Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	linoleic acid epoxygenase activity	CYP2C19 CYP2C9 CYP2C18	5.31e-07	4	103	3	GO:0071614
GeneOntologyMolecularFunction	(R)-limonene 6-monooxygenase activity	CYP2C19 CYP2C9	2.64e-05	2	103	2	GO:0052741
GeneOntologyMolecularFunction	(S)-limonene 6-monooxygenase activity	CYP2C19 CYP2C9	2.64e-05	2	103	2	GO:0018675
GeneOntologyMolecularFunction	(S)-limonene 7-monooxygenase activity	CYP2C19 CYP2C9	2.64e-05	2	103	2	GO:0018676
GeneOntologyMolecularFunction	limonene monooxygenase activity	CYP2C19 CYP2C9	2.64e-05	2	103	2	GO:0019113
GeneOntologyMolecularFunction	retinoic acid 4-hydroxylase activity	CYP2C19 CYP2C9 CYP2C18	4.66e-05	14	103	3	GO:0008401
GeneOntologyMolecularFunction	arachidonate 11,12-epoxygenase activity	CYP2C19 CYP2C9	1.57e-04	4	103	2	GO:0008405
GeneOntologyMolecularFunction	arachidonate epoxygenase activity	CYP2C19 CYP2C9 CYP2C18	2.49e-04	24	103	3	GO:0008392
GeneOntologyMolecularFunction	fatty acid omega-1 hydroxylase activity	CYP2C19 CYP2C9	2.61e-04	5	103	2	GO:0120502
GeneOntologyMolecularFunction	long-chain fatty acid omega-1 hydroxylase activity	CYP2C19 CYP2C9	2.61e-04	5	103	2	GO:0120319
GeneOntologyMolecularFunction	arachidonate 14,15-epoxygenase activity	CYP2C19 CYP2C9	2.61e-04	5	103	2	GO:0008404
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2C19 CYP2C9 CYP2C18	3.56e-04	27	103	3	GO:0008391
GeneOntologyMolecularFunction	histone H3K4 monomethyltransferase activity	KMT2C KMT2A	7.23e-04	8	103	2	GO:0140945
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor	CYP2C19 CYP2C9	7.23e-04	8	103	2	GO:0033695
GeneOntologyMolecularFunction	caffeine oxidase activity	CYP2C19 CYP2C9	7.23e-04	8	103	2	GO:0034875
GeneOntologyMolecularFunction	aromatase activity	CYP2C19 CYP2C9 CYP2C18	7.74e-04	35	103	3	GO:0070330
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C KMT2A	1.15e-03	10	103	2	GO:0140999
GeneOntologyMolecularFunction	estrogen 16-alpha-hydroxylase activity	CYP2C19 CYP2C9	1.41e-03	11	103	2	GO:0101020
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2C19 CYP2C9 CYP2C18	2.07e-03	49	103	3	GO:0016712
GeneOntologyCellularComponent	laminin-5 complex	LAMA3 LAMC2	1.46e-04	4	104	2	GO:0005610
Domain	ARM-type_fold	GBF1 DOCK9 ARMH1 BTAF1 TRRAP SERAC1 PRKDC HEATR5B PPP6R2 NIPBL	1.80e-05	339	103	10	IPR016024
Domain	DVL-1	DVL1P1 DVL1	3.01e-05	2	103	2	IPR008340
Domain	DUF4599	SPATA31C2 SPATA31D4 SPATA31D3	3.46e-05	12	103	3	PF15371
Domain	DUF4599	SPATA31C2 SPATA31D4 SPATA31D3	3.46e-05	12	103	3	IPR027970
Domain	ARM-like	ARMH1 BTAF1 TRRAP SERAC1 PRKDC HEATR5B PPP6R2 NIPBL	1.25e-04	270	103	8	IPR011989
Domain	ILWEQ_dom	HIP1R TLN2	1.79e-04	4	103	2	IPR002558
Domain	ILWEQ	HIP1R TLN2	1.79e-04	4	103	2	SM00307
Domain	Dishevelled	DVL1P1 DVL1	1.79e-04	4	103	2	PF02377
Domain	Spectrin_bsu	SPTBN2 SPTBN4	1.79e-04	4	103	2	IPR016343
Domain	ILWEQ	HIP1R TLN2	1.79e-04	4	103	2	PD011820
Domain	-	HIP1R TLN2	1.79e-04	4	103	2	1.20.1410.10
Domain	I_LWEQ	HIP1R TLN2	1.79e-04	4	103	2	PF01608
Domain	I_LWEQ	HIP1R TLN2	1.79e-04	4	103	2	PS50945
Domain	Dishevelled_fam	DVL1P1 DVL1	1.79e-04	4	103	2	IPR008339
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	1.79e-04	4	103	2	IPR003351
Domain	-	ARMH1 BTAF1 TRRAP SERAC1 PRKDC HEATR5B NIPBL	2.30e-04	222	103	7	1.25.10.10
Domain	FYrich_C	KMT2C KMT2A	2.98e-04	5	103	2	IPR003889
Domain	FYrich_N	KMT2C KMT2A	2.98e-04	5	103	2	IPR003888
Domain	FYRC	KMT2C KMT2A	2.98e-04	5	103	2	SM00542
Domain	FYRN	KMT2C KMT2A	2.98e-04	5	103	2	SM00541
Domain	FYRN	KMT2C KMT2A	2.98e-04	5	103	2	PF05964
Domain	FYRC	KMT2C KMT2A	2.98e-04	5	103	2	PF05965
Domain	FYRC	KMT2C KMT2A	2.98e-04	5	103	2	PS51543
Domain	FYRN	KMT2C KMT2A	2.98e-04	5	103	2	PS51542
Domain	FAT	TRRAP PRKDC	4.45e-04	6	103	2	PS51189
Domain	FATC	TRRAP PRKDC	4.45e-04	6	103	2	PS51190
Domain	FAT	TRRAP PRKDC	4.45e-04	6	103	2	PF02259
Domain	PIK-rel_kinase_FAT	TRRAP PRKDC	4.45e-04	6	103	2	IPR003151
Domain	FATC_dom	TRRAP PRKDC	4.45e-04	6	103	2	IPR003152
Domain	PIK_FAT	TRRAP PRKDC	4.45e-04	6	103	2	IPR014009
Domain	FATC	TRRAP PRKDC	4.45e-04	6	103	2	SM01343
Domain	HEAT_REPEAT	BTAF1 PRKDC HEATR5B NIPBL	6.05e-04	70	103	4	PS50077
Domain	DIX	DVL1P1 DVL1	6.21e-04	7	103	2	PF00778
Domain	DIX	DVL1P1 DVL1	6.21e-04	7	103	2	IPR001158
Domain	DIX	DVL1P1 DVL1	6.21e-04	7	103	2	PS50841
Domain	DAX	DVL1P1 DVL1	6.21e-04	7	103	2	SM00021
Domain	LAMININ_IVA	LAMA3 LAMC2	8.25e-04	8	103	2	PS51115
Domain	Laminin_B	LAMA3 LAMC2	8.25e-04	8	103	2	PF00052
Domain	LamB	LAMA3 LAMC2	8.25e-04	8	103	2	SM00281
Domain	Laminin_IV	LAMA3 LAMC2	8.25e-04	8	103	2	IPR000034
Domain	PH	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 AKAP13 TECPR1	8.81e-04	278	103	7	SM00233
Domain	PH_DOMAIN	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 AKAP13 TECPR1	9.00e-04	279	103	7	PS50003
Domain	PH_domain	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 AKAP13 TECPR1	9.19e-04	280	103	7	IPR001849
Domain	PH_dom-spectrin-type	SPTBN2 SPTBN4	1.06e-03	9	103	2	IPR001605
Domain	-	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 TLN2 AKAP13 TECPR1	1.45e-03	391	103	8	2.30.29.30
Domain	PH	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 AKAP13	1.69e-03	229	103	6	PF00169
Domain	Oxysterol-bd_CS	OSBPL7 OSBPL11	1.92e-03	12	103	2	IPR018494
