Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly cGMP-activated cation channel activity	CNGB3 CNGB1 CNGA1	6.40e-06	7	115	3	GO:0005223
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	CNGB3 CNGB1 CNGA1	2.17e-05	10	115	3	GO:0005222
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	CNGB3 CNGB1 CNGA1	5.10e-05	13	115	3	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	CNGB3 CNGB1 CNGA1	5.10e-05	13	115	3	GO:0043855
GeneOntologyMolecularFunction	cGMP binding	CNGB3 CNGB1 CNGA1	9.87e-05	16	115	3	GO:0030553
GeneOntologyBiologicalProcess	regulation of heterochromatin formation	PPHLN1 MORC2 BAZ1A TASOR	8.94e-06	24	115	4	GO:0031445
GeneOntologyBiologicalProcess	positive regulation of heterochromatin formation	PPHLN1 MORC2 TASOR	4.64e-05	13	115	3	GO:0031453
GeneOntologyBiologicalProcess	positive regulation of intracellular protein transport	SEC16B AKAP5 BRCA1 GLI3 TENM1 PCM1	4.75e-05	116	115	6	GO:0090316
GeneOntologyBiologicalProcess	positive regulation of chromatin organization	PPHLN1 MORC2 TASOR	5.88e-05	14	115	3	GO:1905269
GeneOntologyBiologicalProcess	regulation of chromatin organization	PPHLN1 MORC2 BAZ1A TASOR	7.18e-05	40	115	4	GO:1902275
GeneOntologyBiologicalProcess	positive regulation of protein transport	SEC16B AKAP5 EXPH5 LEPR MALRD1 BRCA1 GLI3 TENM1 PCM1	7.57e-05	319	115	9	GO:0051222
GeneOntologyBiologicalProcess	positive regulation of establishment of protein localization	SEC16B AKAP5 EXPH5 ITGB2 LEPR MALRD1 BRCA1 GLI3 TENM1 PCM1	8.73e-05	403	115	10	GO:1904951
GeneOntologyBiologicalProcess	protein localization to heterochromatin	PPHLN1 TASOR	9.21e-05	3	115	2	GO:0097355
GeneOntologyBiologicalProcess	DNA methylation-dependent constitutive heterochromatin formation	PPHLN1 MORC2 EHMT1 TASOR	1.05e-04	44	115	4	GO:0006346
GeneOntologyCellularComponent	intracellular cyclic nucleotide activated cation channel complex	CNGB3 CNGB1 CNGA1	5.88e-06	7	117	3	GO:0017071
Domain	S_100	FLG FLG2 RPTN CRNN	2.07e-05	27	114	4	PF01023
Domain	S100_Ca-bd_sub	FLG FLG2 RPTN CRNN	2.41e-05	28	114	4	IPR013787
Domain	S_100	FLG FLG2 RPTN CRNN	2.41e-05	28	114	4	SM01394
Domain	Filaggrin	FLG FLG2	3.69e-05	2	114	2	IPR003303
Domain	cNMP-bd_CS	CNGB3 CNGB1 CNGA1	1.17e-04	16	114	3	IPR018488
Domain	S100_CABP	FLG FLG2 RPTN	5.82e-04	27	114	3	PS00303
Domain	S100/CaBP-9k_CS	FLG FLG2 RPTN	6.49e-04	28	114	3	IPR001751
Domain	zf-CW	ZCWPW1 MORC2	7.60e-04	7	114	2	PF07496
Domain	Znf_CW	ZCWPW1 MORC2	7.60e-04	7	114	2	IPR011124
Domain	ZF_CW	ZCWPW1 MORC2	7.60e-04	7	114	2	PS51050
Domain	CNMP_BINDING_1	CNGB3 CNGB1 CNGA1	9.66e-04	32	114	3	PS00888
Domain	CNMP_BINDING_2	CNGB3 CNGB1 CNGA1	9.66e-04	32	114	3	PS00889
Domain	cNMP	CNGB3 CNGB1 CNGA1	1.15e-03	34	114	3	SM00100
Domain	cNMP_binding	CNGB3 CNGB1 CNGA1	1.15e-03	34	114	3	PF00027
Domain	cNMP-bd_dom	CNGB3 CNGB1 CNGA1	1.26e-03	35	114	3	IPR000595
Domain	CNMP_BINDING_3	CNGB3 CNGB1 CNGA1	1.26e-03	35	114	3	PS50042
Domain	BROMODOMAIN_1	CECR2 BRWD3 BAZ1A	1.48e-03	37	114	3	PS00633
Domain	cNMP-bd-like	CNGB3 CNGB1 CNGA1	1.60e-03	38	114	3	IPR018490
Domain	Bromodomain	CECR2 BRWD3 BAZ1A	1.60e-03	38	114	3	PF00439
Domain	PDZ	LNX2 ERBIN PTPN3 LRRC7 AHNAK2	1.74e-03	141	114	5	PF00595
Domain	BROMODOMAIN_2	CECR2 BRWD3 BAZ1A	1.99e-03	41	114	3	PS50014
Domain	BROMO	CECR2 BRWD3 BAZ1A	2.14e-03	42	114	3	SM00297
Domain	Bromodomain	CECR2 BRWD3 BAZ1A	2.14e-03	42	114	3	IPR001487
Domain	-	CECR2 BRWD3 BAZ1A	2.14e-03	42	114	3	1.20.920.10
Domain	PDZ	LNX2 ERBIN PTPN3 LRRC7 AHNAK2	2.15e-03	148	114	5	SM00228
Domain	-	LNX2 ERBIN PTPN3 LRRC7 AHNAK2	2.27e-03	150	114	5	2.30.42.10
Domain	PDZ	LNX2 ERBIN PTPN3 LRRC7 AHNAK2	2.34e-03	151	114	5	PS50106
Domain	PDZ	LNX2 ERBIN PTPN3 LRRC7 AHNAK2	2.41e-03	152	114	5	IPR001478
Domain	-	CNGB3 CNGB1 CNGA1	3.14e-03	48	114	3	2.60.120.10
Domain	RmlC-like_jellyroll	CNGB3 CNGB1 CNGA1	3.73e-03	51	114	3	IPR014710
Domain	FN3	CMYA5 LEPR IGDCC4 GHR FNDC1	5.56e-03	185	114	5	SM00060
Domain	-	LNX2 EXPH5 RNF213 BRCA1 RNF6 BAZ1A KAT6B RUFY4	6.28e-03	449	114	8	3.30.40.10
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	NES RAP1GAP EXPH5 PPFIA1 ERBIN PTPN3 PHLDB1 STARD9 SYDE2 KIAA1217 GIGYF2 SSH2 CRYBG3 BICC1 WNK3 PCM1 AHNAK2 EXOC4	9.10e-10	861	119	18	36931259
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	EXPH5 ERBIN ATXN2 GLI3 KIAA1217 TENM1 GIGYF2 LRRC7 CRYBG3 AHNAK2 EXOC4	1.92e-09	263	119	11	34702444
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MON2 SYNE1 ERBIN IGDCC4 PHLDB1 STARD9 SPHKAP PDE4DIP GIGYF2 LRRC7 ASXL2 SPEN	1.73e-08	407	119	12	12693553
Pubmed	Segregation of a mutation in CNGB1 encoding the beta-subunit of the rod cGMP-gated channel in a family with autosomal recessive retinitis pigmentosa.	CNGB3 CNGB1 CNGA1	3.91e-08	3	119	3	11379879
Pubmed	Impaired channel targeting and retinal degeneration in mice lacking the cyclic nucleotide-gated channel subunit CNGB1.	CNGB3 CNGB1 CNGA1	1.56e-07	4	119	3	15634774
Pubmed	Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.	PPHLN1 MORC2 TASOR	1.56e-07	4	119	3	28581500
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	NES SYNE1 PPFIA1 ERBIN ZNF462 ATXN2 KIAA1217 SPHKAP PDE4DIP EHMT1 GIGYF2 LRRC7 SSH2 CABIN1 WNK3 PCM1	1.98e-07	963	119	16	28671696
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MON2 CECR2 PPFIA1 RNF213 SCEL PLEKHN1 TUBGCP5 BRWD3 EDEM3 BRCA1 GLI3 EHMT1 CRNN CRYBG3 KAT6B PCM1 ZNF646	2.70e-07	1116	119	17	31753913
Pubmed	The heteromeric cyclic nucleotide-gated channel adopts a 3A:1B stoichiometry.	CNGB3 CNGB1 CNGA1	3.89e-07	5	119	3	12432397
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	AFF2 PPFIA1 RNF213 FLG2 ERBIN PCF11 PTPN3 BRCA1 GLI3 SYDE2 EHMT1 SPEN TASOR PCM1	4.67e-07	777	119	14	35844135
Pubmed	cGMP and cyclic nucleotide-gated channels participate in mouse sperm capacitation.	CNGB3 CNGB1 CNGA1	7.75e-07	6	119	3	22192355
