Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionandrosterone dehydrogenase (B-specific) activity

AKR1C3 AKR1C1 AKR1C2

3.08e-074863GO:0047042
GeneOntologyMolecularFunctionketoreductase activity

AKR1C3 AKR1C1 AKR1C2

3.08e-074863GO:0045703
GeneOntologyMolecularFunctionchlordecone reductase activity

AKR1C3 AKR1C1 AKR1C2

3.08e-074863GO:0047743
GeneOntologyMolecularFunctiontrans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:0047115
GeneOntologyMolecularFunction15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:0047020
GeneOntologyMolecularFunction17-beta-ketosteroid reductase (NADPH) activity

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:0072555
GeneOntologyMolecularFunction17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:0047006
GeneOntologyMolecularFunctionlithocholic acid binding

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:1902121
GeneOntologyMolecularFunctionketosteroid monooxygenase activity

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:0047086
GeneOntologyMolecularFunctionDelta4-3-oxosteroid 5beta-reductase activity

AKR1C3 AKR1C1 AKR1C2

7.67e-075863GO:0047787
GeneOntologyMolecularFunctiongeranylgeranyl reductase activity

AKR1C3 AKR1C1 AKR1C2

1.53e-066863GO:0045550
GeneOntologyMolecularFunction17-beta-hydroxysteroid dehydrogenase (NADP+) activity

AKR1C3 AKR1C1 AKR1C2

2.67e-067863GO:0072582
GeneOntologyMolecularFunction5alpha-androstane-3beta,17beta-diol dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

4.25e-068863GO:0047024
GeneOntologyMolecularFunctionandrosterone dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

4.25e-068863GO:0047023
GeneOntologyMolecularFunctionenone reductase activity

AKR1C3 AKR1C1 AKR1C2

4.25e-068863GO:0035671
GeneOntologyMolecularFunctionandrostan-3-alpha,17-beta-diol dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

6.36e-069863GO:0047044
GeneOntologyMolecularFunctionNADP+ binding

AKR1C3 AKR1C1 AKR1C2

6.36e-069863GO:0070401
GeneOntologyMolecularFunctiontestosterone 17-beta-dehydrogenase (NADP+) activity

AKR1C3 AKR1C1 AKR1C2

9.06e-0610863GO:0047045
GeneOntologyMolecularFunctionbile acid binding

AKR1C3 AKR1C1 AKR1C2

9.06e-0610863GO:0032052
GeneOntologyMolecularFunctionaldose reductase (NADPH) activity

AKR1C3 AKR1C1 AKR1C2

2.71e-0514863GO:0004032
GeneOntologyMolecularFunctionretinal dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

2.71e-0514863GO:0001758
GeneOntologyMolecularFunctionestradiol 17-beta-dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C1 AKR1C2

8.34e-0520863GO:0004303
GeneOntologyMolecularFunctionindanol dehydrogenase activity

AKR1C1 AKR1C2

1.09e-044862GO:0047718
GeneOntologyMolecularFunctionmonooxygenase activity

CYP19A1 AKR1C3 CYP2U1 AKR1C1 AKR1C2

1.39e-04115865GO:0004497
GeneOntologyMolecularFunctionall-trans-retinol dehydrogenase (NAD+) activity

AKR1C3 AKR1C1 AKR1C2

1.46e-0424863GO:0004745
GeneOntologyMolecularFunctionalcohol dehydrogenase (NAD+) activity

AKR1C3 AKR1C1 AKR1C2

1.87e-0426863GO:0004022
GeneOntologyMolecularFunctionNADPH binding

AKR1C3 AKR1C1 AKR1C2

1.87e-0426863GO:0070402
GeneOntologyMolecularFunctionalcohol dehydrogenase (NADP+) activity

AKR1C3 AKR1C1 AKR1C2

2.09e-0427863GO:0008106
GeneOntologyMolecularFunctionalcohol dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C1 AKR1C2

2.88e-0430863GO:0018455
GeneOntologyMolecularFunctionaldo-keto reductase (NADPH) activity

AKR1C3 AKR1C1 AKR1C2

3.50e-0432863GO:0004033
GeneOntologyMolecularFunctionsteroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C1 AKR1C2

3.83e-0433863GO:0033764
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C1 AKR1C2

4.19e-0434863GO:0016628
GeneOntologyMolecularFunctionsteroid dehydrogenase activity

AKR1C3 AKR1C1 AKR1C2

6.30e-0439863GO:0016229
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

AKR1C3 AKR1C1 AKR1C2

6.79e-0440863GO:0016709
GeneOntologyMolecularFunctiontestosterone dehydrogenase [NAD(P)+] activity

AKR1C3 AKR1C1

9.83e-0411862GO:0030283
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C1 AKR1C2

1.16e-0348863GO:0016620
GeneOntologyMolecularFunctionzinc ion binding

L3MBTL2 DTNA DBF4 ANKIB1 PAPPA PRKCG UPF1 HERC2 FBXL19 ZZEF1 PRDM2

1.51e-038918611GO:0008270
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

CYP19A1 AKR1C3 CYP2U1 AKR1C1 AKR1C2

1.52e-03194865GO:0016705
GeneOntologyMolecularFunctiontransition metal ion binding

L3MBTL2 DTNA DBF4 CYP19A1 ANKIB1 CYP2U1 PAPPA PRKCG UPF1 HERC2 FBXL19 ZZEF1 PRDM2

1.67e-0311898613GO:0046914
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the aldehyde or oxo group of donors

AKR1C3 AKR1C1 AKR1C2

1.81e-0356863GO:0016903
GeneOntologyMolecularFunctionoxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor

AKR1C3 AKR1C1 AKR1C2

2.21e-0360863GO:0016655
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

AKR1C3 AKR1C1 AKR1C2 BDH1

2.22e-03127864GO:0016616
GeneOntologyMolecularFunctionoxidoreductase activity, acting on the CH-CH group of donors

AKR1C3 AKR1C1 AKR1C2

2.43e-0362863GO:0016627
GeneOntologyMolecularFunctionNADP binding

AKR1C3 AKR1C1 AKR1C2

2.43e-0362863GO:0050661
GeneOntologyMolecularFunctionoxidoreductase activity, acting on CH-OH group of donors

AKR1C3 AKR1C1 AKR1C2 BDH1

2.99e-03138864GO:0016614
GeneOntologyBiologicalProcessresponse to jasmonic acid

AKR1C3 AKR1C1 AKR1C2

2.89e-074873GO:0009753
GeneOntologyBiologicalProcessprogesterone catabolic process

AKR1C3 AKR1C1 AKR1C2

2.89e-074873GO:0006709
GeneOntologyBiologicalProcesscellular response to jasmonic acid stimulus

AKR1C3 AKR1C1 AKR1C2

2.89e-074873GO:0071395
GeneOntologyBiologicalProcessC21-steroid hormone catabolic process

AKR1C3 AKR1C1 AKR1C2

2.89e-074873GO:0008208
GeneOntologyBiologicalProcesstestosterone biosynthetic process

CYP19A1 AKR1C3 AKR1C1 AKR1C2

5.17e-0716874GO:0061370
GeneOntologyBiologicalProcessfarnesol metabolic process

AKR1C3 AKR1C1 AKR1C2

7.20e-075873GO:0016487
GeneOntologyBiologicalProcessfarnesol catabolic process

AKR1C3 AKR1C1 AKR1C2

7.20e-075873GO:0016488
GeneOntologyBiologicalProcessnegative regulation of isoprenoid metabolic process

AKR1C3 AKR1C1 AKR1C2

7.20e-075873GO:0045827
GeneOntologyBiologicalProcesssesquiterpenoid catabolic process

AKR1C3 AKR1C1 AKR1C2

7.20e-075873GO:0016107
GeneOntologyBiologicalProcessolefinic compound catabolic process

AKR1C3 AKR1C1 AKR1C2

7.20e-075873GO:0120256
GeneOntologyBiologicalProcessnegative regulation of retinoic acid biosynthetic process

AKR1C3 AKR1C1 AKR1C2

7.20e-075873GO:1900053
GeneOntologyBiologicalProcesssesquiterpenoid metabolic process

AKR1C3 AKR1C1 AKR1C2

1.44e-066873GO:0006714
GeneOntologyBiologicalProcesspolyprenol catabolic process

AKR1C3 AKR1C1 AKR1C2

1.44e-066873GO:0016095
GeneOntologyBiologicalProcesshormone catabolic process

CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.67e-0621874GO:0042447
GeneOntologyBiologicalProcessresponse to prostaglandin D

AKR1C3 AKR1C1 AKR1C2

2.51e-067873GO:0071798
GeneOntologyBiologicalProcesscellular response to prostaglandin D stimulus

AKR1C3 AKR1C1 AKR1C2

2.51e-067873GO:0071799
GeneOntologyBiologicalProcessregulation of retinoic acid biosynthetic process

AKR1C3 AKR1C1 AKR1C2

2.51e-067873GO:1900052
GeneOntologyBiologicalProcessdaunorubicin metabolic process

AKR1C3 AKR1C1 AKR1C2

5.98e-069873GO:0044597
GeneOntologyBiologicalProcessdoxorubicin metabolic process

AKR1C3 AKR1C1 AKR1C2

8.51e-0610873GO:0044598
GeneOntologyBiologicalProcessregulation of isoprenoid metabolic process

AKR1C3 AKR1C1 AKR1C2

8.51e-0610873GO:0019747
GeneOntologyBiologicalProcessnegative regulation of vitamin metabolic process

AKR1C3 AKR1C1 AKR1C2

8.51e-0610873GO:0046137
GeneOntologyBiologicalProcesspolyketide metabolic process

AKR1C3 AKR1C1 AKR1C2

8.51e-0610873GO:0030638
GeneOntologyBiologicalProcessaminoglycoside antibiotic metabolic process

AKR1C3 AKR1C1 AKR1C2

8.51e-0610873GO:0030647
GeneOntologyBiologicalProcessregulation of testosterone biosynthetic process

AKR1C3 AKR1C1 AKR1C2

1.17e-0511873GO:2000224
GeneOntologyBiologicalProcessterpenoid catabolic process

AKR1C3 AKR1C1 AKR1C2

1.17e-0511873GO:0016115
GeneOntologyBiologicalProcesssteroid catabolic process

CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.24e-0534874GO:0006706
GeneOntologyBiologicalProcessolefinic compound biosynthetic process

CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.40e-0535874GO:0120255
GeneOntologyBiologicalProcessretinoic acid biosynthetic process

