Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.06e-32	114	53	20	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.50e-31	124	53	20	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.11e-30	137	53	20	GO:0019783
GeneOntologyMolecularFunction	cysteine-type peptidase activity	USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 CTSV USP17L15 USP17L8 USP17L13 USP17L18	3.48e-29	192	53	21	GO:0008234
GeneOntologyMolecularFunction	peptidase activity	MEP1A BMP1 USP17L21 USP17L4 USP17L2 USP17L23 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 CTSV USP17L15 USP17L8 USP17L13 USP17L18	1.20e-20	654	53	23	GO:0008233
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT1 GALNT13	1.27e-03	20	53	2	GO:0004653
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.59e-30	125	50	19	GO:0016579
GeneOntologyBiologicalProcess	protein modification by small protein removal	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	8.02e-29	144	50	19	GO:0070646
GeneOntologyBiologicalProcess	protein modification by small protein conjugation or removal	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 HERC1 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.96e-14	1009	50	20	GO:0070647
GeneOntologyBiologicalProcess	post-translational protein modification	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 HERC1 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.91e-13	1074	50	20	GO:0043687
GeneOntologyBiologicalProcess	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	USP17L24 USP17L6P	1.60e-04	8	50	2	GO:0071947
GeneOntologyBiologicalProcess	protein O-linked glycosylation via serine	GALNT1 GALNT13	2.56e-04	10	50	2	GO:0018242
GeneOntologyBiologicalProcess	protein O-linked glycosylation via threonine	GALNT1 GALNT13	2.56e-04	10	50	2	GO:0018243
GeneOntologyCellularComponent	endoplasmic reticulum membrane	USP17L21 USP17L4 USP17L2 GALNT1 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 NOTCH2 USP17L8 USP17L13 USP17L18	1.65e-11	1293	53	20	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	USP17L21 USP17L4 USP17L2 GALNT1 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 NOTCH2 USP17L8 USP17L13 USP17L18	1.79e-11	1299	53	20	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	USP17L21 USP17L4 USP17L2 GALNT1 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 NOTCH2 USP17L8 USP17L13 USP17L18	2.64e-11	1327	53	20	GO:0042175
HumanPheno	Increased basophil count	TET2 KIT	3.04e-05	4	12	2	HP:0031807
HumanPheno	Chronic myelomonocytic leukemia	TET2 KIT	3.04e-05	4	12	2	HP:0012325
HumanPheno	Abnormal basophil count	TET2 KIT	5.07e-05	5	12	2	HP:0031806
HumanPheno	Elevated bronchoalveolar lavage fluid neutrophil proportion	NKX2-1 MUC5B	7.59e-05	6	12	2	HP:0032977
HumanPheno	Granulocytic hyperplasia	TET2 KIT	7.59e-05	6	12	2	HP:0012138
HumanPheno	Abnormal serum mast cell beta-tryptase concentration	TET2 KIT	7.59e-05	6	12	2	HP:0031900
HumanPheno	Elevated total serum tryptase	TET2 KIT	7.59e-05	6	12	2	HP:0031901
HumanPheno	Abnormal basophil morphology	TET2 KIT	1.41e-04	8	12	2	HP:0001912
HumanPheno	Anaphylactic shock	TET2 KIT	1.41e-04	8	12	2	HP:0100845
HumanPheno	Multiple myeloma	TET2 KIT	1.41e-04	8	12	2	HP:0006775
HumanPheno	Abnormal mast cell morphology	TET2 KIT	1.41e-04	8	12	2	HP:0100494
HumanPheno	Abnormal number of granulocyte precursors	TET2 KIT	1.81e-04	9	12	2	HP:0012137
HumanPheno	Abnormal cellular composition of bronchoalveolar fluid	NKX2-1 MUC5B	2.27e-04	10	12	2	HP:0032974
HumanPheno	Severe expressive language delay	KMT2C HERC1	3.31e-04	12	12	2	HP:0006863
HumanPheno	Abnormal granulocytopoietic cell morphology	TET2 KIT	5.25e-04	15	12	2	HP:0012135
