Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	4.93e-15	114	146	15	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.77e-14	124	146	15	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	7.96e-14	137	146	15	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.13e-11	192	146	15	GO:0008234
GeneOntologyMolecularFunction	calcium ion binding	FBLN5 DLL4 PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET SVEP1 RYR3 SNED1 FBLN1 FBN1 FBN2 LRP1 RASEF ASTN2 PCDHGA8 FBN3 RAB11FIP3	5.65e-07	749	146	20	GO:0005509
GeneOntologyMolecularFunction	extracellular matrix structural constituent	FBLN5 VWF COL16A1 LAMA5 FBLN1 FBN1 FBN2 FBN3 IMPG2	1.02e-05	188	146	9	GO:0005201
GeneOntologyMolecularFunction	peptidase activity	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P ADAMTS18 USP17L22 USP17L15 USP17L13	2.45e-05	654	146	16	GO:0008233
GeneOntologyMolecularFunction	extracellular matrix constituent conferring elasticity	FBLN5 FBN1 FBN2	8.03e-05	12	146	3	GO:0030023
GeneOntologyMolecularFunction	structural molecule activity conferring elasticity	FBLN5 FBN1 FBN2	1.31e-04	14	146	3	GO:0097493
GeneOntologyMolecularFunction	integrin binding	FBLN5 VWF COL16A1 LAMA5 SVEP1 FBLN1 FBN1	3.07e-04	175	146	7	GO:0005178
GeneOntologyMolecularFunction	SUMO ligase activity	PIAS2 PIAS3 TRIM60	3.98e-04	20	146	3	GO:0061665
GeneOntologyMolecularFunction	ornithine decarboxylase regulator activity	AZIN1 OAZ3	5.23e-04	5	146	2	GO:0042979
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	KDM6A UTY	5.23e-04	5	146	2	GO:0071558
GeneOntologyMolecularFunction	hyaluronic acid binding	USP17L24 USP17L6P IMPG2	1.22e-03	29	146	3	GO:0005540
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.63e-13	125	146	14	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.89e-12	144	146	14	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L21 USP17L12 TRIM61 USP17L20 USP17L11 USP17L24 PHRF1 USP17L5 USP17L10 USP17L19 PIAS2 BIRC6 FBXL21P USP17L18 PIAS3 USP17L17 ASB10 ANAPC2 USP17L6P MINAR1 USP17L22 USP17L15 USP17L13 TRIM60	1.71e-07	1009	146	24	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L21 USP17L12 TRIM61 USP17L20 USP17L11 USP17L24 PHRF1 USP17L5 USP17L10 USP17L19 PIAS2 BIRC6 FBXL21P USP17L18 PIAS3 USP17L17 ASB10 ANAPC2 USP17L6P MINAR1 USP17L22 USP17L15 USP17L13 TRIM60	5.31e-07	1074	146	24	GO:0043687
GeneOntologyCellularComponent	extracellular matrix	FBLN5 VWF COL16A1 LAMA5 TFIP11 SVEP1 SNED1 FBLN1 FBN1 FBN2 LINGO1 ADAMTS18 FBN3 OTOG IMPG2	6.18e-05	656	147	15	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	FBLN5 VWF COL16A1 LAMA5 TFIP11 SVEP1 SNED1 FBLN1 FBN1 FBN2 LINGO1 ADAMTS18 FBN3 OTOG IMPG2	6.40e-05	658	147	15	GO:0030312
GeneOntologyCellularComponent	MLL3/4 complex	KMT2D KDM6A UTY	7.16e-05	12	147	3	GO:0044666
GeneOntologyCellularComponent	microfibril	FBN1 FBN2 FBN3	9.25e-05	13	147	3	GO:0001527
GeneOntologyCellularComponent	elastic fiber	FBLN5 FBLN1	4.84e-04	5	147	2	GO:0071953
HumanPheno	Abnormal pelvic girdle bone morphology	FBLN5 LAMA5 RET AP3B1 RYR3 PPP2R1A FBLN1 KMT2D FBN1 FBN2 BRCA2 TTC21B LRP1 LRP5 MYO18B KDM6A WNK3	1.36e-06	730	35	17	HP:0002644
HumanPheno	Abnormal hip bone morphology	FBLN5 LAMA5 RET AP3B1 RYR3 PPP2R1A FBLN1 KMT2D FBN1 FBN2 BRCA2 LRP1 LRP5 MYO18B KDM6A WNK3	1.70e-06	653	35	16	HP:0003272
HumanPheno	Recurrent acute respiratory tract infection	FBLN5 KMT2D CSF2RA KDM6A	4.17e-06	17	35	4	HP:0011948
HumanPheno	Abnormal hip joint morphology	FBLN5 LAMA5 AP3B1 RYR3 PPP2R1A FBLN1 KMT2D FBN1 FBN2 BRCA2 LRP1 MYO18B KDM6A	1.04e-05	490	35	13	HP:0001384
HumanPheno	Abnormal synovial membrane morphology	FBLN5 LAMA5 AP3B1 RYR3 PPP2R1A FBLN1 KMT2D FBN1 FBN2 BRCA2 LRP1 MYO18B KDM6A	1.39e-05	503	35	13	HP:0005262
HumanPheno	Bronchiolitis	FBLN5 KMT2D KDM6A	3.45e-05	10	35	3	HP:0011950
HumanPheno	Abnormal sclera morphology	MFRP RYR3 KMT2D FBN1 LRP5 KDM6A IMPG2	3.77e-05	141	35	7	HP:0000591
HumanPheno	Abnormal alveolar type II pneumocyte morphology	KMT2D KDM6A	1.37e-04	3	35	2	HP:0033245
HumanPheno	Decreased proportion of CD4-positive, alpha-beta memory T cells	KMT2D KDM6A	1.37e-04	3	35	2	HP:0410386
HumanPheno	Abnormal upper to lower segment ratio	FBN1 FBN2	1.37e-04	3	35	2	HP:0012772
HumanPheno	Type II pneumocyte hyperplasia	KMT2D KDM6A	1.37e-04	3	35	2	HP:0033328
HumanPheno	Abnormality of lower limb joint	FBLN5 LAMA5 RET AP3B1 RYR3 PPP2R1A FBLN1 KMT2D FBN1 FBN2 BRCA2 LRP1 LRP5 SLC39A14 MYO18B KDM6A WNK3	1.48e-04	1027	35	17	HP:0100491
HumanPheno	Joint dislocation	FBLN5 RYR3 FBLN1 KMT2D FBN1 FBN2 BRCA2 LRP1 KDM6A WNK3	1.99e-04	390	35	10	HP:0001373
HumanPheno	Lower extremity joint dislocation	FBLN5 RYR3 FBLN1 KMT2D FBN2 BRCA2 LRP1 KDM6A WNK3	2.13e-04	318	35	9	HP:0030311
HumanPheno	Scimitar anomaly	KMT2D KDM6A	2.73e-04	4	35	2	HP:0011626
MousePheno	overexpanded pulmonary alveolus	AP3B1 FBLN1 FBN1 ADAMTS18 SMPD3	7.12e-06	37	103	5	MP:0001183
Domain	HABP4_PAI-RBP1	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	1.52e-20	16	143	11	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	1.52e-20	16	143	11	IPR006861
Domain	USP_CS	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	8.78e-14	66	143	12	IPR018200
Domain	USP_1	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	1.85e-13	70	143	12	PS00972
Domain	UCH	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	2.21e-13	71	143	12	PF00443
Domain	USP_2	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	2.21e-13	71	143	12	PS00973
Domain	USP_3	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	2.64e-13	72	143	12	PS50235
Domain	USP_dom	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	2.64e-13	72	143	12	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L22 USP17L13	2.64e-13	72	143	12	IPR001394
Domain	EGF_3	FBLN5 DLL4 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 CNTNAP4 LRP5 ASTN2 FBN3 OTOG IMPG2	3.58e-09	235	143	14	PS50026
Domain	EGF-like_dom	FBLN5 DLL4 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 CNTNAP4 LRP5 FBN3 OTOG IMPG2	7.51e-09	249	143	14	IPR000742
Domain	EGF_1	FBLN5 DLL4 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 CNTNAP4 LRP5 ASTN2 FBN3 IMPG2	1.02e-08	255	143	14	PS00022
Domain	EGF_2	FBLN5 DLL4 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 CNTNAP4 LRP5 ASTN2 FBN3 IMPG2	1.66e-08	265	143	14	PS01186
Domain	cEGF	FBLN5 FBLN1 FBN1 FBN2 LRP1 FBN3	3.68e-08	26	143	6	PF12662
Domain	cEGF	FBLN5 FBLN1 FBN1 FBN2 LRP1 FBN3	3.68e-08	26	143	6	IPR026823
Domain	EGF-like_Ca-bd_dom	FBLN5 DLL4 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 LRP5 FBN3	3.91e-08	124	143	10	IPR001881
Domain	EGF_CA	FBLN5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 LRP5 FBN3	6.77e-08	99	143	9	PS01187
Domain	ASX_HYDROXYL	FBLN5 DLL4 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 FBN3	7.39e-08	100	143	9	PS00010
