Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoacylglycerol lipase activity	DAGLB ABHD12B ABHD1	1.63e-05	16	63	3	GO:0047372
GeneOntologyMolecularFunction	MAP kinase activity	MAPK14 MAPK11 MAPK13	1.63e-05	16	63	3	GO:0004707
GeneOntologyMolecularFunction	keratan sulfotransferase activity	CHST5 CHST6	5.85e-05	4	63	2	GO:0045130
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	CHST5 CHST6 TST HS3ST1	8.77e-05	74	63	4	GO:0016782
GeneOntologyMolecularFunction	N-acetylglucosamine 6-O-sulfotransferase activity	CHST5 CHST6	2.04e-04	7	63	2	GO:0001517
GeneOntologyMolecularFunction	sulfotransferase activity	CHST5 CHST6 HS3ST1	6.99e-04	55	63	3	GO:0008146
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	ELOVL4 CHRNA6 IL13RA1 TAS2R7 NRXN3 PKD1 HRH1 LRP5 OR11H12 PTCH1 GNRHR PTK7	9.43e-04	1353	63	12	GO:0004888
GeneOntologyMolecularFunction	glucosidase activity	SI GBA2	1.00e-03	15	63	2	GO:0015926
GeneOntologyMolecularFunction	Wnt receptor activity	PKD1 LRP5	1.29e-03	17	63	2	GO:0042813
GeneOntologyMolecularFunction	magnesium ion transmembrane transporter activity	SLC41A3 TMEM94	1.45e-03	18	63	2	GO:0015095
GeneOntologyBiologicalProcess	glycosaminoglycan metabolic process	CHST5 GUSB CHST6 EXT2 HS3ST1	3.17e-05	121	62	5	GO:0030203
GeneOntologyBiologicalProcess	aminoglycan metabolic process	CHST5 GUSB CHST6 EXT2 HS3ST1	4.81e-05	132	62	5	GO:0006022
GeneOntologyBiologicalProcess	glycosaminoglycan biosynthetic process	CHST5 CHST6 EXT2 HS3ST1	8.07e-05	76	62	4	GO:0006024
GeneOntologyBiologicalProcess	aminoglycan biosynthetic process	CHST5 CHST6 EXT2 HS3ST1	9.86e-05	80	62	4	GO:0006023
GeneOntologyBiologicalProcess	acylglycerol metabolic process	DAGLB LMF1 MOGAT1 ABHD12B MBOAT7	1.06e-04	156	62	5	GO:0006639
GeneOntologyBiologicalProcess	sulfur compound metabolic process	ELOVL4 CHST5 GUSB CHST6 EXT2 TST HS3ST1	1.09e-04	365	62	7	GO:0006790
GeneOntologyBiologicalProcess	neutral lipid metabolic process	DAGLB LMF1 MOGAT1 ABHD12B MBOAT7	1.13e-04	158	62	5	GO:0006638
GeneOntologyBiologicalProcess	carbohydrate metabolic process	CHST5 MAPK14 MOGAT1 GUSB CHST6 LRP5 SI EXT2 GBA2	1.26e-04	646	62	9	GO:0005975
GeneOntologyBiologicalProcess	steroid metabolic process	LMF1 TSPO TM7SF2 HRH1 LRP5 GBA2 BDH1	1.31e-04	376	62	7	GO:0008202
GeneOntologyBiologicalProcess	lipid biosynthetic process	DAGLB PIGY ELOVL4 MOGAT1 MBOAT7 TSPO TM7SF2 HRH1 ABHD1 CERS4	1.44e-04	813	62	10	GO:0008610
GeneOntologyBiologicalProcess	sulfur compound biosynthetic process	ELOVL4 CHST5 CHST6 EXT2 HS3ST1	1.97e-04	178	62	5	GO:0044272
GeneOntologyBiologicalProcess	mucopolysaccharide metabolic process	CHST5 GUSB CHST6 EXT2	2.34e-04	100	62	4	GO:1903510
GeneOntologyBiologicalProcess	glycoside catabolic process	GUSB GBA2	3.16e-04	9	62	2	GO:0016139
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGY ELOVL4 LMF1 MOGAT1 ABHD12B MBOAT7 TMEM94 TM7SF2 ALG3 EXT2 GBA2 GRAMD4 CERS4	1.05e-04	1293	63	13	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGY ELOVL4 LMF1 MOGAT1 ABHD12B MBOAT7 TMEM94 TM7SF2 ALG3 EXT2 GBA2 GRAMD4 CERS4	1.10e-04	1299	63	13	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PIGY ELOVL4 LMF1 MOGAT1 ABHD12B MBOAT7 TMEM94 TM7SF2 ALG3 EXT2 GBA2 GRAMD4 CERS4	1.36e-04	1327	63	13	GO:0042175
Domain	MAPK_p38	MAPK14 MAPK11 MAPK13	1.39e-07	4	62	3	IPR008352
Domain	MAP_kinase_CS	MAPK14 MAPK11 MAPK13	7.50e-06	12	62	3	IPR003527
Domain	MAPK	MAPK14 MAPK11 MAPK13	7.50e-06	12	62	3	PS01351
Domain	Abhydrolase_1	ABHD12B ABHD1 EPHX4	1.47e-04	31	62	3	PF00561
Domain	AB_hydrolase_1	ABHD12B ABHD1 EPHX4	1.77e-04	33	62	3	IPR000073
Domain	Carbohydrate_sulfotransferase	CHST5 CHST6	2.25e-04	7	62	2	IPR016469
Domain	Sulfotransferase_dom	CHST5 CHST6 HS3ST1	2.30e-04	36	62	3	IPR000863
Domain	Sulfotransfer_1	CHST5 CHST6 HS3ST1	2.30e-04	36	62	3	PF00685
Domain	-	DAGLB ABHD12B ABHD1 EPHX4	6.57e-04	119	62	4	3.40.50.1820
Domain	AB_hydrolase	DAGLB ABHD12B ABHD1 EPHX4	6.57e-04	119	62	4	IPR029058
Domain	TRYPSIN_SER	TPSD1 PAMR1 ACR	5.27e-03	106	62	3	PS00135
Domain	TRYPSIN_HIS	TPSD1 PAMR1 ACR	5.41e-03	107	62	3	PS00134
Domain	Peptidase_S1A	TPSD1 PAMR1 ACR	6.29e-03	113	62	3	IPR001314
Domain	TRYPSIN_DOM	TPSD1 PAMR1 ACR	6.61e-03	115	62	3	PS50240
Domain	Tryp_SPc	TPSD1 PAMR1 ACR	6.93e-03	117	62	3	SM00020
Domain	Trypsin	TPSD1 PAMR1 ACR	7.60e-03	121	62	3	PF00089
Domain	Trypsin_dom	TPSD1 PAMR1 ACR	7.60e-03	121	62	3	IPR001254
Domain	Peptidase_S1_PA	TPSD1 PAMR1 ACR	7.95e-03	123	62	3	IPR009003
Domain	EGF	NRXN3 PAMR1 LRP5	8.49e-03	126	62	3	PF00008
Pathway	KEGG_MEDICUS_PATHOGEN_SHIGELLA_OSPF_TO_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	8.33e-07	6	50	3	M47766
Pathway	WP_CANNABINOID_RECEPTOR_SIGNALING	DAGLB MAPK14 MAPK11 MAPK13	3.12e-06	29	50	4	M39676
Pathway	REACTOME_P38MAPK_EVENTS	MAPK14 MAPK11 MAPK13	1.17e-05	13	50	3	M1441
Pathway	WP_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_IN_COLORECTAL_CANCER	COL4A6 MAPK14 PKD1 LRP5 MAPK11 MAPK13	2.12e-05	161	50	6	M39770
