Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionubiquitin-protein transferase activity

RNF8 UBE4A FBXO10 TRIM51 UBE4B BIRC6 MED8

8.34e-05473457GO:0004842
GeneOntologyMolecularFunctionubiquitin-like protein transferase activity

RNF8 UBE4A FBXO10 TRIM51 UBE4B BIRC6 MED8

1.36e-04512457GO:0019787
GeneOntologyMolecularFunctionaminoacyltransferase activity

RNF8 UBE4A FBXO10 TRIM51 UBE4B BIRC6 MED8

1.73e-04532457GO:0016755
GeneOntologyMolecularFunctionacyltransferase activity

RNF8 UBE4A FBXO10 TRIM51 BRCA2 UBE4B BIRC6 MED8

2.99e-04775458GO:0016746
GeneOntologyMolecularFunctionubiquitin-ubiquitin ligase activity

UBE4A UBE4B

4.44e-0414452GO:0034450
GeneOntologyCellularComponentubiquitin ligase complex

RNF8 UBE4A FBXO10 BRCA2 UBE4B MED8

1.02e-04352456GO:0000151
DomainUfd2P_core

UBE4A UBE4B

5.93e-062462PF10408
DomainUb_conjug_fac_E4_core

UBE4A UBE4B

5.93e-062462IPR019474
DomainU_BOX

UBE4A UBE4B

1.24e-047462PS51698
DomainUbox

UBE4A UBE4B

1.65e-048462SM00504
DomainU-box

UBE4A UBE4B

1.65e-048462PF04564
DomainUbox_domain

UBE4A UBE4B

2.64e-0410462IPR003613
Domain-

RANBP17 RIC8B HEATR5B LRRK2

2.14e-032224641.25.10.10
DomainARM-like

RANBP17 RIC8B HEATR5B LRRK2

4.33e-03270464IPR011989
DomainARM-type_fold

RANBP17 RIC8B HEATR5B LRRK2

9.55e-03339464IPR016024
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

PYGL NRIP1 TLN2 ASAP2 SZT2 CCDC62 MED8 LRRK2

3.07e-1020846833230847
Pubmed

The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.

RNF8 UBE4A BRCA2

6.14e-071346329499138
Pubmed

A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly.

UBE4A UBE4B

1.71e-06246210089879
Pubmed

The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression.

NRIP1 NR1H2

5.13e-06346239125645
Pubmed

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.

LRRK2 SEC16A

1.03e-05446225201882
Pubmed

Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.

NRIP1 NR1H2

1.03e-05446218195045
Pubmed

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

TLN2 PCNX1 BIRC6 SYNE2 SEC16A

1.20e-0522546512168954
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

TLN2 PCNX1 C2CD3 STX4 UBE4B SZT2 BIRC6 KSR2 SEC16A

1.22e-05110546935748872
Pubmed

MDC1 and RNF8 function in a pathway that directs BRCA1-dependent localization of PALB2 required for homologous recombination.

RNF8 BRCA2

1.71e-05546223038782
Pubmed

The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.

UBE4A UBE4B

2.56e-05646211802788
Pubmed

HiQuant: Rapid Postquantification Analysis of Large-Scale MS-Generated Proteomics Data.

FKBP5 KSR2

2.56e-05646227086506
Pubmed

Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation.

CASP1 NR1H2

4.77e-05846229033131
Pubmed

Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases.

CASP1 GBP5

6.12e-05946224739961
Pubmed

BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation.

RNF8 BRCA2

6.12e-05946230704900
Pubmed

U box proteins as a new family of ubiquitin-protein ligases.

UBE4A UBE4B

7.65e-051046211435423
Pubmed

Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS.

CASP1 GBP5

9.34e-051146224715728
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

NRIP1 C2CD3 NCKAP5L SEC16A

1.04e-0418446432908313
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

RABEP2 CDAN1 NIF3L1 PYGL APPL2 UBE4B BIRC6 FKBP5 SEC16A

1.04e-04145546922863883
Pubmed

LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.

