Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	benzoate-CoA ligase activity	ACSM2A ACSM2B	7.46e-06	3	32	2	GO:0018858
GeneOntologyMolecularFunction	decanoate-CoA ligase activity	ACSM2A ACSM2B	1.49e-05	4	32	2	GO:0102391
GeneOntologyMolecularFunction	tRNA pseudouridine synthase activity	TRUB1 PUS7	6.92e-05	8	32	2	GO:0106029
GeneOntologyMolecularFunction	fatty-acyl-CoA synthase activity	ACSM2A ACSM2B	6.92e-05	8	32	2	GO:0004321
GeneOntologyMolecularFunction	medium-chain fatty acid-CoA ligase activity	ACSM2A ACSM2B	1.36e-04	11	32	2	GO:0031956
GeneOntologyMolecularFunction	S-methyltransferase activity	KMT2A ASMT	1.36e-04	11	32	2	GO:0008172
GeneOntologyMolecularFunction	pseudouridine synthase activity	TRUB1 PUS7	1.92e-04	13	32	2	GO:0009982
GeneOntologyMolecularFunction	vascular endothelial growth factor receptor binding	ANGPT1 ANGPT2	3.33e-04	17	32	2	GO:0005172
GeneOntologyMolecularFunction	C-acyltransferase activity	ACSM2A ACSM2B	5.13e-04	21	32	2	GO:0016408
GeneOntologyMolecularFunction	fatty acid ligase activity	ACSM2A ACSM2B	7.89e-04	26	32	2	GO:0015645
GeneOntologyMolecularFunction	CoA-ligase activity	ACSM2A ACSM2B	8.52e-04	27	32	2	GO:0016405
GeneOntologyMolecularFunction	intramolecular transferase activity	TRUB1 PUS7	9.83e-04	29	32	2	GO:0016866
GeneOntologyMolecularFunction	acid-thiol ligase activity	ACSM2A ACSM2B	1.12e-03	31	32	2	GO:0016878
GeneOntologyMolecularFunction	ligase activity, forming carbon-sulfur bonds	ACSM2A ACSM2B	1.96e-03	41	32	2	GO:0016877
GeneOntologyMolecularFunction	signaling receptor inhibitor activity	LYNX1 ANGPT2	2.46e-03	46	32	2	GO:0030547
GeneOntologyMolecularFunction	acyltransferase activity	HERC1 BCOR ACSM2A UBR4 ACSM2B	7.33e-03	775	32	5	GO:0016746
GeneOntologyBiologicalProcess	positive regulation of receptor internalization	DRD2 AP2M1 ANGPT1	1.96e-05	34	32	3	GO:0002092
GeneOntologyBiologicalProcess	Tie signaling pathway	ANGPT1 ANGPT2	2.33e-05	5	32	2	GO:0048014
GeneOntologyBiologicalProcess	mRNA pseudouridine synthesis	TRUB1 PUS7	8.34e-05	9	32	2	GO:1990481
GeneOntologyBiologicalProcess	positive regulation of receptor-mediated endocytosis	DRD2 AP2M1 ANGPT1	1.52e-04	67	32	3	GO:0048260
Domain	PsdUridine_synth_cat_dom	TRUB1 PUS7	2.19e-04	13	32	2	IPR020103
Domain	SEA	MUC16 MUC3A	2.55e-04	14	32	2	SM00200
Domain	AMP-bd_C	ACSM2A ACSM2B	3.81e-04	17	32	2	IPR025110
Domain	AMP-binding_C	ACSM2A ACSM2B	3.81e-04	17	32	2	PF13193
Domain	Fibrinogen_CS	ANGPT1 ANGPT2	4.78e-04	19	32	2	IPR020837
Domain	SEA	MUC16 MUC3A	7.04e-04	23	32	2	PS50024
Domain	SEA_dom	MUC16 MUC3A	7.04e-04	23	32	2	IPR000082
Domain	-	ANGPT1 ANGPT2	7.67e-04	24	32	2	4.10.530.10
Domain	Fibrinogen_a/b/g_C_2	ANGPT1 ANGPT2	7.67e-04	24	32	2	IPR014715
Domain	AMP-binding_CS	ACSM2A ACSM2B	9.01e-04	26	32	2	IPR020845
Domain	Fibrinogen_C	ANGPT1 ANGPT2	9.72e-04	27	32	2	PF00147
Domain	AMP_BINDING	ACSM2A ACSM2B	1.05e-03	28	32	2	PS00455
Domain	FBG	ANGPT1 ANGPT2	1.12e-03	29	32	2	SM00186
Domain	AMP-binding	ACSM2A ACSM2B	1.20e-03	30	32	2	PF00501
Domain	-	ANGPT1 ANGPT2	1.20e-03	30	32	2	3.90.215.10
Domain	Fibrinogen_a/b/g_C_1	ANGPT1 ANGPT2	1.20e-03	30	32	2	IPR014716
Domain	AMP-dep_Synth/Lig	ACSM2A ACSM2B	1.20e-03	30	32	2	IPR000873
Domain	Fibrinogen_a/b/g_C_dom	ANGPT1 ANGPT2	1.37e-03	32	32	2	IPR002181
Domain	FIBRINOGEN_C_2	ANGPT1 ANGPT2	1.37e-03	32	32	2	PS51406
Domain	FIBRINOGEN_C_1	ANGPT1 ANGPT2	1.37e-03	32	32	2	PS00514
Pathway	REACTOME_CONJUGATION_OF_SALICYLATE_WITH_GLYCINE	ACSM2A ACSM2B	4.15e-05	6	24	2	MM14693
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	5.80e-05	7	24	2	MM14598
Pathway	REACTOME_AMINO_ACID_CONJUGATION	ACSM2A ACSM2B	9.93e-05	9	24	2	M26968
Pathway	REACTOME_DEFECTIVE_GALNT3_CAUSES_HFTC	MUC16 MUC3A	3.29e-04	16	24	2	M27410
Pathway	REACTOME_DEFECTIVE_C1GALT1C1_CAUSES_TNPS	MUC16 MUC3A	3.72e-04	17	24	2	M27412
Pathway	REACTOME_TIE2_SIGNALING	ANGPT1 ANGPT2	3.72e-04	17	24	2	MM14836
Pathway	REACTOME_TIE2_SIGNALING	ANGPT1 ANGPT2	4.18e-04	18	24	2	M11932
Pathway	REACTOME_TERMINATION_OF_O_GLYCAN_BIOSYNTHESIS	MUC16 MUC3A	6.88e-04	23	24	2	M556
Pathway	REACTOME_DECTIN_2_FAMILY	MUC16 MUC3A	8.81e-04	26	24	2	M27483
Pubmed	Admission angiopoietin levels in children with septic shock.	ANGPT1 ANGPT2	8.73e-07	2	33	2	18092380
Pubmed	Comparative analyses of disease risk genes belonging to the acyl-CoA synthetase medium-chain (ACSM) family in human liver and cell lines.	ACSM2A ACSM2B	8.73e-07	2	33	2	19634011
Pubmed	Dynamic changes in serum angiopoietin-1, angiopoietin-2, and angiopoietin-2/angiopoietin-1 ratio in acute myocardial infarction patients treated with primary percutaneous coronary intervention.	ANGPT1 ANGPT2	8.73e-07	2	33	2	22642477
