Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionfour-way junction DNA binding

HMGB1 HMGB2 HMGB3

1.08e-0519463GO:0000400
GeneOntologyMolecularFunctionDNA binding, bending

HMGB1 HMGB2 HMGB3

1.27e-0520463GO:0008301
GeneOntologyMolecularFunctionsupercoiled DNA binding

HMGB1 HMGB2

7.74e-056462GO:0097100
GeneOntologyMolecularFunctionDNA secondary structure binding

HMGB1 HMGB2 HMGB3

1.15e-0441463GO:0000217
GeneOntologyMolecularFunctionRAGE receptor binding

HMGB1 HMGB2

5.35e-0415462GO:0050786
DomainHMG_boxA_CS

HMGB1 HMGB2 HMGB3

1.40e-083463IPR017967
DomainHMG_box_2

HMGB1 HMGB2 HMGB3

1.16e-069463PF09011
DomainHMG_BOX_1

HMGB1 HMGB2 HMGB3

1.66e-0610463PS00353
DomainRII_binding_1

AKAP13 AKAP4

5.91e-055462IPR018459
DomainRII_binding_1

AKAP13 AKAP4

5.91e-055462PF10522
DomainHMG_box

HMGB1 HMGB2 HMGB3

3.00e-0453463PF00505
DomainHMG_BOX_2

HMGB1 HMGB2 HMGB3

3.18e-0454463PS50118
DomainHMG

HMGB1 HMGB2 HMGB3

3.18e-0454463SM00398
Domain-

HMGB1 HMGB2 HMGB3

3.35e-04554631.10.30.10
DomainDH_1

AKAP13 TIAM1 VAV2

5.01e-0463463PS00741
DomainHMG_box_dom

HMGB1 HMGB2 HMGB3

5.49e-0465463IPR009071
DomainRhoGEF

AKAP13 TIAM1 VAV2

6.26e-0468463SM00325
DomainDH_2

AKAP13 TIAM1 VAV2

6.82e-0470463PS50010
DomainRhoGEF

AKAP13 TIAM1 VAV2

6.82e-0470463PF00621
DomainDH-domain

AKAP13 TIAM1 VAV2

7.11e-0471463IPR000219
Domain-

AKAP13 TIAM1 VAV2

7.11e-04714631.20.900.10
DomainHelicase_C

YTHDC2 SMARCA5 DDX10

2.32e-03107463PF00271
DomainHELICc

YTHDC2 SMARCA5 DDX10

2.32e-03107463SM00490
DomainHelicase_C

YTHDC2 SMARCA5 DDX10

2.38e-03108463IPR001650
DomainHELICASE_CTER

YTHDC2 SMARCA5 DDX10

2.45e-03109463PS51194
DomainHELICASE_ATP_BIND_1

YTHDC2 SMARCA5 DDX10

2.45e-03109463PS51192
DomainDEXDc

YTHDC2 SMARCA5 DDX10

2.45e-03109463SM00487
DomainHelicase_ATP-bd

YTHDC2 SMARCA5 DDX10

2.51e-03110463IPR014001
DomainDEAH_ATP_HELICASE

YTHDC2 SMARCA5

3.94e-0338462PS00690
DomainGDS_CDC24_CS

TIAM1 VAV2

4.15e-0339462IPR001331
DomainPDZ

TIAM1 RGS3 AHNAK2

5.04e-03141463PF00595
DomainPDZ

TIAM1 RGS3 AHNAK2

5.77e-03148463SM00228
Domain-

TIAM1 RGS3 AHNAK2

5.99e-031504632.30.42.10
DomainPDZ

TIAM1 RGS3 AHNAK2

6.10e-03151463PS50106
DomainPDZ

TIAM1 RGS3 AHNAK2

6.21e-03152463IPR001478
PathwayBIOCARTA_DNAFRAGMENT_PATHWAY

HMGB1 HMGB2

1.57e-0410272M7239
PathwayREACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK

AKAP13 TIAM1 VAV2

1.90e-0459273M11215
PathwayBIOCARTA_DNAFRAGMENT_PATHWAY

HMGB1 HMGB2

1.92e-0411272MM1349
PathwayREACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION

HMGB1 HMGB2

2.30e-0412272MM14554
PathwayREACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION

HMGB1 HMGB2

2.72e-0413272M1018
PathwayREACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE

AKAP13 TIAM1 VAV2

4.01e-0476273M19832
PathwayREACTOME_G_ALPHA_12_13_SIGNALLING_EVENTS

AKAP13 TIAM1 VAV2

4.67e-0480273M800
PathwayPID_EPHA2_FWD_PATHWAY

TIAM1 VAV2

5.92e-0419272M273
PathwayREACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING

AKAP13 TIAM1 VAV2

8.19e-0497273M9400
Pubmed

Bioinformatics analysis of the prognosis and biological significance of HMGB1, HMGB2, and HMGB3 in gastric cancer.

HMGB1 HMGB2 HMGB3

2.31e-09347331621076
Pubmed

HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.

HMGB1 HMGB2 HMGB3

2.31e-08547319890330
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

PACS1 RRP15 SYNRG YTHDC2 SMARCA5 ITPRID2 UTP18 TCOF1 NIPBL ZRANB2

6.92e-08774471015302935
Pubmed

Cloning and analysis of an HMG gene from the lamprey Lampetra fluviatilis: gene duplication in vertebrate evolution.

HMGB1 HMGB2

1.79e-0624729016958
Pubmed

Anti-high mobility group box 1 and box 2 non-histone chromosomal proteins (HMGB1/HMGB2) antibodies and anti-Saccharomyces cerevisiae antibodies (ASCA): accuracy in differentially diagnosing UC and CD and correlation with inflammatory bowel disease phenotype.

HMGB1 HMGB2

1.79e-06247222644337
Pubmed

Hmg4, a new member of the Hmg1/2 gene family.

HMGB1 HMGB3

1.79e-0624729598312
Pubmed

Association of HMGB1 and HMGB2 genetic polymorphisms with lung cancer chemotherapy response.

