Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ribose phosphate diphosphokinase activity	PRPS2 PRPS1	5.17e-05	5	46	2	GO:0004749
GeneOntologyMolecularFunction	spectrin binding	GBP1 GBP2 PTPRN	6.51e-05	34	46	3	GO:0030507
GeneOntologyMolecularFunction	diphosphotransferase activity	PRPS2 PRPS1	7.74e-05	6	46	2	GO:0016778
GeneOntologyMolecularFunction	GDP binding	PRPS2 GBP1 GBP2 PRPS1	9.22e-05	103	46	4	GO:0019003
GeneOntologyMolecularFunction	GDP phosphatase activity	GBP1 GBP2	3.38e-04	12	46	2	GO:0004382
GeneOntologyMolecularFunction	ATP-dependent DNA damage sensor activity	PMS2P1 PMS2P5	9.61e-04	20	46	2	GO:0140664
GeneOntologyMolecularFunction	nucleoside diphosphate phosphatase activity	GBP1 GBP2	9.61e-04	20	46	2	GO:0017110
GeneOntologyMolecularFunction	AMP binding	PRPS2 PRPS1	1.06e-03	21	46	2	GO:0016208
GeneOntologyMolecularFunction	DNA damage sensor activity	PMS2P1 PMS2P5	1.39e-03	24	46	2	GO:0140612
GeneOntologyMolecularFunction	ATP-dependent activity	PMS2P1 PMS2P5 TTF2 TOMM20 ATAD3B ATAD3C	2.71e-03	614	46	6	GO:0140657
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	PMS2P1 PMS2P5 TTF2	3.12e-03	127	46	3	GO:0008094
GeneOntologyBiologicalProcess	intestinal D-glucose absorption	EZR SLC5A1	3.04e-05	4	47	2	GO:0001951
GeneOntologyBiologicalProcess	positive regulation of AIM2 inflammasome complex assembly	GBP1 GBP2	3.04e-05	4	47	2	GO:0140973
GeneOntologyBiologicalProcess	intestinal hexose absorption	EZR SLC5A1	5.06e-05	5	47	2	GO:0106001
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate biosynthetic process	PRPS2 PRPS1	7.58e-05	6	47	2	GO:0006015
GeneOntologyBiologicalProcess	5-phosphoribose 1-diphosphate metabolic process	PRPS2 PRPS1	7.58e-05	6	47	2	GO:0046391
GeneOntologyBiologicalProcess	regulation of AIM2 inflammasome complex assembly	GBP1 GBP2	7.58e-05	6	47	2	GO:0140971
GeneOntologyBiologicalProcess	AIM2 inflammasome complex assembly	GBP1 GBP2	1.41e-04	8	47	2	GO:0140970
GeneOntologyBiologicalProcess	positive regulation of early endosome to late endosome transport	EZR MSN	1.81e-04	9	47	2	GO:2000643
GeneOntologyBiologicalProcess	positive regulation of pyroptotic inflammatory response	GBP1 GBP2	1.81e-04	9	47	2	GO:0140639
GeneOntologyBiologicalProcess	cytolysis in another organism	GBP1 GBP2	1.81e-04	9	47	2	GO:0051715
GeneOntologyBiologicalProcess	regulation of protein localization to early endosome	EZR MSN	2.26e-04	10	47	2	GO:1902965
GeneOntologyBiologicalProcess	positive regulation of protein localization to early endosome	EZR MSN	2.26e-04	10	47	2	GO:1902966
GeneOntologyBiologicalProcess	cytolysis	GBP1 GBP2	3.31e-04	12	47	2	GO:0019835
GeneOntologyBiologicalProcess	positive regulation of protein localization to endosome	EZR MSN	4.54e-04	14	47	2	GO:1905668
GeneOntologyBiologicalProcess	regulation of protein localization to endosome	EZR MSN	5.24e-04	15	47	2	GO:1905666
GeneOntologyBiologicalProcess	protein localization to early endosome	EZR MSN	5.98e-04	16	47	2	GO:1902946
GeneOntologyBiologicalProcess	adhesion of symbiont to host	GBP1 GBP2	9.41e-04	20	47	2	GO:0044406
GeneOntologyBiologicalProcess	regulation of early endosome to late endosome transport	EZR MSN	9.41e-04	20	47	2	GO:2000641
GeneOntologyBiologicalProcess	establishment of epithelial cell apical/basal polarity	EZR MSN	1.04e-03	21	47	2	GO:0045198
GeneOntologyCellularComponent	ribose phosphate diphosphokinase complex	PRPS2 PRPS1	4.93e-05	5	47	2	GO:0002189
GeneOntologyCellularComponent	host cell part	GBP1 GBP2	7.38e-05	6	47	2	GO:0033643
GeneOntologyCellularComponent	host intracellular part	GBP1 GBP2	7.38e-05	6	47	2	GO:0033646
GeneOntologyCellularComponent	host cell cytoplasm part	GBP1 GBP2	7.38e-05	6	47	2	GO:0033655
GeneOntologyCellularComponent	host intracellular region	GBP1 GBP2	7.38e-05	6	47	2	GO:0043656
GeneOntologyCellularComponent	host cell cytoplasm	GBP1 GBP2	7.38e-05	6	47	2	GO:0030430
GeneOntologyCellularComponent	symbiont-containing vacuole	GBP1 GBP2	7.38e-05	6	47	2	GO:0020003
GeneOntologyCellularComponent	symbiont-containing vacuole membrane	GBP1 GBP2	7.38e-05	6	47	2	GO:0020005
GeneOntologyCellularComponent	symbiont cell surface	GBP1 GBP2	1.37e-04	8	47	2	GO:0106139
GeneOntologyCellularComponent	other organism part	GBP1 GBP2	1.76e-04	9	47	2	GO:0044217
GeneOntologyCellularComponent	mismatch repair complex	PMS2P1 PMS2P5	2.69e-04	11	47	2	GO:0032300
GeneOntologyCellularComponent	uropod	EZR MSN	4.43e-04	14	47	2	GO:0001931
GeneOntologyCellularComponent	host cellular component	GBP1 GBP2	5.10e-04	15	47	2	GO:0018995
GeneOntologyCellularComponent	cell trailing edge	EZR MSN	5.10e-04	15	47	2	GO:0031254
GeneOntologyCellularComponent	cell tip	EZR MSN	6.59e-04	17	47	2	GO:0051286
GeneOntologyCellularComponent	cell pole	EZR MSN	9.16e-04	20	47	2	GO:0060187
GeneOntologyCellularComponent	microvillus membrane	EZR MSN	3.30e-03	38	47	2	GO:0031528
MousePheno	decreased circulating cholesterol level	DENND5B TRMT1 ATAD3B ATAD3C FOXA3 PLEKHF2 NR5A2	9.91e-05	397	39	7	MP:0005179
MousePheno	decreased cholesterol level	DENND5B TRMT1 ATAD3B ATAD3C FOXA3 PLEKHF2 NR5A2	1.37e-04	418	39	7	MP:0003983
MousePheno	decreased sterol level	DENND5B TRMT1 ATAD3B ATAD3C FOXA3 PLEKHF2 NR5A2	1.43e-04	421	39	7	MP:0012225
Domain	DUF3523	ATAD3B ATAD3C	1.70e-05	3	45	2	PF12037
Domain	PRPP_SYNTHASE	PRPS2 PRPS1	1.70e-05	3	45	2	PS00114
Domain	DUF3523	ATAD3B ATAD3C	1.70e-05	3	45	2	IPR021911
Domain	PRib_PP_synth_CS	PRPS2 PRPS1	1.70e-05	3	45	2	IPR000842
