Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessembryonic epithelial tube formation

DVL2 CDK20 FZD1 IRX1 CECR2

3.12e-06159305GO:0001838
GeneOntologyBiologicalProcessepithelial tube formation

DVL2 CDK20 FZD1 IRX1 CECR2

4.71e-06173305GO:0072175
GeneOntologyBiologicalProcesstube formation

DVL2 CDK20 FZD1 IRX1 CECR2

6.88e-06187305GO:0035148
GeneOntologyBiologicalProcessmorphogenesis of embryonic epithelium

DVL2 CDK20 FZD1 IRX1 CECR2

7.44e-06190305GO:0016331
GeneOntologyBiologicalProcessneural tube closure

DVL2 CDK20 FZD1 CECR2

2.10e-05113304GO:0001843
GeneOntologyBiologicalProcesstube closure

DVL2 CDK20 FZD1 CECR2

2.17e-05114304GO:0060606
GeneOntologyBiologicalProcessprimary neural tube formation

DVL2 CDK20 FZD1 CECR2

2.66e-05120304GO:0014020
GeneOntologyBiologicalProcessepithelial tube morphogenesis

DVL2 CDK20 FZD1 IRX1 LZTS2 CECR2

2.73e-05421306GO:0060562
GeneOntologyBiologicalProcessneural tube formation

DVL2 CDK20 FZD1 CECR2

4.09e-05134304GO:0001841
GeneOntologyBiologicalProcessneural tube development

DVL2 CDK20 FZD1 CECR2

2.00e-04202304GO:0021915
GeneOntologyBiologicalProcessregulation of establishment of planar polarity involved in neural tube closure

DVL2 FZD1

2.12e-0415302GO:0090178
GeneOntologyBiologicalProcessmorphogenesis of an epithelium

DVL2 CDK20 FZD1 IRX1 LZTS2 CECR2

2.29e-04619306GO:0002009
GeneOntologyBiologicalProcessestablishment of planar polarity involved in neural tube closure

DVL2 FZD1

2.42e-0416302GO:0090177
GeneOntologyBiologicalProcessestablishment of planar polarity of embryonic epithelium

DVL2 FZD1

3.08e-0418302GO:0042249
GeneOntologyBiologicalProcessregulation of establishment of planar polarity

