Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcesskeratinization

KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

2.54e-0887436GO:0031424
GeneOntologyBiologicalProcesskeratinocyte differentiation

KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

2.51e-06189436GO:0030216
GeneOntologyBiologicalProcessepidermal cell differentiation

KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

2.57e-05284436GO:0009913
GeneOntologyBiologicalProcessepithelium development

NKX3-2 TGIF1 KRT24 SLC12A2 KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F ZIC2 MSGN1

3.14e-0514694312GO:0060429
GeneOntologyBiologicalProcessskin development

KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

1.16e-04373436GO:0043588
GeneOntologyBiologicalProcessepidermis development

KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

3.65e-04461436GO:0008544
GeneOntologyBiologicalProcessepithelial cell differentiation

NKX3-2 KRT24 KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

3.78e-04870438GO:0030855
GeneOntologyBiologicalProcesspositive regulation of long-term synaptic depression

ADCY8 IQSEC2

3.80e-0414432GO:1900454
HumanPhenoExpressive language delay

TGIF1 KMT2D SRCAP ZIC2

8.70e-0656134HP:0002474
HumanPhenoLanguage delay

TGIF1 KMT2D SRCAP ZIC2

8.70e-0656134HP:0002336
HumanPhenoProboscis

TGIF1 KMT2D ZIC2

1.68e-0521133HP:0012806
HumanPhenoLobar holoprosencephaly

TGIF1 KMT2D ZIC2

3.26e-0526133HP:0006870
HumanPhenoAbnormality of upper lip vermillion

TGIF1 KMT2D AMMECR1 SRCAP TRIO IQSEC2 ZIC2

5.25e-05464137HP:0011339
HumanPhenoPrecocious puberty

TGIF1 KMT2D SRCAP IQSEC2 ZIC2

6.24e-05186135HP:0000826
HumanPhenoEarly onset of sexual maturation

TGIF1 KMT2D SRCAP IQSEC2 ZIC2

6.73e-05189135HP:0100000
HumanPhenoCongenital malformation of the great arteries

TGIF1 KMT2D AMMECR1 SRCAP TRIO NEK8 ZIC2

1.23e-04529137HP:0011603
HumanPhenoAbnormal nasal septum morphology

TGIF1 KMT2D SRCAP TRIO

1.51e-04115134HP:0000419
HumanPhenoTented upper lip vermilion

TGIF1 KMT2D IQSEC2 ZIC2

1.56e-04116134HP:0010804
HumanPhenoSleep-wake cycle disturbance

TGIF1 IQSEC2 ZIC2

1.73e-0445133HP:0006979
HumanPhenoAnteverted nares

TGIF1 KMT2D AMMECR1 SRCAP TRIO IQSEC2 ZIC2

1.75e-04559137HP:0000463
HumanPhenoUpturned nose

TGIF1 KMT2D AMMECR1 SRCAP TRIO IQSEC2 ZIC2

1.75e-04559137HP:0000427
HumanPhenoChoanal atresia

TGIF1 KMT2D SLC12A2 ZIC2

1.96e-04123134HP:0000453
HumanPhenoJoint dislocation

NKX3-2 TGIF1 KMT2D SLC12A2 SRCAP ZIC2

2.09e-04390136HP:0001373
HumanPhenoAbnormal nostril morphology

TGIF1 KMT2D AMMECR1 SRCAP TRIO IQSEC2 ZIC2

2.10e-04575137HP:0005288
HumanPhenoAbnormality of dental eruption

KMT2D AMMECR1 SRCAP TRIO IQSEC2

2.10e-04240135HP:0006292
HumanPhenoAlobar holoprosencephaly

KMT2D ZIC2

2.14e-049132HP:0006988
HumanPhenoSemilobar holoprosencephaly

TGIF1 ZIC2

2.14e-049132HP:0002507
HumanPhenoAplasia/Hypoplasia involving the nose

TGIF1 KMT2D SRCAP TRIO IQSEC2 ZIC2

2.44e-04401136HP:0009924
HumanPhenoShort philtrum

TGIF1 SRCAP TRIO IQSEC2 ZIC2

2.69e-04253135HP:0000322
HumanPhenoChoanal atresia or stenosis

TGIF1 KMT2D SLC12A2 ZIC2

2.72e-04134134HP:0000416
HumanPhenoAbnormal choanae morphology

TGIF1 KMT2D SLC12A2 ZIC2

2.72e-04134134HP:0000415
HumanPhenoNarrow nasal bridge

TGIF1 SRCAP ZIC2

2.83e-0453133HP:0000446
HumanPhenoAbnormal number of teeth

TGIF1 KMT2D AMMECR1 SRCAP TRIO ZIC2

3.19e-04421136HP:0006483
HumanPhenoHip dislocation

NKX3-2 TGIF1 KMT2D SLC12A2 ZIC2

3.23e-04263135HP:0002827
HumanPhenoMedian cleft palate

TGIF1 KMT2D ZIC2

3.33e-0456133HP:0009099