Pathway	WP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE	RIF1 MAPK14 MAPK11 MAPK13	2.23e-05	47	50	4	M39518
Pathway	REACTOME_SIGNALLING_TO_RAS	MAPK14 MAPK11 MAPK13	4.59e-05	20	50	3	M12256
Pathway	WP_OSTEOBLAST_DIFFERENTIATION_AND_RELATED_DISEASES	MAPK14 LRP5 PTCH1 MAPK11 MAPK13	5.92e-05	118	50	5	M39852
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_APOPTOSIS	MAPK14 MAPK11 MAPK13	6.17e-05	22	50	3	M39902
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_NFE2L2_NRF2_SURVIVAL_SIGNALING	MAPK14 MAPK11 MAPK13	7.07e-05	23	50	3	M39709
Pathway	WP_LDL_INFLUENCE_ON_CD14_AND_TLR4	MAPK14 MAPK11 MAPK13	7.07e-05	23	50	3	M45556
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST5 GUSB CHST6 EXT2 HS3ST1	7.21e-05	123	50	5	MM14623
Pathway	REACTOME_GLYCOSAMINOGLYCAN_METABOLISM	CHST5 GUSB CHST6 EXT2 HS3ST1	8.09e-05	126	50	5	M695
Pathway	KEGG_MEDICUS_REFERENCE_TLR2_4_MAPK_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	1.03e-04	26	50	3	M47565
Pathway	WP_FGFR3_SIGNALING_IN_CHONDROCYTE_PROLIFERATION_AND_TERMINAL_DIFFERENTIATION	MAPK14 MAPK11 MAPK13	1.16e-04	27	50	3	M39838
Pathway	WP_NANOPARTICLEMEDIATED_ACTIVATION_OF_RECEPTOR_SIGNALING	MAPK14 MAPK11 MAPK13	1.29e-04	28	50	3	M39572
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK14 RPS6KB2 MAPK11 MAPK13	1.49e-04	76	50	4	MM1433
Pathway	BIOCARTA_MAPK_PATHWAY	MAPK14 RPS6KB2 MAPK11 MAPK13	1.91e-04	81	50	4	M13863
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNB_G_RHO_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	2.13e-04	33	50	3	M47550
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	2.13e-04	33	50	3	MM14663
Pathway	REACTOME_SIGNALLING_TO_ERKS	MAPK14 MAPK11 MAPK13	2.33e-04	34	50	3	M13881
Pathway	SIG_CD40PATHWAYMAP	MAPK14 MAPK11 MAPK13	2.33e-04	34	50	3	M12705
Pathway	REACTOME_DISEASES_OF_METABOLISM	GUSB CHST6 SI ALG3 EXT2 ADAMTSL4	2.42e-04	250	50	6	M27554
Pathway	REACTOME_P38MAPK_EVENTS	MAPK14 MAPK11	2.56e-04	7	50	2	MM14672
Pathway	REACTOME_NOD1_2_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	2.76e-04	36	50	3	M1059
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_MAPK_SIGNALING	MAPK14 MAPK11 MAPK13	2.76e-04	36	50	3	M39908
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13 GNRHR	4.44e-04	101	50	4	M1979
Pathway	REACTOME_ACTIVATION_OF_PPARGC1A_PGC_1ALPHA_BY_PHOSPHORYLATION	MAPK14 MAPK11	5.45e-04	10	50	2	M27146
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK14 MAPK11	5.45e-04	10	50	2	MM15135
Pathway	REACTOME_ACTIVATION_OF_THE_AP_1_FAMILY_OF_TRANSCRIPTION_FACTORS	MAPK14 MAPK11	5.45e-04	10	50	2	M13962
Pathway	WP_THERMOGENESIS	MAPK14 RPS6KB2 MAPK11 MAPK13	5.72e-04	108	50	4	M39746
Pathway	REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS	MAPK14 MAPK11 MAPK13	6.10e-04	47	50	3	MM14664
Pathway	WP_PHOTODYNAMIC_THERAPYINDUCED_AP1_SURVIVAL_SIGNALING	MAPK14 MAPK11 MAPK13	7.76e-04	51	50	3	M39438
Pathway	REACTOME_SIGNALLING_TO_RAS	MAPK14 MAPK11	7.95e-04	12	50	2	MM14657
Pathway	KEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS	MAPK14 MAPK11 MAPK13	8.68e-04	53	50	3	M3812
Pathway	WP_IL4_SIGNALING	MAPK14 HRH1 MAPK11	9.17e-04	54	50	3	M39720
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	GUSB EXT2 HS3ST1	9.17e-04	54	50	3	MM14633
Pathway	WP_HYPOXIADEPENDENT_DIFFERENTIATION_OF_MYOBLASTS	MAPK14 HIF1AN	9.38e-04	13	50	2	MM15894
Pathway	REACTOME_NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS	MAPK14 MAPK11 MAPK13	1.02e-03	56	50	3	M1074
Pathway	REACTOME_HEPARAN_SULFATE_HEPARIN_HS_GAG_METABOLISM	GUSB EXT2 HS3ST1	1.07e-03	57	50	3	M692
Pathway	WP_PARKINSONS_DISEASE	MAPK14 MAPK11 MAPK13	1.07e-03	57	50	3	MM15899
Pathway	WP_ANGIOPOIETINLIKE_PROTEIN_8_REGULATORY_PATHWAY	MAPK14 RPS6KB2 MAPK11 MAPK13	1.21e-03	132	50	4	M39338
Pathway	WP_NOVEL_INTRACELLULAR_COMPONENTS_OF_RIGILIKE_RECEPTOR_PATHWAY	MAPK14 MAPK11 MAPK13	1.25e-03	60	50	3	M39583
Pathway	KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	1.37e-03	62	50	3	M15569
Pathway	REACTOME_KSRP_KHSRP_BINDS_AND_DESTABILIZES_MRNA	MAPK14 MAPK11	1.62e-03	17	50	2	M959
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	CHST6 ALG3 EXT2 ADAMTSL4	1.63e-03	143	50	4	M27275
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	MAPK14 MAPK11 MAPK13	1.79e-03	68	50	3	M39456
Pathway	KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION	MAPK14 MAPK11 MAPK13	1.79e-03	68	50	3	M16848
Pathway	KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	2.03e-03	71	50	3	M15913
Pathway	WP_PARKINSONS_DISEASE_PATHWAY	MAPK14 MAPK11 MAPK13	2.03e-03	71	50	3	M39461
Pathway	REACTOME_ERK_MAPK_TARGETS	MAPK14 MAPK11	2.03e-03	19	50	2	MM14780
Pathway	KEGG_LEISHMANIA_INFECTION	MAPK14 MAPK11 MAPK13	2.11e-03	72	50	3	M3126
Pathway	WP_NONGENOMIC_ACTIONS_OF_125_DIHYDROXYVITAMIN_D3	MAPK14 MAPK11 MAPK13	2.37e-03	75	50	3	M39568
Pathway	WP_INSULIN_SIGNALING	MAPK14 RPS6KB2 MAPK11 MAPK13	2.45e-03	160	50	4	MM15956
