Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	p53 binding	BRD4 TRIM24 EP300 AXIN1	1.09e-04	77	64	4	GO:0002039
GeneOntologyMolecularFunction	acetylation-dependent protein binding	BRD4 TRIM24 EP300	1.32e-04	31	64	3	GO:0140033
GeneOntologyMolecularFunction	histone binding	L3MBTL1 BRD4 SRCAP TRIM24 PHC1 PHC2	2.03e-04	265	64	6	GO:0042393
GeneOntologyMolecularFunction	transcription coactivator activity	KMT2C BRD4 SRCAP TRIM24 MAML3 EP300	4.16e-04	303	64	6	GO:0003713
GeneOntologyMolecularFunction	RNA polymerase II C-terminal domain binding	SCAF8 BRD4	5.46e-04	11	64	2	GO:0099122
GeneOntologyCellularComponent	chromatin	FOXD3 L3MBTL1 ATXN7 KLF5 BRD4 ETV5 RHOXF1 SRCAP ZHX2 TRIM24 TFCP2 EP300 PHC1 PHC2	1.25e-04	1480	64	14	GO:0000785
Domain	Bromodomain_CS	BRD4 TRIM24 EP300	9.43e-05	26	64	3	IPR018359
Domain	Znf_FCS	PHC1 PHC2	1.15e-04	5	64	2	IPR012313
Domain	Nuc_rcpt_coact	PALMD EP300	1.72e-04	6	64	2	IPR009110
Domain	ZF_FCS	PHC1 PHC2	1.72e-04	6	64	2	PS51024
Domain	BROMODOMAIN_1	BRD4 TRIM24 EP300	2.74e-04	37	64	3	PS00633
Domain	Bromodomain	BRD4 TRIM24 EP300	2.97e-04	38	64	3	PF00439
Domain	BROMODOMAIN_2	BRD4 TRIM24 EP300	3.73e-04	41	64	3	PS50014
Domain	BROMO	BRD4 TRIM24 EP300	4.00e-04	42	64	3	SM00297
Domain	Bromodomain	BRD4 TRIM24 EP300	4.00e-04	42	64	3	IPR001487
Domain	-	BRD4 TRIM24 EP300	4.00e-04	42	64	3	1.20.920.10
Domain	SAM/pointed	L3MBTL1 TFCP2 PHC1 PHC2	6.96e-04	117	64	4	IPR013761
Domain	Acyl_Trfase/lysoPLipase	FASN PLA2G4D	1.52e-03	17	64	2	IPR016035
Domain	SAM_1	L3MBTL1 PHC1 PHC2	1.64e-03	68	64	3	PF00536
Domain	SAM	L3MBTL1 PHC1 PHC2	3.42e-03	88	64	3	SM00454
Domain	AT_hook	KMT2C SRCAP	3.84e-03	27	64	2	SM00384
Domain	AT_hook_DNA-bd_motif	KMT2C SRCAP	3.84e-03	27	64	2	IPR017956
Domain	SAM_DOMAIN	L3MBTL1 PHC1 PHC2	4.24e-03	95	64	3	PS50105
Domain	SAM	L3MBTL1 PHC1 PHC2	4.50e-03	97	64	3	IPR001660
Domain	-	L3MBTL1 PHC1 PHC2	5.76e-03	106	64	3	1.10.150.50
Pathway	WP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA	MAGI1 KMT2C INSRR SRCAP MAML3 EP300	9.09e-08	65	49	6	M39682
Pathway	WP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY	FOXD3 NACC1 KLF5 ETV5 TRIM24 EP300 INS-IGF2 PHC1 AXIN1	7.94e-07	301	49	9	MM15983
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	EP300 PHC1 PHC2	2.19e-04	34	49	3	MM15531
Pathway	REACTOME_RUNX1_INTERACTS_WITH_CO_FACTORS_WHOSE_PRECISE_EFFECT_ON_RUNX1_TARGETS_IS_NOT_KNOWN	EP300 PHC1 PHC2	2.82e-04	37	49	3	M27797
Pathway	REACTOME_SUMOYLATION_OF_TRANSCRIPTION_COFACTORS	EP300 PHC1 PHC2	3.56e-04	40	49	3	MM15000
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	MAGI1 EVA1C KMT2C AMER1 ATXN7 SCAF8 FRMPD1 FBXL17 CACNA1H RILPL1 ZHX2 MAML3 EP300 WNK2	6.27e-07	1489	66	14	28611215