Pubmed	The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1.	RAP1GAP ITGB2 FYB1	7.75e-07	6	119	3	16980616
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEC16B RAP1GAP EXPH5 RNF213 MORC2 TUBGCP5 PCF11 ZNF462 SSH2 TASOR EXOC4	1.11e-06	493	119	11	15368895
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	SYNE1 CECR2 SPHKAP ASXL2 SSH2 EXOC4	1.46e-06	102	119	6	11214970
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	FLG UIMC1 AKAP5 SYNE1 PPFIA1 BAG1 PRPF6 SLC30A2 ERBIN SH3D21 PCF11 BRCA1 BAZ1A STARD9 TENM1 SPEN TASOR CFAP46	2.05e-06	1442	119	18	35575683
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	SEC16B RAD21L1 PPHLN1 PCF11 GHR PHLDB1 BAZ1A CPLANE1 SPEN	4.49e-06	361	119	9	26167880
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	CNGB3 CNGB1 CNGA1	4.61e-06	10	119	3	16382102
Pubmed	Human transcription factor protein interaction networks.	FLG UIMC1 FLG2 MORC2 ERBIN PCF11 ZNF462 BRCA1 ATXN2 GLI3 EHMT1 GIGYF2 ASXL2 CABIN1 SPEN PCM1 EXOC4	7.64e-06	1429	119	17	35140242
Pubmed	Genetic variants associated with disordered eating.	FLG CHODL FLG2 SPHKAP CRNN	1.01e-05	83	119	5	23568457
Pubmed	Expression of Nestin associates with BRCA1 mutations, a basal-like phenotype and aggressive breast cancer.	NES BRCA1	1.16e-05	2	119	2	28439082
Pubmed	Nrf2 is associated with the regulation of basal transcription activity of the BRCA1 gene.	BRCA1 NFE2L2	1.16e-05	2	119	2	23353771
Pubmed	Structural basis of the partially open central gate in the human CNGA1/CNGB1 channel explained by additional density for calmodulin in cryo-EM map.	CNGB1 CNGA1	1.16e-05	2	119	2	34971760
Pubmed	Breast cancer susceptibility gene 1 regulates oxidative damage via nuclear factor erythroid 2-related factor 2 in oral cancer cells.	BRCA1 NFE2L2	1.16e-05	2	119	2	35512617
Pubmed	Stanniocalcin1 knockdown induces ferroptosis and suppresses glycolysis in prostate cancer via the Nrf2 pathway.	STC1 NFE2L2	1.16e-05	2	119	2	36591803
Pubmed	Altered Expression of Genes Encoding Cornulin and Repetin in Atopic Dermatitis.	RPTN CRNN	1.16e-05	2	119	2	28219068
Pubmed	RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci.	UIMC1 BRCA1	1.16e-05	2	119	2	21406551
Pubmed	Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.	CNGB1 CNGA1	1.16e-05	2	119	2	22802073
Pubmed	Two biomarker-directed randomized trials in European and Chinese patients with nonsmall-cell lung cancer: the BRCA1-RAP80 Expression Customization (BREC) studies.	UIMC1 BRCA1	1.16e-05	2	119	2	25164908
Pubmed	Acute lymphoblastic leukemia in a patient with Greig cephalopolysyndactyly and interstitial deletion of chromosome 7 del(7)(p11.2 p14) involving the GLI3 and ZNFN1A1 genes.	IKZF1 GLI3	1.16e-05	2	119	2	15390181
Pubmed	Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel.	CNGB1 CNGA1	1.16e-05	2	119	2	34699778
Pubmed	RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo.	UIMC1 BRCA1	1.16e-05	2	119	2	22539352
Pubmed	Periphilin self-association underpins epigenetic silencing by the HUSH complex.	PPHLN1 TASOR	1.16e-05	2	119	2	32976585
Pubmed	NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells.	LEPR NFE2L2	1.16e-05	2	119	2	37760019
Pubmed	Somatostatin down-regulates LFA-1 activation by modulating Rap1 expression in CD4+ and CD8+ T cells.	RAP1GAP ITGB2	1.16e-05	2	119	2	15544853
Pubmed	Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.	FLG FLG2	1.16e-05	2	119	2	24813994
Pubmed	Liraglutide Improves the Angiogenic Capability of EPC and Promotes Ischemic Angiogenesis in Mice under Diabetic Conditions through an Nrf2-Dependent Mechanism.	LEPR NFE2L2	1.16e-05	2	119	2	36497087
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	SYNE1 ERBIN ZNF462 PHLDB1 EHMT1 GIGYF2 KAT6B	1.31e-05	225	119	7	12168954
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	AKAP5 EXPH5 PPFIA1 PLEKHN1 ERBIN PTPN3 PHLDB1 CRNN SEMA6A FYB1	2.74e-05	569	119	10	30639242
Pubmed	Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.	GIGYF2 SPEN PCM1	3.07e-05	18	119	3	19640993
Pubmed	The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response.	UIMC1 BRCA1	3.47e-05	3	119	2	17621610
Pubmed	The linker region joining the catalytic and the regulatory domains of CnA is essential for binding to NFAT.	AKAP5 CABIN1	3.47e-05	3	119	2	15671033
Pubmed	Blood-brain barrier disruption in diabetic mice is linked to Nrf2 signaling deficits: Role of ABCB10?	LEPR NFE2L2	3.47e-05	3	119	2	28572033
Pubmed	CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response.	UIMC1 BRCA1	3.47e-05	3	119	2	17643122
Pubmed	CCDC98 targets BRCA1 to DNA damage sites.	UIMC1 BRCA1	3.47e-05	3	119	2	17643121
Pubmed	Nrf2-Mediated Regulation of Skeletal Muscle Glycogen Metabolism.	LEPR NFE2L2	3.47e-05	3	119	2	27044864
Pubmed	Co-operation of BRCA1 and POH1 relieves the barriers posed by 53BP1 and RAP80 to resection.	UIMC1 BRCA1	3.47e-05	3	119	2	24013561
Pubmed	Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop.	NES NFE2L2	3.47e-05	3	119	2	31695040
Pubmed	Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.	MORC2 TASOR	3.47e-05	3	119	2	29211708
Pubmed	Defective Nrf2-dependent redox signalling contributes to microvascular dysfunction in type 2 diabetes.	LEPR NFE2L2	3.47e-05	3	119	2	23715558
Pubmed	GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.	FLG FLG2	3.47e-05	3	119	2	28928464
Pubmed	Restore the brake on tumor progression.	NES GLI3	3.47e-05	3	119	2	28389227
Pubmed	Growth factor receptor-bound protein 14: a new modulator of photoreceptor-specific cyclic-nucleotide-gated channel.	CNGB1 CNGA1	3.47e-05	3	119	2	20890309
Pubmed	The B3 Subunit of the Cone Cyclic Nucleotide-gated Channel Regulates the Light Responses of Cones and Contributes to the Channel Structural Flexibility.	CNGB3 CNGB1	3.47e-05	3	119	2	26893377
Pubmed	RAP80 and BRCA1 PARsylation protect chromosome integrity by preventing retention of BRCA1-B/C complexes in DNA repair foci.	UIMC1 BRCA1	3.47e-05	3	119	2	31932421