HMGB1 HMGB2

1.79e-06247224684392
Pubmed

Properties of Human Embryonic Stem Cells and Their Differentiated Derivatives Depend on Nonhistone DNA-Binding HMGB1 and HMGB2 Proteins.

HMGB1 HMGB2

1.79e-06247227863459
Pubmed

Conformational difference in HMGB1 proteins of human neutrophils and lymphocytes revealed by epitope mapping of a monoclonal antibody.

HMGB1 HMGB2

1.79e-06247215496585
Pubmed

Evidence for a shared structural role for HMG1 and linker histones B4 and H1 in organizing chromatin.

HMGB1 HMGB2

1.79e-0624728599938
Pubmed

The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

HMGB1 HMGB2

1.79e-0624728339930
Pubmed

cDNA sequence and structure of a trout HMG-2 gene. Evidence for a trout-specific 3'-untranslated region.

HMGB1 HMGB2

1.79e-0624727607539
Pubmed

Non-histone chromosomal proteins HMG1 and 2 enhance ligation reaction of DNA double-strand breaks.

HMGB1 HMGB2

1.79e-0624729600082
Pubmed

HMGB proteins and arthritis.

HMGB1 HMGB2

1.79e-06247228916968
Pubmed

Involvement of high mobility group B proteins in cisplatin-induced cytotoxicity in squamous cell carcinoma of skin.

HMGB1 HMGB2

1.79e-06247219435426
Pubmed

The Effect of HMGB1 and HMGB2 on Transcriptional Regulation Differs in Neuroendocrine and Adenocarcinoma Models of Prostate Cancer.

HMGB1 HMGB2

1.79e-06247238542079
Pubmed

Recent integrations of mammalian Hmg retropseudogenes.

HMGB1 HMGB2

1.79e-06247217406091
Pubmed

Loss of SPEF2 function in mice results in spermatogenesis defects and primary ciliary dyskinesia.

AKAP4 SPEF2

1.79e-06247221715716
Pubmed

The combination of a nuclear HMGB1-positive and HMGB2-negative expression is potentially associated with a shortened survival in patients with pancreatic ductal adenocarcinoma.

HMGB1 HMGB2

1.79e-06247225060178
Pubmed

Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin.

HMGB1 HMGB2

1.79e-06247218798064
Pubmed

Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2.

HMGB1 HMGB2

1.79e-06247211262228
Pubmed

Correlation of serum HMGB1 and HMGB2 levels with clinical symptoms in allergic rhinitis children.

HMGB1 HMGB2

1.79e-06247237713866
Pubmed

Nonhistone Proteins HMGB1 and HMGB2 Differentially Modulate the Response of Human Embryonic Stem Cells and the Progenitor Cells to the Anticancer Drug Etoposide.

HMGB1 HMGB2

1.79e-06247233076532
Pubmed

Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes.

HMGB1 HMGB2

1.79e-06247212925773
Pubmed

Interactions of HMGB Proteins with the Genome and the Impact on Disease.

HMGB1 HMGB2

1.79e-06247234680084
Pubmed

The HMG-1 box protein family: classification and functional relationships.

HMGB1 HMGB2

1.79e-0624727784217
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

HMGB1 RRP15 HBS1L YTHDC2 SMARCA5 UTP18 TCOF1 NIPBL GARS1 DDX10 ZRANB2

2.35e-061425471130948266
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

HMGB1 RRP15 HMGB2 HMGB3 YTHDC2 SMARCA5 TCOF1 HMGB1P1 GARS1 ZRANB2

2.62e-061153471029845934
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

HMGB1 RRP15 HMGB2 HMGB3 SMARCA5 UTP18 LATS2 NIPBL FAM161A SPEF2 GARS1

2.63e-061442471135575683
Pubmed

HMGB factors are required for posterior digit development through integrating signaling pathway activities.

HMGB1 HMGB2 HMGB3

3.50e-062247321384471
Pubmed

Identification of the core-histone-binding domains of HMG1 and HMG2.

HMGB1 HMGB2

5.36e-0634723697355
Pubmed

The RAG1 homeodomain recruits HMG1 and HMG2 to facilitate recombination signal sequence binding and to enhance the intrinsic DNA-bending activity of RAG1-RAG2.

HMGB1 HMGB2

5.36e-06347210490593
Pubmed

The major miR-31 target genes STK40 and LATS2 and their implications in the regulation of keratinocyte growth and hair differentiation.

STK40 LATS2

5.36e-06347228419554
Pubmed

High mobility group proteins stimulate DNA cleavage by apoptotic endonuclease DFF40/CAD due to HMG-box interactions with DNA.

HMGB1 HMGB2

5.36e-06347218239742
Pubmed

A novel RAG1 mutation reveals a critical in vivo role for HMGB1/2 during V(D)J recombination.

HMGB1 HMGB2

5.36e-06347230538136
Pubmed

High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro.

HMGB1 HMGB2

5.36e-0634729722660
Pubmed

Characterizing ZC3H18, a Multi-domain Protein at the Interface of RNA Production and Destruction Decisions.

RRP15 YTHDC2 SMARCA5 UTP18 TCOF1 SMNDC1 DDX10 ZRANB2

5.59e-0673147829298432
Pubmed

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

TIAM1 VAV2

1.07e-05447212810717
Pubmed

The role of the C-terminal extension (CTE) of the estrogen receptor alpha and beta DNA binding domain in DNA binding and interaction with HMGB.

HMGB1 HMGB2

1.07e-05447214739282
Pubmed

A nuclear protein complex containing high mobility group proteins B1 and B2, heat shock cognate protein 70, ERp60, and glyceraldehyde-3-phosphate dehydrogenase is involved in the cytotoxic response to DNA modified by incorporation of anticancer nucleoside analogues.

HMGB1 HMGB2

1.07e-05447212517784
Pubmed

Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins.

HMGB1 HMGB2

1.07e-05447211099378
Pubmed

HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter.

