Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	MDM2/MDM4 family protein binding	TP63 TP73	1.92e-04	13	32	2	GO:0097371
GeneOntologyMolecularFunction	p53 binding	TRIAP1 TP63 TP73	2.52e-04	77	32	3	GO:0002039
GeneOntologyCellularComponent	transcription factor TFTC complex	TRRAP ATXN7	3.42e-04	18	32	2	GO:0033276
GeneOntologyCellularComponent	SAGA complex	TRRAP ATXN7	6.66e-04	25	32	2	GO:0000124
Domain	P53	TP63 TP73	8.52e-06	3	32	2	PF00870
Domain	P53_tetramer	TP63 TP73	8.52e-06	3	32	2	PF07710
Domain	P53	TP63 TP73	8.52e-06	3	32	2	PS00348
Domain	-	TP63 TP73	8.52e-06	3	32	2	4.10.170.10
Domain	p53_DNA-bd	TP63 TP73	8.52e-06	3	32	2	IPR011615
Domain	p53_tumour_suppressor	TP63 TP73	8.52e-06	3	32	2	IPR002117
Domain	p53_tetrameristn	TP63 TP73	8.52e-06	3	32	2	IPR010991
Domain	p53/RUNT-type_TF_DNA-bd	TP63 TP73	4.25e-05	6	32	2	IPR012346
Domain	-	TP63 TP73	4.25e-05	6	32	2	2.60.40.720
Domain	CHCH	CHCHD2 TRIAP1	7.04e-04	23	32	2	PS51808
Domain	ZnF_U1	ZFHX4 TUT7	1.12e-03	29	32	2	SM00451
Domain	Znf_U1	ZFHX4 TUT7	1.12e-03	29	32	2	IPR003604
Domain	BTB	ZBTB38 RHOBTB3 KBTBD8	1.44e-03	131	32	3	PF00651
Domain	Znf_C2H2	ZBTB38 ZFHX4 ZNF341 ATXN7 TUT7 ZFP1	2.18e-03	805	32	6	IPR007087
Domain	SAM_2	TP63 TP73	2.46e-03	43	32	2	PF07647
Domain	BTB	ZBTB38 RHOBTB3 KBTBD8	2.55e-03	160	32	3	PS50097
Domain	BTB	ZBTB38 RHOBTB3 KBTBD8	3.56e-03	180	32	3	SM00225
Domain	p53-like_TF_DNA-bd	TP63 TP73	3.71e-03	53	32	2	IPR008967
Domain	BTB/POZ_dom	ZBTB38 RHOBTB3 KBTBD8	3.84e-03	185	32	3	IPR000210
Domain	SKP1/BTB/POZ	ZBTB38 RHOBTB3 KBTBD8	4.08e-03	189	32	3	IPR011333
Domain	-	PHF2 RNF213 TRAF5 ZNF341	6.96e-03	449	32	4	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PHF2 RNF213 TRAF5 ZNF341	7.51e-03	459	32	4	IPR013083
Domain	ZINC_FINGER_C2H2_1	ZBTB38 ZFHX4 ZNF341 TUT7 ZFP1	9.74e-03	777	32	5	PS00028
Domain	SAM	TP63 TP73	9.93e-03	88	32	2	SM00454
Domain	Znf_C2H2-like	ZBTB38 ZFHX4 ZNF341 ATXN7 ZFP1	1.07e-02	796	32	5	IPR015880
Domain	ZnF_C2H2	ZBTB38 ZFHX4 ZNF341 ATXN7 ZFP1	1.14e-02	808	32	5	SM00355
Domain	SAM_DOMAIN	TP63 TP73	1.15e-02	95	32	2	PS50105
Domain	SAM	TP63 TP73	1.20e-02	97	32	2	IPR001660
Pathway	PID_P53_DOWNSTREAM_PATHWAY	PTEN TRRAP TRIAP1 TP63 TP73	3.66e-06	137	25	5	M145
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_CYTOCHROME_C_RELEASE	TRIAP1 TP63 TP73	5.51e-06	20	25	3	M27628
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CELL_DEATH_GENES	TRIAP1 TP63 TP73	6.22e-05	44	25	3	M27499
Pathway	REACTOME_ACTIVATION_OF_PUMA_AND_TRANSLOCATION_TO_MITOCHONDRIA	TP63 TP73	1.08e-04	9	25	2	M26946
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_DEATH_RECEPTORS_AND_LIGANDS	TP63 TP73	1.97e-04	12	25	2	M27631
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_CASPASE_ACTIVATORS_AND_CASPASES	TP63 TP73	1.97e-04	12	25	2	M27630
Pathway	REACTOME_TP53_REGULATES_TRANSCRIPTION_OF_SEVERAL_ADDITIONAL_CELL_DEATH_GENES_WHOSE_SPECIFIC_ROLES_IN_P53_DEPENDENT_APOPTOSIS_REMAIN_UNCERTAIN	TP63 TP73	2.71e-04	14	25	2	M27629
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	TP63 TP73	2.71e-04	14	25	2	M27638
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS	TP63 TP73	2.71e-04	14	25	2	MM15341
Pathway	WP_TP53_NETWORK	TP63 TP73	5.07e-04	19	25	2	M39368
Pathway	KEGG_LINOLEIC_ACID_METABOLISM	CYP1A2 PLA2G4E	1.19e-03	29	25	2	M2920
