Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	1.00e-06	1244	36	12	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	1.26e-06	1271	36	12	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	3.78e-06	1412	36	12	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	5.31e-06	1459	36	12	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	2.57e-04	320	36	5	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	2.80e-04	326	36	5	GO:0001217
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD1 RGPD2	5.88e-04	20	36	2	GO:0061665
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD1 RGPD2	1.92e-03	36	36	2	GO:0019789
GeneOntologyMolecularFunction	GTPase regulator activity	RGPD1 ARHGEF38 RGPD2 ARHGEF40 ARHGAP12	2.04e-03	507	36	5	GO:0030695
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RGPD1 ARHGEF38 RGPD2 ARHGEF40 ARHGAP12	2.04e-03	507	36	5	GO:0060589
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	3.13e-03	560	36	5	GO:0001228
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	3.28e-03	566	36	5	GO:0001216
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RGPD1 RGPD2	3.67e-03	50	36	2	GO:0003755
GeneOntologyMolecularFunction	cis-trans isomerase activity	RGPD1 RGPD2	4.11e-03	53	36	2	GO:0016859
GeneOntologyBiologicalProcess	transposable element silencing	ZNF729 ZNF91 ZNF493 ZNF99	1.08e-06	46	35	4	GO:0010526
GeneOntologyBiologicalProcess	retrotransposition	ZNF729 ZNF91 ZNF493 ZNF99	1.28e-06	48	35	4	GO:0032197
GeneOntologyBiologicalProcess	transposition	ZNF729 ZNF91 ZNF493 ZNF99	1.51e-06	50	35	4	GO:0032196
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD1 RGPD2	1.00e-04	9	35	2	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD1 RGPD2	1.25e-04	10	35	2	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD1 RGPD2	2.16e-04	13	35	2	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD1 RGPD2	2.51e-04	14	35	2	GO:1903299
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD1 RGPD2	7.58e-05	8	35	2	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD1 RGPD2	1.22e-04	10	35	2	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD1 RGPD2	2.45e-04	14	35	2	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD1 RGPD2	4.10e-04	18	35	2	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD1 RGPD2	5.08e-04	20	35	2	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD1 RGPD2	5.61e-04	21	35	2	GO:0106068
MousePheno	decreased eosinophil cell number	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	1.04e-06	84	31	5	MP:0005012
MousePheno	decreased granulocyte number	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	2.20e-04	254	31	5	MP:0000334
MousePheno	abnormal eosinophil cell number	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	2.24e-04	255	31	5	MP:0002602
MousePheno	abnormal eosinophil morphology	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	2.45e-04	260	31	5	MP:0005061
MousePheno	aneuploidy	RGPD1 RGPD2 DDX11L8	3.26e-04	61	31	3	MP:0004024
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD1 RGPD2	5.60e-04	16	31	2	MP:0003701
Domain	zf-C2H2_6	ZNF729 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681	1.03e-10	314	33	10	PF13912
Domain	Znf_C2H2-like	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 TRAFD1 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	3.61e-10	796	33	13	IPR015880
Domain	KRAB	ZNF729 ZNF708 ZNF320 ZNF676 ZNF91 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	3.69e-10	358	33	10	PS50805
Domain	Znf_C2H2	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 TRAFD1 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	4.15e-10	805	33	13	IPR007087
Domain	ZnF_C2H2	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 TRAFD1 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	4.34e-10	808	33	13	SM00355
Domain	KRAB	ZNF729 ZNF708 ZNF320 ZNF676 ZNF91 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	4.96e-10	369	33	10	SM00349