Pathway	WP_INSULIN_SIGNALING	MAPK14 RPS6KB2 MAPK11 MAPK13	2.45e-03	160	50	4	M39482
Pathway	KEGG_VEGF_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	2.46e-03	76	50	3	M1749
Pathway	PID_P38_MK2_PATHWAY	MAPK14 MAPK11	2.48e-03	21	50	2	M199
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	CHST5 GUSB CHST6 EXT2 HS3ST1	2.65e-03	271	50	5	MM15406
Pathway	WP_REGULATORY_CIRCUITS_OF_STAT3_SIGNALING	MAPK14 MAPK11 MAPK13	2.65e-03	78	50	3	M39824
Pathway	REACTOME_ERK_MAPK_TARGETS	MAPK14 MAPK11	2.72e-03	22	50	2	M13408
Pathway	BIOCARTA_NTHI_PATHWAY	MAPK14 MAPK11	2.72e-03	22	50	2	MM1443
Pathway	PID_P73PATHWAY	MAPK14 MAPK11 GRAMD4	2.75e-03	79	50	3	M19
Pathway	KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	2.75e-03	79	50	3	M11816
Pathway	BIOCARTA_NTHI_PATHWAY	MAPK14 MAPK11	2.97e-03	23	50	2	M2821
Pathway	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	MAPK14 MAPK11	2.97e-03	23	50	2	M17243
Pathway	WP_PHYSIOLOGICAL_AND_PATHOLOGICAL_HYPERTROPHY_OF_THE_HEART	MAPK14 MAPK11	3.24e-03	24	50	2	M39576
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	MAPK14 MAPK11	3.24e-03	24	50	2	M27553
Pathway	REACTOME_ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION	MAPK14 MAPK11	3.24e-03	24	50	2	MM15133
Pathway	REACTOME_MYOGENESIS	MAPK14 MAPK11	3.24e-03	24	50	2	MM15174
Pathway	KEGG_PROGESTERONE_MEDIATED_OOCYTE_MATURATION	MAPK14 MAPK11 MAPK13	3.38e-03	85	50	3	M3578
Pathway	REACTOME_METABOLISM_OF_CARBOHYDRATES	CHST5 GUSB CHST6 EXT2 HS3ST1	3.44e-03	288	50	5	M16864
Pathway	REACTOME_RHO_GTPASES_ACTIVATE_NADPH_OXIDASES	MAPK14 MAPK11	3.51e-03	25	50	2	MM15269
Pathway	PID_LYMPH_ANGIOGENESIS_PATHWAY	MAPK14 MAPK11	3.51e-03	25	50	2	M274
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	NRXN3 LRRC4B SYT10	3.61e-03	87	50	3	M27617
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_HEPARAN_SULFATE	EXT2 HS3ST1	3.79e-03	26	50	2	M7330
Pathway	REACTOME_SIGNALLING_TO_ERKS	MAPK14 MAPK11	3.79e-03	26	50	2	MM14716
Pathway	PID_P38_MKK3_6PATHWAY	MAPK14 MAPK11	3.79e-03	26	50	2	M20
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	GBA2 CERS4	4.09e-03	27	50	2	M39863
Pathway	WP_FOLLICLE_STIMULATING_HORMONE_FSH_SIGNALING	MAPK14 RPS6KB2	4.09e-03	27	50	2	M39609
Pathway	WP_HIPPOCAMPAL_SYNAPTOGENESIS_AND_NEUROGENESIS	MAPK14 NRXN3	4.09e-03	27	50	2	M45550
Pathway	REACTOME_NUCLEAR_EVENTS_KINASE_AND_TRANSCRIPTION_FACTOR_ACTIVATION	MAPK14 MAPK11	4.09e-03	27	50	2	MM14779
Pathway	REACTOME_KERATAN_SULFATE_BIOSYNTHESIS	CHST5 CHST6	4.39e-03	28	50	2	M670
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	MAPK14 MAPK11	4.39e-03	28	50	2	MM15132
Pathway	REACTOME_KERATAN_SULFATE_BIOSYNTHESIS	CHST5 CHST6	4.39e-03	28	50	2	MM14798
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	EXT2 HS3ST1	4.71e-03	29	50	2	MM14802
Pathway	REACTOME_MYOGENESIS	MAPK14 MAPK11	4.71e-03	29	50	2	M853
Pathway	REACTOME_METABOLISM_OF_LIPIDS	ELOVL4 MOGAT1 MBOAT7 TSPO TM7SF2 GBA2 BDH1 CERS4	4.82e-03	757	50	8	M27451
Pathway	WP_SPHINGOLIPID_PATHWAY	GBA2 CERS4	5.03e-03	30	50	2	M39501
Pathway	PID_P38_ALPHA_BETA_PATHWAY	MAPK14 MAPK11	5.03e-03	30	50	2	M76
Pathway	REACTOME_HS_GAG_BIOSYNTHESIS	EXT2 HS3ST1	5.37e-03	31	50	2	M685
Pathway	REACTOME_MAPK_TARGETS_NUCLEAR_EVENTS_MEDIATED_BY_MAP_KINASES	MAPK14 MAPK11	5.37e-03	31	50	2	M15195
Pathway	PID_CD40_PATHWAY	MAPK14 MAPK11	5.37e-03	31	50	2	M45
Pathway	KEGG_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY	MAPK14 MAPK11 MAPK13	5.63e-03	102	50	3	M3261
Pathway	WP_HAIR_FOLLICLE_DEVELOPMENT_ORGANOGENESIS_STAGE_2_OF_3	LRP5 PTCH1	5.71e-03	32	50	2	M40041
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	MAPK14 MAPK11 MAPK13	5.79e-03	103	50	3	M39434
Pathway	REACTOME_SIGNALING_BY_VEGF	MAPK14 MAPK11 MAPK13	5.79e-03	103	50	3	MM14752
Pathway	REACTOME_METABOLISM_OF_LIPIDS	MOGAT1 MBOAT7 TSPO TM7SF2 GBA2 BDH1 CERS4	5.93e-03	620	50	7	MM15193
Pathway	PID_NCADHERIN_PATHWAY	DAGLB LRP5	6.07e-03	33	50	2	M266
Pubmed	Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate.	MAPK14 MAPK11 MAPK13	5.94e-09	3	64	3	21336470
Pubmed	Essential role for p38alpha MAPK but not p38gamma MAPK in Igf2 expression and myoblast differentiation.	MAPK14 MAPK11 MAPK13	2.37e-08	4	64	3	20610565
Pubmed	Role for mitogen-activated protein kinase p38 alpha in lung epithelial branching morphogenesis.	MAPK14 MAPK11 MAPK13	2.37e-08	4	64	3	18177852
Pubmed	Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines.	MAPK14 MAPK11 MAPK13	2.37e-08	4	64	3	10066767
Pubmed	Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly.	MAPK14 MAPK11 MAPK13	5.93e-08	5	64	3	15632108
Pubmed	Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.	MAPK14 MAPK11 MAPK13	5.93e-08	5	64	3	17304211
Pubmed	Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer's mice.	MAPK14 MAPK11 MAPK13	1.18e-07	6	64	3	27856911
Pubmed	Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.	MAPK14 MAPK11 MAPK13	1.18e-07	6	64	3	14680475