Domain	ERM_C_dom	EZR MSN	3.40e-05	4	45	2	IPR011259
Domain	ERM	EZR MSN	3.40e-05	4	45	2	IPR011174
Domain	ERM	EZR MSN	3.40e-05	4	45	2	PF00769
Domain	Rib-P_diPkinase	PRPS2 PRPS1	5.65e-05	5	45	2	IPR005946
Domain	Pribosyl_synth	PRPS2 PRPS1	5.65e-05	5	45	2	PF14572
Domain	Pribosyltran_N	PRPS2 PRPS1	5.65e-05	5	45	2	IPR029099
Domain	Pribosyltran_N	PRPS2 PRPS1	5.65e-05	5	45	2	PF13793
Domain	HELP	EML5 EML6	8.46e-05	6	45	2	PF03451
Domain	HELP	EML5 EML6	8.46e-05	6	45	2	IPR005108
Domain	Moesin_tail	EZR MSN	1.18e-04	7	45	2	IPR008954
Domain	GBP_C	GBP1 GBP2	2.52e-04	10	45	2	PF02841
Domain	Guanylate-bd_C	GBP1 GBP2	3.08e-04	11	45	2	IPR003191
Domain	GBP	GBP1 GBP2	3.08e-04	11	45	2	PF02263
Domain	Pribosyltran	PRPS2 PRPS1	3.08e-04	11	45	2	PF00156
Domain	G_GB1_RHD3_dom	GBP1 GBP2	3.08e-04	11	45	2	IPR030386
Domain	Guanylate-bd_N	GBP1 GBP2	3.08e-04	11	45	2	IPR015894
Domain	G_GB1_RHD3	GBP1 GBP2	3.08e-04	11	45	2	PS51715
Domain	-	PRPS2 PRPS1	3.69e-04	12	45	2	3.40.50.2020
Domain	PRTase-like	PRPS2 PRPS1	3.69e-04	12	45	2	IPR029057
Domain	PRibTrfase_dom	PRPS2 PRPS1	3.69e-04	12	45	2	IPR000836
Domain	VitD_rcpt	NR6A1 NR5A2	5.07e-04	14	45	2	IPR000324
Domain	Apc4_WD40_dom	EML5 EML6	1.05e-03	20	45	2	IPR024977
Domain	ANAPC4_WD40	EML5 EML6	1.05e-03	20	45	2	PF12894
Domain	PLAT	DENND5B LOXHD1	1.16e-03	21	45	2	PF01477
Domain	Ez/rad/moesin-like	EZR MSN	1.16e-03	21	45	2	IPR000798
Domain	PLAT	DENND5B LOXHD1	1.16e-03	21	45	2	PS50095
Domain	PLAT/LH2_dom	DENND5B LOXHD1	1.16e-03	21	45	2	IPR001024
Domain	-	DENND5B LOXHD1	1.16e-03	21	45	2	2.60.60.20
Domain	FERM_CS	EZR MSN	1.51e-03	24	45	2	IPR019747
Domain	FERM_C	EZR MSN	1.78e-03	26	45	2	PF09380
Domain	FERM_C	EZR MSN	1.92e-03	27	45	2	SM01196
Domain	FERM_PH-like_C	EZR MSN	1.92e-03	27	45	2	IPR018980
Domain	FYVE	PLEKHF2 PLEKHF1	2.21e-03	29	45	2	PF01363
Domain	FYVE	PLEKHF2 PLEKHF1	2.21e-03	29	45	2	SM00064
Domain	-	EZR ARHGEF1 PLEKHF2 PLEKHF1 MSN	2.41e-03	391	45	5	2.30.29.30
Domain	FERM_N	EZR MSN	2.86e-03	33	45	2	IPR018979
Domain	FERM_N	EZR MSN	2.86e-03	33	45	2	PF09379
Domain	Znf_FYVE-rel	PLEKHF2 PLEKHF1	3.03e-03	34	45	2	IPR017455
Domain	PH_dom-like	EZR ARHGEF1 PLEKHF2 PLEKHF1 MSN	3.48e-03	426	45	5	IPR011993
Domain	Znf_FYVE	PLEKHF2 PLEKHF1	3.78e-03	38	45	2	IPR000306
Domain	P-loop_NTPase	ASPM GBP1 TTF2 GBP2 ATAD3B TRANK1 ATAD3C	3.90e-03	848	45	7	IPR027417
Domain	ZF_FYVE	PLEKHF2 PLEKHF1	4.18e-03	40	45	2	PS50178
Domain	FERM_M	EZR MSN	5.49e-03	46	45	2	PF00373
Domain	zf-C4	NR6A1 NR5A2	5.49e-03	46	45	2	PF00105
Domain	NUCLEAR_REC_DBD_1	NR6A1 NR5A2	5.49e-03	46	45	2	PS00031
Domain	Znf_hrmn_rcpt	NR6A1 NR5A2	5.49e-03	46	45	2	IPR001628
Domain	Nuclear_hrmn_rcpt	NR6A1 NR5A2	5.49e-03	46	45	2	IPR001723
Domain	ZnF_C4	NR6A1 NR5A2	5.49e-03	46	45	2	SM00399
Domain	NUCLEAR_REC_DBD_2	NR6A1 NR5A2	5.49e-03	46	45	2	PS51030
Domain	-	NR6A1 NR5A2	5.73e-03	47	45	2	1.10.565.10
Domain	HOLI	NR6A1 NR5A2	5.97e-03	48	45	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	NR6A1 NR5A2	5.97e-03	48	45	2	IPR000536
Domain	Hormone_recep	NR6A1 NR5A2	5.97e-03	48	45	2	PF00104
Domain	FERM_central	EZR MSN	6.21e-03	49	45	2	IPR019748
Domain	FERM_domain	EZR MSN	6.21e-03	49	45	2	IPR000299
Domain	-	EZR MSN	6.21e-03	49	45	2	1.20.80.10
Domain	FERM_1	EZR MSN	6.46e-03	50	45	2	PS00660
Domain	FERM_2	EZR MSN	6.46e-03	50	45	2	PS00661
Domain	Band_41_domain	EZR MSN	6.46e-03	50	45	2	IPR019749
Domain	B41	EZR MSN	6.46e-03	50	45	2	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	EZR MSN	6.46e-03	50	45	2	IPR014352
Domain	FERM_3	EZR MSN	6.46e-03	50	45	2	PS50057
Domain	AAA	ATAD3B ATAD3C	6.97e-03	52	45	2	PF00004
Pubmed	Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes.	PMS2P1 PMS2P2 PMS2P5	8.60e-08	7	48	3	7980603
Pubmed	Genomic organization of the human PMS2 gene family.	PMS2P1 PMS2P2 PMS2P5	4.04e-07	11	48	3	8586419
Pubmed	Immunohistochemical assessment of ezrin and moesin in colorectal carcinoma.	EZR MSN	1.87e-06	2	48	2	27042764
Pubmed	Differential expression of interferon inducible protein: Guanylate binding protein (GBP1 & GBP2) in severe dengue.	GBP1 GBP2	1.87e-06	2	48	2	36460216
Pubmed	Expression of ezrin and moesin related to invasion, metastasis and prognosis of laryngeal squamous cell carcinoma.	EZR MSN	1.87e-06	2	48	2	25299115
Pubmed	Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin.	EZR MSN	1.87e-06	2	48	2	9213396
Pubmed	Dimerization and its role in GMP formation by human guanylate binding proteins.	GBP1 GBP2	1.87e-06	2	48	2	20923658
Pubmed	Ezrin and moesin expression within the developing human cerebrum and tuberous sclerosis-associated cortical tubers.	EZR MSN	1.87e-06	2	48	2	12111362
Pubmed	[Increased activity of PRPP synthetase].	PRPS2 PRPS1	1.87e-06	2	48	2	18409517
Pubmed	Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site.	EZR MSN	1.87e-06	2	48	2	7579708
Pubmed	Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins.	GBP1 GBP2	1.87e-06	2	48	2	23086406
Pubmed	Tissue-differential expression of two distinct genes for phosphoribosyl pyrophosphate synthetase and existence of the testis-specific transcript.	PRPS2 PRPS1	1.87e-06	2	48	2	2537655
Pubmed	Ezrin has properties to self-associate at the plasma membrane.	EZR MSN	1.87e-06	2	48	2	7844168
Pubmed	Expression of ezrin and moesin in primary breast carcinoma and matched lymph node metastases.	EZR MSN	1.87e-06	2	48	2	28624994
Pubmed	Commensal Escherichia coli reduces epithelial apoptosis through IFN-alphaA-mediated induction of guanylate binding protein-1 in human and murine models of developing intestine.	GBP1 GBP2	1.87e-06	2	48	2	20483731
