Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentTRAPPII protein complex

TRAPPC2B TRAPPC2

3.50e-0412492GO:1990071
GeneOntologyCellularComponentTRAPPIII protein complex

TRAPPC2B TRAPPC2

3.50e-0412492GO:1990072
GeneOntologyCellularComponentTRAPP complex

TRAPPC2B TRAPPC2

7.16e-0417492GO:0030008
DomainHelicase_C

DHX16 CHD3 ASCC3

2.78e-03107493PF00271
DomainHELICc

DHX16 CHD3 ASCC3

2.78e-03107493SM00490
DomainHelicase_C

DHX16 CHD3 ASCC3

2.86e-03108493IPR001650
DomainHELICASE_CTER

DHX16 CHD3 ASCC3

2.93e-03109493PS51194
DomainHELICASE_ATP_BIND_1

DHX16 CHD3 ASCC3

2.93e-03109493PS51192
DomainDEXDc

DHX16 CHD3 ASCC3

2.93e-03109493SM00487
DomainHelicase_ATP-bd

DHX16 CHD3 ASCC3

3.01e-03110493IPR014001
DomainDNA/RNA_helicase_DEAH_CS

DHX16 CHD3

3.80e-0335492IPR002464
DomainDEAH_ATP_HELICASE

DHX16 CHD3

4.46e-0338492PS00690
Pubmed

Human wild-type SEDL protein functionally complements yeast Trs20p but some naturally occurring SEDL mutants do not.

TRAPPC2B TRAPPC2

2.11e-06251214597397
Pubmed

Identification of the gene (SEDL) causing X-linked spondyloepiphyseal dysplasia tarda.

TRAPPC2B TRAPPC2

2.11e-06251210431248
Pubmed

Spondyloepiphyseal dysplasia tarda (SEDL, MIM #313400).

TRAPPC2B TRAPPC2

2.11e-06251212939648
Pubmed

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy.

DHX16 CAD GANAB RRP12 BOP1 CHD3 UROD PRPF8

4.04e-0664151836057605
Pubmed

Relationship between the expression of CES2, UGT1A1, and GUSB in colorectal cancer tissues and aberrant methylation.

GUSB CES2

6.32e-06351224195516
Pubmed

Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE.

CYP2C9 FMO4 CES2

1.17e-053051320529763
Pubmed

RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.

CAD RRP12 CHD3 ASCC3 PRPF8

1.19e-0520251524639526
Pubmed

A novel 16-kilodalton cellular protein physically interacts with and antagonizes the functional activity of c-myc promoter-binding protein 1.

TRAPPC2B TRAPPC2

1.26e-05451211134351
Pubmed

RNA ligase-like domain in activating signal cointegrator 1 complex subunit 1 (ASCC1) regulates ASCC complex function during alkylation damage.

ASCC3 PRPF8

1.26e-05451229997253
Pubmed

The mammalian analogue of the yeast PRP8 splicing protein is present in the U4/5/6 small nuclear ribonucleoprotein particle and the spliceosome.

DHX16 PRPF8

1.26e-0545122479028
Pubmed

Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes.

GUSB HPS4

3.15e-0565126980940
Pubmed

Functional organization of the yeast proteome by systematic analysis of protein complexes.

TRAPPC2B TRAPPC2

4.41e-05751211805826
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX16 CAD GANAB RRP12 BOP1 ASCC3 PRPF8

4.50e-0565351722586326
Pubmed

Gene structure and expression study of the SEDL gene for spondyloepiphyseal dysplasia tarda.

TRAPPC2B TRAPPC2

5.87e-05851211031107
Pubmed

Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.

GUSB HPS4

5.87e-0585122787378
Pubmed

Derlin-1 promotes ubiquitylation and degradation of the epithelial Na+ channel, ENaC.

CAD GANAB SCNN1B

7.38e-055551328137758
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

DHX16 CAD RRP12 ALDH1B1 ASCC3 PRPF8

7.63e-0548651630940648
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

DHX16 CAD GANAB RRP12 BOP1 CHD3 ASCC3 PRPF8

1.14e-04102451824711643
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

CAD GANAB NRDC RRP12 INTS9 CHD3 ALDH1B1 ASCC3 PRPF8

1.25e-04133551929229926
Pubmed

STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.

GANAB RRP12 UROD PRPF8

1.84e-0419251432176739
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

CAD GANAB RRP12 PPP1R13B INTS9 PRPF8

1.87e-0457351628330616
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

DHX16 CAD GANAB NRDC RRP12 BOP1 ALDH1B1 PRPF8 TMEM117

2.04e-04142551930948266
Pubmed

TRAPP Complexes in Secretion and Autophagy.

TRAPPC2B TRAPPC2

2.19e-041551227066478
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

CAD RRP12 ASCC3 PRPF8

2.23e-0420251433005030
Pubmed

A high-throughput approach for measuring temporal changes in the interactome.

DTD1 PRUNE2 GANAB NRDC INTS9 BOP1 ALDH1B1 UROD DPP8

2.38e-04145551922863883
Pubmed

Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.