Pathway	REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS	TP63 TP73	1.27e-03	30	25	2	M17814
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PHF2 RNF213 ATP7B ZFHX4 TRRAP ATXN7 RHOBTB3 TP73 ZFP1	5.03e-07	1116	32	9	31753913
Pubmed	p63 and p73 expression in extrahepatic bile duct carcinoma and their clinical significance.	TP63 TP73	8.20e-07	2	32	2	17385050
Pubmed	p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis.	TP63 TP73	8.20e-07	2	32	2	16413471
Pubmed	The role of p53 protein family in gastrointestinal malignancies.	TP63 TP73	8.20e-07	2	32	2	16557273
Pubmed	Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma.	TP63 TP73	8.20e-07	2	32	2	17018588
Pubmed	The 5th International p63/p73 Workshop: much more than just tumour suppression.	TP63 TP73	8.20e-07	2	32	2	22240899
Pubmed	Mechanism of TAp73 inhibition by ΔNp63 and structural basis of p63/p73 hetero-tetramerization.	TP63 TP73	8.20e-07	2	32	2	27716744
Pubmed	Conformational stability and activity of p73 require a second helix in the tetramerization domain.	TP63 TP73	8.20e-07	2	32	2	19763140
Pubmed	Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables.	TP63 TP73	8.20e-07	2	32	2	23095717
Pubmed	p73 and p63 regulate the expression of fibroblast growth factor receptor 3.	TP63 TP73	8.20e-07	2	32	2	20298673
Pubmed	DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells.	PTEN TP73	8.20e-07	2	32	2	19173293
Pubmed	ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization.	PTEN TP63	8.20e-07	2	32	2	21637289
Pubmed	Induction of apoptotic genes by a p73-phosphatase and tensin homolog (p73-PTEN) protein complex in response to genotoxic stress.	PTEN TP73	8.20e-07	2	32	2	21873427
Pubmed	P634A4 and TAp73 immunocytochemistry in liquid-based cervical cytology--potential biomarkers for diagnosis and progress prediction of cervical neoplasia.	TP63 TP73	8.20e-07	2	32	2	20081800
Pubmed	Distinct p63 and p73 Protein Interactions Predict Specific Functions in mRNA Splicing and Polyploidy Control in Epithelia.	TP63 TP73	8.20e-07	2	32	2	33375680
Pubmed	p63 and p73: roles in development and tumor formation.	TP63 TP73	8.20e-07	2	32	2	15280445
Pubmed	p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53.	TP63 TP73	8.20e-07	2	32	2	10373484
Pubmed	p63 and p73 do not contribute to p53-mediated lymphoma suppressor activity in vivo.	TP63 TP73	8.20e-07	2	32	2	16007185
Pubmed	TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy.	TP63 TP73	8.20e-07	2	32	2	24983500
Pubmed	The Role of p63 and p73 in tumor formation and progression: coming of age toward clinical usefulness. Commentary re: F. Koga et al., Impaired p63 expression associates with poor prognosis and uroplakin III expression in invasive urothelial carcinoma of the bladder. Clin. Cancer Res., 9: 5501-5507, 2003, and P. Puig et al., p73 Expression in human normal and tumor tissues: loss of p73alpha expression is associated with tumor progression in bladder Cancer. Clin. Cancer Res., 9: 5642-5651, 2003.	TP63 TP73	8.20e-07	2	32	2	14654522
Pubmed	Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation.	TP63 TP73	8.20e-07	2	32	2	28350813
Pubmed	Genome-wide mapping indicates that p73 and p63 co-occupy target sites and have similar dna-binding profiles in vivo.	TP63 TP73	8.20e-07	2	32	2	20644729
