Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncoumarin 7-hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

1.22e-083473GO:0008389
GeneOntologyMolecularFunctionarachidonate epoxygenase activity

CYP2A6 CYP2A7 CYP2A13

2.39e-0524473GO:0008392
GeneOntologyMolecularFunctionarachidonate monooxygenase activity

CYP2A6 CYP2A7 CYP2A13

3.44e-0527473GO:0008391
GeneOntologyMolecularFunctionL-lactate dehydrogenase activity

LDHAL6B LDHAL6A

5.40e-055472GO:0004459
GeneOntologyMolecularFunctionsteroid hydroxylase activity

CYP2A6 CYP2A7 CYP2A13

6.95e-0534473GO:0008395
GeneOntologyMolecularFunctionaromatase activity

CYP2A6 CYP2A7 CYP2A13

7.59e-0535473GO:0070330
GeneOntologyMolecularFunctionlactate dehydrogenase activity

LDHAL6B LDHAL6A

8.09e-056472GO:0004457
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

CYP2A6 CYP2A7 CYP2A13

2.09e-0449473GO:0016712
GeneOntologyMolecularFunctiontranscription coactivator binding

HNF1A MED1 CIT

2.79e-0454473GO:0001223
GeneOntologyMolecularFunctiontranscription coregulator binding

HNF1A HNF1B MED1 CIT

3.27e-04140474GO:0001221
GeneOntologyMolecularFunctionnuclear vitamin D receptor binding

NCOA6 MED1

8.10e-0418472GO:0042809
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

NCOA6 MED1

1.11e-0321472GO:0042975
GeneOntologyMolecularFunctionmonooxygenase activity

CYP2A6 CYP2A7 CYP2A13

2.51e-03115473GO:0004497
GeneOntologyMolecularFunctionnuclear thyroid hormone receptor binding

NCOA6 MED1

2.90e-0334472GO:0046966
GeneOntologyBiologicalProcessphenylpropanoid metabolic process

CYP2A6 CYP2A7 CYP2A13

1.32e-0610473GO:0009698
GeneOntologyBiologicalProcesscoumarin metabolic process

CYP2A6 CYP2A7 CYP2A13

1.32e-0610473GO:0009804
GeneOntologyBiologicalProcessregulation of pronephros size

HNF1A HNF1B

5.08e-062472GO:0035565
GeneOntologyBiologicalProcesspronephros morphogenesis

HNF1A HNF1B

1.52e-053472GO:0072114
GeneOntologyBiologicalProcessepoxygenase P450 pathway

CYP2A6 CYP2A7 CYP2A13

1.66e-0522473GO:0019373
GeneOntologyBiologicalProcesschordate embryonic development

STK3 HOXB3 NCOA6 HNF1A HNF1B COL11A1 PAX7 MAN2A1 MED1 CECR2

3.00e-059064710GO:0043009
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

STK3 HOXB3 NCOA6 HNF1A HNF1B COL11A1 PAX7 MAN2A1 MED1 CECR2

3.71e-059294710GO:0009792
GeneOntologyBiologicalProcessglycoprotein metabolic process

NPC1 COL11A1 ACOT8 FUT2 MAN2A1 MGAT5B TUSC3

4.99e-05430477GO:0009100
GeneOntologyBiologicalProcessembryonic hemopoiesis

STK3 LDB1 MED1

5.25e-0532473GO:0035162
GeneOntologyBiologicalProcessregulation of kidney size

HNF1A HNF1B

7.58e-056472GO:0035564
GeneOntologyBiologicalProcessliver development

NPC1 HNF1A HNF1B MAN2A1 MED1

9.42e-05202475GO:0001889
GeneOntologyBiologicalProcesshepaticobiliary system development

NPC1 HNF1A HNF1B MAN2A1 MED1

1.01e-04205475GO:0061008
GeneOntologyBiologicalProcessglycoprotein biosynthetic process

NPC1 ACOT8 FUT2 MAN2A1 MGAT5B TUSC3

1.52e-04357476GO:0009101
GeneOntologyBiologicalProcesslong-chain fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 ACOT8

1.82e-04124474GO:0001676
GeneOntologyBiologicalProcessembryonic morphogenesis

STK3 HOXB3 HNF1A HNF1B COL11A1 LDB1 MED1 CECR2

1.87e-04713478GO:0048598
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

CYP2A6 CYP2A7 CYP2A13 ACOT8

2.05e-04128474GO:0033559
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

NPC1 LDHAL6B CYP2A6 CYP2A7 HNF1A CYP2A13 ACOT8 LDHAL6A

2.21e-04731478GO:0032787
GeneOntologyBiologicalProcessregulation of vitamin D receptor signaling pathway

MED1 MN1

2.26e-0410472GO:0070562
GeneOntologyBiologicalProcesspronephros development

HNF1A HNF1B

2.26e-0410472GO:0048793
GeneOntologyBiologicalProcessheme metabolic process

CYP2A6 HNF1A CYP2A13

2.54e-0454473GO:0042168
GeneOntologyBiologicalProcessembryonic organ development

STK3 HOXB3 NCOA6 HNF1B COL11A1 LDB1 MED1

2.60e-04561477GO:0048568
GeneOntologyBiologicalProcessmacromolecule glycosylation

NPC1 FUT2 MAN2A1 MGAT5B TUSC3

2.64e-04252475GO:0043413
GeneOntologyBiologicalProcessprotein glycosylation

NPC1 FUT2 MAN2A1 MGAT5B TUSC3

2.64e-04252475GO:0006486
GeneOntologyBiologicalProcessbile acid metabolic process

NPC1 HNF1A ACOT8

2.68e-0455473GO:0008206
GeneOntologyBiologicalProcessembryo development

STK3 HOXB3 NCOA6 HNF1A HNF1B COL11A1 PAX7 MAN2A1 LDB1 MED1 CECR2

3.05e-0414374711GO:0009790
GeneOntologyBiologicalProcessvitamin D receptor signaling pathway

MED1 MN1

3.31e-0412472GO:0070561
GeneOntologyBiologicalProcessprimitive hemopoiesis

STK3 LDB1

3.31e-0412472GO:0060215
GeneOntologyBiologicalProcessglycosylation

NPC1 FUT2 MAN2A1 MGAT5B TUSC3

3.63e-04270475GO:0070085
GeneOntologyBiologicalProcessporphyrin-containing compound metabolic process

CYP2A6 HNF1A CYP2A13

4.00e-0463473GO:0006778
GeneOntologyBiologicalProcesssecondary metabolic process

CYP2A6 CYP2A7 CYP2A13

4.80e-0467473GO:0019748
GeneOntologyBiologicalProcessresponse to cadmium ion

NPC1 CYP2A6 CYP2A13

5.01e-0468473GO:0046686
GeneOntologyBiologicalProcessarachidonate metabolic process

CYP2A6 CYP2A7 CYP2A13

5.01e-0468473GO:0019369
GeneOntologyBiologicalProcesspositive regulation of transcription initiation by RNA polymerase II

HNF1A HNF1B MED1

5.45e-0470473GO:0060261
GeneOntologyBiologicalProcesstetrapyrrole metabolic process

CYP2A6 HNF1A CYP2A13

6.17e-0473473GO:0033013
GeneOntologyBiologicalProcesspositive regulation of DNA-templated transcription initiation

HNF1A HNF1B MED1

7.21e-0477473GO:2000144
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP2A6 CYP2A7 CYP2A13 ACOT8

7.47e-04180474GO:0120254
GeneOntologyBiologicalProcessregulation of transcription initiation by RNA polymerase II

HNF1A HNF1B MED1

8.35e-0481473GO:0060260
GeneOntologyBiologicalProcessplacenta development

STK3 NCOA6 HNF1A MED1

1.04e-03197474GO:0001890
GeneOntologyBiologicalProcessbranch elongation of an epithelium

HNF1B MED1

1.14e-0322472GO:0060602
GeneOntologyBiologicalProcessresponse to xenobiotic stimulus

NPC1 CYP2A6 CYP2A7 CYP2A13 BCAR3 PLIN2

1.17e-03525476GO:0009410
GeneOntologyBiologicalProcessregulation of DNA-templated transcription initiation