Pubmed	Moesin: a member of the protein 4.1-talin-ezrin family of proteins.	EZR MSN	1.87e-06	2	48	2	1924289
Pubmed	Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins.	EZR MSN	1.87e-06	2	48	2	8248180
Pubmed	PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness.	PRPS2 PRPS1	1.87e-06	2	48	2	33493137
Pubmed	The interferon (IFN)-induced GTPase, mGBP-2. Role in IFN-gamma-induced murine fibroblast proliferation.	GBP1 GBP2	5.59e-06	3	48	2	11726669
Pubmed	A gene family consisting of ezrin, radixin and moesin. Its specific localization at actin filament/plasma membrane association sites.	EZR MSN	5.59e-06	3	48	2	1429901
Pubmed	The ezrin-like family of tyrosine kinase substrates: receptor-specific pattern of tyrosine phosphorylation and relationship to malignant transformation.	EZR MSN	5.59e-06	3	48	2	8479753
Pubmed	ERM Proteins at the Crossroad of Leukocyte Polarization, Migration and Intercellular Adhesion.	EZR MSN	5.59e-06	3	48	2	32098334
Pubmed	GBP2 inhibits pathological angiogenesis in the retina via the AKT/mTOR/VEGFA axis.	GBP1 GBP2	5.59e-06	3	48	2	38636926
Pubmed	Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins.	EZR MSN	5.59e-06	3	48	2	18261459
Pubmed	Ezrin, radixin, and moesin are phosphorylated in response to 2-methoxyestradiol and modulate endothelial hyperpermeability.	EZR MSN	5.59e-06	3	48	2	21659656
Pubmed	Expression, localization, and binding activity of the ezrin/radixin/moesin proteins in the mouse testis.	EZR MSN	5.59e-06	3	48	2	19064715
Pubmed	Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition.	EZR MSN	5.59e-06	3	48	2	17046996
Pubmed	Activation of PKC induces leukocyte adhesion by the dephosphorylation of ERM.	EZR MSN	5.59e-06	3	48	2	31843195
Pubmed	Ezrin, Radixin, and Moesin (ERM) proteins function as pleiotropic regulators of human immunodeficiency virus type 1 infection.	EZR MSN	5.59e-06	3	48	2	18295815
Pubmed	Dmoesin controls actin-based cell shape and polarity during Drosophila melanogaster oogenesis.	EZR MSN	5.59e-06	3	48	2	12360288
Pubmed	Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.	EZR MSN	5.59e-06	3	48	2	21864676
Pubmed	CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contacts.	EZR MSN	5.59e-06	3	48	2	9616160
Pubmed	Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa.	GBP1 GBP2	5.59e-06	3	48	2	30062052
Pubmed	Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation.	EZR MSN	5.59e-06	3	48	2	14613898
Pubmed	Domain motions, dimerization, and membrane interactions of the murine guanylate binding protein 2.	GBP1 GBP2	5.59e-06	3	48	2	36639389
Pubmed	Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.	EZR MSN	5.59e-06	3	48	2	22132106
Pubmed	Expression of phosphoribosyl pyrophosphate synthetase genes in U87 glioma cells with ERN1 knockdown: effect of hypoxia and endoplasmic reticulum stress.	PRPS2 PRPS1	5.59e-06	3	48	2	25816608
Pubmed	Promoter regions of the human X-linked housekeeping genes PRPS1 and PRPS2 encoding phosphoribosylpyrophosphate synthetase subunit I and II isoforms.	PRPS2 PRPS1	5.59e-06	3	48	2	1314091
Pubmed	The cytoplasmic tail of L-selectin interacts with members of the Ezrin-Radixin-Moesin (ERM) family of proteins: cell activation-dependent binding of Moesin but not Ezrin.	EZR MSN	5.59e-06	3	48	2	11706008
Pubmed	Dynamics and function of ERM proteins during cytokinesis in human cells.	EZR MSN	5.59e-06	3	48	2	28889652
Pubmed	Increased phosphorylation of ezrin/radixin/moesin proteins contributes to proliferation of rheumatoid fibroblast-like synoviocytes.	EZR MSN	5.59e-06	3	48	2	21278069
Pubmed	Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.	EZR MSN	5.59e-06	3	48	2	26555866
Pubmed	Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages.	GBP1 GBP2	5.59e-06	3	48	2	26416908
Pubmed	Control of adipogenesis by ezrin, radixin and moesin-dependent biomechanics remodeling.	EZR MSN	5.59e-06	3	48	2	23116763
Pubmed	ATAD3 is a limiting factor in mitochondrial biogenesis and adipogenesis of white adipocyte-like 3T3-L1 cells.	ATAD3B ATAD3C	5.59e-06	3	48	2	38923254
Pubmed	[ATAD3, a vital membrane-bound mitochondrial ATPase involved in tumor progression].	ATAD3B ATAD3C	5.59e-06	3	48	2	22192748
Pubmed	Induction of ezrin-radixin-moesin molecules after cryogenic traumatic brain injury of the mouse cortex.	EZR MSN	5.59e-06	3	48	2	21451358
Pubmed	Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7.	GBP1 GBP2	5.59e-06	3	48	2	32354743
Pubmed	[Study of the correlation of papillary thyroid carcinoma's invasion with Ezrin, Moesin and E-Cadherin].	EZR MSN	5.59e-06	3	48	2	22177047
Pubmed	GTPase properties of the interferon-induced human guanylate-binding protein 2.	GBP1 GBP2	5.59e-06	3	48	2	8706832
Pubmed	Human ezrin-moesin-radixin proteins modulate hepatitis C virus infection.	EZR MSN	5.59e-06	3	48	2	23703860
Pubmed	Molecular mechanism of c-Myc and PRPS1/2 against thiopurine resistance in Burkitt's lymphoma.	PRPS2 PRPS1	5.59e-06	3	48	2	32391636
Pubmed	ATAD3A has a scaffolding role regulating mitochondria inner membrane structure and protein assembly.	ATAD3B ATAD3C	5.59e-06	3	48	2	34936866
Pubmed	The interferon-induced GTPase, mGBP-2, confers resistance to paclitaxel-induced cytotoxicity without inhibiting multinucleation.	GBP1 GBP2	5.59e-06	3	48	2	16914101
Pubmed	Guanylate binding proteins contained in the murine chromosome 3 are important to control mycobacterial infection.	GBP1 GBP2	5.59e-06	3	48	2	32620042