Pubmed	The p63/p73 network mediates chemosensitivity to cisplatin in a biologically defined subset of primary breast cancers.	TP63 TP73	8.20e-07	2	32	2	17446929
Pubmed	Tissue-specific expression of p73 and p63 isoforms in human tissues.	TP63 TP73	8.20e-07	2	32	2	34315849
Pubmed	p63 antagonizes p53 to promote the survival of embryonic neural precursor cells.	TP63 TP73	8.20e-07	2	32	2	19458240
Pubmed	While p73 is essential, p63 is completely dispensable for the development of the central nervous system.	TP63 TP73	8.20e-07	2	32	2	21293190
Pubmed	Neuronal survival and p73/p63/p53: a family affair.	TP63 TP73	2.46e-06	3	32	2	15359011
Pubmed	The p53-family members p63 and p73 inhibit insulin-like growth factor-I receptor gene expression in colon cancer cells.	TP63 TP73	2.46e-06	3	32	2	16181796
Pubmed	Glyoxalase II, a detoxifying enzyme of glycolysis byproduct methylglyoxal and a target of p63 and p73, is a pro-survival factor of the p53 family.	TP63 TP73	2.46e-06	3	32	2	16831876
Pubmed	Evaluating the Influence of a G-Quadruplex Prone Sequence on the Transactivation Potential by Wild-Type and/or Mutant P53 Family Proteins through a Yeast-Based Functional Assay.	TP63 TP73	2.46e-06	3	32	2	33672023
Pubmed	p53 Family isoforms.	TP63 TP73	2.46e-06	3	32	2	18289041
Pubmed	The integrin alpha(v)beta(3-5) ligand MFG-E8 is a p63/p73 target gene in triple-negative breast cancers but exhibits suppressive functions in ER(+) and erbB2(+) breast cancers.	TP63 TP73	2.46e-06	3	32	2	21127199
Pubmed	Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages.	PTEN TP63	2.46e-06	3	32	2	25163637
Pubmed	Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage.	TP63 TP73	2.46e-06	3	32	2	17716971
Pubmed	Regulation and function of the p53-related proteins: same family, different rules.	TP63 TP73	2.46e-06	3	32	2	10754563
Pubmed	p53/p63/p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress.	TP63 TP73	2.46e-06	3	32	2	16601753
Pubmed	Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis.	TP63 TP73	2.46e-06	3	32	2	11957139
Pubmed	iASPP inhibits p53-independent apoptosis by inhibiting transcriptional activity of p63/p73 on promoters of proapoptotic genes.	TP63 TP73	2.46e-06	3	32	2	22538442
Pubmed	The emerging p53 gene family.	TP63 TP73	2.46e-06	3	32	2	10203277
Pubmed	The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complex.	TP63 TP73	2.46e-06	3	32	2	20485546
Pubmed	Melanocyte and keratinocyte carcinogenesis: p53 family protein activities and intersecting mRNA expression profiles.	TP63 TP73	2.46e-06	3	32	2	16363065
Pubmed	p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells.	TP63 TP73	2.46e-06	3	32	2	24809925
Pubmed	Crystal structures of the DNA-binding domain tetramer of the p53 tumor suppressor family member p73 bound to different full-site response elements.	TP63 TP73	2.46e-06	3	32	2	23243311
Pubmed	p53, p63 and p73--solos, alliances and feuds among family members.	TP63 TP73	2.46e-06	3	32	2	11825686
Pubmed	The dominant-negative interplay between p53, p63 and p73: A family affair.	TP63 TP73	2.46e-06	3	32	2	27589690
Pubmed	ΔNp63 regulates select routes of reprogramming via multiple mechanisms.	TP63 TP73	2.46e-06	3	32	2	24013722