Domain	EGF-like_CS	FBLN5 DLL4 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 CNTNAP4 LRP5 FBN3 IMPG2	1.10e-07	261	143	13	IPR013032
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBLN5 DLL4 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 FBN3	1.23e-07	106	143	9	IPR000152
Domain	EGF	FBLN5 DLL4 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 CNTNAP4 LRP5 FBN3	2.64e-07	235	143	12	SM00181
Domain	Growth_fac_rcpt_	FBLN5 CRIM1 DLL4 LAMA5 SVEP1 FBLN1 FBN1 FBN2 LRP1 FBN3	3.41e-07	156	143	10	IPR009030
Domain	Cadherin_tail	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	3.47e-07	37	143	6	PF15974
Domain	Cadherin_CBD	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	3.47e-07	37	143	6	IPR031904
Domain	EGF_CA	FBLN5 DLL4 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 FBN3	4.11e-07	122	143	9	SM00179
Domain	FBN	FBN1 FBN2 FBN3	4.40e-07	3	143	3	IPR011398
Domain	Cadherin_C	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	7.58e-07	42	143	6	IPR032455
Domain	Cadherin_C_2	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	7.58e-07	42	143	6	PF16492
Domain	EGF_Ca-bd_CS	FBLN5 SVEP1 SNED1 FBLN1 FBN1 FBN2 LRP1 FBN3	7.90e-07	97	143	8	IPR018097
Domain	EGF_CA	FBLN5 SVEP1 FBLN1 FBN1 FBN2 LRP1 FBN3	4.32e-06	86	143	7	PF07645
Domain	Cadherin_2	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	1.03e-05	65	143	6	PF08266
Domain	Cadherin_N	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	1.03e-05	65	143	6	IPR013164
Domain	TB	FBN1 FBN2 FBN3	1.50e-05	7	143	3	PF00683
Domain	-	FBN1 FBN2 FBN3	2.39e-05	8	143	3	3.90.290.10
Domain	Cadherin	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET PCDHGA8	2.61e-05	113	143	7	PF00028
Domain	CADHERIN_2	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET PCDHGA8	2.77e-05	114	143	7	PS50268
Domain	-	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET PCDHGA8	2.77e-05	114	143	7	2.60.40.60
Domain	CA	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET PCDHGA8	2.93e-05	115	143	7	SM00112
Domain	Cadherin-like	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET PCDHGA8	3.10e-05	116	143	7	IPR015919
Domain	Cadherin	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 RET PCDHGA8	3.46e-05	118	143	7	IPR002126
Domain	TB_dom	FBN1 FBN2 FBN3	3.57e-05	9	143	3	IPR017878
Domain	TB	FBN1 FBN2 FBN3	3.57e-05	9	143	3	PS51364
Domain	EGF	DLL4 SVEP1 SNED1 LRP1 CNTNAP4 LRP5 FBN3	5.26e-05	126	143	7	PF00008
Domain	TMEM183	TMEM183A TMEM183BP	5.82e-05	2	143	2	IPR026509
Domain	hEGF	SVEP1 SNED1 FBN2 FBN3	5.85e-05	28	143	4	PF12661
Domain	Cadherin_CS	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	1.92e-04	109	143	6	IPR020894
Domain	CADHERIN_1	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	2.34e-04	113	143	6	PS00232
Domain	PINIT	PIAS2 PIAS3	3.46e-04	4	143	2	PS51466
Domain	PINIT	PIAS2 PIAS3	3.46e-04	4	143	2	PF14324
Domain	PINIT	PIAS2 PIAS3	3.46e-04	4	143	2	IPR023321
Domain	VWC_out	VWF CRIM1 OTOG	3.89e-04	19	143	3	SM00215
Domain	ARM-like	MROH5 API5 AP3B1 PPP2R1A MROH1 ZER1 RIPOR1 PPP6R2	1.14e-03	270	143	8	IPR011989
Domain	zf-MIZ	PIAS2 PIAS3	1.19e-03	7	143	2	PF02891
Domain	ZF_SP_RING	PIAS2 PIAS3	1.19e-03	7	143	2	PS51044
Domain	ARM-type_fold	MROH5 API5 AP3B1 RYR3 PPP2R1A MROH1 ZER1 RIPOR1 PPP6R2	1.22e-03	339	143	9	IPR016024
Domain	ConA-like_dom	COL16A1 LAMA5 SVEP1 RYR3 PTPRK CNTNAP4 TRIM60	1.51e-03	219	143	7	IPR013320
Domain	Znf_MIZ	PIAS2 PIAS3	1.58e-03	8	143	2	IPR004181
Domain	-	MROH5 API5 AP3B1 PPP2R1A MROH1 ZER1 RIPOR1	1.63e-03	222	143	7	1.25.10.10
Domain	-	LRRC10 LRCH1 ADGRA2 FBXL21P LINGO1 ZER1 LRRC28 NLRP4	3.34e-03	321	143	8	3.80.10.10
Domain	LDLR_class-A_CS	MFRP LRP1 LRP5	3.53e-03	40	143	3	IPR023415
Domain	C8	VWF OTOG	3.65e-03	12	143	2	PF08742
Domain	Quinoprot_gluc/sorb_DH	MED16 LRP1	3.65e-03	12	143	2	IPR011041
Domain	TIL	VWF OTOG	3.65e-03	12	143	2	PF01826
Domain	L_dom-like	LRRC10 LRCH1 ADGRA2 FBXL21P LINGO1 ZER1 LRRC28 NLRP4	3.81e-03	328	143	8	IPR032675
Domain	VWF_dom	VWF CRIM1 OTOG	4.06e-03	42	143	3	IPR001007
Domain	Unchr_dom_Cys-rich	VWF OTOG	4.30e-03	13	143	2	IPR014853
Domain	C8	VWF OTOG	4.30e-03	13	143	2	SM00832
Domain	Ldl_recept_a	MFRP LRP1 LRP5	4.93e-03	45	143	3	PF00057
Domain	TIL_dom	VWF OTOG	4.99e-03	14	143	2	IPR002919
Domain	Ldl_recept_b	LRP1 LRP5	4.99e-03	14	143	2	PF00058
Domain	LDLRB	LRP1 LRP5	4.99e-03	14	143	2	PS51120
Domain	-	MFRP LRP1 LRP5	5.24e-03	46	143	3	4.10.400.10
Domain	LY	LRP1 LRP5	5.73e-03	15	143	2	SM00135
Domain	LDLR_classB_rpt	LRP1 LRP5	5.73e-03	15	143	2	IPR000033
Domain	LDLRA_1	MFRP LRP1 LRP5	5.91e-03	48	143	3	PS01209
Domain	-	COL16A1 LAMA5 SVEP1 CNTNAP4	6.12e-03	95	143	4	2.60.120.200
Domain	LDrepeatLR_classA_rpt	MFRP LRP1 LRP5	6.26e-03	49	143	3	IPR002172
Domain	LDLa	MFRP LRP1 LRP5	6.26e-03	49	143	3	SM00192
Domain	LDLRA_2	MFRP LRP1 LRP5	6.26e-03	49	143	3	PS50068
Domain	VWF_type-D	VWF OTOG	6.51e-03	16	143	2	IPR001846
Domain	VWFD	VWF OTOG	6.51e-03	16	143	2	PS51233
Domain	VWD	VWF OTOG	6.51e-03	16	143	2	SM00216
Domain	VWD	VWF OTOG	6.51e-03	16	143	2	PF00094
Domain	HEAT_type_2	PPP2R1A MROH1	7.34e-03	17	143	2	IPR021133
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.71e-18	45	99	13	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 KAT2A USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	6.05e-11	191	99	14	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 KAT2A USP17L18 USP17L17 USP17L22 USP17L15 USP17L13	4.21e-10	221	99	14	M27578
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 VWF USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 RET USP17L18 PPP2R1A USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	6.43e-10	318	99	16	MM15278
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 KAT2A USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.86e-09	262	99	14	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 KAT2A USP17L18 USP17L17 USP17L22 USP17L15 USP17L13	2.07e-08	299	99	14	M27574
Pathway	REACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES	FBLN5 FBLN1 FBN1 FBN2 FBN3	5.63e-06	37	99	5	M27134
Pathway	REACTOME_ELASTIC_FIBRE_FORMATION	FBLN5 FBLN1 FBN1 FBN2 FBN3	1.35e-05	44	99	5	M26969
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 KAT2A THSD7B PIAS2 FBXL21P USP17L18 FBN1 GPIHBP1 PIAS3 USP17L17 ST6GALNAC3 ASB10 USP17L6P ADAMTS18 USP17L22 USP17L15 USP17L13	7.24e-05	1389	99	23	MM15307
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	FBLN5 VWF COL16A1 LAMA5 FBLN1 FBN1 FBN2 ADAMTS18 FBN3	2.57e-04	300	99	9	M610
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	COL16A1 LAMA5 FBN1 FBN2 ADAMTS18 FBN3	4.53e-04	140	99	6	M587
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 KAT2A THSD7B PIAS2 USP17L18 FBN1 GPIHBP1 PIAS3 USP17L17 ST6GALNAC3 ASB10 ADAMTS18 USP17L22 USP17L15 USP17L13	4.78e-04	1475	99	22	M19806