HumanPhenoMedian cleft upper lip

TGIF1 KMT2D ZIC2

3.33e-0456133HP:0000161
HumanPhenoMedian cleft lip and palate

TGIF1 KMT2D ZIC2

3.33e-0456133HP:0008501
HumanPhenoLow hanging columella

KMT2D SRCAP TRIO

3.33e-0456133HP:0009765
HumanPhenoHypertrichosis

KMT2D AMMECR1 SRCAP TRIO IQSEC2 ZIC2

3.36e-04425136HP:0000998
HumanPhenoAbsent speech

TGIF1 SLC12A2 SRCAP TRIO IQSEC2 ZIC2

3.87e-04436136HP:0001344
HumanPhenoImpulsivity

TGIF1 SRCAP IQSEC2 ZIC2

4.09e-04149134HP:0100710
HumanPhenoAbnormal morphology of the nasal alae

TGIF1 KMT2D AMMECR1 SRCAP TRIO IQSEC2 ZIC2

4.10e-04639137HP:0000429
HumanPhenoCoarctation of aorta

TGIF1 KMT2D SRCAP ZIC2

4.20e-04150134HP:0001680
HumanPhenoAbnormal soft palate morphology

TGIF1 KMT2D AMMECR1 IQSEC2 ZIC2

5.01e-04289135HP:0100736
HumanPhenoOligodontia

KMT2D SRCAP TRIO

5.18e-0465133HP:0000677
HumanPhenoDeficiency of speech development

TGIF1 SLC12A2 SRCAP TRIO IQSEC2 ZIC2

5.38e-04463136HP:0002116
HumanPhenoAnteriorly placed anus

TGIF1 KMT2D ZIC2

5.91e-0468133HP:0001545
HumanPhenoConstipation

TGIF1 SLC12A2 SRCAP TRIO IQSEC2 ZIC2

5.97e-04472136HP:0002019
HumanPhenoBifid uvula

TGIF1 KMT2D AMMECR1 ZIC2

6.32e-04167134HP:0000193
HumanPhenoAbnormal femur morphology

NKX3-2 AMMECR1 SLC12A2 SRCAP NEK8

6.33e-04304135HP:0002823
HumanPhenoMidnasal atresia or stenosis

TGIF1 ZIC2

7.07e-0416132HP:0010642
HumanPhenoAbnormality of the midnasal cavity

TGIF1 ZIC2

7.07e-0416132HP:0010641
HumanPhenoMidnasal stenosis

TGIF1 ZIC2

7.07e-0416132HP:0010644
HumanPhenoRhombencephalosynapsis

TGIF1 ZIC2

7.07e-0416132HP:0031913
HumanPhenoAbnormal hip joint morphology

NKX3-2 TGIF1 KMT2D SLC12A2 SRCAP ZIC2

7.31e-04490136HP:0001384
HumanPhenoMacrocephaly

NKX3-2 TGIF1 SLC12A2 SRCAP TRIO ZIC2

7.39e-04491136HP:0000256
HumanPhenoLower extremity joint dislocation

NKX3-2 TGIF1 KMT2D SLC12A2 ZIC2

7.79e-04318135HP:0030311
HumanPhenoFrontoethmoidal encephalocele

TGIF1 ZIC2

8.00e-0417132HP:0007330
HumanPhenoAbnormal nasal cavity morphology

TGIF1 ZIC2

8.00e-0417132HP:0010640
HumanPhenoIncreased head circumference

NKX3-2 TGIF1 SLC12A2 SRCAP TRIO ZIC2

8.16e-04500136HP:0040194
HumanPhenoAbnormality of the thigh

NKX3-2 AMMECR1 SLC12A2 SRCAP NEK8

8.25e-04322135HP:0001439
HumanPhenoAbnormal synovial membrane morphology

NKX3-2 TGIF1 KMT2D SLC12A2 SRCAP ZIC2

8.42e-04503136HP:0005262
HumanPhenoShort nose

TGIF1 KMT2D TRIO IQSEC2 ZIC2

8.61e-04325135HP:0003196
HumanPhenoCleft upper lip

TGIF1 KMT2D IQSEC2 ZIC2

8.93e-04183134HP:0000204
HumanPhenoAnterior encephalocele

TGIF1 ZIC2

8.99e-0418132HP:0007035
HumanPhenoTetralogy of Fallot

TGIF1 KMT2D SRCAP ZIC2

9.31e-04185134HP:0001636
HumanPhenoHoloprosencephaly

TGIF1 KMT2D ZIC2

9.52e-0480133HP:0001360
HumanPhenoGastroesophageal reflux

TGIF1 KMT2D SLC12A2 SRCAP IQSEC2 ZIC2

9.77e-04517136HP:0002020
HumanPhenoAbnormal morphology of the great vessels

TGIF1 KMT2D AMMECR1 SRCAP TRIO NEK8 ZIC2

9.90e-04736137HP:0030962
HumanPhenoAbnormality of primary teeth

KMT2D SRCAP IQSEC2

1.02e-0382133HP:0006481
HumanPhenoOverfolded helix

KMT2D AMMECR1 TRIO

1.02e-0382133HP:0000396
HumanPhenoAplasia of the falx cerebri

TGIF1 ZIC2

1.11e-0320132HP:0010654
HumanPhenoPoor speech

TGIF1 TRIO IQSEC2 ZIC2

1.13e-03195134HP:0002465
HumanPhenoSynophrys

AMMECR1 TRIO IQSEC2 ZIC2

1.13e-03195134HP:0000664
HumanPhenoAbnormal uvula morphology

TGIF1 KMT2D AMMECR1 ZIC2

1.18e-03197134HP:0000172
HumanPhenoDeviation of finger

NKX3-2 KMT2D AMMECR1 SRCAP TRIO IQSEC2

1.20e-03537136HP:0004097
HumanPhenoButterfly vertebrae

NKX3-2 KMT2D

1.23e-0321132HP:0003316