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	ATXN2L KMT2C FASN WIPF1 RBM33 NACC1 KLF5 BRD4 ETV5 SNRPA TRIM24 EP300	9.90e-07	1103	66	12	34189442
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KMT2C FASN SSH1 BRD4 LRRC56 CACNA1H ATG2A SRCAP PRAG1 EP300 WNK2 PHC2	1.01e-06	1105	66	12	35748872
Pubmed	Human transcription factor protein interaction networks.	KMT2C DCP1B RBM33 ATXN7 NACC1 SCAF8 KLF5 ETV5 SRCAP ZHX2 TRIM24 TFCP2 EP300	2.42e-06	1429	66	13	35140242
Pubmed	Fatty acid synthase expression associated with NAC1 is a potential therapeutic target in ovarian clear cell carcinomas.	FASN NACC1	3.55e-06	2	66	2	22653145
Pubmed	P300 acetyltransferase regulates fatty acid synthase expression, lipid metabolism and prostate cancer growth.	FASN EP300	3.55e-06	2	66	2	26934656
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	AMER1 DCP1B RBM33 NACC1 KLF5 PALMD PLEKHA6 ATG2A SNRPA TFCP2 AXIN1	3.80e-06	1038	66	11	26673895
Pubmed	Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain.	KLF5 EP300	1.06e-05	3	66	2	14612398
Pubmed	Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.	PHC1 PHC2	1.06e-05	3	66	2	17215307
Pubmed	Brd4-p300 inhibition downregulates Nox4 and accelerates lung fibrosis resolution in aged mice.	BRD4 EP300	1.06e-05	3	66	2	32544088
Pubmed	Oncogenesis by sequestration of CBP/p300 in transcriptionally inactive hyperacetylated chromatin domains.	BRD4 EP300	1.06e-05	3	66	2	20676058
Pubmed	Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.	BRD4 EP300	1.06e-05	3	66	2	28262505
Pubmed	The deacetylase HDAC1 negatively regulates the cardiovascular transcription factor Krüppel-like factor 5 through direct interaction.	KLF5 EP300	1.06e-05	3	66	2	15668237
Pubmed	Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein.	SRCAP EP300	1.06e-05	3	66	2	10347196
Pubmed	Identification and characterization of interactions between the vertebrate polycomb-group protein BMI1 and human homologs of polyhomeotic.	PHC1 PHC2	1.06e-05	3	66	2	9121482
Pubmed	Promoter-bound p300 complexes facilitate post-mitotic transmission of transcriptional memory.	BRD4 EP300	1.06e-05	3	66	2	24945803
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	KMT2C NACC1 KLF5 TFCP2 PHC1	1.70e-05	167	66	5	20362541
Pubmed	MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.	KMT2C EP300	2.12e-05	4	66	2	28398509
Pubmed	Adenovirus DNA binding protein interacts with the SNF2-related CBP activator protein (SrCap) and inhibits SrCap-mediated transcription.	SRCAP EP300	2.12e-05	4	66	2	11581372
Pubmed	Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1.	BRD4 EP300	2.12e-05	4	66	2	30428346
Pubmed	Significance of the transcription factor KLF5 in cardiovascular remodeling.	KLF5 EP300	2.12e-05	4	66	2	16102021
