Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	BAH	TNRC18 BAHD1 BAHCC1	5.11e-06	11	60	3	SM00439
Domain	BAH	TNRC18 BAHD1 BAHCC1	5.11e-06	11	60	3	PF01426
Domain	BAH	TNRC18 BAHD1 BAHCC1	5.11e-06	11	60	3	PS51038
Domain	BAH_dom	TNRC18 BAHD1 BAHCC1	5.11e-06	11	60	3	IPR001025
Domain	LEM/LEM-like_dom	LEMD3 ANKLE2	2.11e-04	7	60	2	IPR011015
Domain	LEM_dom	LEMD3 ANKLE2	2.11e-04	7	60	2	IPR003887
Domain	LEM	LEMD3 ANKLE2	2.11e-04	7	60	2	PS50954
Domain	-	LEMD3 ANKLE2	2.11e-04	7	60	2	1.10.720.40
Domain	LEM	LEMD3 ANKLE2	2.11e-04	7	60	2	PF03020
Domain	PH-BEACH_dom	WDFY3 NSMAF	2.81e-04	8	60	2	IPR023362
Domain	-	WDFY3 NSMAF	2.81e-04	8	60	2	2.30.29.40
Domain	PH_BEACH	WDFY3 NSMAF	2.81e-04	8	60	2	PS51783
Domain	BEACH_dom	WDFY3 NSMAF	3.60e-04	9	60	2	IPR000409
Domain	BEACH	WDFY3 NSMAF	3.60e-04	9	60	2	PS50197
Domain	Beach	WDFY3 NSMAF	3.60e-04	9	60	2	PF02138
Domain	-	WDFY3 NSMAF	3.60e-04	9	60	2	1.10.1540.10
Domain	Beach	WDFY3 NSMAF	3.60e-04	9	60	2	SM01026
Domain	-	REXO5 RBMXL3 LEMD3 RNPS1 SRSF11	1.11e-03	244	60	5	3.30.70.330
Domain	Znf_FYVE_PHD	KMT2A RIMS1 WDFY3 KDM4B	1.28e-03	147	60	4	IPR011011
Domain	Nucleotide-bd_a/b_plait	REXO5 RBMXL3 LEMD3 RNPS1 SRSF11	1.42e-03	258	60	5	IPR012677
Domain	EPHD	KMT2A KDM4B	2.25e-03	22	60	2	PS51805
Domain	ZnF_U1	ZNF385D SCAPER	3.90e-03	29	60	2	SM00451
Domain	Znf_U1	ZNF385D SCAPER	3.90e-03	29	60	2	IPR003604
Domain	RRM_1	REXO5 RBMXL3 RNPS1 SRSF11	4.48e-03	208	60	4	PF00076
Domain	JMJC	RIOX1 KDM4B	4.73e-03	32	60	2	PS51184
Domain	JmjC_dom	RIOX1 KDM4B	4.73e-03	32	60	2	IPR003347
Domain	JmjC	RIOX1 KDM4B	5.03e-03	33	60	2	SM00558
Domain	RRM	REXO5 RBMXL3 RNPS1 SRSF11	5.20e-03	217	60	4	SM00360
Domain	Znf_FYVE-rel	RIMS1 WDFY3	5.33e-03	34	60	2	IPR017455
Domain	RRM_dom	REXO5 RBMXL3 RNPS1 SRSF11	6.09e-03	227	60	4	IPR000504
Domain	RRM	REXO5 RBMXL3 RNPS1 SRSF11	6.37e-03	230	60	4	PS50102
Domain	Znf_FYVE	RIMS1 WDFY3	6.62e-03	38	60	2	IPR000306
Domain	ZF_FYVE	RIMS1 WDFY3	7.32e-03	40	60	2	PS50178
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HIVEP3 TNRC18 DNAJC14 ZNRF3 ZNF592 SGSM2 NCAPD2 PER1 CARD10 WDFY3 REV3L PLXNB2 BAHD1 BAHCC1 TJP3	7.11e-10	1105	62	15	35748872
Pubmed	De novo genic mutations among a Chinese autism spectrum disorder cohort.	HIVEP3 RIMS1 WDFY3	1.17e-06	12	62	3	27824329
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	HIVEP3 CPAMD8 TNRC18 DENND1B NEIL1 SGSM2 ADGRG1 SRSF11 RIMS1 ARHGEF26 TET3 KDM4B NSMAF	1.80e-06	1489	62	13	28611215