CASP1 GBP5

1.12e-041246229459437
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

RNF8 NRIP1 BRCA2 NCKAP5L FKBP5 SEC16A

1.20e-0458846638580884
Pubmed

Szt2, a novel gene for seizure threshold in mice.

SZT2 MED8

1.32e-041346219624305
Pubmed

Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones.

UBE4A UBE4B

1.32e-041346215189447
Pubmed

Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida.

CASP1 GBP5

1.78e-041546225774716
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

PYGL NRIP1 NCKAP5L SYNE2 SEC16A

1.78e-0439846535016035
Pubmed

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.

CCDC62 LRRK2

2.03e-041646221292315
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

RNF8 BRCA2

2.03e-041646227760317
Pubmed

Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B.

BRCA2 SZT2

2.58e-041846216712842
Pubmed

The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.

NRIP1 PTPRO CCKAR

2.67e-049446323431145
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

PYGL BIRC6 FKBP5 SEC16A

3.21e-0424746432989298
Pubmed

ETAA1 acts at stalled replication forks to maintain genome integrity.

ETAA1 BRCA2

3.54e-042146227723720
Pubmed

Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach.

ASAP2 UBE4B BIRC6

3.80e-0410646318654987
Pubmed

A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior.

NRIP1 CCKAR

4.25e-042346235065713
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RABEP2 C2CD3 NCKAP5L BIRC6 FKBP5 SYNE2 SEC16A

4.27e-04104946727880917
Pubmed

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.

PYGL TLN2 APPL2 SYNE2 SEC16A

4.99e-0449846536634849
Pubmed

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

CASP1 GBP5

5.04e-042546235139355
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

TLN2 DLGAP3 ASAP2 UBE4B

5.21e-0428146428706196
Pubmed

Increased gene copy number of VAMP7 disrupts human male urogenital development through altered estrogen action.

NRIP1 FKBP5

6.33e-042846224880616
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

RANBP17 NRIP1 RIC8B ASAP2 UBE4B CACNA2D2 FKBP5 KSR2

6.77e-04148946828611215
Pubmed

Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun.

PYGL ZBTB6 CCKAR

8.54e-0414046326930384
Pubmed

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.

CCDC62 LRRK2

8.80e-043346225064009
Pubmed

Impact of lactobacilli on orally acquired listeriosis.

PYGL GBP5 FKBP5

1.30e-0316246323012479
Cytoband1p34.2

SZT2 MED8

1.51e-03574621p34.2
CytobandEnsembl 112 genes in cytogenetic band chr1p34

DLGAP3 SZT2 MED8

3.22e-03294463chr1p34
CytobandEnsembl 112 genes in cytogenetic band chr2p22

HEATR5B BIRC6

4.93e-03104462chr2p22
GeneFamilyU-box domain containing

UBE4A UBE4B

4.83e-057282365
GeneFamilyX-linked mental retardation|Rho GTPase activating proteins|BAR-PH domain containing

ASAP2 APPL2

3.10e-04172821291
ToppCellBL|World / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CASP1 PCNX1 GBP5 FKBP5 LRRK2

1.81e-061974651acf0191fa0a25cd20bfd9ea7bf727a1555986a1
ToppCellT_cells-Tph_and_Tfh|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

GBP5 FKBP5 SYNE2 KSR2

2.35e-05162464146058f2d60846376078916055d08f68562e3a7c
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

PCNX1 GBP5 CACNA2D2 SYNE2

3.86e-05184464791f1bcb954aadc63d4117c400537d036f68734d
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

PCNX1 GBP5 FKBP5 SYNE2

4.11e-05187464f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RANBP17 CACNA2D2 LRRC36 LRRK2

4.11e-051874645df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

PCNX1 ANKRD36 BIRC6 SYNE2

4.20e-05188464ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

RANBP17 CACNA2D2 LRRC36 LRRK2

4.20e-05188464707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellChildren_(3_yrs)-Epithelial|Children_(3_yrs) / Lineage, Cell type, age group and donor

