Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	calcium-dependent cysteine-type endopeptidase activity	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	8.30e-09	17	87	5	GO:0004198
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 OR11H7 FFAR1 ADGRE3 TAS1R1 OR4Q3 OR2T10 ADGRE2 OR6M1 ADGRL3	5.83e-06	884	87	15	GO:0004930
GeneOntologyMolecularFunction	cysteine-type endopeptidase activity	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	3.69e-05	86	87	5	GO:0004197
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR2C1 FLT4 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 OR11H7 FFAR1 ADGRE3 TAS1R1 OR4Q3 CLDN3 OR2T10 ADGRE2 OR6M1 ADGRL3	6.42e-05	1353	87	17	GO:0004888
GeneOntologyMolecularFunction	peptidase activity	CAPN8 CAPN1 CAPN2 CAPN3 ENDOU PLAT CPE PSMB11 PRSS36 CAPN11	5.48e-04	654	87	10	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	CAPN8 CAPN1 CAPN2 CAPN3 PLAT PSMB11 PRSS36 CAPN11	5.73e-04	430	87	8	GO:0004175
GeneOntologyMolecularFunction	alcohol binding	GPR155 PRKCE CYP2W1 XPR1	1.03e-03	102	87	4	GO:0043178
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 GUCY2F OR11H7 FFAR1 ADGRE3 AGT TAS1R1 OR4Q3 CPE OR2T10 ADGRE2 OR6M1 ADGRL3 NMU	7.42e-06	1395	90	19	GO:0007186
GeneOntologyBiologicalProcess	sensory perception	OR2C1 OR4S1 TMTC4 MYO7B OR2AP1 ASIC1 GUCY2F OR11H7 ESPNL UGT2A1 TAS1R1 OR4Q3 OR2T10 PKHD1L1 OR6M1 NMU	1.44e-05	1072	90	16	GO:0007600
GeneOntologyBiologicalProcess	calcium-dependent self proteolysis	CAPN8 CAPN3	1.88e-05	2	90	2	GO:1990092
GeneOntologyBiologicalProcess	self proteolysis	CAPN8 CAPN1 CAPN3	3.52e-05	15	90	3	GO:0097264
GeneOntologyBiologicalProcess	tight junction assembly	CLDN25 ILDR1 CLDN5 CLDN15 CLDN3	4.16e-05	88	90	5	GO:0120192
GeneOntologyBiologicalProcess	cellular response to prostaglandin E stimulus	P2RY4 PRKAA2 PRKCE	4.32e-05	16	90	3	GO:0071380
GeneOntologyBiologicalProcess	tight junction organization	CLDN25 ILDR1 CLDN5 CLDN15 CLDN3	5.72e-05	94	90	5	GO:0120193
GeneOntologyBiologicalProcess	response to alcohol	GPR155 P2RY4 CYP7A1 PRKAA2 PRKCE SDF4 CLDN5 CLDN3	6.63e-05	312	90	8	GO:0097305
GeneOntologyBiologicalProcess	cell-cell junction assembly	AGT CLDN25 ILDR1 CLDN5 CLDN15 CLDN3	9.14e-05	167	90	6	GO:0007043
GeneOntologyBiologicalProcess	cellular response to prostaglandin stimulus	P2RY4 PRKAA2 PRKCE	1.34e-04	23	90	3	GO:0071379
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR2C1 OR4S1 OR2AP1 ASIC1 OR11H7 UGT2A1 TAS1R1 OR4Q3 OR2T10 OR6M1	1.35e-04	547	90	10	GO:0007606
GeneOntologyBiologicalProcess	response to prostaglandin E	P2RY4 PRKAA2 PRKCE	1.94e-04	26	90	3	GO:0034695
GeneOntologyBiologicalProcess	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	CLDN5 CLDN15 CLDN3	1.94e-04	26	90	3	GO:0016338
GeneOntologyBiologicalProcess	cellular response to alcohol	GPR155 P2RY4 CYP7A1 PRKAA2 PRKCE	2.64e-04	130	90	5	GO:0097306
GeneOntologyBiologicalProcess	positive regulation of cell junction assembly	AGT CLDN5 CLDN3 ADGRE2 ADGRL3	3.25e-04	136	90	5	GO:1901890
GeneOntologyBiologicalProcess	positive regulation of cardiac muscle cell apoptotic process	AGT CAPN1 CAPN2	3.64e-04	32	90	3	GO:0010666
GeneOntologyBiologicalProcess	positive regulation of striated muscle cell apoptotic process	AGT CAPN1 CAPN2	3.99e-04	33	90	3	GO:0010663
GeneOntologyBiologicalProcess	response to muscle activity	AGT CAPN3 PRKAA2	4.36e-04	34	90	3	GO:0014850
GeneOntologyBiologicalProcess	bicellular tight junction assembly	CLDN25 CLDN5 CLDN15 CLDN3	4.36e-04	81	90	4	GO:0070830
GeneOntologyCellularComponent	calpain complex	CAPN1 CAPN2	1.14e-04	4	92	2	GO:0110158
GeneOntologyCellularComponent	bicellular tight junction	CLDN25 ILDR1 CLDN5 CLDN15 CLDN3	2.85e-04	131	92	5	GO:0005923
GeneOntologyCellularComponent	tight junction	CLDN25 ILDR1 CLDN5 CLDN15 CLDN3	3.74e-04	139	92	5	GO:0070160
GeneOntologyCellularComponent	apical junction complex	CLDN25 ILDR1 CLDN5 CLDN15 CLDN3	6.71e-04	158	92	5	GO:0043296
GeneOntologyCellularComponent	lateral plasma membrane	SLC6A9 CLDN5 CLDN15 CLDN3	6.72e-04	90	92	4	GO:0016328
GeneOntologyCellularComponent	caspase complex	CAPN1 CAPN2	8.43e-04	10	92	2	GO:0008303
GeneOntologyCellularComponent	endopeptidase complex	CAPN1 CAPN2 PSMB11 PAAF1	1.07e-03	102	92	4	GO:1905369
GeneOntologyCellularComponent	apical part of cell	SLC6A9 SLC7A13 P2RY4 MYO7B PRKAA2 CLDN25 PLAT SLC5A8 TMEM235	1.19e-03	592	92	9	GO:0045177
Domain	Calpain_III	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.19e-09	12	83	5	IPR022683
Domain	calpain_III	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.19e-09	12	83	5	SM00720
Domain	C2_III	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.19e-09	12	83	5	IPR033883
Domain	Calpain_domain_III	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.92e-09	13	83	5	IPR022682
Domain	Calpain_III	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.92e-09	13	83	5	PF01067
Domain	Calpain_cysteine_protease	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	2.98e-09	14	83	5	IPR022684
Domain	CysPc	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	4.45e-09	15	83	5	SM00230
Domain	Peptidase_C2_calpain_cat	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	4.45e-09	15	83	5	IPR001300
Domain	Peptidase_C2	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	4.45e-09	15	83	5	PF00648
Domain	CALPAIN_CAT	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	4.45e-09	15	83	5	PS50203
Domain	THIOL_PROTEASE_CYS	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	9.38e-08	26	83	5	PS00139
Domain	THIOL_PROTEASE_ASN	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.15e-07	27	83	5	PS00640
Domain	THIOL_PROTEASE_HIS	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.15e-07	27	83	5	PS00639
Domain	Pept_cys_AS	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.39e-07	28	83	5	IPR000169