AKR1C3 AKR1C1 AKR1C2

2.55e-0514873GO:0002138
GeneOntologyBiologicalProcessisoprenoid catabolic process

AKR1C3 AKR1C1 AKR1C2

2.55e-0514873GO:0008300
GeneOntologyBiologicalProcessditerpenoid biosynthetic process

AKR1C3 AKR1C1 AKR1C2

3.18e-0515873GO:0016102
GeneOntologyBiologicalProcessC21-steroid hormone metabolic process

CYP19A1 AKR1C3 AKR1C1 AKR1C2

3.86e-0545874GO:0008207
GeneOntologyBiologicalProcessnegative regulation of hormone metabolic process

AKR1C3 AKR1C1 AKR1C2

3.90e-0516873GO:0032351
GeneOntologyBiologicalProcessregulation of vitamin metabolic process

AKR1C3 AKR1C1 AKR1C2

5.65e-0518873GO:0030656
GeneOntologyBiologicalProcessterpenoid biosynthetic process

AKR1C3 AKR1C1 AKR1C2

9.12e-0521873GO:0016114
GeneOntologyBiologicalProcessregulation of retinoic acid receptor signaling pathway

AKR1C3 AKR1C1 AKR1C2

9.12e-0521873GO:0048385
GeneOntologyBiologicalProcessretinal metabolic process

AKR1C3 AKR1C1 AKR1C2

9.12e-0521873GO:0042574
GeneOntologyBiologicalProcessketone catabolic process

AKR1C3 AKR1C1 AKR1C2

9.12e-0521873GO:0042182
GeneOntologyBiologicalProcessketone biosynthetic process

CYP19A1 AKR1C3 AKR1C1 AKR1C2

9.83e-0557874GO:0042181
GeneOntologyBiologicalProcessparturition

AKR1C3 AKR1C1 AKR1C2

1.05e-0422873GO:0007567
GeneOntologyBiologicalProcessglycoside metabolic process

AKR1C3 AKR1C1 AKR1C2

1.05e-0422873GO:0016137
GeneOntologyBiologicalProcessprogesterone metabolic process

AKR1C3 AKR1C1 AKR1C2

1.05e-0422873GO:0042448
GeneOntologyBiologicalProcesstertiary alcohol metabolic process

AKR1C3 AKR1C1 AKR1C2

1.05e-0422873GO:1902644
GeneOntologyBiologicalProcesscellular response to prostaglandin stimulus

AKR1C3 AKR1C1 AKR1C2

1.21e-0423873GO:0071379
GeneOntologyBiologicalProcessprimary alcohol catabolic process

AKR1C3 AKR1C1 AKR1C2

1.21e-0423873GO:0034310
GeneOntologyBiologicalProcessregulation of ketone biosynthetic process

AKR1C3 AKR1C1 AKR1C2

1.76e-0426873GO:0010566
GeneOntologyBiologicalProcessregulation of mRNA splicing, via spliceosome

CELF5 AKR1C3 UPF1 AKR1C1 AKR1C2

2.17e-04129875GO:0048024
GeneOntologyBiologicalProcessnegative regulation of mRNA splicing, via spliceosome

AKR1C3 AKR1C1 AKR1C2

2.20e-0428873GO:0048025
GeneOntologyBiologicalProcesspolyprenol metabolic process

AKR1C3 AKR1C1 AKR1C2

2.45e-0429873GO:0016093
GeneOntologyBiologicalProcessnegative regulation of mRNA processing

AKR1C3 AKR1C1 AKR1C2

2.45e-0429873GO:0050686
GeneOntologyBiologicalProcesspositive regulation of endothelial cell apoptotic process

AKR1C3 AKR1C1 AKR1C2

3.29e-0432873GO:2000353
GeneOntologyBiologicalProcessnegative regulation of RNA splicing

AKR1C3 AKR1C1 AKR1C2

3.61e-0433873GO:0033119
GeneOntologyBiologicalProcessresponse to prostaglandin

AKR1C3 AKR1C1 AKR1C2

4.68e-0436873GO:0034694
GeneOntologyBiologicalProcessisoprenoid biosynthetic process

AKR1C3 AKR1C1 AKR1C2

4.68e-0436873GO:0008299
GeneOntologyBiologicalProcessretinoic acid receptor signaling pathway

AKR1C3 AKR1C1 AKR1C2

5.50e-0438873GO:0048384
GeneOntologyBiologicalProcessregulation of mRNA processing

CELF5 AKR1C3 UPF1 AKR1C1 AKR1C2

5.52e-04158875GO:0050684
GeneOntologyBiologicalProcessretinoic acid metabolic process

AKR1C3 AKR1C1 AKR1C2

6.40e-0440873GO:0042573
GeneOntologyBiologicalProcesscellular response to fatty acid

AKR1C3 AKR1C1 AKR1C2

7.39e-0442873GO:0071398
GeneOntologyBiologicalProcessmRNA splicing, via spliceosome

CELF5 CTNNBL1 AKR1C3 DDX20 UPF1 AKR1C1 AKR1C2

7.96e-04358877GO:0000398
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions with bulged adenosine as nucleophile

CELF5 CTNNBL1 AKR1C3 DDX20 UPF1 AKR1C1 AKR1C2

7.96e-04358877GO:0000377
GeneOntologyBiologicalProcessRNA splicing, via transesterification reactions

CELF5 CTNNBL1 AKR1C3 DDX20 UPF1 AKR1C1 AKR1C2

8.49e-04362877GO:0000375
GeneOntologyBiologicalProcessresponse to estrogen

KMT2D AKR1C3 AKR1C1 AKR1C2

9.50e-04103874GO:0043627
GeneOntologyBiologicalProcessolefinic compound metabolic process

CYP19A1 AKR1C3 CYP2U1 AKR1C1 AKR1C2

9.93e-04180875GO:0120254
GeneOntologyBiologicalProcessregulation of G protein-coupled receptor signaling pathway

GPRASP1 MET GPR158 GUCY2F GRM5

1.02e-03181875GO:0008277
GeneOntologyBiologicalProcessalcohol catabolic process

AKR1C3 AKR1C1 AKR1C2

1.03e-0347873GO:0046164
GeneOntologyBiologicalProcessregulation of steroid biosynthetic process

AKR1C3 DDX20 AKR1C1 AKR1C2

1.06e-03106874GO:0050810
GeneOntologyBiologicalProcessnuclear receptor-mediated signaling pathway

KMT2D AKR1C3 DNAJA1 AKR1C1 AKR1C2

1.65e-03202875GO:0141193
GeneOntologyBiologicalProcessprostaglandin metabolic process

AKR1C3 AKR1C1 AKR1C2

1.71e-0356873GO:0006693
GeneOntologyBiologicalProcessprostanoid metabolic process

AKR1C3 AKR1C1 AKR1C2

1.80e-0357873GO:0006692
GeneOntologyBiologicalProcessregulation of RNA splicing

CELF5 AKR1C3 UPF1 AKR1C1 AKR1C2

1.84e-03207875GO:0043484
GeneOntologyBiologicalProcessregulation of hormone metabolic process

AKR1C3 AKR1C1 AKR1C2

1.89e-0358873GO:0032350
GeneOntologyBiologicalProcesssteroid biosynthetic process

CYP19A1 AKR1C3 DDX20 AKR1C1 AKR1C2

1.92e-03209875GO:0006694
GeneOntologyBiologicalProcesspositive regulation of epithelial cell apoptotic process

AKR1C3 AKR1C1 AKR1C2

2.09e-0360873GO:1904037
GeneOntologyBiologicalProcessunsaturated fatty acid metabolic process