Domain	Oxysterol_BP	OSBPL7 OSBPL11	1.92e-03	12	103	2	PF01237
Domain	Oxysterol-bd	OSBPL7 OSBPL11	1.92e-03	12	103	2	IPR000648
Domain	OSBP	OSBPL7 OSBPL11	1.92e-03	12	103	2	PS01013
Domain	Cyt_P450_E_grp-I	CYP2C19 CYP2C9 CYP2C18	1.95e-03	45	103	3	IPR002401
Domain	Inhibin_asu	BMP8B BMP8A	2.26e-03	13	103	2	IPR002405
Domain	PH_dom-like	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 TLN2 AKAP13 TECPR1	2.47e-03	426	103	8	IPR011993
Domain	FBOX	FBXL14 FBXL4 FBXW8	2.96e-03	52	103	3	SM00256
Domain	Cyt_P450_CS	CYP2C19 CYP2C9 CYP2C18	3.12e-03	53	103	3	IPR017972
Domain	Post-SET_dom	KMT2C KMT2A	3.44e-03	16	103	2	IPR003616
Domain	PostSET	KMT2C KMT2A	3.44e-03	16	103	2	SM00508
Domain	-	TRRAP PRKDC	3.44e-03	16	103	2	1.10.1070.11
Domain	PI3Kc	TRRAP PRKDC	3.44e-03	16	103	2	SM00146
Domain	AT_hook	KMT2C KMT2A	3.44e-03	16	103	2	PF02178
Domain	POST_SET	KMT2C KMT2A	3.44e-03	16	103	2	PS50868
Domain	CYTOCHROME_P450	CYP2C19 CYP2C9 CYP2C18	3.84e-03	57	103	3	PS00086
Domain	HEAT	BTAF1 PRKDC NIPBL	4.03e-03	58	103	3	IPR000357
Domain	-	CYP2C19 CYP2C9 CYP2C18	4.03e-03	58	103	3	1.10.630.10
Domain	p450	CYP2C19 CYP2C9 CYP2C18	4.03e-03	58	103	3	PF00067
Domain	PI3_PI4_kinase	TRRAP PRKDC	4.35e-03	18	103	2	PF00454
Domain	PI3_4_KINASE_1	TRRAP PRKDC	4.35e-03	18	103	2	PS00915
Domain	PI3_4_KINASE_2	TRRAP PRKDC	4.35e-03	18	103	2	PS00916
Domain	PI3/4_kinase_cat_dom	TRRAP PRKDC	4.35e-03	18	103	2	IPR000403
Domain	PI3_4_KINASE_3	TRRAP PRKDC	4.35e-03	18	103	2	PS50290
Domain	Cyt_P450	CYP2C19 CYP2C9 CYP2C18	4.44e-03	60	103	3	IPR001128
Domain	Leu-rich_rpt_Cys-con_subtyp	FBXL14 FBXL4	4.84e-03	19	103	2	IPR006553
Domain	LRR_CC	FBXL14 FBXL4	4.84e-03	19	103	2	SM00367
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	GBF1 DOCK9 FBXL14 L1CAM DVL1 HIP1R RAP1GAP2 LMTK2 TWNK BTAF1 TRRAP MST1R KMT2C BMP8B ZBED4 FLCN OGDHL TLN2 AKAP13 PRKDC	1.13e-10	1105	105	20	35748872
Pubmed	Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.	CYP2C19 CYP2C9 CYP2C18	2.67e-08	3	105	3	15102943
Pubmed	Cloning and expression of complementary DNAs for multiple members of the human cytochrome PH50IIC subfamily.	CYP2C19 CYP2C9 CYP2C18	2.67e-08	3	105	3	8095407
Pubmed	Biochemistry and molecular biology of the human CYP2C subfamily.	CYP2C19 CYP2C9 CYP2C18	1.07e-07	4	105	3	7704034
Pubmed	Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.	CYP2C19 CYP2C9 CYP2C18	1.07e-07	4	105	3	19706858
Pubmed	Cloning and expression of complementary DNAs for multiple members of the human cytochrome P450IIC subfamily.	CYP2C19 CYP2C9 CYP2C18	1.07e-07	4	105	3	2009263
Pubmed	Genetic variation in the CYP2C monooxygenase enzyme subfamily shows no association with longevity in a German population.	CYP2C19 CYP2C9 CYP2C18	1.07e-07	4	105	3	21798861
Pubmed	Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.	CYP2C19 CYP2C9 CYP2C18	1.07e-07	4	105	3	23755828
Pubmed	A genome-wide association study of acenocoumarol maintenance dosage.	CYP2C19 CYP2C9 CYP2C18	5.31e-07	6	105	3	19578179
Pubmed	Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins.	FBXL14 BAG3 SNX21 CHGB ODF2 SPATS2 EPHA8	6.63e-06	230	105	7	29513927
Pubmed	CD44 and CD27 delineate B-precursor stages with different recombination status and with an uneven distribution in nonmalignant and malignant hematopoiesis.	CD27 CD44	9.03e-06	2	105	2	18005092
Pubmed	Important amino acid residues that confer CYP2C19 selective activity to CYP2C9.	CYP2C19 CYP2C9	9.03e-06	2	105	2	18511451
Pubmed	Developmental expression of human hepatic CYP2C9 and CYP2C19.	CYP2C19 CYP2C9	9.03e-06	2	105	2	14634042
Pubmed	Hyaluronic acid synthase-1 expression regulates bladder cancer growth, invasion, and angiogenesis through CD44.	CD44 HAS1	9.03e-06	2	105	2	18199543
Pubmed	Mesenchymal subtype of glioblastomas with high DNA-PKcs expression is associated with better response to radiotherapy and temozolomide.	CD44 PRKDC	9.03e-06	2	105	2	28070830
Pubmed	CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.	CYP2C19 CYP2C9	9.03e-06	2	105	2	10908295
Pubmed	Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.	CYP2C19 CYP2C9	9.03e-06	2	105	2	1847130
Pubmed	Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17599801
Pubmed	Few alterations in clinical pathology and histopathology observed in a CYP2C18&19 humanized mice model.	CYP2C19 CYP2C18	9.03e-06	2	105	2	19038035
Pubmed	Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis.	BMP8B BMP8A	9.03e-06	2	105	2	9463357
Pubmed	The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.	BMP8B BMP8A	9.03e-06	2	105	2	8682296
Pubmed	Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes.	CD44 HAS1	9.03e-06	2	105	2	19148550
Pubmed	Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.	CYP2C19 CYP2C9	9.03e-06	2	105	2	15385837
Pubmed	[Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms].	CYP2C19 CYP2C9	9.03e-06	2	105	2	25518510
Pubmed	Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18.	CYP2C9 CYP2C18	9.03e-06	2	105	2	8333835
Pubmed	Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.	CYP2C19 CYP2C9	9.03e-06	2	105	2	15842554
Pubmed	Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.	CYP2C19 CYP2C9	9.03e-06	2	105	2	19136640
Pubmed	Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.	CYP2C19 CYP2C9	9.03e-06	2	105	2	35748067