Pubmed	Partial reconstitution of mammalian phosphoribosylpyrophosphate synthetase in Escherichia coli cells. Coexpression of catalytic subunits with the 39-kDa associated protein leads to formation of soluble multimeric complexes of various compositions.	PRPS2 PRPS1	5.59e-06	3	48	2	9366267
Pubmed	[Guanylate-binding protein 2 regulates the maturation of mouse dendritic cells induced by β-glucan].	GBP1 GBP2	5.59e-06	3	48	2	29089068
Pubmed	Ezrin-radixin-moesin family proteins are involved in parvovirus replication and spreading.	EZR MSN	5.59e-06	3	48	2	19321616
Pubmed	Pseudomonas aeruginosa ExoS ADP-ribosyltransferase inhibits ERM phosphorylation.	EZR MSN	5.59e-06	3	48	2	16889625
Pubmed	Deciphering brain-specific transcriptomic expression of Ezr, Rad and Msn genes in the development of Mus musculus.	EZR MSN	5.59e-06	3	48	2	29906485
Pubmed	Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.	EZR MSN	5.59e-06	3	48	2	25486435
Pubmed	ATAD3 gene cluster deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.	ATAD3B ATAD3C	5.59e-06	3	48	2	28549128
Pubmed	Mitochondria-associated membrane formation in hormone-stimulated Leydig cell steroidogenesis: role of ATAD3.	ATAD3B ATAD3C	5.59e-06	3	48	2	25375035
Pubmed	Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.	EZR MSN	5.59e-06	3	48	2	20679347
Pubmed	The EBP50-moesin interaction involves a binding site regulated by direct masking on the FERM domain.	EZR MSN	5.59e-06	3	48	2	15020681
Pubmed	The GTPase activity of murine guanylate-binding protein 2 (mGBP2) controls the intracellular localization and recruitment to the parasitophorous vacuole of Toxoplasma gondii.	GBP1 GBP2	5.59e-06	3	48	2	22730319
Pubmed	Differential expression and distribution of ezrin, radixin and moesin in human natural killer cells.	EZR MSN	5.59e-06	3	48	2	12385025
Pubmed	Are ERM (ezrin/radixin/moesin) proteins targets for autoantibodies in demyelinating neuropathies?	EZR MSN	5.59e-06	3	48	2	25286001
Pubmed	Sequential binding of ezrin and moesin to L-selectin regulates monocyte protrusive behaviour during transendothelial migration.	EZR MSN	5.59e-06	3	48	2	29777033
Pubmed	Inhibition of VSV and EMCV replication by the interferon-induced GTPase, mGBP-2: differential requirement for wild-type GTP binding domain.	GBP1 GBP2	5.59e-06	3	48	2	15717119
Pubmed	Nuclear ERM (ezrin, radixin, moesin) proteins: regulation by cell density and nuclear import.	EZR MSN	5.59e-06	3	48	2	15149851
Pubmed	Osmotic cell shrinkage activates ezrin/radixin/moesin (ERM) proteins: activation mechanisms and physiological implications.	EZR MSN	5.59e-06	3	48	2	17977945
Pubmed	Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS.	EZR MSN	5.59e-06	3	48	2	15252013
Pubmed	Effect of knockdown of ezrin, radixin, and moesin on P-glycoprotein function in HepG2 cells.	EZR MSN	5.59e-06	3	48	2	21837648
Pubmed	Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target.	GBP1 GBP2	5.59e-06	3	48	2	35383115
Pubmed	Murine guanylate binding protein 2 (mGBP2) controls Toxoplasma gondii replication.	GBP1 GBP2	5.59e-06	3	48	2	23248289
Pubmed	Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.	GBP1 GBP2	5.59e-06	3	48	2	1715024
Pubmed	Cloning of cDNAs for human phosphoribosylpyrophosphate synthetases 1 and 2 and X chromosome localization of PRPS1 and PRPS2 genes.	PRPS2 PRPS1	5.59e-06	3	48	2	1962753
Pubmed	ERM-Dependent Assembly of T Cell Receptor Signaling and Co-stimulatory Molecules on Microvilli prior to Activation.	EZR MSN	5.59e-06	3	48	2	32160548
Pubmed	GBP1 Facilitates Indoleamine 2,3-Dioxygenase Extracellular Secretion to Promote the Malignant Progression of Lung Cancer.	GBP1 GBP2	5.59e-06	3	48	2	33552086
Pubmed	The amino-terminal domains of the ezrin, radixin, and moesin (ERM) proteins bind advanced glycation end products, an interaction that may play a role in the development of diabetic complications.	EZR MSN	5.59e-06	3	48	2	12734202
Pubmed	ERM stable knockdown by siRNA reduced in vitro migration and invasion of human SGC-7901 cells.	EZR MSN	5.59e-06	3	48	2	21352885
Pubmed	Ezrin and moesin function together to promote T cell activation.	EZR MSN	5.59e-06	3	48	2	19124745
Pubmed	Role of GTP binding, isoprenylation, and the C-terminal α-helices in the inhibition of cell spreading by the interferon-induced GTPase, mouse guanylate-binding protein-2.	GBP1 GBP2	5.59e-06	3	48	2	20950129
Pubmed	Two families of GTPases dominate the complex cellular response to IFN-gamma.	GBP1 GBP2	5.59e-06	3	48	2	9862701
Pubmed	Arginylation regulates purine nucleotide biosynthesis by enhancing the activity of phosphoribosyl pyrophosphate synthase.	PRPS2 PRPS1	5.59e-06	3	48	2	26175007
Pubmed	Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus.	EZR MSN	1.12e-05	4	48	2	17237445
Pubmed	The ERM proteins interact with the HOPS complex to regulate the maturation of endosomes.	EZR MSN	1.12e-05	4	48	2	21148287
Pubmed	ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.	ATAD3B ATAD3C	1.12e-05	4	48	2	35236834
Pubmed	Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.	ATAD3B ATAD3C	1.12e-05	4	48	2	36736924
Pubmed	Rho-ROCK-dependent ezrin-radixin-moesin phosphorylation regulates Fas-mediated apoptosis in Jurkat cells.	EZR MSN	1.12e-05	4	48	2	18941185
Pubmed	Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family.	EZR MSN	1.12e-05	4	48	2	9314537