Pubmed	Regulation of hypoxia-inducible factor 1α (HIF-1α) by lysophosphatidic acid is dependent on interplay between p53 and Krüppel-like factor 5.	KLF5 EP300	2.12e-05	4	66	2	23880760
Pubmed	NSD3-NUT fusion oncoprotein in NUT midline carcinoma: implications for a novel oncogenic mechanism.	BRD4 EP300	2.12e-05	4	66	2	24875858
Pubmed	Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection.	BRD4 EP300	2.12e-05	4	66	2	35716662
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	KMT2C DCP1B RBM33 SCAF8 TRIM24 MAML3 EP300	2.58e-05	457	66	7	32344865
Pubmed	RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor.	PHC1 PHC2	3.53e-05	5	66	2	9199346
Pubmed	Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain.	TRIM24 EP300	3.53e-05	5	66	2	11931765
Pubmed	A human MAP kinase interactome.	MAGI1 KMT2C WIPF1 RBM33 PLEKHA6 EP300 WNK2	3.81e-05	486	66	7	20936779
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	MAGI1 NRG1 KMT2C CTU2 SNRPA TRIM24 TFCP2 PHC1	4.76e-05	689	66	8	36543142
Pubmed	A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.	L3MBTL1 ATXN7	5.29e-05	6	66	2	23652004
Pubmed	Lipopolysaccharide modulates p300 and Sirt1 to promote PRMT1 stability via an SCFFbxl17-recognized acetyldegron.	FBXL17 EP300	5.29e-05	6	66	2	28883095
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	KMT2C FOXD3 KLF5 BRD4 RNF44 ETV5 MAML3 PHC1	5.81e-05	709	66	8	22988430
Pubmed	Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor.	RBM33 NACC1 TRIM24 EP300	6.52e-05	113	66	4	23403292
Pubmed	cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice.	MIA2 INS-IGF2	7.40e-05	7	66	2	29133483
Pubmed	A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia.	NRG1 SSH1	7.40e-05	7	66	2	15159416
Pubmed	MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1.	PHC1 PHC2	7.40e-05	7	66	2	15563468
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KMT2C ATXN7 ETV5 WNK2 AXIN1	8.28e-05	233	66	5	37704626
Pubmed	MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells.	PHC1 PHC2	9.86e-05	8	66	2	19369945
Pubmed	The methyltransferase SMYD3 mediates the recruitment of transcriptional cofactors at the myostatin and c-Met genes and regulates skeletal muscle atrophy.	BRD4 EP300	9.86e-05	8	66	2	23752591
Pubmed	Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas.	FOXD3 INS-IGF2	9.86e-05	8	66	2	16750430
Pubmed	Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells.	KLF5 EP300	9.86e-05	8	66	2	19419955
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATXN2L FASN SSH1 ATXN7 NACC1 SCAF8 BRD4 PHC2	1.07e-04	774	66	8	15302935
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	KMT2C BRD4 ZHX2 TRIM24 TFCP2 EP300	1.10e-04	398	66	6	35016035