Pubmed	The L513S polymorphism in medium-chain acyl-CoA synthetase 2 (MACS2) is associated with risk factors of the metabolic syndrome in a Caucasian study population.	ACSM2A ACSM2B	8.73e-07	2	33	2	16521160
Pubmed	The angiopoietin 1/angiopoietin 2 balance as a prognostic marker in primary glioblastoma multiforme.	ANGPT1 ANGPT2	8.73e-07	2	33	2	18991494
Pubmed	Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.	ANGPT1 ANGPT2	8.73e-07	2	33	2	12361603
Pubmed	Angiopoietins and Tie-2 expression in angiogenesis and proliferation of human hepatocellular carcinoma.	ANGPT1 ANGPT2	8.73e-07	2	33	2	12717391
Pubmed	Imbalance of angiopoietin-1 and angiopoetin-2 in severe dengue and relationship with thrombocytopenia, endothelial activation, and vascular stability.	ANGPT1 ANGPT2	8.73e-07	2	33	2	22949515
Pubmed	Angiopoietins bind thrombomodulin and inhibit its function as a thrombin cofactor.	ANGPT1 ANGPT2	8.73e-07	2	33	2	29323190
Pubmed	Levels of angiopoietins 1 and 2 in induced sputum supernatant in patients with COPD.	ANGPT1 ANGPT2	8.73e-07	2	33	2	22483377
Pubmed	Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays.	ANGPT1 ANGPT2	8.73e-07	2	33	2	18664247
Pubmed	Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes.	ANGPT1 ANGPT2	8.73e-07	2	33	2	32399088
Pubmed	A high angiopoietin-2/angiopoietin-1 ratio is associated with a high risk of septic shock in patients with febrile neutropenia.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23915833
Pubmed	Differential regulation of angiopoietin 1 and angiopoietin 2 during dengue virus infection of human umbilical vein endothelial cells: implications for endothelial hyperpermeability.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23989887
Pubmed	Disruption of vascular endothelial homeostasis in systemic juvenile idiopathic arthritis-associated macrophage activation syndrome: The dynamic roles of angiopoietin-1 and -2.	ANGPT1 ANGPT2	8.73e-07	2	33	2	26908294
Pubmed	Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts.	ANGPT1 ANGPT2	8.73e-07	2	33	2	17273793
Pubmed	Preliminary observations on ANGPT1 and ANGPT2 polymorphisms in systemic sclerosis: ANGPT2 rs2442598 and rs3739390 are associated with disease susceptibility and diffuse disease subtype.	ANGPT1 ANGPT2	8.73e-07	2	33	2	34643357
Pubmed	Intrahepatic angiopoietin-2 correlates with chronic hepatitis C progression and is induced in hepatitis C virus replicon systems.	ANGPT1 ANGPT2	8.73e-07	2	33	2	28027429
Pubmed	Arterial stiffness in hypertensives in relation to expression of angiopoietin-1 and 2 genes in peripheral monocytes.	ANGPT1 ANGPT2	8.73e-07	2	33	2	20072144
Pubmed	Angiopoietins in haematopoietic stem cell mobilisation in patients with haematological malignancies.	ANGPT1 ANGPT2	8.73e-07	2	33	2	25369606
Pubmed	Deregulation of levels of angiopoietin-1 and angiopoietin-2 is associated with severe courses of hantavirus infection.	ANGPT1 ANGPT2	8.73e-07	2	33	2	28734140
Pubmed	[Expression of angiopoietin-1 and 2 in squamous cell carcinoma of the head and neck areas and normal mucosa].	ANGPT1 ANGPT2	8.73e-07	2	33	2	16229183
Pubmed	Regulation of angiopoietin expression by bacterial lipopolysaccharide.	ANGPT1 ANGPT2	8.73e-07	2	33	2	18310225
Pubmed	Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension.	ANGPT1 ANGPT2	8.73e-07	2	33	2	34326408
Pubmed	A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia.	ANGPT1 ANGPT2	8.73e-07	2	33	2	12612904
Pubmed	Common protective and diverse smooth muscle cell effects of AAV-mediated angiopoietin-1 and -2 expression in rat cardiac allograft vasculopathy.	ANGPT1 ANGPT2	8.73e-07	2	33	2	16690881
Pubmed	Analyses of the genetic diversity and protein expression variation of the acyl: CoA medium-chain ligases, ACSM2A and ACSM2B.	ACSM2A ACSM2B	8.73e-07	2	33	2	29948332
Pubmed	Analysis of angiogenic markers in oral squamous cell carcinoma-gene and protein expression.	ANGPT1 ANGPT2	8.73e-07	2	33	2	26044849
Pubmed	Increased levels of angiopoietins 1 and 2 in sputum supernatant in severe refractory asthma.	ANGPT1 ANGPT2	8.73e-07	2	33	2	22229541
Pubmed	Dysregulation of angiopoietins is associated with placental malaria and low birth weight.	ANGPT1 ANGPT2	8.73e-07	2	33	2	20208992
Pubmed	Angiopoietin-1 is an apoptosis survival factor for endothelial cells.	ANGPT1 ANGPT2	8.73e-07	2	33	2	10218485
Pubmed	Endothelial function in patients with metabolic syndrome and erectile dysfunction: a question of angiopoietin imbalance?	ANGPT1 ANGPT2	8.73e-07	2	33	2	23785018
Pubmed	Opposing effects of the angiopoietins on the thrombin-induced permeability of human pulmonary microvascular endothelial cells.	ANGPT1 ANGPT2	8.73e-07	2	33	2	21858121
Pubmed	Angiopoietin-2, Angiopoietin-1 and subclinical cardiovascular disease in Chronic Kidney Disease.	ANGPT1 ANGPT2	8.73e-07	2	33	2	27991547