Pubmed	Interaction between TP63 and MDM2 genes and the risk of recurrent pregnancy loss.	TP63 TP73	2.46e-06	3	32	2	25218545
Pubmed	The p53 family: guardians of maternal reproduction.	TP63 TP73	2.46e-06	3	32	2	21427767
Pubmed	Physical interaction with Yes-associated protein enhances p73 transcriptional activity.	TP63 TP73	2.46e-06	3	32	2	11278685
Pubmed	[Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].	TP63 TP73	2.46e-06	3	32	2	19119599
Pubmed	p63 and p73 are not required for the development and p53-dependent apoptosis of T cells.	TP63 TP73	2.46e-06	3	32	2	15261144
Pubmed	Expression of p53 family in scars.	TP63 TP73	2.46e-06	3	32	2	14757278
Pubmed	Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity.	TP63 TP73	2.46e-06	3	32	2	22075982
Pubmed	Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family.	TP63 TP73	2.46e-06	3	32	2	15837625
Pubmed	Structural evolution of p53, p63, and p73: implication for heterotetramer formation.	TP63 TP73	2.46e-06	3	32	2	19815500
Pubmed	S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation.	TP63 TP73	2.46e-06	3	32	2	16449968
Pubmed	deltaEF1 repressor controls selectively p53 family members during differentiation.	TP63 TP73	2.46e-06	3	32	2	16007124
Pubmed	ΔNp63α represses nuclear translocation of PTEN by inhibition of NEDD4-1 in keratinocytes.	PTEN TP63	2.46e-06	3	32	2	23589096
Pubmed	Expression of p53 family genes in urinary bladder cancer: correlation with disease aggressiveness and recurrence.	TP63 TP73	2.46e-06	3	32	2	24213852
Pubmed	Inactivation of p53 signaling by p73 or PTEN ablation results in a transformed phenotype that remains susceptible to Nutlin-3 mediated apoptosis.	PTEN TP73	2.46e-06	3	32	2	20305378
Pubmed	Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family.	TP63 TP73	2.46e-06	3	32	2	27447112
Pubmed	p63 and p73 are required for p53-dependent apoptosis in response to DNA damage.	TP63 TP73	2.46e-06	3	32	2	11932750
Pubmed	Tumor suppressors p53, p63TAα, p63TAy, p73α, and p73β use distinct pathways to repress telomerase expression.	TP63 TP73	2.46e-06	3	32	2	22496369
Pubmed	Regulation of the Activity in the p53 Family Depends on the Organization of the Transactivation Domain.	TP63 TP73	2.46e-06	3	32	2	30099987
Pubmed	How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors.	TP63 TP73	2.46e-06	3	32	2	24488880
Pubmed	A novel response element confers p63- and p73-specific activation of the WNT4 promoter.	TP63 TP73	2.46e-06	3	32	2	16343436
Pubmed	Novel therapeutic interventions for p53-altered tumors through manipulation of its family members, p63 and p73.	TP63 TP73	2.46e-06	3	32	2	26652033
Pubmed	Differential expression of p53, p63 and p73 proteins in human buccal squamous-cell carcinomas.	TP63 TP73	2.46e-06	3	32	2	12969350
Pubmed	p63 and p73 repress CXCR5 chemokine receptor gene expression in p53-deficient MCF-7 breast cancer cells during genotoxic stress.	TP63 TP73	4.92e-06	4	32	2	29107083
Pubmed	A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain.	TP63 TP73	4.92e-06	4	32	2	11238924
Pubmed	Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome.	TP63 TP73	4.92e-06	4	32	2	15607981
Pubmed	Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.	TP63 TP73	4.92e-06	4	32	2	31712410
Pubmed	Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.	TP63 TP73	4.92e-06	4	32	2	17336302