HMGB1 HMGB2

1.07e-05447211748232
Pubmed

Interaction proteomics of the HMGA chromatin architectural factors.

HMGB1 HMGB2 HMGB3

1.12e-053247318850631
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

HMGB1 HMGB2 HMGB3 YTHDC2 UTP18 TCOF1 DDX10 ZRANB2

1.15e-0580747822681889
Pubmed

HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.

HMGB1 HMGB2

1.78e-05547219223331
Pubmed

High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells.

HMGB1 HMGB2

1.78e-0554729671457
Pubmed

Rap1 promotes cell spreading by localizing Rac guanine nucleotide exchange factors.

TIAM1 VAV2

1.78e-05547215479739
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

AKAP13 TIAM1 VAV2

1.89e-053847319911011
Pubmed

Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.

AKAP13 TIAM1 VAV2

1.89e-053847311756498
Pubmed

Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover.

HMGB1 RRP15 HMGB3 NIPBL SMNDC1 ZRANB2

2.26e-0542547624999758
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RRP15 AKAP13 ITPRID2 UTP18 TIAM1 TCOF1 SMNDC1 CCDC18 DDX10 ZRANB2

2.41e-051487471033957083
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PACS1 AKAP13 ANKRD12 LATS2 PRKAG2 ARMC2 TMEM98 VAV2 KIAA1217 BICD1

2.44e-051489471028611215
Pubmed

Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis.

HMGB1 HMGB2

2.67e-05647219139395
Pubmed

NRAGE, a p75 neurotrophin receptor-interacting protein, induces caspase activation and cell death through a JNK-dependent mitochondrial pathway.

AKAP13 TIAM1 VAV2

2.75e-054347312376548
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

SYNRG YTHDC2 SMARCA5 TCOF1 NIPBL KIAA1217 AHNAK2 DDX10

3.26e-0593447833916271
Pubmed

In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail.

HMGB1 HMGB2

3.74e-05747215005629
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

HMGB1 RRP15 HMGB2 HMGB3 SMARCA5 NIPBL HMGB1P1 DDX10

3.79e-0595447836373674
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

RRP15 YTHDC2 SMARCA5 DDX10 ZRANB2

3.99e-0528347530585729
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HMGB1 RRP15 HMGB2 YTHDC2 SMARCA5 ITPRID2 UTP18 KIAA1217 GARS1

4.04e-05125747936526897
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RRP15 SMARCA5 UTP18 TCOF1 SMNDC1 GARS1 DDX10 ZRANB2

4.89e-0598947836424410
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

AKAP13 SMARCA5 UTP18 TCOF1 NIPBL SMNDC1

5.77e-0550347616964243
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

HMGB1 RRP15 HBS1L SMARCA5 UTP18 TCOF1 NIPBL GARS1 DDX10

5.82e-05131847930463901
Pubmed

Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.

HMGB1 RRP15 SMARCA5 TCOF1 DDX10 ZRANB2

5.96e-0550647630890647
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RRP15 AKAP13 HBS1L SMARCA5 UTP18 NIPBL GARS1 AHNAK2 DDX10

7.12e-05135347929467282
Pubmed

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

AKAP13 TIAM1 VAV2

7.50e-056047312787561
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

YTHDC2 SMARCA5 ITPRID2 UTP18 DDX10

8.49e-0533247525693804
Pubmed

The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.

RRP15 YTHDC2 SMARCA5 UTP18 DDX10

1.07e-0434947525665578
Pubmed

Human transcription factor protein interaction networks.

HOXA5 HMGB1 RRP15 HMGB2 HMGB3 SMARCA5 STK40 NIPBL DDX10

1.08e-04142947935140242
Pubmed

Delineating the HMGB1 and HMGB2 interactome in prostate and ovary epithelial cells and its relationship with cancer.

HMGB1 HMGB2 SMARCA5 ZRANB2

1.23e-0418847429721183
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

PACS1 TCOF1 NIPBL KIAA1217 AHNAK2

1.24e-0436047533111431
Pubmed

Defining the NSD2 interactome: PARP1 PARylation reduces NSD2 histone methyltransferase activity and impedes chromatin binding.

HMGB1 SMARCA5 TCOF1

1.29e-047247331248990
Pubmed

RhoG signals in parallel with Rac1 and Cdc42.

TIAM1 VAV2

1.38e-041347212376551
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SYNRG AKAP13 ITPRID2 TIAM1 KIAA1217 AHNAK2 CCDC18

1.48e-0486147736931259
Pubmed

The sperm-associated antigen 6 interactome and its role in spermatogenesis.

AKAP4 NIPBL SPEF2 ZRANB2

1.53e-0419947431146259
Pubmed

Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2.

HMGB1 HMGB2 HMGB3

1.58e-047747319505873
Pubmed

Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.

HMGB2 SMARCA5 TCOF1

1.70e-047947314729942
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

HMGB1 HMGB2 AKAP13 SMARCA5 TIAM1 SMNDC1 VAV2

2.16e-0491647732203420
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

YTHDC2 SMARCA5 UTP18 TCOF1 NIPBL DDX10

2.39e-0465347622586326
Pubmed

Identification of casein kinase Ialpha interacting protein partners.

HMGB1 HMGB2

2.40e-041747212062430
Pubmed

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.

HMGB1 RRP15 SMARCA5 UTP18 DDX10

2.82e-0443047538172120
Pubmed

Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.

PACS1 KIAA1217

3.01e-041947223563609
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

HMGB1 RRP15 SMARCA5 UTP18 TCOF1 NIPBL SMNDC1 C16orf87

3.10e-04129447830804502
Pubmed

Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.

HMGB3 HBS1L YTHDC2 ITPRID2

3.22e-0424247434011540
Pubmed

ATG5 is required for B cell polarization and presentation of particulate antigens.

AKAP13 YTHDC2 SMARCA5 UTP18 SMNDC1 ZRANB2

3.49e-0470147630196744
Pubmed

The LIFEdb database in 2006.

