Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.41e-17	37	38	9	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.84e-17	38	38	9	GO:0070001
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-18 ERVK-8 ERVK-6 EEF1AKMT4-ECE2 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	5.33e-09	430	38	10	GO:0004175
GeneOntologyMolecularFunction	peptidase activity	ERVK-18 ERVK-8 ERVK-6 EEF1AKMT4-ECE2 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	2.74e-07	654	38	10	GO:0008233
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-8 ERVK-6 ERVK-7 POLE	7.86e-07	38	38	4	GO:0034061
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-8 ERVK-6 ERVK-7	1.04e-06	11	38	3	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-8 ERVK-6 ERVK-7	2.28e-06	14	38	3	GO:0003964
GeneOntologyMolecularFunction	structural molecule activity	ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24 MSN	4.50e-06	891	38	10	GO:0005198
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-8 ERVK-6 ERVK-7	8.26e-06	21	38	3	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-8 ERVK-6 ERVK-7	4.72e-05	37	38	3	GO:0016891
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-8 ERVK-6 ERVK-7	9.12e-05	46	38	3	GO:0016893
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	ERVK-8 SHPRH ERVK-6 ERVK-7 POLE	1.32e-04	262	38	5	GO:0140097
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-8 ERVK-6 ERVK-7 POLE	1.95e-04	152	38	4	GO:0016779
GeneOntologyMolecularFunction	zinc ion binding	ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24 POLE	2.26e-04	891	38	8	GO:0008270
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-8 ERVK-6 ERVK-7	4.55e-04	79	38	3	GO:0004521
GeneOntologyMolecularFunction	nuclease activity	ERVK-8 ERVK-6 ERVK-7 POLE	9.46e-04	231	38	4	GO:0004518
GeneOntologyMolecularFunction	catalytic activity, acting on a nucleic acid	ERVK-8 SHPRH ERVK-6 ERVK-7 VARS2 POLE	1.27e-03	645	38	6	GO:0140640
GeneOntologyMolecularFunction	transition metal ion binding	ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24 POLE	1.52e-03	1189	38	8	GO:0046914
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-8 ERVK-6 ERVK-7	2.19e-03	136	38	3	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-8 ERVK-6 ERVK-7	2.19e-03	136	38	3	GO:0004519
GeneOntologyMolecularFunction	cell adhesion molecule binding	EZR LARP1 RDX TJP3 MSN	5.29e-03	599	38	5	GO:0050839
GeneOntologyMolecularFunction	protein kinase A binding	EZR RDX	5.45e-03	58	38	2	GO:0051018
GeneOntologyBiologicalProcess	viral process	ERVK-8 ERVK-6 LARP1 CCL1 ERVK-19 ERVK-7 ERVK-21 ERVK-9 ERVK-24 PIK3C3	6.09e-09	464	37	10	GO:0016032
GeneOntologyBiologicalProcess	cell-cell fusion	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	4.15e-07	85	37	5	GO:0140253
GeneOntologyBiologicalProcess	syncytium formation by plasma membrane fusion	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	4.15e-07	85	37	5	GO:0000768
GeneOntologyBiologicalProcess	positive regulation of early endosome to late endosome transport	EZR RDX MSN	4.43e-07	9	37	3	GO:2000643
GeneOntologyBiologicalProcess	syncytium formation	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	5.22e-07	89	37	5	GO:0006949
GeneOntologyBiologicalProcess	regulation of protein localization to early endosome	EZR RDX MSN	6.32e-07	10	37	3	GO:1902965
GeneOntologyBiologicalProcess	positive regulation of protein localization to early endosome	EZR RDX MSN	6.32e-07	10	37	3	GO:1902966
GeneOntologyBiologicalProcess	DNA integration	ERVK-8 ERVK-6 ERVK-7	1.50e-06	13	37	3	GO:0015074
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-8 ERVK-6 ERVK-7 POLE	1.61e-06	48	37	4	GO:0000731
GeneOntologyBiologicalProcess	early endosome to late endosome transport	EZR RDX PIK3C3 MSN	1.90e-06	50	37	4	GO:0045022
GeneOntologyBiologicalProcess	positive regulation of protein localization to endosome	EZR RDX MSN	1.91e-06	14	37	3	GO:1905668