Pubmed	F-box Protein βTrCP1 Is a Substrate of Extracellular Signal-regulated Kinase 2.	MAPK14 MAPK11 MAPK13	3.31e-07	8	64	3	34703820
Pubmed	Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways.	MAPK14 MAPK11 MAPK13	1.29e-06	12	64	3	12171600
Pubmed	The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1.	MAPK14 MAPK11 MAPK13	1.68e-06	13	64	3	17906618
Pubmed	gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes.	MAPK14 MAPK11 MAPK13	2.13e-06	14	64	3	12239168
Pubmed	PRAK, a novel protein kinase regulated by the p38 MAP kinase.	MAPK14 MAPK11 MAPK13	2.66e-06	15	64	3	9628874
Pubmed	Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.	MAPK14 MAPK11	3.33e-06	2	64	2	29357353
Pubmed	Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages.	MAPK11 MAPK13	3.33e-06	2	64	2	10201954
Pubmed	Counter-regulation of T cell effector function by differentially activated p38.	MAPK14 MAPK11	3.33e-06	2	64	2	24863062
Pubmed	Structure and polymorphism of two stress-activated protein kinase genes centromeric of the MHC: SAPK2a and SAPK4.	MAPK14 MAPK13	3.33e-06	2	64	2	10727080
Pubmed	Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta).	CHST5 CHST6	3.33e-06	2	64	2	11352640
Pubmed	Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase.	CHST5 CHST6	3.33e-06	2	64	2	16938851
Pubmed	Mapping non-class II H2-linked loci for type 1 diabetes in nonobese diabetic mice.	MAPK14 MAPK13	3.33e-06	2	64	2	15561967
Pubmed	Intrinsically active variants of all human p38 isoforms.	MAPK14 MAPK11	3.33e-06	2	64	2	17241234
Pubmed	p38 (Mapk14/11) occupies a regulatory node governing entry into primitive endoderm differentiation during preimplantation mouse embryo development.	MAPK14 MAPK11	3.33e-06	2	64	2	27605380
Pubmed	p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting.	MAPK14 MAPK11	3.33e-06	2	64	2	19955483
Pubmed	The p38alpha/beta MAPK functions as a molecular switch to activate the quiescent satellite cell.	MAPK14 MAPK11	3.33e-06	2	64	2	15824134
Pubmed	The activation of p38 alpha, and not p38 beta, mitogen-activated protein kinase is required for ischemic preconditioning.	MAPK14 MAPK11	3.33e-06	2	64	2	20188737
Pubmed	Convergence of Igf2 expression and adhesion signalling via RhoA and p38 MAPK enhances myogenic differentiation.	MAPK14 MAPK11	3.33e-06	2	64	2	17105766
Pubmed	p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice.	MAPK14 MAPK11	3.33e-06	2	64	2	24531379
Pubmed	Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase.	MAPK14 MAPK13	3.33e-06	2	64	2	9295308
Pubmed	Mouse embryonic stem cells lacking p38alpha and p38delta can differentiate to endothelial cells, smooth muscle cells, and epithelial cells.	MAPK14 MAPK13	3.33e-06	2	64	2	19539422
Pubmed	p38 Mitogen-activated protein kinase regulates chamber-specific perinatal growth in heart.	MAPK14 MAPK11	3.33e-06	2	64	2	32573492
Pubmed	Effect of p38 MAP kinases on contractility and ischemic injury in intact heart.	MAPK14 MAPK11	3.33e-06	2	64	2	19706373
Pubmed	p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.	MAPK14 MAPK13	3.33e-06	2	64	2	29979672
Pubmed	Roles of p38α and p38β mitogen‑activated protein kinase isoforms in human malignant melanoma A375 cells.	MAPK14 MAPK11	3.33e-06	2	64	2	31661126
Pubmed	Electron tomography reveals multiple self-association of chondroitin sulphate/dermatan sulphate proteoglycans in Chst5-null mouse corneas.	CHST5 CHST6	3.33e-06	2	64	2	21440637
Pubmed	p38α and p38β mitogen-activated protein kinases determine cholinergic transdifferentiation of sympathetic neurons.	MAPK14 MAPK11	3.33e-06	2	64	2	21865449
Pubmed	The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation.	MAPK14 MAPK13	3.33e-06	2	64	2	29287762
Pubmed	Interferon-alpha induces the growth inhibition of human T-cell leukaemia line Jurkat through p38alpha and p38beta.	MAPK14 MAPK11	3.33e-06	2	64	2	20053787
Pubmed	Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.	CHST5 CHST6	3.33e-06	2	64	2	11017086
Pubmed	Systematic protein-protein interaction mapping for clinically relevant human GPCRs.	NRXN3 SLC41A3 MBOAT7 TMEM94 PKD1 TM7SF2 HRH1 SI GNRHR	5.10e-06	697	64	9	28298427
Pubmed	p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation.	MAPK14 MAPK11 MAPK13	8.93e-06	22	64	3	16751104
Pubmed	The protein tyrosine kinase SYK regulates the alternative p38 activation in liver during acute liver inflammation.	MAPK14 MAPK11	9.99e-06	3	64	2	31780731
Pubmed	Preferential expression of sialyl 6'-sulfo N-acetyllactosamine-capped O-glycans on high endothelial venules in human peripheral lymph nodes.	CHST5 CHST6	9.99e-06	3	64	2	31148596
Pubmed	Hepatocyte growth factor and p38 promote osteogenic differentiation of human mesenchymal stem cells.	MAPK14 MAPK11	9.99e-06	3	64	2	24673557
Pubmed	Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.	CHST5 CHST6	9.99e-06	3	64	2	12218059