HumanPheno	Chronic lymphatic leukemia	TET2 KIT	5.99e-04	16	12	2	HP:0005550
HumanPheno	Myeloproliferative disorder	TET2 KIT	5.99e-04	16	12	2	HP:0005547
HumanPheno	Normocytic anemia	TET2 KIT	6.78e-04	17	12	2	HP:0001897
MousePheno	increased trophectoderm apoptosis	USP17L2 USP17L15 USP17L13	4.96e-07	8	30	3	MP:0012119
MousePheno	abnormal preimplantation embryo development	AMBP USP17L2 HMCN1 THOC3 USP17L15 USP17L13	1.43e-06	171	30	6	MP:0009781
MousePheno	decreased testis weight	USP17L2 NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	1.03e-05	370	30	7	MP:0004852
MousePheno	abnormal B cell number	TET2 USP17L2 GALNT1 APEX2 KIT USP17L15 NOTCH2 USP17L13	1.07e-05	526	30	8	MP:0002458
MousePheno	abnormal testis weight	USP17L2 NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	1.48e-05	391	30	7	MP:0004850
MousePheno	increased thymus weight	USP17L2 USP17L15 USP17L13	1.75e-05	24	30	3	MP:0004955
MousePheno	abnormal B cell morphology	TET2 USP17L2 GALNT1 APEX2 KIT USP17L15 NOTCH2 USP17L13	2.68e-05	597	30	8	MP:0004939
MousePheno	increased lymphocyte cell number	TET2 USP17L2 GALNT1 FNDC3A GK5 KIT CTSV USP17L15 USP17L13	2.94e-05	797	30	9	MP:0005013
MousePheno	abnormal embryonic tissue physiology	USP17L2 THOC3 KIT USP17L15 NOTCH2 USP17L13	3.38e-05	297	30	6	MP:0008932
MousePheno	abnormal T cell number	TET2 USP17L2 GALNT1 APEX2 GK5 KIT CTSV USP17L15 USP17L13	3.61e-05	818	30	9	MP:0006387
MousePheno	increased CD8-positive, alpha-beta T cell number	USP17L2 GK5 CTSV USP17L15 USP17L13	5.38e-05	195	30	5	MP:0008078
MousePheno	abnormal T cell morphology	TET2 USP17L2 GALNT1 APEX2 GK5 KIT CTSV USP17L15 USP17L13	6.29e-05	878	30	9	MP:0008037
MousePheno	embryonic lethality before implantation, complete penetrance	USP17L2 HMCN1 KIT USP17L15 USP17L13	6.52e-05	203	30	5	MP:0011094
MousePheno	abnormal lymphocyte cell number	TET2 USP17L2 GALNT1 APEX2 FNDC3A GK5 KIT CTSV USP17L15 NOTCH2 USP17L13	8.26e-05	1390	30	11	MP:0000717
MousePheno	abnormal thymus morphology	TET2 NAA25 USP17L2 APEX2 KIT CTSV USP17L15 USP17L13	9.84e-05	717	30	8	MP:0000703
MousePheno	abnormal regulatory T cell number	USP17L2 CTSV USP17L15 USP17L13	1.01e-04	115	30	4	MP:0004972
MousePheno	abnormal regulatory T cell morphology	USP17L2 CTSV USP17L15 USP17L13	1.08e-04	117	30	4	MP:0004941
MousePheno	abnormal lymphocyte morphology	TET2 USP17L2 GALNT1 APEX2 FNDC3A GK5 KIT CTSV USP17L15 NOTCH2 USP17L13	1.49e-04	1483	30	11	MP:0002619
MousePheno	embryonic lethality before implantation	USP17L2 HMCN1 KIT USP17L15 USP17L13	1.49e-04	242	30	5	MP:0006204
MousePheno	decreased T cell number	USP17L2 GALNT1 APEX2 KIT CTSV USP17L15 USP17L13	1.55e-04	566	30	7	MP:0005018
MousePheno	abnormal hair cycle catagen phase	GK5 CTSV	1.59e-04	9	30	2	MP:0008859
MousePheno	decreased lymphocyte cell number	TET2 USP17L2 GALNT1 APEX2 KIT CTSV USP17L15 NOTCH2 USP17L13	1.61e-04	992	30	9	MP:0005016
MousePheno	abnormal cell proliferation	KMT2C USP17L2 GALNT1 APEX2 ZNF423 KIT CTSV USP17L15 NOTCH2 USP17L13	2.38e-04	1294	30	10	MP:0000350
MousePheno	increased B cell number	TET2 USP17L2 KIT USP17L15 USP17L13	2.53e-04	271	30	5	MP:0005014
MousePheno	small testis	USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	2.56e-04	823	30	8	MP:0001147
MousePheno	abnormal thymus weight	USP17L2 USP17L15 USP17L13	2.81e-04	60	30	3	MP:0004954
MousePheno	increased embryonic tissue cell apoptosis	USP17L2 USP17L15 NOTCH2 USP17L13	3.03e-04	153	30	4	MP:0013504
MousePheno	decreased regulatory T cell number	USP17L2 USP17L15 USP17L13	3.40e-04	64	30	3	MP:0004974
MousePheno	aortic valve regurgitation	GALNT1 CTSV	3.42e-04	13	30	2	MP:0006047
MousePheno	small gonad	USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	4.19e-04	885	30	8	MP:0001116