HumanPhenoAbnormality of the dentition

TGIF1 KMT2D AMMECR1 SLC12A2 SRCAP TRIO IQSEC2 ZIC2

1.32e-031030138HP:0000164
HumanPhenoAbnormally folded helix

KMT2D AMMECR1 TRIO

1.34e-0390133HP:0008544
HumanPhenoCyclopia

TGIF1 ZIC2

1.35e-0322132HP:0009914
HumanPhenoSingle naris

TGIF1 ZIC2

1.35e-0322132HP:0009932
HumanPhenoCentral diabetes insipidus

TGIF1 ZIC2

1.35e-0322132HP:0000863
HumanPhenoRenal hypoplasia/aplasia

TGIF1 KMT2D SRCAP IQSEC2 ZIC2

1.36e-03359135HP:0008678
HumanPhenoFacial hypertrichosis

AMMECR1 TRIO IQSEC2 ZIC2

1.39e-03206134HP:0002219
HumanPhenoRenal agenesis

TGIF1 KMT2D SRCAP ZIC2

1.47e-03209134HP:0000104
HumanPhenoEctopic anus

TGIF1 KMT2D ZIC2

1.48e-0393133HP:0004397
HumanPhenoDeviation of the hand or of fingers of the hand

NKX3-2 KMT2D AMMECR1 SRCAP TRIO IQSEC2

1.55e-03564136HP:0009484
HumanPhenoAspiration pneumonia

TGIF1 KMT2D ZIC2

1.57e-0395133HP:0011951
HumanPhenoAplasia/Hypoplasia of the nares

TGIF1 ZIC2

1.61e-0324132HP:0100597
HumanPhenoTube feeding

TGIF1 SRCAP TRIO ZIC2

1.63e-03215134HP:0033454
HumanPhenoAbnormal columella morphology

KMT2D SRCAP TRIO

1.67e-0397133HP:0009929
HumanPhenoAbnormal heart rate variability

TGIF1 ZIC2

1.75e-0325132HP:0031860
HumanPhenoMedial flaring of the eyebrow

AMMECR1 TRIO IQSEC2 ZIC2

2.03e-03228134HP:0010747
HumanPhenoAbnormality of the falx cerebri

TGIF1 ZIC2

2.04e-0327132HP:0010653
HumanPhenoSingle central incisor

TGIF1 ZIC2

2.04e-0327132HP:0001573
HumanPhenoPersistence of primary teeth

KMT2D SRCAP

2.04e-0327132HP:0006335
HumanPhenoSolitary median maxillary central incisor

TGIF1 ZIC2

2.04e-0327132HP:0006315
HumanPhenoUnderdeveloped nasal alae

KMT2D SRCAP TRIO

2.04e-03104133HP:0000430
HumanPhenoGastrostomy tube feeding in infancy

TGIF1 TRIO ZIC2

2.04e-03104133HP:0011471
HumanPhenoOromotor apraxia

TGIF1 ZIC2

2.19e-0328132HP:0007301
HumanPhenoAbnormal dura mater morphology

TGIF1 ZIC2

2.19e-0328132HP:0010652
HumanPhenoDepressed nasal tip

TGIF1 KMT2D

2.19e-0328132HP:0000437
HumanPhenoHyperacusis

TRIO IQSEC2

2.19e-0328132HP:0010780
HumanPhenoCleft soft palate

TGIF1 KMT2D AMMECR1 ZIC2

2.38e-03238134HP:0000185
HumanPhenoDepressed nasal bridge

TGIF1 KMT2D AMMECR1 TRIO IQSEC2 ZIC2

2.39e-03612136HP:0005280
HumanPhenoFlattened nasal bridge

TGIF1 KMT2D AMMECR1 TRIO IQSEC2 ZIC2

2.39e-03612136HP:0000425
HumanPhenoDelayed speech and language development

TGIF1 KMT2D AMMECR1 SLC12A2 SRCAP TRIO IQSEC2 ZIC2

2.40e-031123138HP:0000750
HumanPhenoAbnormality of the chin

KMT2D SLC12A2 SRCAP TRIO IQSEC2

2.44e-03409135HP:0000306
DomainLCE

LCE1C LCE1B LCE1E LCE1A LCE1F

3.08e-1017435PF14672
DomainLCE

LCE1C LCE1B LCE1E LCE1A LCE1F

3.08e-1017435IPR028205
DomainSPRR/LCE

LCE1C LCE1B LCE1E LCE1A LCE1F

4.81e-0928435IPR026075
DomainSET

PRDM8 KMT2D

5.03e-0346432SM00317
DomainSET_dom

PRDM8 KMT2D

5.91e-0350432IPR001214
DomainSET

PRDM8 KMT2D

5.91e-0350432PS50280
DomainUBQ-conjugating_enzyme/RWD

DHX57 UBE2O

6.62e-0353432IPR016135
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT24 KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

6.02e-09129297M27649
PathwayREACTOME_KERATINIZATION

KRT24 KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

2.18e-07217297M27640
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

KMT2D KRT24 TRIO KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F ZIC2 MSGN1

7.00e-0514322911M509
Pubmed

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

LCE1C LCE1B LCE1E LCE1A LCE1F

7.47e-112245515854049
Pubmed

Differentially expressed late constituents of the epidermal cornified envelope.