Pubmed	Endovascular cooling and endothelial activation in hemorrhagic stroke patients.	ANGPT1 ANGPT2	8.73e-07	2	33	2	21380565
Pubmed	Dynamic contrast-enhanced magnetic resonance imaging parameters correlate with advanced revised-ISS and angiopoietin-1/angiopoietin-2 ratio in patients with multiple myeloma.	ANGPT1 ANGPT2	8.73e-07	2	33	2	28766001
Pubmed	Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension.	ANGPT1 ANGPT2	8.73e-07	2	33	2	18382887
Pubmed	Angiopoietin-1 and -2 exert antagonistic functions in tumor angiogenesis, yet both induce lymphangiogenesis.	ANGPT1 ANGPT2	8.73e-07	2	33	2	21778249
Pubmed	Angiopoietin balance in septic shock patients with acute lung injury: effect of direct hemoperfusion with polymyxin B-immobilized fiber.	ANGPT1 ANGPT2	8.73e-07	2	33	2	21884468
Pubmed	Angiopoietin-1 and -2 as markers for disease severity in hemolytic uremic syndrome induced by enterohemorrhagic Escherichia coli.	ANGPT1 ANGPT2	8.73e-07	2	33	2	26945868
Pubmed	Angiopoietin balance in septic shock patients treated by direct hemoperfusion with polymyxin b-immobilized fiber.	ANGPT1 ANGPT2	8.73e-07	2	33	2	19954476
Pubmed	Gingipains from the Periodontal Pathogen Porphyromonas gingivalis Play a Significant Role in Regulation of Angiopoietin 1 and Angiopoietin 2 in Human Aortic Smooth Muscle Cells.	ANGPT1 ANGPT2	8.73e-07	2	33	2	26283334
Pubmed	Ligand oligomerization state controls Tie2 receptor trafficking and angiopoietin-2-specific responses.	ANGPT1 ANGPT2	8.73e-07	2	33	2	22357955
Pubmed	Angiogenic axis angiopoietin-1 and angiopoietin-2/Tie-2 in non-small cell lung cancer: a bronchoalveolar lavage and serum study.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23835996
Pubmed	Angiopoietin 1 and angiopoietin 2 are associated with medial thickening of hepatic arterial branches in biliary atresia.	ANGPT1 ANGPT2	8.73e-07	2	33	2	24126820
Pubmed	Reduced Ang2 expression in aging endothelial cells.	ANGPT1 ANGPT2	8.73e-07	2	33	2	27137842
Pubmed	Angiopoietin-1 protects myocardial endothelial cell function blunted by angiopoietin-2 and high glucose condition.	ANGPT1 ANGPT2	8.73e-07	2	33	2	21113176
Pubmed	Angiopoietin-1 and angiopoietin-2 in diabetes mellitus: relationship to VEGF, glycaemic control, endothelial damage/dysfunction and atherosclerosis.	ANGPT1 ANGPT2	8.73e-07	2	33	2	15823283
Pubmed	Angiopoietins as serum biomarkers for lymphatic anomalies.	ANGPT1 ANGPT2	8.73e-07	2	33	2	27990590
Pubmed	TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code.	TRUB1 PUS7	8.73e-07	2	33	2	28073919
Pubmed	Evaluation of angiopoietin 1 and 2, vascular endothelial growth factor, and tumor necrosis factor alpha levels in asthmatic children.	ANGPT1 ANGPT2	8.73e-07	2	33	2	25584916
Pubmed	Ratio of angiopoietin-2 to angiopoietin-1 predicts mortality in acute lung injury induced by paraquat.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23302768
Pubmed	Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23.	ANGPT1 ANGPT2	8.73e-07	2	33	2	9545648
Pubmed	Angiopoietin-1 and -2 mRNA and protein expression in mouse preimplantation embryos and uteri suggests a role in angiogenesis during implantation.	ANGPT1 ANGPT2	8.73e-07	2	33	2	16836957
Pubmed	The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis.	ANGPT1 ANGPT2	8.73e-07	2	33	2	32059166
Pubmed	Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels.	ANGPT1 ANGPT2	8.73e-07	2	33	2	19815705
Pubmed	Angiopoietin-1/angiopoietin-2 ratio for prediction of preeclampsia.	ANGPT1 ANGPT2	8.73e-07	2	33	2	19478794
Pubmed	Angiopoietin-1 and angiopoietin-2 as serum biomarkers for ectopic pregnancy and missed abortion: a case-control study.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23099117
Pubmed	Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.	ANGPT1 ANGPT2	8.73e-07	2	33	2	15047628
Pubmed	The role of angiopoietins in the development of endothelial cells from cord blood CD34+ progenitors.	ANGPT1 ANGPT2	8.73e-07	2	33	2	15213103
Pubmed	Changes in circulating levels and ratios of angiopoietins during pregnancy but not during the menstrual cycle and controlled ovarian stimulation.	ANGPT1 ANGPT2	8.73e-07	2	33	2	19476937
Pubmed	Angiopoietin 1 and angiopoietin 2 in follicular fluid of women undergoing a long protocol.	ANGPT1 ANGPT2	8.73e-07	2	33	2	22000910
Pubmed	Pro-Angiogenic Actions of CMC-Derived Extracellular Vesicles Rely on Selective Packaging of Angiopoietin 1 and 2, but Not FGF-2 and VEGF.	ANGPT1 ANGPT2	8.73e-07	2	33	2	31102187
Pubmed	[Significance of a reversal expression of the angiopoietin-1 and 2 in oral squamous cell carcinoma].	ANGPT1 ANGPT2	8.73e-07	2	33	2	19567053