Pubmed	The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.	MAPK14 MAPK11	9.99e-06	3	64	2	17210568
Pubmed	Cholesterol depletion upregulates involucrin expression in epidermal keratinocytes through activation of p38.	MAPK14 MAPK11	9.99e-06	3	64	2	15304097
Pubmed	Astrocytic p38α MAPK drives NMDA receptor-dependent long-term depression and modulates long-term memory.	MAPK14 MAPK11	9.99e-06	3	64	2	31273206
Pubmed	TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.	MAPK14 MAPK11	9.99e-06	3	64	2	22522454
Pubmed	The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.	MAPK14 MAPK11	9.99e-06	3	64	2	12384504
Pubmed	Histamine receptor H1 is required for TCR-mediated p38 MAPK activation and optimal IFN-gamma production in mice.	MAPK14 HRH1	9.99e-06	3	64	2	17965772
Pubmed	Chemical genetics define the roles of p38alpha and p38beta in acute and chronic inflammation.	MAPK14 MAPK11	9.99e-06	3	64	2	17855341
Pubmed	Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation.	MAPK14 MAPK11	9.99e-06	3	64	2	21715315
Pubmed	Promyelocytic leukemia is a direct inhibitor of SAPK2/p38 mitogen-activated protein kinase.	MAPK14 MAPK11	9.99e-06	3	64	2	15273249
Pubmed	Efficient adult skeletal muscle regeneration in mice deficient in p38beta, p38gamma and p38delta MAP kinases.	MAPK11 MAPK13	9.99e-06	3	64	2	18641461
Pubmed	Involvement of the p38 mitogen-activated protein kinase alpha, beta, and gamma isoforms in myogenic differentiation.	MAPK14 MAPK11	9.99e-06	3	64	2	18256287
Pubmed	Nerve growth factor inhibits apoptosis in memory B lymphocytes via inactivation of p38 MAPK, prevention of Bcl-2 phosphorylation, and cytochrome c release.	MAPK14 MAPK11	9.99e-06	3	64	2	11495898
Pubmed	Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.	MAPK11 MAPK13	9.99e-06	3	64	2	26666822
Pubmed	Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin.	MAPK14 MAPK11	9.99e-06	3	64	2	20162623
Pubmed	Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I.	MAPK14 MAPK13	9.99e-06	3	64	2	18559936
Pubmed	p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts.	MAPK14 MAPK11	9.99e-06	3	64	2	16364914
Pubmed	Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.	CHST5 CHST6	9.99e-06	3	64	2	11278593
Pubmed	Phosphorylation of SNX27 by MAPK11/14 links cellular stress-signaling pathways with endocytic recycling.	MAPK14 MAPK11	9.99e-06	3	64	2	33605979
Pubmed	Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases.	MAPK11 MAPK13	9.99e-06	3	64	2	9218798
Pubmed	Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.	CHST5 CHST6	9.99e-06	3	64	2	10491328
Pubmed	Protein arginine methyltransferase 1 interacts with and activates p38α to facilitate erythroid differentiation.	MAPK14 MAPK11	9.99e-06	3	64	2	23483889
Pubmed	Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.	MAPK14 MAPK11	2.00e-05	4	64	2	15708845
Pubmed	Transforming growth factor-beta1 stimulates vascular endothelial growth factor 164 via mitogen-activated protein kinase kinase 3-p38alpha and p38delta mitogen-activated protein kinase-dependent pathway in murine mesangial cells.	MAPK14 MAPK13	2.00e-05	4	64	2	15143069
Pubmed	Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.	MAPK14 MAPK11	2.00e-05	4	64	2	10330143
Pubmed	Regulation of PTEN activity by p38δ-PKD1 signaling in neutrophils confers inflammatory responses in the lung.	PKD1 MAPK13	2.00e-05	4	64	2	23129748
Pubmed	p38 kinase regulates epidermal growth factor receptor downregulation and cellular migration.	MAPK14 MAPK11	2.00e-05	4	64	2	17139251
Pubmed	MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.	MAPK14 MAPK13	2.00e-05	4	64	2	18367666
Pubmed	p38gamma mitogen-activated protein kinase is a key regulator in skeletal muscle metabolic adaptation in mice.	MAPK14 MAPK11	2.00e-05	4	64	2	19936205
Pubmed	Cutting edge: IL-4 induces suppressor of cytokine signaling-3 expression in B cells by a mechanism dependent on activation of p38 MAPK.	MAPK14 MAPK11	2.00e-05	4	64	2	15728454
Pubmed	Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation.	MAPK14 MAPK11	2.00e-05	4	64	2	20188673
Pubmed	Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for activation of p38alpha and p38delta MAPK isoforms by TGF-beta 1 in murine mesangial cells.	MAPK14 MAPK13	2.00e-05	4	64	2	12374793
Pubmed	TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling.	MAPK14 MAPK11	2.00e-05	4	64	2	24161934
Pubmed	Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction.	MAPK14 MAPK11	2.00e-05	4	64	2	28011639
Pubmed	Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression.	MAPK14 MAPK11	2.00e-05	4	64	2	26479921
Pubmed	Signaling mechanism of tumor cell-induced up-regulation of E3 ubiquitin ligase UBR2.	MAPK14 MAPK11	2.00e-05	4	64	2	23568773
Pubmed	Differential induction of interleukin-10 in monocytes by HIV-1 clade B and clade C Tat proteins.	MAPK14 MAPK11	2.00e-05	4	64	2	20378550