Pubmed	Specificity of MLL1 and TET3 CXXC domains towards naturally occurring cytosine modifications.	KMT2A TET3	3.13e-06	2	62	2	30352306
Pubmed	Bimodal degradation of MLL by SCFSkp2 and APCCdc20 assures cell cycle execution: a critical regulatory circuit lost in leukemogenic MLL fusions.	KMT2A SKP2	9.37e-06	3	62	2	17908926
Pubmed	The sequence of the human genome.	ZNF385D TNRC18 DENND1B DNAJC14 ZNRF3 KMT2A TET3 NOBOX	1.16e-05	603	62	8	11181995
Pubmed	Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential.	SIN3B MXI1	1.87e-05	4	62	2	15467743
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	TNRC18 BCORL1 NCAPD2 KMT2A ADGRG1 RIMS1	2.79e-05	331	62	6	19490893
Pubmed	Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131.	SIN3B TNRC18 KMT2A BAHCC1	4.59e-05	110	62	4	26841866
Pubmed	Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation.	SIN3B PER1	4.67e-05	6	62	2	15226430
Pubmed	Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.	KMT2A SKP2	6.53e-05	7	62	2	20818375
Pubmed	Promoter occupancy of MLL1 histone methyltransferase seems to specify the proliferative and apoptotic functions of E2F1 in a tumour microenvironment.	KMT2A SKP2	8.69e-05	8	62	2	23868976
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	SIN3B MXI1	8.69e-05	8	62	2	8617250
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	VPS13D SCAPER BAHD1 BAHCC1	8.79e-05	130	62	4	12421765
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SIN3B ZNF592 RNPS1 BCORL1 MLH1 KMT2A KDM4B	1.03e-04	608	62	7	36089195
Pubmed	DNA Sequence Recognition of Human CXXC Domains and Their Structural Determinants.	KMT2A TET3	1.39e-04	10	62	2	29276034
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ZNRF3 ZNF592 RNPS1 SCAPER PER1 MLH1 WDFY3 REV3L BAHCC1	1.54e-04	1116	62	9	31753913
Pubmed	Human RNPS1 and its associated factors: a versatile alternative pre-mRNA splicing regulator in vivo.	RNPS1 SRSF11	1.70e-04	11	62	2	14729963
Pubmed	Plexin-B1 directly interacts with PDZ-RhoGEF/LARG to regulate RhoA and growth cone morphology.	KMT2A PLXNB2	2.04e-04	12	62	2	12123608
Pubmed	Amelogenesis imperfecta in a new animal model--a mutation in chromosome 5 (human 4q21).	TNRC18 WDFY3	2.04e-04	12	62	2	15271968
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	SIN3B TNRC18 BAHCC1	2.08e-04	64	62	3	22865885
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	TNRC18 RNPS1 NCAPD2 KMT2A SRSF11 RIMS1 ATP1A4 ANKLE2 ZNF541 BAHCC1	2.19e-04	1442	62	10	35575683
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	HIVEP3 SIN3B VPS13D TNRC18 SCAPER PER1	2.47e-04	493	62	6	15368895