RANBP17 CACNA2D2 LRRC36 LRRK2

4.47e-05191464e432c6e1ae82dddf84314ce73d2b7a991630d905
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RANBP17 CACNA2D2 LRRC36 LRRK2

4.56e-05192464fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 FKBP5 SYNE2

4.65e-051934646e1498153a7766c03fddbda1701dbf1596d21736
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 FKBP5 SYNE2

4.65e-05193464fce4f805e53669acb4c188f87ac7d84408c0c218
ToppCellCOVID-19_Severe-Lymphoid_T/NK-gd_T|COVID-19_Severe / Disease group, lineage and cell class

PCNX1 GBP5 CACNA2D2 SYNE2

4.84e-051954649990440bda7fac5d00ef80444fab07459be625e1
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PCNX1 GBP5 CACNA2D2 SYNE2

4.94e-051964646beaf0c2799424c59819b286fbb5c1a83d85e4d1
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCNX1 GBP5 CACNA2D2 SYNE2

4.94e-05196464c35f2349dfe35baa845f790b9f31673dceac54c0
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PCNX1 GBP5 CACNA2D2 SYNE2

4.94e-05196464418e8e0a51c5cb60e3b903e7d2d800dc8b9f3d5c
ToppCellPBMC-Severe-Lymphocyte-T/NK-Other_T-gd_T-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCNX1 GBP5 CACNA2D2 SYNE2

4.94e-05196464581fc8c8d42005aacd7b401a2c9d1fc331fb4af7
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-lymphocytic-T_lymphocytic-T_cell|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

UBE4A ANKRD36 GBP5 SYNE2

4.94e-051964644a880a5d2c7047c050c7d6dd62186f35dc5c01f7
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

RANBP17 CACNA2D2 LRRC36 LRRK2

5.24e-05199464725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

RNF8 NIF3L1 FKBP5 HDX

5.34e-05200464691b3edf7d8449556e8bf611662eb85772959f0f
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells-Neuroepithelial_cell|GW08 / Sample Type, Dataset, Time_group, and Cell type.

RNF8 NIF3L1 FKBP5 HDX

5.34e-052004644e077aa7faddcebdfc54667f8b3990704441005b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW08-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

RNF8 NIF3L1 FKBP5 HDX

5.34e-05200464d17ba4239e1fd702a3d757687110f0f2c6f91ef7
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Stem_cells-Stem_cells|GW08 / Sample Type, Dataset, Time_group, and Cell type.

RNF8 NIF3L1 FKBP5 HDX

5.34e-0520046436a110aa91a791fdf1142e7869e8aa0d342402d0
ToppCellASK440-Epithelial|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CACNA2D2 LRRC36 SYNE2 LRRK2

5.34e-05200464cb617e2a0ca82b470b473b8d5906bc8879c85718
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c2-CCL3L1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

GBP5 CACNA2D2 LRRK2

7.21e-0578463d5e2e2e04e380b265b2530e93cba6f98ad329e4f
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

PCNX1 ANKRD36 SYNE2

3.65e-04135463ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellICU-SEP-Lymphocyte-T_NK-Treg|ICU-SEP / Disease, Lineage and Cell Type

FBXO10 GBP5 SYNE2

4.50e-04145463ee99b58462f955b96d036aa67e343db047d66f64
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_4|367C / Donor, Lineage, Cell class and subclass (all cells)

ANKRD36 GBP5 SYNE2

4.50e-0414546329422c908d58081e6a748e362a7ac41bf001444c
ToppCell3'_v3-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

PCNX1 ANKRD36 KSR2

4.68e-0414746394998bc40f5c08295cfe3bdcbe43f13b1e564b3d
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PYGL CCDC62 LRRK2