LCE1C LCE1B LCE1E LCE1A LCE1F

9.53e-112345511698679
Pubmed

Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes.

LCE1C LCE1B LCE1E LCE1A

4.40e-091645417410201
Pubmed

Assessment of community efforts to advance network-based prediction of protein-protein interactions.

INTS5 KRT24 KRT79 LCE1C LCE1B LCE1E LCE1A LCE1F

1.32e-0663045836949045
Pubmed

DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity.

SLC12A2 DISC1

1.64e-06245223921125
Pubmed

Reciprocal regulation of Rag expression in thymocytes by the zinc-finger proteins, Zfp608 and Zfp609.

ZNF609 ZNF608

1.64e-06245223076336
Pubmed

BCOR modulates transcriptional activity of a subset of glucocorticoid receptor target genes involved in cell growth and mobility.

ZNF609 ZNF608 ARID5B

4.02e-062445333722704
Pubmed

Holoprosencephaly Overview

TGIF1 KMT2D ZIC2

4.56e-062545320301702
Pubmed

Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling.

TRIO DISC1

4.91e-06345221422296
Pubmed

New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases.

TGIF1 ZIC2

9.81e-06445221940735
Pubmed

Association between LCE gene polymorphisms and psoriasis vulgaris among Mongolians from Inner Mongolia.

LCE1C LCE1B

9.81e-06445229397434
Pubmed

Utilizing prospective sequence analysis of SHH, ZIC2, SIX3 and TGIF in holoprosencephaly probands to describe the parameters limiting the observed frequency of mutant gene×gene interactions.

TGIF1 ZIC2

9.81e-06445222310223
Pubmed

The unfolding clinical spectrum of holoprosencephaly due to mutations in SHH, ZIC2, SIX3 and TGIF genes.

TGIF1 ZIC2

9.81e-06445220531442
Pubmed

Molecular screening of SHH, ZIC2, SIX3, and TGIF genes in patients with features of holoprosencephaly spectrum: Mutation review and genotype-phenotype correlations.

TGIF1 ZIC2

9.81e-06445215221788
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

SRPK3 IFRD1 MTCL1 SLC12A2 TRIO PPM1H IQSEC2 MOB2

1.31e-0586145836931259
Pubmed

Link between the causative genes of holoprosencephaly: Zic2 directly regulates Tgif1 expression.

TGIF1 ZIC2

1.63e-05545229391420
Pubmed

Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.

GATAD1 ZNF609 KMT2D ZNF608 ARID5B

2.49e-0526845533640491
Pubmed

Synaptic, transcriptional and chromatin genes disrupted in autism.

DHX57 TRIO

3.42e-05745225363760
Pubmed

Interaction network of human early embryonic transcription factors.

GATAD1 ZNF609 KMT2D ZNF608 ARID5B

8.93e-0535145538297188
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

DHX57 SRCAP

1.47e-041445228263302
Pubmed

A census of human transcription factors: function, expression and evolution.

NKX3-2 GATAD1 TGIF1 KMT2D ZBTB7B ZIC2 MSGN1

1.54e-0490845719274049
Pubmed

The DNA sequence and biological annotation of human chromosome 1.

ZBTB7B LCE1C LCE1B LCE1E LCE1A DISC1 LCE1F

3.35e-04103145716710414
Pubmed

Central roles of the roof plate in telencephalic development and holoprosencephaly.

TGIF1 ZIC2

3.72e-042245216855091
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

TRIO KRT79 DISC1

4.07e-0411145322558309
Pubmed

Human transcription factor protein interaction networks.

GATAD1 ZNF609 UBE2O KMT2D EYA3 SRCAP ZNF608 ARID5B

4.42e-04142945835140242
Pubmed

Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer.

IFRD1 KRT79

4.82e-042545231462707
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

INTS5 KMT2D SRCAP TRIO NEK8 MTG2 TBC1D9

5.07e-04110545735748872
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

TGIF1 ZNF609 CPHXL SRCAP ZBTB7B ARID5B

5.81e-0480845620412781
Pubmed

Impact of cytosine methylation on DNA binding specificities of human transcription factors.

NKX3-2 TGIF1 ZNF784 ZBTB7B MSGN1

6.70e-0454445528473536
Pubmed

Genome-wide association study identifies eight loci associated with blood pressure.

PRDM8 ARID5B

7.92e-043245219430483
Pubmed

An AUTS2-Polycomb complex activates gene expression in the CNS.

ZNF609 ZNF608

1.12e-033845225519132
Pubmed

Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

TGIF1 ADCY8

1.18e-033945224709693
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

GATAD1 ZNF609 INTS5 KMT2D SRCAP ZBTB7B ARID5B

1.28e-03129445730804502
InteractionTRIM42 interactions

SPAG8 LCE1C LCE1B LCE1E LCE1A NEK8 LCE1F

2.70e-08149437int:TRIM42
InteractionKRTAP10-1 interactions

DHX57 AMMECR1 LCE1C LCE1B LCE1E LCE1A LCE1F

3.25e-08153437int:KRTAP10-1
InteractionLCE3B interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

4.47e-0846435int:LCE3B
InteractionKRTAP2-3 interactions

DHX57 LCE1C LCE1B LCE1E LCE1A LCE1F

4.95e-0895436int:KRTAP2-3
InteractionKRTAP2-4 interactions

DHX57 LCE1C LCE1B LCE1E LCE1A LCE1F

7.15e-08101436int:KRTAP2-4
InteractionKRTAP12-4 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