Pubmed	Identification of Daxx interacting with p73, one of the p53 family, and its regulation of p53 activity by competitive interaction with PML.	TP63 TP73	4.92e-06	4	32	2	12954772
Pubmed	E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.	TP63 TP73	4.92e-06	4	32	2	25146927
Pubmed	MicroRNA-20a-5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression.	PTEN TP63	4.92e-06	4	32	2	27019188
Pubmed	Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies.	TP63 TP73	4.92e-06	4	32	2	29988075
Pubmed	p73 and p63 protein stability: the way to regulate function?	TP63 TP73	4.92e-06	4	32	2	14555234
Pubmed	ASPP1 and ASPP2: common activators of p53 family members.	TP63 TP73	4.92e-06	4	32	2	14729977
Pubmed	Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.	TP63 TP73	4.92e-06	4	32	2	11925430
Pubmed	Functional interplay between MDM2, p63/p73 and mutant p53.	TP63 TP73	4.92e-06	4	32	2	25417702
Pubmed	TNF-α promotes c-REL/ΔNp63α interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer.	TP63 TP73	4.92e-06	4	32	2	21933882
Pubmed	IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo.	TP63 TP73	4.92e-06	4	32	2	25409149
Pubmed	Thymine-DNA glycosylase interacts with and functions as a coactivator of p53 family proteins.	TP63 TP73	4.92e-06	4	32	2	18951877
Pubmed	The transcriptional repressor hDaxx potentiates p53-dependent apoptosis.	TP63 TP73	4.92e-06	4	32	2	15339933
Pubmed	Physical interaction between Wilms tumor 1 and p73 proteins modulates their functions.	TP63 TP73	4.92e-06	4	32	2	10744705
Pubmed	The p53 family members have distinct roles during mammalian embryonic development.	TP63 TP73	4.92e-06	4	32	2	28211873
Pubmed	Glutamine-expanded ataxin-7 alters TFTC/STAGA recruitment and chromatin structure leading to photoreceptor dysfunction.	TRRAP ATXN7	8.19e-06	5	32	2	16494529
Pubmed	Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73.	TP63 TP73	8.19e-06	5	32	2	21088494
Pubmed	The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells.	TP63 TP73	8.19e-06	5	32	2	27889317
Pubmed	Molecular mechanism of mutant p53 stabilization: the role of HSP70 and MDM2.	TP63 TP73	8.19e-06	5	32	2	23251530
Pubmed	An anterograde pathway for sensory axon degeneration gated by a cytoplasmic action of the transcriptional regulator P53.	TP63 TP73	8.19e-06	5	32	2	33823136
Pubmed	p53 family members in myogenic differentiation and rhabdomyosarcoma development.	TP63 TP73	8.19e-06	5	32	2	17045206
Pubmed	Regulation of female reproduction by p53 and its family members.	TP63 TP73	8.19e-06	5	32	2	21402718
Pubmed	Biochemical and structural studies of ASPP proteins reveal differential binding to p53, p63, and p73.	TP63 TP73	8.19e-06	5	32	2	18275817
Pubmed	Three-dimensional reconstruction of protein networks provides insight into human genetic disease.	TP63 TP73	1.23e-05	6	32	2	22252508
Pubmed	Ataxin-7 is a subunit of GCN5 histone acetyltransferase-containing complexes.	TRRAP ATXN7	1.23e-05	6	32	2	15115762
Pubmed	Differential expression of microRNAs miR-21, miR-31, miR-203, miR-125a-5p and miR-125b and proteins PTEN and p63 in verrucous carcinoma of the head and neck.	PTEN TP63	1.23e-05	6	32	2	22690848