DVL2 FZD1

3.44e-0419302GO:0090175
GeneOntologyBiologicalProcesssegment specification

DVL2 IRX1

4.64e-0422302GO:0007379
GeneOntologyBiologicalProcessembryonic morphogenesis

DVL2 CDK20 FZD1 COL5A2 IRX1 CECR2

4.88e-04713306GO:0048598
GeneOntologyBiologicalProcesstissue morphogenesis

DVL2 CDK20 FZD1 IRX1 LZTS2 CECR2

6.37e-04750306GO:0048729
GeneOntologyBiologicalProcessembryo development

DVL2 CDK20 FZD1 COL5A2 KMT2D IRX1 TRIP6 CECR2

7.98e-041437308GO:0009790
GeneOntologyBiologicalProcesstube morphogenesis

DVL2 CDK20 FZD1 IRX1 LZTS2 CECR2 ADGRB1

9.49e-041125307GO:0035239
HumanPhenoAbnormality of dental structure

MPLKIP COL5A2 KMT2D IQSEC2 SP7

3.56e-0536875HP:0011061
HumanPhenoAbnormal curvature of the vertebral column

MPLKIP COL5A2 KMT2D ATN1 IQSEC2 SCAF4 SP7

4.44e-05121977HP:0010674
HumanPhenoAbnormal joint physiology

MPLKIP COL5A2 KMT2D ATN1 IQSEC2 SCAF4 SP7

9.46e-05135877HP:0034430
HumanPhenoAbnormality of joint mobility

MPLKIP COL5A2 KMT2D ATN1 IQSEC2 SCAF4 SP7

9.46e-05135877HP:0011729
MousePhenoimpaired spatial learning

KMT2D PRRT1 IQSEC2 ADGRB1

1.91e-0591254MP:0012307
MousePhenoimpaired learning

KMT2D PRRT1 IQSEC2 ADGRB1

1.22e-04146254MP:0012315
MousePhenoabnormal response to new environment

FZD1 TTBK1 PRRT1 ATN1 CECR2 IQSEC2 ADGRB1

1.48e-04687257MP:0001413
MousePhenodecreased brain ependyma motile cilium number

CWH43 TRIP6

1.67e-0411252MP:0030966
MousePhenoabnormal learning/memory/conditioning

FZD1 CACNB3 KMT2D TTBK1 PRRT1 ATN1 CECR2 IQSEC2 ADGRB1

1.81e-041239259MP:0002063
MousePhenoabnormal cognition

FZD1 CACNB3 KMT2D TTBK1 PRRT1 ATN1 CECR2 IQSEC2 ADGRB1

1.89e-041246259MP:0014114
MousePhenoabnormal response to novelty

FZD1 TTBK1 PRRT1 ATN1 CECR2 IQSEC2 ADGRB1

3.43e-04787257MP:0003107
MousePhenoabnormal object recognition memory

CACNB3 KMT2D PRRT1

5.36e-0490253MP:0001458
DomainRNA_pol_II-bd

CHERP SCAF4

5.21e-057302IPR006903
DomainCTD_bind

CHERP SCAF4

5.21e-057302PF04818
DomainRPR

CHERP SCAF4

6.94e-058302SM00582
DomainCID_dom

CHERP SCAF4

6.94e-058302IPR006569
DomainCID

CHERP SCAF4

6.94e-058302PS51391
Domain-

CHERP SCAF4

7.91e-04263021.25.40.90
DomainENTH_VHS

CHERP SCAF4

9.86e-0429302IPR008942
DomainGPCR_2-like

FZD1 ADGRB1

4.17e-0360302IPR017981
DomainGPCR_2_secretin-like

FZD1 ADGRB1

4.17e-0360302IPR000832
DomainG_PROTEIN_RECEP_F2_4

FZD1 ADGRB1

4.30e-0361302PS50261
DomainPHD

DIDO1 KMT2D

6.44e-0375302PF00628
DomainZnf_PHD-finger

DIDO1 KMT2D

7.12e-0379302IPR019787
DomainPHD

DIDO1 KMT2D

8.96e-0389302SM00249
DomainZnf_PHD

DIDO1 KMT2D

9.35e-0391302IPR001965
DomainZF_PHD_2

DIDO1 KMT2D

1.02e-0295302PS50016
DomainZF_PHD_1

DIDO1 KMT2D

1.04e-0296302PS01359
PathwayKEGG_MEDICUS_REFERENCE_WNT5A_ROR_SIGNALING_PATHWAY

DVL2 FZD1

2.04e-0416192M47823
PathwayWP_REGULATION_OF_WNT_BCATENIN_SIGNALING_BY_SMALL_MOLECULE_COMPOUNDS

DVL2 FZD1

2.31e-0417192M39525
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL2 FZD1

7.82e-0431192M27400
PathwayREACTOME_DISASSEMBLY_OF_THE_DESTRUCTION_COMPLEX_AND_RECRUITMENT_OF_AXIN_TO_THE_MEMBRANE

DVL2 FZD1

7.82e-0431192MM15154
PathwayWP_TYPE_I_COLLAGEN_SYNTHESIS_IN_THE_CONTEXT_OF_OSTEOGENESIS_IMPERFECTA

FZD1 SP7

8.86e-0433192M39870
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL2 FZD1

1.06e-0336192M39699
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

DVL2 FZD1 KMT2D

1.17e-03158193MM14791
PathwayREACTOME_NCAM1_INTERACTIONS

COL5A2 CACNB3

1.43e-0342192M7169
PathwayWP_WNT_SIGNALING_IN_KIDNEY_DISEASE

DVL2 FZD1

1.57e-0344192MM15878
PathwayKEGG_MEDICUS_VARIANT_LRP6_OVEREXPRESSION_TO_WNT_SIGNALING_PATHWAY

DVL2 FZD1

1.65e-0345192M47412
PathwayKEGG_MEDICUS_REFERENCE_WNT_SIGNALING_PATHWAY

DVL2 FZD1

1.72e-0346192M47409
Pubmed

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

DVL2 DIDO1 LZTS2 ATN1 SCAF4

1.44e-0622031524550385
Pubmed

Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.