Pubmed	Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice.	FASN CRH	1.27e-04	9	66	2	9922208
Pubmed	Decreased fetal size is associated with beta-cell hyperfunction in early life and failure with age.	FASN INS-IGF2	1.27e-04	9	66	2	18591393
Pubmed	MAP3K1 functionally interacts with Axin1 in the canonical Wnt signalling pathway.	AMER1 AXIN1	1.27e-04	9	66	2	20128690
Pubmed	RYBP-PRC1 complexes mediate H2A ubiquitylation at polycomb target sites independently of PRC2 and H3K27me3.	PHC1 PHC2	1.27e-04	9	66	2	22325148
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	KLF5 BRD4 ETV5 SRCAP TRIM24 PRR3 TFCP2 PHC1	1.43e-04	808	66	8	20412781
Pubmed	A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.	ATXN2L ATXN7 RHOXF1 ZHX2 TFCP2 WNK2 PHC2	1.54e-04	608	66	7	16713569
Pubmed	Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.	TRIM24 EP300	1.58e-04	10	66	2	30595551
Pubmed	A role for neuregulin1 signaling in muscle spindle differentiation.	NRG1 ETV5	1.58e-04	10	66	2	12495620
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	KMT2C NACC1 KLF5 PHC1	1.75e-04	146	66	4	23892456
Pubmed	Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.	PHC1 PHC2	1.93e-04	11	66	2	12183370
Pubmed	Mammalian polyhomeotic homologues Phc2 and Phc1 act in synergy to mediate polycomb repression of Hox genes.	PHC1 PHC2	1.93e-04	11	66	2	16024804
Pubmed	Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus.	PHC1 PHC2	2.31e-04	12	66	2	19636380
Pubmed	Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex.	AMER1 AXIN1	2.31e-04	12	66	2	22682247
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	SRCAP EP300 PHC1 PHC2	2.32e-04	157	66	4	30186101
Pubmed	Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.	ATXN7 EP300	2.73e-04	13	66	2	15932940
Pubmed	Overexpression of Polycomb-group gene rae28 in cardiomyocytes does not complement abnormal cardiac morphogenesis in mice lacking rae28 but causes dilated cardiomyopathy.	PHC1 PHC2	2.73e-04	13	66	2	11950896
Pubmed	Genetic interaction mapping in mammalian cells using CRISPR interference.	SRCAP PHC1 PHC2	3.13e-04	69	66	3	28481362
Pubmed	Regulation of the ERK signalling pathway in the developing mouse blastocyst.	KLF5 ETV5	3.18e-04	14	66	2	31320324
Pubmed	Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.	FASN INS-IGF2	3.18e-04	14	66	2	25249504
Pubmed	Multiplexed molecular interactions of nuclear receptors using fluorescent microspheres.	TRIM24 EP300	3.18e-04	14	66	2	11500849
Pubmed	TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1.	TRIM24 EP300	3.18e-04	14	66	2	11331592
Pubmed	Enzymatic nucleosome acetylation selectively affects activity of histone methyltransferases in vitro.	KMT2C EP300	3.67e-04	15	66	2	35907431
