Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninterleukin-10 receptor activity

IL10RA IL10RB

1.35e-052742GO:0004920
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 KCNH4 CHRNG

2.78e-04343747GO:0005261
GeneOntologyBiologicalProcessactin-mediated cell contraction

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 TNNT2

5.42e-06127726GO:0070252
GeneOntologyBiologicalProcessstriated muscle contraction

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 TNNT2 CHRNG

1.07e-05217727GO:0006941
GeneOntologyBiologicalProcessactin filament-based movement

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 TNNT2

1.58e-05153726GO:0030048
GeneOntologyBiologicalProcesscardiac muscle cell contraction

CACNA2D1 KCND3 SCN2A SCN3A ABCC9

1.84e-0593725GO:0086003
GeneOntologyBiologicalProcesscardiac muscle contraction

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 TNNT2

2.59e-05167726GO:0060048
GeneOntologyBiologicalProcesscardiac muscle cell action potential involved in contraction

CACNA2D1 KCND3 SCN2A SCN3A

6.53e-0562724GO:0086002
GeneOntologyBiologicalProcessmuscle contraction

CACNA2D1 MYH13 KCND3 SCN2A SCN3A ABCC9 TNNT2 CHRNG

7.56e-05400728GO:0006936
GeneOntologyBiologicalProcessheart contraction

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 TNNT2 EPAS1

8.08e-05298727GO:0060047
GeneOntologyBiologicalProcessheart process

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 TNNT2 EPAS1

1.01e-04309727GO:0003015
GeneOntologyBiologicalProcesscardiac muscle cell action potential

CACNA2D1 KCND3 SCN2A SCN3A

2.44e-0487724GO:0086001
GeneOntologyBiologicalProcessmembrane depolarization during action potential

CACNA2D1 SCN2A SCN3A

2.68e-0436723GO:0086010
GeneOntologyCellularComponentplasma membrane protein complex

IL10RB TGFBR3 CACNA2D1 KCND3 GNG13 SCN2A SCN3A ABCC9 ITGAE CDH8 KCNH4 CHRNG

1.87e-057857412GO:0098797
GeneOntologyCellularComponentcation channel complex

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 KCNH4

1.85e-04235746GO:0034703
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA2D1 KCND3 SCN2A SCN3A ABCC9 KCNH4 CHRNG

3.80e-04378747GO:0034702
GeneOntologyCellularComponentmembrane protein complex

IL10RB TGFBR3 CACNA2D1 VAC14 KCND3 GNG13 SCN2A SCN3A ABCC9 VTI1A ITGAE CDH8 KCNH4 CHRNG

6.90e-0414987414GO:0098796
HumanPhenoAbnormal ST segment

CACNA2D1 KCND3 ABCC9 TNNT2

3.31e-0539254HP:0012249
HumanPhenoAbnormal electrophysiology of sinoatrial node origin

CACNA2D1 KCND3 ABCC9 TNNT2 EPAS1

3.72e-0581255HP:0011702
DomainSCAMP

SCAMP4 SCAMP5

1.50e-045732IPR007273
DomainSCAMP

SCAMP4 SCAMP5

1.50e-045732PF04144
DomainHEAT_REPEAT

VAC14 INTS4 ULK4 PDS5A

1.62e-0470734PS50077
DomainNa_trans_cytopl

SCN2A SCN3A

2.24e-046732PF11933
DomainNa_trans_cytopl

SCN2A SCN3A

2.24e-046732IPR024583
DomainNa_channel_asu

SCN2A SCN3A

6.64e-0410732IPR001696
DomainNa_trans_assoc

SCN2A SCN3A

6.64e-0410732IPR010526
DomainNa_trans_assoc

SCN2A SCN3A

6.64e-0410732PF06512
DomainTissue_fac

IL10RA IL10RB

9.70e-0412732PF01108
DomainTissue_factor

IL10RA IL10RB

9.70e-0412732IPR001187
DomainIon_trans_dom

KCND3 SCN2A SCN3A KCNH4

1.04e-03114734IPR005821
DomainIon_trans

KCND3 SCN2A SCN3A KCNH4

1.04e-03114734PF00520
DomainChannel_four-helix_dom

KCND3 SCN2A SCN3A

1.44e-0357733IPR027359
Domain-

KCND3 SCN2A SCN3A

1.44e-03577331.20.120.350
DomainPROTEIN_KINASE_ST

LATS1 DYRK1B BUB1B ULK4 STK31 ULK2

2.91e-03362736PS00108
DomainPAS_fold_3

EPAS1 KCNH4

3.61e-0323732IPR013655
DomainPAS_3

EPAS1 KCNH4

3.61e-0323732PF08447
DomainPkinase

LATS1 DYRK1B BUB1B ULK4 STK31 ULK2

3.74e-03381736PF00069
DomainIQ

MYH13 SCN2A SCN3A

3.93e-0381733SM00015
DomainPAS-assoc_C

EPAS1 KCNH4

3.93e-0324732IPR000700
DomainPAC

EPAS1 KCNH4

4.61e-0326732IPR001610
DomainPAC

EPAS1 KCNH4

4.61e-0326732SM00086
DomainPAC

EPAS1 KCNH4

4.61e-0326732PS50113
DomainIQ_motif_EF-hand-BS

MYH13 SCN2A SCN3A

5.28e-0390733IPR000048
DomainIQ

MYH13 SCN2A SCN3A

5.78e-0393733PS50096
DomainPAS

EPAS1 KCNH4

6.93e-0332732SM00091
DomainPAS

EPAS1 KCNH4

7.80e-0334732IPR000014
DomainPAS

EPAS1 KCNH4

7.80e-0334732PS50112
DomainPROTEIN_KINASE_ATP

LATS1 DYRK1B BUB1B ULK4 STK31 ULK2

9.07e-03459736PS00107
DomainARM-type_fold

VAC14 NOM1 INTS4 ULK4 PDS5A

1.05e-02339735IPR016024
Domain-

VAC14 INTS4 ULK4 PDS5A

1.12e-022227341.25.10.10
PathwayREACTOME_NEURONAL_SYSTEM

NRXN3 KCND3 PPFIBP2 GNG13 GLUL ABCC9 KCNH4 CHRNG

3.75e-05335548MM14503
PathwayREACTOME_INTERLEUKIN_10_SIGNALING

IL10RA IL10RB

1.43e-045542MM17220
PathwayREACTOME_NEURONAL_SYSTEM

NRXN3 KCND3 PPFIBP2 GNG13 GLUL ABCC9 KCNH4 CHRNG

1.57e-04411548M735
Pubmed

Haplotype association mapping of acute lung injury in mice implicates activin a receptor, type 1.