AKR1C3 CYP2U1 AKR1C1 AKR1C2

2.12e-03128874GO:0033559
MousePhenoparturition failure

AKR1C3 AKR1C1 AKR1C2

1.47e-0510713MP:0012010
MousePhenohypermyelination

AKR1C3 AKR1C1 AKR1C2

2.01e-0511713MP:0010050
MousePhenoincreased oligodendrocyte number

AKR1C3 AKR1C1 AKR1C2

3.46e-0513713MP:0010160
MousePhenolong gestation period

AKR1C3 AKR1C1 AKR1C2

5.47e-0515713MP:0002293
MousePhenoincreased circulating progesterone level

AKR1C3 AKR1C1 AKR1C2

5.47e-0515713MP:0005186
MousePhenolong stride length

AKR1C3 AKR1C1 AKR1C2

5.47e-0515713MP:0010540
MousePhenodecreased vocalization

NSF AKR1C3 AKR1C1 AKR1C2

8.49e-0546714MP:0020351
MousePhenoabnormal gestational length

AKR1C3 AKR1C1 AKR1C2

9.70e-0518713MP:0002292
MousePhenoabnormal circulating progesterone level

AKR1C3 PAPPA AKR1C1 AKR1C2

1.18e-0450714MP:0005184
MousePhenodysmyelination

AKR1C3 AKR1C1 AKR1C2

1.35e-0420713MP:0013438
MousePhenoabnormal progesterone level

AKR1C3 PAPPA AKR1C1 AKR1C2

1.60e-0454714MP:0011384
MousePhenoprostate gland dorsolateral lobe hyperplasia

CYP19A1 ELAC2

2.52e-045712MP:0031369
MousePhenoprostate gland hyperplasia

CYP19A1 ELAC2

2.52e-045712MP:0000659
MousePhenodecreased oligodendrocyte number

AKR1C3 AKR1C1 AKR1C2

2.67e-0425713MP:0009808
MousePhenoabnormal coping response

KMT2D AFM ZNF175 ZZEF1

3.47e-0466714MP:0003062
MousePhenoprostate gland anterior lobe hyperplasia

CYP19A1 ELAC2

3.77e-046712MP:0005305
MousePhenoenlarged prostate gland anterior lobe

CYP19A1 ELAC2

3.77e-046712MP:0009738
MousePhenoenlarged prostate gland dorsolateral lobe

CYP19A1 ELAC2

3.77e-046712MP:0009739
MousePhenoabnormal ovulation cycle

CYP19A1 AKR1C3 DDX20 AKR1C1 AKR1C2

4.45e-04126715MP:0009344
MousePhenoprolonged diestrus

AKR1C3 AKR1C1 AKR1C2

4.62e-0430713MP:0009011
MousePhenoabnormal parturition

AKR1C3 AKR1C1 AKR1C2

6.14e-0433713MP:0002907
MousePhenoabnormal diestrus

AKR1C3 AKR1C1 AKR1C2

7.31e-0435713MP:0009010
MousePhenoabnormal stride length

KMT2D AKR1C3 AKR1C1 AKR1C2

7.93e-0482714MP:0012690
DomainALDOKETO_REDUCTASE_1

AKR1C3 AKR1C1 AKR1C2

9.93e-0610833PS00798
DomainAldo/ket_reductase_CS

AKR1C3 AKR1C1 AKR1C2

9.93e-0610833IPR018170
DomainAldo/keto_reductase

AKR1C3 AKR1C1 AKR1C2

9.93e-0610833IPR020471
DomainALDOKETO_REDUCTASE_2

AKR1C3 AKR1C1 AKR1C2

9.93e-0610833PS00062
DomainALDOKETO_REDUCTASE_3

AKR1C3 AKR1C1 AKR1C2

9.93e-0610833PS00063
Domain-

AKR1C3 AKR1C1 AKR1C2

4.55e-05168333.20.20.100
DomainNADP_OxRdtase_dom

AKR1C3 AKR1C1 AKR1C2

5.50e-0517833IPR023210
DomainAldo_ket_red

AKR1C3 AKR1C1 AKR1C2

5.50e-0517833PF00248
DomainAldo/ket_red/Kv-b

AKR1C3 AKR1C1 AKR1C2

5.50e-0517833IPR001395
DomainZZ

DTNA HERC2 ZZEF1

6.58e-0518833PF00569
DomainZF_ZZ_2

DTNA HERC2 ZZEF1

6.58e-0518833PS50135
DomainZF_ZZ_1

DTNA HERC2 ZZEF1

6.58e-0518833PS01357
DomainZnf_ZZ

DTNA HERC2 ZZEF1

7.79e-0519833IPR000433
DomainZnF_ZZ

DTNA HERC2 ZZEF1

7.79e-0519833SM00291
DomainAPC_su10/DOC_dom

HERC2 ZZEF1

4.04e-047832IPR004939
DomainDOC

HERC2 ZZEF1

4.04e-047832PS51284
DomainAPC10

HERC2 ZZEF1

4.04e-047832SM01337
DomainANAPC10

HERC2 ZZEF1

4.04e-047832PF03256
DomainATPase_dyneun-rel_AAA

VWA8 DYNC1H1

1.72e-0314832IPR011704
DomainAAA_5

VWA8 DYNC1H1

1.72e-0314832PF07728
DomainRib_L2_dom2

SUPT5H HERC2

2.85e-0318832IPR014722
Domain-

SUPT5H HERC2

2.85e-03188322.30.30.30
DomainPLAC

ADAMTS16 ADAMTS14

3.18e-0319832PS50900
DomainPLAC

ADAMTS16 ADAMTS14

3.18e-0319832IPR010909
DomainGPCR_3

GPR158 GRM5

3.88e-0321832IPR000337
DomainARM-type_fold

GPRASP1 DNAJC13 UPF2 CEBPZ CTNNBL1 ELMO1

4.00e-03339836IPR016024
Domain7tm_3

GPR158 GRM5

4.25e-0322832PF00003
DomainG_PROTEIN_RECEP_F3_2

GPR158 GRM5

4.25e-0322832PS00980
DomainG_PROTEIN_RECEP_F3_3

GPR158 GRM5

4.25e-0322832PS00981
DomainG_PROTEIN_RECEP_F3_1

GPR158 GRM5

4.25e-0322832PS00979
DomainG_PROTEIN_RECEP_F3_4

GPR158 GRM5

4.25e-0322832PS50259
DomainGPCR_3_C

GPR158 GRM5

4.25e-0322832IPR017978
DomainADAM_spacer1

ADAMTS16 ADAMTS14

4.65e-0323832IPR010294
DomainADAM_spacer1

ADAMTS16 ADAMTS14

4.65e-0323832PF05986
DomainPeptidase_M12B_ADAM-TS

ADAMTS16 ADAMTS14

5.05e-0324832IPR013273
DomainMetalloPept_cat_dom

ADAMTS16 PAPPA ADAMTS14

5.63e-0381833IPR024079
Domain-

ADAMTS16 PAPPA ADAMTS14

5.63e-03818333.40.390.10
DomainGalactose-bd-like

LAMA1 HERC2 ZZEF1

8.48e-0394833IPR008979
Domain-

CALR3 LAMA1 PAPPA

8.73e-03958332.60.120.200
PathwayWP_BENZOAPYRENE_METABOLISM

AKR1C3 AKR1C1 AKR1C2

7.01e-069633M39344
PathwayKEGG_MEDICUS_ENV_FACTOR_METALS_TO_KEAP1_NRF2_SIGNALIG_PATHWAY

AKR1C3 AKR1C1 AKR1C2

7.01e-069633M47817
PathwayKEGG_MEDICUS_ENV_FACTOR_BENZO_A_PYRENRE_TO_CYP_MEDIATED_METABOLISM

AKR1C3 AKR1C1 AKR1C2

1.37e-0511633M47812
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C1 AKR1C2

2.36e-0513633M17842
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_24_HYDROXYCHOLESTEROL

AKR1C3 AKR1C1 AKR1C2

2.36e-0513633MM14747
PathwayWP_GLUCOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C1 AKR1C2

2.99e-0514633M46449
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C1 AKR1C2

2.99e-0514633M27074
PathwayWP_MINERALOCORTICOID_BIOSYNTHESIS

AKR1C3 AKR1C1 AKR1C2

2.99e-0514633M46453
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_27_HYDROXYCHOLESTEROL

AKR1C3 AKR1C1 AKR1C2

2.99e-0514633MM14748
PathwayREACTOME_SYNTHESIS_OF_PROSTAGLANDINS_PG_AND_THROMBOXANES_TX

AKR1C3 AKR1C1 AKR1C2

3.73e-0515633MM14870
PathwayKEGG_STEROID_HORMONE_BIOSYNTHESIS

CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.04e-0455634M14933
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C3 AKR1C1 AKR1C2

1.41e-0423633M1926
PathwayREACTOME_PREDNISONE_ADME

AKR1C3 AKR1C1 AKR1C2

1.41e-0423633MM16639
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS_VIA_7ALPHA_HYDROXYCHOLESTEROL

AKR1C3 AKR1C1 AKR1C2

1.41e-0423633MM14741
PathwayREACTOME_ARACHIDONIC_ACID_METABOLISM

AKR1C3 CYP2U1 AKR1C1 AKR1C2

1.56e-0461634MM14861
PathwayREACTOME_RA_BIOSYNTHESIS_PATHWAY

AKR1C3 AKR1C1 AKR1C2

2.57e-0428633MM15188
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C3 AKR1C1 AKR1C2

4.22e-0433633M5967
PathwayREACTOME_SYNTHESIS_OF_BILE_ACIDS_AND_BILE_SALTS

AKR1C3 AKR1C1 AKR1C2

4.22e-0433633MM14737
PathwayREACTOME_VISUAL_PHOTOTRANSDUCTION

GUCY2F AKR1C3 AKR1C1 AKR1C2

7.54e-0492634MM14881
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C1 AKR1C2

9.89e-0444633M499
PathwayWP_PROSTAGLANDIN_SYNTHESIS_AND_REGULATION

AKR1C3 AKR1C1 AKR1C2

1.06e-0345633M39355
PathwayREACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS

AKR1C3 AKR1C1 AKR1C2

1.06e-0345633MM15344
PathwayREACTOME_BILE_ACID_AND_BILE_SALT_METABOLISM

AKR1C3 AKR1C1 AKR1C2

1.06e-0345633MM14751
Pubmed

Aldo-keto reductase 1C subfamily genes in skin are UV-inducible: possible role in keratinocytes survival.

AKR1C3 AKR1C1 AKR1C2

1.57e-08388319320734
Pubmed

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis.

AKR1C3 AKR1C1 AKR1C2

1.57e-08388331780644
Pubmed

Aldo-keto reductases AKR1C1, AKR1C2 and AKR1C3 may enhance progesterone metabolism in ovarian endometriosis.

AKR1C3 AKR1C1 AKR1C2

1.57e-08388321232532
Pubmed

Altered expression of 3 alpha-hydroxysteroid dehydrogenases in human glaucomatous optic nerve head astrocytes.

AKR1C3 AKR1C1 AKR1C2

1.57e-08388313678667
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

GPRASP1 DNAJC13 DSTN GPR158 NSF N4BP2 SPTAN1 PRKCG UPF1 HERC2 BCOR GRM5 DNAJA1 TOP3B DYNC1H1

1.87e-08963881528671696
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

DNAJC13 DSTN SPOUT1 L3MBTL2 UPF2 CEBPZ SPTAN1 CTNNBL1 ANKIB1 PDCD11 DDX20 UPF1 HERC2 DNAJA1 MAP2K3 ELAC2 DYNC1H1

4.36e-081353881729467282
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

SPOUT1 UPF2 VWA8 CEBPZ SPTAN1 CTNNBL1 AKR1C3 PDCD11 ISG20L2 DDX20 UPF1 HERC2 PIPSL AKR1C1 AKR1C2 BDH1 DYNC1H1

5.27e-081371881736244648
Pubmed

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488320124700
Pubmed

Structure and activity of the murine type 5 17beta-hydroxysteroid dehydrogenase gene(1).