Pubmed	Expression of angiopoietin-2 is correlated with vascularization and tumor size in human colorectal adenocarcinoma.	ANGPT1 ANGPT2	8.73e-07	2	33	2	17785951
Pubmed	Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children.	ANGPT1 ANGPT2	8.73e-07	2	33	2	19300530
Pubmed	Selective functions of angiopoietins and vascular endothelial growth factor on blood vessels: the concept of "vascular domain".	ANGPT1 ANGPT2	8.73e-07	2	33	2	12858538
Pubmed	Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses.	ANGPT1 ANGPT2	8.73e-07	2	33	2	15498854
Pubmed	Angiopoietin-2/angiopoietin-1 as non-invasive biomarker of cirrhosis in chronic hepatitis C.	ANGPT1 ANGPT2	8.73e-07	2	33	2	27956798
Pubmed	Differential response of lymphatic, venous and arterial endothelial cells to angiopoietin-1 and angiopoietin-2.	ANGPT1 ANGPT2	8.73e-07	2	33	2	17341311
Pubmed	Endometrial angiopoietin expression and modulation by thrombin and steroid hormones: a mechanism for abnormal angiogenesis following long-term progestin-only contraception.	ANGPT1 ANGPT2	8.73e-07	2	33	2	15161644
Pubmed	A prospective study of endothelial activation biomarkers, including plasma angiopoietin-1 and angiopoietin-2, in Kenyan women initiating antiretroviral therapy.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23734875
Pubmed	Angiogenic response to major lung resection for non-small cell lung cancer with video-assisted thoracic surgical and open access.	ANGPT1 ANGPT2	8.73e-07	2	33	2	23024612
Pubmed	Angiopoietin-2 and angiopoietin-2/angiopoietin-1 ratio as indicators of potential severity of Plasmodium vivax malaria in patients with thrombocytopenia.	ANGPT1 ANGPT2	8.73e-07	2	33	2	25275496
Pubmed	Increased Angiopoietin-1 and -2 levels in human vitreous are associated with proliferative diabetic retinopathy.	ANGPT1 ANGPT2	8.73e-07	2	33	2	36662891
Pubmed	Vitreous levels of angiopoietin-1 and angiopoietin-2 in eyes with retinopathy of prematurity.	ANGPT1 ANGPT2	8.73e-07	2	33	2	21168819
Pubmed	Overexpression of angiopoietin-1 and angiopoietin-2 in hepatocellular carcinoma.	ANGPT1 ANGPT2	8.73e-07	2	33	2	15094228
Pubmed	Effect of HIV-1 Infection on Angiopoietin 1 and 2 Levels and Measures of Microvascular and Macrovascular Endothelial Dysfunction.	ANGPT1 ANGPT2	8.73e-07	2	33	2	34726064
Pubmed	Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity.	ANGPT1 ANGPT2	8.73e-07	2	33	2	10514510
Pubmed	Systemic Angiopoietin-1/2 Dysregulation in Pediatric Sepsis and Septic Shock.	ANGPT1 ANGPT2	8.73e-07	2	33	2	30745813
Pubmed	Angiopoietins and Tie2 in vascular inflammation.	ANGPT1 ANGPT2	2.62e-06	3	33	2	28582314
Pubmed	Oligomerization and multimerization are critical for angiopoietin-1 to bind and phosphorylate Tie2.	ANGPT1 ANGPT2	2.62e-06	3	33	2	15769741
Pubmed	Autocrine/paracrine role of the angiopoietin-1 and -2/Tie2 system in cell proliferation and chemotaxis of cultured fibroblastic synoviocytes in rheumatoid arthritis.	ANGPT1 ANGPT2	2.62e-06	3	33	2	14991531
Pubmed	Angiogenic factors are associated with development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.	ANGPT1 ANGPT2	2.62e-06	3	33	2	26489624
Pubmed	Angiopoietin-1 but not angiopoietin-2 induces IL-8 synthesis and release by human neutrophils.	ANGPT1 ANGPT2	2.62e-06	3	33	2	22015631
Pubmed	Human placental vascular development: vasculogenic and angiogenic (branching and nonbranching) transformation is regulated by vascular endothelial growth factor-A, angiopoietin-1, and angiopoietin-2.	ANGPT1 ANGPT2	2.62e-06	3	33	2	12213874
Pubmed	Serum levels of angiogenic factors and their prognostic relevance in bladder cancer.	ANGPT1 ANGPT2	2.62e-06	3	33	2	18807212
Pubmed	Placental mRNA expression of angiopoietins (Ang)-1, Ang-2 and their receptor Tie-2 is altered in pregnancies complicated by preeclampsia.	ANGPT1 ANGPT2	2.62e-06	3	33	2	25047691
Pubmed	Plasma concentrations of Ang-1, Ang-2 and Tie-2 in gastric cancer.	ANGPT1 ANGPT2	2.62e-06	3	33	2	22449617
Pubmed	Effect of hindlimb unweighting on expression of hypoxia-inducible factor-1alpha vascular endothelial growth factor, angiopoietin, and their receptors in mouse skeletal muscle.	ANGPT1 ANGPT2	2.62e-06	3	33	2	17705680
Pubmed	Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping.	ANGPT1 ANGPT2	2.62e-06	3	33	2	10343124
Pubmed	Imbalanced serum levels of Ang1, Ang2 and VEGF in systemic sclerosis: Integrated effects on microvascular reactivity.	ANGPT1 ANGPT2	2.62e-06	3	33	2	31075243
Pubmed	Dysregulation of the angiopoietin-Tie-2 axis in sepsis and ARDS.	ANGPT1 ANGPT2	2.62e-06	3	33	2	23652985
Pubmed	Tie-2 is overexpressed by monocytes in autoimmune thyroid disorders and participates in their recruitment to the thyroid gland.	ANGPT1 ANGPT2	2.62e-06	3	33	2	19351722