5.26e-041534636a2a2379238133ce0ad714af130ffe02dd317247
ToppCellE16.5-Immune-Immune_Myeloid-Granulocytic-Neutrophil|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PYGL CCDC62 LRRK2

5.26e-04153463faa442dd925b2b09919e93c492ccc3f19803ad24
ToppCellCOVID-19_Moderate-multiplets|World / disease group, cell group and cell class

ANKRD36 GBP5 SYNE2

5.56e-04156463afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RNF8 FBXO10 GBP5

5.56e-04156463d411116d54add2d4fe649a97ac54cb94c085312f
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8|bone_marrow / Manually curated celltypes from each tissue

PCNX1 ANKRD36 SYNE2

5.56e-041564631545169694f686d28648a68b552c2ae606599d66
ToppCellT_cells-GNLY+GZMB+_T_cells|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues

GBP5 CACNA2D2 SYNE2

5.67e-04157463e9eb56a1dd96bd2e9725a20f2cf70ddeab811bd6
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

RANBP17 CACNA2D2 LRRK2

5.88e-04159463e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PYGL STX4 CCDC154

6.21e-04162463ca30d9bf61f4133566fdc91c7996e130ea554d01
ToppCellkidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANKRD36 UBE4B LRRC36

6.32e-041634631feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RANBP17 GBP5 SYNE2

6.32e-041634634dfd408aa700e307478ee35f6b902f68719d8d9e
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CACNA2D2 LRRC36 LRRK2

6.43e-04164463b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

RANBP17 SYNE2 LRRK2

6.43e-041644631cb5fbd7050650047ad6f2ca792118e98d58d22b
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CACNA2D2 LRRC36 LRRK2

6.43e-041644633aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCellfacs-Lung-EPCAM-3m-Endothelial-vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 UBE4B SZT2

6.43e-041644631d0d88132baaa3154c3e6e4ef0aff795afab08a2
ToppCellfacs-Lung-EPCAM-3m-Endothelial-Vein_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GBP5 UBE4B SZT2

6.43e-04164463bd2e10b015d5e6a338675500ec5d81dc39583b3e
ToppCell10x5'-bone_marrow-Lymphocytic_T_CD4-Tregs|bone_marrow / Manually curated celltypes from each tissue

GBP5 SYNE2 KSR2

6.55e-041654631ae1ad4e1fe19b6eefff0f9a03d58a384f169759
ToppCellPND14-Immune-Immune_Myeloid|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

6.55e-04165463e37d00084f58fbd25f66ee65be510c030167084e
ToppCell356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6|356C / Donor, Lineage, Cell class and subclass (all cells)

CDAN1 PCNX1 SYNE2

6.66e-04166463c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCellPND01-03-samps-Myeloid|PND01-03-samps / Age Group, Lineage, Cell class and subclass

CASP1 PYGL PTPRO

6.66e-0416646399dc8a186ec12d3563e81fa4618a814740332c73
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCNX1 ANKRD36 SYNE2

6.78e-0416746383969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)|367C / Donor, Lineage, Cell class and subclass (all cells)

CACNA2D2 LRRC36 LRRK2

6.90e-04168463e20e1936573fdde78426d7a4eb45c458d5c4dbb4
ToppCellPND03-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ETAA1 RIC8B PTPRO

6.90e-04168463cc0dd43d5cda01e643d8e8d74ec7617d61890760
ToppCellControl|World / group, cell type (main and fine annotations)

RANBP17 CACNA2D2 LRRC36

6.90e-04168463a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell367C-Epithelial_cells-Epithelial-B_(AT2)-|367C / Donor, Lineage, Cell class and subclass (all cells)

CACNA2D2 LRRC36 LRRK2

6.90e-0416846316b517e3159ad6e6d25fd48f7d5f46e77b2b318d
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.02e-04169463c6750c45c44be68aea39e918ba97c6f875ccea34
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.02e-041694631077fbca61bd0c1f9706aeb0552b77362127f261
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.02e-0416946370c841a7b1e3f665105d715a6d72762c80ce5de2
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.02e-0416946315d5758d94a14a909d1d0c8bba9ce497a33d1512
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NIF3L1 PYGL TLN2