AKR1C3 AKR1C1 AKR1C2

6.25e-08488310500239
Pubmed

Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488316508162
Pubmed

AKR1C isoforms represent a novel cellular target for jasmonates alongside their mitochondrial-mediated effects.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488319487289
Pubmed

Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488314967952
Pubmed

Assignment of HSD17B5 encoding type 5 17 beta-hydroxysteroid dehydrogenase to human chromosome bands 10p15-->p14 and mouse chromosome 13 region A2 by in situ hybridization: identification of a new syntenic relationship.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488310393440
Pubmed

Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488315193432
Pubmed

Mouse Akr1cl gene product is a prostaglandin D2 11-ketoreductase with strict substrate specificity.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488331479646
Pubmed

Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488315222881
Pubmed

Isolation and characterization of a cDNA encoding mouse 3alpha-hydroxysteroid dehydrogenase: an androgen-inactivating enzyme selectively expressed in female tissues.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488316191478
Pubmed

Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488315577209
Pubmed

Identification of an interleukin-3-regulated aldoketo reductase gene in myeloid cells which may function in autocrine regulation of myelopoiesis.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488310702227
Pubmed

Crystal structures of mouse 17alpha-hydroxysteroid dehydrogenase (apoenzyme and enzyme-NADP(H) binary complex): identification of molecular determinants responsible for the unique 17alpha-reductive activity of this enzyme.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488317034817
Pubmed

Several distinct enzymes catalyze 20alpha-hydroxysteroid dehydrogenase activity in mouse liver and kidney.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488317629694
Pubmed

RECON-Dependent Inflammation in Hepatocytes Enhances Listeria monocytogenes Cell-to-Cell Spread.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488329764944
Pubmed

Cloning and characterization of two novel aldo-keto reductases (AKR1C12 and AKR1C13) from mouse stomach.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488310526179
Pubmed

Characterization of rat and mouse NAD+-dependent 3alpha/17beta/20alpha-hydroxysteroid dehydrogenases and identification of substrate specificity determinants by site-directed mutagenesis.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488317888864
Pubmed

Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488317442338
Pubmed

Sensing of Bacterial Cyclic Dinucleotides by the Oxidoreductase RECON Promotes NF-κB Activation and Shapes a Proinflammatory Antibacterial State.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488328329705
Pubmed

Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488316018803
Pubmed

Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488317272929
Pubmed

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488319237748
Pubmed

Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488318667791
Pubmed

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488328259989
Pubmed

Stereospecific reduction of 5β-reduced steroids by human ketosteroid reductases of the AKR (aldo-keto reductase) superfamily: role of AKR1C1-AKR1C4 in the metabolism of testosterone and progesterone via the 5β-reductase pathway.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488321521174
Pubmed

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C1 AKR1C2

6.25e-0848838274401
Pubmed

Crystallization and preliminary X-ray diffraction analysis of mouse 3(17)alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488316511129
Pubmed

Identification of the oxidative 3alpha-hydroxysteroid dehydrogenase activity of rat Leydig cells as type II retinol dehydrogenase.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488310803568
Pubmed

AKR1C1 alleviates LPS‑induced ALI in mice by activating the JAK2/STAT3 signaling pathway.

AKR1C3 AKR1C1 AKR1C2

6.25e-08488334590152
Pubmed

Localization of multiple human dihydrodiol dehydrogenase (DDH1 and DDH2) and chlordecone reductase (CHDR) genes in chromosome 10 by the polymerase chain reaction and fluorescence in situ hybridization.

AKR1C3 AKR1C1 AKR1C2

6.25e-0848837789999
Pubmed

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family.

AKR1C3 AKR1C1 AKR1C2

1.56e-0758837737980
Pubmed

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588321851338
Pubmed

Preterm birth without progesterone withdrawal in 15-hydroxyprostaglandin dehydrogenase hypomorphic mice.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588317872381
Pubmed

Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588317064890
Pubmed

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588310672042
Pubmed

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2α (PGF2α) levels.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588338788959
Pubmed

Expression of progesterone metabolizing enzyme genes (AKR1C1, AKR1C2, AKR1C3, SRD5A1, SRD5A2) is altered in human breast carcinoma.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588315212687
Pubmed

Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588316984997
Pubmed

Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice.

AKR1C3 AKR1C1 AKR1C2

1.56e-07588318003893
Pubmed

The Gαq/11-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688329107092
Pubmed

Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688319273550
Pubmed

Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688315860270
Pubmed

Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688315471942
Pubmed

MEF2 and NR2F2 cooperate to regulate Akr1c14 gene expression in mouse MA-10 Leydig cells.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688326748576
Pubmed

Adrenal 20alpha-hydroxysteroid dehydrogenase in the mouse catabolizes progesterone and 11-deoxycorticosterone and is restricted to the X-zone.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688317122075
Pubmed

Decidual prolactin silences the expression of genes detrimental to pregnancy.

AKR1C3 AKR1C1 AKR1C2

3.11e-07688317255200
Pubmed

The Steroidogenic Enzyme AKR1C3 Regulates Stability of the Ubiquitin Ligase Siah2 in Prostate Cancer Cells.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788326160177
Pubmed

Aldo-ketoreductase 1c19 ablation does not affect insulin secretion in murine islets.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788334843575
Pubmed

MicroRNA-200a serves a key role in the decline of progesterone receptor function leading to term and preterm labor.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788322529366
Pubmed

A phosphodiesterase 11 (Pde11a) knockout mouse expressed functional but reduced Pde11a: Phenotype and impact on adrenocortical function.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788333127481
Pubmed

Genetic variation in the progesterone receptor and metabolism pathways and hormone therapy in relation to breast cancer risk.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788319846565
Pubmed

A cluster of eight hydroxysteroid dehydrogenase genes belonging to the aldo-keto reductase supergene family on mouse chromosome 13.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788312562828
Pubmed

17Beta-HSD type 5 expression and the emergence of differentiated epithelial Type II cells in fetal lung: a novel role for androgen during the surge of surfactant.

AKR1C3 AKR1C1 AKR1C2

5.44e-07788316337335
Pubmed

Fetal onset of aberrant gene expression relevant to pulmonary carcinogenesis in lung adenocarcinoma development induced by in utero arsenic exposure.

CYP19A1 AKR1C3 AKR1C1 AKR1C2

6.42e-072788417077188
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

KIAA0930 KMT2D SPOUT1 VWA8 TXNRD3 PDCD11 EXOSC8 HERC2 FBXL19 ZZEF1 TOP3B ELAC2 DYNC1H1 RIC1

7.10e-071105881435748872
Pubmed

Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.

AKR1C3 AKR1C1 AKR1C2

8.69e-07888333584538
Pubmed

Naturally occurring variants of human aldo-keto reductases with reduced in vitro metabolism of daunorubicin and doxorubicin.

AKR1C3 AKR1C1 AKR1C2

8.69e-07888320837989
Pubmed

Cloning of mouse 17beta-hydroxysteroid dehydrogenase type 2, and analysing expression of the mRNAs for types 1, 2, 3, 4 and 5 in mouse embryos and adult tissues.

AKR1C3 AKR1C1 AKR1C2

8.69e-0788839224647
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

MET DNAJC13 L3MBTL2 VWA8 NSF CEBPZ DTNA N4BP2 SPTAN1 PDCD11 EXOSC8 UPF1 HERC2 DNAJA1 TOP3B ELAC2

9.08e-071487881633957083
Pubmed

Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models.

AKR1C3 AKR1C1 AKR1C2

1.30e-06988333348080
Pubmed

Lack of placental neurosteroid alters cortical development and female somatosensory function.

AKR1C3 AKR1C1 AKR1C2

1.85e-061088336313771
Pubmed

Endogenous biotin as a marker of adrenocortical cells with steroidogenic potential.

AKR1C3 AKR1C1 AKR1C2

3.39e-061288321256921
Pubmed

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1.

AKR1C3 AKR1C1 AKR1C2

3.39e-061288328893949
Pubmed

A Novel Population of Inner Cortical Cells in the Adrenal Gland That Displays Sexually Dimorphic Expression of Thyroid Hormone Receptor-β1.

AKR1C3 AKR1C1 AKR1C2

3.39e-061288325774556
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

DNAJC13 SPOUT1 UPF2 CEBPZ PDCD11 EXOSC8 ISG20L2 UPF1 HERC2 DNAJA1 TOP3B

3.46e-06759881135915203
Pubmed

The Diet1 locus confers protection against hypercholesterolemia through enhanced bile acid metabolism.

AKR1C3 AKR1C1 AKR1C2

4.40e-061388311682476
Pubmed

Genetic determinants modulate susceptibility to pregnancy-associated tumourigenesis in a recombinant line of Min mice.

AKR1C3 AKR1C1 AKR1C2

4.40e-061388317062636
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2D N4BP2 PROSER1

4.40e-061388317761849
Pubmed

A link between lung androgen metabolism and the emergence of mature epithelial type II cells.

AKR1C3 AKR1C1 AKR1C2

4.40e-061388315117747
Pubmed

Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.

AKR1C3 AKR1C1 AKR1C2

4.40e-061388324580729
Pubmed

Shh signaling regulates adrenocortical development and identifies progenitors of steroidogenic lineages.

AKR1C3 AKR1C1 AKR1C2

5.58e-061488319955443
Pubmed

Placental endocrine function shapes cerebellar development and social behavior.

AKR1C3 AKR1C1 AKR1C2

5.58e-061488334400844
Pubmed

Modulation of RNA-binding properties of the RNA helicase UPF1 by its activator UPF2.

UPF2 UPF1

6.33e-06288236456182
Pubmed

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells.

AKR1C1 AKR1C2

6.33e-0628828573067
Pubmed

Increased MACC1 expression indicates a poor prognosis independent of MET expression in gastric adenocarcinoma.

MET MACC1

6.33e-06288226719224
Pubmed

Structure of the human 3alpha-hydroxysteroid dehydrogenase type 3 in complex with testosterone and NADP at 1.25-A resolution.

AKR1C1 AKR1C2

6.33e-06288211514561
Pubmed

Selective loss of AKR1C1 and AKR1C2 in breast cancer and their potential effect on progesterone signaling.

AKR1C1 AKR1C2

6.33e-06288215492289
Pubmed

MACC1 controls Met: what a difference an Sp1 site makes.

MET MACC1

6.33e-06288219556890
Pubmed

Local androgen inactivation in abdominal visceral adipose tissue.

AKR1C3 AKR1C2

6.33e-06288214671194
Pubmed

MACC1 is related to colorectal cancer initiation and early-stage invasive growth.

MET MACC1

6.33e-06288224124150
Pubmed

MiR-1 downregulation cooperates with MACC1 in promoting MET overexpression in human colon cancer.

MET MACC1

6.33e-06288222179665
Pubmed

Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.

UPF2 UPF1

6.33e-06288219556969
Pubmed

Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy.

MET MACC1

6.33e-06288222493396
Pubmed

AKR1C1 and AKR1C3 may determine progesterone and estrogen ratios in endometrial cancer.

AKR1C3 AKR1C1

6.33e-06288216338060
Pubmed

Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers.

AKR1C3 AKR1C1

6.33e-06288223165153
Pubmed

Prognostic value and clinical pathology of MACC-1 and c-MET expression in gastric carcinoma.

MET MACC1

6.33e-06288223812675
Pubmed

AKR1C2 and AKR1C3 expression in adipose tissue: Association with body fat distribution and regulatory variants.

AKR1C3 AKR1C2

6.33e-06288233675863
Pubmed

Transcriptomic Profiling Reveals AKR1C1 and AKR1C3 Mediate Cisplatin Resistance in Signet Ring Cell Gastric Carcinoma via Autophagic Cell Death.

AKR1C3 AKR1C1

6.33e-06288234830394
Pubmed

Molecular mechanisms for the RNA-dependent ATPase activity of Upf1 and its regulation by Upf2.