HNF1A HNF1B MED1

1.17e-0391473GO:2000142
GeneOntologyBiologicalProcessmuscle tissue morphogenesis

COL11A1 PAX7 MED1

1.25e-0393473GO:0060415
GeneOntologyBiologicalProcesscellular response to vitamin D

MED1 MN1

1.25e-0323472GO:0071305
GeneOntologyBiologicalProcesspigment metabolic process

CYP2A6 HNF1A CYP2A13

1.29e-0394473GO:0042440
GeneOntologyBiologicalProcessnegative regulation of neuron differentiation

ZNF536 MED1 CIT

1.29e-0394473GO:0045665
GeneOntologyBiologicalProcesscarbohydrate derivative biosynthetic process

NPC1 HNF1A ACOT8 FUT2 MAN2A1 MGAT5B TUSC3

1.30e-03736477GO:1901137
GeneOntologyBiologicalProcesstissue morphogenesis

STK3 HNF1A HNF1B COL11A1 PAX7 MED1 CECR2

1.45e-03750477GO:0048729
GeneOntologyBiologicalProcesslactate metabolic process

LDHAL6B LDHAL6A

1.47e-0325472GO:0006089
GeneOntologyBiologicalProcessnegative regulation of developmental process

STK3 ANKRD17 HNF1B ZNF536 BICRAL LDB1 MED1 TRIO CIT

1.53e-031220479GO:0051093
GeneOntologyBiologicalProcessgland development

NPC1 HOXB3 HNF1A HNF1B MAN2A1 MED1

1.60e-03558476GO:0048732
GeneOntologyBiologicalProcesssteroid metabolic process

NPC1 CYP2A6 HNF1A ACOT8 MED1

1.60e-03376475GO:0008202
GeneOntologyBiologicalProcessregulation of TORC1 signaling

NPC1 USP6 USP32

1.63e-03102473GO:1903432
GeneOntologyBiologicalProcessmuscle organ morphogenesis

COL11A1 PAX7 MED1

1.63e-03102473GO:0048644
GeneOntologyBiologicalProcessDNA-templated transcription initiation

NCOA6 HNF1A HNF1B MED1

1.87e-03231474GO:0006352
GeneOntologyBiologicalProcessTORC1 signaling

NPC1 USP6 USP32

1.97e-03109473GO:0038202
GeneOntologyBiologicalProcessanimal organ morphogenesis

HOXB3 HNF1A HNF1B COL11A1 PAX7 BCAR3 MAN2A1 MED1 DNAH11

2.00e-031269479GO:0009887
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

NPC1 LDHAL6B CYP2A6 CYP2A7 HNF1A CYP2A13 ACOT8 LDHAL6A

2.15e-031035478GO:0019752
GeneOntologyBiologicalProcessin utero embryonic development

STK3 NCOA6 HNF1A HNF1B MAN2A1 MED1

2.23e-03596476GO:0001701
GeneOntologyBiologicalProcesscellular response to vitamin

MED1 MN1

2.27e-0331472GO:0071295
GeneOntologyBiologicalProcesspositive regulation of intracellular signal transduction

AKAP6 STK3 ANKRD17 USP6 HNF1A BCAR3 MED1 MN1 USP32

2.35e-031299479GO:1902533
GeneOntologyBiologicalProcessnegative regulation of transcription by RNA polymerase II

HOXB3 HNF1A HNF1B ZNF536 MLIP LDB1 MED1 NCOA5

2.39e-031053478GO:0000122
GeneOntologyBiologicalProcessoxoacid metabolic process

NPC1 LDHAL6B CYP2A6 CYP2A7 HNF1A CYP2A13 ACOT8 LDHAL6A

2.47e-031058478GO:0043436
GeneOntologyBiologicalProcessembryonic placenta development

STK3 NCOA6 MED1

2.52e-03119473GO:0001892
GeneOntologyBiologicalProcessorganic acid metabolic process

NPC1 LDHAL6B CYP2A6 CYP2A7 HNF1A CYP2A13 ACOT8 LDHAL6A

2.55e-031064478GO:0006082
MousePhenoabnormal bile salt homeostasis

CYP2A6 CYP2A7 NCOA6 CYP2A13

1.14e-0547424MP:0005365
MousePhenodecreased intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13

1.67e-0517423MP:0002647
MousePhenoabnormal intestinal cholesterol absorption

CYP2A6 CYP2A7 CYP2A13

2.36e-0519423MP:0002645
MousePhenoabnormal intestinal lipid absorption

CYP2A6 CYP2A7 CYP2A13

1.07e-0431423MP:0005342
MousePhenoimpaired placental function

NCOA6 MED1

1.31e-046422MP:0006372
DomainCyt_P450_E_grp-I_CYP2A-like

CYP2A6 CYP2A7 CYP2A13

5.58e-084463IPR008067
DomainHNF1_dimer_dom

HNF1A HNF1B

5.93e-062462IPR023219
DomainHNF1b_C

HNF1A HNF1B

5.93e-062462IPR006897
DomainHNF-1B_C

HNF1A HNF1B

5.93e-062462PF04812
DomainHNF-1_N

HNF1A HNF1B

1.78e-053462IPR006899
DomainHNF-1_N

HNF1A HNF1B

1.78e-053462PF04814
DomainL-lactate_DH

LDHAL6B LDHAL6A

5.91e-055462IPR011304
DomainL-lactate_DH_AS

LDHAL6B LDHAL6A

5.91e-055462IPR018177
DomainL_LDH

LDHAL6B LDHAL6A

5.91e-055462PS00064
DomainLdh_1_N

LDHAL6B LDHAL6A

1.65e-048462PF00056
DomainL-lactate/malate_DH

LDHAL6B LDHAL6A

1.65e-048462IPR001557
DomainLactate/malate_DH_N

LDHAL6B LDHAL6A

1.65e-048462IPR001236
DomainCyt_P450_E_grp-I

CYP2A6 CYP2A7 CYP2A13

1.85e-0445463IPR002401
Domain-

LDHAL6B LDHAL6A

2.11e-0494623.90.110.10
DomainLactate/malate_DH_C

LDHAL6B LDHAL6A

2.11e-049462IPR022383
DomainLactate_DH/Glyco_Ohase_4_C

LDHAL6B LDHAL6A

2.11e-049462IPR015955
DomainLdh_1_C

LDHAL6B LDHAL6A

2.11e-049462PF02866
DomainCyt_P450_CS

CYP2A6 CYP2A7 CYP2A13

3.00e-0453463IPR017972
DomainCYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13