9.25e-0853435int:KRTAP12-4
InteractionKRTAP10-8 interactions

DHX57 INTS5 AMMECR1 SPAG8 LCE1C LCE1B LCE1E LCE1A LCE1F

1.39e-07401439int:KRTAP10-8
InteractionKRTAP5-2 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.06e-0762435int:KRTAP5-2
InteractionKRTAP12-1 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.23e-0763435int:KRTAP12-1
InteractionKRTAP5-4 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.23e-0763435int:KRTAP5-4
InteractionKRTAP10-11 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.42e-0764435int:KRTAP10-11
InteractionKRTAP5-11 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.82e-0766435int:KRTAP5-11
InteractionKRTAP5-3 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.82e-0766435int:KRTAP5-3
InteractionKRTAP10-10 interactions

LCE1C LCE1B LCE1E LCE1F

3.04e-0727434int:KRTAP10-10
InteractionLCE1E interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

3.28e-0768435int:LCE1E
InteractionLCE2D interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

5.02e-0774435int:LCE2D
InteractionKRTAP4-5 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

5.74e-0776435int:KRTAP4-5
InteractionLCE1C interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

6.13e-0777435int:LCE1C
InteractionKRTAP12-3 interactions

DHX57 LCE1C LCE1B LCE1E LCE1A LCE1F

6.37e-07146436int:KRTAP12-3
InteractionLCE4A interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

7.43e-0780435int:LCE4A
InteractionKRTAP4-4 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

7.90e-0781435int:KRTAP4-4
InteractionLCE2B interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

7.90e-0781435int:LCE2B
InteractionLCE1A interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

9.48e-0784435int:LCE1A
InteractionLCE1B interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.01e-0685435int:LCE1B
InteractionKRTAP10-5 interactions

DHX57 LCE1C LCE1B LCE1E LCE1A LCE1F

1.09e-06160436int:KRTAP10-5
InteractionLCE2C interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.20e-0688435int:LCE2C
InteractionKRTAP10-6 interactions

DHX57 LCE1B LCE1E LCE1A LCE1F

1.20e-0688435int:KRTAP10-6
InteractionLCE5A interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.34e-0690435int:LCE5A
InteractionLCE1F interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.49e-0692435int:LCE1F
InteractionKRTAP4-11 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.49e-0692435int:KRTAP4-11
InteractionKRTAP5-6 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.66e-0694435int:KRTAP5-6
InteractionKRTAP9-8 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.25e-06100435int:KRTAP9-8
InteractionKRTAP1-5 interactions

LCE1B LCE1E LCE1A LCE1F

3.26e-0648434int:KRTAP1-5
InteractionRGS17 interactions

LCE1B LCE1E LCE1A LCE1F

3.26e-0648434int:RGS17
InteractionSPRY1 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

3.77e-06111435int:SPRY1
InteractionRGS20 interactions

LCE1B LCE1E LCE1A NEK8 LCE1F

5.09e-06118435int:RGS20
InteractionADAMTSL4 interactions

AMMECR1 LCE1C LCE1B LCE1A NEK8 LCE1F

6.36e-06217436int:ADAMTSL4
InteractionNFIX interactions

GATAD1 ZNF609 KMT2D SRCAP ZBTB7B ZNF608

8.23e-06227436int:NFIX
InteractionKRTAP4-2 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

8.81e-06132435int:KRTAP4-2
InteractionKRTAP10-9 interactions

DHX57 LCE1C LCE1B LCE1E LCE1A LCE1F

1.16e-05241436int:KRTAP10-9
InteractionKRTAP9-3 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.17e-05140435int:KRTAP9-3
InteractionLCE2A interactions

LCE1C LCE1B LCE1A LCE1F

1.40e-0569434int:LCE2A
InteractionLCE1D interactions

LCE1C LCE1B LCE1E LCE1F

1.49e-0570434int:LCE1D
InteractionKRTAP5-7 interactions

LCE1B LCE1E LCE1A LCE1F

1.57e-0571434int:KRTAP5-7
InteractionKRTAP9-2 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

1.59e-05149435int:KRTAP9-2
InteractionCHIC2 interactions

LCE1C LCE1B LCE1A LCE1F

1.76e-0573434int:CHIC2
InteractionKRTAP4-12 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.30e-05161435int:KRTAP4-12
InteractionKRTAP6-3 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