Pubmed	The stress-activated protein kinases p38α/β and JNK1/2 cooperate with Chk1 to inhibit mitotic entry upon DNA replication arrest.	MAPK14 MAPK11	3.32e-05	5	64	2	22935704
Pubmed	p27 suppresses cyclooxygenase-2 expression by inhibiting p38β and p38δ-mediated CREB phosphorylation upon arsenite exposure.	MAPK11 MAPK13	3.32e-05	5	64	2	23639288
Pubmed	Activation of p38alpha/beta MAPK in myogenesis via binding of the scaffold protein JLP to the cell surface protein Cdo.	MAPK14 MAPK11	3.32e-05	5	64	2	17074887
Pubmed	Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles.	MAPK11 MAPK13	3.32e-05	5	64	2	9207191
Pubmed	A new p38 MAP kinase-regulated transcriptional coactivator that stimulates p53-dependent apoptosis.	MAPK14 MAPK11	3.32e-05	5	64	2	17380123
Pubmed	p38α MAPK proximity assay reveals a regulatory mechanism of alternative splicing in cardiomyocytes.	MAPK14 MAPK11	3.32e-05	5	64	2	31505169
Pubmed	GlcNAc6ST3 is a keratan sulfate sulfotransferase for the protein-tyrosine phosphatase PTPRZ in the adult brain.	CHST5 CHST6	3.32e-05	5	64	2	30867513
Pubmed	ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome.	MAPK14 MAPK11	3.32e-05	5	64	2	35857590
Pubmed	Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 mitogen-activated protein kinase-dependent pathway.	MAPK14 MAPK11	3.32e-05	5	64	2	12612065
Pubmed	Peripheral Deletion of CD8 T Cells Requires p38 MAPK in Cross-Presenting Dendritic Cells.	MAPK14 MAPK11	3.32e-05	5	64	2	28864471
Pubmed	RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.	MAPK14 RPS6KB2	3.32e-05	5	64	2	9465032
Pubmed	MKK6 deficiency promotes cardiac dysfunction through MKK3-p38γ/δ-mTOR hyperactivation.	MAPK14 MAPK13	3.32e-05	5	64	2	35971771
Pubmed	Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice.	MAPK14 MAPK11 MAPK13	3.41e-05	34	64	3	23300479
Pubmed	Piwil2 inhibits keratin 8 degradation through promoting p38-induced phosphorylation to resist Fas-mediated apoptosis.	MAPK14 PIWIL2	4.98e-05	6	64	2	25113562
Pubmed	Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases.	MAPK14 MAPK13	4.98e-05	6	64	2	22447027
Pubmed	Up-regulation of galectin-9 induces cell migration in human dendritic cells infected with dengue virus.	MAPK14 MAPK11	4.98e-05	6	64	2	25754930
Pubmed	Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases.	MAPK14 MAPK11	4.98e-05	6	64	2	15735648
Pubmed	Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice.	GUSB SI	4.98e-05	6	64	2	10383162
Pubmed	Signaling via the kinase p38α programs dendritic cells to drive TH17 differentiation and autoimmune inflammation.	MAPK14 MAPK11	4.98e-05	6	64	2	22231518
Pubmed	Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.	CHST5 CHST6	4.98e-05	6	64	2	17690104
Cytoband	16p13.3	TPSD1 LMF1 PKD1 SEC14L5	3.85e-04	244	64	4	16p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr22q13	ACR TSPO MAPK11 GRAMD4	1.19e-03	330	64	4	chr22q13
Cytoband	22q13.33	ACR MAPK11	1.30e-03	38	64	2	22q13.33
Cytoband	22q13.31	TSPO GRAMD4	1.90e-03	46	64	2	22q13.31
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	TPSD1 LMF1 PKD1 SEC14L5	2.99e-03	426	64	4	chr16p13
GeneFamily	Mitogen-activated protein kinases	MAPK14 MAPK11 MAPK13	3.52e-06	13	43	3	651
GeneFamily	Abhydrolase domain containing	ABHD12B ABHD1 EPHX4	1.87e-05	22	43	3	4
GeneFamily	Sulfotransferases, membrane bound	CHST5 CHST6 HS3ST1	9.20e-05	37	43	3	763
Coexpression	GSE7548_DAY7_VS_DAY28_PCC_IMMUNIZATION_CD4_TCELL_UP	COL4A6 NRXN3 GUSB HRH1 PTCH1 GRAMD4	8.66e-06	200	63	6	M6842
CoexpressionAtlas	e10.5_Nasal_Pit_top-relative-expression-ranked_250	MOGAT1 TM7SF2 ABHD1 SHISAL2A MAPK13 CERS4	1.54e-05	189	60	6	Facebase_ST1_e10.5_Nasal_Pit_250
Drug	tolyltriazole	MAPK14 TSPO MAPK11 MAPK13	8.48e-10	6	64	4	CID000025902
Drug	Ac2-26	MAPK14 MAPK11 MAPK13	8.46e-08	4	64	3	CID000568638
Drug	NSC-68458	MAPK14 MAPK11 MAPK13	8.46e-08	4	64	3	CID000249771
Drug	SD-282	MAPK14 MAPK11 MAPK13 GNRHR	1.01e-07	16	64	4	CID014973220
Drug	tyrphostin B46	MAPK14 TSPO MAPK11 MAPK13	4.83e-07	23	64	4	CID000002058
Drug	Cp-38	MAPK14 MAPK11 MAPK13	7.35e-07	7	64	3	CID006918286
Drug	satratoxin H	MAPK14 MAPK11 MAPK13	7.35e-07	7	64	3	CID000434380
Drug	2,2',4,6-tetrachlorobiphenyl	MAPK14 MAPK11 MAPK13	7.35e-07	7	64	3	CID000044163
Drug	CID6325568	MAPK14 MAPK11 MAPK13	7.35e-07	7	64	3	CID006325568
Drug	Z-D-CH2DCB	MAPK14 MAPK11 MAPK13	1.17e-06	8	64	3	CID009911778
Drug	ML3403	MAPK14 MAPK11 MAPK13	1.17e-06	8	64	3	CID006419739
Drug	SB220025	MAPK14 ABHD1 MAPK11 MAPK13	1.28e-06	29	64	4	CID000005164
Drug	1xp1	MAPK14 ACR TSPO HRH1 PTK7	1.57e-06	70	64	5	CID000449205
Drug	SC68376	MAPK14 MAPK11 MAPK13	1.76e-06	9	64	3	CID000005174
Drug	AC1NOLIT	MAPK14 MAPK11 MAPK13	2.51e-06	10	64	3	CID005090286
Drug	nemorosone	MAPK14 MAPK11 MAPK13	3.44e-06	11	64	3	CID000637105
Drug	sesamolin	MAPK14 MAPK11 MAPK13	4.58e-06	12	64	3	CID000101746
Drug	Substance P	TPSD1 CHRNA6 THOP1 MAPK14 HRH1 MAPK11 MAPK13 PTK7	5.19e-06	343	64	8	CID000036511