Domain	PMP22/EMP/MP20/Claudin	CLDN25 CLDN5 CLDN15 CLDN3 TMEM235	1.63e-06	45	83	5	IPR004031
Domain	Claudin	CLDN25 CLDN5 CLDN15 CLDN3	6.84e-06	28	83	4	IPR006187
Domain	EF-hand_8	CAPN1 CAPN2 CAPN3 CAPN11	1.52e-05	34	83	4	PF13833
Domain	PMP22_Claudin	CLDN25 CLDN5 CLDN15 CLDN3	2.93e-05	40	83	4	PF00822
Domain	EFh	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	7.35e-05	158	83	6	SM00054
Domain	Prot_kin_PKC_delta	PRKCE PRKCQ	1.16e-04	4	83	2	IPR014376
Domain	Claudin_CS	CLDN5 CLDN15 CLDN3	1.23e-04	22	83	3	IPR017974
Domain	CLAUDIN	CLDN5 CLDN15 CLDN3	1.23e-04	22	83	3	PS01346
Domain	EF_Hand_1_Ca_BS	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	1.29e-04	175	83	6	IPR018247
Domain	EF_HAND_1	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	2.96e-04	204	83	6	PS00018
Domain	GPS	ADGRE3 ADGRE2 ADGRL3	4.58e-04	34	83	3	SM00303
Domain	GPCR_2_secretin-like_CS	ADGRE3 ADGRE2 ADGRL3	4.58e-04	34	83	3	IPR017983
Domain	GPS	ADGRE3 ADGRE2 ADGRL3	5.00e-04	35	83	3	PF01825
Domain	TMC	TMC6 TMC4	5.37e-04	8	83	2	PF07810
Domain	TMC	TMC6 TMC4	5.37e-04	8	83	2	IPR012496
Domain	GPS	ADGRE3 ADGRE2 ADGRL3	5.44e-04	36	83	3	PS50221
Domain	EF_HAND_2	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	5.73e-04	231	83	6	PS50222
Domain	EF_hand_dom	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	5.86e-04	232	83	6	IPR002048
Domain	GPS	ADGRE3 ADGRE2 ADGRL3	5.90e-04	37	83	3	IPR000203
Domain	GPCR_Rhodpsn_7TM	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 FFAR1 OR4Q3 OR2T10 OR6M1	7.58e-04	670	83	10	IPR017452
Domain	7tm_1	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 FFAR1 OR4Q3 OR2T10 OR6M1	8.21e-04	677	83	10	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 FFAR1 OR4Q3 OR2T10 OR6M1	8.98e-04	685	83	10	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 FFAR1 OR4Q3 OR2T10 OR6M1	9.59e-04	691	83	10	PS50262
Domain	GPCR_Rhodpsn	OR2C1 OR4S1 MAS1L GPR25 P2RY4 OR2AP1 FFAR1 OR4Q3 OR2T10 OR6M1	9.70e-04	692	83	10	IPR000276
Domain	GAIN_dom_N	ADGRE3 ADGRL3	1.05e-03	11	83	2	IPR032471
Domain	GAIN	ADGRE3 ADGRL3	1.05e-03	11	83	2	PF16489
Domain	-	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	1.08e-03	261	83	6	1.10.238.10
Domain	G_PROTEIN_RECEP_F2_2	ADGRE3 ADGRE2 ADGRL3	1.43e-03	50	83	3	PS00650
Domain	7tm_2	ADGRE3 ADGRE2 ADGRL3	1.43e-03	50	83	3	PF00002
Domain	Prot_kinase_dom	AURKC FLT4 GUCY2F NRK PRKAA2 PRKCE PRKCQ STKLD1	1.47e-03	489	83	8	IPR000719
Domain	Pkinase	AURKC GUCY2F NRK PRKAA2 PRKCE PRKCQ STKLD1	1.53e-03	381	83	7	PF00069
Domain	PROTEIN_KINASE_DOM	AURKC FLT4 GUCY2F NRK PRKAA2 PRKCE PRKCQ STKLD1	1.55e-03	493	83	8	PS50011
Domain	EF-hand-dom_pair	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	1.75e-03	287	83	6	IPR011992
Domain	GPCR_2_secretin-like	ADGRE3 ADGRE2 ADGRL3	2.41e-03	60	83	3	IPR000832
Domain	GPCR_2-like	ADGRE3 ADGRE2 ADGRL3	2.41e-03	60	83	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	ADGRE3 ADGRE2 ADGRL3	2.53e-03	61	83	3	PS50261
Domain	Kinase-like_dom	AURKC FLT4 GUCY2F NRK PRKAA2 PRKCE PRKCQ STKLD1	2.80e-03	542	83	8	IPR011009
Domain	DAG/PE-bd	PRKCE PRKCQ	3.88e-03	21	83	2	IPR020454
Domain	PROTEIN_KINASE_ATP	AURKC FLT4 NRK PRKAA2 PRKCE PRKCQ STKLD1	4.31e-03	459	83	7	PS00107
Domain	EF-hand_1	CAPN1 CAPN2 SDF4 CAPN11	4.71e-03	152	83	4	PF00036
Domain	EF-hand_5	CAPN3 SDF4	5.48e-03	25	83	2	PF13202
Domain	Protein_kinase_ATP_BS	AURKC FLT4 NRK PRKAA2 PRKCE PRKCQ	6.82e-03	379	83	6	IPR017441
Domain	Olfact_rcpt	OR2C1 OR4S1 OR2AP1 OR4Q3 OR2T10 OR6M1	8.09e-03	393	83	6	IPR000725
Pathway	KEGG_MEDICUS_REFERENCE_TIGHT_JUNCTION_ACTIN_SIGNALING_PATHWAY	CLDN25 CLDN5 CLDN15 CLDN3	2.74e-05	37	67	4	M47769
Pathway	REACTOME_SENSORY_PERCEPTION	OR2C1 OR4S1 OR2AP1 GUCY2F OR11H7 ESPNL TAS1R1 OR4Q3 PRKCQ OR2T10 OR6M1	1.85e-04	636	67	11	M41834
Pathway	REACTOME_DEGRADATION_OF_THE_EXTRACELLULAR_MATRIX	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	2.05e-04	114	67	5	MM14571
Pubmed	NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain.	CAPN1 CAPN2 CAPN3	1.79e-08	3	92	3	8954122
Pubmed	Characterization of the calcium-dependent proteolytic system in a mouse muscle cell line.	CAPN1 CAPN2 CAPN3	7.15e-08	4	92	3	11952156
Pubmed	Protein expression patterns for ubiquitous and tissue specific calpains in the developing mouse lens.	CAPN1 CAPN2 CAPN3	7.15e-08	4	92	3	12634108
Pubmed	Regional differences in gene expression for calcium activated neutral proteases (calpains) and their endogenous inhibitor calpastatin in mouse brain and spinal cord.	CAPN1 CAPN2 CAPN3	7.15e-08	4	92	3	8738748
Pubmed	Four genes for the calpain family locate on four distinct human chromosomes.	CAPN1 CAPN2 CAPN3	7.15e-08	4	92	3	2209092
Pubmed	Calpain translocation during muscle fiber necrosis and regeneration in dystrophin-deficient mice.	CAPN1 CAPN2 CAPN3	1.78e-07	5	92	3	8806430
Pubmed	Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.	CAPN8 CAPN1 CAPN2	1.78e-07	5	92	3	17646163
Pubmed	Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity.	CAPN1 CAPN2 CAPN3	1.78e-07	5	92	3	17897354
Pubmed	Predicted expansion of the claudin multigene family.	CLDN25 CLDN3 TMEM235	3.56e-07	6	92	3	21276448
Pubmed	Structure and function of claudins.	CLDN25 CLDN5 CLDN15 CLDN3	3.91e-07	23	92	4	18036336
Pubmed	The claudins.	CLDN25 CLDN5 CLDN15 CLDN3	3.91e-07	23	92	4	19706201
Pubmed	Structure and physiological function of calpains.	CAPN1 CAPN2 CAPN3	6.22e-07	7	92	3	9396712
Pubmed	Altered gene expression for calpain/calpastatin system in motor neuron degeneration (Mnd) mutant mouse brain and spinal cord.	CAPN1 CAPN2 CAPN3	9.94e-07	8	92	3	9473662
Pubmed	Tight junction proteins at the blood-brain barrier: far more than claudin-5.	CLDN25 CLDN5 CLDN3	2.12e-06	10	92	3	30734065
Pubmed	Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.	P2RY4 PRKAA2 PRKCE	5.03e-06	13	92	3	23479225