2.30e-05161435int:KRTAP6-3
InteractionSMCP interactions

LCE1B LCE1E LCE1A LCE1F

2.40e-0579434int:SMCP
InteractionSOX7 interactions

ZNF609 KMT2D ZNF608 ARID5B

2.78e-0582434int:SOX7
InteractionMORF4L2 interactions

GATAD1 UBE2O SRCAP ZBTB7B DISC1

2.83e-05168435int:MORF4L2
InteractionGSC interactions

ZNF609 KMT2D ZNF608 ARID5B

3.52e-0587434int:GSC
InteractionKRTAP4-1 interactions

LCE1B LCE1A LCE1F

3.90e-0531433int:KRTAP4-1
InteractionHNF1B interactions

GATAD1 ZNF609 KMT2D ZNF608 ARID5B

5.09e-05190435int:HNF1B
InteractionMYOD1 interactions

IFRD1 ZNF609 UBE2O KMT2D ZNF608

5.61e-05194435int:MYOD1
InteractionSPRY3 interactions

LCE1B LCE1A LCE1F

5.65e-0535433int:SPRY3
InteractionFOXL1 interactions

IFRD1 ZNF609 KMT2D ZNF608 ARID5B

5.90e-05196435int:FOXL1
InteractionKRTAP5-9 interactions

LCE1C LCE1B LCE1E LCE1A LCE1F

6.96e-05203435int:KRTAP5-9
InteractionKRTAP11-1 interactions

SPAG8 LCE1B LCE1A LCE1F

8.19e-05108434int:KRTAP11-1
InteractionPLA2G10 interactions

SPAG8 LCE1C LCE1A LCE1F

9.77e-05113434int:PLA2G10
InteractionP4HA3 interactions

MTCL1 SRCAP ZBTB7B DISC1

9.77e-05113434int:P4HA3
InteractionFUCA2 interactions

LCE1B LCE1E LCE1A

1.05e-0443433int:FUCA2
InteractionKLF3 interactions

GATAD1 ZNF609 KMT2D ZNF608 ARID5B

1.20e-04228435int:KLF3
InteractionALPP interactions

LCE1C LCE1B LCE1E LCE1F

1.36e-04123434int:ALPP
InteractionKRTAP12-2 interactions

LCE1C LCE1B LCE1A LCE1F

1.58e-04128434int:KRTAP12-2
InteractionFBLN1 interactions

LCE1C LCE1B LCE1A LCE1F

1.63e-04129434int:FBLN1
InteractionGATAD2B interactions

GATAD1 ZNF609 ZNF784 ZBTB7B DISC1

1.68e-04245435int:GATAD2B
InteractionEFEMP2 interactions

AMMECR1 LCE1C LCE1E LCE1A

2.00e-04136434int:EFEMP2
InteractionNAV1 interactions

BORCS6 TRIO DISC1 PPM1H

2.83e-04149434int:NAV1
InteractionMDFI interactions

TGIF1 ZNF784 LCE1B LCE1A LCE1F ZIC2

2.85e-04430436int:MDFI
InteractionHNF4A interactions

GATAD1 ZNF609 KMT2D SRCAP ZNF608

2.87e-04275435int:HNF4A
InteractionNTAQ1 interactions

BORCS6 LCE1C LCE1E LCE1F MTG2 MOB2

2.88e-04431436int:NTAQ1
InteractionSPRY2 interactions

LCE1C LCE1B LCE1A LCE1F

3.05e-04152434int:SPRY2
InteractionVWC2 interactions

LCE1C LCE1A LCE1F

3.13e-0462433int:VWC2
InteractionVASN interactions

LCE1C LCE1B LCE1A LCE1F

3.71e-04160434int:VASN
InteractionCRCT1 interactions

LCE1C LCE1A LCE1F

3.77e-0466433int:CRCT1
InteractionKRTAP10-7 interactions

DHX57 LCE1B LCE1E LCE1A LCE1F

3.84e-04293435int:KRTAP10-7
InteractionLCE3C interactions

LCE1B LCE1A LCE1F

3.94e-0467433int:LCE3C
InteractionHDAC2 interactions

GATAD1 DHX57 IFRD1 ZNF609 ZBTB7B TRIO PPM1H ARID5B

4.25e-04865438int:HDAC2
InteractionKANSL2 interactions

ZNF609 UBE2O ZNF608

4.48e-0470433int:KANSL2
InteractionSP7 interactions

ZNF609 KMT2D EYA3 ZNF608 ARID5B

4.55e-04304435int:SP7
InteractionHDAC1 interactions

NKX3-2 GATAD1 TGIF1 IFRD1 ZNF609 KMT2D ZBTB7B ZNF608 ARID5B

4.60e-041108439int:HDAC1
InteractionEGR2 interactions

GATAD1 ZNF609 KMT2D ZNF608

4.77e-04171434int:EGR2
InteractionMACO1 interactions

LCE1C LCE1E LCE1A LCE1F

5.21e-04175434int:MACO1
InteractionTLX1 interactions

ZNF609 KMT2D EYA3 ZNF608

5.21e-04175434int:TLX1
InteractionTEAD1 interactions

ZNF609 KMT2D ZNF608 ARID5B

5.32e-04176434int:TEAD1
InteractionSETD1B interactions

ZNF609 KMT2D ZNF608

5.49e-0475433int:SETD1B
InteractionYME1L1 interactions

UBE2O ZBTB7B NEK8 TBC1D9

6.28e-04184434int:YME1L1
InteractionKRTAP1-3 interactions

LCE1B LCE1E LCE1A LCE1F

6.28e-04184434int:KRTAP1-3
InteractionKRTAP3-2 interactions

LCE1B LCE1A LCE1F

6.39e-0479433int:KRTAP3-2
InteractionSNX18 interactions

ZNF784 ZBTB7B DISC1

6.87e-0481433int:SNX18
InteractionCYSRT1 interactions

INTS5 LCE1C LCE1B LCE1E LCE1A LCE1F

7.09e-04511436int:CYSRT1
InteractionKLF5 interactions

ZNF609 KMT2D ZBTB7B ZNF608

7.81e-04195434int:KLF5
InteractionPAX2 interactions

ZNF609 KMT2D ZNF608