MousePheno	increased T cell number	TET2 USP17L2 GK5 CTSV USP17L15 USP17L13	4.42e-04	475	30	6	MP:0005015
MousePheno	abnormal endocrine gland morphology	TET2 NAA25 USP17L2 APEX2 NKX2-1 KIT CTSV USP17L15 USP17L13	4.71e-04	1144	30	9	MP:0013560
MousePheno	abnormal primary sex determination	USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	4.72e-04	901	30	8	MP:0002211
MousePheno	increased alpha-beta T cell number	USP17L2 GK5 CTSV USP17L15 USP17L13	4.76e-04	311	30	5	MP:0012764
MousePheno	abnormal testis size	USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	5.24e-04	915	30	8	MP:0004849
MousePheno	abnormal embryonic tissue cell apoptosis	USP17L2 USP17L15 NOTCH2 USP17L13	5.61e-04	180	30	4	MP:0013503
MousePheno	abnormal sex determination	USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	6.50e-04	945	30	8	MP:0002210
MousePheno	semilunar valve regurgitation	GALNT1 CTSV	6.67e-04	18	30	2	MP:0006049
MousePheno	failure of zygotic cell division	AMBP HMCN1	7.44e-04	19	30	2	MP:0003406
MousePheno	abnormal hair follicle orientation	GK5 CTSV	7.44e-04	19	30	2	MP:0000383
MousePheno	decreased basophil cell number	GALNT1 KIT	8.26e-04	20	30	2	MP:0002607
MousePheno	abnormal CD8-positive, alpha-beta T cell number	USP17L2 GK5 CTSV USP17L15 USP17L13	8.35e-04	352	30	5	MP:0008077
MousePheno	abnormal thymus size	NAA25 USP17L2 APEX2 CTSV USP17L15 USP17L13	1.09e-03	564	30	6	MP:0002364
MousePheno	abnormal male reproductive gland morphology	GPR155 USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	1.13e-03	1290	30	9	MP:0013325
MousePheno	abnormal CD8-positive, alpha beta T cell morphology	USP17L2 GK5 CTSV USP17L15 USP17L13	1.16e-03	379	30	5	MP:0005010
MousePheno	decreased B cell number	TET2 GALNT1 APEX2 KIT NOTCH2	1.38e-03	394	30	5	MP:0005017
MousePheno	cardiac valve regurgitation	GALNT1 CTSV	1.40e-03	26	30	2	MP:0009384
MousePheno	decreased leukocyte cell number	TET2 USP17L2 GALNT1 APEX2 KIT CTSV USP17L15 NOTCH2 USP17L13	1.50e-03	1342	30	9	MP:0000221
MousePheno	failure of blastocyst to hatch from the zona pellucida	USP17L2 USP17L15 USP17L13	1.52e-03	107	30	3	MP:0003694
MousePheno	abnormal testis morphology	USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	1.57e-03	1081	30	8	MP:0001146
MousePheno	increased CD4-positive, alpha-beta T cell number	USP17L2 CTSV USP17L15 USP17L13	1.66e-03	241	30	4	MP:0008074
MousePheno	abnormal blastocyst hatching	USP17L2 USP17L15 USP17L13	1.78e-03	113	30	3	MP:0003693
MousePheno	abnormal heart valve physiology	GALNT1 CTSV	1.87e-03	30	30	2	MP:0011926
MousePheno	alopecia	GK5 KIT CTSV	1.92e-03	116	30	3	MP:0000414
MousePheno	abnormal internal male genitalia morphology	GPR155 USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	1.94e-03	1392	30	9	MP:0009205
MousePheno	abnormal vitreous body morphology	EPPIN ZNF423 GALNT13 NOTCH2 ADGRL4	2.01e-03	429	30	5	MP:0002699
MousePheno	abnormal male genitalia morphology	GPR155 USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	2.17e-03	1415	30	9	MP:0009198
MousePheno	abnormal male reproductive system morphology	GPR155 USP17L2 EPPIN NKX2-1 FNDC3A KIT CTSV USP17L15 USP17L13	2.17e-03	1415	30	9	MP:0001145
Domain	HABP4_PAI-RBP1	USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	3.67e-32	16	50	13	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L21 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L19 USP17L22 USP17L13 USP17L18	3.67e-32	16	50	13	IPR006861
Domain	UCH	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	8.15e-30	71	50	17	PF00443
Domain	USP_2	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	8.15e-30	71	50	17	PS00973
Domain	USP_3	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.07e-29	72	50	17	PS50235