Domain	KRAB	ZNF729 ZNF708 ZNF320 ZNF676 ZNF91 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	5.09e-10	370	33	10	IPR001909
Domain	-	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	8.52e-10	679	33	12	3.30.160.60
Domain	zf-C2H2	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	1.07e-09	693	33	12	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	1.09e-09	694	33	12	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	3.80e-09	775	33	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	3.92e-09	777	33	12	PS00028
Domain	KRAB	ZNF729 ZNF708 ZNF320 ZNF91 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	8.12e-09	358	33	9	PF01352
Domain	GCC2_Rab_bind	RGPD1 RGPD2	6.32e-05	7	33	2	IPR032023
Domain	Rab_bind	RGPD1 RGPD2	6.32e-05	7	33	2	PF16704
Domain	-	RGPD1 RGPD2	1.35e-04	10	33	2	1.10.220.60
Domain	GRIP	RGPD1 RGPD2	1.65e-04	11	33	2	PF01465
Domain	Grip	RGPD1 RGPD2	1.65e-04	11	33	2	SM00755
Domain	Ran_BP1	RGPD1 RGPD2	1.98e-04	12	33	2	PF00638
Domain	GRIP_dom	RGPD1 RGPD2	1.98e-04	12	33	2	IPR000237
Domain	GRIP	RGPD1 RGPD2	1.98e-04	12	33	2	PS50913
Domain	RANBD1	RGPD1 RGPD2	1.98e-04	12	33	2	PS50196
Domain	RanBD	RGPD1 RGPD2	2.33e-04	13	33	2	SM00160
Domain	Ran_bind_dom	RGPD1 RGPD2	2.33e-04	13	33	2	IPR000156
Domain	-	RGPD1 RGPD2 ARHGEF40 ARHGAP12	4.79e-03	391	33	4	2.30.29.30
Domain	DH_1	ARHGEF38 ARHGEF40	5.53e-03	63	33	2	PS00741
Domain	-	RGPD1 ADCY10 RGPD2	5.73e-03	207	33	3	1.25.40.10
Domain	PH_dom-like	RGPD1 RGPD2 ARHGEF40 ARHGAP12	6.47e-03	426	33	4	IPR011993
Domain	DH_2	ARHGEF38 ARHGEF40	6.78e-03	70	33	2	PS50010
Domain	RhoGEF	ARHGEF38 ARHGEF40	6.78e-03	70	33	2	PF00621
Domain	DH-domain	ARHGEF38 ARHGEF40	6.97e-03	71	33	2	IPR000219
Domain	-	ARHGEF38 ARHGEF40	6.97e-03	71	33	2	1.20.900.10
Domain	TPR-like_helical_dom	RGPD1 ADCY10 RGPD2	7.94e-03	233	33	3	IPR011990
Domain	SH3_9	ARHGEF38 ARHGAP12	8.36e-03	78	33	2	PF14604
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF729 RGPD1 RGPD2 ZNF91 ZNF493 ZNF99 ZNF569 ZNF681 ZNF254	1.42e-04	1022	29	9	MM15436
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF729 ZNF708 ZNF320 ZNF676 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	2.86e-04	1387	29	10	M734
Pathway	BIOCARTA_RANBP2_PATHWAY	RGPD1 RGPD2	6.13e-04	18	29	2	MM1549
Pathway	REACTOME_GLUCOSE_METABOLISM	RGPD1 RGPD2 ALDOB	6.21e-04	82	29	3	MM15394
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF729 ZNF91 ZNF493 ZNF99 ZNF569 ZNF681 ZNF254	7.53e-04	768	29	7	MM14851
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF91 ZNF493 ZNF626 ZNF99 ZNF681 ZNF254	1.05e-15	29	36	7	14563677
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681 ZNF254	3.94e-15	15	36	6	15885501
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF91 ZNF493 ZNF99 ZNF569 ZNF681	1.07e-11	49	36	6	9630514
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF91 ZNF493 ZNF99	2.02e-10	10	36	4	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF91 ZNF493 ZNF99	3.17e-10	11	36	4	15469996
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF708 ZNF320 ZNF91 ZNF493 ZNF626 ZNF569 ZNF681	6.76e-10	181	36	7	37372979
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF91 ZNF493 ZNF99	6.86e-10	13	36	4	19850934
Pubmed	Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia.	ZNF569 ZNF681 ZNF254	1.15e-06	20	36	3	2542606
Pubmed	Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea.	ZNF569 ZNF681 ZNF254	1.15e-06	20	36	3	7479878
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 ZBTB41 ZNF91 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	1.39e-06	808	36	8	20412781
Pubmed	A lethal deletion on mouse chromosome 7 affects regulation of liver-cell-specific functions: posttranscriptional control of serum protein and transcriptional control of aldolase B synthesis.	ALDOB AFP	6.24e-06	4	36	2	3857594
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD1 RGPD2	2.18e-05	7	36	2	7559465
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD1 RGPD2	2.18e-05	7	36	2	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD1 RGPD2	2.18e-05	7	36	2	38838144