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.07e-26	21	150	13	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.07e-26	21	150	13	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.07e-26	21	150	13	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.07e-26	21	150	13	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.07e-26	21	150	13	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.07e-26	21	150	13	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.05e-26	22	150	13	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.51e-25	24	150	13	8995226
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.16e-25	33	150	14	20228807
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.22e-25	25	150	13	21115691
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	20403174
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	14699124
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	11941478
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	20388806
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	20368735
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.35e-25	34	150	14	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	8.88e-25	35	150	14	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	8.88e-25	35	150	14	21239494
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.04e-24	26	150	13	35816173
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.45e-24	36	150	14	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.32e-24	37	150	14	20228808
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	6.71e-24	29	150	13	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	3.25e-20	50	150	13	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 KMT2D FBN1 FBN2 USP17L17 BTN2A3P USP17L6P USP17L22 KDM6A UTY USP17L15 WNK3 USP17L13	1.47e-11	674	150	20	37196079
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L20 USP17L11 PCDHGA2 USP17L19 USP17L18 CSF2RA USP17L17	2.62e-09	119	150	9	28625976
Pubmed	Functional proteomics mapping of a human signaling pathway.	VWF ZFYVE16 LAMA5 PIAS2 SVEP1 TRAK1 PPP2R1A FBLN1 KMT2D FBN2 PIAS3 ANAPC2 LRP1 ASCC2 LRP5 KDM6A	6.65e-09	591	150	16	15231748
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	VWF FBLN1 FBN1 FBN2	4.12e-08	9	150	4	12122015
Pubmed	Heparin/heparan sulfate controls fibrillin-1, -2 and -3 self-interactions in microfibril assembly.	FBN1 FBN2 FBN3	3.14e-07	4	150	3	25034023
Pubmed	Comparative DNA sequence analysis of mouse and human protocadherin gene clusters.	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	5.11e-07	68	150	6	11230163
Pubmed	A striking organization of a large family of human neural cadherin-like cell adhesion genes.	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	7.19e-07	72	150	6	10380929
Pubmed	Fibrillin-1 interactions with fibulins depend on the first hybrid domain and provide an adaptor function to tropoelastin.	FBLN5 FBN1 FBN2	7.81e-07	5	150	3	17255108
Pubmed	Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	8.47e-07	74	150	6	10817752
Pubmed	ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells.	LAMA5 FBN1 FBN2 ADAMTS18	9.70e-07	18	150	4	39040056
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	1.07e-06	77	150	6	10835267
Pubmed	Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes.	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	1.34e-06	80	150	6	10716726
Pubmed	Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.	KMT2D ASCC2 KDM6A UTY	1.53e-06	20	150	4	19047629
Pubmed	Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.	FBLN5 VWF COL16A1 LAMA5 FBLN1 FBN1 FBN2	2.10e-06	135	150	7	28675934
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	CRIM1 OBSCN LAMA5 ADGRA2 LRP1 LRP5 PCCB KDM6A	4.48e-06	214	150	8	22199357
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	LAMA5 FBN1 FBN2 ADAMTS18	4.62e-06	26	150	4	34189436
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	OBSCN LMTK2 LAMA5 ZFPM1 KAT2A FHIP1B ADGRA2 BIRC6 TRAK1 KMT2D MROH1 LRP5 ZER1 RIPOR1 HMGXB3 AHNAK2 RAB11FIP3	6.20e-06	1105	150	17	35748872
Pubmed	ADAMTS18 Deficiency Leads to Pulmonary Hypoplasia and Bronchial Microfibril Accumulation.	FBLN5 FBN1 FBN2 ADAMTS18	8.35e-06	30	150	4	32882513
Pubmed	Polymorphism discovery in 62 DNA repair genes and haplotype associations with risks for lung and head and neck cancers.	POLR2B MLH3 POLK	9.23e-06	10	150	3	17494052
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	CEP85 CRIM1 KMT2D FBN1 FBN2 LRP1 PCCB	1.61e-05	184	150	7	32908313
Pubmed	Homo- and heterotypic fibrillin-1 and -2 interactions constitute the basis for the assembly of microfibrils.	FBN1 FBN2	1.85e-05	2	150	2	12399449
Pubmed	Fibrillin-1 and fibrillin-2 are essential for formation of thick oxytalan fibers in human nonpigmented ciliary epithelial cells in vitro.	FBN1 FBN2	1.85e-05	2	150	2	21851253
Pubmed	New Evidence Supporting the Role of FBN1 in the Development of Adolescent Idiopathic Scoliosis.	FBN1 FBN2	1.85e-05	2	150	2	30044367
Pubmed	Material and mechanical properties of bones deficient for fibrillin-1 or fibrillin-2 microfibrils.	FBN1 FBN2	1.85e-05	2	150	2	21440062
Pubmed	MAGP-2 has multiple binding regions on fibrillins and has covalent periodic association with fibrillin-containing microfibrils.	FBN1 FBN2	1.85e-05	2	150	2	15131124
Pubmed	Identification of KMT2D and KDM6A mutations by exome sequencing in Korean patients with Kabuki syndrome.	KMT2D KDM6A	1.85e-05	2	150	2	24739679
Pubmed	An H-YDb epitope is encoded by a novel mouse Y chromosome gene.	KDM6A UTY	1.85e-05	2	150	2	8944031
Pubmed	Identification of KMT2D and KDM6A variants by targeted sequencing from patients with Kabuki syndrome and other congenital disorders.	KMT2D KDM6A	1.85e-05	2	150	2	31935506
Pubmed	Microfibril structure masks fibrillin-2 in postnatal tissues.	FBN1 FBN2	1.85e-05	2	150	2	20404337
Pubmed	Update of the genotype and phenotype of KMT2D and KDM6A by genetic screening of 100 patients with clinically suspected Kabuki syndrome.	KMT2D KDM6A	1.85e-05	2	150	2	32803813
Pubmed	Fibrillln mutations in Marfan syndrome and related phenotypes.	FBN1 FBN2	1.85e-05	2	150	2	8791520
Pubmed	Fibrillin genes map to regions of conserved mouse/human synteny on mouse chromosomes 2 and 18.	FBN1 FBN2	1.85e-05	2	150	2	8307578
Pubmed	Use of a common promoter by two juxtaposed and intronless mouse early embryonic genes, Rnf33 and Rnf35: implications in zygotic gene expression.	TRIM61 TRIM60	1.85e-05	2	150	2	12160726
Pubmed	Developmental expression of fibrillin genes suggests heterogeneity of extracellular microfibrils.	FBN1 FBN2	1.85e-05	2	150	2	7744963
Pubmed	Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.	KMT2D KDM6A	1.85e-05	2	150	2	23184418
Pubmed	Fibrillin microfibrils in bone physiology.	FBN1 FBN2	1.85e-05	2	150	2	26408953