Pubmed	Model for growth hormone receptor activation based on subunit rotation within a receptor dimer.	LEPR GHR	3.47e-05	3	119	2	16116438
Pubmed	CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.	BRCA1 NFE2L2	3.47e-05	3	119	2	34103686
Pubmed	Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.	FLG FLG2	3.47e-05	3	119	2	32437351
Pubmed	Nestin Mediates Hedgehog Pathway Tumorigenesis.	NES GLI3	3.47e-05	3	119	2	27496710
Pubmed	MiRNA-128 regulates the proliferation and neurogenesis of neural precursors by targeting PCM1 in the developing cortex.	NES PCM1	3.47e-05	3	119	2	26883496
Pubmed	Keratinocyte-Macrophage Crosstalk by the Nrf2/Ccl2/EGF Signaling Axis Orchestrates Tissue Repair.	LEPR NFE2L2	3.47e-05	3	119	2	33238115
Pubmed	DOT1L-mediated RAP80 methylation promotes BRCA1 recruitment to elicit DNA repair.	UIMC1 BRCA1	3.47e-05	3	119	2	39172790
Pubmed	Nrf2 in ischemic neurons promotes retinal vascular regeneration through regulation of semaphorin 6A.	NFE2L2 SEMA6A	3.47e-05	3	119	2	26621751
Pubmed	Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.	FLG FLG2	3.47e-05	3	119	2	23403047
Pubmed	Identification of a membrane-less compartment regulating invadosome function and motility.	PPFIA1 PHLDB1	3.47e-05	3	119	2	29348417
Pubmed	HIV-2/SIV viral protein X counteracts HUSH repressor complex.	PPHLN1 TASOR	3.47e-05	3	119	2	29891865
Pubmed	Nrf2 ameliorates diabetic nephropathy progression by transcriptional repression of TGFβ1 through interactions with c-Jun and SP1.	LEPR NFE2L2	3.47e-05	3	119	2	25046864
Pubmed	The Keap1-Nrf2 system prevents onset of diabetes mellitus.	LEPR NFE2L2	3.47e-05	3	119	2	23716596
Pubmed	Position-effect variegation revisited: HUSHing up heterochromatin in human cells.	PPHLN1 TASOR	3.47e-05	3	119	2	26853531
Pubmed	Restoration of Nrf2 Signaling Normalizes the Regenerative Niche.	LEPR NFE2L2	3.47e-05	3	119	2	26647385
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	UIMC1 RAP1GAP CDHR2 EXPH5 PRPF6 PLD3 TUBGCP5 ERBIN OPHN1 RNF6 NFE2L2 PDE4DIP HABP2 FYB1 PCM1	3.66e-05	1293	119	15	15342556
Pubmed	Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice.	LNX2 PPFIA1 PHLDB1 SPHKAP EXOC4	3.96e-05	110	119	5	27889896
Pubmed	Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis.	NES PCM1	6.93e-05	4	119	2	20152126
Pubmed	GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.	PPHLN1 TASOR	6.93e-05	4	119	2	26022416
Pubmed	CD44-mediated phagocytosis induces inside-out activation of complement receptor-3 in murine macrophages.	RAP1GAP ITGB2	6.93e-05	4	119	2	17827392
Pubmed	Estrogen controls the survival of BRCA1-deficient cells via a PI3K-NRF2-regulated pathway.	BRCA1 NFE2L2	6.93e-05	4	119	2	24567396
Pubmed	Sulforaphane reduces obesity by reversing leptin resistance.	LEPR NFE2L2	6.93e-05	4	119	2	35323110
Pubmed	Deletion of growth hormone receptor in hypothalamic neurons affects the adaptation capacity to aerobic exercise.	LEPR GHR	6.93e-05	4	119	2	33069692
Pubmed	Loss of BRCA1-A complex function in RAP80 null tumor cells.	UIMC1 BRCA1	6.93e-05	4	119	2	22792303
Pubmed	Customized treatment in non-small-cell lung cancer based on EGFR mutations and BRCA1 mRNA expression.	UIMC1 BRCA1	6.93e-05	4	119	2	19415121
Pubmed	Genomic analysis of Meckel-Gruber syndrome in Arabs reveals marked genetic heterogeneity and novel candidate genes.	CPLANE1 EXOC4	6.93e-05	4	119	2	23169490
Pubmed	BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival.	BRCA1 NFE2L2	6.93e-05	4	119	2	23857982
Pubmed	Nrf2 induces fibroblast growth factor 21 in diabetic mice.	LEPR NFE2L2	6.93e-05	4	119	2	25270507
Pubmed	SH2B1 enhances leptin signaling by both Janus kinase 2 Tyr813 phosphorylation-dependent and -independent mechanisms.	LEPR BRCA1	6.93e-05	4	119	2	17565041
Pubmed	Nrf2 Improves Leptin and Insulin Resistance Provoked by Hypothalamic Oxidative Stress.	LEPR NFE2L2	6.93e-05	4	119	2	28228267
Pubmed	Cyclic nucleotide-gated channel subunit glycosylation regulates matrix metalloproteinase-dependent changes in channel gating.	CNGB3 CNGB1	6.93e-05	4	119	2	24164424
Pubmed	Growth hormone regulates neuroendocrine responses to weight loss via AgRP neurons.	LEPR GHR	6.93e-05	4	119	2	30737388
Pubmed	Liprin-α1, ERC1 and LL5 define polarized and dynamic structures that are implicated in cell migration.	PPFIA1 PHLDB1	6.93e-05	4	119	2	24982445
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	UIMC1 LNX2 PPFIA1 IKZF1 HSFY1 KIAA1217 PDE4DIP PCM1 RUFY4	7.21e-05	514	119	9	29892012
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	UIMC1 ATG2B MORC2 ERBIN KARS1 BRCA1 CABIN1 SPEN PCM1 EXOC4	7.81e-05	645	119	10	25281560
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	PPFIA1 ATG2B ZNF462 GIGYF2 CRYBG3 TASOR PCM1 EXOC4	9.99e-05	418	119	8	34709266
Pubmed	Parkinson Disease Overview	ATXN2 FBXO7 GIGYF2	1.08e-04	27	119	3	20301402
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	UIMC1 SALL3 PPHLN1 PRPF6 PCF11 BRCA1 ATXN2 BAZ1A GIGYF2 SPEN TASOR PCM1	1.09e-04	954	119	12	36373674
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	NES RAP1GAP SYNE1 PPFIA1 PLD3 ERBIN OPHN1 PHLDB1 KARS1 KIAA1217 PDE4DIP LRRC7 SSH2 PCM1 EXOC4	1.14e-04	1431	119	15	37142655
Pubmed	Reverse genetics reveals single gene of every candidate on Hybrid sterility, X Chromosome QTL 2 (Hstx2) are dispensable for spermatogenesis.	AFF2 FMR1NB	1.15e-04	5	119	2	32493902
Pubmed	Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells.	UIMC1 BRCA1	1.15e-04	5	119	2	26446986
Pubmed	Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function.	UIMC1 BRCA1	1.15e-04	5	119	2	19305427
Pubmed	The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.	ZCWPW1 MORC2	1.15e-04	5	119	2	14607086
Pubmed	Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.	UIMC1 BRCA1	1.15e-04	5	119	2	17525342