Pubmed	Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.	CYP2C19 CYP2C9	9.03e-06	2	105	2	32587777
Pubmed	Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Iranian population.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17201743
Pubmed	CYP2C9 (2&3) and CYP2C19 (2&3) polymorphisms among children with nonlesional epilepsy: a single-center study.	CYP2C19 CYP2C9	9.03e-06	2	105	2	32683556
Pubmed	Transglutaminase 2 Binds to the CD44v6 Cytoplasmic Domain to Stimulate CD44v6/ERK1/2 Signaling and Maintain an Aggressive Cancer Phenotype.	TGM2 CD44	9.03e-06	2	105	2	37227250
Pubmed	Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.	CYP2C19 CYP2C9	9.03e-06	2	105	2	15855721
Pubmed	Hyaluronan synthase 1 (HAS1) produces a cytokine-and glucose-inducible, CD44-dependent cell surface coat.	CD44 HAS1	9.03e-06	2	105	2	24099991
Pubmed	The effects of CYP2C9 and CYP2C19 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of glipizide in Chinese subjects.	CYP2C19 CYP2C9	9.03e-06	2	105	2	19847408
Pubmed	CYP2C9 and CYP2C19 polymorphic forms are related to increased indisulam exposure and higher risk of severe hematologic toxicity.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17504998
Pubmed	Cytochrome P450 2C epoxygenases mediate photochemical stress-induced death of photoreceptors.	CYP2C19 CYP2C9	9.03e-06	2	105	2	24519941
Pubmed	Mouse liver CYP2C39 is a novel retinoic acid 4-hydroxylase. Its down-regulation offers a molecular basis for liver retinoid accumulation and fibrosis in aryl hydrocarbon receptor-null mice.	CYP2C19 CYP2C9	9.03e-06	2	105	2	14623888
Pubmed	Hyaluronic acid (HA) stimulates the in vitro expression of CD44 proteins but not HAS1 proteins in normal human epidermal keratinocytes (NHEKs) and is HA molecular weight dependent.	CD44 HAS1	9.03e-06	2	105	2	33908161
Pubmed	Targeting the Stromal Pro-Tumoral Hyaluronan-CD44 Pathway in Pancreatic Cancer.	CD44 HAS1	9.03e-06	2	105	2	33921242
Pubmed	Rapid testing of clopidogrel resistance by genotyping of CYP2C19 and CYP2C9 polymorphisms using denaturing on-chip capillary electrophoresis.	CYP2C19 CYP2C9	9.03e-06	2	105	2	22589111
Pubmed	CYP2C9 and CYP2C19 genetic polymorphisms: frequencies in the south Indian population.	CYP2C19 CYP2C9	9.03e-06	2	105	2	15660966
Pubmed	Association of galactose single-point test levels and phenytoin metabolic polymorphisms with gingival hyperplasia in patients receiving long-term phenytoin therapy.	CYP2C19 CYP2C9	9.03e-06	2	105	2	18154472
Pubmed	Inhibition of ron kinase blocks conversion of micrometastases to overt metastases by boosting antitumor immunity.	MST1R PRKDC	9.03e-06	2	105	2	23612011
Pubmed	Impact of age, gender and CYP2C9/2C19 genotypes on dose-adjusted steady-state serum concentrations of valproic acid-a large-scale study based on naturalistic therapeutic drug monitoring data.	CYP2C19 CYP2C9	9.03e-06	2	105	2	27353638
Pubmed	The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.	BMP8B BMP8A	9.03e-06	2	105	2	21277400
Pubmed	Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics of gliclazide MR in Chinese subjects.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17298483
Pubmed	Analysis of the Potential Association of Drug-Metabolizing Enzymes CYP2C93 and CYP2C193 Gene Variations With Type 2 Diabetes: A Case-Control Study.	CYP2C19 CYP2C9	9.03e-06	2	105	2	33115391
Pubmed	Contributions of CYP2C9/CYP2C19 genotypes and drug interaction to the phenytoin treatment in the Korean epileptic patients in the clinical setting.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17562299
Pubmed	Laminin 5 mutations in junctional epidermolysis bullosa: molecular basis of Herlitz vs. non-Herlitz phenotypes.	LAMA3 LAMC2	9.03e-06	2	105	2	11810295
Pubmed	Prevalence of CYP2C9 and CYP2C19 variants and the impact on clopidogrel efficacy in patients having CYPC19*2 variant.	CYP2C19 CYP2C9	9.03e-06	2	105	2	36960518
Pubmed	Characterization of drug-metabolizing enzymes CYP2C9, CYP2C19 polymorphisms in Tunisian, Kuwaiti and Bahraini populations.	CYP2C19 CYP2C9	9.03e-06	2	105	2	26690534
Pubmed	TSG-6 produced by hMSCs delays the onset of autoimmune diabetes by suppressing Th1 development and enhancing tolerogenicity.	CD44 PRKDC	9.03e-06	2	105	2	23349496
Pubmed	Covariate-based dose individualization of the cytotoxic drug indisulam to reduce the risk of severe myelosuppression.	CYP2C19 CYP2C9	9.03e-06	2	105	2	19199010
Pubmed	A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies.	CYP2C19 CYP2C9	9.03e-06	2	105	2	19358898
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	9.03e-06	2	105	2	8644734
Pubmed	Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage.	CYP2C19 CYP2C9	9.03e-06	2	105	2	34438105
Pubmed	Chromosomal organization of the cytochrome P450-2C gene family in the mouse: a locus associated with constitutive aryl hydrocarbon hydroxylase.	CYP2C19 CYP2C9	9.03e-06	2	105	2	2895926
Pubmed	Influence of CYP2C9 and CYP2C19 genetic polymorphisms on pharmacokinetics and pharmacodynamics of gliclazide in healthy Chinese Han volunteers.	CYP2C19 CYP2C9	9.03e-06	2	105	2	20831536
Pubmed	CYP2C9, but not CYP2C19, polymorphisms affect the pharmacokinetics and pharmacodynamics of glyburide in Chinese subjects.	CYP2C19 CYP2C9	9.03e-06	2	105	2	16198656