Drug	AGEPC	TPSD1 MAPK14 GUSB TSPO TM7SF2 HRH1 MAPK11 MAPK13	6.82e-06	356	64	8	CID000461545
Drug	SB-242235	MAPK14 MAPK11 MAPK13	7.54e-06	14	64	3	CID009863367
Drug	SB202474	MAPK14 MAPK11 MAPK13	7.54e-06	14	64	3	CID000005162
Drug	CPI-1189	MAPK14 MAPK11 MAPK13	7.54e-06	14	64	3	CID000151118
Drug	poly-N-acetyllactosamine	CHST5 CHST6	7.78e-06	2	64	2	ctd:C037199
Drug	adaphostin	MAPK14 RPS6KB2 MAPK11 MAPK13	8.48e-06	46	64	4	CID000387042
Drug	celiprolol	MAPK14 SLC12A4 MAPK11 MAPK13	9.25e-06	47	64	4	CID000002663
Drug	MMP-2 Inhibitor I	MAPK14 MAPK11 MAPK13	9.41e-06	15	64	3	CID000004220
Drug	epicholesterol	DAGLB CHRNA6 MAPK14 SLC12A4 TSPO TM7SF2 LRP5 PTCH1 MAPK11 MAPK13	1.05e-05	636	64	10	CID000000304
Drug	benzenesulfonyl fluoride	MAPK14 SLC12A4 MAPK11 MAPK13	1.09e-05	49	64	4	CID000067779
Drug	SB 239063	MAPK14 MAPK11 MAPK13	1.16e-05	16	64	3	CID000005166
Drug	AMP 579	MAPK14 MAPK11 MAPK13	1.16e-05	16	64	3	CID006918429
Drug	Ambotz208527-57-5	MAPK14 MAPK11 MAPK13	1.40e-05	17	64	3	CID010258704
Drug	dracorhodin	MAPK14 MAPK11 MAPK13	1.40e-05	17	64	3	CID000069509
Drug	kazinol B	MAPK14 MAPK11 MAPK13	1.40e-05	17	64	3	CID000480869
Drug	SIN-1 chloride	MAPK14 GUSB MAPK11 MAPK13	1.50e-05	53	64	4	CID000065388
Drug	AC1L9HFF	MAPK14 RPS6KB2 MAPK11 MAPK13	1.74e-05	55	64	4	CID000445102
Drug	hydroxybutyrate	MAPK14 TSPO MAPK11 MAPK13 BDH1	1.81e-05	115	64	5	CID000010413
Drug	Dihydroergotamine tartrate [5989-77-5]; Up 200; 3uM; PC3; HT_HG-U133A	CHST5 NRXN3 PTCH1 HS3ST1 CERS4 SEC14L5	1.92e-05	197	64	6	4502_UP
Drug	Tubocurarine chloride pentahydrate (+) [6989-98-6]; Down 200; 5.2uM; PC3; HT_HG-U133A	ELOVL4 MAPK14 TM7SF2 CUL9 HIF1AN GTF3C5	2.03e-05	199	64	6	6351_DN
Drug	S)-bromoenol lactone	DAGLB TPSD1 MAPK14 MAPK11 MAPK13	2.14e-05	119	64	5	CID000002445
Drug	6-((2-(4-imidazolyl)ethyl)amino)heptanoic acid 4-toluidide	GUSB HRH1	2.33e-05	3	64	2	ctd:C081972
Drug	phloroglucinaldehyde	GUSB GBA2	2.33e-05	3	64	2	CID000068099
Drug	virgaureasaponin	GUSB GBA2	2.33e-05	3	64	2	CID006324777
Drug	N-nitroso-2-acetylaminofluorene	TSPO HCCS	2.33e-05	3	64	2	CID000107997
Drug	compound 9b	MAPK14 MAPK11 MAPK13	2.33e-05	20	64	3	CID000207510
Drug	n-sulfo-2-aminotricarballylate	MAPK14 MAPK11 MAPK13	2.33e-05	20	64	3	CID000135808
Drug	aniline mustard	RIF1 GUSB LRP5	2.33e-05	20	64	3	CID000011108
Drug	1-acetyl-sn-glycero-3-phosphocholine	DAGLB MAPK14 SLC12A4 MBOAT7 GUSB MAPK11 MAPK13	2.34e-05	305	64	7	CID005311264
Drug	lecithin	DAGLB MOGAT1 SLC12A4 MBOAT7 GUSB RBP5 BDH1	2.34e-05	305	64	7	CID010425705
Drug	2-ketobenzothiazole 23	TPSD1 MAPK14 MAPK11 MAPK13	2.46e-05	60	64	4	CID003348131
Drug	Clorocruoro Hem	CHRNA6 MAPK14 CUL9 MAPK11 MAPK13	2.51e-05	123	64	5	CID003518809
Drug	L0168	MAPK14 MAPK11 MAPK13	2.72e-05	21	64	3	CID000445856
Drug	propranolol	DAGLB CHRNA6 SLC12A4 PKD1 TSPO HRH1 HCCS PTK7	2.84e-05	434	64	8	CID000004946
Drug	Ro 31-8220	DAGLB MAPK14 MBOAT7 RPS6KB2 HRH1 MAPK11 MAPK13	3.24e-05	321	64	7	CID000005083
Drug	AC1Q5U59	MAPK14 MBOAT7 MAPK11 MAPK13	4.04e-05	68	64	4	CID000005441
Drug	SKF86002	MAPK14 MAPK11 MAPK13	4.11e-05	24	64	3	CID000005228
Drug	ethyl acetate	MAPK14 GUSB ACR MAPK11 MAPK13	4.20e-05	137	64	5	CID000008857
Drug	R59949	DAGLB MAPK14 MAPK11 MAPK13	4.53e-05	70	64	4	CID000657356
Drug	5-hydroxy-2-nitrobenzaldehyde	GUSB GBA2	4.65e-05	4	64	2	CID000039211
Drug	4-nitroso-m-cresol	GUSB GBA2	4.65e-05	4	64	2	CID000011981
Drug	4'-O-(beta-D-glucopyranosyl)-D-pantothenic acid	GUSB GBA2	4.65e-05	4	64	2	CID003082306
Drug	VX-745	MAPK14 MAPK11 MAPK13	4.66e-05	25	64	3	CID003038525
Drug	GF109203X	DAGLB MAPK14 RPS6KB2 HRH1 MAPK11 MAPK13 GNRHR	4.75e-05	341	64	7	CID000002396
Drug	CAS 83919-23-7	TPSD1 MAPK14 MAPK11	5.26e-05	26	64	3	CID000004240
Drug	AC1NSK9Q	MAPK14 MAPK11 MAPK13	5.26e-05	26	64	3	CID005311233
Drug	H S Q	CHST5 GUSB CHST6 ALG3 EXT2 GBA2 ANO3	5.70e-05	351	64	7	CID000000897
Drug	Glycan	MAPK14 SI MAPK11 MAPK13 GBA2	6.07e-05	148	64	5	CID000000871
Drug	AC1L1DDL	TPSD1 MBOAT7 RPS6KB2 PTK7	7.28e-05	79	64	4	CID000002304
Drug	methylazoxymethyl-beta-D-glucosiduronic acid	GUSB GBA2	7.74e-05	5	64	2	CID000149476
Drug	Keratan Sulfate	CHST5 CHST6	7.74e-05	5	64	2	ctd:D007632
Drug	AC1L8VCN	GUSB GBA2	7.74e-05	5	64	2	CID000408702
Drug	AC1Q5THZ	DAGLB TPSD1 THOP1 GUSB ACR HRH1 ABHD1 GNRHR	7.91e-05	502	64	8	CID000001959
Drug	L001226	MAPK14 MAPK11 MAPK13	8.15e-05	30	64	3	CID004373102
Drug	CGP57380	MAPK14 MAPK11 MAPK13	9.00e-05	31	64	3	CID011644425
Drug	4-ethylphenol	MAPK14 MAPK11 MAPK13	9.00e-05	31	64	3	CID000031242
Drug	valproate	MAPK14 RPS6KB2 PKD1 TSPO PTCH1 MAPK11 MAPK13	9.51e-05	381	64	7	CID000003121
Drug	halofuginone lactate	COL4A6 MAPK14 MAPK11 MAPK13	9.69e-05	85	64	4	CID000062891
Drug	K00039	MAPK14 MAPK11 MAPK13	9.91e-05	32	64	3	CID009549277
Drug	malolactomycin D	MAPK14 MAPK11 MAPK13	9.91e-05	32	64	3	CID006449115
Drug	lapatinib	MAPK14 RPS6KB2 MAPK11 MAPK13	1.01e-04	86	64	4	CID000208908