Pubmed	Mutagenesis of the ezrin-radixin-moesin binding domain of L-selectin tail affects shedding, microvillar positioning, and leukocyte tethering.	EZR MSN	1.12e-05	4	48	2	15178693
Pubmed	Functional binding interaction identified between the axonal CAM L1 and members of the ERM family.	EZR MSN	1.12e-05	4	48	2	12070130
Pubmed	CPI-17 drives oncogenic Ras signaling in human melanomas via Ezrin-Radixin-Moesin family proteins.	EZR MSN	1.12e-05	4	48	2	27793041
Pubmed	The NHE1 Na+/H+ exchanger recruits ezrin/radixin/moesin proteins to regulate Akt-dependent cell survival.	EZR MSN	1.12e-05	4	48	2	15096511
Pubmed	Genomic organization and chromosomal localization of a new member of the murine interferon-induced guanylate-binding protein family.	GBP1 GBP2	1.12e-05	4	48	2	10386861
Pubmed	Cortical mechanics and meiosis II completion in mammalian oocytes are mediated by myosin-II and Ezrin-Radixin-Moesin (ERM) proteins.	EZR MSN	1.12e-05	4	48	2	20660156
Pubmed	In Vitro and in Vivo Characterization of Molecular Interactions between Calmodulin, Ezrin/Radixin/Moesin, and L-selectin.	EZR MSN	1.12e-05	4	48	2	19129194
Pubmed	Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death.	EZR MSN	1.12e-05	4	48	2	15818415
Interaction	EIF5AL1 interactions	EZR EML5 MSN	1.89e-05	22	48	3	int:EIF5AL1
Interaction	DKK3 interactions	ASPM TTF2 ATAD3B ATAD3C	3.04e-05	75	48	4	int:DKK3
Cytoband	1p22	TTF2 MCOLN2	2.01e-04	20	48	2	1p22
Cytoband	1p22.2	GBP1 GBP2	3.98e-04	28	48	2	1p22.2
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	GBP1 GBP2 MCOLN2	4.08e-04	137	48	3	chr1p22
Cytoband	1p36.33	ATAD3B ATAD3C	2.98e-03	77	48	2	1p36.33
Cytoband	7q11.23	PMS2P2 PMS2P5	4.68e-03	97	48	2	7q11.23
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	PLEKHF2 PLEKHF1	1.37e-03	31	32	2	81
GeneFamily	Nuclear hormone receptors	NR6A1 NR5A2	3.39e-03	49	32	2	71
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	EZR MSN	3.53e-03	50	32	2	1293
GeneFamily	AAA ATPases	ATAD3B ATAD3C	3.95e-03	53	32	2	413
GeneFamily	WD repeat domain containing	DCAF11 EML5 EML6	1.09e-02	262	32	3	362
GeneFamily	Actins\|Deafness associated genes	LOXHD1 PRPS1	1.70e-02	113	32	2	1152
Coexpression	MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN	ZNF438 DENND5B GBP1 GBP2 RNF217 PLEKHF2 PLEKHF1	8.25e-06	403	48	7	MM1029
CoexpressionAtlas	dev gonad_e13.5_F_MeioticGermCell_Oct_top-relative-expression-ranked_200	DOCK3 TRANK1 NR6A1 EML5 UTF1	1.58e-05	143	47	5	gudmap_dev gonad_e13.5_F_MeioticGermCell_Oct_200
CoexpressionAtlas	FacebaseRNAseq_e8.5_Floor Plate_top-relative-expression-ranked_1000	ASPM GLIS3 DENND5B EZR TTF2 NR6A1 EML5 ARHGEF1 EML6 PRPS1	5.15e-05	994	47	10	Facebase_RNAseq_e8.5_Floor Plate_1000
ToppCell	facs-Heart-Unknown-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GBP1 TRANK1 VSTM5 FOXA3	1.53e-05	142	47	4	759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ASPM ATAD3C ARHGEF1 MCOLN2	2.44e-05	160	47	4	1a9329d8183296f36928bd9e96f10db9f04ce326
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTS18 GBP2 DCAF11 EML6	2.88e-05	167	47	4	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|343B / Donor, Lineage, Cell class and subclass (all cells)	TTF2 NR6A1 AOC1 MCOLN2	3.02e-05	169	47	4	2098f15a388d019ed7f1d4c209affd5ca2886dcc
ToppCell	control-dn_T\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ASPM EZR GBP1 GBP2	3.09e-05	170	47	4	839f62860b4a52d06e6a8fce7632195c7310b89d
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DENND5B TTF2 EML6 NR5A2	3.39e-05	174	47	4	6c36d607c48267a75ab4da6fb2fe3f931d1b3b52
ToppCell	10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GBP2 DCAF11 ATAD3C PLEKHF1	3.86e-05	180	47	4	27672ac6a02172a31851f18decb9acffa8f5a703
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMER3 EML5 FOXA3 PTPRN	3.86e-05	180	47	4	d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	DENND5B EZR PLEKHF2 EML6	4.48e-05	187	47	4	43f81863063509337bd56a67010c62fb51109bd5
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	DENND5B EZR PLEKHF2 EML6	4.48e-05	187	47	4	ea56cfca919a09db852b7ee5e42323f822962465
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_memory\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	DENND5B EZR PLEKHF2 EML6	4.58e-05	188	47	4	b6ae707b033a17c75ca81f9194631ead1b63d170
ToppCell	control-B_memory\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B EZR PLEKHF2 EML6	4.97e-05	192	47	4	d6ef271b6c4f9b49323650f3f773abd61c1b13c3
ToppCell	healthy_donor-Lymphocytic-B_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	DENND5B EZR PLEKHF2 EML6	4.97e-05	192	47	4	7d9e5772b6e531b50ed4e4d6304ef11235f27f37
ToppCell	healthy_donor-Lymphocytic-B_cell-\|healthy_donor / Disease condition, Lineage, Cell class and subclass	DENND5B EZR PLEKHF2 EML6	4.97e-05	192	47	4	975312f9d6cede4d4f5b737e481e5c73accc8c50
ToppCell	BLOOD--(1)_T_cell-(1)_Activated_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ASPM EZR GBP1 GBP2	5.17e-05	194	47	4	6a0cbb9d5c5c4effb02dff654c6c3b184026875c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PSME4 PLEKHF1 MCOLN2 MSN	5.17e-05	194	47	4	24837a27b0041fe8c348225fa8b09b127d743603
ToppCell	BLOOD--(1)_Activated_T_cells\| / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	ASPM EZR GBP1 GBP2	5.27e-05	195	47	4	45515d5da8a8c8242eb70a1bea24fe44eca5407b
ToppCell	Mild-CD8+_T_activated\|World / Disease group and Cell class	GBP1 TRANK1 ARHGEF1 MCOLN2	5.38e-05	196	47	4	79632190e44fcef9d7c11d9b9e37f2ebf0e6e255