TGFBR3 ARHGAP15 CCDC148

8.02e-07975321297076
Pubmed

Confirmation of quantitative trait loci for alcohol preference in mice.

SCN2A SCN3A CHRNG

4.30e-06157539726281
Pubmed

Crystal and solution structures of human oncoprotein Musashi-2 N-terminal RNA recognition motif 1.

MSI1 MSI2

4.59e-06275231603583
Pubmed

Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.

SCN2A SCN3A

4.59e-06275220346423
Pubmed

Knockdown of Musashi RNA Binding Proteins Decreases Radioresistance but Enhances Cell Motility and Invasion in Triple-Negative Breast Cancer.

MSI1 MSI2

4.59e-06275232245259
Pubmed

Expression of RNA-binding protein Musashi in hair follicle development and hair cycle progression.

MSI1 MSI2

4.59e-06275216400011
Pubmed

Characteristic CD103 and CD123 expression pattern defines hairy cell leukemia: usefulness of CD123 and CD103 in the diagnosis of mature B-cell lymphoproliferative disorders.

ITGAE IL3RA

4.59e-06275221917686
Pubmed

IL-10R polymorphisms are associated with very-early-onset ulcerative colitis.

IL10RA IL10RB

4.59e-06275222550014
Pubmed

Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.

SCN2A SCN3A

4.59e-06275211245985
Pubmed

A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency.

IL10RA IL10RB

4.59e-06275224089328
Pubmed

The Musashi proteins MSI1 and MSI2 are required for photoreceptor morphogenesis and vision in mice.

MSI1 MSI2

4.59e-06275233168629
Pubmed

Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.

IL10RA IL10RB

4.59e-06275219890111
Pubmed

Msi RNA-binding proteins control reserve intestinal stem cell quiescence.

MSI1 MSI2

4.59e-06275227799368
Pubmed

Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.

SCN2A SCN3A

4.59e-06275223016767
Pubmed

Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.

SCN2A SCN3A

4.59e-06275227153334
Pubmed

The RNA-binding protein Musashi is required intrinsically to maintain stem cell identity.

MSI1 MSI2

4.59e-06275216717192
Pubmed

Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.

IL10RA IL10RB

4.59e-06275221814839
Pubmed

Musashi proteins are post-transcriptional regulators of the epithelial-luminal cell state.

MSI1 MSI2

4.59e-06275225380226
Pubmed

IL-10 receptor expression on lymphocytes and monocytes in children with food allergy.

IL10RA IL10RB

4.59e-06275233595140
Pubmed

Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes.

MSI1 MSI2

4.59e-06275222113197
Pubmed

Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.

MSI1 MSI2

4.59e-06275228143872
Pubmed

Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.

MSI1 MSI2

4.59e-06275235840700
Pubmed

Mutations in Interleukin-10 Receptor and Clinical Phenotypes in Patients with Very Early Onset Inflammatory Bowel Disease: A Chinese VEO-IBD Collaboration Group Survey.

IL10RA IL10RB

4.59e-06275228267044
Pubmed

Very early-onset inflammatory bowel disease (IBD) in infancy is a different disease entity from adult-onset IBD; one form of interleukin-10 receptor mutations.

IL10RA IL10RB

4.59e-06275224785691
Pubmed

Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.

MSI1 MSI2

4.59e-06275237481823
Pubmed

Knockout of RNA Binding Protein MSI2 Impairs Follicle Development in the Mouse Ovary: Characterization of MSI1 and MSI2 during Folliculogenesis.

MSI1 MSI2

4.59e-06275226131972
Pubmed

RNA-binding protein Musashi family: roles for CNS stem cells and a subpopulation of ependymal cells revealed by targeted disruption and antisense ablation.

MSI1 MSI2

4.59e-06275212407178
Pubmed

RNA binding proteins in spermatogenesis: an in depth focus on the Musashi family.

MSI1 MSI2

4.59e-06275225851660
Pubmed

Assessment of MUSASHI 1 and MUSASHI 2 expression in spermatozoa and testicular tissue.

MSI1 MSI2

4.59e-06275234309875
Pubmed

Interplay between the RNA binding-protein Musashi and developmental signaling pathways.

MSI1 MSI2

4.59e-06275231692135
Pubmed

Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis.

IL10RA IL10RB

4.59e-06275224379584
Pubmed

Dual Knockdown of Musashi RNA-Binding Proteins MSI-1 and MSI-2 Attenuates Putative Cancer Stem Cell Characteristics and Therapy Resistance in Ovarian Cancer Cells.

MSI1 MSI2

4.59e-06275234768932
Pubmed

Clinical features of interleukin 10 receptor gene mutations in children with very early-onset inflammatory bowel disease.

IL10RA IL10RB

4.59e-06275225373860
Pubmed

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins.

MSI1 MSI2

4.59e-06275230097032
Pubmed

Voltage-gated sodium channels in taste bud cells.

SCN2A SCN3A

1.37e-05375219284629
Pubmed

Conformational changes mediate interleukin-10 receptor 2 (IL-10R2) binding to IL-10 and assembly of the signaling complex.

IL10RA IL10RB

1.37e-05375216982608
Pubmed

Association Between Interleukin-10 Receptors and the CD45-Immunophenotype of Central Nervous System Tumors: A Preliminary Study.

IL10RA IL10RB

1.37e-05375228982901
Pubmed

Identification and functional characterization of a second chain of the interleukin-10 receptor complex.

IL10RA IL10RB

1.37e-0537529312047
Pubmed

Tau oligomers mediate aggregation of RNA-binding proteins Musashi1 and Musashi2 inducing Lamin alteration.