KMT2D CHERP

1.15e-0563128896557
Pubmed

Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.

DVL2 FZD1

2.15e-05831219388021
Pubmed

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.

DVL2 FZD1

3.44e-051031215143170
Pubmed

Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.

FZD1 CECR2

5.96e-051331221246654
Pubmed

A mutation in the tuft mouse disrupts TET1 activity and alters the expression of genes that are crucial for neural tube closure.

DVL2 CECR2

5.96e-051331226989192
Pubmed

The KMT2D Kabuki syndrome histone methylase controls neural crest cell differentiation and facial morphology.

KMT2D SP7

6.95e-051431232541010
Pubmed

Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor.

CHERP LZTS2 TRIP6

7.63e-059231320368287
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

KMT2D CHERP ATN1 GSE1

9.21e-0526831433640491
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

DIDO1 KMT2D LZTS2 TRIP6 SCAF4

1.16e-0454931538280479
Pubmed

Human transcription factor protein interaction networks.

DIDO1 KMT2D ATN1 GSE1 TRIP6 SCAF4 SP7

2.15e-04142931735140242
Pubmed

The protein interaction landscape of the human CMGC kinase group.

CDK20 DIDO1 FAM124A CHERP LZTS2

3.47e-0469531523602568
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

DVL2 LZTS2 ATN1 GSE1 TRIP6 CECR2

3.98e-04111631631753913
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

DIDO1 KMT2D ATN1 GSE1 SCAF4

5.67e-0477431515302935
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

KMT2D LZTS2 TRIP6

5.87e-0418431332908313
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

KMT2D ATN1 GSE1 TRIP6

6.99e-0445731432344865
Pubmed

Cleft lip and cleft palate in Esrp1 knockout mice is associated with alterations in epithelial-mesenchymal crosstalk.

DVL2 FZD1

8.11e-044731232253237
Pubmed

Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.

DVL2 FZD1

8.11e-044731233141892
Pubmed

Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.

DVL2 FZD1

8.11e-044731218351675
Pubmed

An inter-species protein-protein interaction network across vast evolutionary distance.

DVL2 FAM124A LZTS2 TRIP6

8.59e-0448331427107014
InteractionTLE3 interactions

KMT2D CHERP ATN1 GSE1 CECR2 SCAF4 SP7

1.33e-06376317int:TLE3
InteractionRUNX1T1 interactions

DVL2 LZTS2 ATN1 GSE1

4.15e-05127314int:RUNX1T1
InteractionTLE5 interactions

DVL2 FAM124A LZTS2 ATN1 TRIP6 SP7

5.04e-05443316int:TLE5
InteractionMAGI2 interactions

TTBK1 ATN1 ADGRB1

5.44e-0548313int:MAGI2
InteractionPYGO2 interactions

KMT2D TRIP6 SP7

5.44e-0548313int:PYGO2
InteractionSAXO1 interactions

FAM124A CHERP TRIP6

6.15e-0550313int:SAXO1
InteractionSP7 interactions

KMT2D ATN1 GSE1 SCAF4 SP7

9.31e-05304315int:SP7
InteractionGATA1 interactions

KMT2D LZTS2 GSE1 TRIP6

1.32e-04171314int:GATA1
InteractionALG13 interactions

KMT2D LZTS2 ATN1 GSE1

1.71e-04183314int:ALG13
InteractionWT1-AS interactions

LZTS2 TRIP6

1.77e-0413312int:WT1-AS
InteractionATN1 interactions

DVL2 ATN1 TRIP6 SP7

1.86e-04187314int:ATN1
InteractionFAM124B interactions

LZTS2 TRIP6 SP7

1.91e-0473313int:FAM124B
GeneFamilyPHD finger proteins

DIDO1 KMT2D

5.31e-039022288
ComputationalGenes in the cancer module 397.