GeneOntologyBiologicalProcess	regulation of protein localization to endosome	EZR RDX MSN	2.38e-06	15	37	3	GO:1905666
GeneOntologyBiologicalProcess	protein localization to early endosome	EZR RDX MSN	2.93e-06	16	37	3	GO:1902946
GeneOntologyBiologicalProcess	vesicle-mediated transport between endosomal compartments	EZR RDX PIK3C3 MSN	3.01e-06	56	37	4	GO:0098927
GeneOntologyBiologicalProcess	establishment of endothelial barrier	EZR RDX TJP3 MSN	3.47e-06	58	37	4	GO:0061028
GeneOntologyBiologicalProcess	regulation of early endosome to late endosome transport	EZR RDX MSN	5.93e-06	20	37	3	GO:2000641
GeneOntologyBiologicalProcess	endothelial cell development	EZR RDX TJP3 MSN	1.26e-05	80	37	4	GO:0001885
GeneOntologyBiologicalProcess	protein localization to endosome	EZR RDX MSN	2.79e-05	33	37	3	GO:0036010
GeneOntologyBiologicalProcess	establishment or maintenance of epithelial cell apical/basal polarity	EZR CRB2 MSN	1.53e-04	58	37	3	GO:0045197
GeneOntologyBiologicalProcess	endothelial cell differentiation	EZR RDX TJP3 MSN	1.80e-04	158	37	4	GO:0045446
GeneOntologyBiologicalProcess	establishment or maintenance of bipolar cell polarity	EZR CRB2 MSN	1.96e-04	63	37	3	GO:0061245
GeneOntologyBiologicalProcess	establishment or maintenance of apical/basal cell polarity	EZR CRB2 MSN	1.96e-04	63	37	3	GO:0035088
GeneOntologyBiologicalProcess	establishment of cell polarity	EZR WWC1 CRB2 MSN	2.77e-04	177	37	4	GO:0030010
GeneOntologyBiologicalProcess	DNA-templated DNA replication	ERVK-8 ERVK-6 ERVK-7 POLE	2.84e-04	178	37	4	GO:0006261
GeneOntologyBiologicalProcess	endothelium development	EZR RDX TJP3 MSN	3.09e-04	182	37	4	GO:0003158
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-8 ERVK-6 ERVK-7	4.42e-04	83	37	3	GO:0006278
GeneOntologyBiologicalProcess	DNA biosynthetic process	ERVK-8 ERVK-6 ERVK-7 POLE	6.10e-04	218	37	4	GO:0071897
GeneOntologyBiologicalProcess	establishment of epithelial cell apical/basal polarity	EZR MSN	6.44e-04	21	37	2	GO:0045198
GeneOntologyBiologicalProcess	establishment of apical/basal cell polarity	EZR MSN	9.90e-04	26	37	2	GO:0035089
GeneOntologyBiologicalProcess	establishment or maintenance of cell polarity	EZR WWC1 CRB2 MSN	1.13e-03	257	37	4	GO:0007163
GeneOntologyBiologicalProcess	microvillus assembly	EZR RDX	1.15e-03	28	37	2	GO:0030033
GeneOntologyBiologicalProcess	establishment of monopolar cell polarity	EZR MSN	1.15e-03	28	37	2	GO:0061162
GeneOntologyBiologicalProcess	establishment or maintenance of monopolar cell polarity	EZR MSN	1.23e-03	29	37	2	GO:0061339
GeneOntologyBiologicalProcess	polarized epithelial cell differentiation	EZR MSN	1.32e-03	30	37	2	GO:0030859
GeneOntologyBiologicalProcess	epithelial cell development	EZR RDX TJP3 MSN	1.33e-03	269	37	4	GO:0002064
GeneOntologyBiologicalProcess	microvillus organization	EZR RDX	1.69e-03	34	37	2	GO:0032528
GeneOntologyCellularComponent	cell tip	EZR RDX MSN	3.14e-06	17	36	3	GO:0051286
GeneOntologyCellularComponent	cell pole	EZR RDX MSN	5.24e-06	20	36	3	GO:0060187
GeneOntologyCellularComponent	T-tubule	EZR RDX ATP2B4 MSN	1.02e-05	79	36	4	GO:0030315
GeneOntologyCellularComponent	uropod	EZR MSN	2.59e-04	14	36	2	GO:0001931
GeneOntologyCellularComponent	cell trailing edge	EZR MSN	2.99e-04	15	36	2	GO:0031254
GeneOntologyCellularComponent	sarcolemma	EZR RDX ATP2B4 MSN	3.10e-04	190	36	4	GO:0042383
GeneOntologyCellularComponent	ruffle	EZR RDX KSR1 WWC1	4.21e-04	206	36	4	GO:0001726
GeneOntologyCellularComponent	ruffle membrane	EZR KSR1 WWC1	8.46e-04	108	36	3	GO:0032587
GeneOntologyCellularComponent	microvillus	EZR RDX MSN	1.23e-03	123	36	3	GO:0005902
GeneOntologyCellularComponent	filopodium	EZR RDX MSN	1.23e-03	123	36	3	GO:0030175
GeneOntologyCellularComponent	apical plasma membrane	EZR RDX CRB2 TJP3 MSN	1.40e-03	487	36	5	GO:0016324
GeneOntologyCellularComponent	microvillus membrane	EZR MSN	1.95e-03	38	36	2	GO:0031528