MSI1 MSI2

1.37e-05375231532069
Pubmed

Association of IL10RA, IL10RB, and IL22RA Polymorphisms/Haplotypes with Susceptibility to and Clinical Manifestations of SLE.

IL10RA IL10RB

1.37e-05375237511050
Pubmed

Sodium channels SCN1A, SCN2A and SCN3A in familial autism.

SCN2A SCN3A

1.37e-05375212610651
Pubmed

Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.

IL10RA IL10RB

1.37e-05375222549091
Pubmed

Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site.

IL10RA IL10RB

1.37e-05375211485736
Pubmed

SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis.

SCN2A SCN3A

1.37e-05375223859570
Pubmed

Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression.

SCN2A SCN3A

1.37e-05375218784617
Pubmed

Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences.

SCN2A SCN3A

1.37e-05375217544618
Pubmed

Evidence for non-neutralizing autoantibodies against IL-10 signalling components in patients with inflammatory bowel disease.

IL10RA IL10RB

1.37e-05375224581234
Pubmed

Overexpression of ZNF217 in glioblastoma contributes to the maintenance of glioma stem cells regulated by hypoxia-inducible factors.

ZNF217 EPAS1

1.37e-05375221483406
Pubmed

IL10 receptor is a novel therapeutic target in DLBCLs.

IL10RA IL10RB

1.37e-05375225733167
Pubmed

Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population.

IL10RA IL10RB

1.37e-05375221532858
Pubmed

Formation of Toxic Oligomeric Assemblies of RNA-binding Protein: Musashi in Alzheimer's disease.

MSI1 MSI2

1.37e-05375230367664
Pubmed

Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells.

SCN2A SCN3A

1.37e-05375216052353
Pubmed

RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction.

MSI1 MSI2

1.37e-05375232855391
Pubmed

The Musashi proteins direct post-transcriptional control of protein expression and alternate exon splicing in vertebrate photoreceptors.

MSI1 MSI2

1.37e-05375236153373
Pubmed

Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.

IL10RA IL10RB

1.37e-05375230998505
Pubmed

Modulation of IL10 and Its Receptor Subunits in Normal and Progesterone-Prolonged Gestation in the Mouse.

IL10RA IL10RB

1.37e-05375232016805
Pubmed

Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor.

IL10RA IL10RB

1.37e-05375228678006
Pubmed

Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex.

SCN2A SCN3A

1.37e-05375214973256
Pubmed

Association between IL10, IL10RA, and IL10RB SNPs and ischemic stroke with hypertension in Korean population.

IL10RA IL10RB

1.37e-05375223096091
Pubmed

Phenotypic characterization of very early-onset IBD due to mutations in the IL10, IL10 receptor alpha or beta gene: a survey of the Genius Working Group.

IL10RA IL10RB

1.37e-05375224216686
Pubmed

Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor.

IL10RA IL10RB

1.37e-05375219409109
Pubmed

Brugada Syndrome

CACNA2D1 KCND3 ABCC9

1.89e-052475320301690
Pubmed

Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation.

SCN2A SCN3A

2.75e-05475217537961
Pubmed

Sodium channel expression and transcript variation in the developing brain of human, Rhesus monkey, and mouse.

SCN2A SCN3A

2.75e-05475235031483
Pubmed

Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma.

SCN2A SCN3A

2.75e-05475229578003
Pubmed

The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs.

MSI1 MSI2

2.75e-05475238467682
Pubmed

Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function.

IL10RA IL10RB

2.75e-05475224792912
Pubmed

Association of sodium voltage-gated channel genes polymorphisms with epilepsy risk and prognosis in the Saudi population.

SCN2A SCN3A

2.75e-05475235801810
Pubmed

RNA binding protein Musashi-1 directly targets Msi2 and Erh during early testis germ cell development and interacts with IPO5 upon translocation to the nucleus.

MSI1 MSI2

2.75e-05475225782991
Pubmed

Use of recombinant inbred strains for studying genetic determinants of responses to alcohol.

SCN2A SCN3A

2.75e-0547528974318
Pubmed

Novel SCAMPs lacking NPF repeats: ubiquitous and synaptic vesicle-specific forms implicate SCAMPs in multiple membrane-trafficking functions.

SCAMP4 SCAMP5

4.57e-05575211050114
Pubmed

Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2.

SCN2A SCN3A

4.57e-0557521679748
Pubmed

A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2.

SCN2A SCN3A

4.57e-0557528812438
Pubmed

The Msi Family of RNA-Binding Proteins Function Redundantly as Intestinal Oncoproteins.

MSI1 MSI2

4.57e-05575226673327
Pubmed

Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle.

MSI1 MSI2

4.57e-05575237477898
Pubmed

A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice.

IL10RA IL10RB

4.57e-05575222753938
Pubmed

Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels.

SCN2A SCN3A

4.57e-05575217724025
Pubmed

Structure and mechanism of receptor sharing by the IL-10R2 common chain.

IL10RA IL10RB

4.57e-05575220462497
Pubmed

Image-based detection and targeting of therapy resistance in pancreatic adenocarcinoma.

MSI1 MSI2

4.57e-05575227281208
Pubmed

Transformation of the intestinal epithelium by the MSI2 RNA-binding protein.

MSI1 MSI2

4.57e-05575225774828
Pubmed

Developmental expression of Musashi-1 and Musashi-2 RNA-binding proteins during spermatogenesis: analysis of the deleterious effects of dysregulated expression.

MSI1 MSI2

4.57e-05575224671879
Pubmed

Comparison of interleukin-22 and interleukin-10 soluble receptor complexes.

IL10RA IL10RB

4.57e-05575212513909
Pubmed

Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy.

SCN2A SCN3A

4.57e-05575224337656
Pubmed

Re-evaluation of IL-10 signaling reveals novel insights on the contribution of the intracellular domain of the IL-10R2 chain.

IL10RA IL10RB

4.57e-05575229016674
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

NRXN3 KCND3 CHD5

5.02e-053375322357600
Pubmed

Interleukin-10 (IL-10) pathway: genetic variants and outcomes of HIV-1 infection in African American adolescents.

IL10RA IL10RB

6.84e-05675220976276
Pubmed

Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy.

IL10RA IL10RB

6.84e-05675218674658
Pubmed

The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.