Pubmed	Differential expression of laminin-5/ladsin subunits in human tissues and cancer cell lines and their induction by tumor promoter and growth factors.	LAMA3 LAMC2	9.03e-06	2	105	2	9010770
Pubmed	Human BMP8A suppresses luteinization of rat granulosa cells via the SMAD1/5/8 pathway.	BMP8B BMP8A	9.03e-06	2	105	2	31940275
Pubmed	[Association between genetic polymorphisms of CYP2C19 and CYP2C9 and phenytoin serum concentration].	CYP2C19 CYP2C9	9.03e-06	2	105	2	15569425
Pubmed	Generation and characterization of novel cytochrome P450 Cyp2c gene cluster knockout and CYP2C9 humanized mouse lines.	CYP2C9 CYP2C18	9.03e-06	2	105	2	22918969
Pubmed	An association between the rs1799853 and rs1057910 polymorphisms of CYP2C9, the rs4244285 polymorphism of CYP2C19 and the prevalence rates of drug-resistant epilepsy in children.	CYP2C19 CYP2C9	9.03e-06	2	105	2	32567426
Pubmed	Role of CYP2C9 and CYP2C19 polymorphisms in patients with atherosclerosis.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17868191
Pubmed	Impact of CYP2C19 and CYP2C9 gene polymorphisms on sodium valproate plasma concentration in patients with epilepsy.	CYP2C19 CYP2C9	9.03e-06	2	105	2	32868386
Pubmed	LRP-1--CD44, a new cell surface complex regulating tumor cell adhesion.	CD44 LRP1	9.03e-06	2	105	2	22711991
Pubmed	CYP2C9 and CYP2C19 Allele and Haplotype Distributions in Four Mestizo Populations from Western Mexico: An Interethnic Comparative Study.	CYP2C19 CYP2C9	9.03e-06	2	105	2	27617498
Pubmed	Influence of the CYP2C9 AND CYP2C19 polymorphisms on phenytoin hydroxylation in healthy individuals from south India.	CYP2C19 CYP2C9	9.03e-06	2	105	2	16873909
Pubmed	Evidence that CYP2C19 is the major (S)-mephenytoin 4'-hydroxylase in humans.	CYP2C19 CYP2C18	9.03e-06	2	105	2	8110777
Pubmed	Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls.	CYP2C19 CYP2C9	9.03e-06	2	105	2	106274
Pubmed	Genetic polymorphism of CYP2C9 and CYP2C19 in a Bolivian population: an investigative and comparative study.	CYP2C19 CYP2C9	9.03e-06	2	105	2	15776277
Pubmed	Effect of cytochrome P450 2C19 and 2C9 amino acid residues 72 and 241 on metabolism of tricyclic antidepressant drugs.	CYP2C19 CYP2C9	9.03e-06	2	105	2	24492587
Pubmed	Phase I pharmacokinetic and pharmacogenomic study of E7070 administered once every 21 days.	CYP2C19 CYP2C9	9.03e-06	2	105	2	16232205
Pubmed	Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China.	CYP2C19 CYP2C9	9.03e-06	2	105	2	20845310
Pubmed	Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.	CYP2C19 CYP2C9	9.03e-06	2	105	2	9721182
Pubmed	CD44 and CD27 expression pattern in B cell precursor acute lymphoblastic leukemia and its clinical significance.	CD27 CD44	9.03e-06	2	105	2	23263849
Pubmed	Tissue transglutaminase interacts with protein kinase A anchor protein 13 in prostate cancer.	TGM2 AKAP13	9.03e-06	2	105	2	16301118
Pubmed	Cytochrome P450 polymorphisms in patients with Behcet's disease.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17269966
Pubmed	Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes.	CYP2C19 CYP2C9	9.03e-06	2	105	2	11950794
Pubmed	Genetic polymorphisms of CYP2C9 and CYP2C19 are not related to drug-induced idiosyncratic liver injury (DILI).	CYP2C19 CYP2C9	9.03e-06	2	105	2	17279092
Pubmed	Associations of CYP2C9 and CYP2C19 Pharmacogenetic Variation with Phenytoin-Induced Cutaneous Adverse Drug Reactions.	CYP2C19 CYP2C9	9.03e-06	2	105	2	32216088
Pubmed	cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.	CYP2C19 CYP2C9	9.03e-06	2	105	2	8130255
Pubmed	Membrane integration of recombinant human P450 forms.	CYP2C19 CYP2C9	9.03e-06	2	105	2	19534586
Pubmed	Stress-response protein RBM3 attenuates the stem-like properties of prostate cancer cells by interfering with CD44 variant splicing.	RBM3 CD44	9.03e-06	2	105	2	23667174
Pubmed	Inter-phenotypic differences in CYP2C9 and CYP2C19 metabolism: Bayesian meta-regression of human population variability in kinetics and application in chemical risk assessment.	CYP2C19 CYP2C9	9.03e-06	2	105	2	33232775
Pubmed	Cell-surface transglutaminase undergoes internalization and lysosomal degradation: an essential role for LRP1.	TGM2 LRP1	9.03e-06	2	105	2	17711877
Pubmed	Population estimation of the effects of cytochrome P450 2C9 and 2C19 polymorphisms on phenobarbital clearance in Japanese.	CYP2C19 CYP2C9	9.03e-06	2	105	2	17304159
Pubmed	Genetic Polymorphisms of CYP2C9/CYP2C19 in Chronic Obstructive Pulmonary Disease.	CYP2C19 CYP2C9	9.03e-06	2	105	2	32757668
Pubmed	Influence of CYP2C9 and CYP2C19 genetic polymorphisms on phenytoin-induced neurological toxicity in Indian epileptic patients.	CYP2C19 CYP2C9	9.03e-06	2	105	2	20390258
Pubmed	Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.	CYP2C19 CYP2C9	9.03e-06	2	105	2	19761366
Pubmed	Genetic polymorphisms of CYP2C9 and CYP2C19 in the Beninese and Belgian populations.	CYP2C19 CYP2C9	9.03e-06	2	105	2	14616425
Pubmed	A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44.	L1CAM CD44	9.03e-06	2	105	2	16229685
Pubmed	Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.	CYP2C19 CYP2C9	9.03e-06	2	105	2	12496751
Pubmed	Voriconazole metabolism, toxicity, and the effect of cytochrome P450 2C19 genotype.	CYP2C19 CYP2C9	9.03e-06	2	105	2	24403552