GeneOntologyCellularComponent	immunological synapse	EZR STOML2	3.22e-03	49	36	2	GO:0001772
GeneOntologyCellularComponent	cell-cell junction	EZR RDX CRB2 TJP3 MSN	3.24e-03	591	36	5	GO:0005911
GeneOntologyCellularComponent	apical part of cell	EZR RDX CRB2 TJP3 MSN	3.27e-03	592	36	5	GO:0045177
GeneOntologyCellularComponent	leading edge membrane	EZR KSR1 WWC1	5.59e-03	210	36	3	GO:0031256
GeneOntologyCellularComponent	adherens junction	EZR RDX MSN	5.74e-03	212	36	3	GO:0005912
GeneOntologyCellularComponent	myelin sheath	EZR RDX MSN	6.12e-03	217	36	3	GO:0043209
GeneOntologyCellularComponent	cell projection membrane	EZR KSR1 WWC1 MSN	6.23e-03	431	36	4	GO:0031253
GeneOntologyCellularComponent	midbody	RDX MICAL3 PIK3C3	6.52e-03	222	36	3	GO:0030496
Domain	ERM_C_dom	EZR RDX MSN	1.34e-08	4	29	3	IPR011259
Domain	ERM	EZR RDX MSN	1.34e-08	4	29	3	IPR011174
Domain	ERM	EZR RDX MSN	1.34e-08	4	29	3	PF00769
Domain	Moesin_tail	EZR RDX MSN	1.17e-07	7	29	3	IPR008954
Domain	Ez/rad/moesin-like	EZR RDX MSN	4.39e-06	21	29	3	IPR000798
Domain	FERM_CS	EZR RDX MSN	6.66e-06	24	29	3	IPR019747
Domain	FERM_C	EZR RDX MSN	8.54e-06	26	29	3	PF09380
Domain	FERM_C	EZR RDX MSN	9.60e-06	27	29	3	SM01196
Domain	FERM_PH-like_C	EZR RDX MSN	9.60e-06	27	29	3	IPR018980
Domain	FERM_N	EZR RDX MSN	1.78e-05	33	29	3	IPR018979
Domain	FERM_N	EZR RDX MSN	1.78e-05	33	29	3	PF09379
Domain	FERM_M	EZR RDX MSN	4.88e-05	46	29	3	PF00373
Domain	FERM_central	EZR RDX MSN	5.91e-05	49	29	3	IPR019748
Domain	FERM_domain	EZR RDX MSN	5.91e-05	49	29	3	IPR000299
Domain	-	EZR RDX MSN	5.91e-05	49	29	3	1.20.80.10
Domain	FERM_1	EZR RDX MSN	6.28e-05	50	29	3	PS00660
Domain	FERM_2	EZR RDX MSN	6.28e-05	50	29	3	PS00661
Domain	Band_41_domain	EZR RDX MSN	6.28e-05	50	29	3	IPR019749
Domain	B41	EZR RDX MSN	6.28e-05	50	29	3	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EZR RDX MSN	6.28e-05	50	29	3	IPR014352
Domain	FERM_3	EZR RDX MSN	6.28e-05	50	29	3	PS50057
Domain	G_patch	ERVK-6 GPKOW	5.77e-04	23	29	2	SM00443
Domain	G_patch_dom	ERVK-6 GPKOW	5.77e-04	23	29	2	IPR000467
Domain	G-patch	ERVK-6 GPKOW	5.77e-04	23	29	2	PF01585
Domain	G_PATCH	ERVK-6 GPKOW	5.77e-04	23	29	2	PS50174
Domain	Ubiquitin-rel_dom	EZR RDX MSN	2.85e-03	184	29	3	IPR029071
Domain	RNaseH-like_dom	ERVK-6 POLE	5.12e-03	69	29	2	IPR012337
Pathway	WP_PTDINS45P2_IN_CYTOKINESIS_PATHWAY	EZR RDX MSN	7.19e-07	12	22	3	M45558
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	EZR RDX MSN	2.48e-05	37	22	3	MM15102
Pathway	PID_RHOA_PATHWAY	EZR RDX MSN	4.49e-05	45	22	3	M12
Pathway	REACTOME_RECYCLING_PATHWAY_OF_L1	EZR RDX MSN	5.80e-05	49	22	3	M891
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	EZR RDX PIK3C3 MSN	7.76e-05	150	22	4	M39520
Pathway	WP_REGULATION_OF_ACTIN_CYTOSKELETON	EZR RDX PIK3C3 MSN	8.17e-05	152	22	4	MM15834
Pathway	REACTOME_SENSORY_PROCESSING_OF_SOUND_BY_OUTER_HAIR_CELLS_OF_THE_COCHLEA	EZR RDX MSN	8.21e-05	55	22	3	M41823
Pathway	REACTOME_L1CAM_INTERACTIONS	EZR RDX MSN	1.55e-04	68	22	3	MM14968
Pathway	REACTOME_SENSORY_PROCESSING_OF_SOUND	EZR RDX MSN	2.24e-04	77	22	3	M41822
Pathway	REACTOME_L1CAM_INTERACTIONS	EZR RDX MSN	8.43e-04	121	22	3	M872
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-18 ERVK-8 ERVK-6 ERVK-19 ERVK-7 ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.33e-15	94	40	9	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-18 ERVK-6 ERVK-19 ERVK-7 ERVK-21	1.55e-15	5	40	5	12629516
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-8 ERVK-6 ERVK-19 ERVK-21 ERVK-9	1.22e-12	12	40	5	14557543
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-21 ERVK-25 ERVK-9 ERVK-24	1.32e-11	18	40	5	18664271
Pubmed	A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.	EZR RDX MSN	1.41e-09	3	40	3	1429901
Pubmed	The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.	EZR RDX MSN	1.41e-09	3	40	3	8479753
Pubmed	ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.	EZR RDX MSN	1.41e-09	3	40	3	32098334
