Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of circadian rhythm	RORB RORC GNAQ MTOR KDM5C	9.86e-06	135	44	5	GO:0042752
GeneOntologyBiologicalProcess	circadian rhythm	DPYD RORB RORC GNAQ MTOR KDM5C	1.37e-05	248	44	6	GO:0007623
Domain	ROR_rcpt	RORB RORC	1.86e-05	3	47	2	IPR003079
Domain	-	MYO18A NWD1 NOD1 GNAQ RFC3 ATAD1 ARL11 DNAH1	4.93e-04	746	47	8	3.40.50.300
Domain	-	ARID1B KDM5C	6.37e-04	15	47	2	1.10.150.60
Domain	BRIGHT	ARID1B KDM5C	6.37e-04	15	47	2	SM00501
Domain	ARID_dom	ARID1B KDM5C	6.37e-04	15	47	2	IPR001606
Domain	ARID	ARID1B KDM5C	6.37e-04	15	47	2	PS51011
Domain	ARID	ARID1B KDM5C	6.37e-04	15	47	2	PF01388
Domain	P-loop_NTPase	MYO18A NWD1 NOD1 GNAQ RFC3 ATAD1 ARL11 DNAH1	1.14e-03	848	47	8	IPR027417
Domain	zf-C4	RORB RORC	5.98e-03	46	47	2	PF00105
Domain	Znf_hrmn_rcpt	RORB RORC	5.98e-03	46	47	2	IPR001628
Domain	Nuclear_hrmn_rcpt	RORB RORC	5.98e-03	46	47	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	RORB RORC	5.98e-03	46	47	2	PS51030
Domain	NUCLEAR_REC_DBD_1	RORB RORC	5.98e-03	46	47	2	PS00031
Domain	ZnF_C4	RORB RORC	5.98e-03	46	47	2	SM00399
Domain	HOLI	RORB RORC	6.49e-03	48	47	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	RORB RORC	6.49e-03	48	47	2	IPR000536
Domain	Hormone_recep	RORB RORC	6.49e-03	48	47	2	PF00104
Domain	AAA	RFC3 ATAD1	7.59e-03	52	47	2	PF00004
Domain	ATPase_AAA_core	RFC3 ATAD1	8.16e-03	54	47	2	IPR003959
Domain	Znf_NHR/GATA	RORB RORC	9.37e-03	58	47	2	IPR013088
Pubmed	Basal activation of p70S6K results in adipose-specific insulin resistance in protein-tyrosine phosphatase 1B -/- mice.	PTPN1 MTOR	1.87e-06	2	48	2	17664276
Pubmed	Regulation of growth hormone induced JAK2 and mTOR signalling by hepatic protein tyrosine phosphatase 1B.	PTPN1 MTOR	5.59e-06	3	48	2	24948418
Pubmed	The mTOR and PP2A Pathways Regulate PHD2 Phosphorylation to Fine-Tune HIF1α Levels and Colorectal Cancer Cell Survival under Hypoxia.	MTOR EGLN1	5.59e-06	3	48	2	28199842
Pubmed	SPOP Mutation Drives Prostate Tumorigenesis In Vivo through Coordinate Regulation of PI3K/mTOR and AR Signaling.	SPOP MTOR	1.12e-05	4	48	2	28292441
Pubmed	Immunohistochemical characterization of the orphan nuclear receptor ROR alpha in the mouse nervous system.	RORB RORC	2.79e-05	6	48	2	14966198
Pubmed	TBR1 regulates autism risk genes in the developing neocortex.	ARID1B ANK2	6.67e-05	9	48	2	27325115
Pubmed	Thalamocortical axons regulate neurogenesis and laminar fates in the early sensory cortex.	RORB RORC	1.22e-04	12	48	2	35613048
Pubmed	Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.	RTKN MTOR	1.22e-04	12	48	2	15467718
Pubmed	Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.	RORC GFRA3	1.44e-04	13	48	2	22855506
Pubmed	Comparative analysis of apoptosis and inflammation genes of mice and humans.	SPOP NOD1 ANK2	1.88e-04	80	48	3	12819136
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	NOD1 RTKN MTOR ARL11	2.75e-04	227	48	4	26410627
Pubmed	Long QT Syndrome Overview	ANK2 KCNJ5	3.14e-04	19	48	2	20301308
Pubmed	Loss of BAF Complex in Developing Cortex Perturbs Radial Neuronal Migration in a WNT Signaling-Dependent Manner.	RORB ARID1B	3.49e-04	20	48	2	34220450
Pubmed	Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	GREB1L ASXL3 ZNF451	3.85e-04	102	48	3	11214970