7.14e-041704637534ac69ca3a378df78d61c284e89bc96a71a4a8
ToppCellnormal-na-Lymphocytic_T-T4_em-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 FKBP5 SYNE2

7.26e-0417146361318a7aaf3bd8bdd28f8a8614ab4fdf2964b3a3
ToppCellPND07-Immune-Immune_Myeloid|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.26e-04171463f68cbfa2eb1f39401a31dbd9b630023249406098
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

PCNX1 ANKRD36 SYNE2

7.26e-041714632e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-Myeloid-Monocytes|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PYGL PTPRO LRRK2

7.39e-04172463cf46810dd1072b6f2171e5d9530351ddc79a055b
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.39e-04172463e72966ced5f2ee9e24ce9fd820d99a69a482a607
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.39e-0417246383730ea3b240b8e2f2a9fb6c34dd1408050867ff
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l9|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DLGAP3 GBP5 CACNA2D2

7.51e-04173463da0f1461643294f92e20b5e456a50211a2780a91
ToppCellPND07-Immune-Immune_Myeloid-Monocytic-Macrophage|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.51e-04173463985068b149489b731a305ea9a5cfce8eafc9d289
ToppCellPND14-Immune-Immune_Myeloid-Monocytic-Macrophage|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.51e-0417346334416c583eaa21ce447d9b67bb420e35d05acc25
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.51e-041734637713716ec95932b2fac177ce4cfec027b4754cef
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C2CD3 HEATR5B GBP5

7.64e-04174463c0204a0d0a979a489e8d30dc5396e99da14c119c
ToppCellPND10-Immune-Immune_Myeloid-Monocytic-Macrophage|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CASP1 PYGL PTPRO

7.76e-04175463a8b05972e1bec4de73feaa6c4a9bcbe6b50c8044
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCNX1 SYNE2 LRRK2

7.76e-04175463cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 SYNE2

7.76e-04175463cc2428150987911d0d382e8177918724aa69f85c
ToppCellPND01-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_prolif|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DLGAP3 RIC8B ASAP2

7.89e-04176463a9e77681bcd36c382d53eb6f771349d55f98d744
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-T_mait|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 SYNE2

7.89e-04176463003076f1a983409ddf31b9c19e61c1facdd72566
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCNX1 GBP5 SYNE2

8.02e-04177463d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PCNX1 GBP5 SYNE2

8.02e-04177463f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PCNX1 GBP5 SYNE2

8.02e-04177463936ab2b180a052387124f68d0c7f41c0b164e748
ToppCellPBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PCNX1 GBP5 SYNE2

8.02e-04177463d5aeda113afaa2425874394610344570c9078478
ToppCellCOVID-19_Mild-Lymphoid_T/NK-NK_activated|COVID-19_Mild / Disease group, lineage and cell class

PCNX1 GBP5 SYNE2

8.02e-041774636978a22fef40c8b455342373abe7593f5ede0fa4
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 SYNE2

8.16e-0417846390dedb3cef9b01907b9f8eec64218d6d2072be1f
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-T4_reg|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 SYNE2

8.16e-04178463d6312286bf6cc5b107ccd7adb583d9667d4e1d21
ToppCellBAL-Mild-cDC_4|Mild / Compartment, Disease Groups and Clusters

CDAN1 SYNE2 LRRK2

8.29e-0417946368511e87b12b8253de7771e5ccfc5869248b8450
ToppCellMultiple_Sclerosis-Lymphocyte-T_NK-gdT|Multiple_Sclerosis / Disease, Lineage and Cell Type

GBP5 CACNA2D2 SYNE2

8.29e-04179463ab8d8104b38603ec7fbc5b35d7149e71ad57c43a
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PCNX1 GBP5 SYNE2