HMGB3 STK40 ARMC2 TMEM98 FAM161A VAV2

4.02e-0472047616381901
Pubmed

From ORFeome to biology: a functional genomics pipeline.

HMGB3 STK40 ARMC2 TMEM98 FAM161A VAV2

4.08e-0472247615489336
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

HMGB1 HMGB3 UTP18 CLIP2 SMNDC1 ZRANB2

4.11e-0472347634133714
Pubmed

SNIP1 Recruits TET2 to Regulate c-MYC Target Genes and Cellular DNA Damage Response.

TCOF1 NIPBL DDX10 ZRANB2

4.17e-0425947430404004
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

RRP15 YTHDC2 SMARCA5 ITPRID2 TCOF1 NIPBL DDX10

4.23e-04102447724711643
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

YTHDC2 LATS2 KIAA1217 AHNAK2

4.41e-0426347434702444
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

HMGB3 SMARCA5 UTP18 TCOF1 VAV2 GARS1 AHNAK2 ZRANB2

4.48e-04136747832687490
Pubmed

The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.

RRP15 YTHDC2 SMARCA5 UTP18 DDX10

4.80e-0448347536912080
Pubmed

The HMGB1-2 Ovarian Cancer Interactome. The Role of HMGB Proteins and Their Interacting Partners MIEN1 and NOP53 in Ovary Cancer and Drug-Response.

HMGB1 HMGB2

4.84e-042447232867128
Pubmed

Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif.

KIAA1217 BICD1

5.26e-042547212522145
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

AKAP13 HBS1L SMARCA5 TCOF1 NIPBL GARS1 AHNAK2 ZRANB2

5.62e-04141547828515276
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

HMGB1 HMGB3 SMARCA5 TCOF1 NIPBL SMNDC1 ZRANB2

5.87e-04108247738697112
Pubmed

Structure--function relationships in HIV-1 Nef.

PACS1 VAV2

6.14e-042747211463741
Pubmed

PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.

HMGB1 HMGB2 HMGB3 NIPBL SMNDC1 GARS1 ZRANB2

6.58e-04110347734189442
Pubmed

DNA cloning using in vitro site-specific recombination.

HMGB3 STK40 ARMC2 TMEM98 FAM161A VAV2

6.72e-0479447611076863
Pubmed

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.

RRP15 HMGB3 TCOF1 AHNAK2

6.79e-0429547426209609
InteractionH2BC8 interactions

RRP15 HMGB2 HMGB3 SMARCA5 NIPBL SMNDC1 C16orf87 DDX10 ZRANB2

6.18e-06576479int:H2BC8
InteractionMYCN interactions

HMGB1 RRP15 HMGB2 HMGB3 AKAP13 YTHDC2 SMARCA5 UTP18 TCOF1 SMNDC1 GARS1 DDX10 ZRANB2

1.02e-0513734713int:MYCN
InteractionPOLR1G interactions

HMGB1 RRP15 HMGB2 UTP18 TCOF1 NIPBL DDX10 ZRANB2

1.55e-05489478int:POLR1G
InteractionYWHAH interactions

PACS1 HMGB1 SYNRG HMGB3 AKAP13 ITPRID2 LATS2 TIAM1 KIAA1217 AHNAK2 CCDC18

3.51e-0511024711int:YWHAH
InteractionPOC5 interactions

FAM161A GARS1 BICD1 CCDC18

7.08e-0595474int:POC5
InteractionZNF330 interactions

HMGB1 HMGB3 SMARCA5 NIPBL SMNDC1 DDX10 ZRANB2

7.26e-05446477int:ZNF330
InteractionCIT interactions

RRP15 HBS1L YTHDC2 SMARCA5 UTP18 LATS2 TCOF1 NIPBL SMNDC1 AHNAK2 BICD1 DDX10

9.02e-0514504712int:CIT
InteractionZC3H10 interactions

RRP15 YTHDC2 UTP18 RBPMS2 DDX10

1.00e-04200475int:ZC3H10
InteractionCBX3 interactions

HMGB1 HMGB2 HMGB3 SMARCA5 TCOF1 NIPBL SMNDC1 ZRANB2

1.11e-04646478int:CBX3
InteractionMAGEB2 interactions

RRP15 YTHDC2 SMARCA5 UTP18 DDX10 ZRANB2

1.52e-04349476int:MAGEB2
InteractionLIPA interactions

HBS1L KIAA1217 GARS1

1.57e-0445473int:LIPA
InteractionRPL31 interactions

HMGB1 RRP15 HMGB2 YTHDC2 UTP18 TCOF1 DDX10 ZRANB2

1.58e-04680478int:RPL31
InteractionZC3H18 interactions

HMGB1 RRP15 YTHDC2 SMARCA5 UTP18 TCOF1 SMNDC1 DDX10 ZRANB2

1.65e-04877479int:ZC3H18
InteractionPARP1 interactions

HMGB1 RRP15 HMGB2 HMGB3 YTHDC2 SMARCA5 ITPRID2 UTP18 NIPBL DDX10 ZRANB2

1.73e-0413164711int:PARP1
InteractionSFN interactions

HMGB1 SYNRG AKAP13 ITPRID2 TIAM1 AHNAK2 CCDC18 ZRANB2

1.78e-04692478int:SFN
InteractionCD44 interactions

HMGB1 LATS2 TIAM1 VAV2 GARS1

2.30e-04239475int:CD44
InteractionRPL3 interactions

HMGB1 RRP15 HMGB2 YTHDC2 UTP18 SMNDC1 AHNAK2 DDX10

2.38e-04722478int:RPL3
Cytoband13q12

HMGB1 ZMYM5

2.79e-042447213q12
Cytoband5p13.2

NIPBL SPEF2

4.68e-04314725p13.2
CytobandEnsembl 112 genes in cytogenetic band chr13q12

HMGB1 LATS2 ZMYM5

1.80e-03234473chr13q12
CytobandEnsembl 112 genes in cytogenetic band chr6q21

ARMC2 SLC16A10

6.89e-03121472chr6q21
GeneFamilyCanonical high mobility group

HMGB1 HMGB2 HMGB3

3.37e-0711243511
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AKAP13 TIAM1 VAV2