Domain	USP_dom	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.07e-29	72	50	17	IPR028889
Domain	Peptidase_C19_UCH	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.07e-29	72	50	17	IPR001394
Domain	USP_CS	USP17L21 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	3.71e-28	66	50	16	IPR018200
Domain	USP_1	USP17L21 USP17L4 USP17L2 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L8 USP17L13 USP17L18	1.07e-27	70	50	16	PS00972
Domain	EGF_CA	BMP1 HMCN1 NOTCH2 ADGRL4	8.21e-05	86	50	4	PF07645
Domain	Peptidase_M12A	MEP1A BMP1	1.05e-04	6	50	2	IPR001506
Domain	Astacin	MEP1A BMP1	1.05e-04	6	50	2	PF01400
Domain	EGF_Ca-bd_CS	BMP1 HMCN1 NOTCH2 ADGRL4	1.31e-04	97	50	4	IPR018097
Domain	EGF_CA	BMP1 HMCN1 NOTCH2 ADGRL4	1.42e-04	99	50	4	PS01187
Domain	ASX_HYDROXYL	BMP1 HMCN1 NOTCH2 ADGRL4	1.47e-04	100	50	4	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	BMP1 HMCN1 NOTCH2 ADGRL4	1.85e-04	106	50	4	IPR000152
Domain	EGF_CA	BMP1 HMCN1 NOTCH2 ADGRL4	3.16e-04	122	50	4	SM00179
Domain	EGF-like_Ca-bd_dom	BMP1 HMCN1 NOTCH2 ADGRL4	3.37e-04	124	50	4	IPR001881
Domain	EGF	MEP1A BMP1 HMCN1 NOTCH2	3.58e-04	126	50	4	PF00008
Domain	-	HMCN1 ADGRL4	3.80e-04	11	50	2	2.40.155.10
Domain	GFP-like	HMCN1 ADGRL4	3.80e-04	11	50	2	IPR023413
Domain	EGF_3	MEP1A BMP1 HMCN1 NOTCH2 ADGRL4	4.04e-04	235	50	5	PS50026
Domain	EGF	MEP1A BMP1 HMCN1 NOTCH2 ADGRL4	4.04e-04	235	50	5	SM00181
Domain	EGF-like_dom	MEP1A BMP1 HMCN1 NOTCH2 ADGRL4	5.25e-04	249	50	5	IPR000742
Domain	EGF-like_CS	MEP1A BMP1 HMCN1 NOTCH2 ADGRL4	6.50e-04	261	50	5	IPR013032
Domain	EGF_2	MEP1A BMP1 HMCN1 NOTCH2 ADGRL4	6.97e-04	265	50	5	PS01186
Domain	Prtase_inh_Kunz-CS	AMBP EPPIN	1.05e-03	18	50	2	IPR020901
Domain	KU	AMBP EPPIN	1.05e-03	18	50	2	SM00131
Domain	BPTI_KUNITZ_2	AMBP EPPIN	1.17e-03	19	50	2	PS50279
Domain	Kunitz_BPTI	AMBP EPPIN	1.17e-03	19	50	2	PF00014
Domain	BPTI_KUNITZ_1	AMBP EPPIN	1.17e-03	19	50	2	PS00280
Domain	Kunitz_BPTI	AMBP EPPIN	1.71e-03	23	50	2	IPR002223
Domain	Ricin_B_lectin	GALNT1 GALNT13	2.03e-03	25	50	2	PF00652
Domain	RICIN	GALNT1 GALNT13	2.54e-03	28	50	2	SM00458
Domain	RICIN_B_LECTIN	GALNT1 GALNT13	2.54e-03	28	50	2	PS50231
Domain	ZnMc	MEP1A BMP1	2.72e-03	29	50	2	SM00235
Domain	Peptidase_Metallo	MEP1A BMP1	2.72e-03	29	50	2	IPR006026
Domain	Ricin_B_lectin	GALNT1 GALNT13	2.91e-03	30	50	2	IPR000772
Domain	Glycos_transf_2	GALNT1 GALNT13	2.91e-03	30	50	2	PF00535
Domain	Glyco_trans_2-like	GALNT1 GALNT13	2.91e-03	30	50	2	IPR001173
Domain	EGF_1	MEP1A BMP1 HMCN1 NOTCH2	4.78e-03	255	50	4	PS00022
Domain	Growth_fac_rcpt_	BMP1 HMCN1 NOTCH2	8.41e-03	156	50	3	IPR009030
Domain	SCAN	ZSCAN32 ZKSCAN8	9.86e-03	56	50	2	SM00431
Domain	SCAN_BOX	ZSCAN32 ZKSCAN8	1.06e-02	58	50	2	PS50804
Domain	SCAN	ZSCAN32 ZKSCAN8	1.06e-02	58	50	2	PF02023
Domain	SCAN_dom	ZSCAN32 ZKSCAN8	1.06e-02	58	50	2	IPR003309
Domain	Retrov_capsid_C	ZSCAN32 ZKSCAN8	1.09e-02	59	50	2	IPR008916
Pathway	REACTOME_RAS_PROCESSING	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.26e-35	45	44	18	MM15671
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	7.95e-23	191	44	18	MM15289
Pathway	REACTOME_UB_SPECIFIC_PROCESSING_PROTEASES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.17e-21	221	44	18	M27578
Pathway	REACTOME_MAPK_FAMILY_SIGNALING_CASCADES	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 KIT USP17L15 USP17L8 USP17L13 USP17L18	2.55e-20	318	44	19	MM15278
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.61e-20	262	44	18	MM15286
Pathway	REACTOME_DEUBIQUITINATION	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.84e-19	299	44	18	M27574