Pubmed	A High-Density Map for Navigating the Human Polycomb Complexome.	SIN3B REXO5 BCORL1 KMT2A SKP2 MXI1	2.53e-04	495	62	6	27705803
Pubmed	Tet1 controls meiosis by regulating meiotic gene expression.	MLH1 TET3	2.81e-04	14	62	2	23151479
Pubmed	Mouse Sin3A interacts with and can functionally substitute for the amino-terminal repression of the Myc antagonist Mxi1.	SIN3B MXI1	3.69e-04	16	62	2	8649810
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	SIN3B LEMD3 RNPS1 BCORL1 KMT2A HMGN1 SRSF11 TET3 MXI1	4.57e-04	1294	62	9	30804502
Pubmed	Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.	SIN3B MXI1	4.70e-04	18	62	2	8521822
Pubmed	Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis.	MLH1 ZNF541	4.70e-04	18	62	2	34075040
Pubmed	Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.	NEIL1 DGCR8	4.70e-04	18	62	2	19047128
Pubmed	Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.	MLH1 NOBOX	5.24e-04	19	62	2	21478856
Pubmed	Identification and developmental analysis of genes expressed by dopaminergic neurons of the substantia nigra pars compacta.	HIVEP3 KMT2A TET3	5.67e-04	90	62	3	15033168
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2A KDM4B	6.42e-04	21	62	2	27626377
Pubmed	Genome-wide association study of chronic periodontitis in a general German population.	ZNF385D BCORL1 KDM4B	6.85e-04	96	62	3	24024966
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	TNRC18 BCORL1 SKP2 KDM4B BAHCC1	7.25e-04	398	62	5	35016035
Pubmed	Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.	MXI1 DNTT	7.72e-04	23	62	2	9143490
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	TRIL SIN3B ANKLE2	8.17e-04	102	62	3	9734811
Pubmed	Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.	MLH1 TET3	8.41e-04	24	62	2	23920106
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	ZNF592 LEMD3 RNPS1 BCORL1 KMT2A KDM4B	1.01e-03	645	62	6	25281560
Pubmed	Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.	MLH1 REV3L	1.15e-03	28	62	2	19661089
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	RNPS1 NEIL1 PI4KB MLH1 HMGN1 SPOCD1 PLXNB2	1.27e-03	925	62	7	28986522
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	SIN3B TNRC18 RNPS1 KMT2A	1.35e-03	268	62	4	33640491
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	LEMD3 BCORL1 KMT2A HMGN1 SRSF11 DGCR8 CWC25	1.51e-03	954	62	7	36373674
Pubmed	High-resolution recombinational map of mouse chromosome 16.	HMGN1 DGCR8	1.59e-03	33	62	2	9244437