CAD GANAB GUSB ALDH1B1 PRPF8 MGRN1

2.69e-0461351622268729
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

DHX16 CAD GANAB MSMO1 RRP12 BOP1 ASCC3 PRPF8

6.22e-04131851830463901
Pubmed

Repression of rRNA transcription by PARIS contributes to Parkinson's disease.

CAD RRP12 ALDH1B1 PRPF8

6.85e-0427251425315684
Pubmed

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.

CAD GANAB RRP12 ASCC3 PRPF8

7.09e-0448451531995728
Pubmed

SARS-CoV-2 NSP12 associates with TRiC and the P323L substitution acts as a host adaption.

CAD GANAB ALDH1B1

7.39e-0412051337929963
Pubmed

Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

WSB1 TRPM3 MYPN ASCC3 CES2 TMEM117

7.78e-0475051611230166
Pubmed

Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion Permeation Transcripts in the Developing Hippocampus.

TRPM3 ST8SIA1

8.35e-042951228344592
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

CAD AFTPH RRP12 MYPN BOP1

8.43e-0450351516964243
Pubmed

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.

CAD PRPF8

8.93e-043051221575865
Pubmed

Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation.

DHX16 RRP12 BOP1

1.02e-0313451328695742
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

GANAB RRP12 INTS9 BOP1 CHD3

1.09e-0353351530554943
Pubmed

Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.

CAD RRP12 PRPF8

1.25e-0314451335681168
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

CAD GANAB AFTPH GUSB RRP12 BOP1 ASCC3 PRPF8

1.36e-03148751833957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PRUNE2 CDC42BPG ABR ATXN7 ZDHHC14 ENPP5 CHD3 MGRN1

1.37e-03148951828611215
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

DHX16 RRP12 BOP1 ASCC3

1.43e-0333251425693804
Pubmed

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

CAD GANAB RRP12 PRPF8

1.45e-0333351436779763
InteractionFMR1NB interactions

NRDC RRP12 BOP1

9.54e-0617503int:FMR1NB
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EGR4 NTNG1 CDKL4 TTC22

2.18e-051435145fb5a4ea93e5cce55d427e3b4a50a979504fad3c
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 SCNN1B INTS9 SND1-IT1

3.90e-0516651460060b03f2abfa3cc08107ab5a9f578e60e4ae16
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 SCNN1B INTS9 SND1-IT1

3.90e-05166514ec9161d388db5a257b8d125c14f9dd911d5d5d4a
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT3 SCNN1B INTS9 SND1-IT1

3.90e-051665144586d6725403f879fc96f67be579022587ce1906
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

WSB1 TRPM3 SCNN1B CHD3

4.28e-05170514928e42c51a7079c506f21c669c4e4c1a0df84d77
ToppCelldroplet-Lung-nan-21m-Myeloid-Plasmacytoid_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SDSL CDKL4 ST8SIA1 ALDH1B1

4.58e-051735148fb32a9f2dbec16de840d55b4db7e7718f5a2a7a
ToppCelldroplet-Lung-nan-21m-Myeloid-plasmacytoid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SDSL CDKL4 ST8SIA1 ALDH1B1

4.58e-05173514f663571aaae2365660a8b526c355f4bd1a124a74
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

WSB1 MSMO1 SCNN1B ASCC3

4.90e-051765143bbac5c2397535631fce8fa98f6ddb4fe0260351
ToppCellfacs-Marrow-KLS-24m-Hematologic-MPP_Fraction_A_+_HSC|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DTD1 PRUNE2 SDSL ENPP5

6.07e-05186514f14722ecc832794dc267bf3f9b8a13274c3addc1
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 TRPM3 ZDHHC14 PPP1R13B

6.07e-05186514f0c8de4f6ae9047b9108a47a2af8c5f42bc103b0
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

WSB1 TRPM3 SCNN1B TMEM117

6.33e-0518851458ccb31cdf43167872ef0fc737e6f9c51ee2e060
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|368C / Donor, Lineage, Cell class and subclass (all cells)

FMO4 ENPP5 INTS9 CES2

6.46e-05189514610d7cc1fc923dbd67d3b71f94d529a658982f87
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

FMO4 ENPP5 INTS9 CES2

6.73e-05191514cadb7a9de16f4bb21606de0e25cddd2d748c7f0b
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

WSB1 MSMO1 TRPM3 SCNN1B

7.44e-05196514142fd80ff74979cc2f9088fc3fcbfed374afb973
DrugDilazep dihydrochloride [20153-98-4]; Up 200; 6uM; PC3; HT_HG-U133A

PRUNE2 MSMO1 RNPEPL1 TESK2 ZDHHC14 RCN3

4.37e-061925167364_UP
DrugMonocrotaline [315-22-0]; Up 200; 12.2uM; HL60; HG-U133A

ATXN7 HPS4 RRP12 INTS9 CHD3 CES2

5.52e-062005161757_UP
DrugTTMS

CYP2C9 UROD MGRN1

5.81e-0616513CID000007215
DiseaseX-linked spondyloepiphyseal dysplasia tarda (implicated_via_orthology)