8.90e-0566243722
GeneFamilyZinc fingers MYND-type|A-kinase anchoring proteins

AKAP13 AKAP4

6.71e-0429242396
GeneFamilyPDZ domain containing

TIAM1 RGS3 AHNAK2

1.04e-031522431220
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

AKAP13 TIAM1 VAV2

2.47e-03206243682
CoexpressionFISCHER_DREAM_TARGETS

HMGB1 HMGB2 HMGB3 SMARCA5 TCOF1 NIPBL FAM161A SMNDC1 GARS1 CCDC18 DDX10

8.56e-079694711M149
CoexpressionMORI_IMMATURE_B_LYMPHOCYTE_DN

HMGB1 HMGB2 HMGB3 SMARCA5

2.16e-0591474M18917
CoexpressionERBB2_UP.V1_DN

RRP15 SMARCA5 ANKRD12 ITPRID2 TIAM1

2.71e-05197475M2635
CoexpressionGSE3691_IFN_PRODUCING_KILLER_DC_VS_CONVENTIONAL_DC_SPLEEN_DN

UTP18 FLACC1 SMNDC1 KIAA1217 RYR3

2.91e-05200475M6366
CoexpressionZWANG_CLASS_1_TRANSIENTLY_INDUCED_BY_EGF

AKAP13 ANKRD12 ITPRID2 STK40 PRKAG2 TIAM1 KIAA1217

5.24e-05550477M2611
CoexpressionBLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP

HMGB3 AKAP13 ITPRID2 TCOF1 ZMYM5 GPR107

6.60e-05389476M6520
CoexpressionSCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN

HMGB1 SMARCA5 TIAM1

7.27e-0545473M1369
CoexpressionSCHAEFFER_SOX9_TARGETS_IN_PROSTATE_DEVELOPMENT_DN

HMGB1 SMARCA5 TIAM1

7.27e-0545473MM576
ToppCellH1299-infected|H1299 / Cell line, Condition and Strain

HMGB2 ANKRD12 TCOF1 AHNAK2 CCDC18

1.60e-061924659cf8049bdc3e0f81ce69042beac72b08d8f38b4e
ToppCellNon-neuronal-Dividing-IPC|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 TMEM98 CCDC18

1.95e-06200465971533181daa1bfac1f1b8c507d2013f891f9078
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

AKAP13 SMARCA5 ANKRD12 NIPBL ZRANB2

1.95e-0620046512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellControl-NK|Control / Disease group and Cell class

LATS2 TIAM1 VAV2 SLC16A10

2.71e-05168464683d389c8a1e791bfc773e63148115a21a6566db
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

HMGB1 HMGB2 HMGB3 CCDC18

3.47e-051794646718cadcc2d3b64717ed84244ef1242d392662dc
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_VWA2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AKAP13 VAV2 KIAA1217 RYR3

3.70e-0518246472e65a23cd36085bc880087d3cae92395de918a1
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

AKAP13 VAV2 KIAA1217 RYR3

3.70e-0518246405c167158815bf25d509df59ab386e1990712765
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(15)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

HMGB1 HMGB2 HMGB3 CCDC18

3.95e-051854646aeae77a087d695b1e58c5f63265e7113aa2e343
ToppCelldroplet-Bladder-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGB1 SMARCA5 ANKRD12 NIPBL

4.11e-05187464663991a8afe652e92363b64bcbd68c14d0307f0e
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PACS1 TIAM1 RGS3 DDX10

4.11e-051874643699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

PACS1 TIAM1 RGS3 DDX10

4.11e-05187464033ba52c0c2f9978784947098fa697368ae44834
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.29e-0518946406c44746fa4f02e6e2b3b635cdf2d8dfef3754d3
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.38e-05190464d19bc44310c53726e2f5f6a2bd377bbbf1d1983f
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-pro_B_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HMGB1 HMGB2 SMARCA5 ZRANB2

4.38e-05190464f623f0bdece6002b68ac2207e99408b24a2b1194
ToppCell5'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

4.38e-05190464cd37ccd30c27cf65eda0a9165f35b7672f5acaf6
ToppCellStriatum-Macroglia-POLYDENDROCYTE|Striatum / BrainAtlas - Mouse McCarroll V32

HMGB1 HMGB2 SMARCA5 TMEM98

4.47e-051914646bc9c7c86040f3ebce08c350e625e345581d4550
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.47e-051914649c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.56e-05192464dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellProliferating|World / shred by cell class for mouse tongue

HMGB1 HMGB2 HMGB3 CCDC18

4.56e-05192464f081f3f957cc782294e118fcc1055f6a4264ee98
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-0519346453bcd50892c379b2a571751f6eb1062436339fe7
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-05193464c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-05193464d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-051934644979862c0c16e6b4baa4c79894f1d237c861f5a5
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-051934648b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCelldroplet-Tongue-nan-24m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGB1 HMGB2 TCOF1 CCDC18

4.65e-05193464f20b90e3f3f5c9a1ae51c5ebe6d3adb954a142f2
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-051934642c15186d15545804cc262da9137ab825609d4b2c
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-05193464010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-051934643ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-051934642189da4b727e25e62669d7b9257f06493be21a27
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ARMC2 FAM161A SPEF2 AHNAK2

4.65e-05193464ea345d34440b25f65358a53dc72831998d1c3620
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-05193464e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-05193464658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.65e-051934645581a5ebcd21a2a8062ccfb917f088ec67a10a9c
ToppCelldroplet-Tongue-nan-3m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGB1 HMGB2 HMGB3 CCDC18

4.75e-051944642cac1b9c4da01faaec9a67ec06f47a7060760225
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.75e-05194464e5990880961d2469759ce4b3b20ae93ace3ebd1f
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.75e-051944641bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TIAM1 XKR4 VAV2 KIAA1217