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L4 USP17L2 GALNT1 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 LYPD5 USP17L6P USP17L3 USP17L5 USP17L10 MUC5B USP17L19 USP17L22 USP17L15 GALNT13 USP17L8 USP17L13 USP17L18	1.53e-11	1389	44	22	MM15307
Pathway	REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION	USP17L21 USP17L4 USP17L2 GALNT1 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 LYPD5 USP17L24 USP17L3 USP17L5 USP17L10 MUC5B USP17L19 USP17L22 USP17L15 GALNT13 USP17L8 USP17L13 USP17L18	5.04e-11	1475	44	22	M19806
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	GALNT1 MUC5B GALNT13	8.57e-04	60	44	3	MM15636
Pathway	REACTOME_O_LINKED_GLYCOSYLATION_OF_MUCINS	GALNT1 MUC5B GALNT13	9.44e-04	62	44	3	M546
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.94e-50	21	53	18	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.94e-50	21	53	18	14583620
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.94e-50	21	53	18	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.94e-50	21	53	18	8756639
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.94e-50	21	53	18	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	9.94e-50	21	53	18	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.46e-49	22	53	18	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.00e-47	24	53	18	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.58e-47	25	53	18	21115691
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	6.10e-47	33	53	19	20228807
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.16e-46	26	53	18	35816173
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	20403174
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	17109758
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	14699124
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	15780755
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	19188362
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	11941478
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.38e-46	34	53	19	21448158
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.02e-46	35	53	19	16611142
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.02e-46	35	53	19	21239494
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	6.39e-46	36	53	19	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.31e-45	37	53	19	20228808
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	2.57e-45	29	53	18	32527007
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.31e-39	50	53	18	31806660
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	TET2 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 APEX2 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.71e-21	674	53	20	37196079
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	1.51e-18	10	53	7	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	9.95e-18	12	53	7	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	4.30e-17	14	53	7	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	6.28e-16	19	53	7	28067227
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L4 USP17L2 USP17L1 USP17L6P USP17L3 USP17L15 USP17L8	4.03e-11	81	53	7	12838346
Pubmed	A Genome-Wide CRISPR Screen Identifies Genes Critical for Resistance to FLT3 Inhibitor AC220.	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	6.21e-10	119	53	7	28625976
Pubmed	Embryonic demise caused by targeted disruption of a cysteine protease Dub-2.	USP17L2 USP17L15 USP17L13	1.34e-08	4	53	3	22984479
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L4 USP17L1 USP17L3 USP17L8	8.90e-07	48	53	4	16421571
Pubmed	Diagnostic and prognostic significances of MUC5B and TTF-1 expressions in resected non-small cell lung cancer.	NKX2-1 MUC5B	2.28e-06	2	53	2	25733373
Pubmed	Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation.	TET2 KIT	2.28e-06	2	53	2	29364877