Pubmed	Essential role of MESP1-RING1A complex in cardiac differentiation.	EP300 PHC1	3.67e-04	15	66	2	36413948
Pubmed	Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor.	PHC1 PHC2	3.67e-04	15	66	2	20601937
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	BRD4 TRIM24 EP300	4.00e-04	75	66	3	25593309
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	ATXN2L ACSL6 SRCAP	4.16e-04	76	66	3	36560452
Pubmed	SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.	KMT2C EP300	4.18e-04	16	66	2	23870121
Pubmed	The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans.	PHC1 PHC2	4.18e-04	16	66	2	12167701
Pubmed	Role of histone H2A ubiquitination in Polycomb silencing.	PHC1 PHC2	4.18e-04	16	66	2	15386022
Pubmed	Vascular endothelial growth factor coordinates islet innervation via vascular scaffolding.	FOXD3 INS-IGF2	4.74e-04	17	66	2	24574008
Pubmed	Wilms tumor suppressor WTX negatively regulates WNT/beta-catenin signaling.	AMER1 AXIN1	4.74e-04	17	66	2	17510365
Pubmed	Influence and timing of arrival of murine neural crest on pancreatic beta cell development and maturation.	FOXD3 INS-IGF2	4.74e-04	17	66	2	21081123
Pubmed	Global deficits in development, function, and gene expression in the endocrine pancreas in a deletion mouse model of Prader-Willi syndrome.	SNRPA INS-IGF2	5.32e-04	18	66	2	21343540
Pubmed	Loss of Wiz Function Affects Methylation Pattern in Palate Development and Leads to Cleft Palate.	ETV5 AXIN1	5.94e-04	19	66	2	34150743
Pubmed	Mammalian polycomb-mediated repression of Hox genes requires the essential spliceosomal protein Sf3b1.	PHC1 PHC2	5.94e-04	19	66	2	15741318
Pubmed	Acetylation-regulated interaction between p53 and SET reveals a widespread regulatory mode.	BRD4 EP300	5.94e-04	19	66	2	27626385
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	ATXN2L KMT2C FASN BRD4 SRCAP EP300	6.14e-04	549	66	6	38280479
Pubmed	Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor.	ENAM ETV5	6.59e-04	20	66	2	28650075
Pubmed	T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.	TRIM24 EP300	6.59e-04	20	66	2	11877444
Pubmed	A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects.	ATXN7 AXIN1	6.59e-04	20	66	2	34127677
Pubmed	Lgi4 promotes the proliferation and differentiation of glial lineage cells throughout the developing peripheral nervous system.	NRG1 ETV5	6.59e-04	20	66	2	21068328
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ATXN2L L3MBTL1 NECAB3 TFCP2 AXIN1 PHC2	6.80e-04	560	66	6	21653829
Pubmed	A multipotent progenitor domain guides pancreatic organogenesis.	FOXD3 BRD4 ETV5	7.04e-04	91	66	3	17609113
Pubmed	SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions.	PHC1 PHC2	7.28e-04	21	66	2	37014752