7.91e-0485433int:PAX2
InteractionIRF4 interactions

ZNF609 KMT2D ZNF608

7.91e-0485433int:IRF4
InteractionGATA2 interactions

ZNF609 KMT2D ZNF608 ARID5B

8.42e-04199434int:GATA2
InteractionINTS6L interactions

INTS5 ZBTB7B

9.10e-0421432int:INTS6L
InteractionHOXA1 interactions

AMMECR1 LCE1C LCE1B LCE1A LCE1F

9.28e-04356435int:HOXA1
InteractionSOX10 interactions

ZNF609 KMT2D ZNF608

9.95e-0492433int:SOX10
InteractionFOXI1 interactions

ZNF609 KMT2D ZNF608

9.95e-0492433int:FOXI1
Cytoband1q21.3

ZBTB7B LCE1C LCE1B LCE1E LCE1A LCE1F

1.57e-091174461q21.3
CytobandEnsembl 112 genes in cytogenetic band chr1q21

ZBTB7B LCE1C LCE1B LCE1E LCE1A LCE1F

2.38e-06404446chr1q21
GeneFamilyLate cornified envelope proteins

LCE1C LCE1B LCE1E LCE1A LCE1F

1.06e-1018325627
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

PRDM8 KMT2D

1.64e-0334322487
CoexpressionGSE2585_CTEC_VS_THYMIC_MACROPHAGE_DN

GATAD1 TGIF1 SRPK3 KMT2D SLC12A2 PPM1H

8.57e-07199436M6264
CoexpressionJARDIM_PERASSI_TRIPLE_NEGATIVE_BREAST_CANCER_MOUSE_XENOGRAFT_MELATONIN_UP

LCE1C LCE1B LCE1E LCE1A

1.26e-0649434MM452
CoexpressionGSE26727_WT_VS_KLF2_KO_LPS_STIM_MACROPHAGE_UP

GATAD1 SRCAP TRIO DISC1 TBC1D9

1.83e-05199435M8301
CoexpressionHOLLERN_SQUAMOUS_BREAST_TUMOR

KRT79 LCE1C LCE1B LCE1E LCE1A

2.06e-05204435MM966
ToppCellfacs-Skin-Skin_Anagen-18m-Epithelial-epidermal_cell|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IFRD1 LCE1B LCE1E LCE1F

2.54e-051734440f9c1d3298e59e6d22bb3306f0f445f490be8bbd
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

EYA3 ZNF608 SDK1 TBC1D9

3.30e-05185444d602a9b35e86e6f2a14a58e40fc4fb97f5fa3b08
ToppCellControl-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

SNED1 ZNF608 TRIO TBC1D9

3.44e-051874444e64be635f445276e71f2937f33f041c3a4204ab
ToppCellCOPD-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

SNED1 TRIO TBC1D9 ARID5B

3.67e-051904441e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MTCL1 ZNF608 TRIO SDK1

3.74e-051914441cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellproximal-Hematologic-Platelet/Megakaryocyte|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIO DISC1 NEK8 PPM1H

3.82e-05192444522d1bb15edf1d6006b80289bd3baadb99584ae8
ToppCellproximal-Hematologic-Platelet/Megakaryocyte-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIO DISC1 NEK8 PPM1H

3.82e-0519244457899a905ca3e336bb7f31edc6418a2546b9891a
ToppCellproximal-3-Hematologic-Platelet/Megakaryocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

TRIO DISC1 NEK8 PPM1H

3.82e-05192444f5f83dec37dff32a0c471cb05d23d13b0b0ad0c9
ToppCellCF-Lymphoid-B_cell|Lymphoid / Disease state, Lineage and Cell class

SNED1 TRIO TBC1D9 ARID5B

3.90e-051934447ebf20344a9a154fd2cffa281526867fcf0aded3
ToppCell10x3'2.3-week_17-19-Mesenchymal_fibro-stroma-endosteal_fibroblast|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

NKX3-2 SNED1 ADCY8 ZIC2

3.98e-0519444469362e13158033de44f90f3773db6c0f27de8cb3
Drugbeta-damascenone

LCE1C LCE1B LCE1F

1.24e-0524433ctd:C075388
DrugClomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; PC3; HT_HG-U133A

KMT2D EYA3 SPAG8 TRIO ADCY8

2.93e-051914354487_UP
DrugIndapamide [26807-65-8]; Down 200; 10.6uM; PC3; HT_HG-U133A

NKX3-2 ZNF609 SRCAP TRIO TBC1D9

3.16e-051944354335_DN
DrugOxamniquine [21738-42-1]; Up 200; 14.4uM; MCF7; HT_HG-U133A

SNED1 SRPK3 ZNF609 SPAG8 TRIO

3.24e-051954354124_UP
DrugSpaglumic acid [4910-46-7]; Down 200; 13.2uM; HL60; HT_HG-U133A

ZNF609 SRCAP DISC1 PPM1H TBC1D9

3.24e-051954352962_DN
DrugAcetaminophen [103-90-2]; Up 200; 26.4uM; HL60; HT_HG-U133A

SNED1 SRPK3 EYA3 SPAG8 TRIO

3.32e-051964353025_UP
DrugFlufenamic acid [530-78-9]; Down 200; 14.2uM; MCF7; HT_HG-U133A

BORCS6 ZNF609 INTS5 KRT24 DISC1

3.40e-051974352267_DN
DiseaseHOLOPROSENCEPHALY 5

TGIF1 ZIC2

6.22e-063432C1864827
Diseaseholoprosencephaly (is_implicated_in)