Pubmed	Growth hormone enhances the recovery of hypoglycemia via ventromedial hypothalamic neurons.	LEPR GHR	1.15e-04	5	119	2	31366244
Pubmed	The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection.	UIMC1 BRCA1	1.15e-04	5	119	2	21335604
Interaction	YWHAH interactions	NES RAP1GAP EXPH5 PPFIA1 BAG1 PPHLN1 PRPF6 ERBIN PTPN3 PHLDB1 STARD9 SYDE2 KIAA1217 GIGYF2 SSH2 CRYBG3 BICC1 WNK3 PCM1 AHNAK2 EXOC4	1.15e-06	1102	116	21	int:YWHAH
GeneFamily	EF-hand domain containing\|S100 fused type protein family	FLG FLG2 RPTN CRNN	9.99e-09	7	76	4	1350
GeneFamily	Cyclic nucleotide gated channels	CNGB3 CNGB1 CNGA1	8.39e-06	10	76	3	250
GeneFamily	Zinc fingers MYND-type\|A-kinase anchoring proteins	AKAP5 CMYA5 SPHKAP	2.41e-04	29	76	3	396
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	UIMC1 BRCA1	2.59e-04	6	76	2	1328
GeneFamily	Zinc fingers CW-type	ZCWPW1 MORC2	3.61e-04	7	76	2	96
GeneFamily	PDZ domain containing	LNX2 ERBIN PTPN3 LRRC7 AHNAK2	4.49e-04	152	76	5	1220
GeneFamily	Fibronectin type III domain containing	CMYA5 IGDCC4 GHR FNDC1	4.62e-03	160	76	4	555
GeneFamily	Ataxins\|Trinucleotide repeat containing	ATXN2 GIGYF2	4.91e-03	25	76	2	775
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000_k-means-cluster#3	RAP1GAP LNX2 AFF2 SYNE1 MDM1 RNF213 PPHLN1 PRPF6 BRWD3 BCLAF3 BAZ1A NFE2L2 GLI3 ASXL2 CNGA1 PCM1	1.55e-09	432	115	16	Facebase_RNAseq_e10.5_Maxillary Arch_1000_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_1000	RAP1GAP LNX2 AFF2 SYNE1 CECR2 MDM1 RNF213 PPHLN1 IKZF1 PRPF6 BRWD3 BCLAF3 ZNF462 BAZ1A NFE2L2 GLI3 ASXL2 CNGA1 PCM1	1.46e-06	989	115	19	Facebase_RNAseq_e10.5_Maxillary Arch_1000
CoexpressionAtlas	dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000	ZCWPW1 AKAP5 AFF2 RNF213 PLD3 SH3D21 IGDCC4 STC1 GHR BNC1 PTPN3 HEG1 GLI3 KIAA1217 BICC1 WNK3	6.23e-06	797	115	16	gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_500_k-means-cluster#3	RAP1GAP LNX2 AFF2 SYNE1 MDM1 RNF213 NFE2L2 GLI3 CNGA1	1.05e-05	255	115	9	Facebase_RNAseq_e10.5_Maxillary Arch_500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_500	RAP1GAP LNX2 AFF2 SYNE1 CECR2 MDM1 RNF213 IKZF1 BAZ1A NFE2L2 GLI3 CNGA1	1.49e-05	492	115	12	Facebase_RNAseq_e10.5_Maxillary Arch_500
CoexpressionAtlas	dev gonad_e12.5_F_GermCellOvary_Oct_k-means-cluster#1_top-relative-expression-ranked_1000	RNF213 ZNF462 SYDE2 WNK3	2.01e-05	30	115	4	gudmap_dev gonad_e12.5_F_GermCellOvary_Oct_k1_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#4	UIMC1 RAP1GAP ZCWPW1 LNX2 CHODL SYNE1 MDM1 RNF213 IKZF1 FNDC1 NFE2L2 FYB1 CNGA1	5.55e-05	655	115	13	Facebase_RNAseq_e10.5_Maxillary Arch_2500_K4
CoexpressionAtlas	dev gonad_e11.5_F_SupCellPrec_Sry_top-relative-expression-ranked_1000	AFF2 RNF213 PLD3 SH3D21 BRWD3 IGDCC4 PCF11 ZNF462 PTPN3 ATXN2 NFE2L2 STARD9 KAT6B WNK3	9.65e-05	791	115	14	gudmap_dev gonad_e11.5_F_SupCellPrec_Sry_1000
CoexpressionAtlas	facebase_RNAseq_e10.5_MaxArch_2500_K3	RAP1GAP LNX2 MDM1 PPHLN1 PRPF6 LEPR BRWD3 BCLAF3 ZNF462 HEG1 BAZ1A NFE2L2 GLI3 ASXL2 SEMA6A CPLANE1 WNK3 PCM1	1.34e-04	1252	115	18	facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#4	UIMC1 CPPED1 RAP1GAP LNX2 SYNE1 MDM1 RNF213 SH3D21 IGDCC4 STARD9 GLI3 SEMA6A BICC1	1.97e-04	744	115	13	Facebase_RNAseq_e10.5_Medial Nasal Eminence_2500_K4
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_top-relative-expression-ranked_500	ZCWPW1 AKAP5 AFF2 STC1 GHR BNC1 GLI3 KIAA1217 WNK3	1.98e-04	373	115	9	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_P2_bladder stroma (LCM)_emap-30396_top-relative-expression-ranked_200	CHODL LEPR FNDC1 NFE2L2 TMEM40 AHNAK2	2.55e-04	162	115	6	gudmap_developingLowerUrinaryTract_P2_bladder stroma (LCM)_200
CoexpressionAtlas	dev gonad_e13.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_200	AFF2 RNF213 WNK3	2.88e-04	24	115	3	gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_k4_200
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000_k-means-cluster#2	LNX2 MDM1 PRPF6 HEG1 BRCA1 BAZ1A GLI3 PCM1	2.95e-04	311	115	8	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000_K2
CoexpressionAtlas	dev gonad_e13.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000	NES ZCWPW1 AKAP5 AFF2 RNF213 IGDCC4 STC1 GHR BNC1 GLI3 KIAA1217 BICC1 WNK3	3.00e-04	777	115	13	gudmap_dev gonad_e13.5_M_InterstitTestis_Sma_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_2500_k-means-cluster#1	CECR2 PPFIA1 MDM1 BAG1 PRPF6 ERBIN OPHN1 EDEM3 BRCA1 BAZ1A NFE2L2 CPLANE1 EXOC4	3.11e-04	780	115	13	Facebase_RNAseq_e10.5_Lateral Nasal Eminence_2500_K1
CoexpressionAtlas	dev gonad_e12.5_M_InterstitTestis_Sma_top-relative-expression-ranked_1000	ZCWPW1 AKAP5 AFF2 RNF213 IGDCC4 STC1 GHR BNC1 GLI3 KIAA1217 CNGA1 BICC1 WNK3	3.64e-04	793	115	13	gudmap_dev gonad_e12.5_M_InterstitTestis_Sma_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	NES SALL3 CECR2 MDM1 IKZF1 PRPF6 BRCA1 BAZ1A GLI3 PCM1	3.81e-04	498	115	10	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-CD8_NK_sig-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PATL2 SYNE1 IKZF1 ITGB2 MALRD1 CD69 FYB1	3.88e-07	169	120	7	f06118754fa62c580b4bcbecff6f9e5fdc2106a0
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-SELL+_CD8_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PATL2 RNF213 IKZF1 ITGB2 SSH2 FYB1 TRAV24	4.37e-07	172	120	7	10090b4b40f0f6f07a514e86811cadeecdf21670
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF2 PRPF6 CMYA5 ERBIN HEG1 TASOR PCM1	5.10e-07	176	120	7	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	COPD-Endothelial-VE_Capillary_A\|COPD / Disease state, Lineage and Cell class	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	6.88e-07	184	120	7	5f4f7775d488ececf086c71441defecbee9d8a9c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF213 SCEL PLEKHN1 IGDCC4 PTPN3 FYB1 BICC1	8.23e-07	189	120	7	aadb7a2de4cbe7f0958651f2739bba430b93f5c1