DVL2 CACNB3 TRIP6

5.74e-04121153MODULE_397
DiseaseAbruptio Placentae

FAM124A IRX1

6.12e-0512292EFO_1001754
Diseasestomach cancer (is_marker_for)

KMT2D GSE1 ADGRB1

3.64e-04142293DOID:10534 (is_marker_for)
Diseasebreast carcinoma (is_marker_for)

FZD1 KMT2D

1.92e-0366292DOID:3459 (is_marker_for)
Diseasesusceptibility to strep throat measurement

MPLKIP PRRT1

2.54e-0376292EFO_0008408
DiseaseSquamous cell carcinoma of esophagus

DIDO1 KMT2D

3.94e-0395292C0279626
Diseasetestosterone measurement

TTBK1 IRX1 PRRT1 CECR2 IQSEC2

7.47e-031275295EFO_0004908

Protein segments in the cluster

PeptideGeneStartEntry
LGGPAPKAHPGPPHI

CDK20

306

Q8IZL9
HHPAPGPGLLGPPSA

CACNB3

361

P54284
PQHDGLRPRAGPPGP

ADGRB1

151

O14514
GGRDPPQHFGGPPPL

GSE1

556

Q14687
HGVPGPGLDPFPRHG

ATN1

961

P54259
PGPPGLHPFPFHPSL

ATN1

981

P54259
PGFIPPRHGGAPARP

CECR2

751

Q9BXF3
PNLRAHPGLHPYGPP

DVL2

656

O14641
PRPPSPRDGYGSPHH

MPLKIP

36

Q8TAP9
RPCPGGPAPPRHHGP

LZTS2

36

Q9BRK4
GPAPPRHHGPPGPTF

LZTS2

41

Q9BRK4
APHHGPPRFGLGPAP

NUDT19

81

A8MXV4
GPPGRAPIPHRHYPA

IQSEC2

636

Q5JU85
PHPGPIRTGLPPGHQ

FAM124A

326

Q86V42
CPHLQAGGGAPPHPP

FZD1

581

Q9UP38
YQRHHLPPPGPPGED

DUSP11

321

O75319
GPQHPDFGPPPHGFN

CHERP

606

Q8IWX8
DFGPPPHGFNGQPPH

CHERP

611

Q8IWX8
LFHGPPPAPAGGLPA

C2CD4D

106

B7Z1M9
RGPPPGHFVGPRGPH

DIDO1

1916

Q9BTC0
PGHPSHPGPDGLSRP

COL5A2

176

P05997
LPRPPHHAPPGPAAG

PRRT1

81

Q99946
KGPFPPHGPFVRPGG

SCAF4

906

O95104
GHPHPGPDPNPFGGA

CWH43

226

Q9H720
KASPPPPAGHPGAHG

IRX1

331

P78414
FLPGPKPGAPFPNGH

SLC45A3

431

Q96JT2
GHLGHFPGPEPLAFP

PRR22

216

Q8IZ63
ASGPLPGPHFPLPGR

TRIP6

191

Q15654
GLGPSPHLVPHPGGP

TTBK1

381

Q5TCY1
PGSPGHHPCAGPPGL

ZC3H6

496

P61129
GPRAHLPFVGPGPPR

TTC24

526

A2A3L6
KHQRTHGEPGPGPPP

SP7

371

Q8TDD2
TPRHPPPPAAGFGVH

URB1-AS1

6

Q96HZ7
LPPPHGINSHFGPGP

KMT2D

2556

O14686