Pubmed	Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland.	ILDR1 CLDN5 CLDN15 CLDN3	5.23e-06	43	92	4	34737342
Pubmed	Activation of calpains mediates early lung neutrophilic inflammation in ventilator-induced lung injury.	CAPN1 CAPN2	6.92e-06	2	92	2	22140070
Pubmed	Unique structural features of claudin-5 and claudin-15 lead to functionally distinct tight junction strand architecture.	CLDN5 CLDN15	6.92e-06	2	92	2	36114674
Pubmed	[Expression of calpain 1 and calpain 2 during the skin incised wound healing in mice].	CAPN1 CAPN2	6.92e-06	2	92	2	17619446
Pubmed	Involvement of calpains in Ca2+-induced disruption of excitation-contraction coupling in mammalian skeletal muscle fibers.	CAPN1 CAPN3	6.92e-06	2	92	2	19295178
Pubmed	Calpain 1 and 2 are required for RNA replication of echovirus 1.	CAPN1 CAPN2	6.92e-06	2	92	2	18032503
Pubmed	Calpain-2 participates in the process of calpain-1 inactivation.	CAPN1 CAPN2	6.92e-06	2	92	2	33078830
Pubmed	The CAPN2/CAPN8 Locus on Chromosome 1q Is Associated with Variation in Serum Alpha-Carotene Concentrations.	CAPN8 CAPN2	6.92e-06	2	92	2	28002826
Pubmed	mu-Calpain and calpain-3 are not autolyzed with exhaustive exercise in humans.	CAPN1 CAPN3	6.92e-06	2	92	2	16107503
Pubmed	Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant.	CAPN1 CAPN2	6.92e-06	2	92	2	9669314
Pubmed	Vitamin D₃ regulation of body fat, cytokines, and calpain gene expression.	CAPN1 CAPN2	6.92e-06	2	92	2	25520983
Pubmed	Palmitate-activated macrophages confer insulin resistance to muscle cells by a mechanism involving protein kinase C θ and ε.	PRKCE PRKCQ	6.92e-06	2	92	2	22046423
Pubmed	Calpain activation contributes to hyperglycaemia-induced apoptosis in cardiomyocytes.	CAPN1 CAPN2	6.92e-06	2	92	2	19505932
Pubmed	Tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induces phosphorylation of mu- and m-calpain in association with increased secretion, cell migration, and invasion.	CAPN1 CAPN2	6.92e-06	2	92	2	15471877
Pubmed	m-Calpain is required for preimplantation embryonic development in mice.	CAPN1 CAPN2	6.92e-06	2	92	2	16433929
Pubmed	Claudin-3 and claudin-5 protein folding and assembly into the tight junction are controlled by non-conserved residues in the transmembrane 3 (TM3) and extracellular loop 2 (ECL2) segments.	CLDN5 CLDN3	6.92e-06	2	92	2	24478310
Pubmed	Highly conserved structure in the promoter region of the gene for muscle-specific calpain, p94.	CAPN1 CAPN3	6.92e-06	2	92	2	8997499
Pubmed	Calpains are required for invasive and metastatic potentials of human HCC cells.	CAPN1 CAPN2	6.92e-06	2	92	2	23733271
Pubmed	Involvement of calpains in growth factor-mediated migration.	CAPN1 CAPN2	6.92e-06	2	92	2	16971167
Pubmed	Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.	CAPN1 CAPN2	6.92e-06	2	92	2	29258546
Pubmed	Protection against TBI-Induced Neuronal Death with Post-Treatment with a Selective Calpain-2 Inhibitor in Mice.	CAPN1 CAPN2	6.92e-06	2	92	2	28594313
Pubmed	Immunhistochemical analysis for expression of calpain 1, calpain 2 and calpastatin in ovarian cancer.	CAPN1 CAPN2	6.92e-06	2	92	2	22335024
Pubmed	Differential Activation of Calpain-1 and Calpain-2 following Kainate-Induced Seizure Activity in Rats and Mice.	CAPN1 CAPN2	6.92e-06	2	92	2	27622212
Pubmed	Distinct subcellular localisation of intramyocellular lipids and reduced PKCε/PKCθ activity preserve muscle insulin sensitivity in exercise-trained mice.	PRKCE PRKCQ	6.92e-06	2	92	2	36456864
Pubmed	Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase.	AGT PRKCE	6.92e-06	2	92	2	19193863
Pubmed	Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.	CAPN1 CAPN2	6.92e-06	2	92	2	19781581
Pubmed	Calpain-1 and calpain-2 play opposite roles in retinal ganglion cell degeneration induced by retinal ischemia/reperfusion injury.	CAPN1 CAPN2	6.92e-06	2	92	2	27185592
Pubmed	Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.	CAPN1 CAPN2	6.92e-06	2	92	2	22432027
Pubmed	Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.	PRKCE PRKCQ	6.92e-06	2	92	2	22812584
Pubmed	Cerebral calpain in fatal falciparum malaria.	CAPN1 CAPN2	6.92e-06	2	92	2	17359359
Pubmed	Isoform-specific hyperactivation of calpain-2 occurs presymptomatically at the synapse in Alzheimer's disease mice and correlates with memory deficits in human subjects.	CAPN1 CAPN2	6.92e-06	2	92	2	30177812
Pubmed	Calpains: markers of tumor aggressiveness?	CAPN1 CAPN2	6.92e-06	2	92	2	20193680
Pubmed	Differential implication of protein kinase C isoforms in cytotoxic T lymphocyte degranulation and TCR-induced Fas ligand expression.	PRKCE PRKCQ	6.92e-06	2	92	2	14645153
Pubmed	Different expression of calpains in the anterior vaginal wall of women with and without uterovaginal prolapse.	CAPN1 CAPN2	6.92e-06	2	92	2	14980313
Pubmed	Inhibition of calpain stabilises podosomes and impairs dendritic cell motility.	CAPN1 CAPN2	6.92e-06	2	92	2	16723743
Pubmed	Distinct roles for μ-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration.	CAPN1 CAPN2	6.92e-06	2	92	2	24285894
Pubmed	Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.	CAPN1 CAPN2	6.92e-06	2	92	2	15302874
Pubmed	Impact of ancestry and common genetic variants on QT interval in African Americans.	LITAF PRKCE CLDN15	1.68e-05	19	92	3	23166209
Pubmed	Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition.	CAPN1 CAPN2	2.07e-05	3	92	2	30177525
Pubmed	The tyrosine phosphatase PTPN13/FAP-1 links calpain-2, TBI and tau tyrosine phosphorylation.	CAPN1 CAPN2	2.07e-05	3	92	2	28924170
Pubmed	Dehydroepiandrosterone Sulfate Stimulates Expression of Blood-Testis-Barrier Proteins Claudin-3 and -5 and Tight Junction Formation via a Gnα11-Coupled Receptor in Sertoli Cells.	CLDN5 CLDN3	2.07e-05	3	92	2	26938869