3.73e-0457463PS00086
Domain-

CYP2A6 CYP2A7 CYP2A13

3.92e-04584631.10.630.10
Domainp450

CYP2A6 CYP2A7 CYP2A13

3.92e-0458463PF00067
DomainCyt_P450

CYP2A6 CYP2A7 CYP2A13

4.34e-0460463IPR001128
Domain-

HNF1A HNF1B

2.00e-03274621.10.260.40
DomainLambda_DNA-bd_dom

HNF1A HNF1B

2.31e-0329462IPR010982
DomainHomeobox

HOXB3 HNF1A HNF1B PAX7

2.59e-03234464PF00046
DomainHOMEOBOX_1

HOXB3 HNF1A HNF1B PAX7

2.68e-03236464PS00027
DomainHOX

HOXB3 HNF1A HNF1B PAX7

2.72e-03237464SM00389
DomainHomeobox_dom

HOXB3 HNF1A HNF1B PAX7

2.80e-03239464IPR001356
DomainHOMEOBOX_2

HOXB3 HNF1A HNF1B PAX7

2.80e-03239464PS50071
DomainSpectrin/alpha-actinin

AKAP6 TRIO

2.81e-0332462IPR018159
DomainSPEC

AKAP6 TRIO

2.81e-0332462SM00150
DomainKH_1

ANKRD17 ANKHD1

3.94e-0338462PF00013
DomainKH

ANKRD17 ANKHD1

4.36e-0340462SM00322
DomainKH_dom

ANKRD17 ANKHD1

4.36e-0340462IPR004087
DomainKH_TYPE_1

ANKRD17 ANKHD1

4.80e-0342462PS50084
Domain-

HOXB3 HNF1A HNF1B PAX7

5.11e-032834641.10.10.60
DomainKH_dom_type_1

ANKRD17 ANKHD1

5.26e-0344462IPR004088
DomainTBC

USP6 SGSM2

6.48e-0349462SM00164
DomainRabGAP-TBC

USP6 SGSM2

7.55e-0353462PF00566
DomainTBC_RABGAP

USP6 SGSM2

8.11e-0355462PS50086
DomainRab-GTPase-TBC_dom

USP6 SGSM2

8.11e-0355462IPR000195
DomainHomeodomain-like

HOXB3 HNF1A HNF1B PAX7

8.90e-03332464IPR009057
DomainUSP_CS

USP6 USP32

1.15e-0266462IPR018200
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13

2.09e-0611343M27130
PathwayREACTOME_CYP2E1_REACTIONS

CYP2A6 CYP2A7 CYP2A13

2.78e-0612343MM14847
PathwayREACTOME_FATTY_ACIDS

CYP2A6 CYP2A7 CYP2A13

1.02e-0518343MM14841
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13

2.20e-0523343M5372
PathwayREACTOME_XENOBIOTICS

CYP2A6 CYP2A7 CYP2A13

2.84e-0525343MM14846
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_TO_DNA_ADDUCTS

CYP2A6 CYP2A13

5.62e-055342M47808
PathwayKEGG_N_GLYCAN_BIOSYNTHESIS

MAN2A1 MGAT5B TUSC3

1.81e-0446343M11079
PathwayKEGG_DRUG_METABOLISM_OTHER_ENZYMES

CYP2A6 CYP2A7 CYP2A13

2.47e-0451343M17726
PathwayWP_NGLYCAN_BIOSYNTHESIS

MAN2A1 MGAT5B TUSC3

3.43e-0457343M48051
PathwayWP_OXIDATION_BY_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13

4.40e-0462343M39653
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13

4.83e-0464343M5650
PathwayKEGG_RETINOL_METABOLISM

CYP2A6 CYP2A7 CYP2A13

4.83e-0464343M9488
PathwayREACTOME_CYTOCHROME_P450_ARRANGED_BY_SUBSTRATE_TYPE

CYP2A6 CYP2A7 CYP2A13

5.29e-0466343MM14839
PathwayBIOCARTA_PITX2_PATHWAY

LDB1 MED1

5.81e-0415342MM1439
PathwayREACTOME_FATTY_ACIDS

CYP2A7 CYP2A13

5.81e-0415342M27126
PathwayBIOCARTA_PITX2_PATHWAY

LDB1 MED1

6.63e-0416342M8516
PathwayKEGG_DRUG_METABOLISM_CYTOCHROME_P450

CYP2A6 CYP2A7 CYP2A13

6.82e-0472343M9257
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

NCOA6 MED1

8.43e-0418342M26942
PathwayREACTOME_MITOCHONDRIAL_BIOGENESIS

NCOA6 MED1 APOOL

1.57e-0396343M26973
PathwayKEGG_MATURITY_ONSET_DIABETES_OF_THE_YOUNG

HNF1A HNF1B

1.64e-0325342M18312
PathwayKEGG_MEDICUS_REFERENCE_GLYCOLYSIS

LDHAL6B LDHAL6A

1.64e-0325342M47623
PathwayREACTOME_AFLATOXIN_ACTIVATION_AND_DETOXIFICATION

CYP2A6 CYP2A13

1.77e-0326342MM15190
PathwayWP_7OXOC_AND_7BETAHC_PATHWAYS

NPC1 ACOT8

1.91e-0327342M40054
PathwayREACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION

NCOA6 MED1

1.91e-0327342M26943
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13

1.98e-03104343M738
PathwayREACTOME_PHASE_I_FUNCTIONALIZATION_OF_COMPOUNDS

CYP2A6 CYP2A7 CYP2A13

2.03e-03105343MM14842
PathwayWP_CONSTITUTIVE_ANDROSTANE_RECEPTOR_PATHWAY

CYP2A6 NCOA6

2.51e-0331342M39476
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

NCOA6 MED1 PLIN2

2.83e-03118343M27316
PathwayKEGG_PROPANOATE_METABOLISM

LDHAL6B LDHAL6A

2.84e-0333342M4086
PathwayKEGG_CYSTEINE_AND_METHIONINE_METABOLISM

LDHAL6B LDHAL6A

3.02e-0334342M10911
PathwayREACTOME_MATURATION_OF_SPIKE_PROTEIN

MAN2A1 TUSC3

3.57e-0337342M41728
Pubmed

Cerium-induced strain-dependent increase in Cyp2a-4/5 (cytochrome P4502a-4/5) expression in the liver and kidneys of inbred mice.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934831417950
Pubmed

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

CYP2A6 CYP2A7 CYP2A13

2.47e-09348331645370
Pubmed

Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.

CYP2A6 CYP2A7 CYP2A13

2.47e-09348324045421
Pubmed

Highly homologous mouse Cyp2a4 and Cyp2a5 genes are differentially expressed in the liver and both express long non-coding antisense RNAs.

CYP2A6 CYP2A7 CYP2A13

2.47e-09348332987105
Pubmed

Reciprocal regulation of sex-dependent expression of testosterone 15 alpha-hydroxylase (P-450(15 alpha)) in liver and kidney of male mice by androgen. Evidence for a single gene.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934833346244
Pubmed

Alteration of the substrate specificity of mouse 2A P450s by the identity of residue-209: steroid-binding site and orientation.

CYP2A6 CYP2A7 CYP2A13

2.47e-09348322217847
Pubmed

Mouse steroid 15 alpha-hydroxylase gene family: identification of type II P-450(15)alpha as coumarin 7-hydroxylase.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934832765478
Pubmed

Sexual dimorphism of testosterone 15 alpha-hydroxylase mRNA levels in mouse liver. cDNA cloning and regulation.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934832415518
Pubmed

Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934832733794
Pubmed

A trans-acting locus regulates transcriptional repression of the female-specific steroid 15 alpha-hydroxylase gene in male mice.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934838297477
Pubmed

Differential distribution of CYP2A6 and CYP2A13 in the human respiratory tract.

CYP2A6 CYP2A7 CYP2A13

2.47e-09348322890016
Pubmed

Lack of the steroid 15 alpha-hydroxylase gene (Cyp2a-4) in wild mouse strain Mus spretus: rapid evolution of the P450 gene superfamily.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934838188299
Pubmed

Site-directed mutagenesis of mouse steroid 7 alpha-hydroxylase (cytochrome P-450(7) alpha): role of residue-209 in determining steroid-cytochrome P-450 interaction.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934838484736
Pubmed

Comparison of hamster and mouse reveals interspecies differences in the regulation of hepatic CYP2A isozymes.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934838250953
Pubmed

The structure and characterization of type I P-450(15) alpha gene as major steroid 15 alpha-hydroxylase and its comparison with type II P-450(15) alpha gene.

CYP2A6 CYP2A7 CYP2A13

2.47e-0934832703500
Pubmed

Transcriptional regulation by HNF-4 of the steroid 15alpha-hydroxylase P450 (Cyp2a-4) gene in mouse liver.

CYP2A6 CYP2A7 CYP2A13

9.86e-0944839408084
Pubmed

A DNA methylation site in the male-specific P450 (Cyp 2d-9) promoter and binding of the heteromeric transcription factor GABP.

CYP2A6 CYP2A7 CYP2A13

9.86e-0944837565685
Pubmed

Circadian expression of the steroid 15 alpha-hydroxylase (Cyp2a4) and coumarin 7-hydroxylase (Cyp2a5) genes in mouse liver is regulated by the PAR leucine zipper transcription factor DBP.

CYP2A6 CYP2A7 CYP2A13

9.86e-09448310490589
Pubmed

Two steroid 15 alpha-hydroxylase genes and a homologous gene family in mice.

CYP2A6 CYP2A7 CYP2A13

9.86e-0944831970547
Pubmed

A genetic polymorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles.