UPF2 UPF1

6.33e-06288221419344
Pubmed

cDNA and deduced amino acid sequences of a human colon dihydrodiol dehydrogenase.

AKR1C1 AKR1C2

6.33e-0628828011662
Pubmed

Cadmium, cobalt and lead cause stress response, cell cycle deregulation and increased steroid as well as xenobiotic metabolism in primary normal human bronchial epithelial cells which is coordinated by at least nine transcription factors.

AKR1C1 AKR1C2

6.33e-06288218654764
Pubmed

Upregulation of AKR1C1 and AKR1C3 expression in OPSCC with integrated HPV16 and HPV-negative tumors is an indicator of poor prognosis.

AKR1C3 AKR1C1

6.33e-06288230367463
Pubmed

Modeling single nucleotide polymorphisms in the human AKR1C1 and AKR1C2 genes: implications for functional and genotyping analyses.

AKR1C1 AKR1C2

6.33e-06288221217827
InteractionAKR1C4 interactions

AKR1C3 AKR1C1 AKR1C2

4.28e-068873int:AKR1C4
InteractionLSM1 interactions

SPOUT1 UPF2 EXOSC8 DDX20 TOP3B ELAC2

6.56e-06106876int:LSM1
InteractionTOP3B interactions

KIAA0930 KMT2D SPOUT1 UPF2 VWA8 SPTAN1 TXNRD3 PDCD11 EXOSC8 DDX20 UPF1 HERC2 FBXL19 ZZEF1 DNAJA1 TOP3B ELAC2 DYNC1H1 RIC1

1.29e-0514708719int:TOP3B
InteractionAKR1C3 interactions

AKR1C3 HUNK AKR1C1 AKR1C2

1.92e-0537874int:AKR1C3
InteractionFOXL1 interactions

KMT2D NELFCD NSF BCOR MAP2K3 TOP3B DYNC1H1

2.24e-05196877int:FOXL1
InteractionDNA2 interactions

TARS3 DBF4 CTNNBL1 UPF1 TOP3B

2.34e-0579875int:DNA2
InteractionHDAC11 interactions

NELFCD CEBPZ PDCD11 DDX20 DNAJA1 BDH1

5.48e-05154876int:HDAC11
Cytoband10p15-p14

AKR1C3 AKR1C1 AKR1C2

1.36e-07688310p15-p14
GeneFamilyAldo-keto reductases

AKR1C3 AKR1C1 AKR1C2

1.78e-0515633399
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DTNA HERC2 ZZEF1

3.17e-051863391
GeneFamilyADAM metallopeptidases with thrombospondin type 1 motif

ADAMTS16 ADAMTS14

1.97e-031963250
CoexpressionCONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP

KIAA0930 ELL2 DTNA AKR1C3 TOP3B AKR1C1 DYNC1H1 PRDM2

1.34e-06239878M4716
CoexpressionWANG_IMMORTALIZED_BY_HOXA9_AND_MEIS1_UP

AKR1C3 AKR1C1 AKR1C2 B4GALT6

6.88e-0637874MM630
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HRN

CELF5 GLRA2 LRRTM4 ZSCAN9 PAPPA HUNK AKR1C1 AKR1C2

1.59e-05335878M39065
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

CELF5 GPRASP1 GPR158 N4BP2 GLRA2 ANKIB1 PAPPA SERINC5 GRM5 MAP2K3 AKR1C1 AKR1C2 PRDM2 TTLL7

1.59e-0511068714M39071
CoexpressionIRITANI_MAD1_TARGETS_UP

AKR1C3 AKR1C1 AKR1C2

2.32e-0517873MM826
CoexpressionSERVITJA_LIVER_HNF1A_TARGETS_DN

AFM AKR1C3 ALAS2 CADPS2 AKR1C1 AKR1C2

4.16e-05190876MM1311
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA2

CELF5 GPRASP1 LRRTM4 PAPPA GRM5 FKBP1B AKR1C1 AKR1C2 B4GALT6

5.21e-05513879M39069
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_TM4SF4_POS_PENK_POS_NEURON_CELL

CELF5 DTNA AKR1C1 AKR1C2 ELMO1

5.48e-05122875M45802
CoexpressionGSE27786_LIN_NEG_VS_NKTCELL_DN

KMT2D ADAMTS16 CTNNBL1 CYP2U1 BDH1 PRDM2

5.53e-05200876M4788
CoexpressionBILBAN_B_CLL_LPL_UP

NSF DIPK1A SERINC5 ELMO1

6.18e-0564874M19930
CoexpressionLIN_TUMOR_ESCAPE_FROM_IMMUNE_ATTACK

AKR1C3 AKR1C1 AKR1C2

6.80e-0524873MM766
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_C_DN

AKR1C3 AKR1C1 AKR1C2

7.71e-0525873MM480
CoexpressionGOLDRATH_IMMUNE_MEMORY

AKR1C3 AKR1C1 AKR1C2 SOS2

8.30e-0569874MM621
CoexpressionIVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM

MET AKR1C3 AKR1C1 AKR1C2 BICC1 TTLL7

1.14e-04228876MM1014
CoexpressionBYSTRYKH_HEMATOPOIESIS_STEM_CELL_SCP2_QTL_TRANS

AKR1C3 AKR1C1 AKR1C2

1.34e-0430873MM853
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA1

CELF5 GPRASP1 GLRA2 LRRTM4 PAPPA CADPS2 FKBP1B AKR1C1 AKR1C2

1.39e-04584879M39068
CoexpressionSHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM3

AKR1C3 AKR1C1 AKR1C2 B4GALT6

1.41e-0479874MM535
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 HUNK GRM5 AKR1C1 BICC1

1.71e-0618388692fbd83a9d13ee91065cbd479fb298f1fd564568
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 DTNA ADAMTS16 BICC1 TTLL7

2.20e-061918861cb02007adb344f17ef73d58890f91298c7cf5a1
ToppCellMesenchymal_cells-Osteo-CAR|Mesenchymal_cells / Lineage and Cell class

DIPK1A CYP2U1 PAPPA HUNK ELMO1

2.47e-05174885430e3cd61bc2a471959faa40e817aa4dd7d82d28
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

MET MACC1 HUNK CADPS2 BICC1

2.61e-0517688536f77d878a53b30465b0dea8333a3865dba75613
ToppCellCOVID-19-kidney-Epi_(Mes)|COVID-19 / Disease (COVID-19 only), tissue and cell type

MET ADAMTS16 HUNK GRM5 BICC1

2.75e-05178885544379f5a6145429762258d426b876bb36c112f5
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET LAMA1 SERINC5 HUNK BICC1

2.98e-051818859d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET LAMA1 SERINC5 HUNK BICC1

3.06e-05182885eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET HUNK GRM5 AKR1C2 BICC1

3.14e-05183885738e94b50c4c08c727d4eed0708dda08aa6891b4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET DTNA HUNK ADAMTS14 AKR1C1

3.14e-0518388583592c332b1e82673f993d37c7f480befdc3dcda
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 ADAMTS16 GRM5 AKR1C1 BICC1

3.40e-051868855c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 DTNA PAPPA BICC1 TTLL7

3.40e-05186885b87acc80b7baa41681e4ed11d5537b9fbf5832f5
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

DTNA AKR1C3 PAPPA AKR1C1 TTLL7

3.48e-05187885d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 HUNK GRM5 BICC1

3.57e-0518888563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellCOVID-19-kidney-CD-PC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MACC1 ADAMTS16 PAPPA HUNK BICC1

3.57e-051888858f9996c3f3b27efaaae8960a66af77412de9c7ef
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 DTNA BICC1 TTLL7

3.66e-051898853b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 ADAMTS16 PAPPA HUNK CADPS2

3.66e-05189885bfc76a72b600d641c8fe58346e5d8986c34f3981
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

MACC1 DTNA PAPPA BICC1 TTLL7

3.66e-051898850be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET DTNA LAMA1 HUNK BICC1

3.76e-051908851cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET DTNA LAMA1 HUNK BICC1

3.76e-0519088559bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

LRRTM4 AKR1C3 GRM5 AKR1C1 B4GALT6

3.76e-051908856c7e1086c0a274cd5527c3104106e372811c9905
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

MET MACC1 RASEF CADPS2 AKR1C1

3.76e-0519088551ca9ef4df3220487152fcf684147730637c7cc1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MET LAMA1 HUNK AKR1C1 BICC1

3.85e-05191885d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCellControl-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

MACC1 VWA8 AKR1C3 AKR1C1 AKR1C2

3.85e-05191885a7bb8aba9c59c037d995a77928cc7b4d5cbb82b9
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 GRM5 AKR1C1 BICC1

4.05e-05193885ffa1932da2979d7b63dbac32eb5788346a3f5b2a
ToppCellNS-critical-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MET ZNHIT6 CADPS2 AKR1C1 AKR1C2

4.15e-051948852172d951896265243d14996eacce5aab5e14e26e
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

GPRASP1 GPR158 NSF HERC2 GRM5

4.15e-051948858aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 GRM5 AKR1C1 AKR1C2 BICC1

4.15e-051948858ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellcritical-Epithelial-Secretory|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MET ZNHIT6 ELL2 AKR1C1 AKR1C2

4.36e-05196885dbf14f5851c2b779a8b35e820c4584ea9096e49d
ToppCellNS-moderate-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ZNHIT6 AKR1C3 CADPS2 AKR1C1 AKR1C2

4.36e-0519688547930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell(5)_Fibroblasts-(5)_Fibroblast-F|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

SPTAN1 ADAMTS16 AKR1C3 PSME2 AKR1C2

4.46e-05197885fbff2fb7a8142b88c9dc71aa10980f4350b7e081
ToppCell(5)_Fibroblasts-(5)_Fibroblast-D|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)

KIAA0930 AKR1C3 PAPPA DNAJA1 AKR1C1

4.57e-05198885fd14efd8e6c74a04bde985c08dc34217c0ef1bab
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 AKR1C3 AKR1C1 BICC1

4.57e-05198885be305d89d48c67ce922fa71aaf15e24d00c89ff6
ToppCellNS-moderate-d_16-33-Epithelial|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MACC1 DSTN AKR1C3 AKR1C1 AKR1C2

4.68e-05199885aa2b51940115c22768c0d7493b4b60d41df3f376
ToppCellmoderate-Epithelial|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

MACC1 DSTN AKR1C3 AKR1C1 AKR1C2

4.79e-05200885095783c9b75113ae350c2d5fb1195d71b41fa695
ToppCellNS-moderate-d_07-13-Epithelial|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

MACC1 DSTN AKR1C3 AKR1C1 AKR1C2

4.79e-0520088585940b4bf7971b872469dea8b8d7a45bdeb2a909
ToppCellSevere-Epithelial-Epithelial-|Severe / Condition, Lineage, Cell class and cell subclass

MET MACC1 RASEF AKR1C1 AKR1C2

4.79e-052008858669ce08f93eefb8ac970e30cdc4b1f908023c54
ToppCellSevere-Epithelial|Severe / Condition, Lineage, Cell class and cell subclass

MET MACC1 RASEF AKR1C1 AKR1C2

4.79e-052008856ead9db88568bb829d564a6d8e85f71fd765bac0
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Neuronal|5w / Sample Type, Dataset, Time_group, and Cell type.