Pubmed	Expression and immunolocalization of the calpain-calpastatin system in the human oocyte.	CAPN1 CAPN2	2.07e-05	3	92	2	15950654
Pubmed	Over-expression of calpastatin inhibits calpain activation and attenuates myocardial dysfunction during endotoxaemia.	CAPN1 CAPN2	2.07e-05	3	92	2	19318376
Pubmed	Calpain-2 compensation promotes angiotensin II-induced ascending and abdominal aortic aneurysms in calpain-1 deficient mice.	CAPN1 CAPN2	2.07e-05	3	92	2	23977256
Pubmed	PKCθ-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization.	FLT4 PRKCQ	2.07e-05	3	92	2	32382040
Pubmed	Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs.	CAPN1 CAPN2	2.07e-05	3	92	2	21839844
Pubmed	Extracellular Calpain/Calpastatin Balance Is Involved in the Progression of Pulmonary Hypertension.	CAPN1 CAPN2	2.07e-05	3	92	2	26974350
Pubmed	A novel role for calpain in the endothelial dysfunction induced by activation of angiotensin II type 1 receptor signaling.	CAPN1 CAPN2	2.07e-05	3	92	2	21415394
Pubmed	LOX-1 in macrophage migration in response to ox-LDL and the involvement of calpains.	CAPN1 CAPN2	2.07e-05	3	92	2	26393906
Pubmed	Genetic mapping of the glycine receptor alpha 3 subunit on mouse chromosome 8.	PLAT CPE	2.07e-05	3	92	2	7894176
Pubmed	Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation.	CLDN5 CLDN3	2.07e-05	3	92	2	28415153
Pubmed	Calpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.	CAPN1 CAPN2	2.07e-05	3	92	2	24550490
Pubmed	A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3.	CAPN1 CAPN2	2.07e-05	3	92	2	28334907
Pubmed	skNAC depletion stimulates myoblast migration and perturbs sarcomerogenesis by enhancing calpain 1 and 3 activity.	CAPN1 CAPN3	2.07e-05	3	92	2	23662692
Pubmed	The calpain small subunit regulates cell-substrate mechanical interactions during fibroblast migration.	CAPN1 CAPN2	2.07e-05	3	92	2	18840650
Pubmed	Inhibition of glycogen synthesis by fatty acid in C(2)C(12) muscle cells is independent of PKC-alpha, -epsilon, and -theta.	PRKCE PRKCQ	2.07e-05	3	92	2	12006349
Pubmed	Expression of typical calpains in mouse molar.	CAPN1 CAPN2	2.07e-05	3	92	2	19683220
Pubmed	The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells.	CAPN1 CAPN2	2.07e-05	3	92	2	21374734
Pubmed	Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media.	CLDN5 CLDN3	2.07e-05	3	92	2	18817843
Pubmed	Protein kinase Ciota promotes nicotine-induced migration and invasion of cancer cells via phosphorylation of micro- and m-calpains.	CAPN1 CAPN2	2.07e-05	3	92	2	16361262
Pubmed	Role of claudin interactions in airway tight junctional permeability.	CLDN5 CLDN3	2.07e-05	3	92	2	12909588
Pubmed	Neurotoxicity induces cleavage of p35 to p25 by calpain.	CAPN1 CAPN2	2.07e-05	3	92	2	10830966
Pubmed	Utrophin is a calpain substrate in muscle cells.	CAPN1 CAPN2	2.07e-05	3	92	2	16598790
Pubmed	Ubiquitous calpains promote both apoptosis and survival signals in response to different cell death stimuli.	CAPN1 CAPN2	2.07e-05	3	92	2	16632474
Pubmed	Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations.	CAPN1 CAPN2	2.07e-05	3	92	2	3038169
Pubmed	Conditional disruption of calpain in the CNS alters dendrite morphology, impairs LTP, and promotes neuronal survival following injury.	CAPN1 CAPN2	2.07e-05	3	92	2	23536090
Pubmed	Multifunctional strands in tight junctions.	CLDN5 CLDN15 CLDN3	2.30e-05	21	92	3	11283726
Pubmed	Claudin-based barrier in simple and stratified cellular sheets.	CLDN5 CLDN15 CLDN3	2.30e-05	21	92	3	12231346
Pubmed	Tight junction proteins.	CLDN5 CLDN15 CLDN3	2.30e-05	21	92	3	12475568
Pubmed	Tight junctions of the blood-brain barrier.	CLDN5 CLDN15 CLDN3	2.30e-05	21	92	3	10690502
Pubmed	The roles of claudin superfamily proteins in paracellular transport.	CLDN5 CLDN15 CLDN3	2.30e-05	21	92	3	11247307
Pubmed	Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer.	CAPN1 CAPN2	4.14e-05	4	92	2	27456359
Pubmed	Inhibition of the ERK1/2-ubiquitous calpains pathway attenuates experimental pulmonary fibrosis in vivo and in vitro.	CAPN1 CAPN2	4.14e-05	4	92	2	32017927
Pubmed	Tumor necrosis factor-alpha-inducible IkappaBalpha proteolysis mediated by cytosolic m-calpain. A mechanism parallel to the ubiquitin-proteasome pathway for nuclear factor-kappab activation.	CAPN2 CAPN3	4.14e-05	4	92	2	9873017
Pubmed	Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.	CAPN1 CAPN2	4.14e-05	4	92	2	16998475
Pubmed	17-Beta-estradiol increases neuronal excitability through MAP kinase-induced calpain activation.	CAPN1 CAPN2	4.14e-05	4	92	2	19995977
Pubmed	Calcium-dependent signaling pathways in T cells. Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events.	CAPN1 CAPN2	4.14e-05	4	92	2	9407132
Pubmed	PLEIAD/SIMC1/C5orf25, a novel autolysis regulator for a skeletal-muscle-specific calpain, CAPN3, scaffolds a CAPN3 substrate, CTBP1.	CAPN1 CAPN3	4.14e-05	4	92	2	23707407
Pubmed	Protein kinase Cδ mediates the activation of protein kinase D2 in platelets.	PRKCE PRKCQ	4.14e-05	4	92	2	21736870
Pubmed	The calpain family and human disease.	CAPN8 CAPN1	4.14e-05	4	92	2	11516996
Pubmed	Analysis of a human gene homologous to rat ventral prostate.1 protein.	CLDN5 CLDN3	4.14e-05	4	92	2	9441748
Pubmed	Transepithelial leak in Barrett's esophagus.	CLDN5 CLDN3	4.14e-05	4	92	2	17103306
Pubmed	A cascade of protein kinase C isozymes promotes cytoskeletal polarization in T cells.	PRKCE PRKCQ	4.14e-05	4	92	2	21602810
Pubmed	Calpain: novel family members, activation, and physiologic function.	CAPN1 CAPN2	4.14e-05	4	92	2	8561910
Pubmed	Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas.	CLDN5 CLDN3	4.14e-05	4	92	2	19231096
Interaction	CAPN8 interactions	CAPN8 CAPN1 CAPN3 CAPN11	6.37e-08	11	77	4	int:CAPN8
Interaction	CAPN11 interactions	CAPN8 CAPN2 CAPN3 CAPN11	3.46e-07	16	77	4	int:CAPN11