Pubmed	PRC1 and Suv39h specify parental asymmetry at constitutive heterochromatin in early mouse embryos.	PHC1 PHC2	7.28e-04	21	66	2	18311137
Pubmed	Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.	ATXN2L FBXL17 RILPL1	7.73e-04	94	66	3	25201988
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	NRG1 FASN SCAF8 BRD4 SNRPA RNF17	8.31e-04	582	66	6	20467437
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	RBM33 ATXN7 BRD4 TRIM24	8.54e-04	222	66	4	37071664
Pubmed	A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.	NRG1 ETV5	8.75e-04	23	66	2	29532549
Pubmed	cDNAs with long CAG trinucleotide repeats from human brain.	MAGI1 MAML3	8.75e-04	23	66	2	9225980
Pubmed	Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ACSL6 ZHX2 MYO16	9.25e-04	100	66	3	10048485
Pubmed	Spatiotemporal-resolved protein networks profiling with photoactivation dependent proximity labeling.	ATXN2L RBM33 BRD4 SNRPA ZHX2	9.76e-04	399	66	5	35987950
Pubmed	Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression.	ATXN2L SCAF8 BRD4 SNRPA PRR3	1.02e-03	403	66	5	35253629
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ACSL6 SCAF8 FRMPD1 CACNA1H ZHX2	1.07e-03	407	66	5	12693553
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	FOXD3 FASN NACC1 FRMPD1 TRIM24 TFCP2 EP300	1.19e-03	857	66	7	25609649
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	FASN NACC1 BRD4 TRIM24 PHC1	1.20e-03	418	66	5	34709266
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	HMCN2 ATXN7 NACC1 BRD4 SRCAP TRIM24 PRR3 EP300	1.21e-03	1116	66	8	31753913
Interaction	SUMO1 interactions	ATXN7 KLF5 BRD4 TRIM24 TFCP2 EP300 PHC1 AXIN1	3.40e-06	287	64	8	int:SUMO1
Interaction	EDC3 interactions	MAGI1 ATXN2L FASN DCP1B BRD4 EP300	1.21e-05	161	64	6	int:EDC3
Interaction	BZW1 interactions	MAGI1 FASN BRD4 CMYA5 SNRPA EP300	2.50e-05	183	64	6	int:BZW1
Interaction	SCMH1 interactions	BRD4 MAML3 PHC1 PHC2	2.60e-05	54	64	4	int:SCMH1
Interaction	KLF5 interactions	KMT2C KLF5 BRD4 ZHX2 TRIM24 EP300	3.57e-05	195	64	6	int:KLF5
Interaction	HIC2 interactions	FASN BRD4 RNF44 EP300	4.21e-05	61	64	4	int:HIC2
Interaction	TOP3B interactions	KMT2C FASN SSH1 RBM33 BRD4 LRRC56 CACNA1H ATG2A SRCAP SNRPA PRAG1 TFCP2 EP300 WNK2 PHC2	4.33e-05	1470	64	15	int:TOP3B
Interaction	BCOR interactions	L3MBTL1 NACC1 KLF5 BRD4 IL17RA PHC1 PHC2	4.73e-05	302	64	7	int:BCOR
Interaction	SRCAP interactions	SRCAP TRIM24 EP300 PHC1 PHC2	5.20e-05	127	64	5	int:SRCAP
Interaction	WDR82 interactions	ATXN2L KMT2C FASN BRD4 SNRPA EP300	5.84e-05	213	64	6	int:WDR82
Interaction	YY1 interactions	ATXN2L FASN BRD4 SRCAP ZHX2 TRIM24 TFCP2 EP300	9.14e-05	454	64	8	int:YY1
Interaction	PPHLN1 interactions	FASN L3MBTL1 BRD4 SNRPA PRR3	1.01e-04	146	64	5	int:PPHLN1