Pubmed	Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration.	FBN1 FBN2	1.85e-05	2	150	2	18006876
Pubmed	Rare variants in FBN1 and FBN2 are associated with severe adolescent idiopathic scoliosis.	FBN1 FBN2	1.85e-05	2	150	2	24833718
Pubmed	Exome sequencing identified new mutations in a Marfan syndrome family.	FBN1 LRP1	1.85e-05	2	150	2	24484584
Pubmed	Nonselective assembly of fibrillin 1 and fibrillin 2 in the rodent ocular zonule and in cultured cells: implications for Marfan syndrome.	FBN1 FBN2	1.85e-05	2	150	2	24265020
Pubmed	In vivo studies of mutant fibrillin-1 microfibrils.	FBN1 FBN2	1.85e-05	2	150	2	20529844
Pubmed	Kabuki syndrome: clinical and molecular diagnosis in the first year of life.	KMT2D KDM6A	1.85e-05	2	150	2	25281733
Pubmed	Fibrillin-1 mutations causing Weill-Marchesani syndrome and acromicric and geleophysic dysplasias disrupt heparan sulfate interactions.	FBN1 FBN2	1.85e-05	2	150	2	23133647
Pubmed	Congenital hyperinsulinism as the presenting feature of Kabuki syndrome: clinical and molecular characterization of 9 affected individuals.	KMT2D KDM6A	1.85e-05	2	150	2	29907798
Pubmed	Kabuki syndrome: expanding the phenotype to include microphthalmia and anophthalmia.	KMT2D KDM6A	1.85e-05	2	150	2	26049589
Pubmed	Linkage of Marfan syndrome and a phenotypically related disorder to two different fibrillin genes.	FBN1 FBN2	1.85e-05	2	150	2	1852206
Pubmed	Absence of deletion and duplication of MLL2 and KDM6A genes in a large cohort of patients with Kabuki syndrome.	KMT2D KDM6A	1.85e-05	2	150	2	22840376
Pubmed	Mutation Update for Kabuki Syndrome Genes KMT2D and KDM6A and Further Delineation of X-Linked Kabuki Syndrome Subtype 2.	KMT2D KDM6A	1.85e-05	2	150	2	27302555
Pubmed	LINGO-1 receptor promotes neuronal apoptosis by inhibiting WNK3 kinase activity.	LINGO1 WNK3	1.85e-05	2	150	2	23482566
Pubmed	Kabuki Syndrome	KMT2D KDM6A	1.85e-05	2	150	2	21882399
Pubmed	Hypermobility in individuals with Kabuki syndrome: The effect of growth hormone treatment.	KMT2D KDM6A	1.85e-05	2	150	2	30556359
Pubmed	Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences.	FBN1 FBN2	1.85e-05	2	150	2	12429739
Pubmed	MLL2 and KDM6A mutations in patients with Kabuki syndrome.	KMT2D KDM6A	1.85e-05	2	150	2	23913813
Pubmed	Fibrillin-1 and fibrillin-2 in human embryonic and early fetal development.	FBN1 FBN2	1.85e-05	2	150	2	12524050
Pubmed	Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup.	TMEM183A TMEM183BP	1.85e-05	2	150	2	16644869
Pubmed	Sex-specific differences in expression of histone demethylases Utx and Uty in mouse brain and neurons.	KDM6A UTY	1.85e-05	2	150	2	18434530
Pubmed	Structure and expression of fibrillin-2, a novel microfibrillar component preferentially located in elastic matrices.	FBN1 FBN2	1.85e-05	2	150	2	8120105
Pubmed	The fibrillinopathies: New insights with focus on the paradigm of opposing phenotypes for both FBN1 and FBN2.	FBN1 FBN2	1.85e-05	2	150	2	35419902
Pubmed	Prenatal and perinatal history in Kabuki Syndrome.	KMT2D KDM6A	1.85e-05	2	150	2	31654559
Pubmed	Different modes of regulation of transcription and pre-mRNA processing of the structurally juxtaposed homologs, Rnf33 and Rnf35, in eggs and in pre-implantation embryos.	TRIM61 TRIM60	1.85e-05	2	150	2	12433986
Pubmed	Fibrillin assembly: dimer formation mediated by amino-terminal sequences.	FBN1 FBN2	1.85e-05	2	150	2	10504303
Pubmed	The phenotypic spectrum of Kabuki syndrome in patients of Chinese descent: A case series.	KMT2D KDM6A	1.85e-05	2	150	2	31883305
Pubmed	SETting up the genome: KMT2D and KDM6A genomic function in the Kabuki syndrome craniofacial developmental disorder.	KMT2D KDM6A	1.85e-05	2	150	2	37800171
Pubmed	Target sequencing and CRISPR/Cas editing reveal simultaneous loss of UTX and UTY in urothelial bladder cancer.	KDM6A UTY	1.85e-05	2	150	2	27533081
Pubmed	Three novel mutations of the fibrillin-1 gene and ten single nucleotide polymorphisms of the fibrillin-3 gene in Marfan syndrome patients.	FBN1 FBN3	1.85e-05	2	150	2	15221638
Pubmed	Kabuki syndrome genes KMT2D and KDM6A: functional analyses demonstrate critical roles in craniofacial, heart and brain development.	KMT2D KDM6A	1.85e-05	2	150	2	25972376
Pubmed	Prenatal Phenotype of Kabuki Syndrome: Seven Case Series.	KMT2D KDM6A	1.85e-05	2	150	2	36436503
Pubmed	Clinical and molecular characterization study of Chinese Kabuki syndrome in Hong Kong.	KMT2D KDM6A	1.85e-05	2	150	2	33314698
Pubmed	Positive and negative selection on mammalian Y chromosomes.	KDM6A UTY	1.85e-05	2	150	2	15758204
Pubmed	Lysine demethylases KDM6A and UTY: The X and Y of histone demethylation.	KDM6A UTY	1.85e-05	2	150	2	31097364
Pubmed	Basement membrane derived fibulin-1 and fibulin-5 function as angiogenesis inhibitors and suppress tumor growth.	FBLN5 FBLN1	1.85e-05	2	150	2	18222970
Interaction	PCDHGA8 interactions	PCDHGA9 PCDHGA5 PCDHGA4 PCDHGA8	1.14e-08	5	141	4	int:PCDHGA8
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L20 USP17L11 PCDHGA2 USP17L19 NCAPH USP17L18 CSF2RA BRCA2 USP17L17 FHL3	2.51e-06	318	141	12	int:FLT3
Interaction	PCDHGA4 interactions	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA8	3.69e-06	34	141	5	int:PCDHGA4
Interaction	MFAP5 interactions	VWF LAMA5 FBLN1 FBN1 FBN2	3.12e-05	52	141	5	int:MFAP5
Interaction	LTBP1 interactions	FBLN5 PCDHGA9 PCDHGA6 PCDHGA5 FBN1 FBN2	4.59e-05	92	141	6	int:LTBP1
Interaction	ZFP41 interactions	FBLN5 FBLN1 FBN1 FBN2 LRP1	4.88e-05	57	141	5	int:ZFP41
Cytoband	4p16.1	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 PSAPL1 USP17L15 USP17L13	1.34e-24	79	150	16	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L23 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 PSAPL1 USP17L15 USP17L13	4.00e-17	222	150	16	chr4p16
Cytoband	5q31	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 FBXL21P PCDHGA8	1.13e-07	115	150	7	5q31
Cytoband	Ensembl 112 genes in cytogenetic band chr5q31	PSD2 PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 FBXL21P PCDHGA8	6.80e-06	298	150	8	chr5q31
Cytoband	22q12.1	TFIP11 ASCC2 MYO18B	1.58e-04	32	150	3	22q12.1
Cytoband	8p11.23	ADGRA2 KCNU1	6.85e-04	12	150	2	8p11.23
GeneFamily	Clustered protocadherins	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	6.25e-07	64	87	6	20
GeneFamily	Zinc fingers MIZ-type	PIAS2 PIAS3	4.73e-04	7	87	2	85
GeneFamily	Fibulins	FBLN5 FBLN1	6.29e-04	8	87	2	556
GeneFamily	Maestro heat like repeat containing	MROH5 MROH1	1.22e-03	11	87	2	636
GeneFamily	Low density lipoprotein receptors	LRP1 LRP5	1.72e-03	13	87	2	634
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD3 SVEP1 SNED1	2.61e-03	57	87	3	1179