Interaction	CAPN3 interactions	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.95e-06	54	77	5	int:CAPN3
Interaction	CAPN9 interactions	CAPN2 CAPN3 CAPN11	2.96e-06	8	77	3	int:CAPN9
Interaction	TMEM52B interactions	FLT4 GPR25 TMEM54 TMEM86B CACHD1	5.35e-05	106	77	5	int:TMEM52B
Cytoband	1p35-p34	GUCA2A TMEM54	8.29e-05	7	92	2	1p35-p34
Cytoband	7q34	TRBV11-2 TRBV5-6 TRBV5-5 TRBV5-4	3.68e-04	167	92	4	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV11-2 TRBV5-6 TRBV5-5 TRBV5-4	5.41e-04	185	92	4	chr7q34
Cytoband	12q14.1	MON2 AGAP2	1.45e-03	28	92	2	12q14.1
Cytoband	12q23.1	SLC5A8 IKBIP	2.01e-03	33	92	2	12q23.1
GeneFamily	C2 domain containing\|Calpains	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.38e-09	15	64	5	975
GeneFamily	Claudins	CLDN25 CLDN5 CLDN15 CLDN3	1.20e-06	23	64	4	488
GeneFamily	CD molecules\|Adhesion G protein-coupled receptors, subfamily E	ADGRE3 ADGRE2	1.23e-04	5	64	2	915
GeneFamily	EF-hand domain containing	CAPN8 CAPN1 CAPN2 CAPN3 SDF4 CAPN11	1.23e-04	219	64	6	863
GeneFamily	T cell receptor beta locus at 7q34	TRBV11-2 TRBV5-6 TRBV5-5 TRBV5-4	2.55e-04	87	64	4	372
GeneFamily	Transmembrane channel likes	TMC6 TMC4	3.41e-04	8	64	2	1135
GeneFamily	C2 domain containing protein kinases	PRKCE PRKCQ	5.45e-04	10	64	2	835
GeneFamily	Olfactory receptors, family 2	OR2C1 OR2AP1 OR2T10	7.51e-03	113	64	3	149
GeneFamily	Serpin peptidase inhibitors	AGT SERPINA2	7.59e-03	37	64	2	739
GeneFamily	C1-set domain containing	TAPBPL SIRPA	9.70e-03	42	64	2	591
ToppCell	facs-Heart-LA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 GUCA2A MYO7B TMEM54 ILDR1 TMC4 CLDN3	5.35e-08	169	90	7	421fb287c7e439d1870b7950c5e3ca34106e014a
ToppCell	facs-Heart-LA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 GUCA2A MYO7B TMEM54 ILDR1 TMC4 CLDN3	5.35e-08	169	90	7	383639ec4f9d0c6255e0881edca15cdd1980a37c
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 MYO7B GUCY2F CYP7A1 NRK PKHD1L1 ADGRL3	9.58e-08	184	90	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 MYO7B GUCY2F CYP7A1 NRK PKHD1L1 ADGRL3	9.58e-08	184	90	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 MYO7B GUCY2F CYP7A1 NRK PKHD1L1 ADGRL3	9.58e-08	184	90	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	droplet-Large_Intestine\|droplet / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA2A MYO7B TMEM54 ILDR1 CLDN3 SLC5A8	1.96e-06	183	90	6	9d7ffcb9804b9a52448ccb56c9370b317a4b52a5
ToppCell	facs-Large_Intestine\|facs / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA2A MYO7B TMEM54 CLDN15 TMC4 CLDN3	2.43e-06	190	90	6	cf752ab09db7432a24ecdc60336ade738a9b703b
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A MYO7B AGT TMC4 CLDN3 CYP2W1	2.66e-06	193	90	6	32eb026d4317c1499d51294d396dfd5f293f9deb
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A MYO7B AGT TMC4 CLDN3 CYP2W1	2.66e-06	193	90	6	930df79b0600f43617052313294be33bcf5631f0
ToppCell	3'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A MYO7B AGT TMC4 CLDN3 CYP2W1	2.74e-06	194	90	6	07d8e38cbc2c7f0564c14f7c365f345f901b73b2
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLAT CLDN15 CPE TMEM235 CYP2W1 NMU	2.91e-06	196	90	6	429de4119c8b2193c992d36a6af84f806730cbee
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PLAT CLDN15 CPE TMEM235 CYP2W1 NMU	2.91e-06	196	90	6	8c8a73d9d9581b8d9a9babfa93459d12fb9eb3ac
ToppCell	5'-GW_trimst-2-LargeIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A TMEM54 AGT TMC4 CLDN3 CYP2W1	2.91e-06	196	90	6	79bc7ab96b52b2a542348a13ddd0a4f095698c5e
ToppCell	distal-Epithelial-Goblet\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CAPN8 TMEM54 UGT2A1 ILDR1 TMC4 CLDN3	2.99e-06	197	90	6	da1ed7303cc9cb2d205c0e5c49c52544d3540951
ToppCell	distal-Epithelial-Goblet-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	CAPN8 TMEM54 UGT2A1 ILDR1 TMC4 CLDN3	2.99e-06	197	90	6	3fbf456ae4f73da4f6254a6f0d24f0ec27d7a3cc
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN8 PRKAA2 UGT2A1 TMC4 CLDN3 SLC5A8	3.17e-06	199	90	6	7223f853335492ca617dbec3e4b6872a8a463a45
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_secretory-Secretory_Goblet\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CAPN8 PRKAA2 UGT2A1 TMC4 CLDN3 SLC5A8	3.17e-06	199	90	6	e03bdc7cb825e287f41b834ec6061d23c1c03b04
ToppCell	Fetal_29-31_weeks-Immune-mast_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRKCQ ADGRE2 PKHD1L1 ANKRD55 CAPN11	1.14e-05	145	90	5	dc89d817a9bef24a07e992efdab4136f12ceb399
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A13 P2RY4 TMEM54 ILDR1 TMC4	1.30e-05	149	90	5	dede8ffc14ce63e0058bde1394b31bb4088996b3
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A13 P2RY4 TMEM54 ILDR1 TMC4	1.30e-05	149	90	5	97015942c4ac797e1c12a1673cd147c10450b15a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuroepithelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC7A13 P2RY4 TMEM54 ILDR1 TMC4	1.35e-05	150	90	5	65ad642cd237ba0db4bde7371533884db2fa0aae
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 SLC7A13 AGT CLDN3 SLC5A8	1.95e-05	162	90	5	6972d45f4bd4b6522bf93295f7e9dca7c6cba1f3
ToppCell	facs-Heart-RA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA2A MYO7B TMEM54 CLDN3 SLC5A8	2.01e-05	163	90	5	13557be854878abc1bcdab909b49b8292d064145
ToppCell	facs-Heart-RA-18m-Myeloid-macrophage\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GUCA2A MYO7B TMEM54 CLDN3 SLC5A8	2.01e-05	163	90	5	6c1d1646410e785886d2de103b4b12f73e91edff
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Epcam____brush_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 SLC7A13 AGT CLDN3 SLC5A8	2.33e-05	168	90	5	35ce3b2b9c9997d4c101da5949c7271d6a6b8f12
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122\|Adult / Lineage, Cell type, age group and donor	FLT4 NRK PRKCE ENDOU CLDN5	2.53e-05	171	90	5	bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMEM196 AGT TMEM86B ILDR1 CPE	2.75e-05	174	90	5	d22b73b5aed85fb09fbe039f64504e19ebf9acb8