Pubmed	The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.	MXI1 DNTT	1.59e-03	33	62	2	32140074
Interaction	TOP3B interactions	HIVEP3 TNRC18 DNAJC14 ZNRF3 ZNF592 SGSM2 NCAPD2 PER1 HMGN1 CARD10 WDFY3 REV3L PLXNB2 BAHD1 BAHCC1 TJP3	4.09e-06	1470	60	16	int:TOP3B
GeneFamily	LEM domain containing	LEMD3 ANKLE2	1.26e-04	7	45	2	1087
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDFY3 NSMAF	2.16e-04	9	45	2	1230
GeneFamily	Zinc fingers CXXC-type	KMT2A TET3	3.94e-04	12	45	2	136
GeneFamily	DNA polymerases	REV3L DNTT	1.48e-03	23	45	2	535
GeneFamily	Calcium voltage-gated channel subunits\|Membrane associated guanylate kinases	CARD10 TJP3	1.90e-03	26	45	2	904
Coexpression	GSE6674_PL2_3_VS_ANTI_IGM_AND_CPG_STIM_BCELL_DN	REXO5 ZNRF3 CA13 REV3L ANKLE2 MXI1	7.89e-06	200	62	6	M6943
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNRC18 ZNF592 NCAPD2 BAHD1 BAHCC1	3.41e-06	165	62	5	436ce4bc75e1ba4351c439ccad19f84ad5bcb92f
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Macrophage-macrophage,_alveolar\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNRC18 ZNF592 NCAPD2 BAHD1 BAHCC1	3.41e-06	165	62	5	242bdb7654f415391fb8e9bdc06412c7eee9c97e
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	VPS13D SCAPER KMT2A WDFY3 MXI1	4.81e-06	177	62	5	e8ab340b20cd41554c3841fe980e078e878af35f
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	VPS13D GJD2 SRSF11 DGCR8 KDM4B BAHCC1 TJP3	9.59e-07	197	61	7	7500_UP
Drug	5224221; Down 200; 12uM; MCF7; HT_HG-U133A_EA	SRSF11 CARD10 ARHGEF26 SKP2 BAHCC1 TJP3	1.05e-05	186	61	6	839_DN
Drug	Corticosterone [50-22-6]; Down 200; 11.6uM; HL60; HT_HG-U133A	ZNF592 SGSM2 PI4KB SCAPER BAHD1 KDM4B	1.33e-05	194	61	6	1307_DN
Drug	Sulfacetamide sodic hydrate [6209-17-2]; Down 200; 15.8uM; HL60; HT_HG-U133A	VPS13D DENND1B SCAPER PER1 WDFY3 KDM4B	1.37e-05	195	61	6	1859_DN
Drug	sulindac; Down 200; 100uM; MCF7; HG-U133A	HIVEP3 CHST5 REXO5 KMT2A KDM4B BAHCC1	1.45e-05	197	61	6	168_DN
Drug	Imipenem [74431-23-5]; Down 200; 13.4uM; PC3; HT_HG-U133A	ZNF385D SIN3B SCAPER PER1 DGCR8 BAHD1	1.50e-05	198	61	6	7294_DN
Drug	Eserine sulfate, physostigmine sulfate [64-47-1]; Up 200; 6.2uM; PC3; HT_HG-U133A	HIVEP3 CHST5 SCAPER PER1 SKP2 TJP3	1.54e-05	199	61	6	5749_UP
Drug	Talampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; HL60; HT_HG-U133A	SGSM2 SCAPER DGCR8 WDFY3 REV3L SKP2	1.58e-05	200	61	6	2954_DN
Drug	Dipyrone [5907-38-0]; Down 200; 12uM; MCF7; HT_HG-U133A	SCAPER KMT2A ANKLE2 SKP2 KDM4B	1.64e-04	192	61	5	3929_DN