4.75e-0519446483863da11dfbe59b2d0a2c08db40b537c150588c
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

4.84e-05195464742c82c86487314cdb3178012004adb1164bcbdb
ToppCelldroplet-Tongue-TONGUE-1m-Epithelial-proliferating|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HMGB1 HMGB2 TCOF1 CCDC18

4.84e-05195464b57132802cb977551e214880984f3edcd375474f
ToppCellTransverse-T_cell-Treg|T_cell / Region, Cell class and subclass

TIAM1 ZMYM5 C16orf87 SLC16A10

5.04e-05197464b7a1637e4baadd657f6279f4aa96cd590c9cd8c9
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

HMGB1 SMARCA5 ANKRD12 TCOF1

5.14e-051984644c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

5.14e-05198464c3dd887c95587f930b7afd32385627a9fa029ca4
ToppCellcycling_basal_cell|World / shred by cell class for bronchial biopsy

HMGB1 HMGB2 HMGB3 CCDC18

5.14e-05198464d5306121a75c5eb37d62c353799a98e6ba5ab63f
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HOXA5 HMGB1 HMGB2 HMGB3

5.14e-051984642ee8ac82ef1b8ebabc8dd824211bbb471f2af8ac
ToppCellNon-neuronal-Dividing-Radial_Glia-vRG-11|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 TMEM98

5.14e-05198464672c6faeed54e1397e12c0aac1a5cbd19c684f06
ToppCell3'-GW_trimst-1-SmallIntestine-Neuronal-Glial_immature-cycling_ENCC/glia|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 TIAM1

5.14e-05198464a11ac83dbd69d1c068971266d7c7343d114a6294
ToppCellNon-neuronal-Dividing-IPC-IPC-div1-28|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 CCDC18

5.24e-05199464787688b68ae5d8768c0a24673ae07ab07616764a
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-B_cells-Cycling_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

5.24e-05199464c9d15c84b9f8c87b4ea0008be7d5efc5f45efd1a
ToppCellNon-neuronal-Dividing-IPC-IPC-div1|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 CCDC18

5.24e-0519946472823f26ecabcae1b514b7629cfce010c97b929a
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

HMGB1 ANKRD12 NIPBL AHNAK2

5.24e-0519946418a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_Prolif-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

HMGB1 HMGB2 HMGB3 XKR4

5.24e-0519946453b3d35767889a152f1f38e8f6f0ba8f7a7690f2
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464a9cdddc4e985dae59521e557479c24fcc2ac727d
ToppCellNon-neuronal-Dividing-IPC-IPC-div2|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 TMEM98

5.34e-052004644923d7a4f00853c4d76fc1cc0fa82d522a2302e7
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464e79d93d55b25804f2608185168da472301b6ebca
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464858421b91f5207b7934b5c219752cb9322a3da31
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

ITPRID2 NIPBL KIAA1217 SPEF2

5.34e-05200464dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

5.34e-052004641fbed5967fc1922efe4a98f5760ad74fce210c52
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464347a510755374c6a66acee326565dfc447993f18
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1--L1-3|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464f3c710f0fc8a7bfb5371d1aff6e3d8f266953153
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

5.34e-0520046443571c9284d4e41402a2d1eefc1efe2ce8476d4a
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-052004641639982d9d994918f7912d12d9d7cfcbc9da4145
ToppCellNon-neuronal-Dividing-IPC-IPC-div2-5|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 TMEM98

5.34e-05200464dc1c1506823eaa105f1532c6b5d4efa14e788314
ToppCell(5)_Epi_dividing|World / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

HMGB1 HMGB2 HMGB3 TCOF1

5.34e-05200464948c55aa1c25f8a69b1bd3ef53fd32aa222f592c
ToppCellNon-neuronal-Dividing-Radial_Glia-vRG|World / Primary Cells by Cluster

HMGB1 HMGB2 HMGB3 TMEM98

5.34e-052004647596143925cd403ec7baceef87d19d570e48586a
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6--L3-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-0520046433b9199e0dfc267e2cea20b82d1c167f8adcc635
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

5.34e-0520046463f9481059be608ddc9fe9c7a8f8503fce9755dd
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-ADGRG6|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-052004649719fabddc34051949468a7520289e3c750de4f8
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB--L2-4|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-052004645ec469267747dce3601c1d8ad01af89fa5b29acc
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-cycling_stromal|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3 CCDC18

5.34e-0520046438665128b54f4a81b53c961427aed67bf4e2510b
ToppCell(5)_Epithelial_cells-(5)_Epi_dividing|(5)_Epithelial_cells / Oesophagus cell shreds on cell class (v1) and cell subclass (v1)

HMGB1 HMGB2 HMGB3 TCOF1

5.34e-05200464b46b2064362efc64edf19ab2b21bc89047c9d943
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-CALB1-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-0520046470a06fd7fb8de2c8ec3e3182e4476ced049daeae
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-052004642131c8e7fa054b79906eaf60536da892438b09cd
ToppCellNeuronal-Inhibitory-iB|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-0520046445ddc5ef2caa87ada88327b63ba9b150a6bb3aa5
ToppCellNeuronal-Inhibitory-iB-iB_3(PVALB-SST)-FRZB-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TIAM1 XKR4 VAV2 KIAA1217

5.34e-05200464320d5a3a1e7da2fa8f1a164e29e180ec8ac9889c
ToppCellP28-Hematopoietic-Erythroid-enucleate_erythrocyte|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRP15 CLIP2 CCDC18

8.68e-0583463c7ff56d4c7582fc497057cf3d5497fbd13c183cc
ToppCellP28-Hematopoietic-Erythroid|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RRP15 CLIP2 CCDC18

8.68e-0583463e548e5c7b16c895b360a00f3d6fc1a7eb3d19294
ToppCellControl-NK|World / Disease group and Cell class

LATS2 TIAM1 VAV2

4.32e-04143463fe08adc9472dfd4242497d6c614d0490713261da
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PRKAG2 VAV2 BICD1