CELF5 FKBP1B AKR1C1 AKR1C2 DYNC1H1

4.79e-052008859b5753726c17dda98d7384a60f26a5eaf4f6c4d6
ToppCellSevere-Epithelial-Epithelial|Severe / Condition, Lineage, Cell class and cell subclass

MET MACC1 RASEF AKR1C1 AKR1C2

4.79e-052008853bd1ce2793651c9badd69f011d2531183594e5f4
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital|World / Primary Cells by Cluster

DSTN SPTAN1 FKBP1B DYNC1H1 TTLL7

4.79e-052008856bbe8e1f3e91678f1bfb14945365c1578a59a604
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Upper_Layer_Occipital-19|World / Primary Cells by Cluster

DSTN SPTAN1 FKBP1B DYNC1H1 TTLL7

4.79e-05200885c831d9e0a7178e3634da45548f91fa9e8dc6557c
ToppCell(01)_Cycling_Basal_(homeostasis)-(4)_1wkpi|(01)_Cycling_Basal_(homeostasis) / shred by cell type and Timepoint

CYP19A1 GLRA2 ADAMTS14 BICC1

1.01e-04122884b2a070939c0660c82a1130ef423fd627e9e087ab
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRTM4 ADAMTS16 ADAMTS14 GRM5

1.71e-041408847ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRRTM4 ADAMTS16 ADAMTS14 GRM5

1.71e-041408841a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCellpdx-Tumor_cells-T9|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KMT2D SPTAN1 MAP2K3 DYNC1H1

1.90e-041448840b94d978262a826c9254145aa98c6c30240243f9
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-5|TCGA-Endometrium / Sample_Type by Project: Shred V9

GPR158 DTNA ADAMTS16 WDR53

2.65e-0415788459450e9f580555091b159fbbe0a0756e51bcd9ad
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

UPF1 ADAMTS14 FBXL19

3.03e-046688357fd31a25addc48793d7975eadccf4c5a41a8b03
ToppCell10x5'-Lung-Lymphocytic_T_CD8-Tnaive/CM_CD8|Lung / Manually curated celltypes from each tissue

CELF5 TRBV23-1 TXNRD3 LINC02901

3.06e-04163884c8e4440d1a857e4da83002303940dd42b273c92e
ToppCellfacs-Lung-ENDOMUCIN-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 DNAJC13 FKBP1B BDH1

3.13e-0416488454f8f11d2fa899005530c08e7a1ee728c7b0799c
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

MACC1 UPF2 ZNF285 PRDM2

3.27e-041668848de8f388f24436b84e19ef460476fdbda4d16abf
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MET AFM LRRTM4 AKR1C1

3.27e-041668849e98e6070055bfc780becee52d77830e06b6d854
ToppCell356C-Myeloid-Macrophage-SPP1+_Macrophage_4|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

OSGEPL1 DIPK1A TXNRD3 LINC02901

3.27e-041668848d5d09f25e8903d481c2097fed435e69d42ccdb5
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 DTNA ADAMTS16 RASEF

3.35e-04167884cf6206c506715cd846799c62cf7c06e3fa99f7af
ToppCellTCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Spindle_Cell-1|TCGA-Uvea / Sample_Type by Project: Shred V9

KIAA0930 SPOUT1 SPTAN1 CTNNBL1

3.43e-04168884b427746929bb40e3d1b5f1c40d302b792d6b32a5
ToppCellCOVID-19-kidney-PEC|COVID-19 / Disease (COVID-19 only), tissue and cell type

MET ADAMTS16 GRM5 BICC1

3.43e-04168884a086c306be430adf0632ba53e98cd8014d2de330
ToppCelldroplet-Liver-LIVER_HEPATOCYTES-30m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MACC1 DTNA ADAMTS16 RASEF

3.50e-0416988430141f76e9bfc2b4586429857c72dbc85ba65cc9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET SERINC5 HUNK AKR1C1

3.58e-041708845d5f208682be21ed58320f5fc083a7898f8712da
ToppCellfacs-Heart-LV-3m-Endothelial-endothelial_cell_of_endocardium|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

N4BP2 TXNRD3 RASEF HUNK

3.75e-04172884f2c17c49b375b28ad47dc6cabda62f1c238023dd
ToppCellfacs-Heart-LV-3m-Endothelial-endocardial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

N4BP2 TXNRD3 RASEF HUNK

3.75e-041728846ab4f01098dddb789df298ddf97b3c384405ee6c
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

NEUROD4 CYP19A1 LRRTM4 PAPPA

3.83e-041738846fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Degenerative_Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET DTNA HUNK AKR1C1

3.91e-0417488446bd0ef7d0541386de7a901d85d53d0176dc92bf
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

MET MACC1 ADAMTS16 BICC1

4.08e-041768840923b01137d6f9956ca815b41102c81e82624065
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

L3MBTL2 ISG20L2 DDX20 BDH1

4.08e-0417688491ad2c34144f72283ca112fd3b3784f2f6259f65
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

HUNK GRM5 AKR1C2 BICC1

4.08e-04176884327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 HUNK AKR1C2 BICC1

4.17e-04177884da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCellLPS-IL1RA+antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ISG20L2 DDX20 DNAJA1 AKR1C1

4.17e-041778842dd6dd5193bda9ba1c6b299ec47890fdc92f88b1
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma|TCGA-Brain / Sample_Type by Project: Shred V9

TARS3 UPF2 SPTAN1 DYNC1H1

4.17e-04177884e8ab340b20cd41554c3841fe980e078e878af35f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET HUNK ADAMTS14 AKR1C1

4.35e-0417988455bc69f107fc710db7617c428575792adfdbbcc1
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

VWA8 LAMA1 CADPS2 B4GALT6

4.45e-041808849e09b3dfe344b5d50520711513d389865d73a861
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

MET MACC1 PAPPA BICC1

4.45e-04180884358923e4228035a3e90e2957392089219e90dcd7
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA HUNK CADPS2

4.45e-04180884023ec0b080c8a5cd0f36e83c6b17d4be3c01edb5
ToppCellRA-01._Fibroblast_I|World / Chamber and Cluster_Paper

PAPPA AKR1C1 AKR1C2 BICC1

4.54e-041818842b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 HUNK AKR1C2 BICC1

4.54e-04181884071f9bb5d39070cdc473d9b0e094d196bc702b56
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 HUNK GRM5 BICC1

4.54e-041818846956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNHIT6 DSTN CYP2U1 PRKCG

4.63e-04182884dfde2d9950f445c6c936ac828f7210de87bb45ec
ToppCell343B-Lymphocytic-NK_cells-NK_cell_D|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

AKR1C3 UPF1 ADAMTS14 FBXL19

4.63e-04182884c6172aca2475bf0948a78e39f0dae6388504a915
ToppCell5'-GW_trimst-1-SmallIntestine-Mesenchymal-myocytic|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZNHIT6 DSTN CYP2U1 PRKCG

4.63e-0418288452274af3136d4fd4a495f5882618444661421f0f
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MET LRRTM4 PAPPA BICC1

4.73e-041838847eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam_____kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFM CADPS2 TOP3B BDH1

4.73e-04183884f3728b1a51951c7349f77a3e4d2671ca3a8d2a44
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

SERINC5 HUNK AKR1C1 BICC1

4.83e-04184884da06ff24ee2b2cf4715fdfce43030b2da9e0aaf8
ToppCell368C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0|368C / Donor, Lineage, Cell class and subclass (all cells)

TARS3 AKR1C3 TOP3B BDH1

4.83e-04184884d48807f9da48bdd015a54c606d2e2a311f181396
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-kidney_distal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFM CADPS2 TOP3B BDH1

4.83e-041848848939b6d795992775df0ff58ed1ec9d421a00bcc4
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DTNA LRRTM4 PAPPA CCDC171

4.93e-041858846712512100ccef456d2e2bd201d0987986c92ac9
ToppCellControl-Myeloid-Macrophage_Alveolar|World / Disease state, Lineage and Cell class

MACC1 AKR1C3 AKR1C1 AKR1C2

4.93e-0418588485cb81759589a26d83676cffbf2bc37399683c10
ToppCellkidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA HUNK CADPS2

5.03e-04186884aeac0c2db173cd1ea45b5052ab418d6cacd198d8
ToppCellCOPD-Epithelial-Goblet|World / Disease state, Lineage and Cell class

MET RASEF AKR1C1 AKR1C2

5.03e-04186884d75fe7640a4b2c450c9759a1b3c3ef2a087f0092
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MET MACC1 DTNA BICC1

5.03e-04186884f28d72b47624b69a580b4429e2be560a26898591
ToppCelldroplet-Marrow-BM-30m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MET KIAA0930 DIPK1A FKBP1B

5.03e-04186884bcb3ac9f9b51346e0a2b0bda96d149b3c11f7883
ToppCelldroplet-Marrow-BM-1m-Myeloid-promonocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MET DIPK1A EXOSC8 FKBP1B

5.13e-04187884028e7d6e1211e123879d2f353dc32fae1185dd8e
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA BICC1 TTLL7

5.13e-041878849d77ca45f7563bd6f2a0c1be5d99d93ad30983f7
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MET LAMA1 HUNK BICC1

5.13e-04187884c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA HUNK CADPS2

5.13e-04187884e3095455d2f255854f339f6b05fa87852af0700f
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MET MACC1 RASEF AKR1C1

5.24e-0418888443a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)|Striatum / BrainAtlas - Mouse McCarroll V32

CELF5 UPF2 PRKCG GRM5

5.24e-04188884e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA HUNK CADPS2

5.24e-04188884e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA HUNK CADPS2