Pubmed	Revisiting the human polypeptide GalNAc-T1 and T13 paralogs.	GALNT1 GALNT13	2.28e-06	2	53	2	27913570
Pubmed	Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia.	TET2 KMT2C	2.28e-06	2	53	2	26880370
Pubmed	Next-generation sequencing with a myeloid gene panel in core-binding factor AML showed KIT activation loop and TET2 mutations predictive of outcome.	TET2 KIT	2.28e-06	2	53	2	27391574
Pubmed	In aggressive forms of mastocytosis, TET2 loss cooperates with c-KITD816V to transform mast cells.	TET2 KIT	2.28e-06	2	53	2	23074272
Pubmed	Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.	TET2 KIT	2.28e-06	2	53	2	24788138
Pubmed	Loss of epigenetic regulator TET2 and oncogenic KIT regulate myeloid cell transformation via PI3K pathway.	TET2 KIT	2.28e-06	2	53	2	29467326
Pubmed	Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine.	KIT NOTCH2	2.28e-06	2	53	2	20971948
Pubmed	Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.	AMBP GALNT1 GALNT13	6.61e-06	24	53	3	31740596
Pubmed	Polypeptide N-Acetylgalactosaminyltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin.	GALNT1 GALNT13	6.83e-06	3	53	2	27629416
Pubmed	The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.	NKX2-1 MUC5B	6.83e-06	3	53	2	21126317
Pubmed	Diabetic nephropathy induces changes in the proteome of human urinary exosomes as revealed by label-free comparative analysis.	AMBP KMT2C	6.83e-06	3	53	2	24211404
Pubmed	Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.	GALNT1 GALNT13	6.83e-06	3	53	2	12407114
Pubmed	UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family tree.	GALNT1 GALNT13	2.27e-05	5	53	2	22186971
Pubmed	Expression of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase isoforms in murine tissues determined by real-time PCR: a new view of a large family.	GALNT1 GALNT13	2.27e-05	5	53	2	12651884
Pubmed	Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.	NKX2-1 MUC5B NOTCH2	3.42e-05	41	53	3	22675208
Pubmed	Notch pathway activation targets AML-initiating cell homeostasis and differentiation.	TET2 NOTCH2	4.76e-05	7	53	2	23359070
Pubmed	British Society of Audiology short papers meeting on experimental studies of hearing and deafness. Cambridge, United Kingdom, 22-23 September 1996. Abstracts.	AMBP KIT	1.49e-04	12	53	2	9183385
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	KIT NOTCH2	1.76e-04	13	53	2	20558824
Pubmed	Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences.	NKX2-1 ZSWIM5	1.76e-04	13	53	2	18799682
Pubmed	Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways.	NKX2-1 MUC5B	2.05e-04	14	53	2	22797898
Pubmed	Large-scale genotyping identifies 41 new loci associated with breast cancer risk.	TET2 LYPD5 N4BP2L2	2.17e-04	76	53	3	23535729
Pubmed	Lunatic fringe null female mice are infertile due to defects in meiotic maturation.	KIT NOTCH2	3.43e-04	18	53	2	15659488
Pubmed	Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity.	NKX2-1 NOTCH2	3.43e-04	18	53	2	27364009
Pubmed	Notch/Rbpjκ signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons.	NKX2-1 NOTCH2	3.43e-04	18	53	2	23884446
Pubmed	Tracheal separation is driven by NKX2-1-mediated repression of Efnb2 and regulation of endodermal cell sorting.	NKX2-1 MUC5B	3.83e-04	19	53	2	35294885
Pubmed	The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.	KMT2C NKX2-1	4.25e-04	20	53	2	33431871
Pubmed	Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.	GALNT1 GALNT13	5.16e-04	22	53	2	25107907
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	GPR155 STRN USP17L23 USP17L5 GALNT13	5.63e-04	442	53	5	15815621
Pubmed	The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation.	NKX2-1 NOTCH2	5.65e-04	23	53	2	25505333