Interaction	UBP1 interactions	FOXD3 FASN BRD4 TFCP2	1.16e-04	79	64	4	int:UBP1
GeneFamily	Sterile alpha motif domain containing	L3MBTL1 PHC1 PHC2	1.28e-03	88	44	3	760
GeneFamily	Ataxins\|Trinucleotide repeat containing	MAGI1 MAML3	1.68e-03	25	44	2	775
CoexpressionAtlas	FacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#3	NRG1 AMER1 ATXN7 KLF5 ETV5 ATG2A ZHX2	3.63e-05	305	64	7	Facebase_RNAseq_e9.5_Maxillary Arch_2500_K3
Drug	Naloxone hydrochloride [357-08-4]; Up 200; 11uM; HL60; HG-U133A	ATXN2L SSH1 ATXN7 ETV5 SRCAP CRH AXIN1	1.24e-06	198	63	7	2006_UP
Drug	AC1L2FXT	BRD4 PHC1 PHC2	2.39e-06	10	63	3	CID000071316
Drug	AC1L2XIZ	BRD4 PHC1 PHC2	4.36e-06	12	63	3	CID000104803
Drug	Ivermectin [70288-86-7]; Up 200; 4.6uM; MCF7; HT_HG-U133A	MIA2 L3MBTL1 FRMPD1 ETV5 SRCAP SH3D21	1.39e-05	189	63	6	7206_UP
Disease	Adenoid Cystic Carcinoma	MAGI1 KMT2C INSRR SRCAP MAML3 EP300	7.57e-08	100	63	6	C0010606
Disease	Etat Marbre	NRG1 ATXN7 CRH	1.59e-05	23	63	3	C0266487
Disease	Movement Disorders	NRG1 ATXN7 CRH	3.26e-05	29	63	3	C0026650
Disease	cortical surface area measurement	MAGI1 ATXN2L ACSL6 ZNF474 FBXL17 PRR3 MYO16 INS-IGF2 WNK2 AXIN1 PHC2	1.18e-04	1345	63	11	EFO_0010736
Disease	pulse pressure measurement	EVA1C NRG1 FASN TTBK1 WIPF1 RBM33 ATXN7 PSORS1C1 FBXL17 SRCAP PHC2	1.59e-04	1392	63	11	EFO_0005763
Disease	testosterone measurement	MAGI1 ATXN2L FASN TTBK1 AMER1 SPEM3 GDF6 SRCAP MYO16 INS-IGF2	3.47e-04	1275	63	10	EFO_0004908
Disease	Alopecia, Male Pattern	BRD4 CRH	4.63e-04	15	63	2	C4083212
Disease	Androgenetic Alopecia	BRD4 CRH	4.63e-04	15	63	2	C0162311
Disease	Female pattern alopecia (disorder)	BRD4 CRH	4.63e-04	15	63	2	C0263477
Disease	Schizophrenia	MAGI1 ACSL6 NRG1 KLF5 PLEKHA6 CMYA5 CRH MYO16	5.63e-04	883	63	8	C0036341
Disease	Pseudopelade	BRD4 CRH	7.49e-04	19	63	2	C0086873
Disease	Alopecia	BRD4 CRH	7.49e-04	19	63	2	C0002170
Disease	Adenocarcinoma of lung (disorder)	FASN KLF5 INSRR EP300	9.96e-04	206	63	4	C0152013
Disease	gamma-glutamylglutamine measurement	NRG1 MAML3	1.01e-03	22	63	2	EFO_0021138
Disease	Squamous cell carcinoma of esophagus	KMT2C FASN EP300	1.12e-03	95	63	3	C0279626
Disease	creatinine measurement	NRG1 ATXN7 SCAF8 PSORS1C1 ETV5 FBXL17 INS-IGF2 PHC2	1.22e-03	995	63	8	EFO_0004518
Disease	tyrosine measurement	NRG1 TTBK1 PRAG1	1.45e-03	104	63	3	EFO_0005058
Disease	anterior thigh muscle fat infiltration measurement	ATXN2L HMCN2	1.64e-03	28	63	2	EFO_0020936
Disease	obesity	NRG1 ETV5 CMYA5 PRAG1	1.77e-03	241	63	4	EFO_0001073
Disease	Major Depressive Disorder	FOXD3 CMYA5 CRH TFCP2	1.83e-03	243	63	4	C1269683
Disease	physical activity measurement, body mass index	ATXN2L ETV5 FBXL17	1.88e-03	114	63	3	EFO_0004340, EFO_0008002