4.50e-04145463fd02d55755c35288a42ab08a82450b370aad35a7
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo4_Rxfp1_Chat|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

HOXA5 TIAM1 VAV2

4.50e-0414546378f5f4b96420c7f391e4d32a9ed151ed95fad90b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PRKAG2 GARIN2 BICD1

4.68e-04147463b66ccc710b3c04f6fc7fed69f3c892fc110e98fc
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIAM1 VAV2 RYR3

4.87e-0414946310ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellE16.5-samps|World / Age Group, Lineage, Cell class and subclass

HMGB1 HMGB2 HMGB3

4.87e-04149463e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCellVE-CD8-memory_CD4|VE / Condition, Cell_class and T cell subcluster

LRRC63 PACS1 RYR3

5.16e-041524639401b7770c1bdc87eba25e82922f5dd1c4fa37ee
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XKR4 FAM161A RYR3

5.88e-04159463fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XKR4 FAM161A RYR3

5.88e-04159463aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

XKR4 FAM161A RYR3

5.88e-041594638bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TIAM1 GPR107 SLC16A10

6.21e-0416246364353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell368C-Lymphocytic-CD4_T-cell-Treg_cell_4|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

TIAM1 GPR107 SLC16A10

6.32e-041634639f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-6|TCGA-Stomach / Sample_Type by Project: Shred V9

HMGB2 AKAP4 ITPRID2

6.32e-04163463c1a98d6776b685f20dde049715233e5c73ce3244
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AKAP4 FAM161A SPEF2

6.43e-04164463d9531848105d606adedde65426177cf851140e31
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HMGB1 HMGB2 HMGB3

6.43e-0416446372ef807895385ba23e30d19d12b1b0549a699690
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-4|TCGA-Colorectal / Sample_Type by Project: Shred V9

TCOF1 GARS1 DDX10

6.66e-0416646352293b8a74d46e6161fb6a2e7e86e51fd9e89a5b
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like-ILC3|GI_small-bowel / Manually curated celltypes from each tissue

HOXA5 LATS2 TIAM1

6.66e-04166463773673a5d0430640439845b264740bfbbdad0cb2
ToppCell3'_v3-GI_small-bowel-Lymphocytic_Invariant-Inducer-like|GI_small-bowel / Manually curated celltypes from each tissue

HOXA5 LATS2 TIAM1

6.78e-041674633ae46c6363da76c8e1f5579e6027bf88ed637a44
ToppCellmild_COVID-19-HSPC|mild_COVID-19 / disease group, cell group and cell class (v2)

HOXA5 TMEM98 FAM161A

6.90e-0416846390b33962adb77d8326dee403712118398b4d1315
ToppCellControl-Lymphoid-ILC_B|Lymphoid / Disease state, Lineage and Cell class

AKAP4 LATS2 TIAM1

6.90e-04168463d7118d39253ed9790908b850088ebfc5a86f4065
ToppCellPND03-Immune-Immune_Myeloid-Monocytic-Macrophage-iMON-iMON_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HMGB2 TIAM1 CCDC18

7.02e-041694634db49b7eaea34e6558ee73b01e76315e99cc880b
ToppCellDividing_Macrophages-IPF_04|World / lung cells shred on cell class, cell subclass, sample id

HMGB2 XKR4 CCDC18

7.02e-04169463bc859a103cad567caf50c3c3882d2d2017807c73
ToppCell5'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LRRC63 FLACC1 SPEF2

7.02e-04169463fba841664939c771881ba97f14ef1df6635c04ff
DrugNalidixic acid sodium salt hydrate; Down 200; 14.6uM; PC3; HT_HG-U133A

AKAP13 ANKRD12 NIPBL RGS3 GPR107 BICD1

3.02e-061964767367_DN
DrugAC1L36FJ

HMGB1 HMGB2 HMGB3

1.07e-0521473CID000083911
Drugmaleylacetoacetate

HMGB1 HMGB2 HMGB3

1.24e-0522473CID006453754
Drug3-hydroxyphenylacetic acid

HMGB1 HMGB2 HMGB3

1.62e-0524473CID000012122
DrugStallimycin

HMGB1 HMGB2 HMGB3 AKAP4

2.25e-0580474CID000003115
Drugirinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A

AKAP13 ANKRD12 TIAM1 NIPBL BICD1

2.91e-051744757530_DN
Drugperchlorate

PACS1 HMGB1 HMGB2 RYR3

3.58e-0590474CID000024247
DrugAzathioprine

HMGB1 HMGB2 CLIP2 FAM161A RBPMS2 SLC16A10 CCDC18 DDX10

4.41e-05639478ctd:D001379
DrugAH23848 hemicalcium salt hydrate; Down 200; 1uM; MCF7; HT_HG-U133A

PACS1 HBS1L VAV2 GPR107 SLC16A10

5.01e-051954756890_DN
DrugKawain [500-64-1]; Down 200; 17.4uM; PC3; HT_HG-U133A

AKAP13 TIAM1 ZMYM5 GPR107 BICD1

5.14e-051964757369_DN
Drugd(GpG

HMGB1 HMGB2 HMGB3

5.15e-0535473CID000161113
DrugEnalapril maleate [76095-16-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A

PACS1 YTHDC2 ANKRD12 NIPBL GPR107

5.39e-051984757428_UP
DrugCP-863187 [668981-07-5]; Up 200; 10uM; MCF7; HT_HG-U133A