MSI1 MSI2

6.84e-05675217768378
Pubmed

Proliferation tracing reveals regional hepatocyte generation in liver homeostasis and repair.

GLUL TNNT2

6.84e-05675233632818
Pubmed

Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity.

IL10RA IL10RB

6.84e-05675234879221
Pubmed

Presynaptic α2δ-2 Calcium Channel Subunits Regulate Postsynaptic GABAA Receptor Abundance and Axonal Wiring.

CACNA2D1 NRXN3

6.84e-05675230683685
Pubmed

A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain.

SCN2A SCN3A

6.84e-05675223652591
Pubmed

Extensive variation between inbred mouse strains due to endogenous L1 retrotransposition.

ARHGAP15 PARP8

9.57e-05775218381897
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

FSIP2 LATS1 NAA15 PARP8 DYRK1B BUB1B PLEKHA2 AKAP11 USP54

9.77e-0586175936931259
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

ISLR2 NRXN3 TSR1 CHD5 AKAP11 DDX55 ACAP3

1.47e-0452975714621295
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN2A SCN3A

1.64e-04975216382098
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN2A SCN3A

1.64e-04975215746173
Pubmed

Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis.

SYCP1 TEX15

2.04e-041075218283110
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA2D1 KCND3 SCN3A ABCC9

2.38e-0413975416985003
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

LATS1 NRXN3 MYH13 PARP8 CHD5 SYCP1 ANKRD30A DDX55 STK31 PRRC2B CCDC148

2.56e-041442751135575683
GeneFamilySecretory carrier membrane proteins

SCAMP4 SCAMP5

7.16e-055492735
GeneFamilyCD molecules|I-set domain containing|Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing

IL10RA IL10RB IL3RA

1.99e-0442493602
GeneFamilySodium voltage-gated channel alpha subunits

SCN2A SCN3A

2.56e-0494921203
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_top-relative-expression-ranked_1000

KLF8 VAC14 VMA21 NAA15 TSR1 SYCP1 AKAP11 DEFB136 ZNF217 TEX15 TRAPPC8 STK31

2.52e-058227412gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_k-means-cluster#1_top-relative-expression-ranked_100

GNG13 SYCP1 TEX15

3.78e-0519743gudmap_developingGonad_e18.5_ovary_100_k1
CoexpressionAtlasdev gonad_e12.5_M_GermCellTestis_Oct_k-means-cluster#4_top-relative-expression-ranked_1000

ASF1B SYCP1 TEX15 STK31

1.17e-0472744gudmap_dev gonad_e12.5_M_GermCellTestis_Oct_k4_1000
CoexpressionAtlasDevelopingGonad_e18.5_ovary_emap-12283_top-relative-expression-ranked_100

GNG13 SYCP1 TEX15 STK31

1.17e-0472744gudmap_developingGonad_e18.5_ovary_100
CoexpressionAtlasDevelopingKidney_e15.5_Podocyte cells_emap-27915_top-relative-expression-ranked_1000

PALD1 CACNA2D1 VMA21 NRXN3 ARHGAP15 KCND3 PLEKHA2 TNNT2 MARCO EPAS1 TULP3

1.43e-048367411gudmap_developingKidney_e15.5_Podocyte cells_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_adult_bladder_emap-29457_k-means-cluster#1_top-relative-expression-ranked_1000

CACNA2D1 KCND3 SCN2A ABCC9 TNNT2

1.68e-04148745gudmap_developingLowerUrinaryTract_adult_bladder_1000_k1
CoexpressionAtlasDevelopingGonad_e14.5_ ovary_emap-6699_k-means-cluster#3_top-relative-expression-ranked_200

GNG13 SYCP1 TEX15

1.70e-0431743gudmap_developingGonad_e14.5_ ovary_200_k3
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_k-means-cluster#1_top-relative-expression-ranked_1000

TGFBR3 CACNA2D1 KCND3 ABCC9 PCMTD1

1.74e-04149745gudmap_developingLowerUrinaryTract_P1_bladder_J_1000_k1
CoexpressionAtlase9.5_MaxilArch_top-relative-expression-ranked_500_3

AKAP11 PRRC2B

1.78e-046742Facebase_ST1_e9.5_MaxilArch_500_3
CoexpressionAtlasdev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#2_top-relative-expression-ranked_200

SYCP1 TEX15 STK31

2.45e-0435743gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k2_200
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NRXN3 KCND3 CHD5 SCN2A SCN3A CDH8

7.79e-07188756b73e8a40393c3f656e2fcfe395a761b1f985c254
ToppCellIPF-Epithelial-PNEC|IPF / Disease state, Lineage and Cell class

CACNA2D1 KCND3 SCN2A SCN3A SLC6A5

7.32e-06159755adec82df944fe8699a69ca52534353bef100f2f9
ToppCellIPF-Epithelial-PNEC|World / Disease state, Lineage and Cell class

CACNA2D1 KCND3 SCN2A SCN3A SLC6A5

7.77e-06161755133833729ba8b6d3eef326590ca7476b17602cbb
ToppCell3'_v3-blood-Mast-Mast_cells|blood / Manually curated celltypes from each tissue

NAA15 GLUL IL3RA EPAS1 MSI2

1.20e-05176755b9da3deaf62622d47eb30b6be7548253eee95597
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA2D1 KCND3 SCN2A SCN3A SLC6A5

1.73e-0519075540d8b3403f4e38436b961cd3a2e69826cbae3042
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell-Neuroendocrine-Neuroendocrine_L.0.7.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA2D1 KCND3 SCN2A SCN3A SLC6A5

1.73e-05190755f6cbf6d292f488ada5f7581e1dceba6198b933d1
ToppCell3'-Broncho-tracheal-Epithelial-Neuro-endocrine/ionocytic-lung_neuroendocrine_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CACNA2D1 KCND3 SCN2A SCN3A SLC6A5

1.73e-05190755a9a705455019e28d655636de73b07540798f82e6
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 NRXN3 CHD5 SCN2A KCNH4

1.87e-05193755be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellRV-08._Macrophage|RV / Chamber and Cluster_Paper