Pubmed	Expression of angiopoietin-1, angiopoietin-2, and Tie2 genes in normal ovary with corpus luteum and in ovarian cancer.	ANGPT1 ANGPT2	2.62e-06	3	33	2	12138242
Pubmed	Involvement of the ANGPTs/Tie-2 system in ovarian hyperstimulation syndrome (OHSS).	ANGPT1 ANGPT2	2.62e-06	3	33	2	23123737
Pubmed	Prognostic significance of TIE2-expressing monocytes in hilar cholangiocarcinoma.	ANGPT1 ANGPT2	2.62e-06	3	33	2	27111031
Pubmed	Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria.	ANGPT1 ANGPT2	2.62e-06	3	33	2	34856707
Pubmed	Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium.	ANGPT1 ANGPT2	2.62e-06	3	33	2	19223473
Pubmed	Plasma concentration of angiopoietin-1, angiopoietin-2 and Tie-2 in cervical cancer.	ANGPT1 ANGPT2	2.62e-06	3	33	2	20099495
Interaction	ACSM2A interactions	ACSM2A ACSM2B	1.37e-05	4	31	2	int:ACSM2A
Interaction	ACSM2B interactions	ACSM2A ACSM2B	1.37e-05	4	31	2	int:ACSM2B
Cytoband	16p12.3	ACSM2A ACSM2B	2.77e-04	34	33	2	16p12.3
Cytoband	11q23	KMT2A DRD2	3.11e-04	36	33	2	11q23
GeneFamily	CD molecules\|Mucins	MUC16 MUC3A	2.41e-04	21	20	2	648
GeneFamily	Fibrinogen C domain containing	ANGPT1 ANGPT2	3.43e-04	25	20	2	554
GeneFamily	Acyl-CoA synthetase family	ACSM2A ACSM2B	3.72e-04	26	20	2	40
Coexpression	PDGF_ERK_DN.V1_DN	BCL9 ATXN8OS BTG1 ASMT	3.19e-05	149	32	4	M2828
Coexpression	GALIE_TUMOR_ANGIOGENESIS	ANGPT1 ANGPT2	4.02e-05	8	32	2	M1294
Coexpression	GALIE_TUMOR_ANGIOGENESIS	ANGPT1 ANGPT2	4.02e-05	8	32	2	MM1123
Coexpression	GSE2706_UNSTIM_VS_2H_R848_DC_DN	UAP1 SLC25A25 BTG1 DUSP5	8.90e-05	194	32	4	M4692
Coexpression	GSE2124_CTRL_VS_LYMPHOTOXIN_BETA_TREATED_MLN_UP	KMT2A HERC1 BTG1 UBR4	9.44e-05	197	32	4	M6191
Coexpression	GSE15330_LYMPHOID_MULTIPOTENT_VS_MEGAKARYOCYTE_ERYTHROID_PROGENITOR_UP	KMT2A SCFD1 BTG1 UBR4	1.00e-04	200	32	4	M7031
ToppCell	Control-Epithelial_cells-Airway_goblet\|Control / group, cell type (main and fine annotations)	MUC16 CATSPERB MUC3A DUSP5	1.01e-05	184	33	4	d92a71441e4e19f8c301999d8186f8e48e3cd162
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_anti-infl-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RIPOR3 BTG1 HLA-DRB5 UBR4	1.37e-05	199	33	4	667b8b47a5b388506e3177b46747267fad8024f6
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RIPOR3 ANGPT2 NUP210L	5.37e-05	99	33	3	98c40a27432929434879c9e7283a14102f405f39
ToppCell	Frontal_cortex-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3-MURAL_Mural.Rgs5Acta2.Col3a1_(Mural.Rgs5Acta2.Col3a1)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	RIPOR3 ANGPT2 NUP210L	5.37e-05	99	33	3	d6bd8075dc7aba2034ea78b1389868282bc80a2d
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UAP1 DRD2 ANGPT1	1.41e-04	137	33	3	81cdb216e6c81acf9c2072f9d39e1a42612e1258
ToppCell	Globus_pallidus-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ANGPT1 ANGPT2 UBTFL1	1.60e-04	143	33	3	9bfb3674c8f011b9cf928b522777b8d54478db8d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MUC16 ACSM2A ACSM2B	1.95e-04	153	33	3	499670e716fc85ce76630fc813cec86f8419f2a1
ToppCell	normal_Lymph_Node-T/NK_cells-CD8+/CD4+_Mixed_Th\|normal_Lymph_Node / Location, Cell class and cell subclass	NUP210L BTG1 DUSP5	2.31e-04	162	33	3	12bd0b99aee13da60d0684a5e2a705824db1899c
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_C\|TCGA-Thymus / Sample_Type by Project: Shred V9	MUC16 CATSPERB DUSP5	2.35e-04	163	33	3	2dac87d15051151ccf193760ddd8b82534c3f922
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CATSPERB ANGPT2 DUSP5	2.39e-04	164	33	3	8f074940afdbda88a4b697a7ddc687e09a4b818b
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_medulla-lymphatic_endothelial_cell_of_renal_medulla\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CATSPERB ANGPT2 DUSP5	2.39e-04	164	33	3	a784f47f67a5eda84d58ad7d9400e3978edbb487
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-lymphatic_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CATSPERB ANGPT2 DUSP5	2.39e-04	164	33	3	1a1795969673232191425dde84ab24ee6a98143f
ToppCell	normal_Lymph_Node-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	NUP210L BTG1 DUSP5	2.48e-04	166	33	3	d638d356592325cded4a6cb549041cf2f8d3e62c
ToppCell	Endothelial-B-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	ANGPT2 ACSM2A ACSM2B	2.48e-04	166	33	3	c286987ea4e511195607c87ec4529c2c2ed2122e
ToppCell	facs\|World / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANGPT1 PAN3 DUSP5	2.71e-04	171	33	3	c9990bc041a632b2f7bbebbfe737772c423d7027
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 MUC3A DUSP5	2.85e-04	174	33	3	207aa0118633cbe9a65839bbb1bb3ba9f8118ad2
ToppCell	facs\|World / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PAN3 NUP210L DUSP5	2.90e-04	175	33	3	53e96956019f984decc1c81376ebc88fbf3c4d40