Pubmed	Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.	EZR RDX MSN	1.41e-09	3	40	3	18261459
Pubmed	Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.	EZR RDX MSN	1.41e-09	3	40	3	21659656
Pubmed	Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.	EZR RDX MSN	1.41e-09	3	40	3	19064715
Pubmed	Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.	EZR RDX MSN	1.41e-09	3	40	3	31843195
Pubmed	Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection.	EZR RDX MSN	1.41e-09	3	40	3	18295815
Pubmed	Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis.	EZR RDX MSN	1.41e-09	3	40	3	12360288
Pubmed	Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.	EZR RDX MSN	1.41e-09	3	40	3	21864676
Pubmed	Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation.	EZR RDX MSN	1.41e-09	3	40	3	14613898
Pubmed	Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.	EZR RDX MSN	1.41e-09	3	40	3	22132106
Pubmed	Dynamics and function of ERM proteins during cytokinesis in human cells.	EZR RDX MSN	1.41e-09	3	40	3	28889652
Pubmed	Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes.	EZR RDX MSN	1.41e-09	3	40	3	21278069
Pubmed	Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.	EZR RDX MSN	1.41e-09	3	40	3	26555866
Pubmed	Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling.	EZR RDX MSN	1.41e-09	3	40	3	23116763
Pubmed	Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex.	EZR RDX MSN	1.41e-09	3	40	3	21451358
Pubmed	Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.	EZR RDX MSN	1.41e-09	3	40	3	23703860
Pubmed	Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading.	EZR RDX MSN	1.41e-09	3	40	3	19321616
Pubmed	Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation.	EZR RDX MSN	1.41e-09	3	40	3	16889625
Pubmed	Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.	EZR RDX MSN	1.41e-09	3	40	3	29906485
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-18 ERVK-6 ERVK-19	1.41e-09	3	40	3	10516026
Pubmed	Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.	EZR RDX MSN	1.41e-09	3	40	3	20679347
Pubmed	Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells.	EZR RDX MSN	1.41e-09	3	40	3	12385025
Pubmed	Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?	EZR RDX MSN	1.41e-09	3	40	3	25286001
Pubmed	Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import.	EZR RDX MSN	1.41e-09	3	40	3	15149851
Pubmed	Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.	EZR RDX MSN	1.41e-09	3	40	3	17977945
Pubmed	Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS.	EZR RDX MSN	1.41e-09	3	40	3	15252013
Pubmed	Effect of knockdown of ezrin, radixin, and moesin on P-glycoprotein function in HepG2 cells.	EZR RDX MSN	1.41e-09	3	40	3	21837648
Pubmed	ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.	EZR RDX MSN	1.41e-09	3	40	3	32160548
Pubmed	The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.	EZR RDX MSN	1.41e-09	3	40	3	12734202
Pubmed	ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.	EZR RDX MSN	1.41e-09	3	40	3	21352885
Pubmed	Ezrin and moesin function together to promote T cell activation.	EZR RDX MSN	1.41e-09	3	40	3	19124745
Pubmed	Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.	EZR RDX MSN	5.63e-09	4	40	3	17237445
Pubmed	The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes.	EZR RDX MSN	5.63e-09	4	40	3	21148287
Pubmed	Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells.	EZR RDX MSN	5.63e-09	4	40	3	18941185
Pubmed	Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering.	EZR RDX MSN	5.63e-09	4	40	3	15178693
Pubmed	Functional binding interaction identified between the axonal CAM L1 and members of the ERM family.	EZR RDX MSN	5.63e-09	4	40	3	12070130
Pubmed	CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.	EZR RDX MSN	5.63e-09	4	40	3	27793041
Pubmed	The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.	EZR RDX MSN	5.63e-09	4	40	3	15096511