Pubmed	A Novel CYP2C-Haplotype Associated With Ultrarapid Metabolism of Escitalopram.	CYP2C19 CYP2C18	9.03e-06	2	105	2	33759177
Pubmed	Novel DNA sequence variations of cytochrome P450 genes in the Han Chinese population.	CYP2C19 CYP2C9 CYP2C18	9.50e-06	14	105	3	19290787
Pubmed	Association of warfarin dose with genes involved in its action and metabolism.	CYP2C19 CYP2C9 CYP2C18	1.46e-05	16	105	3	17048007
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	HNRNPM DVL1 RAP1GAP2 SNX21 ZBTB1 DENND4C FBXL4 FBXW8 DROSHA SPATS2 HEATR5B TAF13 PPP6R2	1.53e-05	1038	105	13	26673895
Interaction	CYP2C19 interactions	CYP2C19 CYP2C9 CYP2C18	1.25e-06	5	102	3	int:CYP2C19
Interaction	TOP3B interactions	GBF1 DOCK9 SPTBN2 FBXL14 L1CAM HNRNPM DVL1 HIP1R RAP1GAP2 LMTK2 TWNK BTAF1 TRRAP MST1R KMT2C BMP8B ZBED4 FLCN OGDHL TLN2 AKAP13 PRKDC	3.42e-06	1470	102	22	int:TOP3B
Interaction	LRRK1 interactions	FBXL14 BAG3 SNX21 CHGB ODF2 EPHA8	1.32e-05	102	102	6	int:LRRK1
Cytoband	10q24	CYP2C19 CYP2C9 GBF1 CYP2C18 TWNK	1.75e-08	35	105	5	10q24
Cytoband	9q21.32	KIF27 SPATA31D4 SPATA31D3	1.10e-05	19	105	3	9q21.32
Cytoband	Ensembl 112 genes in cytogenetic band chr10q23	CYP2C19 CYP2C9 CYP2C18 BTAF1 PIPSL	8.99e-05	195	105	5	chr10q23
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	KIF27 SPATA31D4 SPATA31D3 PRKACG	1.16e-03	199	105	4	chr9q21
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK9 SPTBN2 SPTBN4 OSBPL7 OSBPL11 AKAP13	1.34e-04	206	69	6	682
GeneFamily	EF-hand domain containing\|Spectrins	SPTBN2 SPTBN4	2.98e-04	7	69	2	1113
GeneFamily	Cytochrome P450 family 2	CYP2C19 CYP2C9 CYP2C18	3.19e-04	35	69	3	1001
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP8B BMP8A	7.72e-04	11	69	2	455
GeneFamily	Laminin subunits	LAMA3 LAMC2	9.24e-04	12	69	2	626
GeneFamily	Oxysterol binding proteins\|Pleckstrin homology domain containing	OSBPL7 OSBPL11	9.24e-04	12	69	2	670
GeneFamily	F-box and leucine rich repeat proteins	FBXL14 FBXL4	2.88e-03	21	69	2	558
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	L1CAM MST1R CD27 CD44 LRP1 FZD10	3.89e-03	394	69	6	471
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	DENND4C FLCN	4.07e-03	25	69	2	504
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C KMT2A	7.44e-03	34	69	2	487
ToppCell	droplet-Marrow-nan-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	L1CAM RAP1GAP2 ARMH1 CHGB DPEP2 LRP1 SERAC1	1.97e-07	175	105	7	cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCell	NS-critical-d_0-4-Myeloid-Mast_cell\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	NR2C1 ASTE1 RAP1GAP2 ARMH1 ODF2 BEX2	4.23e-06	179	105	6	6153e7a0eeae83e7d88f1a20093bf2113e8d66b1
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	CENPC RNF19A DOCK9 BTAF1 KMT2C KMT2A	6.33e-06	192	105	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 CAPSL TWNK TGM2 FGB FZD10	6.72e-06	194	105	6	715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CENPC BTAF1 KMT2C KMT2A AKAP13 NIPBL	7.99e-06	200	105	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	COVID-19\|World / Disease, condition lineage and cell class	RNF19A ZBTB1 KMT2C KMT2A AKAP13 NIPBL	7.99e-06	200	105	6	7dec470c379cd89f05a0f37c8628b21f136e52f0
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HIP1R MST1R BMP8B CD27 PPP6R2	2.84e-05	150	105	5	744050a1b665c6989f37141348af3df7579a73c9
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	BAG3 HIP1R MST1R BMP8B CD27	3.23e-05	154	105	5	874b1220337276489a89fcc9a39bc81ba6b68baf
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	CENPC RNF19A DOCK9 BTAF1 KMT2C	3.43e-05	156	105	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	Influenza_Severe-CD4+_T_naive\|Influenza_Severe / Disease group and Cell class	DOCK9 CD27 MYO15A BEX2 TMEM139	3.54e-05	157	105	5	287bdc4e455cd0160261a93d13538e0def49fcd4
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CYP2C18 SPTBN2 L1CAM HIP1R FYB2	3.87e-05	160	105	5	7064af50fc10e3ea03badf415306222b74db0f95
ToppCell	10x5'-GI_large-bowel-Lymphocytic_T_CD4-Tfh\|GI_large-bowel / Manually curated celltypes from each tissue	RNF19A CHGB TRRAP SLC3A1 TAF13	4.23e-05	163	105	5	4104d3b9748b39cb0744c9be76db21bdda566a0d
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	L1CAM RAP1GAP2 DPEP2 LRP1 IFI30	4.48e-05	165	105	5	11227bff52eed30b80937fdb1968d0b8e6d30365
ToppCell	facs-Marrow-Granulocytes-24m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	L1CAM RAP1GAP2 DPEP2 LRP1 IFI30	4.48e-05	165	105	5	036f9749048e5e50769cc3210339bf4da469215d
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CENPC RNF19A DOCK9 OPTN PRKDC	4.75e-05	167	105	5	83969c36ac44b96afc9aa09400a99fa2b487f7ff
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l4\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	L1CAM RAP1GAP2 TGM2 DPEP2 CD44	4.88e-05	168	105	5	4b5be7c6662eceddf90a65015f12908278d1664e
ToppCell	droplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	L1CAM RAP1GAP2 TGM2 DPEP2 CD44	4.88e-05	168	105	5	689c41f6e9f65381570991cc311cba49a57ec955
ToppCell	droplet-Heart-4Chambers-21m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP2 OPTN DPEP2 OSBPL7 TAF13	5.31e-05	171	105	5	e852d0e8589eecf4a2e5fea039b52a67c5d58dbd