Disease	uric acid measurement	NRG1 PSORS1C1 INSRR ETV5 PLEKHA6 INS-IGF2	1.91e-03	610	63	6	EFO_0004761
Disease	neuroimaging measurement	MAGI1 ATXN2L ZNF474 ZHX2 TFCP2 MYO16 INS-IGF2 WNK2	1.92e-03	1069	63	8	EFO_0004346

Protein segments in the cluster

Peptide	Gene	Start	Entry
AQPPIVPRQTPPLQH	EP300	721	Q09472
GNQQPPVHPPRPERQ	CXorf49;	461	A8MYA2
PQQQHQPPPRPVHLQ	BRD4	986	O60885
QLPRVRPEHPQPQPT	AMER1	1086	Q5JTC6
RDPSQAPPVDVHQPP	ATG2A	206	Q2TAZ0
ILAPQPPPPQQHQER	ATXN2L	76	Q8WWM7
FHPEGQPQRLPQPPE	RBM33	1001	Q96EV2
PHHPNPPPENVQLVN	NRG1	296	Q02297
SPIPPVPHPRSVIQQ	PALMD	321	Q9NP74
EPHLQPRGQPAPQPL	IL17RA	651	Q96F46
PPPPTQLLPIHNQDA	KMT2C	1541	Q8NEZ4
PPQGLPNQLPVHPDL	KMT2C	2611	Q8NEZ4
PNQLPVHPDLEQVPP	KMT2C	2616	Q8NEZ4
VIPNHPPSNPEPARE	MAGI1	436	Q96QZ7
PPPPQLQAPRAHLSE	MAML3	651	Q96JK9
QQILHHAEPRVPPPP	MYO16	1816	Q9Y6X6
HVPPQIAGPREPPTQ	HMCN2	2261	Q8NDA2
PQPAVRHQGPEPLLE	FAM90A22	211	A8MWA6
EDHPQNPPEDPNQDP	L3MBTL1	146	Q9Y468
PQQQTFAVPRPPHQP	ETV5	186	P41161
ARPENPEIPAPQHLP	LMNTD2	546	Q8IXW0
QAPQHPQPLDFFQPP	CRH	36	P06850
HPDSQQPPQPLRDPH	ATXN7	401	O15265
RIPQPNQTLDPEPQH	DCP1B	211	Q8IZD4
RARQPPTPQPVQHPG	EVA1C	6	P58658
EQIPPHPPRDPQGQS	FRMPD1	1171	Q5SYB0
HREPPPETPDINQLP	FBXL17	311	Q9UF56
PPHPAPNPLTQLEEA	AXIN1	696	O15169
QVAVPQPPRLEPQEP	CMYA5	3701	Q8N3K9
NPARPLPTPPHLQAE	CEACAM19	261	Q7Z692
VQNLTEPPGPPVHPE	ITGA10	1016	O75578
QHPPPGQVLPPLEAQ	INSRR	691	P14616
QPQPEEEAQPPQAFP	ENAM	146	Q9NRM1
HIILRPNTQPPPAPA	FASN	401	P49327
PVVPASAPHPRPLQE	CACNA1H	1936	O95180
RHAQPPPIPVQNDPE	SCAF8	1221	Q9UPN6
EQPPQPPLDPQNLAR	CTU2	201	Q2VPK5
PQPPHQQPLTLPKEA	FOXD3	71	Q9UJU5
PAQPAPQPEPQQARE	INS-IGF2	166	F8WCM5
PQPEPQQAREPSPEV	INS-IGF2	171	F8WCM5
PFPRVEPSPQDQHQP	PLA2G4D	696	Q86XP0
PPSNEPATEHPEPQQ	MIA2	1396	Q96PC5
EPQPRPQDEPRAQQP	GDF6	66	Q6KF10
EPRQQPQPPPEEPAQ	RHOXF1	76	Q8NHV9
QEEAHTPEAPPPQPP	SH3D21	411	A4FU49
QAREPPEQLPQHRPG	LRRC56	346	Q8IYG6
QPPTQQQPPLPEREE	PRR3	11	P79522
PQPVHRPNPLLSPVE	SRCAP	2921	Q6ZRS2
PPAEVHRPARQPQQG	SSH1	546	Q8WYL5
QENHQAPVPPQPDDL	ACSL6	256	Q9UKU0
EAPPPPLQPETNDVH	RNF17	356	Q9BXT8
QQPPHNSLPKPEPEA	PLEKHA6	191	Q9Y2H5
PIQQPSISHQQPPPR	TRIM24	501	O15164
PPPQQSRPVLQAEPH	PHC2	361	Q8IXK0
EDLQHLPPQPLPPQL	TTBK1	606	Q5TCY1
VPPRSFVPPQPTNHQ	SPEM3	601	A0A1B0GUW6
ENRIPQPPPIAHPRT	RILPL1	331	Q5EBL4
NHQPEPPPPVTDNLL	TFCP2	311	Q12800
QQPPSRPPHLPVEER	RNF44	56	Q7L0R7
EEAARLQQPQPLPPP	PSORS1C1	106	Q9UIG5
SIHREAVPPPPPQNN	WIPF1	276	O43516
PPPHIPVQVVGTRQP	PHC1	521	P78364
EPQPPAHPREATQPE	PRAG1	396	Q86YV5
DPVPALPTHPPAQEQ	PRAG1	1071	Q86YV5
PHIAQVPEPPPKVAN	ZHX2	421	Q9Y6X8
VELHQPLPQKPQPLP	ZNF474	256	Q6S9Z5
RPEPLQPHLPEQAAP	WNK2	1001	Q9Y3S1
PPAQPLSENPPNHIL	SNRPA	196	P09012
HRPQAQPAPAQAPQP	KLF5	56	Q13887
LAANRPHQPPPPQQA	NACC1	211	Q96RE7
APQPQPQTPRHPQLA	NECAB3	16	Q96P71