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_1\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTF2 AOC1 UTF1 MCOLN2	5.49e-05	197	47	4	5bd2f32137fd849931e52093d630d2e7e27daf4f
ToppCell	medial-Hematologic-Myeloid_Dendritic_Type_1-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTF2 AOC1 UTF1 MCOLN2	5.49e-05	197	47	4	d9baa0be469fd8737a74b5078d30ce7d66759160
ToppCell	medial-2-Hematologic-Myeloid_Dendritic_Type_1\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TTF2 AOC1 UTF1 MCOLN2	5.49e-05	197	47	4	3c1147857de6a7ab6b0cf77f5a6364d4c8669693
ToppCell	Mild-CD8+_T_activated\|Mild / Disease group and Cell class	GBP1 GBP2 TRANK1 MCOLN2	5.60e-05	198	47	4	ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell	Control-Control-Lymphocyte-B-B_memory\|Control / Disease, condition lineage and cell class	DENND5B EZR PLEKHF2 EML6	5.71e-05	199	47	4	76976d5f79f324a6c488161847c50f207361d6c6
ToppCell	mild-B_memory\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B EZR EML6 MCOLN2	5.71e-05	199	47	4	e6ac9a0959b0de2c6a99298feb7715aa80ade1dd
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-B-B_memory\|COVID-19_Convalescent / Disease, condition lineage and cell class	DENND5B EZR PLEKHF2 EML6	5.71e-05	199	47	4	5bbda86486910d053ca51b9caee487d78f6462cb
ToppCell	Tracheal-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Duct\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	GLIS3 EZR NR6A1 SLC5A1	5.71e-05	199	47	4	527aae1d9d37a50deefc01fc0c064a53673681bd
ToppCell	mild-B_intermediate\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B EZR EML6 MCOLN2	5.82e-05	200	47	4	8e3132a1fe3708f725c5c4077878fb87bbea3678
ToppCell	mild-B_intermediate\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DENND5B EZR EML6 MCOLN2	5.82e-05	200	47	4	fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell	Thalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.Cacng4_(Non-anterior_nuclei)\|Thalamus / BrainAtlas - Mouse McCarroll V32	LOXHD1 DCST1 SLC5A1	7.12e-05	76	47	3	4afc8d0e79870c635a89dd8e7ca91ebfe482b4ab
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)-\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RTP3 MCOLN2 NR5A2	1.06e-04	87	47	3	cc89f4176b70d4eb5b5bf0ff2319b5f1f9e292c0
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RTP3 MCOLN2 NR5A2	1.06e-04	87	47	3	4274e04fa4aca85c2cefd8c5e03d0fa4a4f15536
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RTP3 MCOLN2 NR5A2	1.06e-04	87	47	3	54cbdf80aae3595eaace20c7cbac763282558213
ToppCell	Posterior_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Vwf_(Vwf)--\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	RTP3 MCOLN2 NR5A2	1.06e-04	87	47	3	8b1a0bd5d6af32afaca19e9c69f86530bbaa309d
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-endothelial_cells_B\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	VSTM5 FOXA3 RNF217	2.96e-04	123	47	3	e0130010aa406d4e9d8f16ad32858c382277eeb2
ToppCell	Control-Mast_cells-Dendritic_cells\|Control / group, cell type (main and fine annotations)	PRPS2 LOXHD1 PLEKHF1	4.06e-04	137	47	3	9906225a2eb1a891e5bfbb00929bc041f325b376
ToppCell	facs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GBP1 TRANK1 FOXA3	4.42e-04	141	47	3	4aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCell	facs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GBP1 TRANK1 FOXA3	4.42e-04	141	47	3	e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCell	TCGA-Adrenal\|World / Sample_Type by Project: Shred V9	EML5 PTPRN EML6	4.79e-04	145	47	3	522ad2bc90b8ec326fcbc7b2250b09566efeeca2
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma-3\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	AOC1 FOXA3 NR5A2	4.89e-04	146	47	3	e55b4acecf4e363b5afa287c747c2e58c4597f3a
ToppCell	TCGA-Head_and_Esophagus-Primary_Tumor-Esophageal_Carcinoma-Adenocarcinoma\|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9	AOC1 FOXA3 NR5A2	5.19e-04	149	47	3	92a8931a51db619fb5f0638d319c02e7838f6559
ToppCell	MS-CD4-antiviral_CD4\|MS / Condition, Cell_class and T cell subcluster	GBP1 GBP2 NR5A2	5.50e-04	152	47	3	b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma-7\|TCGA-Cervix / Sample_Type by Project: Shred V9	AOC1 FOXA3 SLC5A1	6.27e-04	159	47	3	75a82bbabd97b168dbf1c3f43a9bdad48ce18c78
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK3 PTPRN EML6	6.27e-04	159	47	3	7747cef94c55144fddcd024a7495318357f1351b
ToppCell	Adult-Immune-mast_cell-D175\|Adult / Lineage, Cell type, age group and donor	TRMT1 TOMM20 TRANK1	6.27e-04	159	47	3	9f53fe2e0f25448d62a591c8e528e9a49b5400d5
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|368C / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 NR6A1 MCOLN2	6.38e-04	160	47	3	bcd90ef96464bd901b87b94c696de70c113bfd03
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	AOC1 UTF1 MCOLN2	6.50e-04	161	47	3	1d446f5ba57d84949823a35cbedaee8f448fe40f
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRPS2 UTF1 MCOLN2	6.50e-04	161	47	3	249c2b97cc25de5053f5048ee354615df49b2081
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	AOC1 UTF1 MCOLN2	6.50e-04	161	47	3	1670108afc0af90861eb80a84e59995571c0da1b
ToppCell	PCW_13-14-Neuronal-Neuronal_postreplicative-neuro_immature_neuronal_(2)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	AMER3 EML5 PTPRN	6.50e-04	161	47	3	bb9cb42882aaa4a1ecf9b480c0e7ac302f2c0d5d