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_endothelial_cell_-_unspecif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRE3 TMC6 PLAT CLDN5 PRR7	2.75e-05	174	90	5	66a3b20ff1ab9f36fb391986444d7dc99d0c03d1
ToppCell	facs-BAT-Fat-3m-Epithelial\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASIC1 TMEM54 KCNK16 CLDN3 PRSS36	2.99e-05	177	90	5	3e42f6236962dd9bb23dc0d09b460ec8347d1056
ToppCell	facs-BAT-Fat-3m-Epithelial-epithelial_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASIC1 TMEM54 KCNK16 CLDN3 PRSS36	2.99e-05	177	90	5	128186bc996784e670194c07c5352e69af5f6d68
ToppCell	facs-BAT-Fat-3m-Epithelial-nan\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ASIC1 TMEM54 KCNK16 CLDN3 PRSS36	2.99e-05	177	90	5	7480e522cfae3f5c6c62720083750f8273725ab5
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLAT CLDN5 CLDN15 CPE PKHD1L1	3.07e-05	178	90	5	9f59a9af232d77bb55603a7776dbf9749ea652f2
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 PRKAA2 PLAT CLDN5 PKHD1L1	3.07e-05	178	90	5	4b3ea0921bc598ebb9f63780ecdf8ad4349f3666
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 PRKAA2 PLAT CLDN5 PKHD1L1	3.15e-05	179	90	5	9fd9b136ecbcbd4e4f0d5875ede98d8d48608afb
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FLT4 CLDN5 SIRPA TMEM235 PKHD1L1	3.15e-05	179	90	5	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	FLT4 CLDN5 SIRPA TMEM235 PKHD1L1	3.15e-05	179	90	5	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MON2 GPR25 CAPN3 TMEM86B PRSS36	3.24e-05	180	90	5	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	droplet-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	PLAT CLDN5 CLDN15 CPE PKHD1L1	3.32e-05	181	90	5	2c44c41b4e8a75ebdbaeb0c6cc5a03f17c44758c
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A AGT TMC4 CLDN3 CYP2W1	3.32e-05	181	90	5	bec917f6f56ae252639a5a76024be5df5c70a6d5
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FLT4 PRKCE CLDN5 TMEM235 ADGRL3	3.41e-05	182	90	5	a20017b6a4f9a6a29e090e4dbd7c02ed1495bd50
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC7A13 MYO7B AGT UGT2A1 SLC5A8	3.50e-05	183	90	5	d73cac83cde82665f110baad7cf28db75f9ffe52
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 PRKAA2 PLAT CLDN5 PKHD1L1	3.50e-05	183	90	5	2d0d3b486498a7903fa9a1f48b189291da49c430
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell-Mesothelium\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN15 CPE TMEM235 PKHD1L1 NMU	3.50e-05	183	90	5	9d5a363fbe6f0a1668c9d584df65ee1c283349c7
ToppCell	5'-GW_trimst-2-LargeIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CLDN15 CPE TMEM235 PKHD1L1 NMU	3.50e-05	183	90	5	c5caac6ed6c8d67f5c336281d9fd903976509445
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NRK CPE PRKCQ SIRPA ADGRL3	3.50e-05	183	90	5	cfae90c309622b5d499e62a3a8a8b9746478d28d
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 FLT4 PRKCQ SIRPA PKHD1L1	3.50e-05	183	90	5	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GPR155 SLC7A13 MYO7B ASIC1 SLC5A8	3.59e-05	184	90	5	9434731f651820b05335085582960f08fbf895de
ToppCell	facs-Trachea-18m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLT4 ABCB6 CLDN5 PRKCQ PKHD1L1	3.69e-05	185	90	5	59acaf025353405948dc34ccccf37ec5c08ea903
ToppCell	COVID-19-lung-Vein_EC\|lung / Disease (COVID-19 only), tissue and cell type	PLAT CLDN5 CPE CACHD1 PKHD1L1	3.98e-05	188	90	5	d582b76fc2faac526c9bf97503041129e1a6a211
ToppCell	Adult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Adult / Lineage, Cell type, age group and donor	FLT4 NRK PRKCE CLDN5 ADGRL3	3.98e-05	188	90	5	e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGT CPE TMC4 CLDN3 SLC5A8	4.08e-05	189	90	5	27e5d706f10a6221f314faf642eede15deab3165
ToppCell	MatrixFB-Fibroblast-C\|MatrixFB / shred on cell class and cell subclass (v4)	LOXL1 NRK CLDN15 CPE PKHD1L1	4.19e-05	190	90	5	d0106f7a21292f0b96ce4337ec3efbb1bd78dd0a
ToppCell	COVID-19-lung-Vein_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PLAT CLDN5 CPE CACHD1 PKHD1L1	4.19e-05	190	90	5	1caeaef78326734c1e31a0c4739190d5c5a77b9e
ToppCell	Control-Endothelial-VE_Venous\|Endothelial / Disease state, Lineage and Cell class	LITAF PLAT CPE CACHD1 ANKRD55	4.19e-05	190	90	5	4e30155203b4a8c5e496fcbe9348b67b98ebc625
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_progenitor_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGT CPE TMC4 CLDN3 SLC5A8	4.19e-05	190	90	5	0bad41d19dc515e6bc61e699f4d56664cf2e72fd
ToppCell	5'-Adult-LymphNode-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 PRKAA2 PLAT CLDN5 PKHD1L1	4.19e-05	190	90	5	6b704deeb44e1ffa10e604d0e5612b022f6cd9a6
ToppCell	droplet-Fat-Scat-18m-Epithelial-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 TMEM54 TMC4 CLDN3 SLC5A8	4.40e-05	192	90	5	4098b5170c9995718758a082d1b8bcb86d5a289e
ToppCell	droplet-Fat-Scat-18m-Epithelial\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 TMEM54 TMC4 CLDN3 SLC5A8	4.40e-05	192	90	5	936028fe851e8dd2b906df0210acc574c017b499
ToppCell	droplet-Fat-Scat-18m-Epithelial-epithelial_cell\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPN8 TMEM54 TMC4 CLDN3 SLC5A8	4.40e-05	192	90	5	62e55ed0d46b2e7b07dc42399972a099576cbc5f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	SLC7A13 MYO7B ASIC1 AGT SLC5A8	4.40e-05	192	90	5	3e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LITAF NRK PLAT CPE ADGRL3	4.51e-05	193	90	5	68089ba4123e2f9bea9aae0023a844b5a57bfc0e
ToppCell	facs-Mammary_Gland-Mammary_Gland-18m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AGT CPE TMC4 CLDN3 SLC5A8	4.51e-05	193	90	5	1526f51b589a7dc7a28f35f0e788dc38d338d2bc