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	1.77e-15	86	146	13	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L12 DLL4 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	2.21e-15	112	146	14	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	6.29e-12	160	146	13	MM1155
Coexpression	NABA_CORE_MATRISOME	FBLN5 VWF COL16A1 CRIM1 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 FBN3 OTOG IMPG2	5.16e-09	275	146	13	M5884
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L21 FBLN5 TMEM183A USP17L12 USP17L20 USP17L11 LMTK2 USP17L5 USP17L10 TMEM183BP USP17L19 PIAS2 ADGRA2 SVEP1 USP17L18 PTPRK USP17L17 USP17L6P ASCC2 LRRC28 USP17L22 PCCB KDM6A USP17L15 USP17L13	1.14e-08	1198	146	25	MM1062
Coexpression	NABA_ECM_GLYCOPROTEINS	FBLN5 VWF CRIM1 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 FBN3 OTOG	1.40e-08	196	146	11	M3008
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 USP17L18 PIAS3 USP17L17 CLEC4G USP17L6P RIPOR1 POLK USP17L22 PSAPL1 USP17L15 USP17L13	2.31e-08	647	146	18	MM981
Coexpression	NABA_CORE_MATRISOME	FBLN5 VWF COL16A1 CRIM1 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 OTOG IMPG2	4.05e-08	270	146	12	MM17057
Coexpression	NABA_ECM_GLYCOPROTEINS	FBLN5 VWF CRIM1 LAMA5 SVEP1 SNED1 FBLN1 FBN1 FBN2 OTOG	1.25e-07	191	146	10	MM17059
Coexpression	GAO_LARGE_INTESTINE_ADULT_CJ_IMMUNE_CELLS	FBLN5 VWF OBSCN LAMA5 CSMD3 ADGRA2 RYR3 SNED1 FBLN1 FBN1 TET1 LRP1 RIPOR1	5.34e-06	505	146	13	M39167
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	USP17L21 USP17L12 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 MFRP USP17L18 MLH3 PIAS3 USP17L17 CLEC4G USP17L6P RIPOR1 POLK USP17L22 PSAPL1 USP17L15 USP17L13	1.60e-05	1226	146	20	MM979
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L21 TRADD USP17L12 NCKAP1 USP17L20 USP17L11 USP17L5 USP17L10 USP17L19 FHIP1B USP17L18 PPP2R1A USP17L17 USP17L6P USP17L22 KDM6A USP17L15 USP17L13	3.03e-05	1072	146	18	MM1031
CoexpressionAtlas	DevelopingGonad_e16.5_epididymis_emap-29702_top-relative-expression-ranked_1000	COL16A1 LCORL PARD3B FHIP1B BIRC6 SVEP1 PPP2R1A FBN2 PTPRK TET1 LRP1 SCAF11 KDM6A UTY AHNAK2 ZNF445	2.96e-05	790	131	16	gudmap_developingGonad_e16.5_epididymis_1000
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_k-means-cluster#4_top-relative-expression-ranked_1000	COL16A1 PARD3B MFRP SVEP1 SNED1 PTPRK TET1 LRP1 ZNF445	3.08e-05	256	131	9	gudmap_developingGonad_e14.5_ epididymis_1000_k4
CoexpressionAtlas	DevelopingGonad_e14.5_ epididymis_emap-29141_top-relative-expression-ranked_1000	COL16A1 LCORL PARD3B MFRP FHIP1B BIRC6 SVEP1 SNED1 PPP2R1A PTPRK TET1 LRP1 SCAF11 KDM6A UTY ZNF445	3.50e-05	801	131	16	gudmap_developingGonad_e14.5_ epididymis_1000
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1 ASTN2	1.73e-07	189	142	8	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	COVID-19-kidney-Mito-rich_Int\|kidney / Disease (COVID-19 only), tissue and cell type	THSD7B CSMD3 SVEP1 LINGO1 CNTNAP4 MYO18B FBN3	1.95e-07	129	142	7	57b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1 ASTN2	2.04e-07	193	142	8	fb28717fadd06c3840636d25409ce80c9254bd34
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 SNED1 FBLN1 FBN1 LRP1	2.20e-07	195	142	8	d9a5c75d31c6e8bb1e1ab7fd115ac5deb5fb1c8d
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1 SLC39A14	2.20e-07	195	142	8	f54bc4454270ff06e85596f98199372b50d0179f
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VWF DLL4 RYR3 SNED1 FBN1 OLFM3 GPIHBP1 ST6GALNAC3	2.20e-07	195	142	8	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	LPS-IL1RA+antiTNF-Unknown-Endothelial\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZBED10P RYR3 GPIHBP1 LINGO1 RIPOR1 LRRC28 MYO18B	2.28e-07	132	142	7	46c80eab16a70da9f363a9fbdf50bccab0b287d7
ToppCell	LPS-IL1RA+antiTNF-Unknown\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZBED10P RYR3 GPIHBP1 LINGO1 RIPOR1 LRRC28 MYO18B	2.28e-07	132	142	7	a022c3c41654166cb106f27dc54fa88e8c40f898
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 FBN2 LRP1	2.67e-07	200	142	8	3dacd0afe69bc16bb33336ea9ea99a9cd47731d9
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 LRP1 ASTN2	1.84e-06	180	142	7	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 LRP1 ASTN2	1.84e-06	180	142	7	9b1de1b4711adbf9a423f4d2d08f3f4c78f1f8f4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 TMEM190 ADGRA2 SVEP1 FBLN1 LRP1	1.91e-06	181	142	7	6d1f1ad35778a2a227f966f11f6edd8e89452576
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1 PCDHGA8	1.91e-06	181	142	7	c6d2a13df3b74fade3b0c71e285b4c14c8e52413
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1 PCDHGA8	1.91e-06	181	142	7	c62b0a2422377ffadaab63edd538e87a06fa5017
ToppCell	droplet-Liver-nan-3m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRIM1 NCKAP1 DLL4 PARD3B ADGRA2 GPIHBP1 CLEC4G	2.06e-06	183	142	7	709a486154b3157427deb3b8886b63ac39ea42dd
ToppCell	droplet-Liver-nan-3m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRIM1 NCKAP1 DLL4 PARD3B ADGRA2 GPIHBP1 CLEC4G	2.06e-06	183	142	7	dc06f19f6f80f4c7f13f1f990c1fe0f91ba64ea7
ToppCell	metastatic_Brain-Endothelial_cells-Stalk-like_ECs\|metastatic_Brain / Location, Cell class and cell subclass	FBLN5 PSD2 VWF CRIM1 DLL4 GPIHBP1 ST6GALNAC3	2.21e-06	185	142	7	ad52970e88e8947ef256095bd4b40229b912d58a
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 FBN2 LRP1	2.29e-06	186	142	7	94d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 NUF2 NCAPH ADGRA2 SVEP1 FBN1 BRCA2	2.37e-06	187	142	7	e41e39fd3791acf8ae5376cc5061e196d96868ae
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Cycling_Myofibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 NUF2 NCAPH ADGRA2 SVEP1 FBN1 BRCA2	2.37e-06	187	142	7	cefa211ef224e803ea9467882e2ca74d0b1492f1
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	2.55e-06	189	142	7	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	2.55e-06	189	142	7	d531399749409d614adca13d181830c6e3287508
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 LRP1	2.73e-06	191	142	7	39092a0aff8097617820c59f5fea9ee2bb4f63a2
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 LRP1	2.73e-06	191	142	7	ee5f1b1c59029c46cbb1a00935c03b9317bb9da9
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 COL16A1 RET SVEP1 FBLN1 FBN1 LRP1	2.82e-06	192	142	7	671d4e1eee5aba03c43dbc98f4b51ce42b3df5d5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 LRP1	2.82e-06	192	142	7	d3c1ad4667a1e223a83ca0fcd5991a0b96f1199a
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 COL16A1 RET SVEP1 FBLN1 FBN1 LRP1	2.82e-06	192	142	7	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	2.82e-06	192	142	7	dcd924d6eb67d33ee9f5d3e8ab6e1d4283d6b708
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	FBLN5 VWF SVEP1 SNED1 FBN1 ST6GALNAC3 LRP1	2.82e-06	192	142	7	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	facs-Heart-LV-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 COL16A1 RET SVEP1 FBLN1 FBN1 LRP1	2.82e-06	192	142	7	840a34c1b82d218be999ab5e1bcafd6370d7a4b1