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD1 RGPD2	2.18e-05	7	36	2	15710750
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD1 RGPD2	2.18e-05	7	36	2	21205196
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD1 RGPD2	2.18e-05	7	36	2	26632511
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD1 RGPD2	2.18e-05	7	36	2	17372272
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD1 RGPD2	2.18e-05	7	36	2	24403063
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD1 RGPD2	2.18e-05	7	36	2	18949001
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD1 RGPD2	2.18e-05	7	36	2	23818861
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD1 RGPD2	2.18e-05	7	36	2	38657106
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD1 RGPD2	2.18e-05	7	36	2	11353387
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD1 RGPD2	2.18e-05	7	36	2	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD1 RGPD2	2.18e-05	7	36	2	9037092
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD1 RGPD2	2.18e-05	7	36	2	23536549
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD1 RGPD2	2.18e-05	7	36	2	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD1 RGPD2	2.18e-05	7	36	2	22821000
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD1 RGPD2	2.18e-05	7	36	2	8603673
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD1 RGPD2	2.18e-05	7	36	2	20682751
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD1 RGPD2	2.91e-05	8	36	2	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD1 RGPD2	2.91e-05	8	36	2	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD1 RGPD2	2.91e-05	8	36	2	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD1 RGPD2	2.91e-05	8	36	2	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD1 RGPD2	2.91e-05	8	36	2	21310149
Pubmed	Chromosomal location of fifteen unique mouse KRAB-containing zinc finger loci.	ZNF569 ZNF681 ZNF254	3.52e-05	61	36	3	8662221
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD1 RGPD2	3.73e-05	9	36	2	18394993
Pubmed	Comparative analysis of KRAB zinc finger proteins in rodents and man: evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes.	ZNF681 ZNF254	3.73e-05	9	36	2	10360839
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD1 RGPD2	3.73e-05	9	36	2	28877029
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD1 RGPD2	3.73e-05	9	36	2	11553612
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD1 RGPD2	3.73e-05	9	36	2	9733766
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD1 RGPD2	3.73e-05	9	36	2	17887960
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD1 RGPD2	3.73e-05	9	36	2	10601307
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD1 RGPD2	3.73e-05	9	36	2	28100513
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD1 RGPD2	4.66e-05	10	36	2	16332688
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD1 RGPD2	4.66e-05	10	36	2	27160050
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD1 RGPD2	4.66e-05	10	36	2	8857542
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD1 RGPD2	4.66e-05	10	36	2	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD1 RGPD2	5.70e-05	11	36	2	35771867
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD1 RGPD2	5.70e-05	11	36	2	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD1 RGPD2	5.70e-05	11	36	2	34110283
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD1 RGPD2	8.07e-05	13	36	2	31427429
Pubmed	Limited expression of nuclear pore membrane glycoprotein 210 in cell lines and tissues suggests cell-type specific nuclear pores in metazoans.	RGPD1 RGPD2	1.08e-04	15	36	2	14697343
Pubmed	Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells.	ZNF91 ZNF99	1.24e-04	16	36	2	8467795
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	RGPD1 RGPD2	2.38e-04	22	36	2	27717094
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD1 RGPD2 ZBTB41 PALB2 NARS2 ARHGAP12 CCDC148	6.02e-04	1442	36	7	35575683