Pubmed	Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations.	LIG3 RFC3	5.48e-04	25	48	2	20226869
Pubmed	Polymorphisms in the base excision repair pathway and graft-versus-host disease.	LIG3 RFC3	6.40e-04	27	48	2	20574454
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	MYO18A MTOR	7.92e-04	30	48	2	28077597
Pubmed	Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.	LIG3 SPOP RFC3 GFRA3	1.01e-03	321	48	4	32098917
Cytoband	7q31.31	TSPAN12 CPED1	1.60e-05	6	48	2	7q31.31
Cytoband	1p34.1	RNF220 ZSWIM5	1.65e-03	57	48	2	1p34.1
GeneFamily	AT-rich interaction domain containing	ARID1B KDM5C	3.55e-04	15	34	2	418
GeneFamily	Nuclear hormone receptors	RORB RORC	3.82e-03	49	34	2	71
GeneFamily	AAA ATPases	RFC3 ATAD1	4.45e-03	53	34	2	413
Disease	atrial fibrillation (is_implicated_in)	ANK2 KCNJ5	2.23e-04	14	47	2	DOID:0060224 (is_implicated_in)
Disease	Romano-Ward Syndrome	ANK2 KCNJ5	2.94e-04	16	47	2	C0035828
Disease	Neurodevelopmental Disorders	ARID1B ANK2 ASXL3	4.44e-04	93	47	3	C1535926
Disease	nose morphology measurement, mouth morphology measurement	RFC3 TTLL13	5.12e-04	21	47	2	EFO_0007843, EFO_0007955
Disease	diastolic blood pressure, systolic blood pressure	LIG3 RNF220 ARID1B GNAQ ANK2 KCNJ5	6.52e-04	670	47	6	EFO_0006335, EFO_0006336
Disease	Epilepsy	ARID1B ASXL3 KDM5C	7.06e-04	109	47	3	C0014544
Disease	Toxic Encephalitis	MTOR EGLN1	9.81e-04	29	47	2	C0154659
Disease	Neurotoxicity Syndromes	MTOR EGLN1	9.81e-04	29	47	2	C0235032
Disease	Encephalopathy, Toxic	MTOR EGLN1	9.81e-04	29	47	2	C0149504
Disease	hepatocellular carcinoma (is_marker_for)	SPOP RTKN MTOR KDM5C	1.34e-03	301	47	4	DOID:684 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SLRLCDMRAAALCDK	PPP2R2C	246	Q9Y2T4
CSEILLSRMCANKRT	CPED1	1011	A4D0V7
GALREAMRCLKCADA	DPYD	71	Q12882
CRAAKALLAMARVDE	ARID1B	2266	Q8NFD5
SRLCEDKDLCRAAMR	CCNYL1	326	Q8N7R7
ADELELKCSCRLKAM	ASXL3	2206	Q9C0F0
AINCMSLSKCEDRLA	NWD1	1301	Q149M9
IMACCLSEEAKEARR	GNAQ	6	P50148
SCCAKELAEMKREGR	KCNJ5	361	P48544
EARLRCFCMTDDKVD	ANK2	1341	Q01484
SLLKSRSCMCLQARA	ARL11	171	Q969Q4
ERLMCAESNRRDSCK	CFD	191	P00746
CLADTCLLLMDKRKD	PTPN1	226	P18031
ESLRGECEDMLSKCR	MMRN1	586	Q13201
LDLEKSSCCMGLSRV	MYO18A	1156	Q92614
CRMFSCFKESDRLCL	NOD1	236	Q9Y239
CLLREFRKLCAMVAD	LIG3	261	P49916
CQAGKDLRLVSLCME	GREB1L	121	Q9C091
ILACRDMEKCEAAAK	RDH13	66	Q8NBN7
CSDLRMLDSLRDCNK	DNAH1	1291	Q9P2D7
LTDRSMAVRCAVAKC	HEATR5B	186	Q9P2D3
AMLCTLNDKCDRLRK	GFRA3	166	O60609
TQERDSLMCLAKCLE	CEP89	616	Q96ST8
CELCGKMENLLRCSR	EGLN1	21	Q9GZT9
CLLGLSKSDQRAMAC	PKD1L1	2701	Q8TDX9
AEKSCRNLRKALLMC	RFC3	216	P40938
RNLRKALLMCEACRV	RFC3	221	P40938
LVESRCCRDLMEEKF	MTOR	356	P42345
MREGACKLLAACSQR	RTKN	51	Q9BST9
LSRGDRYKCLICMDS	RNF220	506	Q5VTB9
SCLNKCDIALKRDLM	ACTL7A	341	Q9Y615
CALDEAAAALTRMKA	ANKHD1	181	Q8IWZ3
GSDLKEMCRDAALLC	ATAD1	296	Q8NBU5
RCSKRKDAADFAICM	ZNF451	946	Q9Y4E5
AALREMASCITQRKC	TSR2	106	Q969E8
LASCARTLALQCAMK	ZSWIM5	946	Q9P217
VRTRDLCRKSLMCNL	ZNF815P	71	A8K554
KCSDCLMRFGNEREL	ZNF639	461	Q9UID6
RCKECDKSLCMLSRL	ZNF138	111	P52744
CRLQKCLALGMSRDA	RORC	86	P51449
ALERLKVMCEDALCS	SPOP	281	O43791
CRLQKCLALGMSRDA	RORB	76	Q92753
LCGLREKADMLCNSE	TXLNGY	6	Q9BZA5
MAREDSVKCLRCLLY	TSPAN12	1	O95859
KMFCEVDRSLLCLLC	TRIM49B	101	A6NDI0
FNCLLCAEMLGRKED	ZNF438	776	Q7Z4V0
CLDSAAEACDIMVKR	UFL1	641	O94874
LCDAMTLVNLRGCDK	TTLL13	411	A6NNM8
VCRMCSRGDEDDKLL	KDM5C	326	P41229