IL10RA ARHGAP15 PARP8 BUB1B MARCO

1.87e-0519375512bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 NRXN3 CHD5 SCN2A KCNH4

1.87e-051937550c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 NRXN3 CHD5 SCN2A KCNH4

1.87e-051937558689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

ISLR2 NRXN3 CHD5 SCN2A SCN3A

2.06e-051977554961f66606f08e399508fd6cabca588e7ab406a8
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

IL10RA ARHGAP15 GLUL PLEKHA2 MARCO

2.11e-051987559bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellTracheal-NucSeq-Immune_Myeloid-Monocytic-Monocyte_CD16|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IL10RA PALD1 ARHGAP15 MARCO KCNH4

2.11e-051987550b928a829844f49f4d47e88908af192cb919011f
ToppCellParenchymal-NucSeq-Immune_Lymphocytic-T-T_CD8-gdT|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

IL10RA ARHGAP15 PARP8 PLEKHA2 ITGAE

2.21e-052007551779a8ff4443a85ac500f849764e86d9c7529b84
ToppCellBrain_organoid-organoid_Tanaka_cellReport-10w-Neuronal|10w / Sample Type, Dataset, Time_group, and Cell type.

CACNA2D1 NRXN3 CHD5 SCN2A SCN3A

2.21e-05200755979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCell343B-Myeloid-Dendritic-cDC1|343B / Donor, Lineage, Cell class and subclass (all cells)

VAC14 SCN3A PLEKHA2 VTI1A

1.14e-04148754e44cdc1c3f3314c549a0afa9298c8568022b9d8b
ToppCell10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8|Lung / Manually curated celltypes from each tissue

ARHGAP15 GAS2L2 PARP8 CCDC148

1.40e-0415675410d191e29b16cae8238e8df6c0ff38882253f34e
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD5 SCN2A IL3RA TULP3

1.43e-04157754ed9c9feefc06c9536c03bedbc3397a2ee492a78e
ToppCellfacs-Marrow-T-cells-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHD5 SCN2A IL3RA TULP3

1.43e-04157754fddcb24776b9f86e000208bae54541b15b2adefd
ToppCellCOPD-Epithelial-PNEC|COPD / Disease state, Lineage and Cell class

CACNA2D1 KCND3 SCN3A SLC6A5

1.50e-041597546018124980c55190928409f3bf41d846a118954a
ToppCellCOPD-Epithelial-PNEC|World / Disease state, Lineage and Cell class

CACNA2D1 KCND3 SCN3A SLC6A5

1.54e-04160754cdea93317b0ebb801ddbe73bca6149ce2c727f16
ToppCellGlobus_pallidus-Neuronal-Excitatory|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

ISLR2 CACNA2D1 TNNT2 KCNH4

1.54e-04160754f843287ed57d2d5a3b3f6dfb03b6934e330e6645
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_ALM_Oprk1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IL10RB ISLR2 PLEKHA2 KCNH4

1.61e-041627542d28306c6125b31f11ea6d911a167b93a74907c5
ToppCellIPF-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

KCND3 SCN2A SCN3A SLC6A5

1.61e-04162754865d0e215d54fb1412f00cf0649c71c2f1878e57
ToppCellmild_COVID-19_(asymptomatic)-pDC|World / disease group, cell group and cell class (v2)

PALD1 KCND3 SCAMP5 IL3RA

1.81e-04167754bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-PMP-PMP_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SCN3A ABCC9 MSI1 MAN1B1

1.90e-041697547cb1b87be66a22fe5731bb1b55bc515920fe3e8b
ToppCellCOVID-19_Severe-CD4+_CTL|World / disease group, cell group and cell class

TGFBR3 ISLR2 NRXN3 PARP8

1.90e-041697548c8168ac93a808d7b4756e4491db2b2979df1c1f
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 SCN3A TNNT2 KCNH4

1.90e-0416975412bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL10RA VMA21 ARHGAP15 MARCO

1.94e-0417075428fb192b21cdc5a77ba4f276694cff852eb2304b
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND3 GNG13 RGS22 TNNT2

1.94e-0417075417bd7fd25a2657cb536ad47e294332920f759e95
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_T/NK-Natural_Killer_Cell_/_Natural_Killer_T_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

IL10RA VMA21 ARHGAP15 MARCO

1.94e-04170754239cb4b801b2d71a6facb386f2684c0851504151
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

IL10RA ARHGAP15 ASF1B BUB1B

2.03e-04172754ef33b5e0515c6d29fb6d9a673011c1b68ef264f3
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND3 PPFIBP2 SCN3A ABCC9

2.07e-04173754d78397e65e997ddb995111a810f0e2a4f67d0765
ToppCellfacs-Heart-LV-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND3 PPFIBP2 SCN3A ABCC9

2.07e-041737543c852ffe22f4a5b632463086b08c669310684e80
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 KCND3 TNNT2 KCNH4

2.07e-0417375466f37c1437705734b20601656fa4aa1d92ca30be
ToppCellfacs-Diaphragm-Limb_Muscle-24m-Mesenchymal-nan|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 KCND3 TNNT2 KCNH4

2.07e-04173754649b08a409095592cccf31883be69c754411280d
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KLF8 ASF1B BUB1B ITGAE

2.21e-04176754581045e61cdcdfa85701343d1a7c0a72a36606a7
ToppCellCOVID-19_Severe-CD4+_CTL|COVID-19_Severe / disease group, cell group and cell class

TGFBR3 ISLR2 NRXN3 PARP8

2.26e-0417775434e9455790bae905dd91923792f4109d18b7686e
ToppCellPND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KCND3 SCN2A TNNT2 STK31

2.26e-041777547ebdcedfe02da6d05bba3d625d8bd4c4ea96e4ad
ToppCellE16.5-Immune-Immune_Myeloid-DC|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA PDE4A ARHGAP15 PARP8

2.26e-04177754235254c08b44c20ee3cb62dd2ca0c7e46a2587e3
ToppCellE16.5-Immune-Immune_Myeloid-DC-cDC2|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA PDE4A ARHGAP15 PARP8

2.26e-04177754b59d9fcf0a4964ef2d6274b6021a69cf7d335e0a
ToppCellE16.5-Immune-Immune_Myeloid-DC-cDC2-cDC2_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA PDE4A ARHGAP15 PARP8