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RNF213 SCEL PLEKHN1 IGDCC4 PTPN3 FYB1 BICC1	8.23e-07	189	120	7	8977f3295b7df7c7474b3f371de90a82ae4bb50c
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SEC16B EYA2 IGDCC4 GHR FNDC1 LRRC7 BICC1	9.80e-07	194	120	7	439d3f17c1f4736122b330e98add9292c7036a8e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	SYNE1 CMYA5 OPHN1 ZNF462 KIAA1217 LRRC7 WNK3	1.16e-06	199	120	7	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	medial-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	1.20e-06	200	120	7	a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCell	medial-Endothelial-Capillary_Intermediate_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	1.20e-06	200	120	7	3ef7b7728615710c691aed8977e2582f19692cf9
ToppCell	distal-2-Endothelial-Capillary_Intermediate_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	1.20e-06	200	120	7	7a99f28670ffb8ece7873d8a9bcd2a3936d0255d
ToppCell	distal-Endothelial-Capillary_Intermediate_1-2\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	1.20e-06	200	120	7	43bc48413b100a06f8edd9acd812296788fcbf5b
ToppCell	distal-Endothelial-Capillary_Intermediate_1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	1.20e-06	200	120	7	4d6714d48738cdee7d535923f6dd2431e5304741
ToppCell	medial-Endothelial-Capillary_Intermediate_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NES EXPH5 OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	1.20e-06	200	120	7	707148e01e961097819a05437a842b7d3bf72b0a
ToppCell	PCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	TOPAZ1 IKZF1 SCEL ITGB2 CD69 FYB1	5.95e-06	166	120	6	f03f78cae6272c89618c0bda032ce45c4fc96baa
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NES RAP1GAP EYA2 ZNF462 SYDE2 CRNN	5.95e-06	166	120	6	8d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCell	10x5'v1-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CLIC6 PLEKHN1 ZNF462 PDE4DIP RUFY4 AHNAK2	8.86e-06	178	120	6	a28683690ab8a60eb18f3ef87ea85da4e95b22df
ToppCell	facs-Pancreas-Exocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFF2 MDM1 RTL1 SPHKAP CNGB3 PDE4DIP	8.86e-06	178	120	6	fcbbcc44271515de1969b4732b6441c012693d5f
ToppCell	COPD-Endothelial-VE_Capillary_A\|World / Disease state, Lineage and Cell class	NES OPHN1 STC1 PHLDB1 KIAA1217 SEMA6A	9.75e-06	181	120	6	61608123959483ff60f07d8467996853c4371b6a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SALL3 EXPH5 CECR2 OPHN1 NFE2L2 BICC1	1.01e-05	182	120	6	5f513bbb7125956eb528e3120de3fd776770a7c3
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-CD45____T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 EYA2 FAM241A CD69 FYB1 CNGA1	1.07e-05	184	120	6	2c8e9ddce3e60302965dcf9dee77c4fe33e4071d
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_arterial_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES SYNE1 LEPR STC1 HEG1 AHNAK2	1.10e-05	185	120	6	fa94c4a1660967f211ba095606cd0aa37d38e17a
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	CLIC6 PLEKHN1 ZNF462 PDE4DIP RUFY4 AHNAK2	1.10e-05	185	120	6	5ed49b6d8214c6119355a6d3ee4e25d40bcc0c53
ToppCell	356C-Myeloid-Macrophage-SPP1+_Macrophage_4\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	NES RAP1GAP EYA2 ZNF462 SYDE2	1.11e-05	108	120	5	ee924deacd14ea404fda80ed633960143fd474c0
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES SYNE1 LEPR STC1 HEG1 AHNAK2	1.17e-05	187	120	6	37d8ee5c8bd6324749e5a2adef1d0482c75da80c
ToppCell	3'-Adult-Appendix-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NES SYNE1 LEPR STC1 HEG1 AHNAK2	1.17e-05	187	120	6	ec98d5e480b08854dfd0ba6b1dc6610455f90640
ToppCell	Control-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	NES EXPH5 SYNE1 OPHN1 PHLDB1 KIAA1217	1.21e-05	188	120	6	88b3415e33db81726dd29c1f50c886e057af50a0
ToppCell	COPD-Endothelial-VE_Capillary_A\|Endothelial / Disease state, Lineage and Cell class	NES EXPH5 SYNE1 OPHN1 PHLDB1 KIAA1217	1.21e-05	188	120	6	1aa0e35b1c28ac847886fece16c3ef7fc6fcdd51
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-osteoclast\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	PLEKHN1 SH3D21 ZNF462 PDE4DIP RUFY4 AHNAK2	1.21e-05	188	120	6	762b52f21d2bc5409f86746a904c4358490be9c0
ToppCell	nucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	NES SYNE1 OPHN1 PHLDB1 KIAA1217 SEMA6A	1.25e-05	189	120	6	b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCell	ASK428-Epithelial-Transformed_epithelium\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	SCEL CMYA5 BNC1 HEG1 GLI3 BICC1	1.25e-05	189	120	6	87189275234b5d59484c58acbb14a09903f2b578
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_T/NK-CD8-positive,_alpha-beta_T_cell-CD8_T_cells-CD8_T_cells_L.1.1.4.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PATL2 SYNE1 RNF213 IKZF1 CD69 SSH2	1.28e-05	190	120	6	d153a0bdedcd6865e6ee19575234a78b5d859ff1
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NES SYNE1 PHLDB1 STARD9 KIAA1217 SEMA6A	1.28e-05	190	120	6	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	BL-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLG SCEL PTPN3 RPTN CRNN TMEM40	1.32e-05	191	120	6	3f9b8c4fb72ae6f3167b187e6715c4dcb3159f98
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	IKZF1 ITGB2 TENM1 CD69 FYB1 TRAV13-1	1.32e-05	191	120	6	133864ec1e89f97a82c3bb01d2a3c658397fefaf
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXPH5 MDM1 CHGB GHR SPHKAP PDE4DIP	1.32e-05	191	120	6	f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NES SYNE1 PHLDB1 STARD9 KIAA1217 SEMA6A	1.32e-05	191	120	6	f229abf69a1217194f74b0502486907e07dba989
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLG SCEL PTPN3 RPTN CRNN TMEM40	1.32e-05	191	120	6	fbd8d337b4444fba8527a614e4a8bfb516ce0f66