ToppCell	Posterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Fezf2\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CAPSL GPR152 ZP2 MST1R	5.37e-05	87	105	4	aaca22b97a42a1c4a10c5da708d1462101814386
ToppCell	facs-BAT-Fat-18m-Myeloid-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAP1GAP2 DPEP2 CD44 LRP1 IFI30	5.46e-05	172	105	5	36fe66a8c0aecee7a19269be23210c0ed7abb155
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	LAMA3 LAMC2 MST1R OSBPL7 TMEM139	5.46e-05	172	105	5	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	facs-Liver-Non-hepatocytes-24m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RBM3 PTPN18 CD27 DPEP2 CD44	5.61e-05	173	105	5	ffa73bc5d6817ca018abd9494665b2fd935eb88f
ToppCell	3'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TULP2 CD44 IFI30 HAS1 TAF13	5.93e-05	175	105	5	cd42020fe57afeaadfbd3ef6d7375e66d71e9669
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial-N_cells_(NTS+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP2 CHGB SPTBN4 FGB FYB2	5.93e-05	175	105	5	97a58bc6ed2e8e359283d4214172c990c6e3755e
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTBN2 L1CAM CHGB OGDHL BEX2	6.09e-05	176	105	5	bfea433544c6d6b8ad55e50ca94c5574460c2e0b
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPTBN2 L1CAM CHGB OGDHL BEX2	6.09e-05	176	105	5	3c78dee7e1111a579fde6d401b9ecb4d5b8e782f
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-neuro-epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RAP1GAP2 CHGB SPTBN4 FGB FYB2	6.09e-05	176	105	5	fb718a6b07aa5d56600263280afa530bcb63db42
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____kidney_collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SGSM1 SPTBN2 L1CAM LAMC2 BMP8A	7.14e-05	182	105	5	75608f80fd570da499891dc02f8649d5428b896c
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	DOCK9 HIP1R ZBED4 OSBPL7 TAF13	7.51e-05	184	105	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	saliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	CENPC CD27 GRAP2 OSBPL7 KMT2A	7.91e-05	186	105	5	bbcd9062c0f6f65ca6f3cb101b6fa72ddd1e14fe
ToppCell	Substantia_nigra-Neuronal\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	SPTBN2 L1CAM RAP1GAP2 CHGB SPTBN4	7.91e-05	186	105	5	3f889083fcffe516388e9b03a5e23af2010ced33
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SPTBN2 CHGB SPTBN4 BEX2 EPHA8	8.53e-05	189	105	5	f57200c93d39c9bce1adba0a6a1c178c028dd86b
ToppCell	T_cells-GZMK+_CD8+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	OPTN CD27 GRAP2 CD44 KMT2A	8.53e-05	189	105	5	e2ca075aedf7c370ab4ede6272254ffd06cbcdec
ToppCell	Globus_pallidus-Neuronal\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	SPTBN2 L1CAM CHGB SPTBN4 KMT2A	8.74e-05	190	105	5	416de85d8841dac883faa6f5339b2fb461a09e82
ToppCell	COPD-Myeloid-Macrophage_Alveolar\|Myeloid / Disease state, Lineage and Cell class	DENND4C TGM2 LRP1 OSBPL11 HEATR5B	8.74e-05	190	105	5	9fc763d65470ba8858b973689c4d4358faab7dd3
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 L1CAM HIP1R CHGB FYB2	8.74e-05	190	105	5	078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SPTBN2 L1CAM HIP1R CHGB FYB2	9.18e-05	192	105	5	9e031bf93eb8757fdd0cc22f01b44e48f85532d5
ToppCell	Entopeduncular-Neuronal\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SGSM1 SPTBN2 L1CAM CHGB SPTBN4	9.18e-05	192	105	5	4c35e5c28a40b439044797ba1f06cb7c36b2a8de
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CENPC RNF19A HIP1R OPTN KMT2A	9.87e-05	195	105	5	ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal-Subcortical\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	L1CAM CHGB LHX9 OPTN BEX2	1.01e-04	196	105	5	bf8fe28193348342987d361c8e8b9e1d6d542678
ToppCell	healthy_donor-Lymphocytic-T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	DOCK9 OPTN CD27 GRAP2 KMT2A	1.04e-04	197	105	5	63d0f06e150e7eb800ecb70e97b9d12a01c84e37
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-1_mon-Neuronal\|1_mon / Sample Type, Dataset, Time_group, and Cell type.	L1CAM CHGB LHX9 OPTN BEX2	1.09e-04	199	105	5	f94307958cead25d38103fcbb35fa45011de1687
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TGM2 KMT2C CD44 IFI30 AKAP13	1.09e-04	199	105	5	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	L1CAM HIP1R CHGB OPTN BEX2	1.09e-04	199	105	5	5de2a32bc2e9c752eb19a013b1807949153728fc
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	DOCK9 BAG3 TGM2 OPTN KMT2A	1.11e-04	200	105	5	6f531a418ff25b59a543800cf4bce7b72404ce08
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DVL1 SNX21 FBXW8 DROSHA LRP1	1.11e-04	200	105	5	5ad3ea1cf1fcd4100966c5517bc7ed0a1af54317
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_epineurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	DVL1 BTAF1 SNX21 FBXW8 DROSHA	1.11e-04	200	105	5	be46efc899d06c55ee297bee3126f69bcdb2048b
Computational	Cytochrome P450.	CYP2C19 CYP2C9 CYP2C18	7.67e-05	14	66	3	MODULE_106
Drug	Salbutamol [18559-94-9]; Down 200; 16.8uM; MCF7; HT_HG-U133A	NR2C1 RNF19A DOCK9 HIP1R ZBTB1 TGM2 ZBED4 AKAP13 PPP6R2	2.38e-07	197	101	9	2306_DN
Drug	dapsone	CYP2C19 CYP2C9 CYP2C18 LAMA3 LHX9 TGM2	8.78e-07	73	101	6	CID000002955
Drug	4',5-dihydroxydiclofenac	CYP2C19 CYP2C9 CYP2C18	1.68e-06	6	101	3	CID003052567
Drug	3'-hydroxydiclofenac	CYP2C19 CYP2C9 CYP2C18	1.68e-06	6	101	3	CID000112230