Pubmed	Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins.	EZR RDX MSN	5.63e-09	4	40	3	20660156
Pubmed	In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.	EZR RDX MSN	5.63e-09	4	40	3	19129194
Pubmed	Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death.	EZR RDX MSN	5.63e-09	4	40	3	15818415
Pubmed	Two Sides of the Coin: Ezrin/Radixin/Moesin and Merlin Control Membrane Structure and Contact Inhibition.	EZR RDX MSN	5.63e-09	4	40	3	31018575
Pubmed	Ezrin is a component of the HIV-1 virological presynapse and contributes to the inhibition of cell-cell fusion.	EZR RDX MSN	5.63e-09	4	40	3	24760896
Pubmed	Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.	EZR RDX MSN	5.63e-09	4	40	3	19890007
Pubmed	Proteomic profiling in pancreatic cancer with and without lymph node metastasis.	EZR RDX MSN	5.63e-09	4	40	3	19152423
Pubmed	The lipid 5-phoshatase SHIP2 controls renal brush border ultrastructure and function by regulating the activation of ERM proteins.	EZR RDX MSN	5.63e-09	4	40	3	28302370
Pubmed	Anoctamin 1 (Tmem16A) Ca2+-activated chloride channel stoichiometrically interacts with an ezrin-radixin-moesin network.	EZR RDX MSN	5.63e-09	4	40	3	22685202
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-24	5.63e-09	4	40	3	10469592
Pubmed	LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation.	EZR RDX MSN	5.63e-09	4	40	3	19255442
Pubmed	Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout.	EZR RDX MSN	5.63e-09	4	40	3	9890997
Pubmed	Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.	EZR RDX MSN	5.63e-09	4	40	3	20855527
Pubmed	CD43 interaction with ezrin-radixin-moesin (ERM) proteins regulates T-cell trafficking and CD43 phosphorylation.	EZR RDX MSN	5.63e-09	4	40	3	21289089
Pubmed	The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo.	EZR RDX CRB2 MSN	5.74e-09	19	40	4	17507402
Pubmed	Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation.	EZR RDX CRB2 MSN	1.08e-08	22	40	4	27870829
Pubmed	Interplay between RAGE, CD44, and focal adhesion molecules in epithelial-mesenchymal transition of alveolar epithelial cells.	EZR RDX MSN	1.41e-08	5	40	3	21278261
Pubmed	Activated ERM protein plays a critical role in drug resistance of MOLT4 cells induced by CCL25.	EZR RDX MSN	1.41e-08	5	40	3	23326330
Pubmed	Regulation of NK cell trafficking by CD81.	EZR RDX MSN	1.41e-08	5	40	3	19830727
Pubmed	Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer).	EZR RDX MSN	1.41e-08	5	40	3	25575591
Pubmed	A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells.	EZR RDX MSN	1.41e-08	5	40	3	23063725
Pubmed	Ezrin/radixin/moesin are required for the purinergic P2X7 receptor (P2X7R)-dependent processing of the amyloid precursor protein.	EZR RDX MSN	1.41e-08	5	40	3	22891241
Pubmed	The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho.	EZR RDX MSN	1.41e-08	5	40	3	10806479
Pubmed	Vitronectin induces phosphorylation of ezrin/radixin/moesin actin-binding proteins through binding to its novel neuronal receptor telencephalin.	EZR RDX MSN	1.41e-08	5	40	3	23019340
Pubmed	Sensitivity of CYP1A1 mRNA inducibility by dioxin is the same in Cyp1a2(+/+) wild-type and Cyp1a2(-/-) null mutant mice.	EZR RDX MSN	1.41e-08	5	40	3	9464455
Pubmed	A novel role for BRCA1 in regulating breast cancer cell spreading and motility.	EZR RDX MSN	1.41e-08	5	40	3	21282464
Pubmed	Human immunodeficiency virus (HIV-1) Vpr induced downregulation of NHE1 induces alteration in intracellular pH and loss of ERM complex in target cells.	EZR RDX MSN	2.81e-08	6	40	3	17349711
Pubmed	Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes.	EZR RDX MSN	2.81e-08	6	40	3	17515952
Pubmed	Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.	EZR RDX MSN	2.81e-08	6	40	3	26209696
Pubmed	Expression of ezrin in subventricular zone neural stem cells and their progeny in adult and developing mice.	EZR RDX MSN	2.81e-08	6	40	3	23229862
Pubmed	Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2.	EZR RDX MSN	2.81e-08	6	40	3	9472040