CYP2A6 CYP2A7 CYP2A13

4.92e-0864837668294
Pubmed

Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19.

CYP2A6 CYP2A7 CYP2A13

4.92e-0864838587134
Pubmed

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses.

CYP2A6 CYP2A7 CYP2A13

8.60e-0874839630227
Pubmed

Organization and evolution of the Cyp2 gene cluster on mouse chromosome 7, and comparison with the syntenic human cluster.

CYP2A6 CYP2A7 CYP2A13

8.60e-08748314630516
Pubmed

Maternal DHA intake in mice increased DHA metabolites in the pup brain and ameliorated MeHg-induced behavioral disorder.

CYP2A6 CYP2A7 CYP2A13

2.06e-07948337838304
Pubmed

Establishment and analysis of a mouse model that regulates sex-related differences in liver drug metabolism.

CYP2A6 CYP2A7 CYP2A13

1.11e-061548329968852
Pubmed

Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver.

CYP2A6 CYP2A7 CYP2A13

1.65e-061748327197076
Pubmed

Expression of CYP2A genes in human liver and extrahepatic tissues.

CYP2A7 CYP2A13

1.87e-06248210353262
Pubmed

Expression and alternative splicing of the cytochrome P-450 CYP2A7.

CYP2A6 CYP2A7

1.87e-0624827864805
Pubmed

Mutations and intronic variants in the HNF-1 beta gene in a group of German and Czech Caucasians with type 2 diabetes mellitus and progressive diabetic nephropathy.

HNF1A HNF1B

1.87e-06248212012276
Pubmed

Interstrain differences in the expression and activity of Cyp2a5 in the mouse liver.

CYP2A6 CYP2A13

1.87e-06248228298240
Pubmed

Genetic polymorphisms for a phenobarbital-inducible cytochrome P-450 map to the Coh locus in mice.

CYP2A6 CYP2A13

1.87e-0624826309775
Pubmed

More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing.

HNF1A HNF1B

1.87e-0624827900999
Pubmed

Characterization of a novel CYP2A7/CYP2A6 hybrid allele (CYP2A6*12) that causes reduced CYP2A6 activity.

CYP2A6 CYP2A7

1.87e-06248212325023
Pubmed

Prognostic relevance of molecular subtypes and master regulators in pancreatic ductal adenocarcinoma.

HNF1A HNF1B

1.87e-06248227520560
Pubmed

Mutations in hepatocyte nuclear factor-1beta and their related phenotypes.

HNF1A HNF1B

1.87e-06248215930087
Pubmed

Two members of an HNF1 homeoprotein family are expressed in human liver.

HNF1A HNF1B

1.87e-0624821677179
Pubmed

Mechanism-based inhibition of cytochrome P450 (CYP)2A6 by chalepensin in recombinant systems, in human liver microsomes and in mice in vivo.

CYP2A6 CYP2A13

1.87e-06248221418183
Pubmed

Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations.

HNF1A HNF1B

1.87e-06248215111528
Pubmed

A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1beta.

HNF1A HNF1B

1.87e-06248210484768
Pubmed

Evaluation of inhibition selectivity for human cytochrome P450 2A enzymes.

CYP2A6 CYP2A13

1.87e-06248222696418
Pubmed

Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.

CYP2A6 CYP2A13

1.87e-06248222262919
Pubmed

USP32 is an active, membrane-bound ubiquitin protease overexpressed in breast cancers.

USP6 USP32

1.87e-06248220549504
Pubmed

Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice.

CYP2A6 CYP2A13

1.87e-06248230876690
Pubmed

Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigrees.

HNF1A HNF1B

1.87e-06248215660195
Pubmed

Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations.

HNF1A HNF1B

1.87e-06248216443774
Pubmed

CYP2A5 induction and hepatocellular stress: an adaptive response to perturbations of heme homeostasis.

CYP2A6 CYP2A13

1.87e-06248221395539
Pubmed

Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.

CYP2A6 CYP2A13

1.87e-06248225635819
Pubmed

Species differences in coumarin metabolism: a molecular modelling evaluation of CYP2A interactions.

CYP2A6 CYP2A13

1.87e-06248212162851
Pubmed

Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.

CYP2A6 CYP2A13

1.87e-0624821302041
Pubmed

Structural alteration of mouse P450coh by mutation of glycine-207 to proline: spin equilibrium, enzyme kinetics, and heat sensitivity.

CYP2A6 CYP2A13

1.87e-0624828395817
Pubmed

Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation.

HNF1A HNF1B

1.87e-06248222160269
Pubmed

Selective deletion of the Hnf1beta (MODY5) gene in beta-cells leads to altered gene expression and defective insulin release.

HNF1A HNF1B

1.87e-06248215142986
Pubmed

Expression of hepatocyte nuclear factor-1alpha mRNA in human anaplastic thyroid cancer cell lines and tumors.

HNF1A HNF1B

1.87e-06248218399756
Pubmed

Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice.

CYP2A6 CYP2A13

1.87e-06248225804444
Pubmed

Genetic variation between mice in their metabolism of coumarin and its derivatives.

CYP2A6 CYP2A13

1.87e-062482566237
Pubmed

Effect of pyrazole, cobalt and phenobarbital on mouse liver cytochrome P-450 2a-4/5 (Cyp2a-4/5) expression.

CYP2A6 CYP2A13

1.87e-0624821520280
Pubmed

Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.

CYP2A6 CYP2A13

1.87e-06248219923441
Pubmed

Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.

CYP2A6 CYP2A13

1.87e-06248223917075
Pubmed

Effects of lipopolysaccharide-stimulated inflammation and pyrazole-mediated hepatocellular injury on mouse hepatic Cyp2a5 expression.

CYP2A6 CYP2A13

1.87e-06248212499123
Pubmed

HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro.

HNF1A HNF1B

1.87e-0624822044952
Pubmed

Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5.

CYP2A6 CYP2A13

1.87e-06248230222954
Pubmed

CYP2A7 polymorphic alleles confound the genotyping of CYP2A6*4A allele.

CYP2A6 CYP2A7

1.87e-06248216636685
Pubmed

Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line.

HNF1A HNF1B

1.87e-06248216297991
Pubmed

Identification and characterization of a 44 kDa protein that binds specifically to the 3'-untranslated region of CYP2a5 mRNA: inducibility, subcellular distribution and possible role in mRNA stabilization.

CYP2A6 CYP2A13

1.87e-0624828611142
Pubmed

Up-regulation of CYP2A5 expression by porphyrinogenic agents in mouse liver.

CYP2A6 CYP2A13

1.87e-0624827543189
Pubmed

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype.

CYP2A6 CYP2A13

1.87e-06248227902773
Pubmed

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

CYP2A6 CYP2A13

1.87e-06248222497566
Pubmed

Characterization and regulation of sex-specific mouse steroid hydroxylase genes.

CYP2A6 CYP2A13

1.87e-0624822372744
Pubmed

Regulation of tissue-specific expression of the human and mouse urate transporter 1 gene by hepatocyte nuclear factor 1 alpha/beta and DNA methylation.

HNF1A HNF1B

1.87e-06248217855651
Pubmed

Coumarin toxicity in different strains of mice.

CYP2A6 CYP2A13

1.87e-062482665441
Pubmed

The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes.

CYP2A6 CYP2A7

1.87e-0624822322567
Pubmed

Genetic variants of hepatocyte nuclear factor-1beta in Chinese young-onset diabetic patients with nephropathy.

HNF1A HNF1B

1.87e-06248214583183
Pubmed

Metabolic effects of CYP2A6 and CYP2A13 on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced gene mutation--a mammalian cell-based mutagenesis approach.

CYP2A6 CYP2A13

1.87e-06248221473878
Pubmed

Differential regulation of serum microRNA expression by HNF1β and HNF1α transcription factors.

HNF1A HNF1B

1.87e-06248227059371
Pubmed

Peroxisome proliferator-activated receptor (PPAR)-binding protein (PBP) but not PPAR-interacting protein (PRIP) is required for nuclear translocation of constitutive androstane receptor in mouse liver.

NCOA6 MED1

1.87e-06248216828057
Pubmed

Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.