2.26e-04177754f55332fe7fc32c23892ccf08b6b4d5b1ffcc0d3f
ToppCellfacs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA2D1 ULK4 AKAP11 CDH8

2.31e-04178754fcbbcc44271515de1969b4732b6441c012693d5f
ToppCellfacs-Large_Intestine-Proximal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCND3 GNG13 MSI1 TNNT2

2.31e-0417875409a215a0d6e98e4bb920cabda12af08ff4de3c98
ToppCellCOPD-Epithelial-PNEC|Epithelial / Disease state, Lineage and Cell class

CACNA2D1 KCND3 SCN3A SLC6A5

2.36e-04179754988d0853c391da1e5004f73f3678047418d3f6d3
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 GNG13 SCN2A ITGAE

2.41e-041807546ac62bf1251978c8c12e715f7b73144fca619794
ToppCell3'_v3-bone_marrow-Mast|bone_marrow / Manually curated celltypes from each tissue

GLUL TEX15 IL3RA EPAS1

2.41e-04180754b37ee81b792213d6595b4ec65d04bc35d83321c7
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell_cycling|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ASF1B SCN2A SCN3A BUB1B

2.41e-04180754401df9cddcbca1eb8f0d2687bcacd98e95dc1493
ToppCell3'_v3-bone_marrow-Mast-Mast_cells|bone_marrow / Manually curated celltypes from each tissue

GLUL TEX15 IL3RA EPAS1

2.46e-0418175430ec4635474ee0f0ea1415ec0ba7f008d97e8c1a
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CACNA2D1 KCND3 SCN2A SCN3A

2.52e-0418275457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellE18.5-samps-Endothelial-Mature_fetal_endothelial-endothelial_cells_A|E18.5-samps / Age Group, Lineage, Cell class and subclass

ASF1B BUB1B NXPE2 EPAS1

2.52e-04182754ea4f6c8f600ffe9f8e0609637b3371a5ac48ca03
ToppCellT_cells-Resident_memory_CD8+_T_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

PARP8 GLUL ITGAE EPAS1

2.52e-04182754111d434b89902ec11fb07f41b8ee1a98f3991b61
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR3 KCND3 VTI1A TNNT2

2.57e-041837543c516fe5083f02bad1f464ed284010b4131a833c
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR3 KCND3 VTI1A TNNT2

2.57e-041837549c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCellfacs-Aorta-Heart-3m-Myeloid-leukocyte|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA ARHGAP15 ASF1B ITGAE

2.57e-04183754062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCellPCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

ISLR2 CHD5 SCN2A SCN3A

2.62e-04184754571136c832cb8c08457744152231537aa8e8abd7
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_int|lung / Disease (COVID-19 only), tissue and cell type

ARHGAP15 SCN3A BUB1B MSI2

2.62e-04184754480595a0e2e6aa2a77b7daa36490ae3af3d8dfee
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR3 KCND3 VTI1A TNNT2

2.62e-041847547294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN3 SCN3A ABCC9 EPAS1

2.68e-0418575451dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NRXN3 PPFIBP2 PLEKHA2 ABCC9

2.68e-04185754a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR3 KCND3 VTI1A TNNT2

2.68e-041857549197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

TGFBR3 CACNA2D1 KCND3 ABCC9

2.68e-04185754a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR3 KCND3 VTI1A TNNT2

2.68e-04185754ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCellLA-07._Pericyte|LA / Chamber and Cluster_Paper

ARHGAP15 SCN3A ABCC9 EPAS1

2.68e-04185754ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCellnormal-na-Myeloid-plasmacytoid_dendritic_cell-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

PALD1 SCAMP5 IL3RA CDH8

2.68e-041857543091870a5bf8ecb963e560b47c8502bae367416c
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NRXN3 SCN3A ABCC9 EPAS1

2.68e-04185754a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCellCOVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi|lung / Disease (COVID-19 only), tissue and cell type

ARHGAP15 SCN3A BUB1B MSI2

2.73e-0418675466676d9395172de5707e204826a1c9f73b448cca
ToppCellSubstantia_nigra-Neuronal-Inhibitory|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

NRXN3 KCND3 CHD5 CDH8

2.73e-041867549d3efe2a4feea2bc205a7e45b9b9f9ed9b3609ce
ToppCellRV-07._Pericyte|RV / Chamber and Cluster_Paper

ARHGAP15 SCN3A ABCC9 EPAS1

2.73e-04186754c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCellRV-07._Pericyte|World / Chamber and Cluster_Paper

ARHGAP15 SCN3A ABCC9 EPAS1

2.79e-04187754dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_arterial_EC|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ISLR2 GLUL IL3RA EPAS1

2.79e-04187754d9d10ed7c905778a29a0dc3ced3eef02a6b1de5c
ToppCellwk_08-11-Endothelial-Blood_vessel_endothelial-GRIA2+_arterial_endo|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

ISLR2 SYCP1 IL3RA EPAS1

2.79e-04187754a27aa97aa6508a3ffe92c2b6bb0511a95650a390
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A MSI2 CCDC148

2.85e-04188754bc089cd73d283ed7d2ecbb3936673b4edc89f666
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A MSI2 CCDC148

2.85e-04188754eec3d353e51358db4c7621265ee0fdd4298e5b0e
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

PALD1 NRXN3 CDH8 EPAS1

2.85e-0418875402a62888e9db29d20133eeca1686d302545a39c9
ToppCellCOVID-19-kidney-DCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

SCN2A SCN3A MSI2 CCDC148

2.85e-041887541d56cd409793f05cca20757ab26e91f1a1ee67b5
ToppCellbackground-B_cells|background / Sample and Cell Type and Tumor Cluster (all cells)

KLF8 ARHGAP15 PLEKHA2 IL3RA

2.85e-041887549acb7a95e3095f15918a5d094107d1d565a42842
ToppCell5'-Adult-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TGFBR3 NRXN3 KCND3 ABCC9

2.85e-04188754879de94924de978478696fc7838e05a4d795b905
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A MSI2 CCDC148