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	RIPOR3 ANGPT2 HLA-DRB5	2.95e-04	176	33	3	437cfc5e06416bb0fc76d1f9dc106f74e279e880
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AP2M1 C1orf198 ANGPT2	3.04e-04	178	33	3	e5e5f5b4a27e120a1076b1cb250fa25d0c336956
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	AP2M1 C1orf198 ANGPT2	3.04e-04	178	33	3	c661246269ce26c4fc62e12f86c5f90a2dcfdce0
ToppCell	3'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	UBTFL1 HLA-DRB5 DUSP5	3.04e-04	178	33	3	8184a2b9872f7ca12a9823535de485e841aeffb1
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 CATSPERB DUSP5	3.09e-04	179	33	3	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-Activated_DCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	BCOR HLA-DRB5 DUSP5	3.15e-04	180	33	3	aae85fb3c92a45614616a3ee3a1af5244cc299a7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RIPOR3 BCOR ACSM2A	3.20e-04	181	33	3	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	COVID-19-Heart-EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RIPOR3 ANGPT2 MUC3A	3.25e-04	182	33	3	e67f3234165199085c793915ebb1f9bbd845e933
ToppCell	5'-Adult-Appendix-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CATSPERB LYNX1 ANGPT2	3.25e-04	182	33	3	fd786c88826ad3d5cc5c3d80f8e392d6be1b5267
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ACSM2A ACSM2B	3.41e-04	185	33	3	9de1db2ce9e44956b1214daf6e1e161334679c88
ToppCell	3'-Child09-12-SmallIntestine-Endothelial-lymphatic_endothelial\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ACSM2A ACSM2B	3.41e-04	185	33	3	18f5d9438c76e37988a7d17aa2a080af6bedbfc4
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ACSM2A ACSM2B	3.46e-04	186	33	3	30dd4164c101006c8d95922d89652b82dbe4b5ea
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ACSM2A ACSM2B	3.46e-04	186	33	3	eeacf59a9e6bf1c9fd59b6b13d35e8abae228cf0
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 LYNX1 DUSP5	3.52e-04	187	33	3	71d99a1a95d3692a2891da49d4a243bae6e07fd0
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-Trm_Th1/Th17\|Lung / Manually curated celltypes from each tissue	KMT2A BTG1 DUSP5	3.63e-04	189	33	3	f43960506ed3e699e910ec7711c1113e2e9b80d1
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1orf198 ANGPT1 ANGPT2	3.63e-04	189	33	3	d0c7549be4f77520c23dddf4f94d0fcad0081e37
ToppCell	normal_Lung-Endothelial_cells-Lymphatic_ECs\|normal_Lung / Location, Cell class and cell subclass	ANGPT2 ACSM2A ACSM2B	3.68e-04	190	33	3	2185db6007404a2b22325f91460dd17635be9bba
ToppCell	(0)_Normal/No_Treatment-(1)_VE-Cad+_vascular_cells\|World / Stress and Cell class	NUP210L BTG1 DUSP5	3.68e-04	190	33	3	ff083168d609957d00888f31b3488d6d56c902b4
ToppCell	ILEUM-non-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ANGPT2 ACSM2A ACSM2B	3.68e-04	190	33	3	9ce301841ce9486701fa28eb2a9929e35d476878
ToppCell	pdx-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ACSM2A MUC3A ACSM2B	3.68e-04	190	33	3	b05db0de9b6ae01dd30074453f7de44f7397631e
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ACSM2A ACSM2B	3.74e-04	191	33	3	361b123c8289015206d5e706ab2c615d9a724179
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BTG1 HLA-DRB5 DUSP5	3.74e-04	191	33	3	7bad04f8afa949ea952c5c0d71eec43271ade680
ToppCell	3'-Pediatric_IBD-SmallIntestine-Endothelial-lymphatic_endothelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT2 ACSM2A ACSM2B	3.74e-04	191	33	3	011dc22c488369734749e839d65d52fe46b6a1a4
ToppCell	5'\|World / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 LYNX1 HLA-DRB5	3.74e-04	191	33	3	0e752756e9d1b444930522efc0fdca072d42535f
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4\|Lung / Manually curated celltypes from each tissue	KMT2A BTG1 DUSP5	3.80e-04	192	33	3	fd19cd0b5330448bef8debd753285adbc8b958a2
ToppCell	3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1orf198 ANGPT1 ANGPT2	3.80e-04	192	33	3	5995bae840c0b3f420288f557634d0ae9a12a6ae
ToppCell	renal_papilla_nuclei-Adult_normal_reference\|renal_papilla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	RIPOR3 ANGPT1 BTG1	3.80e-04	192	33	3	6c106b91e46eabbe686a52a65a9c94ad9cbe9390
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	CATSPERB RIPOR3 UAP1	3.80e-04	192	33	3	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	ILEUM-inflamed-(7)_Endothelial_cell-(7)_Lymphatics\|(7)_Endothelial_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ANGPT2 ACSM2A ACSM2B	3.80e-04	192	33	3	d43caf42ec744e895137f31ef65a990e250669d2
ToppCell	human_hepatoblastoma-Tumor_cells-T8\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	SLC25A25 ACSM2A ACSM2B	3.80e-04	192	33	3	e785135262f4c9cc66c403bf362bb34643b212c5