Pubmed	Activation of the PI3K/AKT/mTOR Pathway in Cajal-Retzius Cells Leads to Their Survival and Increases Susceptibility to Kainate-Induced Seizures.	PTEN TP73	1.72e-05	7	32	2	36982451
Pubmed	p53 and TAp63 participate in the recombination-dependent pachytene arrest in mouse spermatocytes.	TP63 TP73	1.72e-05	7	32	2	28617799
Interaction	NPIPB13 interactions	TP63 TP73	1.37e-05	4	31	2	int:NPIPB13
GeneFamily	Lysine acetyltransferases\|ATAC complex\|SAGA complex\|GCN5 related N-acetyltransferases	TRRAP ATXN7	2.27e-04	17	24	2	1059
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB38 RHOBTB3 KBTBD8	7.19e-04	134	24	3	861
Disease	testicular cancer (implicated_via_orthology)	TP63 TP73	1.07e-05	5	31	2	DOID:2998 (implicated_via_orthology)
Disease	cervix uteri carcinoma in situ (is_marker_for)	PTEN TP63 TP73	1.17e-05	42	31	3	DOID:8991 (is_marker_for)
Disease	Multiple congenital anomalies	PTEN TP63	1.44e-04	17	31	2	C0000772
Disease	Lung Neoplasms	CYP1A2 PTEN TP63 TP73	1.65e-04	265	31	4	C0024121
Disease	Malignant neoplasm of lung	CYP1A2 PTEN TP63 TP73	1.68e-04	266	31	4	C0242379
Disease	Liver Cirrhosis	CYP1A2 ATP7B PTEN	1.73e-04	103	31	3	C0023890
Disease	Fibrosis, Liver	CYP1A2 ATP7B PTEN	1.83e-04	105	31	3	C0239946
Disease	urinary bladder cancer (is_marker_for)	PTEN TP63 TP73	1.94e-04	107	31	3	DOID:11054 (is_marker_for)
Disease	Carcinoma of lung	PTEN TP63	2.67e-04	23	31	2	C0684249
Disease	ovarian neoplasm	ATP7B PTEN TP63	3.75e-04	134	31	3	C0919267
Disease	Malignant neoplasm of ovary	ATP7B PTEN TP63	4.00e-04	137	31	3	C1140680
Disease	breast cancer (is_implicated_in)	CYP1A2 PTEN TP73	5.21e-04	150	31	3	DOID:1612 (is_implicated_in)
Disease	Carcinomatosis	ATP7B PTEN TP63	6.64e-04	163	31	3	C0205699
Disease	Carcinoma, Spindle-Cell	ATP7B PTEN TP63	6.64e-04	163	31	3	C0205697
Disease	Undifferentiated carcinoma	ATP7B PTEN TP63	6.64e-04	163	31	3	C0205698
Disease	Anaplastic carcinoma	ATP7B PTEN TP63	6.64e-04	163	31	3	C0205696
Disease	Carcinoma	ATP7B PTEN TP63	6.76e-04	164	31	3	C0007097
Disease	Cutaneous Melanoma	PTEN TRRAP	8.54e-04	41	31	2	C0151779
Disease	Malignant neoplasm of kidney	ATP7B PTEN	1.03e-03	45	31	2	C0740457

Protein segments in the cluster

Peptide	Gene	Start	Entry
QNVVAQIKPFYTVKC	AZIN1	56	O14977
KYVPSVVCLQQVCHQ	ATP7B	101	P35670
QQPCLYEIKQFLECA	CHCHD2	111	Q9Y6H1
KQFLVTKNVPCYKRC	ATG3	71	Q9NT62
LNGFYIPKKCCVFVN	CYP1A2	396	P05177
IIYLPKSQKNICFNI	ITIH2	706	P19823
CQYPENILSFIKCVI	NEMP2	91	A6NFY4
LCQTCYPLFQQVVSK	OSTM1	111	Q86WC4
YLVVCNDCNQVVKPQ	ATXN7	146	O15265
ECAVAKLYPQCLQKV	KBTBD8	586	Q8NFY9
IPKCYVIICKQEINT	GPRC6A	831	Q5T6X5
LKQTCEYCTVQNIPF	PLA2G4E	736	Q3MJ16
LYCQIAKTCPIQIKV	TP73	151	O15350
LYCQIAKTCPIQIKV	TP63	201	Q9H3D4
CIVCAKLKQDPYLVN	FHIP2A	156	Q5W0V3
CNPQFVVCQLKVKIY	PTEN	211	P60484
CQCVDVVFYNPNLKK	RHOBTB3	251	O94955
NCKIVYVARNPKDCL	SULT1C3	131	Q6IMI6
KCYKCIVKQGQTLFI	PHF2	301	O75151
FCKQATLQFCLVKPV	TMEM184A	181	Q6ZMB5
ELQKICYNRFVPCKN	RNASE9	111	P60153
YPVFCPNNCAKIILK	TRAF5	191	O00463
KQCYLQQVKQFCIRV	RNF213	4256	Q63HN8
KIKNLVQPFICTYCD	ZFP1	176	Q6P2D0
QYQCKKCNVVFPRIF	ZFHX4	2266	Q86UP3
QVYKCVVKSCAQTFP	ZNF341	471	Q9BYN7
INNQIVKLKYCYTCK	ZDHHC9	131	Q9Y397
PCTDLFKRYQQCVQK	TRIAP1	36	O43715
VKYQVPCQTQTYVKC	XP32	56	Q5T750
PTQEPLVCKYCNKQF	ZBTB38	366	Q8NAP3
KFLNILDQVCIQCYK	TUT7	996	Q5VYS8
PIVDCFQKIRQQVKC	TRRAP	3071	Q9Y4A5
PEIKVCQQQPKLYLC	WFDC10A	36	Q9H1F0