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT1 GALNT13	6.16e-04	24	53	2	31882545
Pubmed	Robo1 modulates proliferation and neurogenesis in the developing neocortex.	ZNF423 NOTCH2	7.80e-04	27	53	2	24741061
Pubmed	Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.	NKX2-1 NOTCH2	7.80e-04	27	53	2	35303432
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KMT2C APEX2 OBSCN HERC1 THOC3	9.53e-04	497	53	5	36774506
Pubmed	Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk.	NAA25 NOTCH2	1.17e-03	33	53	2	20203524
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	STRN OBSCN FNDC3A FLG2	1.20e-03	304	53	4	32235678
Pubmed	Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation.	NKX2-1 MUC5B	1.31e-03	35	53	2	18374910
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TET2 NAA25 ZNF423 N4BP2L2 NOTCH2	1.33e-03	536	53	5	15840001
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TET2 NAA25 ZNF423 N4BP2L2 NOTCH2	1.35e-03	538	53	5	10512203
Pubmed	Galnt1 is required for normal heart valve development and cardiac function.	GALNT1 GALNT13	1.39e-03	36	53	2	25615642
Interaction	FLT3 interactions	USP17L21 USP17L12 USP17L17 USP17L20 USP17L11 USP17L19 USP17L18	9.64e-06	318	48	7	int:FLT3
Cytoband	4p16.1	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	4.96e-30	79	53	15	4p16.1
Cytoband	Ensembl 112 genes in cytogenetic band chr4p16	USP17L21 USP17L23 USP17L12 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L13 USP17L18	6.08e-23	222	53	15	chr4p16
Cytoband	8p23.1	USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	1.00e-06	154	53	5	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L4 USP17L2 USP17L1 USP17L3 USP17L8	7.75e-06	234	53	5	chr8p23
GeneFamily	Bone morphogenetic proteins\|Astacins	MEP1A BMP1	4.25e-05	6	31	2	894
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT1 GALNT13	5.30e-04	20	31	2	433
Coexpression	MADAN_DPPA4_TARGETS	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	7.41e-33	86	51	18	MM1312
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_DN	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.34e-30	112	51	18	MM1095
Coexpression	GERY_CEBP_TARGETS	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.21e-27	160	51	18	MM1155
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	BMP1 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.11e-18	647	51	19	MM981
Coexpression	GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP	BMP1 USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 HERC1 USP17L22 CTSV USP17L15 USP17L8 USP17L13 USP17L18	2.97e-15	1226	51	21	MM979
Coexpression	MARSON_BOUND_BY_FOXP3_STIMULATED	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 HERC1 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	5.02e-14	1072	51	19	MM1031
Coexpression	BRUINS_UVC_RESPONSE_LATE	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	4.44e-12	1198	51	18	MM1062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 OBSCN MUC5B GALNT13	3.54e-05	184	45	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 OBSCN MUC5B GALNT13	3.54e-05	184	45	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HMCN1 OBSCN MUC5B GALNT13	3.54e-05	184	45	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BMP1 NKX2-1 GK5 GALNT13	3.61e-05	185	45	4	fefaf227d89f680d6f3e91c4a94e26ab4d0dc6c3
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Activated_Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMCN1 ZNF423 KIT ADGRL4	4.18e-05	192	45	4	0aeb5351275c0a91151ea2d52b2cdde172da6731
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMCN1 ZNF423 KIT ADGRL4	4.26e-05	193	45	4	6e1982d089a9de628e6006d23ff78a223fbd9f47
