Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	BRK	CHD8 CHD7	4.25e-05	6	32	2	SM00592
Domain	BRK_domain	CHD8 CHD7	4.25e-05	6	32	2	IPR006576
Domain	BRK	CHD8 CHD7	4.25e-05	6	32	2	PF07533
Domain	Chromo_domain	CHD8 CHD7	7.67e-04	24	32	2	IPR023780
Domain	Chromo	CHD8 CHD7	9.01e-04	26	32	2	PF00385
Domain	CHROMO_2	CHD8 CHD7	1.05e-03	28	32	2	PS50013
Domain	CHROMO_1	CHD8 CHD7	1.05e-03	28	32	2	PS00598
Domain	SNF2_N	CHD8 CHD7	1.37e-03	32	32	2	PF00176
Domain	SNF2_N	CHD8 CHD7	1.37e-03	32	32	2	IPR000330
Domain	Chromodomain-like	CHD8 CHD7	1.37e-03	32	32	2	IPR016197
Domain	CHROMO	CHD8 CHD7	1.45e-03	33	32	2	SM00298
Domain	Chromo/shadow_dom	CHD8 CHD7	1.45e-03	33	32	2	IPR000953
Domain	DNA/RNA_helicase_DEAH_CS	CHD8 CHD7	1.63e-03	35	32	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD8 CHD7	1.92e-03	38	32	2	PS00690
Domain	C_TYPE_LECTIN_1	KLRG2 PKD1L2	8.27e-03	80	32	2	PS00615
Domain	Lectin_C	KLRG2 PKD1L2	9.08e-03	84	32	2	PF00059
Domain	CLECT	KLRG2 PKD1L2	9.08e-03	84	32	2	SM00034
Domain	C_TYPE_LECTIN_2	KLRG2 PKD1L2	9.29e-03	85	32	2	PS50041
Domain	C-type_lectin-like	KLRG2 PKD1L2	9.50e-03	86	32	2	IPR001304
Domain	SPRY	RYR1 SPSB2	9.72e-03	87	32	2	SM00449
Domain	SPRY	RYR1 SPSB2	1.13e-02	94	32	2	PF00622
Domain	SPRY_dom	RYR1 SPSB2	1.13e-02	94	32	2	IPR003877
Domain	B30.2/SPRY	RYR1 SPSB2	1.15e-02	95	32	2	IPR001870
Domain	B302_SPRY	RYR1 SPSB2	1.15e-02	95	32	2	PS50188
Pubmed	Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators.	CHD8 CHD7	9.84e-07	2	35	2	24211491
Pubmed	CHD8 interacts with CHD7, a protein which is mutated in CHARGE syndrome.	CHD8 CHD7	9.84e-07	2	35	2	20453063
Pubmed	Autism-linked CHD gene expression patterns during development predict multi-organ disease phenotypes.	CHD8 CHD7	2.95e-06	3	35	2	30277262
Pubmed	Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.	CHD8 CHD7	2.95e-06	3	35	2	30108144
Pubmed	The ATP-dependent chromatin remodeling enzymes CHD6, CHD7, and CHD8 exhibit distinct nucleosome binding and remodeling activities.	CHD8 CHD7	2.95e-06	3	35	2	28533432
Pubmed	Identification and characterization of FAM124B as a novel component of a CHD7 and CHD8 containing complex.	CHD8 CHD7	5.90e-06	4	35	2	23285124
Pubmed	CHARGE and Kabuki syndromes: a phenotypic and molecular link.	CHD8 CHD7	1.47e-05	6	35	2	24705355
Pubmed	SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity.	PDSS2 PKD1L2 TRIP4 LOX RYR1 DUSP11	2.76e-04	915	35	6	32393512
Pubmed	Array MAPPIT: high-throughput interactome analysis in mammalian cells.	SPSB2 FBXL6	3.15e-04	26	35	2	19159283
Pubmed	The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.	CHD8 CHD7 KDM6B	5.31e-04	157	35	3	30186101
Pubmed	LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition.	PKD1L2 SOWAHB CAPRIN2	6.47e-04	168	35	3	30631154
Pubmed	Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.	COL7A1 SSPOP FAM20B	7.28e-04	175	35	3	28071719
Disease	congenital heart disease (implicated_via_orthology)	CHD8 PDSS2 CHD7 USP17L15	1.36e-06	69	35	4	DOID:1682 (implicated_via_orthology)
Disease	CHARGE syndrome (implicated_via_orthology)	CHD8 CHD7	2.86e-05	7	35	2	DOID:0050834 (implicated_via_orthology)
Disease	airway responsiveness measurement	PDSS2 CAPRIN2	3.71e-04	24	35	2	EFO_0006897
Disease	1,5 anhydroglucitol measurement	MGAM PKD1L2	5.44e-04	29	35	2	EFO_0008009

Protein segments in the cluster

Peptide	Gene	Start	Entry
YGWGRWRDILSHGRF	CHD8	1456	Q9HCK8
LGSAGDRWAWRHRYG	AFDN-DT	181	Q9Y6Z5
WWDRLAPRGSGYHLL	FBXL6	26	Q8N531
GSVWGHRSFRDLPSW	CCNP	281	Q9H8S5
GSWRGRSSKSPAHWN	PDSS2	36	Q86YH6
YGWGRWTDILSHGRY	CHD7	1616	Q9P2D1
DTWTRHGALPRLWLY	KLHL30	541	Q0D2K2
LSRSTWPHWNGGDRE	MYO1A	641	Q9UBC5
RSTFPSSGRWAGHWL	MGAM	2406	O43451
DRHGVDYLTGSWWPI	KDM6B	1426	O15054
YSGRRWLDSHGTWLP	GPATCH3	121	Q96I76
TGAFGFHLWRRQWRP	LAG3	466	P18627
LRLWHDNSGDRPSWY	PKD1L2	1456	Q7Z442
SWLRSYWDRRGHPEA	HYI	261	Q5T013
YPVSRHSWVGAWRGP	KLRG2	341	A4D1S0
WHHPRSGWGRRRDFS	DUSP11	51	O75319
WLRLHRGAIYGSSWK	CAPRIN2	1101	Q6IMN6
SWYGSPRREGHYIHW	MANEAL	111	Q5VSG8
DFLPSRPRYSWEWHS	LOX	276	P28300
WTRVPGATGYRVSWH	COL7A1	706	Q02388
WSHGWYPGGKRALSS	GNRH2	26	O43555
ISWSGSHLRWGQPLR	RYR1	266	P21817
LGRAGWHWPAGRAAS	CARS2	21	Q9HA77
DHYSRLGWRLDLPWS	SSPOP	46	A2VEC9
SGISWGLYLELNHWR	SLC41A1	271	Q8IVJ1
RGWRHSLWVPSGEGS	SOWAHB	561	A6NEL2
LGASPSYRRWIWQHL	CNBD2	296	Q96M20
PTPWGYLRAEHWGAS	TLX1NB	36	P0CAT3
HPWGRTYREGKLARW	FAM20B	236	O75063
KRGYSRGLHAWEISW	SPSB2	81	Q99619
GRSWYTPHRGRLWIA	TRIP4	456	Q15650
WRWHQYRDTGSGSPG	PRR30	176	Q53SZ7
WSQWKYRPTRRGAHT	USP17L15	531	C9J2P7
LLLWGAPWTHGRRSN	TMX1	16	Q9H3N1
LPISSYLNHARWTWG	TMEM260	236	Q9NX78