAFDGMFAQVETAF

SMG1

2961

Q96Q15
GMFAQVETAFSLLVE

SMG1

2966

Q96Q15
VFVMTFTLDDGTGVL

POT1

541

Q9NUX5
LEMSLVEFGNIGEAF

PKD1L3

386

Q7Z443
LMAAGSFDDILAITG

SLC9B2

271

Q86UD5
AAGGEADMDFLRNLF

SIRT2

31

Q8IXJ6
IFGTMEDFENLVAAI

SLC3A1

186

Q07837
IGINGDFFANMVVDA

TCP1

161

P17987
TFILRGGAEQFMEET

CCT7

371

Q99832
MEAGNQTGFLEFILL

OR7D2

1

Q96RA2
DFSEFLNLIGGLAMA

S100A11

76

P31949
GFVVFSILGFMAAEQ

SLC6A8

356

P48029
DQAADQTGMLFVGDA

SNTG2

106

Q9NY99
LEFDMVGIDAAIANA

POLR1C

61

O15160
NVSFAFELMQDGGLE

PARVA

326

Q9NVD7
DDGSGFAFPDQVLAM

NINL

316

Q9Y2I6
LEGNDGLSFIMSNFE

ARHGAP35

1016

Q9NRY4
AVGTTEFALLGAMAV

OR9A4

106

Q8NGU2
VDAVFVGTGDLFAAM

PDXK

226

O00764
AALEFEDGMYANLGI

OXCT2

306

Q9BYC2
FNGDFRMAFGATLDV

SEC23B

396

Q15437
DAVFELISMGFNVAL

BROX

106

Q5VW32
LTFMVGGVEDEFAAA

HIBADH

171

P31937
VGFFQGDIRLLSDDM

ACSL6

341

Q9UKU0
GREAIESGAAFLFMT

ASCC3

86

Q8N3C0
GSFVDLGILDVMQIF

ASCC3

836

Q8N3C0
EALDGFFLAIMTDGS

CLOCK

116

O15516
FMVDFGNSEVLIVTG

RNF17

516

Q9BXT8
AFDGAASVQELMLTG

SLIT3

576

O75094
FGAFFSGIQLAIMEH

SLC35F1

256

Q5T1Q4
RGAFMQLITVAEGFS

URGCP

726

Q8TCY9
FVAQEGGDIVTFDMC

VWDE

481

Q8N2E2
TVFEAADVDGNGIML

PLCL1

246

Q15111
MSFFGFGQSVEVEIL

VPS26B

1

Q4G0F5
GEIMAAVFFSVGRLS

ZNF624

16

Q9P2J8
GDAGFVLVAFGSMLN

UGT3A1

291

Q6NUS8
GMFFLLGLVFEGTAE

TRAM1L1

31

Q8N609
QGAMTALSFGEVDFT

TNFAIP8L2

96

Q6P589
RFDMFGDGELLTQVS

RBP3

1046

P10745
TAMFVGGCVAFILDN

SLC23A2

556

Q9UGH3
DLEFLAKMTNGFSGA

VCP

671

P55072
ASGAVAAVMAFLFDL

SLC7A1

391

P30825
QDFSTFLEAGVEMAG

TLN1

1276

Q9Y490
NFVFGENMVERVLGT

RANBP3L

211

Q86VV4
AIGFGLARMENQAFD

TRAM2

266

Q15035
EGEVAGLDMNISQFL

TNKS

1021

O95271
AIFSILGFMSQEQGV

SLC6A13

331

Q9NSD5
GLEQGFLRTMGAIDF

GPLD1

136

P80108
CESGFLLGMDFVAQQ

ZNF322

326

Q6U7Q0
FKFTIGMGELAFQEQ

TRPV2

601

Q9Y5S1
MAQGLVTFADVAIDF

ZNF331

1

Q9NQX6
AVGNLVFTGIFTAEM

SCN8A

786

Q9UQD0
GSNFGFEILEISVMI

PKHD1L1

1936

Q86WI1
TEGLCNMGFAEAFLE

RRN3P2

256

A6NIE6
MGIGRSFEEAFQKAL

CAD

766

P27708
MGCLVLAEVGFFSQE

VILL

621

O15195
EGESNFLVFSQMLAG

MYO18B

751

Q8IUG5
ESVGGAMFDLAVDAL

PTGR3

246

Q8N4Q0
IGFGFLDNAIMIVAG

TMEM65

126

Q6PI78
AEVFGEGNMFAVSPV

USP24

256

Q9UPU5
LGDATDNMQGVLESF

SLC4A4

491

Q9Y6R1
DVMLENFALVATLGF

ZNF304

41

Q9HCX3
AVGMSNDGRFLKFDI

WNK1

211

Q9H4A3
FMNVAIFEDEVFAGV

POLR1B

641

Q9H9Y6
LVAFDQMVNLSIDGG

SLIT1

1251

O75093
AVADAAMAQAQGLFG

ZNF335

1301

Q9H4Z2
AEEAGEENLFIFGMR

PYGL

701

P06737
QAMFLQFLGEGRLED

TFR2

141

Q9UP52
GLDTLTVMGIAFAAF

TGFBR3

781

Q03167
QFAAGMASALEALEG

VASP

101

P50552
VAVMGDFLFVAGGEV

KLHL32

341

Q96NJ5
FRGFSFVATGLMEDD

RPS6KA1

376

Q15418
GGLLAFGMAFAVVDA

LRFN2

6

Q9ULH4
AIEAMAAVFGGTQSL

MMUT

371

P22033
LHLGNVGFMASVFEN

MYO7B

326

Q6PIF6