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HMCN1 ZNF423 KIT ADGRL4	4.35e-05	194	45	4	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	AT2_cells-IPF_03\|World / lung cells shred on cell class, cell subclass, sample id	GALNT1 HMCN1 NKX2-1 MUC5B	4.62e-05	197	45	4	5e0d222872a25bb9e9069d3dffda2844bb69874a
ToppCell	Bronchial_Brush-Epithelial-Basal_1\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	GPR155 HMCN1 NKX2-1 CTSV	4.62e-05	197	45	4	f5d87824c0020c95d89e069fd9f70b49e5d5fcea
ToppCell	Bronchial_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	GPR155 HMCN1 NKX2-1 CTSV	4.71e-05	198	45	4	10a17d7c116dcd6cf847fe6f5d7196d887cad1f9
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L21 USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	1.10e-42	46	49	19	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L21 KMT2C USP17L4 USP17L2 USP17L12 USP17L1 USP17L17 USP17L20 USP17L11 USP17L24 USP17L6P USP17L3 USP17L5 USP17L10 USP17L19 USP17L22 USP17L15 USP17L8 USP17L13 USP17L18	3.05e-41	69	49	20	DOID:1682 (implicated_via_orthology)
Disease	Systemic mastocytosis with associated clonal, hematologic non-mast-cell lineage disease	TET2 KIT	1.62e-05	4	49	2	C1301365
Disease	Leukemia, Myelocytic, Acute	TET2 KMT2C KIT NOTCH2	1.97e-04	173	49	4	C0023467
Disease	Sezary Syndrome	TET2 KMT2C	9.23e-04	27	49	2	C0036920
Disease	hemoglobin A1 measurement	TET2 GPR155 STRN NAA25 NOTCH2	1.68e-03	520	49	5	EFO_0007629
Disease	Neoplasm Recurrence, Local	TET2 KIT	1.92e-03	39	49	2	C0027643
Disease	Carcinoma, Transitional Cell	AMBP KMT2C	2.13e-03	41	49	2	C0007138
Disease	esophagus squamous cell carcinoma (is_implicated_in)	TET2 KMT2C	2.56e-03	45	49	2	DOID:3748 (is_implicated_in)
Disease	Acute Promyelocytic Leukemia	TET2 KIT	2.67e-03	46	49	2	C0023487

Protein segments in the cluster

Peptide	Gene	Start	Entry
ACYCNMGFSGNGVTI	ADGRL4	41	Q9HBW9
CETFQYGGCMGNGNN	AMBP	256	P02760
YGGCMGNGNNFVTEK	AMBP	261	P02760
QGCNGGFMARAFQYV	CTSV	176	O60911
QNGDVGCYGNMDEFT	APEX2	106	Q9UBZ4
NGGCQQDCVNTFGSY	BMP1	711	P13497
GQMCGLCGNFNQNQA	MUC5B	556	Q9HC84
SAVGGYCNGNLGNMS	NKX2-1	81	P43699
QSMYVFGGCTQSSCN	FBXO42	131	Q6P3S6
QNGGSCMDGVNTFSC	NOTCH2	921	Q04721
QGNQFSYIQSGCQSG	FLG2	306	Q5D862
NQDMCVVCGSFGQGA	KMT2C	956	Q8NEZ4
GVFMCYANNTFGSAN	KIT	286	P10721
CMNQTAQAGSYEGFD	GPR155	541	Q7Z3F1
VYAWGNNSMGQCGQG	HERC1	686	Q15751
AFGGSYCDGAETQMQ	HMCN1	4676	Q96RW7
FNCHGMGGNQVFSYT	GALNT13	456	Q8IUC8
DSGQYMCFAASAAGN	OBSCN	6081	Q5VST9
IFNCHGMGGNQVFSY	GALNT1	456	Q10472
GKGNGEFCQCYMGSQ	FNDC3A	411	Q9Y2H6
TACFQGNGRMTVGNF	LYPD5	161	Q6UWN5
QQSAMFGECCFQTGD	GK5	276	Q6ZS86
MSCPNYCSGNSNSGS	KRTAP26-1	1	Q6PEX3
TCSMFVYGGCQGNNN	EPPIN	101	O95925
CVVMSSNGEQCYSGG	STRN	521	O43815
GQCTGAGYFMQFSTS	MEP1A	306	Q16819
AAVGAGLQNMGNTCY	USP17L3	76	A6NCW0
QGGYCGSGKQLNSMF	ZSWIM5	351	Q9P217
PYQCGQCGKSFNQSS	ZSCAN32	576	Q9NX65
AAVGAGLQNMGNTCY	USP17L4	76	A6NCW7
AAVGAGLQNMGNTCY	USP17L18	76	D6R9N7
NNDNNMFFLTNGNGC	THOC3	191	Q96J01
AAVGAGLQNMGNTCY	USP17L5	76	A8MUK1
AAVGAGLQNMGNTCY	USP17L21	76	D6R901
AAVGAGLQNMGNTCY	USP17L13	76	C9JLJ4
AAVGAGLQNMGNTCY	USP17L19	76	D6RCP7
AAVGAGLQNMGNTCY	USP17L1	76	Q7RTZ2
AAVGAGLQNMGNTCY	USP17L12	76	C9JPN9
AAVGAGLQNMGNTCY	USP17L24	76	Q0WX57
AAVGAGLQNMGNTCY	USP17L8	76	P0C7I0
SDGNNAFFCNQCSMG	ZNF423	511	Q2M1K9
AAVGAGLQNMGNTCY	USP17L6P	76	Q6QN14
AAVGAGLQNMGNTCY	USP17L22	76	D6RA61
YGNQNMQGDGFSSCT	TET2	1696	Q6N021
AAVGAGLQNMGNTCY	USP17L15	76	C9J2P7
AAVGAGLQNMGNTCY	USP17L17	76	D6RBQ6
AAVGAGLQNMGNTCY	USP17L23	76	D6RBM5
AAVGAGLQNMGNTCY	USP17L2	76	Q6R6M4
AAVGAGLQNMGNTCY	USP17L20	76	D6RJB6
YQCNQCGKAFSQSAG	ZKSCAN8	406	Q15776
AAVGAGLQNMGNTCY	USP17L10	76	C9JJH3
AAVGAGLQNMGNTCY	USP17L11	76	C9JVI0
GNGCSMQDRYVSNGF	N4BP2L2	351	Q92802
MGGFFNSGCSQCQIS	NAA25	761	Q14CX7