Drug	Nicergoline; Up 200; 8.2uM; PC3; HT_HG-U133A	NR2C1 TRAF3 DOCK9 TGM2 CD44 LRP1 TLN2 PPP6R2	2.67e-06	196	101	8	2058_UP
Drug	4,5-dihydropyrazole-1,5-dicarboxylic acid 1-((4-chlorophenyl)-amide) 5-(2-oxo-2H-(1,3')bipyridinyl-6'-yl)-amide	CYP2C19 CYP2C9 CYP2C18	6.98e-06	9	101	3	ctd:C545880
Drug	Acenocoumarol	CYP2C19 CYP2C9 CYP2C18	6.98e-06	9	101	3	ctd:D000074
Drug	deltoin	CYP2C19 CYP2C9 CYP2C18 SLC3A1 BMP8B	1.60e-05	71	101	5	CID000021908
Drug	5-hydroxydiclofenac	CYP2C19 CYP2C9 CYP2C18	1.81e-05	12	101	3	CID003052566
Drug	dibenzylfluorescein	CYP2C19 CYP2C9	1.95e-05	2	101	2	ctd:C558664
Drug	geldanamycin; Down 200; 1uM; MCF7; HG-U133A	HIP1R RAP1GAP2 EXOC3 POMT1 MST1R KMT2A TLN2	2.40e-05	192	101	7	611_DN
Drug	4-hydroxycyclophosphamide	CYP2C19 CYP2C9 CD27 PRKDC	2.40e-05	38	101	4	CID000099735
Drug	Dehydroisoandosterone 3-acetate [853-23-6]; Down 200; 12.2uM; PC3; HT_HG-U133A	DOCK9 SPTBN2 LAMC2 PTPN18 OPTN PRKACG LRP1	2.73e-05	196	101	7	6673_DN
Drug	2'-(glutathion-S-yl)-deschlorodiclofenac	CYP2C19 CYP2C9 CYP2C18	3.71e-05	15	101	3	ctd:C586542
Drug	polybrominated biphenyl	CYP2C19 CYP2C9 CYP2C18 IFI30	4.32e-05	44	101	4	CID000042948
Drug	1,1,1-trichloro-2-(4-hydroxyphenyl)-2-(4-methoxyphenyl)ethane	CYP2C19 CYP2C9 CYP2C18	4.55e-05	16	101	3	ctd:C495657
Drug	tranylcypromine	CYP2C19 CYP2C9 LAMA3 LRP1 LOXL3	5.34e-05	91	101	5	CID000005530
Drug	GITC	CYP2C9 CYP2C18 TGM2	5.51e-05	17	101	3	CID000099462
Drug	Implanon	CYP2C19 CYP2C9 OSBPL7 OSBPL11	5.62e-05	47	101	4	CID000040976
Drug	picoxystrobin	CYP2C19 CYP2C9	5.83e-05	3	101	2	ctd:C556557
Drug	mono-N-demethyladinazolam	CYP2C19 CYP2C9	5.83e-05	3	101	2	ctd:C050132
Drug	2-hydroxychlorpropamide	CYP2C19 CYP2C9	5.83e-05	3	101	2	CID003082454
Drug	Delavirdine	CYP2C19 CYP2C9	5.83e-05	3	101	2	ctd:D020008
Drug	ethoxyresorufin	CYP2C19 CYP2C9 CYP2C18 GRAP2 HAS1	6.57e-05	95	101	5	CID000003294
Drug	Azamulinum	CYP2C19 CYP2C9 CYP2C18	6.59e-05	18	101	3	CID003086060
Drug	D 703	CYP2C19 CYP2C9 CYP2C18	6.59e-05	18	101	3	CID000054088
Drug	androst-2-en-3-ol	CYP2C19 CYP2C9 IFI30	6.59e-05	18	101	3	CID000166036
Drug	hydroxytolbutamide	CYP2C19 CYP2C9 CYP2C18	7.80e-05	19	101	3	CID000003656
Drug	Bortezomib	CYP2C19 CYP2C9 CENPC BAG3 TRRAP DENND4C GANAB GTF3C2 CD27 FLCN KMT2A PRKDC KIF22	8.51e-05	838	101	13	ctd:D000069286
Drug	NSC76436	CYP2C19 CYP2C9 FBXL14	9.14e-05	20	101	3	CID000002828
Drug	3C etc	CYP2C19 CYP2C9 CYP2C18	9.14e-05	20	101	3	CID000164045
Drug	1-(6-((2-(dimethylamino)ethyl)(methyl)amino)-1,3-dimethyl-1H-pyrazolo(3,4-b)pyridine-5-carbonyl)-3-(3-isopropoxyphenyl)urea	CYP2C19 CYP2C9	1.16e-04	4	101	2	ctd:C558737
Drug	methysticin	CYP2C19 CYP2C9	1.16e-04	4	101	2	ctd:C076881
Drug	rabeprazole-thioether	CYP2C19 CYP2C9	1.16e-04	4	101	2	ctd:C523099
Drug	7,8-dihydromethysticin	CYP2C19 CYP2C9	1.16e-04	4	101	2	ctd:C107882
Disease	X-21258 measurement	CYP2C19 CYP2C9 CYP2C18	3.78e-08	3	100	3	EFO_0800802
Disease	X-14473 measurement	CYP2C19 CYP2C18	1.14e-05	2	100	2	EFO_0021370
Disease	Junctional epidermolysis bullosa	LAMA3 LAMC2	3.40e-05	3	100	2	cv:C0079301
Disease	cyclo(leu-pro) measurement	CYP2C19 CYP2C18	3.40e-05	3	100	2	EFO_0800676
Disease	Junctional epidermolysis bullosa gravis of Herlitz	LAMA3 LAMC2	3.40e-05	3	100	2	cv:C0079683
Disease	EPIDERMOLYSIS BULLOSA, JUNCTIONAL 1B, SEVERE	LAMA3 LAMC2	3.40e-05	3	100	2	226700
Disease	hydrocephalus (implicated_via_orthology)	TMEM67 KIF27 L1CAM	3.52e-05	19	100	3	DOID:10908 (implicated_via_orthology)
Disease	platelet reactivity measurement, response to clopidogrel	CYP2C19 CYP2C18 PDE10A	6.37e-05	23	100	3	EFO_0004985, GO_1903493
Disease	Epidermolysis Bullosa Progressiva	LAMA3 LAMC2	6.79e-05	4	100	2	C0079297
Disease	Herlitz Disease	LAMA3 LAMC2	6.79e-05	4	100	2	C0079683
Disease	spinocerebellar ataxia type 5 (implicated_via_orthology)	SPTBN2 SPTBN4	6.79e-05	4	100	2	DOID:0050882 (implicated_via_orthology)
Disease	Papillary Renal Cell Carcinoma	L1CAM SPTBN4 TGM2 FLCN AKAP13	7.69e-05	128	100	5	C1306837
Disease	Renal Cell Carcinoma	L1CAM SPTBN4 TGM2 FLCN AKAP13	7.69e-05	128	100	5	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	L1CAM SPTBN4 TGM2 FLCN AKAP13	7.69e-05	128	100	5	C1266043
Disease	Chromophobe Renal Cell Carcinoma	L1CAM SPTBN4 TGM2 FLCN AKAP13	7.69e-05	128	100	5	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	L1CAM SPTBN4 TGM2 FLCN AKAP13	7.69e-05	128	100	5	C1266044
Disease	diabetes mellitus (implicated_via_orthology)	BMP8B LRP1 BMP8A	9.28e-05	26	100	3	DOID:9351 (implicated_via_orthology)
Disease	Adult junctional epidermolysis bullosa (disorder)	LAMA3 LAMC2	1.13e-04	5	100	2	C0268374
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	1.13e-04	5	100	2	DOID:11198 (is_implicated_in)
Disease	EPIDERMOLYSIS BULLOSA, JUNCTIONAL, LOCALISATA VARIANT (disorder)	LAMA3 LAMC2	1.13e-04	5	100	2	C2608084
Disease	junctional epidermolysis bullosa non-Herlitz type (implicated_via_orthology)	LAMA3 LAMC2	1.13e-04	5	100	2	DOID:0060738 (implicated_via_orthology)
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	L1CAM SPTBN4 TGM2 FLCN AKAP13	1.52e-04	148	100	5	C0279702
Disease	Junctional Epidermolysis Bullosa	LAMA3 LAMC2	1.69e-04	6	100	2	C0079301
Disease	S-6-hydroxywarfarin to S-warfarin ratio measurement	CYP2C19 CYP2C9 CYP2C18 RAP1GAP2	2.33e-04	88	100	4	EFO_0803332