8.42e-041804636bb9f41c3a99d1bbe697f589fb2bcea9b7bfbeee
ToppCellRSV-Healthy-0|RSV / Virus stimulation, Condition and Cluster

FBXO10 GBP5 SYNE2

8.42e-04180463974044056e2f7e909cb11c6f6ca89e58bf95f7e5
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

CACNA2D2 LRRC36 LRRK2

8.42e-04180463198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TLN2 ASAP2 KSR2

8.42e-04180463023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellRSV-Healthy-0|Healthy / Virus stimulation, Condition and Cluster

FBXO10 GBP5 SYNE2

8.42e-04180463703a1d0f9536af94d56757eb01221878d7b7fe61
ToppCellnormal-na-Lymphocytic_NK-T_mait-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

GBP5 CACNA2D2 SYNE2

8.42e-04180463e66a8a61b3576ac37de7c559d16d4ed4f7a2fc78
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TLN2 ASAP2 KSR2

8.42e-04180463788d5fbf688365b5d92d3aa19b9f8e9448f8be5a
ToppCellAT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

CACNA2D2 LRRC36 LRRK2

8.56e-04181463ed0ea67f0607073aedf153f8d1073b35e46127c3
ToppCellCOVID-19_Severe-Neutrophil-|COVID-19_Severe / Disease condition and Cell class

GBP5 SYNE2 LRRK2

8.56e-041814635e5101195d5ff8c8ea7ddcf0bc4f4e03e64c01e0
ToppCellCOVID-19_Severe-Neutrophil|COVID-19_Severe / Disease condition and Cell class

GBP5 SYNE2 LRRK2

8.56e-04181463aa5e5fb0308b5e2ef918548c85529c9a433c57f5
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RANBP17 RIC8B FKBP5

8.70e-04182463eb4be1c02b8b033d025e57b8b4cdbfaec4698054
ToppCellNS-moderate-d_07-13-Myeloid-Monocyte-derived_Macrophage|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

CASP1 GBP5 FKBP5

8.70e-04182463e03e995e5fd14fc6a7559b83c0ca4e7ccc8e3d0f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

TLN2 ASAP2 KSR2

8.70e-04182463f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCellFLU-Healthy-0|FLU / Virus stimulation, Condition and Cluster

CASP1 GBP5 CCDC154

8.84e-04183463058604ddb06b3bef131183d86b83b422dae8f6cb
ToppCellnormal-na-Lymphocytic_T-CytoT_GZMK+-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

ANKRD36 GBP5 SYNE2

8.84e-0418346379defd22b3194dad16db55b9bdd220c09c1e6b90
ToppCellwk_15-18-Hematologic-Myeloid-CXCL9+_Mac|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

CASP1 GBP5 LRRK2

8.84e-0418346399a36e9c74346b619b3b87d8d6bbf9b4b797c821
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA2D2 LRRC36 LRRK2

8.84e-041834636847c1252d6bb105524f812658112517fd351eab
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

CACNA2D2 LRRC36 LRRK2

8.84e-041834638e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
DrugTerconazole [67915-31-5]; Down 200; 7.6uM; MCF7; HT_HG-U133A

ETAA1 TLN2 PCNX1 RIC8B BRCA2 FKBP5

2.65e-061964662844_DN
Drugnicotinuric acid

NR1H2 SYNE2

1.20e-053462CID000068499
Diseaseinsulin sensitivity measurement, response to polyunsaturated fatty acid supplementation

TLN2 PTPRO

1.24e-0411452EFO_0004471, EFO_0009131
DiseaseNeurobehavioral Manifestations

UBE4B FKBP5

1.49e-0412452C0525041
Diseasecutaneous squamous cell carcinoma

BRCA2 SEC16A

1.17e-0333452EFO_1001927
Diseaseresponse to serotonin-norephinephrine reuptake inhibitor

GBP5 BIRC6

1.39e-0336452EFO_0006325
DiseaseDevelopmental delay (disorder)