CYP2A6 CYP2A13

1.87e-06248224104196
Pubmed

Mutations in the hepatocyte nuclear factor-1β (HNF1B) gene are common with combined uterine and renal malformations but are not found with isolated uterine malformations.

HNF1A HNF1B

1.87e-06248220633866
Pubmed

The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis.

CYP2A6 CYP2A13

1.87e-0624827581481
Pubmed

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

CYP2A6 CYP2A13

1.87e-06248226363552
Pubmed

Circadian Regulation of Hepatic Cytochrome P450 2a5 by Peroxisome Proliferator-Activated Receptor γ.

CYP2A6 CYP2A13

1.87e-06248230154104
Pubmed

Mouse liver P450Coh: genetic regulation of the pyrazole-inducible enzyme and comparison with other P450 isoenzymes.

CYP2A6 CYP2A13

1.87e-0624822712571
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

SUGP1 ANKRD17 USP6 NCOA6 ZNF536 ACOT8 MED1 DNAH11

2.43e-0663848831182584
Pubmed

Molecular genetics of the human cytochrome P450 monooxygenase superfamily.

CYP2A6 CYP2A7 CYP2A13

2.77e-06204839890157
Pubmed

Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes.

CYP2A6 CYP2A13

5.59e-06348218602936
Pubmed

Mst1/2 Is Necessary for Satellite Cell Differentiation to Promote Muscle Regeneration.

STK3 PAX7

5.59e-06348235511870
Pubmed

Expression of cytochrome P450 2A5 in a glucose-6-phosphate dehydrogenase-deficient mouse model of oxidative stress.

CYP2A6 CYP2A13

5.59e-06348218068688
Pubmed

Identification of a novel human lactate dehydrogenase gene LDHAL6A, which activates transcriptional activities of AP1(PMA).

LDHAL6B LDHAL6A

5.59e-06348218351441
Pubmed

Regulation of the expression of human organic anion transporter 3 by hepatocyte nuclear factor 1alpha/beta and DNA methylation.

HNF1A HNF1B

5.59e-06348216793932
Pubmed

Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes.

HNF1A HNF1B

5.59e-06348219924231
Pubmed

Variants in MODY genes associated with maternal lipids profiles in second trimester of pregnancy.

HNF1A HNF1B

5.59e-06348228591938
Pubmed

CYP2A6/2A7 and CYP2E1 expression in human oesophageal mucosa: regional and inter-individual variation in expression and relevance to nitrosamine metabolism.

CYP2A6 CYP2A7

5.59e-06348211960914
Pubmed

Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.

CYP2A6 CYP2A13

5.59e-0634823219345
Pubmed

Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth.

HNF1A HNF1B

5.59e-06348217923767
Pubmed

Close linkage of the cytochrome P450IIA gene subfamily (Cyp2a) to Cyp2b and Coh on mouse chromosome 7.

CYP2A6 CYP2A13

5.59e-0634821973143
Pubmed

Zfp30, a KRAB domain containing zinc finger protein gene, maps to mouse chromosome 7.

CYP2A6 CYP2A13

5.59e-0634827849402
Pubmed

The mouse alpha-albumin (afamin) promoter is differentially regulated by hepatocyte nuclear factor 1α and hepatocyte nuclear factor 1β.

HNF1A HNF1B

5.59e-06348220979532
Pubmed

A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.

CYP2A6 CYP2A13

5.59e-06348221252290
Pubmed

Mitochondrial targeting of bilirubin regulatory enzymes: An adaptive response to oxidative stress.

CYP2A6 CYP2A13

5.59e-06348225478736
Pubmed

Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.

CYP2A6 CYP2A13

5.59e-06348220840855
Pubmed

Maturity onset diabetes of youth (MODY) in Turkish children: sequence analysis of 11 causative genes by next generation sequencing.

HNF1A HNF1B

5.59e-06348226669242
InteractionCYP2A7 interactions

CYP2A6 CYP2A7 CYP2A13

1.11e-083463int:CYP2A7
Cytoband19q13.2

CYP2A6 CYP2A7 CYP2A13

6.88e-0416448319q13.2
CytobandXq25

TEX13C TEX13D

8.55e-0441482Xq25
CytobandEnsembl 112 genes in cytogenetic band chrXq25

TEX13C TEX13D

1.17e-0348482chrXq25
Cytoband17q12

HNF1B MED1

4.87e-039948217q12
GeneFamilyHNF class homeoboxes

HNF1A HNF1B

7.45e-063292524
GeneFamilyCytochrome P450 family 2

CYP2A6 CYP2A7 CYP2A13

2.35e-05352931001
GeneFamilyUbiquitin specific peptidases

USP6 USP32

3.63e-0356292366
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

STK3 ANKRD17 USP6 BICRAL BCAR3 MAN2A1 MED1 TRIO MN1

1.51e-05856469M4500
CoexpressionWENG_POR_DOSAGE

CYP2A6 CYP2A7 CYP2A13

1.99e-0530463MM1199
CoexpressionGSE19825_NAIVE_VS_IL2RAHIGH_DAY3_EFF_CD8_TCELL_UP

AKAP6 TMEM266 HOXB3 ZNF536 TRIO

2.62e-05200465M4299
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AKAP6 ZNF536 PAX7 MLIP BCAR3

1.79e-06188485794fc1d9a726945c42f7eac221eed938309b47a9
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A13 PAX7 FUT2 DNAH11

1.88e-061904852fdc024d3d673a0134b74b4c5a63afe924995730
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Ductal_and_Mucinous_Carcinoma-1|TCGA-Breast / Sample_Type by Project: Shred V9

CYP2A6 CYP2A7 CYP2A13 UNC80

1.80e-051454841e52e3c615b49e7388cd58a04e74cafac9552447
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMEM266 ZNF536 MLIP UNC80

2.92e-051644843caf4cdaa0164907893fea61e251fd8b5fa926e4
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A7 CYP2A13 FUT2

3.68e-0517448442f2ba54b4ea4c62482582b0ccdadffae0a5eb4a
ToppCellP15-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ZNF536 COL11A1 MLIP SGSM2

3.85e-05176484792f414f5092aba14260b8e16378e793a822498e
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-unknown|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HNF1B ZNF536 MLIP UNC80

4.77e-05186484ea936e66ae4b7b40564711fad60ac0137327995f
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HNF1B ZNF536 MLIP UNC80

4.87e-05187484a0bd2b0ec9e73521c245037b1dd51ff8cf24cbf5
ToppCelldroplet-Limb_Muscle-nan-24m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HNF1B ZNF536 MLIP UNC80

4.87e-05187484f2af79a20438108c814a73f9e24cd986d537237f
ToppCellTCGA-Colorectal-Primary_Tumor-Colorectal_Adenocarcinoma-Colon_Adenocarcinoma-7|TCGA-Colorectal / Sample_Type by Project: Shred V9

NCOA6 COL11A1 TRIO NCOA5

4.98e-0518848414bc73cf79c79c9f208369fd8d498e5b26e0114d
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

AKAP6 MLIP CECR2 PLIN2

5.18e-051904843729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellMyeloid-Myeloid-B_(Activated_Macrophage)|Myeloid / shred on cell class and cell subclass (v4)

NPC1 BCAR3 MAN2A1 PLIN2

5.29e-051914847bf125249af1e8bb138ed4d999fdd74b03ab2447
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

STK3 ANKRD17 TRIO DENND1A

5.40e-05192484e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellnucseq|World / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ANKRD17 ANKHD1 TRIO DENND1A

5.51e-05193484779276e775cb2492e8dd36436295a536084a6415
ToppCellParenchymal-NucSeq-Stromal-Fibroblastic-Fibro_perichondrial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

HOXB3 COL11A1 EGR3 MGAT5B

5.51e-05193484e5016959f24370579a8770787e96869f264cf7b3
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A6 CYP2A7 CYP2A13 FUT2

5.51e-05193484605fc2a25ed6846fb283b2918cfed98df6039d6b
ToppCellTCGA-Prostate-Primary_Tumor-Prostate_Adenocarcinoma-Acinar_Adenocarcinoma-6|TCGA-Prostate / Sample_Type by Project: Shred V9