TGIF1 ZIC2

5.78e-058432DOID:4621 (is_implicated_in)
DiseaseHoloprosencephaly sequence

TGIF1 ZIC2

9.27e-0510432cv:C0079541
DiseaseVaricose veins

SLC12A2 NEK8 MOB2 ARID5B

1.79e-04193434HP_0002619
DiseaseAlobar Holoprosencephaly

TGIF1 ZIC2

2.15e-0415432C0431363
DiseaseLobar Holoprosencephaly

TGIF1 ZIC2

2.46e-0416432C0431362
DiseaseSemilobar Holoprosencephaly

TGIF1 ZIC2

2.46e-0416432C0751617
DiseaseHoloprosencephaly

TGIF1 ZIC2

2.78e-0417432C0079541
DiseaseNeurodevelopmental Disorders

SRCAP TRIO IQSEC2

3.41e-0493433C1535926
Diseaseenergy expenditure

MTCL1 PPM1H

7.11e-0427432EFO_0005109
DiseaseTinnitus

KRT79 SDK1 ARID5B

9.07e-04130433HP_0000360
DiseaseHyperkinesia, Generalized

DISC1 ADCY8

1.00e-0332432C0751217
DiseaseHyperkinesia

DISC1 ADCY8

1.00e-0332432C3887506
DiseaseCongenital small ears

NKX3-2 KMT2D

1.64e-0341432C0152423
Diseasevisceral:abdominal adipose tissue ratio measurement

ADCY8 ARID5B

2.63e-0352432EFO_0803318
Diseasewaist circumference

TRIO DISC1 ADCY8 TBC1D9

3.47e-03429434EFO_0004342

Protein segments in the cluster

PeptideGeneStartEntry
IHGHRGGSGSGSGGS

ADCY8

51

P40145
GGDGDHSSTGAVGGH

CCDC144NL

171

Q6NUI1
GCGGDGSSGSGDAHS

DISC1

311

Q9NRI5
STDGFSGSGGSGSHG

EYA3

386

Q99504
ADGDTGSHGLGGQTC

MTCL1

971

Q9Y4B5
VLCSGAGGVHSGGSG

MOB2

206

Q70IA6
HGGASSGGSEGCSVG

MSGN1

71

A6NI15
SGGSEGCSVGGASGL

MSGN1

76

A6NI15
GHSGSQTGCGSSKGA

ERVS71-1

106

P61550
CGGGIDGGGSSVTTS

IQSEC2

436

Q5JU85
SSGSGGGAHCGPGTG

KRT79

41

Q5XKE5
GSGSNGCLGHGSLTD

NEK8

416

Q86SG6
CSVGGGFGGASGSGT

KRT24

71

Q2M2I5
GAHVSALCSGAGGGG

NKX3-2

171

P78367
CGGAGSSGSAESGAG

BORCS6

176

Q96GS4
HHCTGRGGAGSGGAG

GATAD1

31

Q8WUU5
GRSHASKSHGSGGGG

DHX57

26

Q6P158
HRGSSAGGGGSGAAA

IFRD1

11

O00458
PSGGSSCCGGDSGQH

LCE1A

91

Q5T7P2
GGSSCCGGGSGQHSG

LCE1B

101

Q5T7P3
GGSSCCGGGSGQHSG

LCE1C

101

Q5T751
GGSSCCGGGSGQHSG

LCE1E

101

Q5T753
AGSSCCGGGSGQHSG

LCE1F

101

Q5T754
ETSGGDTAGAGRCGG

SDK1

56

Q7Z5N4
AMGYGGDTGSGHSGS

CPHXL

221

A0A1W2PPM1
VLGSSSGAGHGSGSG

SPAG8

146

Q99932
SGAGHGSGSGSGPGC

SPAG8

151

Q99932
QSLSSGSGSGGGGGH

PRDM8

281

Q9NQV8
CGGNGGAGASCFHSE

MTG2

81

Q9H4K7
CVHGGAGGGAGSSGG

INTS5

251

Q6P9B9
AGDESSCGTGGGTHR

SRCAP

2366

Q6ZRS2
GTHASSGGNATGLGG

SNED1

196

Q8TER0
GSGSTSSSGCHPGGA

SRPK3

311

Q9UPE1
SGGGGGASSSSHCSG

AMMECR1

21

Q9Y4X0
SEGSKAAHGGHSGGG

ARID5B

1051

Q14865
GVGSPHCSGSGGGGS

TGIF1

11

Q15583
GSGTATGGAGAGVCE

ZBTB7B

76

O15156
SGSEHGGGSCGGSDL

PPM1H

21

Q9ULR3
EGSSLHSGGGGGSGH

SLC12A2

181

P55011
KEGGSGGSGPSCHQG

TBC1D9

1076

Q6ZT07
RGSSGCSEAGGAGHE

UBE2O

96

Q9C0C9
VVGGGGSCSSVGGAS

ZNF609

1331

O15014
GASPFHCGGTGSGSV

ZNF608

246

Q9ULD9
HCGGTGSGSVAAAGE

ZNF608

251

Q9ULD9
GGSGHSGGPSSCGGA

TRIO

2316

O75962
VSAVHRGGGSGSGGA

ZIC2

471

O95409
GGGSGTAGGHSGLSS

ZIC2

511

O95409
SSAAEGSGSGCGVGD

ZNF784

291

Q8NCA9
AGGGSHGQLGSGSSS

KMT2D

4111

O14686