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	EYA2 LEPR IGDCC4 GHR GLI3 BICC1	1.36e-05	192	120	6	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	NS-critical-LOC-Epithelial-Squamous\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	FLG SCEL PTPN3 RPTN CRNN TMEM40	1.53e-05	196	120	6	453c809494ceffa2a28af283c4b5a4924fcf160f
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EXPH5 CLIC6 SCEL PTPN3 KIAA1217 AHNAK2	1.53e-05	196	120	6	3e99a367b7d817e1f1221450fcec20ad7a7c7a2a
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	EXPH5 CLIC6 SCEL PTPN3 KIAA1217 AHNAK2	1.53e-05	196	120	6	1efacc37bbfbd05b5d4db3dd10f6d9a238d23e31
ToppCell	NS-critical-d_16-33-Epithelial-Squamous\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SCEL PTPN3 HEG1 RPTN CRNN TMEM40	1.53e-05	196	120	6	97e16d9833e4083d719ca7058d5fc9b11edb37e3
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SYNE1 RNF213 IKZF1 TUBGCP5 TENM1 PCM1	1.58e-05	197	120	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	Severe_COVID-19-Epithelial-transitional_Epi\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	EXPH5 CLIC6 SCEL PTPN3 KIAA1217 AHNAK2	1.58e-05	197	120	6	5ad3cd4c77016e862041baac3076f8cc0f75c417
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	EXPH5 CLIC6 SCEL PTPN3 KIAA1217 AHNAK2	1.58e-05	197	120	6	08b371309cd790b171ed76cabc7d910e71cd2835
ToppCell	BAL-Severe-Epithelial-Epithelial-transitional_Epi\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	EXPH5 CLIC6 SCEL PTPN3 KIAA1217 AHNAK2	1.58e-05	197	120	6	9f49feee38647bbf964974aac96fa75602186b5c
ToppCell	LPS_only-Epithelial_airway-airway_epithelial\|LPS_only / Treatment groups by lineage, cell group, cell type	EXPH5 CLIC6 SCEL PLEKHN1 CRNN TMEM40	1.62e-05	198	120	6	e035380578c01b0243bfef29ca9b50cc17cce771
ToppCell	LPS_only-Epithelial_airway\|LPS_only / Treatment groups by lineage, cell group, cell type	EXPH5 CLIC6 SCEL PLEKHN1 CRNN TMEM40	1.62e-05	198	120	6	ba090210392e001a3f7bdf09371b3f0e0c8c7ef3
ToppCell	Parenchyma_COVID-19-Immune-TX-MoAM-4\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	PLD3 SLC30A2 ITGB2 SH3D21 PDE4DIP RUFY4	1.62e-05	198	120	6	a7eed9eeb728a8796e2780090cc244856efd8c65
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Airway-Club\|LPS_only / Treatment groups by lineage, cell group, cell type	EXPH5 CLIC6 SCEL PLEKHN1 CRNN TMEM40	1.67e-05	199	120	6	165ac94b2d56072ad43358b5127d77555221e2d8
ToppCell	NS-moderate-d_0-4-Epithelial\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	EXPH5 PTPN3 NFE2L2 KIAA1217 CPLANE1 PCM1	1.72e-05	200	120	6	64462a18afca3c1a8548a857924b8166058bf958
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 LEPR GHR STARD9 TENM1 BICC1	1.72e-05	200	120	6	b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SYNE1 LEPR GHR STARD9 TENM1 BICC1	1.72e-05	200	120	6	0c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCell	ASK440-Endothelial-Endothelium\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	NES LEPR PHLDB1 HEG1 SPEN	2.01e-05	122	120	5	2f76ec3b527e9528fbb006599a96e8bbdf9e0e62
ToppCell	TCGA-Bladder-Solid_Tissue_Normal-Urothelial_normal_tissue-Urothelial_normal_tissue-6\|TCGA-Bladder / Sample_Type by Project: Shred V9	FLG SCEL FLG2 RPTN CRNN	2.43e-05	127	120	5	d61b71572eab8a850ee8ce54323fb247525006e5
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD8_T-CD8_T_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PATL2 IKZF1 CD69 FYB1 CNGA1	4.59e-05	145	120	5	a9f5a32abcf3eb2c66bd65f2521a6dd4ce56c635
ToppCell	PND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	AKAP5 EXPH5 EYA2 SCEL FLG2	5.39e-05	150	120	5	6a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCell	356C-Lymphocytic-ILC-ILC-3\|356C / Donor, Lineage, Cell class and subclass (all cells)	RNF213 CD69 LRRC7 KAT6B TRAV13-1	6.11e-05	154	120	5	923f5eb8e9258105dbdbe57a5e7976ef60dae29b
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LNX2 STC1 TDP1 RUFY4 AHNAK2	6.11e-05	154	120	5	16fdafb5c64d2db321554f87129a962d113f1668
ToppCell	facs-Liver-Non-hepatocytes-3m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM74B FLG2 LEPR SPHKAP SEMA6A	6.30e-05	155	120	5	8fdda4e3657ac56188ae88ed3caf145f4d9d1567
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	SYNE1 IKZF1 TENM1 CD69 SSH2	6.90e-05	158	120	5	7274f020c0ecf216da4b6689c62bc5f49c29b6f3
ToppCell	facs-Lung-nan-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 IKZF1 ITGB2 SSH2 FYB1	7.77e-05	162	120	5	3fd6aaf0fbaffc7ab38aa25e46c37ef511e1e704
ToppCell	facs-Lung-nan-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 IKZF1 ITGB2 SSH2 FYB1	7.77e-05	162	120	5	8134f73eb76693f4f1845f643042fdc1e81c274c
ToppCell	PND28-Immune-Immune_Myeloid-Monocytic-Macrophage-AM\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	AFF2 PLD3 ITGB2 BAZ1A RUFY4	7.77e-05	162	120	5	d712bc31840ad1523e3dbf884acbb428a8995001
ToppCell	ASK428-Immune-Mast_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	CPPED1 AKAP5 TENM1 CD69 AHNAK2	7.99e-05	163	120	5	569ca0e8ce307f258910b0c75c498009a9651e6e
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|356C / Donor, Lineage, Cell class and subclass (all cells)	ZCWPW1 PLEKHN1 TUBGCP5 STARD9 CRNN	8.71e-05	166	120	5	c4f7ea1cad962b1d6ad77423d15978b68a0d6f1d
ToppCell	5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-Activated_T\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF213 ITGB2 CD69 FYB1 TASOR	8.71e-05	166	120	5	fb2cfbf1d0a0f1950dd24c08ba00ebd64b06ceb4
ToppCell	facs-GAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 FAM241A CD69 FYB1 CNGA1	8.71e-05	166	120	5	3695407e4638f3c18fbff63daba52baa9256c429
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE\|Thalamus / BrainAtlas - Mouse McCarroll V32	PHLDB1 BRCA1 SYDE2 SEMA6A TMEM40	8.96e-05	167	120	5	1e144c03409df94ccd39760842590e8ea7487e29