2.90e-04189754975c0f079903ae36b0ffa54e86294d42ec7697de
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SCN2A SCN3A MSI2 CCDC148

2.90e-041897547eb8f5a951e80f1cfac4d7c9eb169f4eb100c917
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 TGFBR3 CACNA2D1 EPAS1

2.96e-04190754656483751e4bf137e4e4bfb2a03a478a8f7fcb63
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IL10RA TGFBR3 ARHGAP15 PARP8

2.96e-04190754d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCellFetal_29-31_weeks-Immune-B_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP15 SCN3A PLEKHA2 MSI2

2.96e-04190754424550418c1bd4eb070cf3c41cf09fa9d89aef37
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PALD1 TGFBR3 CACNA2D1 EPAS1

3.02e-04191754f663131a4810584c5854bd64ee7991a237b7707f
ToppCellFetal_29-31_weeks-Immune-B_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ARHGAP15 SCN3A PLEKHA2 MSI2

3.02e-0419175484452125d1b5b76974e3f9126f611eff16d45c25
ToppCell15-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

CACNA2D1 KCND3 SCN2A SCN3A

3.02e-0419175476311fa5f3ae9bb27cf04387a8c92300f2888c28
ToppCellRV-08._Macrophage|World / Chamber and Cluster_Paper

IL10RA ARHGAP15 PARP8 BUB1B

3.08e-04192754a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCellNS-moderate-d_07-13-Lymphoid-CTL|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

IL10RA ARHGAP15 PARP8 ITGAE

3.08e-04192754ab2c3d829f5cbf4eb386babcfdf851222a2a88e8
ToppCellEntopeduncular-Neuronal|Entopeduncular / BrainAtlas - Mouse McCarroll V32

NRXN3 CHD5 SCN2A CDH8

3.08e-041927544c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCelldroplet-Bladder-nan-3m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A ABCC9 NXPE2 EPAS1

3.14e-041937548be24713f8ba2545b7647d1994e9e993623ddaa3
ToppCelldroplet-Bladder-nan-3m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A ABCC9 NXPE2 EPAS1

3.14e-0419375419dfc4a2c91fcea4f5991e7c44df46faeecb06b8
ToppCelldroplet-Bladder-nan-3m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCN3A ABCC9 NXPE2 EPAS1

3.14e-04193754351e0acd411a9eb0dbc0e358d0d1e3759753fa40
ToppCellCOVID-19-Heart-Macrophage|Heart / Disease (COVID-19 only), tissue and cell type

IL10RA ARHGAP15 PARP8 MARCO

3.21e-04194754f09675cd472200363c458952f00d2e41990800ee
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

PDE4A GLUL IL3RA EPAS1

3.21e-041947545da8873cddff582e5693b32fd3aaebc102f65fc0
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

IL10RA PDE4A GLUL IL3RA

3.21e-041947543043f6230fa723037c8cf7123f611ae847b39fd4
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

PDE4A CHD5 SCN2A AKAP11

3.21e-041947548aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellLA-08._Macrophage|World / Chamber and Cluster_Paper

IL10RA ARHGAP15 PARP8 MARCO

3.21e-04194754c1805572bcc11b1cd29083329d7b5911489fb758
ToppCellNasal_Brush-Immune|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X

IL10RA PALD1 ARHGAP15 MARCO

3.21e-041947543135bc4a8112c5dee108e3b8e775f508b65191f1
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

TGFBR3 NRXN3 ARHGAP15 ABCC9

3.27e-04195754803f714d91f2d97ecbee8c15a5139fd9310f66c7
DiseaseBrugada Syndrome (disorder)

CACNA2D1 KCND3 ABCC9

2.95e-0524743C1142166
Diseaseautism spectrum disorder (implicated_via_orthology)

NRXN3 NAA15 SCAMP4 SCAMP5 SCN2A

4.11e-05152745DOID:0060041 (implicated_via_orthology)
Diseaselower face morphology measurement

ARHGAP15 KCND3 VTI1A EPAS1

1.66e-04109744EFO_0010948
DiseaseSudden Cardiac Arrest

KCND3 TNNT2

1.72e-048742C1720824
DiseaseProstatic Cancer, Castration-Resistant

ASF1B ZNF217

2.21e-049742C3658266
DiseaseProstatic Neoplasms, Castration-Resistant

ASF1B ZNF217

2.21e-049742C3658267
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN2A SCN3A

2.76e-0410742DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN2A SCN3A

2.76e-0410742DOID:0080422 (implicated_via_orthology)
DiseaseOther specified cardiac arrhythmias

CACNA2D1 KCND3

3.36e-0411742C0348626
DiseaseTachycardia, Ventricular

ABCC9 TNNT2

3.36e-0411742C0042514
DiseaseNodal rhythm disorder

CACNA2D1 KCND3

3.36e-0411742C0264893
DiseaseEctopic rhythm

CACNA2D1 KCND3

3.36e-0411742C1399226
DiseaseCARDIAC CONDUCTION DEFECT, NONSPECIFIC (disorder)

CACNA2D1 KCND3

3.36e-0411742C2748542
DiseaseShortened QT interval

CACNA2D1 ABCC9

3.36e-0411742C0151879
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN2A SCN3A

4.03e-0412742DOID:0060170 (implicated_via_orthology)
DiseaseBrugada Syndrome 1

CACNA2D1 KCND3

4.75e-0413742C4551804
DiseaseSinus Node Dysfunction (disorder)

CACNA2D1 KCND3

6.38e-0415742C0428908
DiseaseP wave duration

KCND3 EPAS1

6.38e-0415742EFO_0005094
Diseasealpha-tocopherol measurement

CACNA2D1 SCN3A

1.14e-0320742EFO_0007898
Diseaseanxiety disorder (implicated_via_orthology)