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC6_(ADAMTS4+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 PRKAA2 CLDN5 SIRPA PKHD1L1	4.62e-05	194	90	5	937ee85ffd50869b60f0f6e91017ab77e8b24c0b
ToppCell	3'-Airway_Nasal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM54 PRKAA2 UGT2A1 SLC5A8 NMU	4.74e-05	195	90	5	7ffbdbe95b248699bf6300322d084d21a4a4b1b8
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A AGT TMC4 CLDN3 CYP2W1	4.85e-05	196	90	5	0df0dbe60e6f643912e5ff30c22415a0513f9bf1
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A AGT TMC4 CLDN3 CYP2W1	4.85e-05	196	90	5	153326be031a58b720da4dab57edd8936d513f8e
ToppCell	11.5-Distal-Epithelial-Secretory_progenitor\|Distal / Age, Tissue, Lineage and Cell class	TMEM54 ILDR1 TMC4 CLDN3 CYP2W1	4.85e-05	196	90	5	2648d64b0e7b59ae78182d55f32699ceea37ff8d
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A AGT TMC4 CLDN3 CYP2W1	4.85e-05	196	90	5	b7748618aaf3ace40940be1b6ca2148e941541a2
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC7A13 MYO7B AGT UGT2A1 SLC5A8	4.85e-05	196	90	5	4ebcaac758ed01d918de9c1cd383a84457b615f3
ToppCell	3'-Airway_Nasal-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TMEM54 PRKAA2 UGT2A1 SLC5A8 NMU	4.85e-05	196	90	5	eadc3e60104214cb5f6cfb098a5c5ea0f83d15bd
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLAT CLDN5 CPE PKHD1L1 CAPN11	4.97e-05	197	90	5	8437c33e2c4a10a1b95343431e48d5e820b1f742
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLAT CLDN5 CPE PKHD1L1 CAPN11	4.97e-05	197	90	5	0542badae77d2f606c13cfaf361319495c354351
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PLAT CLDN5 CPE PKHD1L1 CAPN11	4.97e-05	197	90	5	a6a64581699cfcb9607b288976fa3b09648725b7
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCA2A TMEM54 CLDN15 TMC4 CLDN3	5.09e-05	198	90	5	e3e2233c796d5e9051c8c1b66f70f406f048ed56
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7B AGT TMEM86B CLDN3 CYP2W1	5.22e-05	199	90	5	a10768e1cddd2d38291c30d24820a94040a72211
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7B TMEM86B CLDN15 CLDN3 CYP2W1	5.22e-05	199	90	5	914f66e2b4af323d09fa2340a39cf8051d00a422
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7B AGT TMEM86B CLDN3 CYP2W1	5.22e-05	199	90	5	f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7B AGT CAPN3 CLDN3 CYP2W1	5.34e-05	200	90	5	3e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCell	medial-Endothelial-Vein-2\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLAT CLDN5 CPE PKHD1L1 CAPN11	5.34e-05	200	90	5	3f689029f5bc7db0af50a405f1e252aeec529077
ToppCell	5'-Adult-SmallIntestine-Endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	FLT4 PLAT CLDN5 CPE PKHD1L1	5.34e-05	200	90	5	2554b77edfe3d378296b0b25625caacbfb1c0e76
ToppCell	medial-Endothelial-Vein\|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLAT CLDN5 CPE PKHD1L1 CAPN11	5.34e-05	200	90	5	1163e5f6dfb304c94bf8885629350454f4b6bee8
ToppCell	medial-2-Endothelial-Vein\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	PLAT CLDN5 CPE PKHD1L1 CAPN11	5.34e-05	200	90	5	49da4e3ff10262a492c2cf566a7f2e35e418bfda
ToppCell	5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO7B AGT CAPN3 CLDN3 CYP2W1	5.34e-05	200	90	5	73bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCell	Substantia_nigra\|World / BrainAtlas - Mouse McCarroll V32	SLC6A9 AGT CACHD1 XPR1	8.74e-05	115	90	4	18174b8d57d444fab1e9d2b13d22939c83c958e0
ToppCell	TCGA-Thymus\|World / Sample_Type by Project: Shred V9	TRBV11-2 TRBV5-6 TRBV5-5 PSMB11	1.21e-04	125	90	4	109857418118020d35f05a5eb8a25bb7e3d8ed2a
ToppCell	COVID_vent-Lymphocytic-T_cell-Gamma_Delta_T_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	AURKC FLT4 ASIC1 UGT2A1	1.49e-04	132	90	4	dbc0a332fd8f63ebdcf9716e45d7f46f26509349
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Gad2-Inhibitory_Neuron.Gad1Gad2.Gad2-Kcnc3_(GABAergic,_K/Na_Channel_State)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	AURKC FFAR1 NMU	1.69e-04	53	90	3	a58b0b1c9991cfebf20e206a129b79f494785138
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Gad2-Inhibitory_Neuron.Gad1Gad2.Gad2-Kcnc3_(GABAergic,_K/Na_Channel_State)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	AURKC FFAR1 NMU	1.69e-04	53	90	3	e90685a7c6ef223783b1c1a6b1896fd566449422
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Gad2\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	AURKC FFAR1 NMU	1.69e-04	53	90	3	5ad1a5c5c9a1dc66dd7e6de6edbee0176678966c
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(CH25H+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GUCY2F PLAT ADGRL3 CAPN11	2.19e-04	146	90	4	669001b772b6d6109a09727619ed5829122b48db
ToppCell	droplet-Heart-4Chambers-18m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 ESPNL CPE CLDN3	2.37e-04	149	90	4	38890ddde0979977c8350f01497f1245ab51641a
ToppCell	E18.5-samps-Mesenchymal-Pericyte-pericyte_D\|E18.5-samps / Age Group, Lineage, Cell class and subclass	TMEM196 LOXL1 NRK SLC5A8	2.37e-04	149	90	4	dcf68eb25733b5db2893728fe4dca5c7267eb58c
ToppCell	TCGA-Thymus-Primary_Tumor-Thymoma-Type_B2\|TCGA-Thymus / Sample_Type by Project: Shred V9	TRBV11-2 GUCY2F TRBV5-6 TRBV5-4	2.55e-04	152	90	4	752fdd3d55f5ad5a21562934a218e1fd50d152b1
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ASIC1 CLDN15 CPE PKHD1L1	2.82e-04	156	90	4	574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCell	PND07-28-samps-Mesenchymal-Mesothelial-Mesothelial\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	ASIC1 CLDN15 CPE PKHD1L1	2.82e-04	156	90	4	605d95a900e1443d3f6aae163ef2e893d3293203
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L5-6_SST_ISOC1\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXL2NB SLC5A8 MUCL3 NMU	2.96e-04	158	90	4	b70b4dbcb0ee96d98578c14e89b1c3f74e84c517