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRIM1 DLL4 PARD3B ADGRA2 GPIHBP1 ST6GALNAC3 CLEC4G	2.92e-06	193	142	7	826b8dd801298b3e0cd76232feae5a14026b8806
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 LRP1	2.92e-06	193	142	7	f1199518c3626fd29bfce65070dd21a660671213
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1 FHL3	2.92e-06	193	142	7	dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRIM1 DLL4 PARD3B ADGRA2 GPIHBP1 ST6GALNAC3 CLEC4G	2.92e-06	193	142	7	87d3a577d37fb0cb4b6313c596310de452bc3872
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 RYR3 SNED1 FBN1 OLFM3 GPIHBP1 ST6GALNAC3	2.92e-06	193	142	7	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	droplet-Liver-LIVER_HEP-30m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CRIM1 DLL4 PARD3B ADGRA2 GPIHBP1 ST6GALNAC3 CLEC4G	2.92e-06	193	142	7	d485634c564b268e344b6a2863c26f6adaec9e38
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1 FHL3	2.92e-06	193	142	7	e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.02e-06	194	142	7	60622bd2f75bfe4c37f721cb12f03dab33f2f58d
ToppCell	LA-02._Fibroblast_II\|LA / Chamber and Cluster_Paper	FBLN5 PARD3B SVEP1 SNED1 FBLN1 FBN1 LRP1	3.02e-06	194	142	7	234d1494c114cce77c619708bbcd8d5ce805f19b
ToppCell	LA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	FBLN5 PARD3B SVEP1 SNED1 FBLN1 FBN1 LRP1	3.13e-06	195	142	7	a78b605b49acd8c9d68716266ca269dafcd910b9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 LRP1	3.13e-06	195	142	7	edd4cd8402af81737b2074f9dce71cc6ab09be7e
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1 AHNAK2	3.13e-06	195	142	7	47762d9e442fb1f6f0033e3e10f4c6e498d2c081
ToppCell	facs-Lung-nan-3m-Endothelial\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NCKAP1 DLL4 BTBD3 SNED1 PTPRK LRP5 RIPOR1	3.13e-06	195	142	7	7f9b7f15006610ad591063d90e90367bd6083c7f
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 LRP1	3.24e-06	196	142	7	525d6c8a277364e624e7cc586275f8a891436b57
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.24e-06	196	142	7	a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.24e-06	196	142	7	3e6803587d8566fd08cb8b290be3b6461743d79c
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1 SLC39A14	3.35e-06	197	142	7	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.35e-06	197	142	7	6d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.35e-06	197	142	7	b349f8e96d61a4c296af64711e11fc44459a9413
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.35e-06	197	142	7	c2e390653d5dee7e731c1840cfdab41987dede9b
ToppCell	COVID-19-lung-Fibroblast\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.46e-06	198	142	7	3ec01a55ade5e1627258cc3cfebb2c3207a4cb43
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	FBLN5 PARD3B SVEP1 SNED1 FBLN1 FBN1 SLC39A14	3.46e-06	198	142	7	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Mesenchymal\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 FBN2 LRP1	3.58e-06	199	142	7	84545ced0c792bc77980a50d65e484eab648d47e
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 SLC39A14	3.58e-06	199	142	7	f835e7ffe976843b0edbf695762d463da85793f3
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_myofibroblast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	FBLN5 COL16A1 ADGRA2 SVEP1 SNED1 FBLN1 FBN1	3.58e-06	199	142	7	21335475bbfbad8a6943b8076a6c1c67f3eec5d3
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1 SLC39A14	3.58e-06	199	142	7	993fa050a095017135a6e723c77cd38b9d782e58
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	FBLN5 VWF NCKAP1 DLL4 AZIN1 FBN1 CNTNAP4	3.70e-06	200	142	7	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL16A1 ADGRA2 SVEP1 FBLN1 FBN1 FBN2 LRP1	3.70e-06	200	142	7	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	367C-Fibroblasts-Fibroblast-D-\|367C / Donor, Lineage, Cell class and subclass (all cells)	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1	1.02e-05	154	142	6	dd3d34f065820e706515a13619f19a5b12734c8e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPATA3 COL16A1 GPR174 CLEC4G LRP1 MYO18B	1.02e-05	154	142	6	5ed64bbf603290e6dc34f81d145982690b89dd0d
ToppCell	367C-Fibroblasts-Fibroblast-D\|367C / Donor, Lineage, Cell class and subclass (all cells)	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1	1.02e-05	154	142	6	4bfda1c41efbb86d829b3797d1168bf2587c3c97
ToppCell	E16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1\|E16.5-samps / Age Group, Lineage, Cell class and subclass	FBLN5 PCDHGA6 SVEP1 RYR3 FBN1 LRP1	1.40e-05	163	142	6	f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell	Adult-Mesenchymal-chondrocyte-D231\|Adult / Lineage, Cell type, age group and donor	COL16A1 DLL4 SVEP1 SNED1 FBLN1 FBN1	1.45e-05	164	142	6	2ba57dce5f69a88f0d1e450b9780425e2d9ca7d4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Glomerular_Capillary_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DLL4 SNED1 GPIHBP1 KCNU1 ST6GALNAC3 ANKS1A	1.72e-05	169	142	6	987ff79ad563825dd9877ea8ccb536758f8c6700
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 DRICH1 ADGRA2 SVEP1 SNED1 FBLN1	1.90e-05	172	142	6	1ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCell	343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	TRIM61 NUF2 ZBED10P NCAPH BRCA2 RAB11FIP3	1.90e-05	172	142	6	e9b97f37bb1732ad9aa89c5e9b513d14022801ac
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PCDHGA5 SVEP1 SNED1 FBLN1 FBN1 LRP1	1.90e-05	172	142	6	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 DRICH1 ADGRA2 SVEP1 SNED1 FBLN1	1.90e-05	172	142	6	ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	FBLN5 VWF AZIN1 RASEF SMPD3 SLC39A14	1.97e-05	173	142	6	4968712af1cca8c932abd3323631d7dcaffd4a66
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 SVEP1 SNED1 FBLN1 LRP1 ASTN2	2.54e-05	181	142	6	9e7d0f1afb8d9bc5a209ddb5314df3a25a0274d9
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1	2.62e-05	182	142	6	b7d532feb73167e05475855061b35a209583f44c
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1	2.62e-05	182	142	6	af65f0fc3f9e5d9ce69ee5faaf5b6cb7f8412e0c
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 VWF CRIM1 DLL4 BTBD3 AZIN1	2.70e-05	183	142	6	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN CSMD3 RYR3 FBN2 CNTNAP4 OTOG	2.78e-05	184	142	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1	2.78e-05	184	142	6	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN CSMD3 RYR3 FBN2 CNTNAP4 OTOG	2.78e-05	184	142	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN CSMD3 RYR3 FBN2 CNTNAP4 OTOG	2.78e-05	184	142	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	COVID-19-Heart-Fib_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBLN5 SVEP1 SNED1 FBLN1 FBN1 LRP1	2.87e-05	185	142	6	8f95d8e591bf7379d13f5a0545b0cb49e2b1ab5d