Drug	Gallamine triethiodide [65-29-2]; Down 200; 4.4uM; HL60; HG-U133A	VPS13D DGCR8 ANKLE2 SKP2 KDM4B	1.68e-04	193	61	5	1375_DN
Drug	Bromperidol [10457-90-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A	HIVEP3 CHST5 DGCR8 INPP5J BAHCC1	1.68e-04	193	61	5	2872_UP
Drug	oxaprozin; Up 200; 300uM; MCF7; HT_HG-U133A_EA	BCORL1 PER1 KMT2A WDFY3 SKP2	1.68e-04	193	61	5	971_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; PC3; HT_HG-U133A	SGSM2 PER1 DGCR8 INPP5J KDM4B	1.68e-04	193	61	5	4322_UP
Drug	Imipramine hydrochloride [113-52-0]; Down 200; 12.6uM; MCF7; HT_HG-U133A	VPS13D SGSM2 PI4KB DGCR8 WDFY3	1.68e-04	193	61	5	5440_DN
Drug	Talampicillin hydrochloride [39878-70-1]; Down 200; 7.8uM; MCF7; HT_HG-U133A	SGSM2 PI4KB REV3L ANKLE2 KDM4B	1.68e-04	193	61	5	7014_DN
Drug	Rapamycin; Down 200; 0.1uM; HL60; HT_HG-U133A	VPS13D ZNF592 SGSM2 SCAPER CWC25	1.72e-04	194	61	5	6201_DN
Drug	Verapamyl hydrochloride [152-11-4]; Down 200; 8.2uM; HL60; HG-U133A	VPS13D SRSF11 DGCR8 BAHD1 KDM4B	1.72e-04	194	61	5	2009_DN
Drug	LY 294002; Up 200; 10uM; HL60; HT_HG-U133A	ZNF385D KMT2A DGCR8 SKP2 KDM4B	1.77e-04	195	61	5	2699_UP
Drug	(-)-Isoproterenol hydrochloride [5984-95-2]; Down 200; 16.2uM; PC3; HT_HG-U133A	PI4KB SCAPER PER1 DGCR8 KDM4B	1.77e-04	195	61	5	4495_DN
Drug	Pilocarpine nitrate [148-72-1]; Up 200; 14.8uM; MCF7; HT_HG-U133A	VPS13D NEIL1 PER1 SKP2 BAHCC1	1.77e-04	195	61	5	3300_UP
Drug	Glipizide [29094-61-9]; Up 200; 9uM; MCF7; HT_HG-U133A	HIVEP3 BCORL1 SCAPER REV3L BAHCC1	1.81e-04	196	61	5	1508_UP
Drug	(S)-(-)-Cycloserine [339-72-0]; Down 200; 39.2uM; PC3; HT_HG-U133A	HIVEP3 ZNF385D VPS13D WDFY3 SKP2	1.81e-04	196	61	5	3789_DN
Drug	Liothyronine [6893-02-3]; Down 200; 6.2uM; MCF7; HT_HG-U133A	HIVEP3 BCORL1 ADGRG1 BAHD1 TJP3	1.81e-04	196	61	5	3324_DN
Drug	Ronidazole [7681-76-7]; Up 200; 20uM; PC3; HT_HG-U133A	REXO5 BCORL1 SCAPER PER1 BAHCC1	1.81e-04	196	61	5	7131_UP
Drug	Ampyrone [83-07-8]; Up 200; 19.6uM; PC3; HT_HG-U133A	ZNF385D VPS13D BCORL1 KMT2A BAHCC1	1.81e-04	196	61	5	2086_UP
Drug	Benfotiamine [22457-89-2]; Up 200; 8.6uM; MCF7; HT_HG-U133A	VPS13D SGSM2 KMT2A DGCR8 WDFY3	1.81e-04	196	61	5	3837_UP
Drug	LY 294002; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	SGSM2 DGCR8 WDFY3 SKP2 PLXNB2	1.81e-04	196	61	5	1054_DN
Drug	Cefixime [79350-37-1]; Up 200; 8.8uM; HL60; HT_HG-U133A	VPS13D BCORL1 SCAPER PER1 BAHCC1	1.85e-04	197	61	5	1310_UP
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Down 200; 5.2uM; MCF7; HT_HG-U133A	VPS13D SCAPER DGCR8 WDFY3 INPP5J	1.85e-04	197	61	5	5449_DN