Pubmed	Human endogenous retrovirus HERV-K(HML-2) proviruses with Rec protein coding capacity and transcriptional activity.	ERVK-6 ERVK-19 ERVK-9	2.81e-08	6	40	3	15063128
Pubmed	MYADM controls endothelial barrier function through ERM-dependent regulation of ICAM-1 expression.	EZR RDX MSN	4.92e-08	7	40	3	23264465
Pubmed	Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.	EZR RDX MSN	4.92e-08	7	40	3	22291017
Pubmed	VIP regulates CFTR membrane expression and function in Calu-3 cells by increasing its interaction with NHERF1 and P-ERM in a VPAC1- and PKCε-dependent manner.	EZR RDX MSN	7.86e-08	8	40	3	24788249
Pubmed	Finding the Unicorn, a New Mouse Model of Midfacial Clefting.	EZR RDX MSN	1.18e-07	9	40	3	31940751
Pubmed	Radixin regulates cell migration and cell-cell adhesion through Rac1.	EZR RDX MSN	1.18e-07	9	40	3	22467863
Pubmed	Survey of human genes of retroviral origin: identification and transcriptome of the genes with coding capacity for complete envelope proteins.	ERVK-6 ERVK-19 ERVK-21	1.68e-07	10	40	3	12970426
Pubmed	Podoplanin regulates mammary stem cell function and tumorigenesis by potentiating Wnt/β-catenin signaling.	EZR RDX MSN	3.08e-07	12	40	3	29361573
Pubmed	Alpha6beta4 integrin and dystroglycan cooperate to stabilize the myelin sheath.	EZR RDX MSN	3.08e-07	12	40	3	18579745
Pubmed	Embryo-uterine interaction coordinates mouse embryogenesis during implantation.	EZR RDX MSN	4.00e-07	13	40	3	37522872
Pubmed	A molecular blueprint at the apical surface establishes planar asymmetry in cochlear hair cells.	EZR RDX MSN	4.00e-07	13	40	3	24135232
Pubmed	Precise Somatotopic Thalamocortical Axon Guidance Depends on LPA-Mediated PRG-2/Radixin Signaling.	EZR RDX MSN	5.08e-07	14	40	3	27641493
Pubmed	Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation.	EZR RDX MSN	9.48e-07	17	40	3	20706633
Pubmed	VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.	EZR RDX MSN	1.14e-06	18	40	3	31068622
Pubmed	Immunohistochemical assessment of ezrin and moesin in colorectal carcinoma.	EZR MSN	1.29e-06	2	40	2	27042764
Pubmed	Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma.	EZR MSN	1.29e-06	2	40	2	25299115
Pubmed	Emerging role for ERM proteins in cell adhesion and migration.	EZR RDX	1.29e-06	2	40	2	21343695
Pubmed	Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin.	EZR MSN	1.29e-06	2	40	2	9213396
Pubmed	Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers.	EZR MSN	1.29e-06	2	40	2	12111362
Pubmed	Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.	EZR MSN	1.29e-06	2	40	2	7579708
Pubmed	VARS2 V552V variant as prognostic marker in patients with early breast cancer.	VARS2 POLE	1.29e-06	2	40	2	20503108
Pubmed	Ezrin has properties to self-associate at the plasma membrane.	EZR MSN	1.29e-06	2	40	2	7844168
Pubmed	Expression of human endogenous retrovirus type K envelope glycoprotein in insect and mammalian cells.	ERVK-6 ERVK-19	1.29e-06	2	40	2	9060628
Pubmed	Perspectives for Ezrin and Radixin in Astrocytes: Kinases, Functions and Pathology.	EZR RDX	1.29e-06	2	40	2	31382374
Pubmed	Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.	EZR MSN	1.29e-06	2	40	2	28624994
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EZR RDX MSN	3.87e-05	50	24	3	1293
ToppCell	COVID-19-kidney-PEC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MICAL3 TMEM178B WWC1 CRB2	5.46e-06	168	31	4	a086c306be430adf0632ba53e98cd8014d2de330
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	VARS2 GPKOW DCAF5 POLE	5.58e-06	169	31	4	c6e5b179461996ced6c7621dc01cec00d401f4e8
ToppCell	COVID-19-kidney-Epi_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MICAL3 TMEM178B WWC1 CRB2	6.86e-06	178	31	4	544379f5a6145429762258d426b876bb36c112f5
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EZR MICAL3 TMEM178B WWC1	9.63e-06	194	31	4	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	WDR87 POLE TJP3	1.62e-04	153	31	3	54a941950bbb848077c7bd5726da9e4b3244bd38