MAN2A1 MED1 APOOL USP32

5.51e-05193484abd71b2cf667ef2b1c4d88acd0c1dd19a12ff659
ToppCell3'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(nasal)-Club_(nasal)_L.0.2.1.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CYP2A7 CYP2A13 PAX7 FUT2

6.08e-05198484e3d1c9428ee6f9bcf9cdaf2192d4ebea8cc2a47c
ToppCelldistal-1-Epithelial-Club|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP2A6 CYP2A7 CYP2A13 CIT

6.20e-051994848f0a72a95d0310ef2324c6975495c294b5a47cc8
ToppCellParenchyma_Control_(B.)-Epithelial-TX-Club|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type

CYP2A6 CYP2A7 CYP2A13 FUT2

6.20e-05199484111cfd589ec6795075d8d88d7664bfb23eba5bf6
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CYP2A6 CYP2A7 CYP2A13 FUT2

6.20e-05199484d583290a1d288b749ad17bc501c1487268c6551c
ToppCellLung_Parenchyma-Control-Epithelial-Epithelial-Club|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

CYP2A6 CYP2A7 CYP2A13 FUT2

6.20e-051994842b17694cffbec28a2c8f165dfcff6bab94aa0f4c
ToppCelldistal-Epithelial-Club-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

CYP2A6 CYP2A7 CYP2A13 CIT

6.20e-05199484685cefbe6ff5db8b578e50b5849524ac2f347d0c
ToppCellNeuronal-Excitatory-eC(RORB)|Neuronal / cells hierarchy compared to all cells using T-Statistic

COL11A1 MLIP BCAR3 MGAT5B

6.33e-052004848c803a0ce25e140b46036f6aabefc5502601f408
Drug2'-methoxyacetophenone

CYP2A6 CYP2A7 CYP2A13

8.24e-093473CID000068481
Drugdiosmetin

CYP2A6 CYP2A7 HNF1B CYP2A13 MED1

8.73e-0785475CID005281612
Drugbromobenzene

LDHAL6B CYP2A6 CYP2A7 CYP2A13 LDHAL6A

1.68e-0697475CID000007961
DrugN-nitrosomethylaniline

CYP2A6 CYP2A7 CYP2A13

2.95e-0614473CID000011957
Drugproadifen hydrochloride

LDHAL6B CYP2A6 CYP2A7 CYP2A13 LDHAL6A

3.74e-06114475CID000004910
Drugnicotine imine

CYP2A6 CYP2A13

4.17e-062472ctd:C034629
Drugpropargyl ether

CYP2A6 CYP2A13

4.17e-062472ctd:C531209
Drugalpha-nicotyrine

CYP2A6 CYP2A13

4.17e-062472ctd:C008615
DrugHempa

CYP2A6 CYP2A13

4.17e-062472ctd:D006492
DrugN-nitrosoguvacoline

CYP2A6 CYP2A13

4.17e-062472ctd:C036676
Drugpotassium citrate

LDHAL6B LDHAL6A CIT

4.53e-0616473CID000013344
Drughydride

LDHAL6B CYP2A6 CYP2A7 NCOA6 CYP2A13 ACOT8 PAX7 MAN2A1 LDHAL6A MED1

6.30e-068354710CID000000783
DrugN-(3,5-dichlorophenyl)-2-hydroxysuccinimide

LDHAL6B NCOA6 LDHAL6A

6.58e-0618473CID000114902
DrugNAPQI

LDHAL6B CYP2A6 NCOA6 LDHAL6A

7.63e-0661474CID000039763
Drugchlorzoxazone

CYP2A6 CYP2A7 HNF1A CYP2A13

8.68e-0663474CID000002733
Drug2-ethylhexanol

LDHAL6B CYP2A6 LDHAL6A

1.24e-0522473CID000007720
DrugNSC35549

CYP2A6 CYP2A7 CYP2A13

1.24e-0522473CID000411697
Drug4-bromophenol

CYP2A6 CYP2A7 NCOA6 CYP2A13

1.32e-0570474CID000007808
Drugbromide

LDHAL6B CYP2A6 CYP2A7 CYP2A13 LDHAL6A MGAT5B

1.76e-05267476CID000000259
DrugC14845

CYP2A6 CYP2A7 CYP2A13

2.33e-0527473CID011954064
DrugBP-9,10-oxide

CYP2A6 CYP2A7 CYP2A13

2.33e-0527473CID000037456
DrugBrn 4136738

CYP2A6 CYP2A7 CYP2A13

2.33e-0527473CID000050331
DrugNMPA

CYP2A6 CYP2A13

2.50e-054472CID000132101
DrugN'-nitrosoanatabine

CYP2A6 CYP2A13

2.50e-054472ctd:C032978
Drug9-OH-BaP-4,5-oxide

CYP2A6 CYP2A7 CYP2A13

2.60e-0528473CID000115064
DrugN-nitrosodibutylamine

CYP2A6 ACOT8 FUT2

2.60e-0528473CID000013542
Drugandrost-16-en-3-one

CYP2A6 HNF1A HNF1B

2.60e-0528473CID000086705
Drugdifluorophosphine

SUGP1 HNF1A HNF1B

2.90e-0529473CID000139636
Drug11-H-14,15-EETA

CYP2A6 CYP2A7 CYP2A13

3.22e-0530473CID011954058
Drug19-hydroxytestosterone

CYP2A6 CYP2A7 CYP2A13

3.22e-0530473CID000150968
Drugmephenytoin

CYP2A6 CYP2A7 CYP2A13 CIT

3.27e-0588474CID000004060
Drugrifampicin

USP6 CYP2A6 CYP2A7 HNF1A HNF1B CYP2A13

3.79e-05306476CID005381226
DrugBP-7,8-oxide

CYP2A6 CYP2A7 CYP2A13

3.92e-0532473CID000037455
Drugspirobishexahydropyrimidine

LDHAL6B LDHAL6A

4.15e-055472CID000100750
DrugAC1O5TJF

LDHAL6B LDHAL6A

4.15e-055472CID006440410
Drug1,4-diethoxybutane

LDHAL6B LDHAL6A

4.15e-055472CID000232578
DrugS-lac-NAD

LDHAL6B LDHAL6A

4.15e-055472CID000194292
Drugsorbarin

LDHAL6B LDHAL6A

4.15e-055472CID009824100
Drugacetylphosphonic acid

LDHAL6B LDHAL6A

4.15e-055472CID000081311
DrugNSC-60195

LDHAL6B LDHAL6A

4.15e-055472CID000020481
Drugethyl gossypol

LDHAL6B LDHAL6A

4.15e-055472CID000374353
DrugAC1O5ZB9

LDHAL6B LDHAL6A

4.15e-055472CID006443605
DrugAC1L49DG

LDHAL6B LDHAL6A

4.15e-055472CID000152931
DrugN-methyl-N-2-(methylsulfinyl)ethylpropionic acid amide

CYP2A6 CYP2A13

4.15e-055472ctd:C062567
Drugbenzyl selenocyanate

CYP2A6 CYP2A13

4.15e-055472ctd:C054108
Drugoxyayanin A

LDHAL6B LDHAL6A

4.15e-055472CID005281676
DrugB-HAD

LDHAL6B LDHAL6A

4.15e-055472CID000131338
DrugSQ 31,486

LDHAL6B LDHAL6A

4.15e-055472CID000130015
DrugN-trifluoroacetyl-glycine

LDHAL6B LDHAL6A

4.15e-055472CID000136227
DrugBMS-188107

LDHAL6B LDHAL6A

4.15e-055472CID000192297
Drugchrysotile

LDHAL6B ACOT8 LDHAL6A

4.31e-0533473CID000025477
DrugAC1Q6L57

LDHAL6B LDHAL6A CIT

4.72e-0534473CID000090740
Drug12(13)-EpOME

CYP2A6 CYP2A7 CYP2A13

4.72e-0534473CID000001416
DrugTCEO

CYP2A6 CYP2A7 CYP2A13

4.72e-0534473CID000028167
DrugAC1O5XSP

CYP2A6 CYP2A7 CYP2A13

4.72e-0534473CID006442739
DrugAC1L1CJI

CYP2A6 CYP2A7 CYP2A13

5.15e-0535473CID000001929
Drugtolbutamide

CYP2A6 CYP2A7 HNF1A HNF1B CYP2A13

5.39e-05198475CID000005505
DrugMerbromin [129-16-8]; Down 200; 5uM; PC3; HT_HG-U133A