ToppCell	droplet-Pancreas-PANCREAS-30m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FMR1NB IKZF1 ITGB2 CD69 FYB1	9.22e-05	168	120	5	5946204d42307391bc2160abe12850815f350aea
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN_to_DP_transition,_dividing_(more_DN)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCEL MORC2 LEPR FBXO10 SYDE2	9.22e-05	168	120	5	b9db0b1e4fe54a1fe79530d15d206155a1bfac39
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Basophil\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNE1 ITGB2 CD69 SSH2 FYB1	9.48e-05	169	120	5	b23d0aaa2da333b9c69a7aee862d5a5d2a1bf79b
ToppCell	E18.5-Immune-Immune_Myeloid-Granulocytic-Basophil-Basophil_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SYNE1 ITGB2 CD69 SSH2 FYB1	9.48e-05	169	120	5	83d1bcf33872b01ea9614f608a3e4ab30df25c7e
ToppCell	3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.3\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FLG SCEL RPTN CRNN TMEM40	9.74e-05	170	120	5	13a225e32132e9717debb0d64d7c28ada974c3e6
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	SYNE1 RNF213 IKZF1 KAT6B PCM1	1.00e-04	171	120	5	2e9a20f8980b78325c52065a9c14ab3656267c05
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 EYA2 ITGB2 CD69 CNGA1	1.03e-04	172	120	5	adf016e5856bc85e7bed58aee09ade483b9dcb00
ToppCell	368C-Myeloid-Mast_cell\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 CD69 SEMA6A WNK3 AHNAK2	1.06e-04	173	120	5	8cffb4a37d30b6626188309b868ac4a62e91262f
ToppCell	368C-Myeloid-Mast_cell-\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ZNF462 CD69 SEMA6A WNK3 AHNAK2	1.06e-04	173	120	5	fb87ea74bf70aa83b458edf728c81857c8b8eb96
ToppCell	droplet-Lung-LUNG-1m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 IKZF1 ITGB2 SSH2 FYB1	1.12e-04	175	120	5	c8cfe0ac0c1ac447c626a623cc49692a0b177a1c
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MDM1 IKZF1 ITGB2 SSH2 FYB1	1.12e-04	175	120	5	61fbd8f685d3daad46449e4c0386a38886496566
ToppCell	facs-Heart-RA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PATL2 IKZF1 ITGB2 FYB1 CNGA1	1.12e-04	175	120	5	db977f18a71845ecb16ee3e6b3fb03dea4a1a8bc
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_6\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	ZCWPW1 PLEKHN1 HEG1 STARD9 CRNN	1.12e-04	175	120	5	f3a68aeb79c4935006e17a5ff3445a8ec0e33f5f
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHGB SPHKAP TENM1 GIGYF2 CNGA1	1.12e-04	175	120	5	65571d775d26a40e979dbf290a8e4320c0d9fb3f
ToppCell	facs-Heart-RA-3m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PATL2 IKZF1 ITGB2 FYB1 CNGA1	1.12e-04	175	120	5	7b38cbd73be26cf33393c6e6c804d62856a91ec3
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-naive_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EXPH5 EYA2 EDEM3 FYB1 CNGA1	1.15e-04	176	120	5	8e4600efeea095a92178cfd26d7c58db7dfc0c80
ToppCell	PND14-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PLD3 PTPN3 BRCA1 BAZ1A RUFY4	1.15e-04	176	120	5	450c25ec5eeb65425f904e0a25aaafdf5682ef9c
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 RNF213 ERBIN CPLANE1 FYB1	1.18e-04	177	120	5	d3e6c768b88b7906f3c7fdd00ba20842212c14b1
ToppCell	facs-SCAT-Fat-3m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 ITGB2 TENM1 CD69 FYB1	1.18e-04	177	120	5	ffc4c675b25ffe8bd3441ce26dd0984fef4b3b88
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SYNE1 RNF213 ERBIN CPLANE1 FYB1	1.18e-04	177	120	5	f8f101c772c043636bedd6b2ec81409b1d2599bf
ToppCell	droplet-Kidney-KIDNEY-1m-Lymphocytic-T_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IKZF1 EYA2 CD69 FYB1 CNGA1	1.18e-04	177	120	5	36da06ca9577cdb7c7b5114e604f6546b9765c08
ToppCell	COVID-19_Mild-Lymphoid_T/NK-NK_activated\|COVID-19_Mild / Disease group, lineage and cell class	SYNE1 RNF213 ERBIN CPLANE1 FYB1	1.18e-04	177	120	5	6978a22fef40c8b455342373abe7593f5ede0fa4
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-T_cells-SELL+_CD4_T\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IKZF1 ITGB2 TENM1 CD69 FYB1	1.18e-04	177	120	5	bb496fbec7cacc52847abe2b2714249c47879763
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SYNE1 RNF213 ERBIN CPLANE1 FYB1	1.18e-04	177	120	5	936ab2b180a052387124f68d0c7f41c0b164e748
ToppCell	PBMC-Mild-Lymphocyte-T/NK-NK_cell-NK_activated-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SYNE1 RNF213 ERBIN CPLANE1 FYB1	1.18e-04	177	120	5	d5aeda113afaa2425874394610344570c9078478
ToppCell	facs-Heart-RA-3m-Lymphocytic\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PATL2 IKZF1 ITGB2 CD69 CNGA1	1.21e-04	178	120	5	ba6ded4455233635a11afcf6f522c786bd81b5e0
ToppCell	Endothelial-A-Donor_05\|World / lung cells shred on cell class, cell subclass, sample id	NES LEPR HEG1 SEMA6A AHNAK2	1.24e-04	179	120	5	138fd6ba6bdbd0ad01c574168addf720b67a0fea
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_FAM95C\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	STC1 GHR KIAA1217 TENM1 CRYBG3	1.27e-04	180	120	5	b514c55e52b46e8a1a2f09ed2c59a7683367a505
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	NES AFF2 GHR PHLDB1 STARD9	1.31e-04	181	120	5	451b87ac95154bb80018b8dd245b4a6389d81411
ToppCell	RA-17._Lymphocyte\|RA / Chamber and Cluster_Paper	PATL2 IKZF1 ITGB2 CD69 FYB1	1.34e-04	182	120	5	257a7847917b6ea1d60608183d90300bfd028758
Disease	Parkinson disease	ATXN2 FBXO7 GIGYF2	8.63e-05	22	116	3	cv:C0030567
Disease	allergic disease, age at onset	FLG IKZF1 EYA2 ATXN2	1.80e-04	71	116	4	EFO_0004847, MONDO_0005271
Disease	3-hydroxyisobutyrate measurement	STC1 GIGYF2	2.27e-04	6	116	2	EFO_0010983
Disease	Esophageal carcinoma	RNF6 CRNN	3.18e-04	7	116	2	C0152018
Disease	anxiety disorder, stress-related disorder	CNGB3 GIGYF2	9.86e-04	12	116	2	EFO_0006788, EFO_0010098
Disease	Malignant neoplasm of breast	RAP1GAP SYNE1 BAG1 PPHLN1 LEPR BRCA1 TENM1 EHMT1 LRRC7 KAT6B SPEN ZNF646	1.08e-03	1074	116	12	C0006142