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell-D231\|Adult / Lineage, Cell type, age group and donor	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 FBN1	2.87e-05	185	142	6	fb6bd7e849ecf4ed9cd9c4e2a946a2d12d62f804
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	PARD3B PTPRK LRP1 SLC39A14 PPP6R2 RAB11FIP3	2.87e-05	185	142	6	1d874608aa2062024323512f68889219471b2f00
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 SVEP1 FBLN1 FBN1 FBN2 LRP1	2.87e-05	185	142	6	785c55d39909fac74415f24427979691e7e694e6
ToppCell	droplet-Kidney-KIDNEY-1m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL16A1 SVEP1 FBLN1 FBN1 FBN2 LRP1	2.87e-05	185	142	6	97a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCell	Control-Myeloid-MoAM3,_VCAN\|Myeloid / Condition, Lineage and Cell class	RYR3 FBN2 METTL9 ST6GALNAC3 CLEC4G FHL3	2.96e-05	186	142	6	0bf16ac48931b62bb3c33d63ff4279654148e293
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL16A1 SVEP1 FBLN1 FBN1 LRP1 AHNAK2	3.14e-05	188	142	6	c32d023a69b6da79687ff8fa7485e7499db57046
ToppCell	-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	SPATA3 COL16A1 SVEP1 FBLN1 FBN1 SLC39A14	3.14e-05	188	142	6	038f48e8daaeb72716e975d22a6b004a90654960
ToppCell	COVID-19-Heart-Fib_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FBLN5 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.14e-05	188	142	6	fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCell	Control-Fibroblasts-Adventitial_FB\|Control / group, cell type (main and fine annotations)	COL16A1 SVEP1 FBLN1 FBN1 LRP1 SLC39A14	3.14e-05	188	142	6	706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL16A1 SVEP1 FBLN1 FBN1 LRP1 AHNAK2	3.14e-05	188	142	6	1cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1	3.23e-05	189	142	6	71397e993a77d70b2eeede240bdfc7660b558987
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 ADGRA2 SVEP1 FBLN1 FBN1	3.23e-05	189	142	6	4eea4759520c312bd17a681034d8074e47093d2b
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 SVEP1 FBLN1 FBN1 LRP1 SMPD3	3.23e-05	189	142	6	bc54ffd7bd1627a36747a80ce5139e4a69928400
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	FBLN5 VWF DLL4 FBN1 ST6GALNAC3 PWWP3B	3.23e-05	189	142	6	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	COL16A1 SVEP1 FBLN1 FBN1 LRP1 PWWP3B	3.23e-05	189	142	6	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Artery\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	FBLN5 VWF DLL4 FBN1 GPIHBP1 CNTNAP4	3.33e-05	190	142	6	aed65d584ca0c25f6a8313c66b421a6618af82ea
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 SVEP1 FBLN1 FBN1 LRP1 SMPD3	3.33e-05	190	142	6	f3ca94a31a35eed5fecf3c4b8c957e1bc4150158
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBLN5 SVEP1 FBLN1 FBN1 LRP1 SMPD3	3.33e-05	190	142	6	c2cd1eb674162ee40502c3380b7245c85079c7ce
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 FBLN1 FBN1 LRP1	3.43e-05	191	142	6	a58c75e9580139fb370b498d95660f10f3a2a27b
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FBLN5 COL16A1 SVEP1 SNED1 FBLN1 LRP1	3.43e-05	191	142	6	a6c57627077fa980b7ec1d3894b5f31bfb11b738
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	COL16A1 SVEP1 SNED1 FBLN1 FBN1 LRP1	3.43e-05	191	142	6	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	VWF DLL4 RYR3 FBN1 OLFM3 ST6GALNAC3	3.43e-05	191	142	6	b2c86cde341fe350143658c8a8a4a9edbce3f19b
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.83e-22	46	146	14	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 USP17L12 USP17L20 USP17L11 USP17L24 USP17L5 USP17L10 USP17L19 USP17L18 KMT2D USP17L17 USP17L6P USP17L22 USP17L15 USP17L13	5.63e-21	69	146	15	DOID:1682 (implicated_via_orthology)
Disease	mental development measurement	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	2.17e-09	25	146	6	EFO_0008230
Disease	Sarcosine measurement	PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	8.67e-08	23	146	5	EFO_0021668
Disease	Kabuki syndrome (implicated_via_orthology)	KMT2D KDM6A UTY	1.19e-07	3	146	3	DOID:0060473 (implicated_via_orthology)
Disease	connective tissue disease (implicated_via_orthology)	FBN1 FBN2 FBN3	1.19e-07	3	146	3	DOID:65 (implicated_via_orthology)
Disease	childhood trauma measurement, alcohol consumption measurement	PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 PCDHGA8	1.45e-06	71	146	6	EFO_0007878, EFO_0007979
Disease	Kabuki syndrome 1	KMT2D KDM6A	2.43e-05	2	146	2	cv:CN030661
Disease	Kabuki syndrome (is_implicated_in)	KMT2D KDM6A	2.43e-05	2	146	2	DOID:0060473 (is_implicated_in)
Disease	KABUKI SYNDROME 1	KMT2D KDM6A	2.43e-05	2	146	2	147920
Disease	esophagus squamous cell carcinoma (is_implicated_in)	AZIN1 KMT2D BRCA2 KDM6A	7.32e-05	45	146	4	DOID:3748 (is_implicated_in)
Disease	cognitive function measurement	CRIM1 DLL4 LCORL PCDHGA5 MACROD1 PARD3B THSD7B CSMD3 ADGRA2 BIRC6 RYR3 KMT2D LINGO1 ST6GALNAC3 TTC21B CNTNAP4 MYO18B PCCB GABPA	8.87e-05	1434	146	19	EFO_0008354
Disease	Kabuki make-up syndrome	KMT2D KDM6A	1.45e-04	4	146	2	C0796004
Disease	microphthalmia (is_implicated_in)	MFRP LRP5	1.45e-04	4	146	2	DOID:10629 (is_implicated_in)
Disease	scoliosis (is_implicated_in)	FBN1 FBN2	1.45e-04	4	146	2	DOID:0060249 (is_implicated_in)
Disease	response to antineoplastic agent, response to doxorubicin	PCDHGA5 LINGO1	3.60e-04	6	146	2	GO_0097327, GO_1902520
Disease	verbal-numerical reasoning measurement	COL16A1 DLL4 LCORL BIRC6 FBN3	5.00e-04	131	146	5	EFO_0008394
Disease	Common Migraine	LRP1 ASTN2	5.02e-04	7	146	2	C0338480
Disease	Large cell carcinoma of lung	LMTK2 MYO18B WNK3	5.30e-04	32	146	3	C0345958
Disease	mean platelet volume	VWF PCDHGA9 PCDHGA6 PCDHGA5 PCDHGA4 PCDHGA2 DDO LRCH1 SVEP1 AZIN1 RIPOR1 PCDHGA8 ANKS1A RAB11FIP3	5.60e-04	1020	146	14	EFO_0004584
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	VWF FBN1	6.68e-04	8	146	2	DOID:4783 (biomarker_via_orthology)
Disease	peak expiratory flow	PCDHGA5 LINGO1 PTPRK LRP1 LRP5 ASTN2 PPP6R2 FBN3 ANKS1A	8.69e-04	498	146	9	EFO_0009718
Disease	aortic aneurysm	FBN1 LRP1	1.07e-03	10	146	2	EFO_0001666
Disease	cystic kidney disease (implicated_via_orthology)	LAMA5 TTC21B	1.07e-03	10	146	2	DOID:2975 (implicated_via_orthology)
Disease	vital capacity	CRIM1 LCORL POLR2B AP3B1 SVEP1 ADAMTS18 ASTN2 RIPOR1 MYO18B FHL3 PPP6R2 NLRP4 FBN3 OTOG ANKS1A	1.24e-03	1236	146	15	EFO_0004312
Disease	Microphthalmos	MFRP KMT2D	1.30e-03	11	146	2	C0026010
Disease	Machado-Joseph disease, age at onset	THSD7B LRRC28	1.30e-03	11	146	2	EFO_0004847, MONDO_0007182
Disease	pulse pressure measurement	FBLN5 CRIM1 NCKAP1 LCORL LAMA5 LRCH1 SVEP1 TRAK1 FBN1 FBN2 OLFM3 TET1 TBC1D12 LRP1 ASCC2 FHL3	1.50e-03	1392	146	16	EFO_0005763