CACNA2D2 SZT2

1.46e-0337452C0424605
Diseasecoffee consumption measurement

RANBP17 CACNA2D2 BIRC6

2.71e-03182453EFO_0006781
Diseasenon-high density lipoprotein cholesterol measurement

STX4 APPL2 BRCA2 FKBP5 SYNE2

4.47e-03713455EFO_0005689

Protein segments in the cluster

PeptideGeneStartEntry
NNQKLMAQVLCELFQ

BIRC6

3776

Q9NR09
MECQTALQKTQLQLQ

CCDC62

101

Q6P9F0
QLQNSNITRANCNKM

CACNA2D2

381

Q9NY47
SNNRECIMQNNKFLV

FBXO10

881

Q9UK96
LKQNINICLYMNQLP

ADAD1

316

Q96M93
CQLKKQNMLLQQQLD

ANKRD36

1721

A6QL64
TKNNNQTANMCRFLL

CCKAR

186

P32238
FQNQIMKLENCVQAN

CCDC154

536

A6NI56
FVRLFQKQLLQMCQS

CDAN1

501

Q8IWY9
LQDQCQQNLVMQVLK

RANBP17

206

Q9H2T7
QQNLVMQVLKLVLNC

RANBP17

211

Q9H2T7
DCAKQMQVLLAQVQN

RABEP2

326

Q9H5N1
NPQNKAARLQISMCQ

FKBP5

381

Q13451
NGMTNQSKNCFQLIL

HDX

21

Q7Z353
QNQMLSALFQQKLQL

NCKAP5L

96

Q9HCH0
LFKNLIQNMNNIISF

ASAP2

111

O43150
SLQKALQQCELVQNM

KSR2

16

Q6VAB6
QNAKQALRNMINSSC

PCNX1

1971

Q96RV3
LLHKNQQLTMQVACL

LRRC36

646

Q1X8D7
SNIMEQKDQQFLNLC

LRRK2

681

Q5S007
SASKLLQNLAQCGMQ

NRIP1

626

P48552
MCLIENFNEQLKVNQ

GBP5

11

Q96PP8
MKNSQILSQFNQNCI

ETAA1

826

Q9NY74
LQQKSQIIVMLTQCN

PTPRO

1026

Q16827
LQNGCMNRFKNALNS

HEATR5B

1881

Q9P2D3
LQLNAIFNMLNTKNC

CASP1

256

P29466
LNQDMTCTKNPQNLN

C2CD3

736

Q4AC94
KNNKCQLILQNNIEM

BRCA2

1286

P51587
NCIGKQFAMNQLKVA

CYP4A22

456

Q5TCH4
QKVQQFFRLCQQSMD

DLGAP3

846

O95886
QNEMCLATQQLSKQL

APPL2

51

Q8NEU8
AQKQIQSLNKMCSNL

MED8

136

Q96G25
QCQQLQMFFLLLARE

SZT2

1001

Q5T011
LVLDNCINKMVNNLS

RNF8

451

O76064
MQCQDFHQLSQNLLL

SYNE2

6661

Q8WXH0
LCNIVFNSQMAQQLS

RIC8B

121

Q9NVN3
LLCNIMFFNLNRQEQ

PKDREJ

1401

Q9NTG1
MIQQLVAAQLQCNKR

NR1H2

226

P55055
SQQFVELINKCNSMQ

STX4

131

Q12846
QTRINLNCTQKALMQ

NIF3L1

206

Q9GZT8
VINFAQNKAMKCLQN

SEC16A

1511

O15027
QRNLNTDICLKNMAF

TRIM51

61

Q9BSJ1
RLAAMLNFNLQQLCG

UBE4B

1116

O95155
QAAAMQLSQCAKNLA

TLN2

1016

Q9Y4G6
LQNCLNLQVSMAVLL

UBE4A

581

Q14139
LQNTMINLGLQNACD

PYGL

96

P06737
QKMNLLRQQNLFCDV

ZBTB6

21

Q15916