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPR155 TRBV5-6 TRBV5-4 PRKCQ	3.18e-04	161	90	4	b24293fdae9637983fcf4f2d4659a3554e00a53f
ToppCell	facs-Marrow-T-cells-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 TMEM86B CACHD1 PKHD1L1	3.18e-04	161	90	4	79a4a81963c92ade5b6910816a440dc3c233ead2
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GPR155 TRBV5-6 TRBV5-4 PRKCQ	3.18e-04	161	90	4	eddcbe266d4a84a340fa8f2128d2b7e293968dca
ToppCell	facs-Marrow-T-cells-24m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC6A9 TMEM86B CACHD1 PKHD1L1	3.18e-04	161	90	4	1ce40a6d0f0b9870e7ddb3d607668adcbd3dd1d3
Drug	AC1Q6PMP	FLT4 SLC7A13 GUCA2A TMEM54 AGT CAPN1 CAPN2 CAPN3 PLAT CAPN11	8.46e-10	169	86	10	CID000103535
Drug	chloromethyl	TMEM54 CAPN1 CAPN2 CAPN3 PRKCE PLAT PRKCQ CAPN11	7.52e-07	195	86	8	CID000007835
Drug	oxindole	FLT4 SIRPA SLC5A8 CYP2W1	8.07e-06	34	86	4	CID000321710
Drug	Sopharanol	CPE SLC5A8	1.41e-05	2	86	2	CID000619052
Disease	hereditary spastic paraplegia 76 (implicated_via_orthology)	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.66e-13	5	84	5	DOID:0110821 (implicated_via_orthology)
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	5.83e-08	36	84	5	DOID:11723 (implicated_via_orthology)
Disease	hereditary spastic paraplegia (implicated_via_orthology)	CAPN8 CAPN1 CAPN2 CAPN3 CAPN11	1.47e-07	43	84	5	DOID:2476 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	CAPN8 CAPN2 CAPN3 PRKAA2 CPE NMU CAPN11	2.78e-06	215	84	7	DOID:9970 (implicated_via_orthology)
Disease	intellectual disability (implicated_via_orthology)	CAPN8 CAPN2 CAPN3 CAPN11	6.37e-05	75	84	4	DOID:1059 (implicated_via_orthology)
Disease	alpha-carotene measurement	CAPN8 PRKCE	7.96e-05	5	84	2	EFO_0007893
Disease	Cardiomyopathies, Primary	AGT PRKAA2 PRKCE	1.02e-03	69	84	3	C0033141
Disease	Myocardial Diseases, Secondary	AGT PRKAA2 PRKCE	1.02e-03	69	84	3	C0036529
Disease	carnitine measurement	TMEM196 SLC7A13 NRK	1.35e-03	76	84	3	EFO_0010469
Disease	type 2 diabetes mellitus (is_implicated_in)	FFAR1 PRKAA2 PLAT CPE	1.46e-03	171	84	4	DOID:9352 (is_implicated_in)
Disease	traumatic brain injury (biomarker_via_orthology)	CAPN1 CAPN2	2.12e-03	24	84	2	DOID:0081292 (biomarker_via_orthology)
Disease	Impaired glucose tolerance	AGT PRKAA2	2.30e-03	25	84	2	C0271650
Disease	middle cerebral artery infarction (biomarker_via_orthology)	AGT PLAT CLDN5	2.40e-03	93	84	3	DOID:3525 (biomarker_via_orthology)
Disease	Myocardial Infarction	AGT PRKCE PLAT	2.55e-03	95	84	3	C0027051

Protein segments in the cluster

Peptide	Gene	Start	Entry
LATLWSVGIALCCGL	ERVPABLB-1	456	P60509
DLWCIGVLCYELLVG	AURKC	221	Q9UQB9
IGLAPCCLWLLGAVL	SDF4	16	Q9BRK5
AQLFILGCTWCLGIL	ADGRE2	736	Q9UHX3
LGFALWGVLGISCDC	ALG6	171	Q9Y672
WGVLGISCDCDLLGS	ALG6	176	Q9Y672
DIWSCGVILYALLCG	PRKAA2	196	P54646
ALASCCGVWAVALLA	GPR25	156	O00155
GAIALLCLLGLTWAF	ADGRL3	1056	Q9HAR2
WLLCLVACWLLGAGA	CACHD1	21	Q5VU97
LGGLLLSLLGWVCSC	CLDN25	11	C9JDP6
LLGLWGLLCACAQDP	CYP2W1	11	Q8TAV3
SVLESLAGACGLWLL	ABCB6	111	Q9NP58
WASLNLGALICIECS	AGAP2	956	Q99490
TSLCLATYLGWLEGC	ANKRD55	96	Q3KP44
DICQGGLGDCWLLAA	CAPN8	96	A6NHC0
GLGDCWLLAAIASLT	CAPN8	101	A6NHC0
ICQGILGDCWLLAAI	CAPN11	131	Q9UMQ6
DICQGALGDCWLLAA	CAPN1	106	P07384
TILCLLAWAGLAAGD	AGT	11	P01019
AGALTWLSCGSLCLL	LITAF	111	Q99732
GSLAELCWLVREGGC	ESPNL	81	Q6ZVH7
LLWGLARQGLKCDAC	PRKCQ	251	Q04759
LLLLAWCAGACRGAP	NMU	26	P48645
LGCLGECLGLEWLDL	LRRC61	46	Q9BV99
FCGCDLVSWLIEVGL	GPR155	781	Q7Z3F1
LCSCWGGRVLPLLLA	KCNK16	6	Q96T55
LAATLCLEGWPLRCL	FOXL2NB	151	Q6ZUU3
CDHCGSLLWGLLRQG	PRKCE	256	Q02156
GSRQLGALVWGACLC	LOXL1	6	Q08397
LCLWLVLACWCGGFI	OR4Q3	141	Q8NH05
CRKCGLLAGASWLAG	OR4S1	136	Q8NGB4
SLVLAVLCGLAWAGK	ENDOU	6	P21128
LGALLLLLLIGVCWC	ILDR1	176	Q86SU0
ACWCGLLAALSLLLD	MON2	556	Q7Z3U7
SRICIQLIFCSWLGG	OR2AP1	136	Q8NGE2
GLDLCVATALCGWDR	PSMB11	141	A5LHX3
CWLLAVIACLGGLGN	OR2C1	141	O95371
SRACLLLVLGCWVGA	OR6M1	136	Q8NGM8
LSALCLLGAWAALAG	GUCA2A	6	Q02747
CLSLLSLGTCLGLAW	IKBIP	46	Q70UQ0
LLNGTVFWLLCCGAT	MAS1L	91	P35410
RLWDCGRSACLGVLA	PAAF1	201	Q9BRP4
CLLLASGCWFVGSVD	OR2T10	141	Q8NGZ9
GFWLIWGLIVLLCCF	PRR7	16	Q8TB68
LAGLLCLAVWLVVAG	P2RY4	151	P51582
LCVLALGLGRLLCWW	HHAT	241	Q5VTY9
LLEAELLGGWWCHCL	PRSS36	461	Q5K4E3
SWGVLLLAGLCCLVP	SERPINA2	6	P20848
VCAAIWALVLCHLGL	FFAR1	126	O14842
GLASAKFLWCLCLLS	GUCY2F	26	P51841
LLVQGAWLCLCGRGL	C17orf107	146	Q6ZR85
ALCGALAACGWLLGA	CPE	11	P16870
WSASLISILGGLCLC	CLDN15	166	P56746
AIAACCCLWLILGIR	CYP7A1	11	P22680
DICQGALGDCWLLAA	CAPN2	96	P17655
LGDCWFLAAIACLTL	CAPN3	126	P20807
CCLLFLLASWGAGAT	MUCL3	16	Q3MIW9
CGILVSLCWLIGFLG	OR11H7	141	Q8NGC8
EICCGSLWGVNLLLG	NRK	1211	Q7Z2Y5
GWCLLLCLALSGAAE	TAPBPL	6	Q9BX59
LGPLLCLLLAASCAW	SIRPA	11	P78324
CLLLAASCAWSGVAG	SIRPA	16	P78324
GLWAILTCSVFCGLA	SLC5A8	286	Q8N695
AQLFILGCTWCLGLL	ADGRE3	556	Q9BY15
WALCFLGSLAVLLCV	ASIC1	46	P78348
ALAVLGWLGTIVCCA	CLDN3	11	O15551
LVLCLVGWGGLILAC	CLDN5	11	O00501
GFLGILWCLSLLACF	XPR1	321	Q9UBH6
LCWVLLCLLGAGPVD	TRBV5-5	6	A0A597
IALAALWFCLIGLIC	TMTC4	356	Q5T4D3
WSGVCFLLCGICGIL	TMEM196	51	Q5HYL7
LACIGIGGCTLSSWL	TMEM196	116	Q5HYL7
LCGGILISSCWILSA	PLAT	341	P00750
LLVCGWICGLLSSLA	TMEM235	106	A6NFC5
SLCLWGIALVLCVAE	TMEM54	156	Q969K7
ARLVGLQLLISCCWA	TAS1R1	6	Q7RTX1
CVALCSLGIWICEEL	RALGAPA1	1291	Q6GYQ0
DVCASGLGLLWALLL	STKLD1	476	Q8NE28
LLGATENGILCCWNL	WDR75	556	Q8IWA0
CWAFAVGLICLLLIL	TMC4	256	Q7Z404
ALCLRLWLCLGLLDG	FLT4	6	P35916
LCWAALCLLGAELTE	TRBV11-2	6	A0A584
LGCLGVSWLVVFLCL	SLC6A9	291	P48067
CEGGLRCLCWKILLN	TBC1D13	36	Q9NVG8
LVCSAVGDACLIWPA	TMEM86B	81	Q8N661
VGVSLCVWAGCAILA	SLC7A13	46	Q8TCU3
LLGIWGLCGLLLCAA	PKHD1L1	6	Q86WI1
LCWALLCLLGAGSVE	TRBV5-4	6	A0A0C4DH59
LGLCNWSTLGVCAAL	SLC66A3	6	Q8N755
LCWALLCLLGAGLVD	TRBV5-6	6	A0A599
AAVLGLVWLLCLGTA	TMC6	431	Q7Z403
LVWLLCLGTALGCAV	TMC6	436	Q7Z403
LLLCCPGWSAVADLG	UGT2A1	241	P0DTE4
ENLALISSLGCWCGV	ZNF814	46	B7Z6K7
LIVLTGGFTWLCICC	KIAA0319	966	Q5VV43
SLARGWILLSLCLGC	MYO7B	1126	Q6PIF6