SCN2A SCN3A

1.39e-0322742DOID:2030 (implicated_via_orthology)
Diseaseresponse to diuretic

PALD1 CDH8

1.52e-0323742GO_0036270
Diseaseamino acid measurement

CACNA2D1 PPIG ARHGAP15 SLC6A5 ULK4 NXPE2 EPAS1

1.56e-03678747EFO_0005134
DiseaseCardiac Arrhythmia

CACNA2D1 KCND3

1.79e-0325742C0003811
DiseaseColorectal Carcinoma

KCND3 PARP8 CHD5 BUB1B VTI1A ZNF217 KCNH4

1.90e-03702747C0009402
Diseaseelectrocardiography

KCND3 GLUL VTI1A DEFB136 TNNT2 EPAS1

2.16e-03530746EFO_0004327

Protein segments in the cluster

PeptideGeneStartEntry
IAPPMPRAKENELQA

BUB1B

296

O60566
MPDKPLSANVPNDKF

EPAS1

751

Q99814
PQKPPRKDMESTVFK

CCDC148

576

Q8NFR7
MDEKDPGAQKPRQPL

CHD5

1576

Q8TDI0
QRRNVPMKPPDEAKV

BRD9

461

Q9H8M2
RPAKMLLDPAAPAQE

CHRNG

211

P07510
KNEQTLRADPMFPPE

ANKRD30A

541

Q9BXX3
LRADPMFPPESKQKD

ANKRD30A

546

Q9BXX3
KFLRKAPMAPALEAP

ACAP3

516

Q96P50
MNPQKFKFDRPALPA

AKAP11

396

Q9UKA4
FMNPQKVKPPEDLQD

ABCC9

196

O60706
IPPAAMLDQAPKARK

DYRK1B

331

Q9Y463
PQAPDPMEKRIAADF

ISLR2

631

Q6UXK2
IDPKVAFPRRAQPKM

MSI2

91

Q96DH6
KLANPKQPTNPFLEM

PDS5A

596

Q29RF7
QAQMIHPKPADFRNP

INTS4

871

Q96HW7
EAAPTQAKPLPMEQF

PALD1

341

Q9ULE6
DPNDPQMLAFNPRKK

PARP8

586

Q8N3A8
PMPLAPADKNKRQDE

KCND3

26

Q9UK17
KMSTEDPRQVRNPPK

LATS1

56

O95835
PKMPELRGKQFPDFV

DDX55

461

Q8NHQ9
LPNAEKMFSFPPIDK

FSIP2

5331

Q5CZC0
KRMQKPPSPNIQCDD

ITGAE

881

P38570
DEMQAKGIPQRAPPK

PCMTD1

261

Q96MG8
PSPTMKEREKQQAPR

PDE4A

301

P27815
DRKPEYPKPDTQQMI

CSTF3

576

Q12996
PMENPALFNDIKIEP

KLF8

56

O95600
MKANNNVFEPKPSVP

KCNH4

191

Q9UQ05
QFSEIQMERQPPPLK

METTL7B

216

Q6UX53
GIPKDPFLNPDLMKN

GNG13

41

Q9P2W3
GKIQLPRPKMAPAND

IL10RA

141

Q13651
DPKVAFPRRAQPKMV

MSI1

91

O43347
MPAVSLPPKENALFK

NAA15

1

Q9BXJ9
NKDPEELFKQEMPPR

PPFIBP2

346

Q8ND30
DPQKPEPRDKMESFF

MAN1B1

646

Q9UKM7
PENRFLMRKSPPKAD

PPIG

281

Q13427
ELRENPPMKPDFSQL

ASF1B

121

Q9NVP2
EDPNPPITNLRMKAK

IL3RA

21

P26951
PNPCDMVKQPRYRKG

CACNA2D1

1041

P54289
AEAPAQAQKIPMPRV

GAS2L2

81

Q8NHY3
DPENAQKRSPMAFIP

CYP4F8

446

P98187
VPPPENVRMNSVNFK

IL10RB

21

Q08334
MEPFEINVPKPKRRN

MARCO

26

Q9UEW3
PRKDIKPDLQFMPRQ

CDH8

696

P55286
CKNMTRFQPPQAKDP

DEFB136

61

Q30KP8
MSEKENNFPPLPKFI

SCAMP4

1

Q969E2
MAEKVNNFPPLPKFI

SCAMP5

1

Q8TAC9
MEAFEQAERKPKPNP

BCKDHA

391

P12694
PAAMFRDPFRKDPNK

GLUL

81

P15104
SEPQHPKEKPFMFNL

PLEKHA2

401

Q9HB19
MNPEKDFAPLTPNIV

VAC14

1

Q08AM6
FPEPEAAQPMTKKRK

PRAME

146

P78395
PKEMNKLPANSPEAA

SLC6A5

6

Q9Y345
DIMEKLDQQIPPRPF

NXPE2

86

Q96DL1
QAKPRKDIDPFPQMA

RGS22

531

Q8NE09
PAGKMNNRDLKPQPD

NRXN3

491

Q9HDB5
QKLPPPNRDTMKVLF

ARHGAP15

396

Q53QZ3
KNNDMRKIPGYDPEP

NOM1

556

Q5C9Z4
KPIPRPANKFQGMVF

SCN3A

1506

Q9NY46
CFLMPKEQSVPNPEK

STK31

971

Q9BXU1
LNPRGIKPQKDPDMA

TSR1

311

Q2NL82
MEKQKPFALFVPPRS

SYCP1

1

Q15431
VPRLPPDEKKQMVAN

VTI1A

26

Q96AJ9
KPIPRPANKFQGMVF

SCN2A

1511

Q99250
EESKPKPRSFMPNLV

TNNT2

71

P45379
QVFPMNPPKFDKIED

MYH13

76

Q9UKX3
DKPPPRQKFIQSEMS

PRRC2B

486

Q5JSZ5
AVNPELFIKPNKPVM

SMIM8

36

Q96KF7
KPPFQANSPQDLRMF

ULK2

211

Q8IYT8
PPAKQLKEMPSVFQN

ZNF217

571

O75362
PQKQEPPEMELLKFF

TRAPPC8

1276

Q9Y2L5
MERPDKAALNALQPP

VMA21

1

Q3ZAQ7
AFPKPKDIPQAKEMF

TEX15

381

Q9BXT5
KKRLEPFMVQPNPEA

TULP3

41

O75386
PKRVHFPIPQADMDK

TGFBR3

671

Q03167
DNPKIMKQPPVKFDA

ULK4

426

Q96C45
FQEKKDPANPSPVMP

USP54

1026

Q70EL1