SUGP1 HNF1B TRIO SGSM2 TUSC3

5.52e-051994757398_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; MCF7; HT_HG-U133A

SUGP1 STK3 BICRAL TRIO TUSC3

5.52e-051994756969_DN
Drug15-H-11,12-EETA

CYP2A6 CYP2A7 CYP2A13

5.61e-0536473CID011954042
DrugAC1L3NGJ

CYP2A6 CYP2A7 CYP2A13

5.61e-0536473CID000092121
Drughexamethylphosphoramide

CYP2A6 CYP2A7 CYP2A13

5.61e-0536473CID000012679
Drugbeta-naphthoflavone

LDHAL6B CYP2A6 CYP2A7 CYP2A13 LDHAL6A

5.65e-05200475CID000002361
Drugacenaphthene-1-ol

CYP2A6 CYP2A13

6.22e-056472ctd:C023723
DrugAC1L24G8

LDHAL6B LDHAL6A

6.22e-056472CID000066023
DrugBL-443

LDHAL6B LDHAL6A

6.22e-056472CID000054436
Drugoxymethacil

LDHAL6B LDHAL6A

6.22e-056472CID000096369
Drugdansyl-L-lysine

LDHAL6B LDHAL6A

6.22e-056472CID000598797
DrugI 65

LDHAL6B LDHAL6A

6.22e-056472CID000149068
DrugD 701

LDHAL6B LDHAL6A

6.22e-056472CID003051460
Drug2,3-dihydroxy-1-naphthoic acid

LDHAL6B LDHAL6A

6.22e-056472CID000028002
DrugAC1L196J

CYP2A6 CYP2A13

6.22e-056472CID000000415
Drugmenthofuran

CYP2A6 CYP2A13

6.22e-056472ctd:C054487
DrugSQ 32,926

LDHAL6B LDHAL6A

6.22e-056472CID000131363
DrugN'-nitrosoanabasine

CYP2A6 CYP2A13

6.22e-056472ctd:C010257
Drugdiphenyl diselenide

LDHAL6B FUT2 LDHAL6A

6.61e-0538473CID000015460
Drug11,14,15-THET

CYP2A6 CYP2A7 CYP2A13

7.15e-0539473CID006439531
DrugGDCA

LDHAL6B HNF1B LDHAL6A

8.32e-0541473CID000003493
DrugN-acetyl-9-O-lactylneuraminic acid

LDHAL6B LDHAL6A

8.70e-057472CID000191486
Drugdidesmethylcitalopram

EGR3 CIT

8.70e-057472CID000162976
Drugsodium glycolate

LDHAL6B LDHAL6A

8.70e-057472CID000517347
DrugAC1O7170

LDHAL6B LDHAL6A

8.70e-057472CID006540699
DrugAC1NSM0G

LDHAL6B LDHAL6A

8.70e-057472CID005365671
DrugBS35

LDHAL6B LDHAL6A

8.70e-057472CID000029316
DrugBS36

LDHAL6B LDHAL6A

8.70e-057472CID000029308
Drugpentabromoacetone

LDHAL6B LDHAL6A

8.70e-057472CID000065579
Drugacenaphthene

CYP2A6 CYP2A13

8.70e-057472ctd:C042552
Drugmethyl-4-hydroxy-3-nitrobenzimidate

LDHAL6B LDHAL6A

8.70e-057472CID005492576
Druggossylic iminolactone

LDHAL6B LDHAL6A

8.70e-057472CID005479302
Drug11,12,15-trihydroxyeicosatrienoic acid

CYP2A6 CYP2A7 CYP2A13

8.94e-0542473CID006439610
Drugpolybrominated biphenyl

CYP2A6 CYP2A7 CYP2A13

1.03e-0444473CID000042948
DrugCo-protoporphyrin IX

CYP2A6 CYP2A7 CYP2A13 CIT

1.03e-04118474CID000004972
Drugbenzphetamine

CYP2A6 CYP2A7 CYP2A13 ACOT8

1.06e-04119474CID000002341
Drugnaphthalene-1,2-dihydrodiol

CYP2A6 CYP2A7 CYP2A13

1.10e-0445473CID000000362
Drug3-methylcholanthrene

CYP2A6 CYP2A7 HNF1A HNF1B CYP2A13

1.12e-04231475CID000001674
DrugU75412E

LDHAL6B LDHAL6A

1.16e-048472CID003035460
DrugAC1Q3O0A

LDHAL6B LDHAL6A

1.16e-048472CID000060880
DrugUR-12633

LDHAL6B LDHAL6A

1.16e-048472CID000128030
Drugp-(phenoxypropoxy)aniline

LDHAL6B LDHAL6A

1.16e-048472CID000423258
Drug2-methyl-2-pentenoate

LDHAL6B LDHAL6A

1.16e-048472CID000018458
DiseaseC-reactive protein measurement

NPC1 AKAP6 CYP2A6 CYP2A7 NCOA6 HNF1A HNF1B ZNF536 FUT2 CIT DNAH11

2.28e-0612064711EFO_0004458
Diseasefree cholesterol measurement, very low density lipoprotein cholesterol measurement

SUGP1 CYP2A6 HNF1A FUT2 DNAH11

2.34e-05215475EFO_0008317, EFO_0008591
Diseasevery low density lipoprotein cholesterol measurement, lipid measurement

SUGP1 CYP2A6 HNF1A FUT2 DNAH11

2.62e-05220475EFO_0004529, EFO_0008317
Diseasevery low density lipoprotein cholesterol measurement, phospholipid measurement

SUGP1 CYP2A6 HNF1A FUT2 DNAH11

3.17e-05229475EFO_0004639, EFO_0008317
DiseaseRENAL CELL CARCINOMA, NONPAPILLARY

HNF1A HNF1B

5.19e-057472144700
Diseaselevel of Sphingomyelin (d36:2) in blood serum

ANKRD17 HNF1A

5.19e-057472OBA_2045177
DiseaseNonpapillary renal cell carcinoma

HNF1A HNF1B

5.19e-057472cv:CN074294
Diseasecomparative body size at age 10, self-reported

NPC1 AKAP6 HOXB3 ZNF536 MLIP FUT2

5.26e-05420476EFO_0009819
Diseasevery low density lipoprotein cholesterol measurement

SUGP1 CYP2A6 HNF1A FUT2 DNAH11

5.79e-05260475EFO_0008317
Diseasetotal phospholipids in lipoprotein particles measurement

SUGP1 HNF1A FUT2

8.39e-0553473EFO_0022315
Diseaselevel of Sterol ester (27:1/16:1) in blood serum

HNF1A DENND1A

8.88e-059472OBA_2045190
Diseasenon-high density lipoprotein cholesterol measurement