TRAPPC2B TRAPPC2

2.81e-062502DOID:0080362 (implicated_via_orthology)
Diseaseimmature platelet count

TRPM3 RNPEPL1 TESK2 ZDHHC14

3.19e-05106504EFO_0803544
Diseasespondyloepiphyseal dysplasia congenita (implicated_via_orthology)

TRAPPC2B TRAPPC2

4.20e-056502DOID:14789 (implicated_via_orthology)
Diseaseimmature platelet fraction

TRPM3 RNPEPL1 TESK2 ZDHHC14

4.24e-05114504EFO_0009187
Diseaseimmature platelet measurement

TRPM3 RNPEPL1 TESK2 ZDHHC14

5.02e-05119504EFO_0803541
Diseaseputamen volume

FAT3 ASCC3

1.27e-0331502EFO_0006932
Diseaseplatelet measurement

TRPM3 RNPEPL1 ZDHHC14 ALDH1B1

1.99e-03315504EFO_0005036

Protein segments in the cluster

PeptideGeneStartEntry
SPQVHPFPDHELEDM

ABR

366

Q12979
EPAVDFFSGDVMIHP

BOP1

221

Q14137
KEEFVPSNHFMPIHE

AFTPH

56

Q6ULP2
IPMDGQHFCFTRHEP

ALDH1B1

161

P30837
NGFFHGISIPEPEDM

CDKL4

231

Q5MAI5
GIHDLMHFDFLDPPP

DHX16

771

O60231
GNERPIPFDHMMYEH

PPP1R13B

51

Q96KQ4
EELTAFLHPEEFPHM

RCN3

186

Q96D15
GHPSLRFGDVVHFME

INTS9

396

Q9NV88
GKIMNHEDHLQFPPD

CDC42BPG

286

Q6DT37
KVHHEFQAPFGMEAE

MSMO1

171

Q15800
NLGHGLYPDMDPEHV

UROD

336

P06132
MEPEAFEICPYDPHH

GTSF1L

1

Q9H1H1
HFFMGGEKFDTPHPE

MGRN1

36

O60291
EMASGHFAFLHVPVP

HPS4

381

Q9NQG7
ADMHPIFLAHGPAFR

ENPP5

346

Q9UJA9
PHMKADHGDELPFVF

CES2

451

O00748
DFPFHEDYPNFMNHE

FMO4

71

P31512
EHPHDPEALFNLMSG

EGR4

196

Q05215
GLVAHMPLFAHADPS

HCN3

421

Q9P1Z3
EDMPIFGFCPAHDDF

ATXN7

131

O15265
PDFHLAMPTEQAEGF

DTD1

91

Q8TEA8
EPAHPAMALHARFAE

CHD3

1821

Q12873
IAGFHQDPPLMFTEE

GUSB

546

P08236
HDFMFVKRNDPDGPH

DPP8

81

Q6V1X1
VSPEDFVGLHMHGFR

FAT3

3656

Q8TDW7
HDNKEFPNPEMFDPH

CYP2C9

396

P11712
FPNPEMFDPHHFLDE

CYP2C9

401

P11712
RNPHHPMVLDLFGDN

SCNN1B

156

P51168
HHMTFDFVAPRPSGD

LINGO4

566

Q6UY18
HPPELMFDFEGRHPS

NTNG1

101

Q9Y2I2
LDEMSFHQFPQHPVH

SND1-IT1

76

Q9HBX3
MEDGHHQVDFLFPLT

FREM3

521

P0C091
EEEGVFHFHMEHPVP

RNPEPL1

241

Q9HAU8
EHGEHFDLFNFDPAP

PRUNE2

486

Q8WUY3
PGMEHVYGIPEHADN

GANAB

251

Q14697
LPFSGFHAMPEEFLQ

ST8SIA1

316

Q92185
GSEFMFEKAPAHHPA

RRP12

266

Q5JTH9
MDGPVAEHAKQEPFH

SDSL

1

Q96GA7
FDMHDLDHFDELPIN

ASCC3

171

Q8N3C0
FGFVDAQKEDMPPEH

PRPF8

51

Q6P2Q9
DPEINHFPFPFHELM

TRPM3

651

Q9HCF6
DDLPGLAHFLEHMVF

NRDC

226

O43847
HPEHQAGPSDMELLF

CAD

336

P27708
GHHDNPVFEMEFLPA

TRAPPC2

11

P0DI81
DEHMGHQFLTPDEAP

ZDHHC14

431

Q8IZN3
PHFMGDVDVNLPGLH

TMEM117

261

Q9H0C3
HNGDILMEFGHLFPP

WSB1

286

Q9Y6I7
DAFQHMVGDCPPDFL

TESK2

271

Q96S53
GHHDNPVFEMEFLPA

TRAPPC2B

11

P0DI82
LPGHFHLEMQLNFEP

TTC22

21

Q5TAA0
FRPHFLQAPGDMVAH

MYPN

1071

Q86TC9