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	PAN3 ACSM2A ACSM2B	3.80e-04	192	33	3	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	IIH\|World / Condition, Cell_class and T cell subcluster	ATXN8OS NUP210L HLA-DRB5	3.86e-04	193	33	3	a9af5ccff108d51939ead130583f5b950d3092ed
ToppCell	3'-GW_trimst-1-LargeIntestine-Mesenchymal-Pericytes\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1orf198 ANGPT1 ANGPT2	3.86e-04	193	33	3	47d189bac0ef4df2f5c6dd987e46aca85bd7e2af
ToppCell	wk_15-18\|World / Celltypes from embryonic and fetal-stage human lung	BTG1 HLA-DRB5 DUSP5	3.86e-04	193	33	3	a28ff1e80e3e741739abe869df5fbd41352a1ea0
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_mature_DC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RIPOR3 BTG1 DUSP5	3.86e-04	193	33	3	d9be4d1de863fffc2240d6fd1a2f8dfb2d2bc916
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CATSPERB RIPOR3 UAP1	3.86e-04	193	33	3	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	C1orf198 ANGPT1 ANGPT2	3.86e-04	193	33	3	800b0f5705fefcd3608e37801afae8a94474723e
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYNX1 BTG1 DUSP5	3.92e-04	194	33	3	ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LYNX1 BTG1 DUSP5	3.92e-04	194	33	3	fdd59b1e036b2d6d8877e1a920a0e56a91a2a882
ToppCell	ILEUM-non-inflamed-(1)_T_cell-(1)_Cytotoxic_CD8_Trm\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	BTG1 HLA-DRB5 DUSP5	3.92e-04	194	33	3	094e8dfe640c7cca410b85f93063ea0bd7e861cf
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACSM2A UBR4 ACSM2B	3.92e-04	194	33	3	70185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCell	E18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANGPT1 ANGPT2 DUSP5	3.97e-04	195	33	3	6e875c83f838241b5fcaf4a3249b1408d74521dc
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM\|Liver / Manually curated celltypes from each tissue	KMT2A BTG1 DUSP5	3.97e-04	195	33	3	972b09697b7b66fb8a27dfc0c0b05a844121f055
ToppCell	distal-2-Endothelial-Lymphatic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANGPT2 ACSM2A ACSM2B	3.97e-04	195	33	3	8e0f67a67af3bc0b16f48a621f74540f136383b7
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ANGPT1 ANGPT2 BTG1	3.97e-04	195	33	3	815ac5dacd382b11abb32011ed1c0635b0ddc779
ToppCell	metastatic_Brain-Myeloid_cells-CD163+CD14+_DCs\|Myeloid_cells / Location, Cell class and cell subclass	BTG1 HLA-DRB5 DUSP5	3.97e-04	195	33	3	79fd13a7dd9f07f86bcab280c0be1899a692fab2
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo\|Liver / Manually curated celltypes from each tissue	KMT2A BTG1 DUSP5	3.97e-04	195	33	3	c29c4ae95a756e3ced0f0747bbfe343590e5b8ab
ToppCell	distal-Endothelial-Lymphatic-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANGPT2 ACSM2A ACSM2B	3.97e-04	195	33	3	f45c1349932ee7eb419cced8a4fdedae3610953f
ToppCell	distal-Endothelial-Lymphatic\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	ANGPT2 ACSM2A ACSM2B	4.03e-04	196	33	3	3e8a20e1d163dcbd3bbd99fe179d54af02298af0
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC16 BCOR SLC25A25	4.03e-04	196	33	3	547901c7a665770eff78eede69b8625b416c8186
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_secretory\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 CATSPERB SLC25A25	4.03e-04	196	33	3	b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 LYNX1 DUSP5	4.03e-04	196	33	3	7a4d502550e9e37dc42f2ff1be3c896afe365d7f
ToppCell	3'-Child09-12\|3' / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MUC3A BTG1 HLA-DRB5	4.03e-04	196	33	3	1bcc4ffff51cdb6211824686c2422c43b09e24b2
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 LYNX1 DUSP5	4.03e-04	196	33	3	a52879a4c822c5e4be569f01f845a795e00c5f4b
ToppCell	Mild/Remission\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	PAN3 BTG1 HLA-DRB5	4.03e-04	196	33	3	71603a3b7df40eb3f267345f55e44a812fea7926
ToppCell	10x5'-Liver-Lymphocytic_T_CD8-Trm/em_CD8\|Liver / Manually curated celltypes from each tissue	KMT2A BTG1 DUSP5	4.03e-04	196	33	3	91c85ea202508185142ef67af6d27d0932567ca0
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	C1orf198 ANGPT1 ANGPT2	4.03e-04	196	33	3	88dc4e3efd7ea07617ecde142ec47cc57608f81b
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MUC16 CATSPERB SLC25A25	4.03e-04	196	33	3	c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 LYNX1 DUSP5	4.03e-04	196	33	3	60ea673ed887fe3890c5cf4ff4165384b76d7361
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Epithelial-Epithelial,_Airway-secretory_cell-Epi-Secretory\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MUC16 BCOR SLC25A25	4.03e-04	196	33	3	6e08d7ba67da161c2dca1a17c440ffb9d9b5bc3b