Drug	AC1L1GZB	MAPK14 RPS6KB2 HRH1 MAPK11 MAPK13	1.07e-04	167	64	5	CID000003908
Drug	7-OHIQ	GUSB GBA2	1.16e-04	6	64	2	CID000115222
Drug	4'-O-(beta-D-glucopyranosyl)-D-hopantenic acid	GUSB GBA2	1.16e-04	6	64	2	CID000129183
Drug	X1207	GUSB GBA2	1.16e-04	6	64	2	CID000084718
Drug	AMPK inhibitor	MAPK14 RPS6KB2 MAPK11 MAPK13	1.16e-04	89	64	4	CID011524144
Drug	temazepam	GUSB TSPO TST	1.19e-04	34	64	3	CID000005391
Drug	AC1NSKHR	MAPK14 MAPK11 MAPK13	1.19e-04	34	64	3	CID005311362
Drug	Leupeptin hydrochloride	TPSD1 THOP1 GUSB ACR SI PTK7	1.25e-04	276	64	6	CID000003910
Drug	AC1L1KQK	MAPK14 MAPK11 MAPK13	1.42e-04	36	64	3	CID000005612
Drug	pyridinyl imidazole	MAPK14 MAPK11 MAPK13	1.42e-04	36	64	3	CID000005171
Drug	1kkq	MAPK14 MAPK11 MAPK13	1.42e-04	36	64	3	CID000446738
Drug	Caffeic Acid-13C3	MAPK14 GUSB MAPK11 MAPK13	1.49e-04	95	64	4	CID000002518
Drug	NSC342435	MAPK14 MAPK11 MAPK13	1.54e-04	37	64	3	CID000334935
Drug	chloroquine	MAPK14 GUSB HRH1 MAPK11 MAPK13 GBA2	1.58e-04	288	64	6	CID000002719
Drug	cGpGp	MAPK14 MAPK11 MAPK13	1.67e-04	38	64	3	CID000124875
Drug	MnTMPyP	MAPK14 MAPK11 MAPK13	1.80e-04	39	64	3	CID000004233
Drug	biochanin A	MAPK14 GUSB MAPK11 MAPK13	1.89e-04	101	64	4	CID005280373
Drug	KT5720	THOP1 MAPK14 HRH1 MAPK11 MAPK13	1.92e-04	189	64	5	CID000003844
Drug	lipoic acid	MAPK14 GUSB TST MAPK11 MAPK13	1.92e-04	189	64	5	CID000000864
Drug	Go6983	MAPK14 MAPK11 MAPK13	1.94e-04	40	64	3	CID000003499
Drug	procymidone	MAPK14 MAPK11 MAPK13	1.94e-04	40	64	3	CID000036242
Disease	microphthalmia (is_implicated_in)	LRP5 HCCS	2.60e-05	4	62	2	DOID:10629 (is_implicated_in)
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	PKD1 LRP5	2.60e-05	4	62	2	DOID:898 (is_implicated_in)
Disease	colipase measurement	MAPK14 MAPK13	6.48e-05	6	62	2	EFO_0801485
Disease	polycystic liver disease (implicated_via_orthology)	PKD1 LRP5	9.06e-05	7	62	2	DOID:0050770 (implicated_via_orthology)
Disease	electrodermal activity measurement, skin conductance response amplitude	COL4A6 NRXN3	9.06e-05	7	62	2	EFO_0006866, EFO_0006868
Disease	glycosyl ceramide (d18:1/20:0, d16:1/22:0) measurement	GBA2 CERS4	9.06e-05	7	62	2	EFO_0800551
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 LRP5	3.89e-04	14	62	2	DOID:898 (implicated_via_orthology)
Disease	Schizoaffective disorder-bipolar type	NRXN3 PTCH1	5.11e-04	16	62	2	EFO_0009965
Disease	visual perception measurement	ACR EXT2 BDH1 CFAP46	1.26e-03	223	62	4	EFO_0009700
Disease	blood rubidium measurement	RIF1 HIF1AN	1.37e-03	26	62	2	EFO_0021529
Disease	ocular sarcoidosis	PAMR1 GUSBP1 GRAMD4	1.89e-03	116	62	3	EFO_0010723

Protein segments in the cluster

Peptide	Gene	Start	Entry
WLHKGWQPCMYISFL	C21orf62	156	Q9NYP8
LSVLYHESWLWAPVM	CERS4	151	Q9HA82
PLGWRSLWIGYSFLM	COL4A6	1591	Q14031
MENWTGRPWLYLLLL	ADAMTSL4	1	Q6UY14
YWWLRMQIMTHLPGA	BDH1	321	Q02338
HGAWPWMVSLQIFTY	ACR	51	P10323
HTLPYLLWAMPARWL	ALG3	366	Q92685
YMNAVWHGWAIPLFL	GRAMD4	241	Q6IC98
WWDMVDRNLRYFPHS	ABHD12B	26	Q7Z5M8
MLAARHYWNAWLPLL	CFAP46	1031	Q8IYW2
WMGYELPFDRHDWII	HCCS	201	P53701
LWAPYRPVVWHGMAM	DNHD1	3846	Q96M86
RWGMWYKHQPLDLIR	ANO3	371	Q9BYT9
MWLYFDWHTPERGGR	MOGAT1	56	Q96PD6
RWYRAPEIMLNWMHY	MAPK11	186	Q15759
LYIPMYWWHHIESLL	HIF1AN	271	Q9NWT6
CPFPKWMHWALIAYA	ELOVL4	241	Q9GZR5
MLLLHGFPEFWYSWR	EPHX4	96	Q8IUS5
RWYRAPEIMLNWMHY	MAPK14	186	Q16539
IALDPAHGYMYWTDW	LRP5	156	O75197
MGLPNQWARYLRWDA	NRXN3	31	Q9Y4C0
RWYRAPEVILSWMHY	MAPK13	186	O15264
AWTMLLSAYWHGLHP	MBOAT7	346	Q96N66
WHNLSYMKCSWLPGR	IL13RA1	136	P78552
GWWGMVRHPNYLGDL	TM7SF2	341	O76062
LRHIWNDYKLRWDPM	CHRNA6	86	Q15825
VSNHWWYSMLILPPL	KDM1B	196	Q8NB78
LGIWYWFDPEMLNRL	GNRHR	286	P30968
GMGLRYLQWWYRKTH	GBA2	116	Q9HCG7
LWWIGILTLYLMHRG	DAGLB	31	Q8NCG7
SLWWPYLMHERPAYL	GUSB	286	P08236
TYWVHWHMLEILGPE	CUL9	426	Q8IWT3
FLWVIPILGWNHFMQ	HRH1	156	P35367
NLWWPYLMHEHPASL	GUSBP1	61	Q15486
RWPGVYLLQWQMHSP	SEC14L5	606	O43304
RMSWPHGALLFLWLF	LRRC4B	16	Q9NT99
EELWPWMAHVLLPYV	PKD1	3721	P98161
AFVLWCDWRLHTPMY	OR11H12	61	B2RN74
PRWHLMGLVSWSYDK	PAMR1	681	Q6UXH9
GWYLSQMPFSWPHQL	HS3ST1	101	O14792
GWRHWLEGEMLYLEL	RBP5	106	P82980
WQVSLRVRGPYWMHF	TPSD1	51	Q9BZJ3
PFFRHMNWDDLLAWR	RPS6KB2	326	Q9UBS0
QRLTFKLCHMYWNWP	PIWIL2	921	Q8TC59
VWWYLLMRLGPHLPA	RIF1	341	Q5UIP0
PKMWLHYFRDWLQGL	PTCH1	841	Q13635
PYEHSYMWWLSIGAL	SHISAL2A	51	Q6UWV7
SWAGMLLDYFQHWPV	SLC41A3	81	Q96GZ6
AMPAYWNLGFQLSRW	SI	346	P14410
MRHNSVVLGWPYGWR	SLC12A4	786	Q9UP95
FLEGLLPWQHWYMSR	ABHD1	361	Q96SE0
LPWQHWYMSRLLHQY	ABHD1	366	Q96SE0
PDVFYLMEPAWHVWT	CHST5	86	Q9GZS9
VFYLMEPAWHVWTTL	CHST6	66	Q9GZX3
IGNFFHPLFLWMKWR	TAS2R7	111	Q9NYW3
PWLMVSAAHRLYWPH	nan	281	Q6ZTK2
HMPFAPSWSLHWAYR	TMEM94	156	Q12767
YPGRLHLWDHEMNKW	EXT2	566	Q93063
IPVYVFFHLWTWMGI	PIGY	51	Q3MUY2
WNEMLAYHRKPITHW	SYT10	481	Q6XYQ8
MITGPWRSLWIRFGY	GTF3C5	291	Q9Y5Q8
GEHLGSFYAPRVWWM	TST	101	Q16762
WVWEQEPLLRMSRHY	THOP1	511	P52888
YHFRQAWVPLRWMSP	PTK7	961	Q13308
HWVLGPVWGTLYSAM	TSPO	46	P30536
SHGMKLERYIWDDPW	ZNF606	156	Q8WXB4
SPYHYRLDWLMWFAA	LMF1	456	Q96S06