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	RGPD1 RGPD2	7.15e-04	38	36	2	12791264
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD1 RGPD2 DNAJC13 PALB2	8.94e-04	418	36	4	34709266
Pubmed	Dominant and redundant functions of TFIID involved in the regulation of hepatic genes.	ALDOB AFP	9.16e-04	43	36	2	18722179
Cytoband	19p12	ZNF729 ZNF708 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF681 ZNF254	2.55e-17	90	36	9	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF708 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF681 ZNF254	4.34e-16	122	36	9	chr19p12
Cytoband	2p11.2	RGPD1 RGPD2	1.17e-03	64	36	2	2p11.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q24	PLA2R1 CCDC148	4.50e-03	127	36	2	chr2q24
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF708 ZBTB41 ZNF320 ZNF676 ZNF91 ZNF493 ZNF626 ZNF99 ZNF569 ZNF681 ZNF254	2.38e-10	718	28	12	28
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ARHGEF38 ARHGEF40	4.67e-03	66	28	2	722
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD1 RGPD2	1.36e-02	115	28	2	769
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB41 KLHL18	1.82e-02	134	28	2	861
Coexpression	COATES_MACROPHAGE_M1_VS_M2_UP	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	2.77e-07	102	36	5	MM749
Coexpression	DURAND_STROMA_NS_UP	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681	6.60e-06	194	36	5	MM962
Coexpression	TERAO_AOX4_TARGETS_SKIN_DN	ZNF729 ZNF91 ZNF99	7.61e-06	28	36	3	MM925
Coexpression	MIKKELSEN_NPC_ICP_WITH_H3K4ME3	ZNF729 ZNF91 ZNF493 ZNF99 ZNF681 ZNF254	5.42e-05	497	36	6	MM863
ToppCell	droplet-Heart-nan-24m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIP1R ADCY10 ADGRF5 ALDOB	2.24e-06	115	36	4	e11128262ba1e2a7053b1b6c039f1aab37d2ce27
Disease	smoking status measurement, triglyceride measurement	ZNF729 ZNF676	2.16e-05	6	36	2	EFO_0004530, EFO_0006527
Disease	beta-Ala-His dipeptidase measurement	ZNF681 ZNF254	4.03e-05	8	36	2	EFO_0008033
Disease	alcohol and nicotine codependence	RGPD1 RGPD2	1.12e-04	13	36	2	EFO_0004776
Disease	response to hydrochlorothiazide, fasting blood glucose measurement	ZNF626 PMFBP1	1.45e-03	46	36	2	EFO_0004465, EFO_0005202
Disease	complement factor H-related protein 1 measurement	ZBTB41 ZNF676	2.14e-03	56	36	2	EFO_0600054
Disease	venous thromboembolism, fibrinogen measurement	TRAFD1 PMFBP1	3.04e-03	67	36	2	EFO_0004286, EFO_0004623
Disease	childhood trauma measurement, alcohol consumption measurement	PLA2R1 ZNF254	3.41e-03	71	36	2	EFO_0007878, EFO_0007979

Protein segments in the cluster

Peptide	Gene	Start	Entry
KSRHDLVEHEKYCDQ	CCDC148	296	Q8NFR7
SEHKLPECHLVKEEY	ARHGEF40	421	Q8TER5
DHDLEHCQYVTEKVL	ALDOB	196	P05062
YEKEEELKEHLSHCI	ARHGEF38	201	Q9NXL2
YCEELLKNLEHHEVL	ADCY10	736	Q96PN6
LEKHICSVKHDDVYF	DDX60L	966	Q5H9U9
KFVKLCIEHVEEHGL	ARHGAP12	671	Q8IWW6
ICVYDKLHIKTHLDE	PALB2	76	Q86YC2
HTGKYEELIVCSHEI	HIP1R	896	O75146
HKCRDLVDEAKDYHL	KLHL18	251	O94889
DDLEEEHITKIYHCS	DDX11L8	221	A8MPP1
CEYSAHKEGVLKEEI	C20orf27	106	Q9GZN8
HHEFEVKYECLAEEI	DNAJC13	811	O75165
YLCIEEEKIIDHSHS	SLC39A10	596	Q9ULF5
EELCHEKEILEKYGH	AFP	96	P02771
EHVCKPKVEHLIGYE	LRRC8D	336	Q7L1W4
AIYKLKEHLLDCEGE	RGPD1	121	P0DJD0
HCKLKEDEVILYEEE	PMFBP1	131	Q8TBY8
ELSILKLKEHEDYCG	TRAFD1	96	O14545
YKLKEHLLDCEGEDG	RGPD2	131	P0DJD1
DLRTEHEKYLVKHCG	NARS2	346	Q96I59
TCKIEELGSELKEHY	POLA2	221	Q14181
GDICEYLHKDLHTIK	PLA2R1	156	Q13018
HHIKCCIEEDGDYKV	ADGRF5	586	Q8IZF2
HEIIHTGEKPYKCEE	ZNF99	471	A8MXY4
HKAIHAEEKPYKCEE	ZNF676	271	Q8N7Q3
LHTGEKLYECEECDK	ZNF320	406	A2RRD8
VHHDDKRYECDECGK	ZBTB41	596	Q5SVQ8
DEELLLVAYKECHKA	UBR1	556	Q8IWV7
HKRIHTEDKPYKCEE	ZNF626	331	Q68DY1
HEIIHTGEKPYKCEE	ZNF708	186	P17019
HKIIHAGEKLYKCEE	ZNF91	396	Q05481
IDHEKIHTGEKPYEC	ZNF569	286	Q5MCW4
HKRIHIGEKSYICEE	ZNF681	216	Q96N22
HRIIHTEEKPYKCEE	ZNF493	351	Q6ZR52
HEIIHAGEKLYKCEE	ZNF254	256	O75437
HKIIHVGEKLYKCEE	ZNF254	396	O75437
HEIIHTGEKPYKCEE	ZNF729	366	A6NN14