NPC1 SUGP1 CYP2A6 HOXB3 HNF1A FUT2 DNAH11

1.27e-04713477EFO_0005689
Diseasealcohol consumption measurement

NPC1 AKAP6 HNF1A MLIP BCAR3 FUT2 MED1 CIT DENND1A

1.29e-041242479EFO_0007878
Diseasenicotine metabolite ratio

CYP2A6 CYP2A7

1.62e-0412472EFO_0007794
DiseaseMaturity onset diabetes mellitus in young

HNF1A HNF1B

2.23e-0414472C0342276
Diseaseserum urea measurement

TMEM266 HNF1A HNF1B FUT2

2.64e-04195474EFO_0009795
Diseaseomega-6 polyunsaturated fatty acid measurement

SUGP1 HNF1A FUT2 DNAH11

2.75e-04197474EFO_0005680
DiseaseTremor, Rubral

NPC1 EGR3

2.94e-0416472C0750940
DiseaseAtaxia, Appendicular

NPC1 EGR3

2.94e-0416472C0750937
DiseaseAtaxia, Motor

NPC1 EGR3

2.94e-0416472C0278161
DiseaseAbnormal coordination

NPC1 EGR3

2.94e-0416472C0520966
Diseaselevel of Sterol ester (27:1/18:1) in blood serum

ANKRD17 HNF1A

2.94e-0416472OBA_2045195
DiseaseAtaxia, Truncal

NPC1 EGR3

2.94e-0416472C0427190
DiseaseMonogenic diabetes

HNF1A HNF1B

2.94e-0416472C3888631
DiseaseAtaxia, Sensory

NPC1 EGR3

2.94e-0416472C0240991
Diseaseliver fibrosis measurement

SUGP1 HNF1A BCAR3

3.53e-0486473EFO_0010576
Diseasecholelithiasis

HNF1A HNF1B FUT2

3.78e-0488473EFO_0004799
Diseaselevel of Sphingomyelin (d38:2) in blood serum

ANKRD17 HNF1A

4.17e-0419472OBA_2045179
Diseasecaffeine metabolite measurement

CYP2A6 CYP2A7

4.17e-0419472EFO_0007872
Diseaseserum alanine aminotransferase measurement

NPC1 SUGP1 CYP2A6 HNF1A HNF1B MLIP FUT2

4.22e-04869477EFO_0004735
Diseasetotal cholesterol measurement, very low density lipoprotein cholesterol measurement

SUGP1 CYP2A6 HNF1A FUT2

4.46e-04224474EFO_0004574, EFO_0008317
Diseasedisease of metabolism (implicated_via_orthology)

LDHAL6B LDHAL6A

5.12e-0421472DOID:0014667 (implicated_via_orthology)
DiseaseCoronary heart disease

HNF1A DNAH11

6.70e-0424472C0010068
Diseasegallstones

HNF1A HNF1B FUT2

6.88e-04108473EFO_0004210
Diseaseremnant cholesterol measurement

SUGP1 HNF1A FUT2

6.88e-04108473EFO_0010815
DiseaseAtaxia

NPC1 EGR3

7.28e-0425472C0004134
Diseaselevel of Sterol ester (27:1/18:2) in blood serum

ANKRD17 HNF1A

7.88e-0426472OBA_2045194
Diseaseantihyperlipidemic drug use measurement

HNF1A FUT2 DNAH11

8.25e-04115473EFO_0803367
Diseaseomega-3 polyunsaturated fatty acid measurement

SUGP1 HNF1A COL11A1

8.89e-04118473EFO_0010119
DiseaseTYPE 2 DIABETES MELLITUS

HNF1A HNF1B

9.14e-0428472125853
DiseaseType 2 diabetes mellitus

HNF1A HNF1B

9.14e-0428472cv:C0011860
Diseaselow density lipoprotein cholesterol measurement, phospholipid measurement

CYP2A6 FUT2 DNAH11

9.33e-04120473EFO_0004611, EFO_0004639
Diseasecreatinine measurement

TMEM266 HNF1A MLIP BCAR3 MED1 UNC80 USP32

9.40e-04995477EFO_0004518
DiseaseCleft palate, cleft lip

STK3 ZNF536 COL11A1 PAX7

1.01e-03279474EFO_0003959, HP_0000175
DiseasePapillary Renal Cell Carcinoma

HNF1A HNF1B ZNF536

1.12e-03128473C1306837
DiseaseRenal Cell Carcinoma

HNF1A HNF1B ZNF536

1.12e-03128473C0007134
DiseaseSarcomatoid Renal Cell Carcinoma

HNF1A HNF1B ZNF536

1.12e-03128473C1266043
DiseaseChromophobe Renal Cell Carcinoma

HNF1A HNF1B ZNF536

1.12e-03128473C1266042
DiseaseCollecting Duct Carcinoma of the Kidney

HNF1A HNF1B ZNF536

1.12e-03128473C1266044
Diseaseesterified cholesterol measurement

ANKRD17 HNF1A FUT2

1.12e-03128473EFO_0008589
Diseasecholine measurement

SUGP1 HNF1A FUT2

1.18e-03130473EFO_0010116
Diseaseprostate cancer (implicated_via_orthology)

PAX7 TUSC3

1.27e-0333472DOID:10283 (implicated_via_orthology)
Diseasefree cholesterol measurement, low density lipoprotein cholesterol measurement

ANKRD17 HNF1A FUT2

1.37e-03137473EFO_0004611, EFO_0008591
Diseasephospholipid measurement

SUGP1 HNF1A FUT2

1.45e-03140473EFO_0004639

Protein segments in the cluster

PeptideGeneStartEntry
AQPSPMQHQFSMPTV

ACOT8

131

O14734
EMFSSVMKHLPGPQQ

CYP2A6

221

P11509
RNMPVNHQFPLASSM

BCAR3

11

O75815
HVVLNKNMPFTSGNM

DNAH11

621

Q96DT5
RPMSDPGVFSQHQAM

ANKRD17

2486

O75179
NPHQNMNRGMEFIAP

C7orf33

71

Q8WU49
GMQMHPVQSQASFPK

CECR2

1446

Q9BXF3
FQGKPPFMTQQQMSP

CIT

31

O14578
EMLHGMAPQQKHGQQ

MLIP

191

Q5VWP3
MNPAAPSNHMNPVSN

PAX7

366

P23759
QGSMVTQHGKPMFTQ

LDB1

161

Q86U70
SLMNHPVIPMANKFS

MAN2A1

1011

Q16706
EHMKFPMGTQTNPAR

COL11A1

1591

P12107
LNPKQFMTMFPHTPD

MGAT5B

421

Q3V5L5
TMDLQHGSPFTKMPN

LDHAL6B

111

Q9BYZ2
MFGTPQEHRNMPQAD

NCOA5

271

Q9HCD5
QSPFMATMAQLQSPH

HNF1A

486

P20823
DFPVHGMEPMNNATK

NPC1

211

O15118
PQMSNPGQFTAPQMK

NCOA6

391

Q14686
IGSFGNHPSMMTINN

BICRAL

216

Q6AI39
EMFSSVMKHLPGPQQ

CYP2A13

221

Q16696
EMFSSVMKHLPGPQQ

CYP2A7

221

P20853
AKMNGRPAFIPAQMH

FUT2

86

Q10981
NDMGSIPEHKPFQGM

EGR3

201

Q06889
PQPMQSTAGFMNALH

HOXB3

266

P14651
SMPNLFGQMPMGTHT

DENND1A

891

Q8TEH3
FFKLQQHQSMPGTMA

EXOC1

536

Q9NV70
PVSSMAGNTKNHPML

MED1

631

Q15648
ATQFMPDPKLMDHGQ

APOOL

241

Q6UXV4
GMVGLSKMHAQPPQQ

MN1

281

Q10571
LMQQSPGSHMAQQPF

HNF1B

486

P35680
PGSHMAQQPFMAAVT

HNF1B

491

P35680
SHLMKRMSQNFPNGG

SGSM2

861

O43147
HMPFLKNNPKVTGMT

AKAP6

1301

Q13023
SGMVAPSNIFHQPMA

ANKHD1

2446

Q8IWZ3
APPKSGKMNMNILHQ

SUGP1

21

Q8IWZ8
NQNMHEPFPMSKNVF

STK3

411

Q13188
QQLNMNSAPTFMHFP

TUSC3

141

Q13454
MVAMGTHANAQMPTP

TEX13D

186

A0A0J9YY54
PMTAPQMSRCDQGHK

UNC80

2421

Q8N2C7
VMPQKMVPLGDSNSH

TEX13C

426

A0A0J9YWL9
EKAHVPMSGQPMGSQ

ZNF536

66

O15090
PQNIQDQAKHMGVMA

PLIN2

336

Q99541
KNFTNGMVNGHMPSL

USP6

851

P35125
TEKNFTNGMVNGHMP

USP32

1051

Q8NFA0
MAVAPSFNMTNPQPA

TMEM266

1

Q2M3C6
NSVNMPGMVTHIKAP

TRIO

1091

O75962
VAMQMPVSTSHPNKQ

KIAA1958

306

Q8N8K9
QHGSPFMKMPNIVSS

LDHAL6A

66

Q6ZMR3