PACS1 SYNRG ANKRD12 TIAM1 GPR107

5.39e-051984757553_UP
DrugCAY10397; Down 200; 10uM; MCF7; HT_HG-U133A

AKAP13 HBS1L ANKRD12 NIPBL RGS3

5.52e-051994757082_DN
Diseasemean corpuscular hemoglobin concentration

HMGB1 AKAP13 HBS1L ANKRD12 PRKAG2 KIAA1217 HMGB1P1 GARS1 SLC16A10

3.68e-051105459EFO_0004528
Diseasemean reticulocyte volume

HMGB1 AKAP13 HBS1L ARMC2 KIAA1217 HMGB1P1 SLC16A10

1.93e-04799457EFO_0010701
Diseaseuric acid measurement

PACS1 HMGB1 AKAP13 PRKAG2 SLC16A10 CCDC18

3.13e-04610456EFO_0004761
Diseasered blood cell density measurement

HMGB1 AKAP13 HBS1L PRKAG2 RGS3 HMGB1P1 SLC16A10

3.46e-04880457EFO_0007978
Diseaseneutrophil percentage of granulocytes

AKAP13 HBS1L SPEF2 CCDC18

4.03e-04228454EFO_0007994
Diseaseeosinophil percentage of granulocytes

AKAP13 HBS1L SPEF2 CCDC18

4.45e-04234454EFO_0007996
Diseasefetal hemoglobin measurement

HBS1L YTHDC2

4.69e-0421452EFO_0004576
Diseaseobsolete_red blood cell distribution width

AKAP13 HBS1L ANKRD12 PRKAG2 KIAA1217 HMGB1P1 GARS1 SLC16A10

8.82e-041347458EFO_0005192
DiseaseStrabismus

RGS3 KIAA1217

8.99e-0429452HP_0000486
Diseasehippocampal volume

HMGB1 AKAP13 KIAA1217 RYR3

1.08e-03297454EFO_0005035
Diseasehemoglobin A1 measurement

AKAP13 HBS1L FLACC1 HMGB1P1 BICD1

1.14e-03520455EFO_0007629
DiseaseHOMA-IR

KIAA1217 SPEF2

1.17e-0333452EFO_0004501
Diseasechronic rhinosinusitis

GARIN2 SPEF2

1.24e-0334452EFO_1000024
Diseaseemphysema imaging measurement

ANKRD12 TIAM1 CCDC18

1.45e-03146453EFO_0007626
Diseasemultiple sclerosis

AKAP13 HBS1L VAV2 SPEF2 BICD1

2.04e-03594455MONDO_0005301
DiseaseMouth Neoplasms

HOXA5 TIAM1

3.09e-0354452C0026640
DiseaseMalignant neoplasm of mouth

HOXA5 TIAM1

3.09e-0354452C0153381

Protein segments in the cluster

PeptideGeneStartEntry
MGSAVMDTKKKKDVS

PRKAG2

1

Q9UGJ0
KTTKESGEKMAHMEK

BICD1

471

Q96G01
KAEMKERDKGKMKSD

AKAP4

471

Q5JQC9
KKTVESKETVMMGDS

ARMC2

156

Q8NEN0
TKTDSKSIMRMKSGQ

AKAP13

2206

Q12802
AKAKKTKRMAMGVSA

CLIP2

296

Q9UDT6
SDVSKEMKEKSSMKR

ANKRD12

46

Q6UB98
AKANTKMAKSKLMAT

RBPMS2

106

Q6ZRY4
GKADKMMKSFKPTSE

RGS3

1051

P49796
TTSGVMESMKKVKKV

GPR107

571

Q5VW38
MESMKKVKKVTNGSV

GPR107

576

Q5VW38
KVAKMTVSGKKQTMG

HBS1L

161

Q9Y450
GKDFMSKTPKAMATK

nan

991

O00370
TMSAKEKGKFEDMAK

HMGB1

51

P09429
KMTKKFEMESGEEDK

FLACC1

261

Q96Q35
AKMDKSMFVKIKTLG

LATS2

661

Q9NRM7
TMSAKEKSKFEDMAK

HMGB2

51

P26583
KKDNKLKSMSMAAAG

HOXA5

251

P20719
AKIKAMGIMDKLSTD

NIPBL

1246

Q6KC79
MGIMDKLSTDKTVKV

NIPBL

1251

Q6KC79
NKMESSRKFKTMKDV

LRRC63

126

Q05C16
IMKKKESSSMLATVK

ITPRID2

346

P28290
GTMAMTVVTKEKNKK

PACS1

871

Q6VY07
MSATRAKKVKMATKS

C16orf87

1

Q6PH81
SKGEMKKENMKKDEA

CCDC18

696

Q5T9S5
TMSGKEKSKFDEMAK

HMGB3

51

O15347
DMENKISDTKKKQGM

DDX10

811

Q13206
KKEESMKSKSDIEMV

FAM161A

251

Q3B820
SKEMKDKTSEEKMPD

GARIN2

361

Q8N9W8
RKDMMKNASESKLSK

UTP18

161

Q9Y5J1
KKKKSGLTGVEMQTM

SPEF2

106

Q9C093
VEDTESSRMVKKMKK

STK40

121

Q8N2I9
SKMKSSEEMIKSELA

SYNRG

1046

Q9UMZ2
MKEKAKAETEKAGKT

TCOF1

121

Q13428
MSDKKCSVEKKSEME

GARS1

226

P41250
TMSAKEKGKFEDMAK

HMGB1P1

51

B2RPK0
KDASSEKMMKTTANR

KIAA1217

591

Q5T5P2
LADKGMTAKDSKFKM

AHNAK2

2801

Q8IVF2
KKMGEMQLSSVTDSK

TIAM1

581

Q13009
SKSKMSKAMQVKSGG

RYR3

3331

Q15413
MAAKSDGRLKMKKSS

XKR4

1

Q5GH76
KKKMKMVTGAVASVL

RRP15

21

Q9Y3B9
REKTTEAKMMKAGGT

ZRANB2

36

O95218
TVKKKDGSETAHAMM

YTHDC2

101

Q9H6S0
KQMMETKSKKLTASE

ZMYM5

416

Q9UJ78
AKEDSGNKPMSKKEM

SMNDC1

131

O75940
KMTDDPMNNKDVKKS

VAV2

456

P52735
GAKKTAEMNEKLSKM

SMARCA5

681

O60264
EKLVAMTMGSGAKMK

TMEM98

106

Q9Y2Y6
SKTTGKEKMEKMLEN

SLC16A10

481

Q8TF71