Drug	Scopolamin-N-oxide hydrobromide [6106-81-6]; Down 200; 10uM; MCF7; HT_HG-U133A	VPS13D SCAPER WDFY3 INPP5J TJP3	1.85e-04	197	61	5	5436_DN
Drug	Fusaric acid [536-69-6]; Down 200; 22.4uM; HL60; HT_HG-U133A	PI4KB SCAPER WDFY3 CWC25 SKP2	1.85e-04	197	61	5	1308_DN
Drug	Hydroxyzine dihydrochloride [2192-20-3]; Down 200; 9uM; PC3; HG-U133A	SGSM2 KMT2A ADGRG1 CWC25 SKP2	1.85e-04	197	61	5	1941_DN
Drug	Ketoconazole [65277-42-1]; Down 200; 7.6uM; MCF7; HT_HG-U133A	VPS13D BCORL1 PER1 ARHGEF26 BAHCC1	1.85e-04	197	61	5	5685_DN
Drug	Austricine [10180-88-8]; Up 200; 14.2uM; MCF7; HT_HG-U133A	CHST5 BCORL1 SCAPER PER1 DGCR8	1.85e-04	197	61	5	4797_UP
Drug	Praziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	GJD2 PER1 DGCR8 WDFY3 KDM4B	1.85e-04	197	61	5	3189_UP
Drug	Loracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A	VPS13D PI4KB SCAPER KDM4B TJP3	1.85e-04	197	61	5	3532_DN
Drug	Trimethylcolchicinic acid [3482-37-9]; Up 200; 11.6uM; MCF7; HT_HG-U133A	NEIL1 SCAPER WDFY3 KDM4B BAHCC1	1.85e-04	197	61	5	2802_UP
Drug	Viomycin sulfate [37883-00-4]; Up 200; 5.2uM; MCF7; HT_HG-U133A	SCAPER KMT2A CWC25 ARHGEF26 BAHCC1	1.85e-04	197	61	5	7036_UP
Drug	Naringenine [480-41-1]; Down 200; 14.6uM; HL60; HT_HG-U133A	HIVEP3 VPS13D SCAPER CWC25 KDM4B	1.85e-04	197	61	5	1342_DN
Drug	Suramin sodium salt; Up 200; 10uM; PC3; HT_HG-U133A	VPS13D REXO5 PI4KB DGCR8 BAHCC1	1.85e-04	197	61	5	7529_UP
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; HL60; HT_HG-U133A	VPS13D SGSM2 SCAPER KMT2A BAHCC1	1.90e-04	198	61	5	2356_DN
Drug	Bisoprolol fumarate; Down 200; 9uM; HL60; HT_HG-U133A	VPS13D BCORL1 KMT2A CWC25 SKP2	1.90e-04	198	61	5	1287_DN
Drug	Trimethobenzamide hydrochloride [554-92-7]; Up 200; 9.4uM; HL60; HG-U133A	HIVEP3 SCAPER SRSF11 DGCR8 KDM4B	1.90e-04	198	61	5	2002_UP
Drug	Piperidolate hydrochloride [129-77-1]; Down 200; 11.2uM; MCF7; HT_HG-U133A	HIVEP3 WDFY3 CWC25 BAHD1 TJP3	1.90e-04	198	61	5	3551_DN
Drug	Homochlorcyclizine dihydrochloride [1982-36-1]; Down 200; 10.4uM; MCF7; HT_HG-U133A	VPS13D ZNF592 SRSF11 CARD10 SKP2	1.90e-04	198	61	5	7417_DN
Drug	Panthenol (D) [81-13-0]; Down 200; 19.4uM; HL60; HT_HG-U133A	VPS13D SGSM2 PI4KB WDFY3 BAHCC1	1.90e-04	198	61	5	1844_DN
Drug	Riluzole hydrochloride; Down 200; 14.8uM; PC3; HT_HG-U133A	ZNF592 SCAPER DGCR8 ARHGEF26 BAHD1	1.94e-04	199	61	5	7365_DN
Drug	Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; MCF7; HT_HG-U133A	VPS13D BCORL1 SCAPER SKP2 BAHCC1	1.94e-04	199	61	5	6492_DN