5.34e-041898843a295c215b5c18e7c673f92b7af5be523421682c
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HUNK GRM5 AKR1C1 BICC1

5.34e-04189884904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LAMA1 AKR1C3 AKR1C1 AKR1C2

5.34e-041898840739baad9a7da511dd3d7249f84299aee88370a1
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADAMTS16 HUNK CADPS2 BICC1

5.34e-0418988490aae7e806882bebfad78a78e9a16cf56af3ecd4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 PAPPA HUNK CADPS2

5.34e-04189884fc88c51ace7d883c01617f3f9b5fab70cc91cc09
Drugcyclopentanol

AKR1C3 AKR1C1 AKR1C2

5.20e-083863ctd:C016327
Drugcyclopentanone

AKR1C3 AKR1C1 AKR1C2

5.20e-083863ctd:C007201
Drug4-benzoylbenzoic acid

AKR1C3 AKR1C1 AKR1C2

5.20e-083863ctd:C058818
Drugdichloro(4-cymene)ruthenium(II)

AKR1C3 AKR1C1 AKR1C2

5.20e-083863ctd:C530610
Drugcloxazolam

AKR1C3 AKR1C1 AKR1C2

2.08e-074863ctd:C005522
DrugPregnanes

AKR1C3 AKR1C1 AKR1C2

2.08e-074863ctd:D011278
Drugtetralol

AKR1C3 AKR1C1 AKR1C2

2.08e-074863ctd:C019106
Druggliquidone

AKR1C3 AKR1C1 AKR1C2

2.08e-074863ctd:C010969
Drug3',3'',5',5''-tetrabromophenolphthalein

AKR1C3 AKR1C1 AKR1C2

2.08e-074863ctd:C018156
DrugHydroxysteroids

AKR1C3 AKR1C1 AKR1C2

5.17e-075863ctd:D006914
DrugNSC86000

AKR1C3 AKR1C1 AKR1C2

5.17e-075863CID000257630
Drugcresolphthalein

AKR1C3 AKR1C1 AKR1C2

5.17e-075863ctd:C010092
Drugoxcarbazepine

CYP19A1 AKR1C3 AKR1C1 AKR1C2

7.04e-0719864ctd:C036006
DrugEstazolam

AKR1C3 AKR1C1 AKR1C2

1.03e-066863ctd:D004949
DrugGlipizide

AKR1C3 AKR1C1 AKR1C2

1.03e-066863ctd:D005913
Drugacenaphthene-1-ol

AKR1C3 AKR1C1 AKR1C2

1.03e-066863ctd:C023723
DrugMedazepam

AKR1C3 AKR1C1 AKR1C2

1.03e-066863ctd:D008472
Drugandrostane-3,17-dione

DTNA CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.40e-0651865CID000000443
Drug4-hydroxyequilenin-o-quinone

AKR1C3 AKR1C1 AKR1C2

1.80e-067863ctd:C117714
Drugzomepirac

AKR1C3 AKR1C1 AKR1C2

1.80e-067863ctd:C020549
Drug1,2-dihydroxynaphthalene

CYP19A1 CTNNBL1 AKR1C3 AKR1C1 AKR1C2

2.45e-0657865CID000011318
DrugNitrazepam

AKR1C3 AKR1C1 AKR1C2

2.87e-068863ctd:D009567
DrugUDP-FGlc

UPF2 UPF1 GRM5 BDH1 B4GALT6

3.73e-0662865CID000125643
Drug4-hydroxybenzoic acid

AKR1C3 AKR1C1 AKR1C2

4.30e-069863ctd:C038193
Drug20-alpha-Dihydroprogesterone

AKR1C3 AKR1C1 AKR1C2

4.30e-069863ctd:D004092
Drugoctyl gallate

AKR1C3 AKR1C1 AKR1C2

6.13e-0610863ctd:C016627
DrugDihydroxydihydrobenzopyrenes

AKR1C3 AKR1C1 AKR1C2

8.40e-0611863ctd:D004101
Drug7-hydroxyflavone

CYP19A1 AKR1C3 AKR1C1

8.40e-0611863ctd:C429845
Drugchlordecone alcohol

AKR1C3 AKR1C1 AKR1C2

8.40e-0611863CID000013946
Drugindomethacin, USP; Down 200; 100uM; MCF7; HG-U133A

GPRASP1 KIAA0930 DTNA ZBTB40 CADPS2 ZZEF1 SOS2

1.02e-05198867453_DN
Drugfenamic acid

AKR1C3 AKR1C1 AKR1C2

1.12e-0512863ctd:C001209
DrugPhenolphthalein

AKR1C3 AKR1C1 AKR1C2

1.12e-0512863ctd:D020113
Drugalpha-methylcinnamic acid

AKR1C3 AKR1C1

1.41e-052862ctd:C510582
Drug(10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE

AKR1C1 AKR1C2

1.41e-052862DB07768
Drugbaccharin

AKR1C3 AKR1C2

1.41e-052862ctd:C012764
DrugDMBA-3,4-dihydrodiol

AKR1C3 AKR1C1 AKR1C2

1.45e-0513863CID000050096
Drugflunisolide

AKR1C3 AKR1C1 AKR1C2

1.45e-0513863ctd:C007734
Drug20 alpha-dihydroprogesterone

CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.56e-0540864CID000008956
DrugDydrogesterone

AKR1C3 AKR1C1 AKR1C2

1.84e-0514863ctd:D004394
Drug5-alpha-Dihydroprogesterone

AKR1C3 AKR1C1 AKR1C2

1.84e-0514863ctd:D043582
Drug1-acenaphthenol

AKR1C3 AKR1C1 AKR1C2

1.84e-0514863CID000022750
DrugMeclofenamic Acid

AKR1C3 AKR1C1 AKR1C2

1.84e-0514863ctd:D008469
Drugnaphthalene-1,2-dihydrodiol

CYP19A1 AKR1C3 AKR1C1 AKR1C2

2.51e-0545864CID000000362
Drugphorbol 12,13-diacetate

NSF CYP19A1 PRKCG GRM5

3.25e-0548864CID000072293
Drugbenzo(a)pyrene-1,6-quinone

AKR1C3 AKR1C1 AKR1C2

3.41e-0517863ctd:C030233
Drugcloxazolam

AKR1C3 AKR1C1 AKR1C2

4.08e-0518863CID000002816
DrugRuthenium Compounds

AKR1C3 AKR1C1 AKR1C2

4.08e-0518863ctd:D017975
Drugbenzo(a)pyrene-3,6-quinone

AKR1C3 AKR1C1 AKR1C2

4.08e-0518863ctd:C018003
DrugMoF4

UPF2 UPF1

4.22e-053862CID000141030
Drug5-dihydrodeoxycorticosterone

AKR1C1 AKR1C2

4.22e-053862ctd:C454687
Drugbenzo(a)pyrene-7,8-dione

AKR1C3 AKR1C1 AKR1C2

5.66e-0520863ctd:C076588
DrugChrysenes

AKR1C3 AKR1C1 AKR1C2

5.66e-0520863ctd:D002911
DrugFlunitrazepam

AKR1C3 AKR1C1 AKR1C2

6.59e-0521863ctd:D005445
Drugconiferaldehyde

AKR1C3 AKR1C1 AKR1C2

6.59e-0521863ctd:C075384
DrugDutasteride

AKR1C3 AKR1C1 AKR1C2

6.59e-0521863ctd:D000068538
DrugNSC36919

CYP19A1 AKR1C3 AKR1C1 AKR1C2

6.89e-0558864CID000235496
Drugbenzene dihydrodiol

AKR1C3 AKR1C1 AKR1C2

7.61e-0522863CID000000418
Drugtetrahydrodeoxycorticosterone

AKR1C1 AKR1C2

8.42e-054862ctd:C009413
DrugDBD-H

AKR1C3 AKR1C1

8.42e-054862CID000131382
Drugthapsigargin; Down 200; 0.1uM; MCF7; HT_HG-U133A

SPOUT1 OSGEPL1 DIPK1A AKR1C3 DNAJA1 SOS2

8.43e-051908667053_DN
Drug2'-Monophosphoadenosine 5'-Diphosphoribose

AKR1C3 AKR1C1 AKR1C2

8.72e-0523863DB03461
Drugmedazepam

AKR1C3 AKR1C1 AKR1C2

9.94e-0524863CID000004041
Drug1-chloro-1,2,2-trifluorocyclobutane

GLRA2 PRKCG GRM5

9.94e-0524863CID000079091
DrugGlycyrrhetinic Acid

AKR1C3 AKR1C1 AKR1C2

9.94e-0524863ctd:D006034
DrugMyricetin [529-44-2]; Up 200; 12.6uM; MCF7; HT_HG-U133A

DTNA CTNNBL1 AKR1C3 TOP3B DYNC1H1 SOS2

1.06e-041988663270_UP
Drugclofibrate; Up 200; 100uM; MCF7; HG-U133A

MET OSGEPL1 DTNA NEUROD4 ZBTB40 SOS2

1.09e-04199866444_UP
Drug9,10-phenanthrenequinone

AKR1C3 AKR1C1 AKR1C2

1.13e-0425863ctd:C005399
DrugPregnanolone

AKR1C3 AKR1C1 AKR1C2

1.13e-0425863ctd:D011280
DrugPEt3

NSF LAMA1 UPF1

1.27e-0426863CID000027365
Drugfarnesal

AKR1C3 AKR1C2

1.40e-045862ctd:C084519
Drugdienogest

CYP19A1 AKR1C1 AKR1C2

1.43e-0427863ctd:C023635
Drug5 beta-pregnane-3,20-dione

CYP19A1 AKR1C3 AKR1C1 AKR1C2

1.60e-0472864CID000092745
DrugAC1L93E5

AKR1C3 AKR1C1

2.09e-046862CID000412383
Drug3-hydroxyhexobarbital

AKR1C3 AKR1C2

2.09e-046862CID000439898
DrugAC1O43OJ

TXNRD3 AKR1C2

2.09e-046862CID006323224
Drugpivalaldehyde

DTNA CYP19A1

2.09e-046862CID000012417
Drugbenzo(a)pyrene 7,8-dihydrodiol

AKR1C3 AKR1C1 AKR1C2

2.17e-0431863ctd:C017228
DrugNAD

AKR1C3 AKR1C1 AKR1C2 BDH1

2.41e-0480864ctd:D009243
DrugNSC759587

NSF CYP19A1 SPTAN1 GLRA2 PRKCG SERINC5 GRM5 PRDM2

2.76e-04444868CID000003816
Drugestazolam

AKR1C3 AKR1C1 AKR1C2

3.12e-0435863CID000003261
DiseaseNeoplasms, Hormone-Dependent

AKR1C3 AKR1C1 AKR1C2

2.23e-083843C0027661
DiseaseAmbiguous Genitalia

AKR1C3 AKR1C1 AKR1C2

2.22e-075843C0266362
DiseasePseudohermaphroditism

AKR1C3 AKR1C1 AKR1C2

2.22e-075843C0033804
DiseaseHermaphroditism

AKR1C3 AKR1C1 AKR1C2

2.22e-075843C0019269
DiseaseIntersex Conditions

AKR1C3 AKR1C1 AKR1C2

2.22e-075843C2930618
DiseaseSex Differentiation Disorders

AKR1C3 AKR1C1 AKR1C2

2.22e-075843C2930619
DiseaseDisorders of Sex Development

AKR1C3 AKR1C1 AKR1C2

7.73e-077843C0036875
DiseaseEndometrioma

CYP19A1 AKR1C3 PAPPA AKR1C1 AKR1C2

9.91e-05161845C0269102
DiseaseEndometriosis

CYP19A1 AKR1C3 PAPPA AKR1C1 AKR1C2

9.91e-05161845C0014175
Diseasecortolone glucuronide (1) measurement

AKR1C3 AKR1C2

1.19e-046842EFO_0800552
Diseasefunctional impairment measurement

ADAMTS16 ZZEF1

1.67e-047842EFO_0005412
Diseasehair colour measurement, eye colour measurement, skin pigmentation measurement