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	METTL18 MCOLN2 PRPS1	6.50e-04	161	47	3	d72c572613f8eff3251cb7b1e9dcc76d193b2f21
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo-Endo_Ctla2a\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GBP2 RTP3 MSN	6.50e-04	161	47	3	a60ef3f390f56bb05b687b17986fe6382f69f260
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell-Endo\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GBP2 RTP3 MSN	6.61e-04	162	47	3	0bdb1e5ba33e162bec1acb28256c1405a7658ee5
ToppCell	3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-DZ_GC_cell\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EZR PLEKHF2 EML6	6.61e-04	162	47	3	3e15b3e97a2ade86d0cb0ab15fccb9a2e2e27dd4
ToppCell	primary_visual_cortex-Non-neuronal-endothelial_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	GBP2 RTP3 MSN	6.61e-04	162	47	3	5799a602ef8d83925907e8e34532428be7330228
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ASPM PRPS2 ARHGEF1	6.85e-04	164	47	3	249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCell	368C-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	DOCK3 NR6A1 MCOLN2	6.85e-04	164	47	3	67c636a2cc32e56c6186dc7e779cc19af04639d2
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	ASPM TTF2 ATAD3C	6.85e-04	164	47	3	0662cd9d21608efacc336e0a582859f3b9a4951d
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	NR6A1 AOC1 MCOLN2	6.85e-04	164	47	3	eae6d440877b292ad18dc4bd02802dda5b2f9c60
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-B_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PRPS2 UTF1 MCOLN2	6.98e-04	165	47	3	22293c6b55f44636440cd737efb786ff5de3373d
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-CD1c-positive_myeloid_dendritic_cell-DC2_(CD1c+_dendritic_cell)-DC2_L.1.2.1.3\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ZNF586 RNF217 NR5A2	6.98e-04	165	47	3	76abebe80e5f8bf44825bb619ae86fcb6f66ffeb
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-ventral_progenitors_and_neurons_1\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	AMER3 VSTM5 PTPRN	6.98e-04	165	47	3	9795ce31689bc63f5a2d68725ef00b23a90c3846
ToppCell	healthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast\|healthy_donor / Disease condition, Lineage, Cell class and subclass	ASPM DENND5B EML6	7.10e-04	166	47	3	2b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VSTM5 FOXA3 SLC5A1	7.22e-04	167	47	3	31633899aae852873a4887e72c621474b0a51a33
ToppCell	TCGA-Bile_Duct-Primary_Tumor-Cholangiocarcinoma-Intrahepatic-2\|TCGA-Bile_Duct / Sample_Type by Project: Shred V9	TOMM20 ZNF496 METTL18	7.35e-04	168	47	3	c70bf73bb800e4722cedc35bbc17ea3113d1012d
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	NR6A1 AOC1 EML6	7.48e-04	169	47	3	e68e6c24606fd46eca6f86bb63fa86ea17879ae2
ToppCell	facs-Lung-EPCAM-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTP3 NR6A1 PLEKHF2	7.61e-04	170	47	3	12203d4410f38cc933d9f160b5fb76828df94119
ToppCell	facs-Lung-EPCAM-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RTP3 NR6A1 PLEKHF2	7.61e-04	170	47	3	f9decb3bf3bf6d4996b0ac27af768236e116aac5
ToppCell	ILEUM-non-inflamed-(3)_mature_DC\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	GBP1 NR6A1 AOC1	7.61e-04	170	47	3	60151394460e6f27a42fab434e8b7b2adc78b128
ToppCell	E16.5-samps-Epithelial-Alveolar_epithelial_precursor-Uncommitted_AE_cell\|E16.5-samps / Age Group, Lineage, Cell class and subclass	EZR VSTM5 FOXA3	7.61e-04	170	47	3	5a64e05c263df915085988d881808221e2c0f2e2
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4/8-lo\|Lung / Manually curated celltypes from each tissue	ASPM AMER3 MCOLN2	7.74e-04	171	47	3	dfd4a15ab68ef5a9a1954b1b1540ae04017885a6
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|Endothelial_cells / Location, Cell class and cell subclass	EZR PTPRN UTF1	7.74e-04	171	47	3	dcb6c41980008d0b9eeb54999faff77311554976
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GBP1 TTF2 GBP2	7.74e-04	171	47	3	2b7c5a557c4bc5c573211c4d618bdd6766a24916
ToppCell	E12.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte\|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	EZR FOXA3 AFM	7.74e-04	171	47	3	a4d6b0f57eead11b01153688b06b2a45a3b488f2
ToppCell	367C-Myeloid-Dendritic-cDC_proliferating_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ASPM TTF2 ATAD3C	7.74e-04	171	47	3	0eea035fde32cc2a75a0d4227911edb5d54ed47e
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	GBP1 TTF2 GBP2	7.74e-04	171	47	3	dcb15bc54aeea06ef8f07f1134f3ff1e21ac0e4f
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VSTM5 FOXA3 SLC5A1	8.00e-04	173	47	3	e8afef5ae68983eb8d6515b43952636a47e9d3d4
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	AOC1 FOXA3 SLC5A1	8.00e-04	173	47	3	e4d9a9a781acc531bc81c3fcee24d637e805c8e1
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	VSTM5 FOXA3 SLC5A1	8.00e-04	173	47	3	3aa1d28d4814798a772808ed29e1dbbdf92abd03
ToppCell	Dendritic_Cells-Donor_07\|World / lung cells shred on cell class, cell subclass, sample id	AOC1 UTF1 MCOLN2	8.00e-04	173	47	3	ddb900ef4abeabe2e59db1009efc337e35d301fe
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLIS3 AMER3 PTPRN	8.13e-04	174	47	3	9f114e61458659005b6d0b4aa30a7a059e7aa5c6
ToppCell	10x3'2.3-week_17-19-Lymphocytic_T-T_NK-Treg\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	GBP1 GBP2 PLEKHF1	8.13e-04	174	47	3	7ca39c9ecd609e5ade30dac1a948a4a4fff1b3b2
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLIS3 AMER3 PTPRN	8.13e-04	174	47	3	a62531ebf16b32b249168dca11b870f63a8aa81c