Drug	Sulindac [38194-50-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	VPS13D SGSM2 PI4KB DGCR8 BAHD1	1.94e-04	199	61	5	1815_DN
Drug	tolbutamide; Down 200; 100uM; MCF7; HG-U133A	CHST5 BCORL1 SCAPER DGCR8 KDM4B	1.94e-04	199	61	5	142_DN
Drug	AG-013608 [351320-38-2]; Down 200; 10uM; PC3; HT_HG-U133A	HIVEP3 ZNF385D SCAPER DGCR8 KDM4B	1.94e-04	199	61	5	5949_DN
Drug	estradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A	VPS13D SCAPER WDFY3 INPP5J BAHCC1	1.94e-04	199	61	5	5601_DN
Drug	Amoxicillin [26787-78-0]; Down 200; 11uM; MCF7; HT_HG-U133A	PER1 ADGRG1 INPP5J KDM4B TJP3	1.94e-04	199	61	5	5385_DN
Drug	Trimethobenzamide hydrochloride [554-92-7]; Down 200; 9.4uM; PC3; HG-U133A	VPS13D SRSF11 CARD10 DGCR8 NSMAF	1.99e-04	200	61	5	1920_DN
Drug	Maprotiline hydrochloride [10347-81-6]; Down 200; 12.8uM; PC3; HT_HG-U133A	HIVEP3 VPS13D DGCR8 SKP2 BAHCC1	1.99e-04	200	61	5	6676_DN
Drug	Aminophylline [317-34-0]; Down 200; 9.6uM; HL60; HT_HG-U133A	PER1 WDFY3 ARHGEF26 BAHD1 TJP3	1.99e-04	200	61	5	3036_DN
Disease	Chediak-Higashi syndrome (implicated_via_orthology)	WDFY3 NSMAF	2.35e-05	4	59	2	DOID:2935 (implicated_via_orthology)
Disease	Neurodevelopmental Disorders	HIVEP3 KMT2A RIMS1 WDFY3	3.69e-05	93	59	4	C1535926
Disease	bitter alcoholic beverage consumption measurement	ZNF385D SCAPER TET3 BAHCC1	1.48e-04	133	59	4	EFO_0010092
Disease	treatment resistant depression, response to antidepressant	HIVEP3 ZNF385D	8.05e-04	21	59	2	EFO_0009854, GO_0036276
Disease	Bilateral Wilms Tumor	BCORL1 DGCR8	1.54e-03	29	59	2	C2930471
Disease	serum gamma-glutamyl transferase measurement	TRIL MLH1 KMT2A NSMAF MXI1 BAHCC1 TJP3	2.25e-03	914	59	7	EFO_0004532
Disease	Nephroblastoma	BCORL1 DGCR8	2.37e-03	36	59	2	C0027708
Disease	cups of coffee per day measurement	DENND1B ATP1A4	2.92e-03	40	59	2	EFO_0006782
Disease	cervix uteri carcinoma in situ (is_marker_for)	MLH1 SKP2	3.21e-03	42	59	2	DOID:8991 (is_marker_for)
Disease	Childhood Medulloblastoma	SKP2 KDM4B	3.37e-03	43	59	2	C0278510
Disease	Melanotic medulloblastoma	SKP2 KDM4B	3.37e-03	43	59	2	C1275668
Disease	Medullomyoblastoma	SKP2 KDM4B	3.37e-03	43	59	2	C0205833
Disease	Desmoplastic Medulloblastoma	SKP2 KDM4B	3.37e-03	43	59	2	C0751291
Disease	Adult Medulloblastoma	SKP2 KDM4B	3.37e-03	43	59	2	C0278876
Disease	immunoglobulin isotype switching measurement	ZNRF3 ATP1A4	3.52e-03	44	59	2	EFO_0010128