HERC2 GRM5

3.55e-0410842EFO_0007009, EFO_0007822, EFO_0009764
DiseaseMental Retardation, Psychosocial

LAMA1 ZBTB40 PRKCG DYNC1H1

6.80e-04139844C0025363
DiseaseProfound Mental Retardation

LAMA1 ZBTB40 PRKCG DYNC1H1

6.80e-04139844C0020796
DiseaseMental deficiency

LAMA1 ZBTB40 PRKCG DYNC1H1

6.80e-04139844C0917816
Diseaseserum IgG glycosylation measurement

ELL2 GPR158 NEUROD4 LRRTM4 HUNK ELMO1 SOS2

7.37e-04523847EFO_0005193
DiseaseSclerocystic Ovaries

CYP19A1 AKR1C3 AKR1C1 AKR1C2

7.76e-04144844C1136382
DiseasePolycystic Ovary Syndrome

CYP19A1 AKR1C3 AKR1C1 AKR1C2

7.76e-04144844C0032460
Diseaseresponse to methotrexate

AKR1C1 AKR1C2

9.36e-0416842GO_0031427
Diseaseskin pigmentation

CFHR2 HERC2 CADPS2

1.02e-0369843EFO_0003784
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

CYP19A1 AKR1C3

1.62e-0321842DOID:11612 (biomarker_via_orthology)
Diseasetotal blood protein measurement

DNAJC13 KMT2D ELL2 DIPK1A CYP19A1 FBXL19

1.80e-03449846EFO_0004536
Diseasehair colour measurement

KIAA0930 KMT2D CTNNBL1 SERINC5 HERC2 GRM5 CCDC171

1.87e-03615847EFO_0007822
DiseaseHereditary Paraganglioma-Pheochromocytoma Syndrome

MET KMT2D

1.95e-0323842C1708353
DiseasePeriodontal Pocket

ADAMTS14 ELMO1

2.30e-0325842EFO_1001393
Diseasemajor depressive disorder, COVID-19

NSF GRM5

2.49e-0326842MONDO_0002009, MONDO_0100096
Diseasesunburn

KIAA0930 HERC2 GRM5

2.63e-0396843EFO_0003958

Protein segments in the cluster

PeptideGeneStartEntry
GSVLLKCPKPMEENH

ELL2

441

O00472
VVTGKDCPHMKEKGA

ELMO1

616

Q92556
MIGPEGTDNCHKFVD

CTNNBL1

361

Q8WYA6
TVKHEQKMDCGGGYI

CALR3

96

Q96L12
MFGPDICGFDIKKVH

CALR3

131

Q96L12
LVFAGCLMKDKGHDG

BDH1

81

Q02338
QCVKLNDGHFMPVLG

AKR1C3

6

P42330
EKICAMEGLPQKHNF

AFM

96

P43652
GMLVCTGEPQDKHKF

CCDC171

836

Q6TFL3
GMKACVELLVKHGGD

ANKIB1

156

Q9P2G1
KMEGLECHVFIGGTP

DDX20

156

Q9UHI6
DPFKHFVGMLPEKDC

DSTN

66

P60981
KHGDIKCVLNEGMPI

DNAJA1

296

P31689
REGGHPATKDSEMCK

BCOR

1031

Q6W2J9
GGNNIKKVMEETGCH

BICC1

151

Q9H694
KKVMEETGCHIHFPD

BICC1

156

Q9H694
CDFKNMDSLPSGKIH

DBF4

561

Q9UBU7
NGTHKVMPAKACAGD

ADAMTS14

941

Q8WXS8
ETKFMPAAEGTICGH

ADAMTS16

551

Q8TE57
ICNEIVHPGCLKMGK

FBXL19

116

Q6PCT2
GQKCVPGHFGEKLAM

RASEF

666

Q8IZ41
MKGTPHFKEEQCAPA

RIC1

116

Q4ADV7
MDEEGKLCCLHKPGG

EXOSC8

226

Q96B26
IKHPECSTMSGGKAI

OSGEPL1

211

Q9H4B0
HKSEIECFTPKGSMG

GRM5

886

P41594
GNKESTMICAGPKHI

LRRTM4

331

Q86VH4
TMICAGPKHIQGEKV

LRRTM4

336

Q86VH4
EKNLPEFAKMVCHGE

NELFCD

221

Q8IXH7
CPNHGFKVGMKLEAV

L3MBTL2

531

Q969R5
HLNNSECMPIKGLGF

GPR158

331

Q5T848
DGKLGHFSRMNCDKP

HERC2

3076

O95714
EFVRMKGPQGKGHAE

KIAA0930

241

Q6ICG6
RGMKNEEHCPGSFFL

LINC02901

76

Q4VX62
VGGEAMFCDFPKINH

CFHR2

16

P36980
AIDCEMVGTGPKGHV

ISG20L2

181

Q9H9L3
EQMGCKHVKGILLYG

NSF

246

P46459
EGHIKITDFGMCKEN

PRKCG

491

P05129
PAFVKKQHNGVCDMD

PAPPA

446

Q13219
AKGHCPFMLSELQDG

ALAS2

66

P22557
HTVQPKGKITFCMGI

PIPSL

561

A2A3N6
LEQAFKGGCKAPHAM

PROSER1

121

Q86XN7
VGDHCQLGPVVMCKK

UPF1

671

Q92900
VKAEMQKHGEDPFCP

CYP2U1

206

Q7Z449
GCGEMPRHFAAKLDK

B4GALT6

241

Q9UBX8
FGSKLGLQCIGMHEK

CYP19A1

116

P11511
FPKKGQTCVVHYTGM

FKBP1B

16

P68106
EGKICHGGIDPAFAM

GUCY2F

456

P51841
VLKDPYTGMHKGCAF

CELF5

76

Q8N6W0
ELCPGGNLMHKIYEK

HUNK

141

P57058
KFVGQCIKEELMHGE

ZNHIT6

166

Q9NWK9
QKHGMDEFISANPCK

CADPS2

626

Q86UW7
GNRDVCVKMTPTHKG

DNAJC13

326

O75165
TEMVCLHSLGKEGPF

MACC1

306

Q6ZN28
GMGHCLQVKDGTAVK

GLRA2

376

P23416
PEGHGKISVFAVKMA

DTNA

121

Q9Y4J8
CKVDGHKDIQMPDGI

DYNC1H1

4286

Q14204
DKEHTPKLMGFCGDL

DIPK1A

211

Q5T7M9
PGHGSFVNCGMKKEV

SPOUT1

201

Q5T280
CKHPNMKGVVSGEVE

CEBPZ

411

Q03701
TKCGKGVDNMPELHK

PRDM2

1336

Q13029
MIKGGGLKHVPCVED

UPF2

1096

Q9HAU5
VLINKEGHVKMCDFG

MAP2K3

196

P46734
PKEAASLFCEMFGGK

GPRASP1

1071

Q5JY77
TLKCTVGPAMNKHFN

MET

621

P08581
EKDTFALKPMNCPGH

TARS3

481

A2RTX5
LFDGLMISCKPNHGQ

SOS2

461

Q07890
CGEKGPEMFCKLVEH

LAMA1

41

P25391
KEVHKCGFLPGNEKV

PSME2

86

Q9UL46
FAFLHCKKLVENGGM

SUPT5H

621

O00267
QCVKLNDGHFMPVLG

AKR1C1

6

Q04828
QCVKLNDGHFMPVLG

AKR1C2

6

P52895
DAVLPVMNKAHGGEK

TOP3B

131

O95985
GVVDFMHLDPKKAGT

PDCD11

306

Q14690
EKVGVAFDHMKVCFG

ELAC2

741

Q9BQ52
CVSHMKPYVDGKGRE

SPTAN1

2441

Q13813
IPFFEDMCKGIKAGD

SERINC5

66

Q86VE9
VMGVKCEQELGFKGH

WDR53

226

Q7Z5U6
QKTKMDCTPEKGHTF

TRBV23-1

36

A0A0A0MS06
KGHQRILMGEKPYEC

ZNF658

506

Q5TYW1
QLVGDCLMKAHQGKG

ZZEF1

1941

O43149
GTCVNVGCIPKKLMH

TXNRD3

201

Q86VQ6
CPKIVEPHGKMFNEQ

ZSCAN9

206

O15535
QSHMVKDICLIGGKG

VWA8

436

A3KMH1
HPSCGKNLGMKSTVE

ZNF285

206

Q96NJ3
NHFPGMGEICRKDFL

TTLL7

96

Q6ZT98
LHECGKCGKAFMPQL

ZNF175

306

Q9Y473
KEMIVKCFEGEGGHS

ZBTB40

276

Q9NUA8
KGHQRILMGEKPYEC

ZNF658B

266

Q4V348
LKGEGGVEHMECEIK

KMT2D

1651

O14686
VSCGKFMQDPSLVGH

N4BP2

1436

Q86UW6
GQTPEGKGFVEMLCK

NEUROD4

146

Q9HD90