Disease	junctional epidermolysis bullosa (is_implicated_in)	LAMA3 LAMC2	2.36e-04	7	100	2	DOID:3209 (is_implicated_in)
Disease	glycine conjugate of C10H14O2 (1) measurement	CYP2C9 CYP2C18	2.36e-04	7	100	2	EFO_0800655
Disease	hoarding disorder	DPEP2 TLN2 FYB2	2.49e-04	36	100	3	EFO_0803361
Disease	S-warfarin to R-warfarin ratio measurement	CYP2C19 CYP2C9 CYP2C18 RAP1GAP2	3.12e-04	95	100	4	EFO_0803331
Disease	Cornelia De Lange Syndrome	KMT2A NIPBL	3.14e-04	8	100	2	C0270972
Disease	Inherited neuropathies	SPTBN2 L1CAM TWNK	3.41e-04	40	100	3	C0598589
Disease	Mitochondrial DNA Deletion Syndromes	TWNK FBXL4	4.03e-04	9	100	2	cv:CN043632
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	CYP2C19 CYP2C18	4.03e-04	9	100	2	EFO_0600040
Disease	X-11308 measurement	CYP2C19 CYP2C9	6.13e-04	11	100	2	EFO_0800693
Disease	thymol sulfate measurement	CYP2C19 CYP2C9	7.34e-04	12	100	2	EFO_0021170
Disease	Acute Myeloid Leukemia, M1	KMT2C CD44 IFI30 KMT2A	8.79e-04	125	100	4	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	KMT2C CD44 IFI30 KMT2A	8.79e-04	125	100	4	C1879321
Disease	metabolonic lactone sulfate measurement	CYP2C9 CYP2C18	1.87e-03	19	100	2	EFO_0800659
Disease	Nephritis, Tubulointerstitial	CYP2C9 SLC3A1	2.29e-03	21	100	2	C0041349
Disease	Leukemia, Myelocytic, Acute	KMT2C CD44 IFI30 KMT2A	2.89e-03	173	100	4	C0023467
Disease	Nephritis, Interstitial	CYP2C9 SLC3A1	2.99e-03	24	100	2	C0027707

Protein segments in the cluster

Peptide	Gene	Start	Entry
HMLAMVEEARRLQGS	PTPN18	206	Q99952
MLEARTAGHMQTLAD	CD27	151	P26842
VRGLMAAMGNTDHSN	ARMH1	326	Q6PIY5
AEMNHRSSMRVLGDV	AKAP13	1576	Q12802
LQQTELMDHRMATGE	CASP8AP2	816	Q9UKL3
MGIRGLMSFVEDHSN	ASTE1	1	Q2TB18
NEIDTMFMDRRQHPG	ABHD16B	151	Q9H3Z7
SVAMRAMNGESLDGR	RBM3	61	P98179
RSTGLLDSGMFMNIH	NR2C1	231	P13056
AQMEQSVGRLRSMHS	QRICH2	1486	Q9H0J4
MGMVRHTNESNLAGF	OR2G2	1	Q8NGZ5
RMGQGMGAIHLSEVR	LOXL3	361	P58215
MEQHGMVGSEISSSR	KMT2C	3431	Q8NEZ4
EHARAQMRAQMNIGD	MAGED4	626	Q96JG8
SASAGLLEQMRHMET	LAMA3	1851	Q16787
GIQMNSRMRAHSPAE	FLCN	51	Q8NFG4
HRLMQAMGRAQQQGS	MYO15A	2186	Q9UKN7
VTTQGSMIRRMHLNG	LRP1	3076	Q07954
GLDHMASSIERMGQT	HNRNPM	461	P52272
NLMVSGNMDGRVRIH	FBXW8	446	Q8N3Y1
GASQLMGENRTMTIH	FGB	386	P02675
LEMGNAARHTGTTQM	KIF27	186	Q86VH2
SGGHIQGIMEEMERR	LHX9	26	Q9NQ69
RRRGHNEMDEPMFTQ	OGDHL	496	Q9ULD0
MAAGGSTQQRRREMA	KIF22	1	Q14807
LNNQSHRDRVIGLMM	PDE10A	646	Q9Y233
DMQRGVHGRLMDNST	NIPBL	1811	Q6KC79
MDTTMEADLGATGHR	GPR152	1	Q8TDT2
GTAMSHEIRLMAEGA	L1CAM	121	P32004
LRSEQEHMRGDSQTM	LMTK2	226	Q8IWU2
MMGHEQLSTDRIAAQ	TWNK	521	Q96RR1
HISDDGINRMVRQMH	FBXL14	316	Q8N1E6
QSRRDDLEALGHMFM	CSNK1G3	226	Q9Y6M4
MESIQGEARRGGTME	PIPSL	311	A2A3N6
GEARRGGTMETDDHM	PIPSL	316	A2A3N6
MANITRMANHTGRLD	OR2T29	1	Q8NH02
RHGDMVQLVHGMTTR	POMT1	396	Q9Y6A1
RMPNLMGHENQREAA	FZD10	51	Q9ULW2
IEDMMNQARHASSGV	HIP1R	801	O75146
MAATDHSNQLRMAGL	HEATR5B	1301	Q9P2D3
GMGSFGRVMLVRHQE	PRKACG	51	P22612
IGRNRSPCMQDRGHM	CYP2C19	331	P33261
TGMMHARLQQLGSLD	DOCK9	1356	Q9BZ29
MRDLQAMDRAHRIGQ	BTAF1	1731	O14981
MAGTARHDREMAIQA	CAPSL	1	Q8WWF8
MGRGHQAGRRMDMDS	CD44	461	P16070
QAGRRMDMDSSHSIT	CD44	466	P16070
GDRGMQLMHANAQRT	IFI30	181	P13284
RNSDRNMEEHEEMGN	CENPC	456	Q03188
ATRGEMMNTHRAIES	FBXL4	26	Q9UKA2
HRLGEPQARMREENM	BEX2	71	Q9BXY8
RTHDGQFTIMQLVGM	EPHA8	726	P29322
LRHMADGAREVGNMT	GON4L	931	Q3T8J9
MSFVNMVERDRALGH	BMP8A	106	Q7Z5Y6
SSMELHREENRESGM	DENND4C	1251	Q5VZ89
FGDDRHLTNRMLSMG	HAS1	336	Q92839
NRLGMMVDLSHVSDA	DPEP2	251	Q9H4A9
AEGMENMADAVTHAR	GBF1	106	Q92538
GMSNRSSIINEHMGS	KMT2A	2406	Q03164
MMSELEERARQQRGH	LAMC2	1141	Q13753
VGRNRSPCMQDRSHM	CYP2C18	331	P33260
MDNETGTESMVSHRR	DVL1	131	O14640
IGRNRSPCMQDRSHM	CYP2C9	331	P11712
MDNETGTESMVSHRR	DVL1P1	131	P54792
RMDSGNTRDMTLIHG	EXOC3	161	O60645
TGLGSEMNAALMHRR	GRAP2	246	O75791
HSPMMQVASGNGDRD	BAG3	6	O95817
MSFVNMVERDRALGH	BMP8B	106	P34820
MPVDNRNHNEGMVTR	CHGB	21	P05060
GMRRGNMGHLTRIAN	PPP6R2	471	O75170
REMMSHAEGQQRDLI	OSBPL11	221	Q9BXB4
LTMERDQLRDMHQGS	OSBPL7	321	Q9BZF2
DQLRDMHQGSELSRM	OSBPL7	326	Q9BZF2
MHQGSELSRMGVSEA	OSBPL7	331	Q9BZF2
SMESMRGHLQAQLRS	ODF2	341	Q5BJF6
FEDGGRQSLMEMQSR	OPTN	506	Q96CV9
RQSLMEMQSRHGART	OPTN	511	Q96CV9
GRSVHGHADTNMEEM	TMEM67	791	Q5HYA8
GHNQRMEFLGDSIMQ	DROSHA	1141	Q9NRR4
RNIMRVIGNMALNEH	SERAC1	316	Q96JX3
IRVRSHSMETMVGGQ	RAP1GAP2	501	Q684P5
HMGQRGRIQESLDLM	SPATA31C2	456	B4DYI2
QMTNVHTGRRNMLAG	FYB2	421	Q5VWT5
MATADGLRQRSGGME	GANAB	581	Q14697
DRMRMDAGEVTLVNH	SENP1	6	Q9P0U3
GMHDIVRSFRQTMDQ	SLC3A1	356	Q07837
MMHLSGNDSGVRLGQ	SPATA31D4	806	Q6ZUB0
TEMTHKAMSIGRQGR	TAF13	66	Q15543
RIRVGQSMNMGSDFD	TGM2	476	P21980
MMHLSGNDSGVRLGQ	SPATA31D3	806	P0C874
SNDPMNQGRHDSMGR	SPATS2	461	Q86XZ4
LMLMDQGSSRRHLGD	TRAF3	496	Q13114
HNQALMNMDARPTEG	TTC30B	291	Q8N4P2
MSQDNDTLMRDILGH	TULP2	1	O00295
GISEERDGMMSHGQL	ZNF19	106	P17023
DMSLHRQMGSDRDLQ	RNF19A	31	Q9NV58
DFMSTMDANGERIHG	SPTBN2	1216	O15020
MGGHLRMVEANSRGV	TECPR1	766	Q7Z6L1
MHRGTQEGAMASRLL	SNX21	1	Q969T3
HRFESLDQEMNSLMG	SPTBN4	921	Q9H254
GGAMDTHFANMRSLI	SGSM1	1016	Q2NKQ1
GDRHLNNFMVAMETG	PRKDC	3921	P78527
RMSVSADERGGLENM	ZBTB1	391	Q9Y2K1
HNQALMNMDARPTEG	TTC30A	291	Q86WT1
FSSMGDAGEMVRQAR	TLN2	816	Q9Y4G6
RREPMLRMQEGEGHS	GTF3C2	811	Q8WUA4
MTIRVMNNSAALRHG	ZP2	116	Q05996
LDNVTVAHMGTMDGR	MST1R	456	Q04912
QESGNGRDVLMRMLE	TRRAP	436	Q9Y4A5
MSGHHDSNRQVTMRR	SPATA6	116	Q9NWH7
QRRMASEGSMAQEGS	TMEM139	141	Q8IV31
NGSLGQSRLMMEHFE	ZBED4	1141	O75132