Disease	prostate cancer (is_marker_for)	KMT2A SKP2 KDM4B	3.79e-03	156	59	3	DOID:10283 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPKPRDKSRRSRSPL	PRPF4B	356	Q13523
ISSRRHKDRAAGKPP	ZNF385D	286	Q9H6B1
RGPGRPRKRKHSSSL	BAHCC1	1481	Q9P281
PRKRKHSSSLPAPRP	BAHCC1	1486	Q9P281
PSSRHRGPRSNLKKR	CARD10	781	Q9BWT7
NHSRTLAGKRPKAPR	ANKLE2	706	Q86XL3
RRSRSPRPSKLHNSK	CWC25	291	Q9NXE8
PHPSGLRTASKSKLR	GJD2	176	Q9UKL4
RSSHRPKCRKLPSDP	BCORL1	1141	Q5H9F3
YRAASPRLRRPKSPK	ARHGEF26	101	Q96DR7
HRPPQPLKGRKVRAS	CA13	246	Q8N1Q1
PRTARHAPAVRKFSP	DGCR8	96	Q8WYQ5
PPRSRAPHKDRTLAR	NOBOX	161	O60393
PRRTHSKPLPPLTAK	LEMD3	286	Q9Y2U8
VSSGKKPPSRRQRHR	DNAJC14	186	Q6Y2X3
PPSKAPSRTRRAKRD	NEIL1	316	Q96FI4
PSRSPRLGRPKAVSK	GPR179	1126	Q6PRD1
RRRRHKKPPSSVAPI	MSS51	6	Q4VC12
PAPPSRRHHCRSKAK	PER1	826	O15534
PPPKRRQKRDTTHNL	PLXNB2	1156	O15031
EIKKSRRHPLGRPPT	KDM4B	606	O94953
KSRRPLGKSPSEPAH	MPND	206	Q8N594
SESVRPSPPKPHRSK	RIMS1	506	Q86UR5
KHPSHKPRGRSLPRR	C5orf60	246	A6NFR6
APSRHPPRTEKRKRT	CPAMD8	731	Q8IZJ3
SKAARRPSHPKQPRV	BAHD1	561	Q8TBE0
KHPQKASRRPSAAPA	ADGRG1	191	Q9Y653
PHPRRITPKFKSLSQ	NSMAF	571	Q92636
HKRSPLLRAPRFTPS	KMT2A	691	Q03164
SHISRTLPKPRSKVP	KIAA1210	261	Q9ULL0
SALHGKHLPPSPRKR	DENND1B	636	Q6P3S1
KHLPPSPRKRVSSSG	DENND1B	641	Q6P3S1
SPTKTRHPRKIDLRA	SCAPER	86	Q9BY12
RKCPPSILKRSRPEH	NRAC	41	Q8N912
EPKRRSARLSAKPPA	HMGN1	16	P05114
RKRRSPSPKPTKVHI	RNPS1	151	Q15287
ASHLSPRKKRPRQTG	DNTT	6	P04053
GRPPRTLRPLSHAKS	SH2D5	401	Q6ZV89
SPAKRPALGIRKRHS	SGSM2	216	O43147
KTPEHSRKRSRPSLL	SIN3B	261	O75182
CDNPPSPSPRKRKRH	SPATA31C1	51	P0DKV0
KRGPTSSNPRKRHRE	MLH1	461	P40692
KPAHRKRELPSLSPA	PI4KB	246	Q9UBF8
PKRRRKPQPHSGSVL	RIOX1	16	Q9H6W3
APHDQSPRRRPKKGL	ATP1A4	11	Q13733
RVPKVAHSTRRPPAA	CHST5	6	Q9GZS9
NISDRRKPSLGKRHP	NCAPD2	821	Q15021
LSKCPQHPRPRRTKG	LINC00477	136	Q96M19
PKSRSPSPGKSKRHR	INPP5J	871	Q15735
HPESPPRKRLKSKGS	SKP2	61	Q13309
PGRPRKRTHAPSALS	TNRC18	1526	O15417
KRTHAPSALSPPRKR	TNRC18	1531	O15417
KPHPPKRVRSRLNGD	WDFY3	2971	Q8IZQ1
GPPHKRAVPRSSLAR	RBMXL3	201	Q8N7X1
FRKKRSHAILSPPSP	REV3L	1076	O60673
PKRKLSRSPSPRRHK	SRSF11	361	Q05519
RKAFRHKFRLPPPSS	REXO5	121	Q96IC2
SSPSPAQRLRRKKRP	SPOCD1	511	Q6ZMY3
SSVPPRQRLKPAHSK	ZNF592	266	Q92610
LHKKPQRGRPTRADP	TRIL	511	Q7L0X0
GSRPPLARKHSLTKN	HIVEP3	1976	Q5T1R4
TPLKKPNRCHPTRIS	TET3	1676	O43151
LKRPKACSPRSPQHT	nan	206	Q8N9P0
RPRRIHLPATKASPS	TJP3	91	O95049
SPAHPFRRPKLSGRS	ZNRF3	441	Q9ULT6
PAKPRSHPRKRDPTA	ZGLP1	26	P0C6A0
SHPRKRDPTALLPRS	ZGLP1	31	P0C6A0
SSPPRAAGHRPRKRK	nan	236	A6NL46
SPRERPSHHPTPKLK	ZNF541	1241	Q9H0D2
NCSKKPLRSRHSPRI	VPS13D	251	Q5THJ4
KPPRRLSRAQKHSSG	MXI1	46	P50539