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	WDR87 POLE TJP3	1.62e-04	153	31	3	d7635f3d4831c02a94f53afc674847d5b51453be
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	WDR87 POLE TJP3	1.62e-04	153	31	3	69a8550418ba0fc908a84b3b85761abb6e8ca4c0
ToppCell	Posterior_cortex-Macroglia-POLYDENDROCYTE-P4-Tnr-Polydendrocyte.Tnr.Dlx1_(Dlx1)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	WDR87 POLE TJP3	1.62e-04	153	31	3	e50d20f9e553b8c3e10e187770d8abe1a43d109e
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ANO9 GPKOW ATP2B4	1.68e-04	155	31	3	5687416773809b8c478567bc54310af102b3029a
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	EZR ANO9 WWC1	2.20e-04	170	31	3	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EZR ANO9 CRB2	2.28e-04	172	31	3	9a256db817c1af1802203cc88a55d608fb328c63
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANO9 GPKOW PGBD2	2.32e-04	173	31	3	506efcaa5afd6ed5e565c4c4def6a4505fea97c5
ToppCell	droplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HYLS1 ANO9 MICAL3	2.56e-04	179	31	3	4166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EZR ANO9 CRB2	2.65e-04	181	31	3	330d4322f4c4373f706273c1f4e218b59051b7fd
ToppCell	PND28-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EZR ANO9 CRB2	2.65e-04	181	31	3	3f4d5d79c1286614514b0e8134079d6128a2a23e
ToppCell	droplet-Limb_Muscle-nan-21m-Lymphocytic-T_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EZR CCL1 TJP3	2.74e-04	183	31	3	ac70a6ec9270b1bfe089702262d4575a6c42afb4
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VARS2 WWC1 TJP3	2.87e-04	186	31	3	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	2.87e-04	186	31	3	b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	2.92e-04	187	31	3	9d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR ANO9 TJP3	2.92e-04	187	31	3	1909b65ba23d598e396f77eecae562bb59bf5d5d
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR ANO9 TJP3	3.01e-04	189	31	3	8478f433495dabe813146a1f6b00098db8ce775a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	3.01e-04	189	31	3	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	MICAL3 TMEM178B ATP2B4	3.01e-04	189	31	3	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	3.05e-04	190	31	3	989d4eefd22d66ecb857836f8fdbcf41e3047f84
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	3.10e-04	191	31	3	1cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	3.10e-04	191	31	3	3c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	EZR WWC1 CRB2	3.10e-04	191	31	3	4c4eb61e6179d2f8fc524d2f813db9cba84f67a2
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MICAL3 TMEM178B WWC1	3.10e-04	191	31	3	1c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ANO9 WWC1 TJP3	3.10e-04	191	31	3	05731ece7867659c662f952812805f947032fe10
ToppCell	P03-Epithelial-alveolar_epithelial_cell-type_I_pneumocyte\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EZR WWC1 MSN	3.15e-04	192	31	3	be5e246b2350398b985767b2fbede17a8dd8cc44
ToppCell	Epithelial\|World / shred on cell class and cell subclass (v4)	EZR WWC1 TJP3	3.15e-04	192	31	3	13a3553d9a7c78535679d23d454c63fd08f7d218
ToppCell	10x_5'_v1-Non-neoplastic-Lymphoid-NK-NK-F_2\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LARP1 EEF1AKMT4 GPKOW	3.25e-04	194	31	3	5031f324628ff12a33e84cc52157be4786e0961d
ToppCell	COVID-19-Heart-CM_2\|Heart / Disease (COVID-19 only), tissue and cell type	MICAL3 TMEM178B ATP2B4	3.30e-04	195	31	3	75fc81bddb246dca3b437fb60827b1d4fe416405
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EZR WWC1 MSN	3.34e-04	196	31	3	9790340c25f446ec655f5a0b64ec3bb44ed2e1bd
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EZR WWC1 MSN	3.34e-04	196	31	3	b9ceceeacbcf81976ce92adf044f0d0aa132632b