Disease	microphthalmia (implicated_via_orthology)	CRIM1 MFRP	1.55e-03	12	146	2	DOID:10629 (implicated_via_orthology)
Disease	hematologic cancer (implicated_via_orthology)	PIAS2 PIAS3	1.83e-03	13	146	2	DOID:2531 (implicated_via_orthology)
Disease	birth weight, pelvic organ prolapse	AP3B1 FBN2 POM121L12	1.85e-03	49	146	3	EFO_0004344, EFO_0004710
Disease	forced expiratory volume	CRIM1 LCORL PCDHGA5 PARD3B AP3B1 SVEP1 ASCC2 LRP5 ASTN2 PPP6R2 ANKS1A	1.95e-03	789	146	11	EFO_0004314
Disease	cognitive function measurement, self reported educational attainment	DLL4 LCORL THSD7B BIRC6 TTC21B CNTNAP4 PCCB	2.00e-03	355	146	7	EFO_0004784, EFO_0008354
Disease	glycerate measurement	THSD7B RYR3	2.45e-03	15	146	2	EFO_0021029
Disease	migraine without aura, susceptibility to, 4	LRP1 ASTN2	2.79e-03	16	146	2	MONDO_0011847
Disease	alcohol use disorder (implicated_via_orthology)	PSD2 RYR3 KCNU1 KDM6A UTY	2.91e-03	195	146	5	DOID:1574 (implicated_via_orthology)
Disease	platelet component distribution width	VWF DLL4 LAMA5 DDO ZFPM1 LRCH1 SVEP1 POLK ANKS1A RAB11FIP3	4.45e-03	755	146	10	EFO_0007984
Disease	central corneal thickness	CRIM1 FBN1 FBN2 ST6GALNAC3 ADAMTS18 PCCB	4.48e-03	309	146	6	EFO_0005213
Disease	Antimigraine preparation use measurement	LRP1 ASTN2	4.80e-03	21	146	2	EFO_0009939

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDPLRSCCLVAADAQ	TBC1D12	196	O60347
QDDPDSCLRQCALLL	TTC21B	931	Q7Z4L5
ECPEVRLNIISNLDC	PPP2R1A	376	P30153
TTLRCCLSPEENAED	BTN2A3P	46	Q96KV6
FRDNPSELCCIIVDS	ACTR6	136	Q9GZN1
SQCENSADEPQCLLL	ANAPC2	96	Q9UJX6
DVEESQCLRLCPFLE	BIRC6	1161	Q9NR09
VCQVLCPANELRLDS	CSMD3	2451	Q7Z407
SLQEAQLCCEGALEL	ADGRA2	231	Q96PE1
PSCDELDQIVESCLL	AZIN1	356	O14977
TRCFCLEEPQNSEVD	COL16A1	276	Q07092
PLLAACDVRCQSITD	ASB10	251	Q8WXI3
CLLPILESSCDNIQG	ASCC2	331	Q9H1I8
DLQIDSCGISDRCLP	CNTNAP4	541	Q9C0A0
CELELSECDSNPCRN	DLL4	321	Q9NR61
CVLLSQSCLFEEPDL	BTBD3	226	Q9Y2F9
DPDCVDRLLQCTRQA	API5	231	Q9BZZ5
IRNISCAAQDPEDLC	ANKS1A	1006	Q92625
DAPCSDLAQELRQSC	DFFA	151	O00273
LACDLLPCNSDLRDL	ANKRD39	166	Q53RE8
DIDECSLNPLLCAFR	FBN3	2166	Q75N90
RDLCGQRTTDACEQL	ASTN2	511	O75129
QRTTDACEQLCDPET	ASTN2	516	O75129
KPNLDLEETCNRRAC	ADAMTS18	1101	Q8TE60
TCLNGLVCLLSNRDE	AP3B1	441	O00203
DREELCAQSAPCLLN	PCDHGA2	91	Q9Y5H1
DCDSLALCDPLQRTN	RASEF	411	Q8IZ41
ALCDPLQRTNCEVDS	RASEF	416	Q8IZ41
LQRTNCEVDSLPESC	RASEF	421	Q8IZ41
LDEENSELRSCTPCL	RAB11FIP3	551	O75154
CQEDDVRLLCHLTPS	INTS3	731	Q68E01
LQQPAANLSELCRSC	KAT2A	136	Q92830
DREELCAQSPLCVVN	PCDHGA5	91	Q9Y5G8
DREELCAQSPRCLIN	PCDHGA8	91	Q9Y5G5
RCDQLICLLPDSVCD	MFRP	266	Q9BY79
IDREELCDRSPNCVT	PCDHGA4	121	Q9Y5G9
LCDRSPNCVTNLEIL	PCDHGA4	126	Q9Y5G9
SQLCVCVAQEPSLLE	FHIP1B	181	Q8N612
EPDCCALSLETSEQL	PARD3B	481	Q8TEW8
DREELCAQSPRCLVS	PCDHGA6	91	Q9Y5G7
EEEDLTLQPRSCLQC	OAZ3	61	Q9UMX2
LPRDERCNLTQNCSH	GPIHBP1	71	Q8IV16
EPRLQCSLDAHEICL	GABPA	56	Q06546
VRTCPLDEFQCNNTL	LRP1	3651	Q07954
FCNLQREAVSDCIPS	LCORL	91	Q8N3X6
RSDEADCDAICLPNQ	LRP5	1326	O75197
QLALVDCNPCTLSNA	KDM6A	191	O15550
SSLQEDRSCPQLELC	HMGXB3	136	Q12766
ESCRLIEALSSCQLP	MLH3	1376	Q9UHC1
DSVDCLPSCQLEVQL	NUF2	281	Q9BZD4
DREELCAQSPRCLVN	PCDHGA9	91	Q9Y5G4
AEDDPSRTLCEACNI	ZFPM1	676	Q8IX07
LACDDRRPNSICQLV	OR56B1	196	Q8NGI3
ESCPICLNAFRDQAV	PHRF1	106	Q9P1Y6
ADLCSPCDILQLDFR	LRCH1	661	Q9Y2L9
ISCLNLLDRCDQPLT	METTL9	206	Q9H1A3
SCLEARKSQPDESCL	LMTK2	1151	Q8IWU2
LETLILDSNPLACDC	LINGO1	361	Q96FE5
ESAEACLIIANPLCS	KCNU1	406	A8MYU2
NCLTQLPDVVCELSL	LRRC10	131	Q5BKY1
NQLDTGVPLLCEALC	NLRP4	761	Q96MN2
SEQRPLQATACECLR	AP5B1	141	Q2VPB7
VALCLASLNSCLDPV	GPR174	276	Q9BXC1
LEALCRQDNSLPRPC	LAMA5	1061	O15230
CRLLQEDSSPLLRCA	DDX41	281	Q9UJV9
DPLVQEQVCSALCSL	MROH1	21	Q8NDA8
RQRADDPCCLQLLCT	SMPD3	46	Q9NY59
DPCTRETLLGALSQC	POM121L12	171	Q8N7R1
LSRECCEELNLRPDC	HELZ	571	P42694
DICTEQCTLSDQLLP	NCKAP1	616	Q9Y2A7
EALVDECCLLPSQLL	MED16	711	Q9Y2X0
PDAENSREILSRCCA	DDO	246	Q99489
SLEQETGDIARLCCQ	OBSCN	4076	Q5VST9
IQPSSTRARICCDLD	PCCB	506	P05166
DALGNCIDINECLSI	FBLN1	301	P23142
PLCEECTDSLLEQLD	BECN2	116	A8MW95
CQRSLADEPFTCQDS	FHL3	71	Q13643
QADDVSCPLLNSCLS	BRCA2	126	P51587
RNCTDIDECRISPDL	FBN1	1066	P35555
LSPNISACIDINECE	FBN1	1146	P35555
SELSTLCANSCPDER	CHMP7	181	Q8WUX9
PREQSCELSTCRQQL	CEP85	276	Q6P2H3
LTDAQNCEICECRPR	CRIM1	521	Q9NZV1
AGPLLTDECRTLQSC	MACROD1	191	Q9BQ69
QSGQCLDIDECRTIP	FBLN5	36	Q9UBX5
RNCTDIDECRISPDL	FBN2	1111	P35556
LSPSREDCVDINECS	FBN2	1191	P35556
SEADRCPICLNCLLE	SCAF11	36	Q99590
EFCPTILQQLDSRAC	SLC39A14	116	Q15043
NRLREECPLDTSLCT	MENT	256	Q9BUN1
ICTVVAPEQNLCSRD	OLFM3	66	Q96PB7
EPRLSNNECSCTFRE	CSF2RA	71	P15509
NLSLVCLPRSEDDDC	DRICH1	151	Q6PGQ1
ACELLTCDVPQISDR	PPP6R2	81	O75170
RLQAEDCSIACLPRN	PTPRK	1186	Q15262
LRLCLAETSCPQEDN	PIAS2	211	O75928
SFLCRLCCQEDPELD	KCTD2	96	Q14681
LDTQADLCVPRNQCS	OTOG	831	Q6ZRI0
LCEAELVPSCRQDQI	OTOG	2546	Q6ZRI0
FCDIPQLLAISCSEN	OR14A16	176	Q8NHC5
AAECEPLNCELSERS	MINAR1	131	Q9UPX6
LCQDPDRATQRCSLE	MROH5	641	Q6ZUA9
CANDLQPLDNELICI	FBXL21P	346	Q9UKT6
LIDCNPCTLSNAEIQ	UTY	191	O14607
AQVCTALSLCEPLQR	PSAPL1	131	Q6NUJ1
DEERCLSCILAQQPD	TRADD	131	Q15628
QCLDLSDNALEIVCP	LRRC28	91	Q86X40
LPGCLEERENSACLL	PWWP3B	141	Q5H9M0
TNPDQDCCLLQVTTL	TMEM183BP	286	Q1AE95
LTDRDLCELNECPLD	POLR2B	166	P30876
EPLQLDCDLCAIVSN	ST6GALNAC3	71	Q8NDV1
EIRRSSCCLLSPDAN	SPATA3	76	Q8NHX4
EERPCQSLCDLQPDF	IMPG2	1046	Q9BZV3
RSDQQCLAVSCDEPP	SVEP1	2011	Q4LDE5
SEPPQCLEIDECRSQ	SNED1	746	Q8TER0
DSELPTCSCLDRVIQ	TET1	1416	Q8NFU7
REVQCPEANIDTALC	AHNAK2	5411	Q8IVF2
QADCRQALPLLASAC	CIAO3	176	Q9H6Q4
ALEAVRLQNNSCEPC	CLEC4G	151	Q6UXB4
LQQCAEDRQICPSLA	NCAPH	306	Q15003
RTNACDVCNSTDLPE	TRAK1	26	Q9UPV9
QLRFCLCETSCPQED	PIAS3	191	Q9Y6X2
ALADLRAEASCPICL	TRIM61	6	Q5EBN2
RNCCLTLCNFSIPEE	ZER1	456	Q7Z7L7
QAAIDSPNLCLRLRC	TMEM190	46	Q8WZ59
TNPDQDCCLLQVTTL	TMEM183A	286	Q8IXX5
RTATLCPQSCEERNL	VWF	1121	P04275
LLPSCTTRLCQEEQL	PSD2	646	Q9BQI7
PDLCVCNFVLEQSLS	RYR3	61	Q15413
SPLSCETRVDLCDDL	USP17L18	41	D6R9N7
EISENSDDCQILTCP	POLK	611	Q9UBT6
SPLSCETRVDLCDDL	USP17L5	41	A8MUK1
SPLSCETRVDLCDDL	USP17L21	41	D6R901
SPLSCETRVDLCDDL	USP17L13	41	C9JLJ4
IQLAEGLARQLCTDC	ZBED10P	46	Q96FA7
SPLSCETRVDLCDDL	USP17L19	41	D6RCP7
ALVNLQEESSCPICL	TRIM60	6	Q495X7
SSALRTCEQPLQCEI	MYO18B	1071	Q8IUG5
QDPLCDELCRTVIAA	RET	626	P07949
SPLSCETRVDLCDDL	USP17L12	41	C9JPN9
PLEDCKEACSQSSRL	ZNF445	951	P59923
SPLSCETRVDLCDDL	USP17L24	41	Q0WX57
PLCQLDCGSREQLIA	ZNF821	121	O75541
SPLSCETRVDLCDDL	USP17L6P	41	Q6QN14
QCPNLTESRACDAPI	THSD7B	216	Q9C0I4
SPLSCETRVDLCDDL	USP17L22	41	D6RA61
DQCTERLSCFLCPVE	RIPOR1	976	Q6ZS17
SPLSCETRVDLCDDL	USP17L15	41	C9J2P7
SPLSCETRVDLCDDL	USP17L17	41	D6RBQ6
CSNPLTLDECARIFE	TFIP11	391	Q9UBB9
SPLSCETRVDLCDDL	USP17L23	41	D6RBM5
SPLSCETRVDLCDDL	USP17L20	41	D6RJB6
ALTCSLPKNEDLCLN	ZFYVE16	301	Q7Z3T8
SPLSCETRVDLCDDL	USP17L10	41	C9JJH3
DPCVQDPQDRESLSC	ZNF311	121	Q5JNZ3
SPLSCETRVDLCDDL	USP17L11	41	C9JVI0
SCLINELENPLCVES	WNK3	1616	Q9BYP7
ELENPLCVESNAASC	WNK3	1621	Q9BYP7
EVCGQASDPSRLLLC	KMT2D	1431	O14686