ToppCell	Bronchial_Biopsy-Epithelial-Club\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	MUC16 LYNX1 HLA-DRB5	4.09e-04	197	33	3	3f5dfa892a1f631b96eeb6f4cfc284aee51d1ce6
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BTG1 HLA-DRB5 DUSP5	4.09e-04	197	33	3	2a140c61e81aa18de2c9c1c443e314d6f09cdc18
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BTG1 HLA-DRB5 DUSP5	4.09e-04	197	33	3	fa3fe934bd5fd8c6520a9c46357f9e441c794aba
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.4\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MUC16 SLC25A25 DUSP5	4.09e-04	197	33	3	d83c61d2b5742e463122e1a98c7197a5b5b3d41b
ToppCell	3'-Parenchyma_lung-Immune_Myeloid-Dendritic-dendritic_cell-Migratory_DCs-Migratory_DCs_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BTG1 HLA-DRB5 DUSP5	4.09e-04	197	33	3	32eb4437cc608b8369e376446d639497ecfdd17a
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC2-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BTG1 HLA-DRB5 DUSP5	4.16e-04	198	33	3	c58e2d3a21fcca9f1accccc5303ca4222b6c8432
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-DC2\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BTG1 HLA-DRB5 DUSP5	4.16e-04	198	33	3	f4ff9520598ebc52b3a1f31eee766957983e16b4
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_MHC-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	BTG1 HLA-DRB5 DUSP5	4.16e-04	198	33	3	455d55cfdeb8b6b13c289b53e1a5184a574e2e35
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD8-positive,_alpha-beta_memory_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KMT2A BTG1 DUSP5	4.22e-04	199	33	3	69793ef363618030e4546877b3095c587617909f
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|Fibroblasts / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	ANGPT1 HLA-DRB5 DUSP5	4.22e-04	199	33	3	fcbb3a9c0f4c5b4c1f09db24b9f50cc1166fa43b
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ACSM2A UBR4 ACSM2B	4.28e-04	200	33	3	105564ee05bd11685b5747ee32d5350cf3c2e2e1
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	KMT2A BTG1 DUSP5	4.28e-04	200	33	3	51877bb53d64a2e3d3138d487e96cb5cda7e826f
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANGPT2 ACSM2A ACSM2B	4.28e-04	200	33	3	35f6c7f2469d12748c27f2a5d4a161ef839b4a07
ToppCell	Tracheal-10x3prime_v2-Endothelial-Endothelia_lymphatic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	ANGPT2 ACSM2A ACSM2B	4.28e-04	200	33	3	b515b2ab0c3f5928dd67f2f227fc932451c272bb
Disease	X-21319 measurement	ACSM2A ACSM2B	1.14e-06	2	32	2	EFO_0800807
Disease	X-11478 measurement	ACSM2A ACSM2B	3.42e-06	3	32	2	EFO_0021242
Disease	3-hydroxyhexanoate measurement	ACSM2A ACSM2B	1.14e-05	5	32	2	EFO_0800378
Disease	indoleacetoylcarnitine measurement	ACSM2A ACSM2B	1.70e-05	6	32	2	EFO_0800106
Disease	non-alcoholic fatty liver disease	ACSM2A CWF19L1 HLA-DRB5 ACSM2B	4.40e-05	182	32	4	EFO_0003095
Disease	endometrial adenocarcinoma (is_marker_for)	ANGPT1 ANGPT2	6.23e-05	11	32	2	DOID:2870 (is_marker_for)
Disease	hepcidin:transferrin saturation ratio	MUC16 PAN3	1.19e-04	15	32	2	EFO_0007902
Disease	gastric ulcer (biomarker_via_orthology)	ANGPT1 ANGPT2	2.36e-04	21	32	2	DOID:10808 (biomarker_via_orthology)
Disease	nephrosis (biomarker_via_orthology)	ANGPT1 ANGPT2	2.60e-04	22	32	2	DOID:2527 (biomarker_via_orthology)
Disease	Antiglaucoma preparations and miotics use measurement	KMT2A ANGPT1	3.64e-04	26	32	2	EFO_0009944
Disease	cerebral white matter volume change measurement, age at assessment	KMT2A ANGPT1	4.23e-04	28	32	2	EFO_0008007, EFO_0021499

Protein segments in the cluster

Peptide	Gene	Start	Entry
MVPTLKSSCSYLRSM	CATSPERB	821	Q9H7T0
ILKTLSSYPIKSMMG	ACSM2A	296	Q08AH3
GYSLKATTMMIRPAD	ANGPT2	481	O15123
GPSYSLRSTTMMIRP	ANGPT1	481	Q15389
TVSPTSQCSMLKYMG	ASMT	96	P46597
PTLATYSGRTIMKMT	BCOR	1556	Q6W2J9
GMITRLFTSPIMTKS	MUC16	5546	Q8WXI7
LRVTSLFTPVMMKTT	MUC16	8881	Q8WXI7
YMAKLTVTLMVLSSP	HLA-DRB5	11	Q30154
TYSSMATTPSMTKIL	ATXN8OS	176	P0DMR3
ATTPSMTKILEGCMY	ATXN8OS	181	P0DMR3
VYTLPMVRSIGKTMV	HERC1	4451	Q15751
YSFSPKDVSSLRMML	CWF19L1	126	Q69YN2
TYFSSLSPMARKIMQ	C1orf198	31	Q9H425
ISGSLPMMTDLTSVY	MUC3A	1586	Q02505
VSGRVVMKSYLSGMP	AP2M1	196	Q96CW1
VETKYPLMQRMTNSS	PAN3	176	Q58A45
SRMSKFAMPSSTPLY	BCL9	1011	O00512
CMTTRTYYTPTRMKV	LYNX1	46	P0DP58
KLRIMSPMRTGNTYS	KMT2A	2206	Q03164
MPNGKTRTSLKTMSR	DRD2	346	P14416
GISRSPTICMAYLMK	DUSP5	266	Q16690
TRLITATKMPVYVMG	NUP210L	1181	Q5VU65
KGRVATVMYTVVTPM	OR1L4	271	Q8NGR5
NTQPTAYTSIMGSMK	LMBRD2	506	Q68DH5
PSTYATMAIREVLKM	PUS7	631	Q96PZ0
GRTSPSKNYNMMTVS	BTG1	156	P62324
ILKTLSSYPIKSMMG	ACSM2B	296	Q68CK6
SSIYPMEVLKTRMAL	SLC25A25	296	Q6KCM7
MYPGMRSQELTKILS	UBTFL1	121	P0CB47
RSRMPAKSSKMYGTL	RIPOR3	46	Q96MK2
STTTKPMGLLSRVMN	SCFD1	511	Q8WVM8
PWYIMTSGRTMESTK	UAP1	161	Q16222
TKMLTSMLSGSKRYT	TRUB1	136	Q8WWH5
ALVKRTPSSGMSSTM	UBR4	1726	Q5T4S7