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	EZR WWC1 CRB2	3.40e-04	197	31	3	3f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EZR WWC1 MSN	3.40e-04	197	31	3	bbb7c106d5b96b8e95aeb3e5c293e104fceea234
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	EZR WWC1 CRB2	3.40e-04	197	31	3	965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCell	PND01-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EZR WWC1 MSN	3.40e-04	197	31	3	b0fb5774525ba05f60c635d42f14bb8d79bff17c
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	ATP2B4 POLE MSN	3.45e-04	198	31	3	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	Brain_organoid-organoid_Velasco_nature-6_mon\|organoid_Velasco_nature / Sample Type, Dataset, Time_group, and Cell type.	RDX CRB2 MSN	3.45e-04	198	31	3	a6f65bb0845d8f64f5c7edb00cee3ca5adb1a373
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / Treatment groups by lineage, cell group, cell type	VARS2 WWC1 TJP3	3.45e-04	198	31	3	655df75b9692d815c7f6910275e1f684ac63bf62
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Macroglial-Astrocyte\|10w / Sample Type, Dataset, Time_group, and Cell type.	EZR ATP2B4 CRB2	3.55e-04	200	31	3	75f5ea38fbd341b80a8058077a04447f0e0eea28
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Macroglial-Astrocyte\|3m / Sample Type, Dataset, Time_group, and Cell type.	EZR CRB2 MSN	3.55e-04	200	31	3	98d7f577b31a603bf835bf9b4ea31999445cf0e5
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Macroglial\|10w / Sample Type, Dataset, Time_group, and Cell type.	EZR ATP2B4 CRB2	3.55e-04	200	31	3	bda719369aa199902789061e223b129f70a1317a
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Macroglial\|3m / Sample Type, Dataset, Time_group, and Cell type.	EZR CRB2 MSN	3.55e-04	200	31	3	38b51f337e183011e3ff32997ec26d8a424c6b78
ToppCell	MS-IIF-Lymphocyte-T/NK-ILC\|IIF / Disease, condition lineage and cell class	MICAL3 WWC1 PGBD2	3.55e-04	200	31	3	edb0b252e6ff9824908d1ff7d0d42710b00949c8
Disease	brain age measurement	EEF1AKMT4-ECE2 EEF1AKMT4	2.01e-04	20	31	2	EFO_0010602
Disease	Combined immunodeficiency	TTC7A MSN	8.54e-04	41	31	2	C0494261
Disease	antibody measurement	RDX DCAF5	1.22e-03	49	31	2	EFO_0004556
Disease	Degenerative polyarthritis	EZR MSN	4.31e-03	93	31	2	C0029408
Disease	Osteoarthrosis Deformans	EZR MSN	4.31e-03	93	31	2	C0086743
Disease	bipolar I disorder	TMEM178B ATP2B4	9.63e-03	141	31	2	EFO_0009963

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTVGWVQRHRKMLRH	CCL1	76	P22362
WDMVRRHLQGREDNL	ERVK-18	461	O42043
HWDMVRRHLQGREDN	ERVK-19	571	O71037
HWDMVRRHLQGREDN	ERVK-8	571	Q902F8
WDMVRRHLQGREDNL	ERVK-9	571	Q9UKH3
HERERDLWQENHLMR	ANKRD62	551	A6NC57
MEWIRVAVAHAGHRR	BTBD11	506	A6QL63
WVHRHEVERTKSRRM	ATF6	486	P18850
RWRHMFREQPVDEIR	ANO9	166	A1A5B4
HAEMELRRGQILWFR	ATP2B4	1081	P23634
RIQNWHEEHRGMLRE	RDX	171	P35241
HVGWVMDSREHRPRT	LARP1	831	Q6PKG0
HWTHIREREEEERMA	MICAL3	1041	Q7RTP6
REHWLEGMLRHEIGT	KIAA0895	321	Q8NCT3
IEDPRVQWRREQEHM	WWC1	81	Q8IX03
VADGAWHRVRLAMER	CRB2	951	Q5IJ48
HHWRVFRMGPREQRV	BNIPL	176	Q7Z465
RWHGEVAIRLLEMDG	KSR1	631	Q8IVT5
RRVLLWHMEQAIHSR	DCAF5	76	Q96JK2
HWLHRDLRVRFVDNM	GPKOW	356	Q92917
RIQVWHEEHRGMLRE	MSN	171	P26038
VLDWQRHGARRMIRH	POLE	1621	Q07864
HWDMVRRHLQGREDN	ERVK-7	1331	P63135
HAHVPQLRWETMDVR	EEF1AKMT4-ECE2	101	P0DPD8
EDHRKELRWGVREQM	HYLS1	231	Q96M11
WDMVRHHLQGREDNL	ERVK-24	461	P61566
HWDMVRRHLQGREDN	ERVK-25	571	P61570
HWDMVRRHLQGREDN	ERVK-6	571	Q69384
WDMVRRHLQGREDNL	ERVK-7	461	P61567
WDMVRRHLQGREDNL	ERVK-21	571	P61565
RIQVWHAEHRGMLKD	EZR	171	P15311
LHDVDQGWMRAVRKH	CHID1	126	Q9BWS9
AIQDALVRWHRMRGD	VARS2	161	Q5ST30
TIRQDEWHALHLRRM	TMEM178B	156	H3BS89
AHRQGHMVKVDWLDR	PIK3C3	181	Q8NEB9
EKRQQLHWNMHEDRR	SHPRH	16	Q149N8
HAHVPQLRWETMDVR	EEF1AKMT4	101	P0DPD7
ERHQKRHLMRVSQDW	C15orf32	151	Q32M92
RHLMRVSQDWEHLIR	C15orf32	156	Q32M92
RFDMIGHWIIHQDKR	PGBD2	546	Q6P3X8
AWVVERMGRFHRILE	STOML2	46	Q9UJZ1
HWLAVRMGRDLREQE	TJP3	521	O95049
RAEGHWDRMPELVRQ	TTC7A	21	Q9ULT0
EWIRHVLERMEAGEQ	WDR87	2526	Q6ZQQ6