ToppCell	5'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GLIS3 AMER3 PTPRN	8.27e-04	175	47	3	182e45f5c02214d6b9f317ff5dc43af8b42de978
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_neuroendocrine1[NE1]_(11)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	AMER3 PTPRN UTF1	8.27e-04	175	47	3	9941c35601134d88d1b3249c81f8b43a8fc61610
ToppCell	Healthy_donor-Plasmablast\|World / disease group, cell group and cell class (v2)	ASPM DENND5B ATAD3C	8.27e-04	175	47	3	5293e00fda63a291aa393bdf82ebd4b80265049f
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ASPM DENND5B EML6	8.27e-04	175	47	3	3b5346fba617292de71963b6175e85a4f182fe30
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Zbtb32+_B\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DENND5B EZR MCOLN2	8.41e-04	176	47	3	741fdacb33d49b030a797a6099fdea0949a22e75
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMER3 FOXA3 PTPRN	8.41e-04	176	47	3	71f96cace3f20fbef975037f4deff9b82b0282a1
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_B-plasmablast\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	ASPM DENND5B EML6	8.41e-04	176	47	3	dc4e939a07bad21ab36181f9588df3fa662f9a92
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ASPM DENND5B EML6	8.55e-04	177	47	3	4c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ASPM DENND5B EML6	8.55e-04	177	47	3	fc40918825b7e1eb6861df59dfca944778a64b98
ToppCell	Healthy-Plasmablast\|Healthy / disease group, cell group and cell class	ASPM DENND5B EML6	8.55e-04	177	47	3	4ff75c609ac9edf7a94bda42eb7124c559e8b6aa
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AFM SLC5A1 MCOLN2	8.55e-04	177	47	3	2f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCell	metastatic_Brain-Myeloid_cells-Activated_DCs\|metastatic_Brain / Location, Cell class and cell subclass	ZNF438 NR6A1 AOC1	8.55e-04	177	47	3	739496fcc4156f4d5e3de9cd21cf3856037f0678
ToppCell	PBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	ASPM DENND5B EML6	8.55e-04	177	47	3	d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCell	facs-Marrow-KLS-24m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTF2 VSTM5 PRPS1	8.83e-04	179	47	3	5297f7459b40ca780a1983fecc1bb9c035c7677e
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	GBP1 GBP2 TRANK1	8.83e-04	179	47	3	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-CD8_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	GBP1 GBP2 PLEKHF1	8.83e-04	179	47	3	4e9e0deabf9b09ffcf30fed6d5eae72ce0ef2f1f
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMER3 ATAD3C PTPRN	8.83e-04	179	47	3	f93e81a3fd94adedb24a9db4ac1d53e275bbf8b5
ToppCell	3'-Adult-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AMER3 ATAD3C PTPRN	8.83e-04	179	47	3	878b15ea62e3405682a538f79f58d74b9cd3f398
Disease	neuromuscular disease (implicated_via_orthology)	ATAD3B ATAD3C	1.30e-05	4	44	2	DOID:440 (implicated_via_orthology)
Disease	syndrome (implicated_via_orthology)	ATAD3B ATAD3C	3.27e-04	18	44	2	DOID:225 (implicated_via_orthology)
Disease	treatment-resistant hypertension	DOCK3 FOXA3 EML6	5.82e-04	109	44	3	EFO_1002006
Disease	response to calcium channel blocker	DOCK3 FOXA3	3.18e-03	56	44	2	EFO_0007767
Disease	Liver Cirrhosis, Experimental	EZR GBP2 RTP3 AFM MSN	5.72e-03	774	44	5	C0023893
Disease	nicotine dependence	GLIS3 NR5A2	6.07e-03	78	44	2	EFO_0003768
Disease	carpal tunnel syndrome	ZNF438 AOC1	7.84e-03	89	44	2	EFO_0004143
Disease	eye color	TRANK1 AFM	8.01e-03	90	44	2	EFO_0003949
Disease	Degenerative polyarthritis	EZR MSN	8.53e-03	93	44	2	C0029408
Disease	Osteoarthrosis Deformans	EZR MSN	8.53e-03	93	44	2	C0086743

Protein segments in the cluster

Peptide	Gene	Start	Entry
PKKCFRNLFHIRRNK	AMER3	156	Q8N944
LKAKQRKDPRFCAFV	ARHGEF1	526	Q92888
KVDAQRRLCFFYNKK	AFM	116	P43652
AFRFKRKLPKYLLFT	AOC1	566	P19801
KRFRCFQAQKLYKRR	ASPM	1496	Q8IZT6
RRLQKQHFCGRRKKY	ADAMTS18	246	Q8TE60
SPQERKKRDCYFEFR	FAM166C	186	A6NJV1
PLLDFRRKVNKCYRG	PTPRN	886	Q16849
FNCDCLIPLKRKRKY	LOXHD1	1911	Q8IVV2
RKPEKLKTLFCYFRR	PARG	671	Q86W56
CRYGRFRKFKSIKAR	DCAF11	201	Q8TEB1
EFQRNIKKKRACFPF	PMS2P5	66	A8MQ11
RCRKPKVTQLYKCRF	METTL18	251	O95568
RKESPLLFKFRAKFY	MSN	71	P26038
IRKFFPKKKCFVFDR	GBP1	226	P32455
RLCIRKFFPKRKCFV	GBP2	221	P32456
NIKKKRACFPFAFCR	PMS2P1	376	A4D2B8
GRKFPFFLRNKEYVC	DOCK3	1361	Q8IZD9
RVIAAFYFPKREKKR	DCST1	576	Q5T197
CPRRYKPFNARYKLL	GLIS3	386	Q8NEA6
PLTKKLYKRYAFLRC	DENND5B	891	Q6ZUT9
KRRLKLAQFDYGRKC	ATAD3C	326	Q5T2N8
RYPCLRKGAKFRKYI	EML5	546	Q05BV3
KFPCLKRGAKFRKYV	EML6	546	Q6ZMW3
RKENPLQFKFRAKFY	EZR	71	P15311
RFLNFFLEKYKRPVC	MCOLN2	321	Q8IZK6
CRKKPKARQFFLFND	PLEKHF2	46	Q9H8W4
DKTQRKRCPYCRFQK	NR5A2	131	O00482
KGFFKRSICNKRVYR	NR6A1	81	Q15406
CRKKAKPRIFFLFND	PLEKHF1	46	Q96S99
KNLVFRILKKCYRGR	RTP3	116	Q9BQQ7
QRAARLKTFPCKRFK	TRMT1	596	Q9NXH9
RNIKKKRACFPFAFC	PMS2P2	36	O95744
NIKKKRACFPFAFCR	PMS2P2	241	O95744
FENGCYLRRQKRFKL	FOXA3	201	P55318
FVFPIYCLCKKQRKR	RNF217	521	Q8TC41
KRRLKLAQFDYGRKC	ATAD3B	501	Q5T9A4
RPYECGEYRKLFKNK	ZNF586	86	Q9NXT0
NKCAYKFQRKRRHKL	VSTM5	171	A8MXK1
CFPYARQDKKDKSRA	PRPS2	91	P11908
RKGKDKFNPRRFCLF	PSME4	1331	Q14997
KFNPRRFCLFKGIFR	PSME4	1336	Q14997
LKDKARPFQCRYCVK	ZNF496	546	Q96IT1
CFPYARQDKKDKSRA	PRPS1	91	P60891
EEVYKKLGRKRCPNF	TRANK1	1326	O15050
EKKKGIFRRAYDLFC	SLC5A1	596	P13866
FQGKRRKYIINKCRD	ZNF438	396	Q7Z4V0
CIYFDRKRRSDPNFK	TOMM20	21	Q15388
PQDKKEYRLFFRCIR	TTF2	66	Q9UNY4
PAQCRRRYKFLKDKF	UTF1	111	Q5T230
RFFRFCVAIKKENYP	VPS13D	3141	Q5THJ4