Disease	Chromosome Breakage	BRCA1 NFE2L2	1.35e-03	14	116	2	C0376628
Disease	Chromosome Breaks	BRCA1 NFE2L2	1.35e-03	14	116	2	C0333704
Disease	cortical thickness	MON2 MDM1 EML2 ZNF462 BNC1 PHLDB1 MALRD1 ATXN2 BAZ1A GLI3 SSH2 EXOC4	1.47e-03	1113	116	12	EFO_0004840
Disease	Disorder of eye	PRPF6 CNGB3 CPLANE1 CNGB1 CNGA1	1.54e-03	212	116	5	C0015397
Disease	Nephrosis	NES ITGB2	1.56e-03	15	116	2	C0027720
Disease	Dermatitis	FLG ITGB2	1.77e-03	16	116	2	C0011603
Disease	blood urea nitrogen measurement	PPHLN1 STC1 ZNF462 PHLDB1 ATXN2 ASXL2 BICC1	2.10e-03	452	116	7	EFO_0004741
Disease	monocyte percentage of leukocytes	AFF2 CECR2 IKZF1 LEPR BRCA1 ATXN2 CD69 SSH2 RUFY4	2.42e-03	731	116	9	EFO_0007989
Disease	unipolar depression, response to bupropion, mood disorder	CCDC195 FYB1	2.51e-03	19	116	2	EFO_0003761, EFO_0004247, EFO_0006326
Disease	coronary artery disease	PPFIA1 RNF213 PPHLN1 OPHN1 FNDC1 MALRD1 ATXN2 KIAA1217 GIGYF2 LRRC7 CABIN1 BICC1	2.62e-03	1194	116	12	EFO_0001645
Disease	chemokine (C-C motif) ligand 27 measurement	PTPN3 LRRC7 ASXL2	2.68e-03	70	116	3	EFO_0008082
Disease	obesity	SEC16B CMYA5 LEPR KIAA1217 EXOC4	2.68e-03	241	116	5	EFO_0001073
Disease	Retinitis pigmentosa	PRPF6 CNGB1 CNGA1	3.13e-03	74	116	3	cv:C0035334
Disease	blood pressure	SYNE1 EXOC4	3.36e-03	22	116	2	EFO_0004325
Disease	amblyopia	MALRD1 CNGB1	3.36e-03	22	116	2	MONDO_0001020

Protein segments in the cluster

Peptide	Gene	Start	Entry
KVNGHSEETSQSPNR	ERBIN	821	Q96RT1
GSLRTQTHPTEEQDS	CRYBG3	176	Q68DQ2
SEQSTFSIPGQESQH	AFF2	381	P51816
SENNSVTVEGHPSAD	FBXO10	251	Q9UK96
ISQTPEQATHNSERE	BNC1	621	Q01954
EQATHNSERETEQTP	BNC1	626	Q01954
TSTGQHSTVQPEVAD	CFAP46	2311	Q8IYW2
GHQEQEGESSESVVP	BRWD3	1336	Q6RI45
DLHVTSQQGSSEPVV	BAG1	156	Q99933
QAVSSHEQARSSPGE	FLG	1341	P20930
TQHPESNSAGNDVFA	CLIC6	561	Q96NY7
ANHGDPSIQTSGSEQ	BICC1	596	Q9H694
EENSLASEPQTRHGS	CECR2	221	Q9BXF3
SQPNELSGSIDHQTS	ACRV1	21	P26436
TADESSGINVHQPTA	ATG2B	201	Q96BY7
SSHGQTIPVQAFSEE	ASXL2	1376	Q76L83
ESTSNIDQGPRDHSV	BAZ1A	866	Q9NRL2
SLHPESQTVEENGTA	IGDCC4	146	Q8TDY8
DVSEHFTQNQSRPEE	RAD21L1	126	Q9H4I0
EDEIQHQTPNGTITS	OPHN1	611	O60890
DSEVSQNRSPHQESL	PTPN3	426	P26045
DVPSVSDHSQQVVDS	KAT6B	1651	Q8WYB5
NSSLHPESGQENDAT	CD69	11	Q07108
NNDTHTQEPSAQQGE	PLD3	131	Q8IV08
QAGSQHGQSESIVPE	FLG2	1676	Q5D862
SSEASQAEGRPQNVS	GLI3	876	P10071
STSVGPSEQIATDQH	HSFY1	276	Q96LI6
SHGVRVENSNPTANT	LRRC7	591	Q96NW7
HTSDFNPNSGSDQRV	ATXN2	531	Q99700
SEQTSNPTENHETTN	EDEM3	861	Q9BZQ6
NHSDSNSPREEIFQV	LNX2	326	Q8N448
VSTDAAPAVQEHQGN	CCDC195	66	A0A1B0GUA6
DSEHENSEPVTNIRN	PCM1	536	Q15154
IQPAQHIQSETSGSA	NFE2L2	86	Q16236
KSPVNEDNQDGVTHS	FYB1	431	O15117
ASDVENNEGVTNHTP	MDM1	131	Q8TC05
RQEASTGQSPEDHAS	NES	451	P48681
LDINHEQENTPSTSG	PPFIA1	221	Q13136
IVSHSENQERNDSPV	EXPH5	936	Q8NEV8
NTSNSNGHYETAVEP	LEPR	56	P48357
TTSEGCHSPEDTQQN	GOLGA6L2	61	Q8N9W4
HGEDSTPQVLTEQQA	TUBGCP5	606	Q96RT8
EHQLASSSEVQNGSP	HEG1	421	Q9ULI3
EGTPRSNHSAQDSAV	IKZF1	356	Q13422
SPSSESHQQVVAVGQ	MON2	646	Q7Z3U7
AGTHTQTPTQTVEQD	CRNN	291	Q9UBG3
QTPTQTVEQDSSHQT	CRNN	296	Q9UBG3
SPEHQSLDTQQEGGE	MORC2	856	Q9Y6X9
TEEERPQETTNQHST	PCF11	561	O94913
PTSLAETQEDHNGGQ	ITGB2	81	P05107
NHRPSVDHTQNTTDG	MALRD1	1131	Q5VYJ5
PHGTQEQDIEAASSQ	PATL2	286	C9JE40
TDVTNTEHHQPSNND	BRCA1	231	P38398
SSEKHTQRQAGSDPN	FRG2C	51	A6NGY1
QEENTSSTLTHAENP	HABP2	51	Q14520
QDSHTNTDLPPVSEQ	EXOC4	741	Q96A65
VSVTIQAHDNDEPGT	CDHR2	601	Q9BYE9
HLDSTQNTENKPTGE	BCLAF3	456	A2AJT9
QTPQDTNRASETDTH	BNIP3	71	Q12983
HQQATPDDRSQDSTA	CABIN1	1366	Q9Y6J0
GTPSDHQSQEASQFE	GIGYF2	381	Q6Y7W6
AIGSQDASTNTDPEH	CPLANE1	2551	Q9H799
ANDIHEGTSEVAQPQ	GHR	401	P10912
QDVEDSQNHTGEPVG	FAM241A	51	Q8N8J7
TDSEHSSLQNNEQPS	FBXO7	91	Q9Y3I1
DVQQSTDADTEGHSP	FNDC1	951	Q4ZHG4
SEETGHPNSSQVLQS	CMYA5	1791	Q8N3K9
SHPETQSQNSADRNV	CMYA5	3126	Q8N3K9
DDQSQKHRSPGNTTT	CENPJ	196	Q9HC77
QASPLETSETDHQQP	AKAP5	246	P24588
GNHDIGNTPTAETVE	CPPED1	126	Q9BRF8
HTDGNEQISVVSFSP	EML2	456	O95834
PNSENAHGQSLEEDS	FMR1NB	106	Q8N0W7
NHVESGVSATAESPQ	SALL3	571	Q9BXA9
SQESGEETGSQENHP	CHGB	236	P05060
KHTQDSARVNPQDGT	EHMT1	71	Q9H9B1
HDGTPENEGEETAQS	PPHLN1	361	Q8NEY8
VSEDRPQAVSSGHTQ	POM121L1P	156	Q3SYA9
EASHNVPNQSSESLA	EYA2	206	O00167
REETPQEQNQTEHST	RTL1	146	A6NKG5
QEPSTHNNRVFTDSE	SYDE2	991	Q5VT97
TGHVQSTNADDVDNP	SPATA48	326	A4D263
GSQEAEESIHPNTQE	SPHKAP	871	Q2M3C7
QHTPDQANSDRASIG	PLEKHN1	381	Q494U1
QTPQQRSVSSQEEEH	SH3D21	211	A4FU49
QGQDPSHSSDLSTIQ	SYNE1	7376	Q8NF91
TNHTTDNGVGPEEES	KARS1	56	Q15046
LQTGENHTSVDPRQT	PRPF6	191	O94906
GHVSQEPKSENSSTQ	RAP1GAP	526	P47736
VNNVTSPEFTSVQHG	nan	106	Q6P435
GGPENVQIEDSHTSQ	RUFY4	206	Q6ZNE9
GENETTQPHTRNSDS	RNF6	551	Q9Y252
RHANVNPNEDGESSS	KIAA1217	1356	Q5T5P2
EAQAGSTQDVQSSPH	TENM1	171	Q9UKZ4
QDSKGSDDTQHSPRN	TENM1	471	Q9UKZ4
NSPLVTGVEHQDQST	STARD9	2371	Q9P2P6
QDQSTETRSHSPEGN	STARD9	2381	Q9P2P6
LSQPAVQETGTVHTD	HERC2P3	1056	Q9BVR0
SATHEAEQNDSVSPR	STC1	16	P52823
QKGSTNAAPQERHES	TASOR	506	Q9UK61
HSRTQEGTEEAPIQA	AHNAK2	5541	Q8IVF2
TNQPGDTHQNVVVTE	CHODL	196	Q9H9P2
STSEESENENPHARG	CNGA1	46	P29973
AHQDVSTSPQGTEVV	CNGB1	316	Q14028
RNEEGSHPSNQSQQT	CNGB3	26	Q9NQW8
TGSEAQSSPQFQDHT	RNF213	186	Q63HN8
QSSPQFQDHTEGEDQ	RNF213	191	Q63HN8
ISAPNDGTAQRTENH	TDP1	116	Q9NUW8
DNANGEEVPHTQEIS	ZCWPW1	156	Q9H0M4
SEEHETHFQNPGNTR	TMEM74B	66	Q9NUR3
VEQSPQSLHVQEGDS	TRAV24	26	A0A0B4J272
SEGTQHDPLSQESEV	VCX2	96	Q9H322
HTQVQRAQAETGPTS	SPEN	3416	Q96T58
EAGSLSHSEQNATVP	SSH2	941	Q76I76
IVPENYSHENSQGSS	IGHMBP2	646	P38935
DNATEVNPKGHENTT	SCEL	351	O95171
VDSIQVHSSQPSGQA	SEMA6A	966	Q9H2E6
SSSQPQDNSQVHRET	TMEM40	6	Q8WWA1
PTTNGHTDESSQDQL	ZNF646	331	O15015
AESESLVNGNHTPQT	PHLDB1	161	Q86UU1
HLGPGENTVSQETSQ	SEC16B	831	Q96JE7
ISQEPNVAGEHQSTD	TOPAZ1	891	Q8N9V7
QTPIYGTEHNSENTD	ZNF462	821	Q96JM2
QPDTQDQSSHYGQTD	RPTN	381	Q6XPR3
SSIENQDVSQERPHS	UHRF1BP1	936	Q6BDS2
EEEPTTSHGQSSQGI	UIMC1	391	Q96RL1
ENVEQHPSTLSVQEG	TRAV13-1	21	A0A0B4J241
HGTTNQQEENPSVRA	SLC30A2	156	Q9BRI3
PQQHCSSVTGDNLSE	WNK3	556	Q9BYP7
LHSSEGTSPAQQQVA	PDE4DIP	326	Q5VU43