Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
HumanPheno	Square-wave jerks	SYNE1 VPS13A	5.84e-05	3	23	2	HP:0025402
HumanPheno	Saccadic intrusion	SYNE1 VPS13A	5.84e-05	3	23	2	HP:0032114
Domain	Elf-1_N	ELF2 ELF4	3.79e-05	3	67	2	PF12310
Domain	TF_Elf_N	ELF2 ELF4	3.79e-05	3	67	2	IPR022084
Domain	CABIT	GAREM2 GAREM1	7.57e-05	4	67	2	PF12736
Domain	CABIT_dom	GAREM2 GAREM1	7.57e-05	4	67	2	IPR025946
Domain	MHC_I	ULBP1 RAET1L	2.55e-03	21	67	2	PF00129
Domain	MHC_I_a_a1/a2	ULBP1 RAET1L	2.55e-03	21	67	2	IPR001039
Domain	-	ULBP1 RAET1L	3.33e-03	24	67	2	3.30.500.10
Domain	MHC_I-like_Ag-recog	ULBP1 RAET1L	3.33e-03	24	67	2	IPR011161
Domain	SMALL_CYTOKINES_CC	CCL28 CCL11	3.90e-03	26	67	2	PS00472
Domain	Chemokine_CC_CS	CCL28 CCL11	3.90e-03	26	67	2	IPR000827
Domain	ETS_DOMAIN_1	ELF2 ELF4	4.51e-03	28	67	2	PS00345
Domain	ETS_DOMAIN_2	ELF2 ELF4	4.51e-03	28	67	2	PS00346
Domain	ETS	ELF2 ELF4	4.51e-03	28	67	2	SM00413
Domain	Ets_dom	ELF2 ELF4	4.51e-03	28	67	2	IPR000418
Domain	ETS_DOMAIN_3	ELF2 ELF4	4.51e-03	28	67	2	PS50061
Domain	Ets	ELF2 ELF4	4.51e-03	28	67	2	PF00178
Pubmed	The amino acid sensor GCN2 suppresses terminal oligopyrimidine (TOP) mRNA translation via La-related protein 1 (LARP1).	LARP1 EIF2AK4	3.99e-06	2	70	2	35863436
Pubmed	Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).	ZEB1 IDH2	1.20e-05	3	70	2	23038259
Pubmed	Targeted ubiquitination and degradation of G-protein-coupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex.	CKAP5 AP3M2 LARP1 OLA1 LYAR	1.63e-05	156	70	5	22952844
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	CASP8AP2 KDM5B ZEB1 ZNF532 RAB3GAP2 CKAP5 KNL1	2.15e-05	418	70	7	34709266
Pubmed	A brain-specific Grb2-associated regulator of extracellular signal-regulated kinase (Erk)/mitogen-activated protein kinase (MAPK) (GAREM) subtype, GAREM2, contributes to neurite outgrowth of neuroblastoma cells by regulating Erk signaling.	GAREM2 GAREM1	2.39e-05	4	70	2	24003223
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	DHX36 STRN PACSIN1 PTPRS SYNE1 MYO18A CKAP5 LARP1 MICAL3 IDH2 OLA1 DYNC1I1	2.62e-05	1431	70	12	37142655
Pubmed	MULT1E/mIL-12: a novel bifunctional protein for natural killer cell activation.	ULBP1 RAET1L	3.98e-05	5	70	2	24572784
Pubmed	Interleukin-1 receptor accessory protein organizes neuronal synaptogenesis as a cell adhesion molecule.	PTPRS IL1RAP	3.98e-05	5	70	2	22357843
Pubmed	Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.	ELF2 ELF4	3.98e-05	5	70	2	10207087
Pubmed	Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.	DHX36 SYNE1 CKAP5 LARP1 LYAR DDX24	5.67e-05	332	70	6	25693804
Pubmed	Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations.	ULBP1 RAET1L	5.96e-05	6	70	2	20219610
Pubmed	Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.	ELF2 ELF4	5.96e-05	6	70	2	14970218
Pubmed	Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais.	ULBP1 RAET1L	5.96e-05	6	70	2	19688209
Pubmed	eIF2α phosphorylation controls thermal nociception.	ELF2 EIF2AK4	5.96e-05	6	70	2	27698114
Pubmed	The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60.	ULBP1 RAET1L	8.33e-05	7	70	2	16831899
Pubmed	Stress-regulated targeting of the NKG2D ligand Mult1 by a membrane-associated RING-CH family E3 ligase.	ULBP1 RAET1L	8.33e-05	7	70	2	20870941
Pubmed	Critical role of the NKG2D receptor for NK cell-mediated control and immune escape of B-cell lymphoma.	ULBP1 RAET1L	8.33e-05	7	70	2	26151313
Pubmed	NKG2D and Its Ligand MULT1 Contribute to Disease Progression in a Mouse Model of Multiple Sclerosis.	ULBP1 RAET1L	8.33e-05	7	70	2	30787931
Pubmed	Cutting edge: murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.	ULBP1 RAET1L	8.33e-05	7	70	2	12370332
Pubmed	NKG2D ligand overexpression in lupus nephritis correlates with increased NK cell activity and differentiation in kidneys but not in the periphery.	ULBP1 RAET1L	8.33e-05	7	70	2	25583577
Pubmed	A disease-linked ULBP6 polymorphism inhibits NKG2D-mediated target cell killing by enhancing the stability of NKG2D ligand binding.	ULBP1 RAET1L	8.33e-05	7	70	2	28559451
Pubmed	The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival.	DHX36 LARP1 OLA1 LYAR DDX24	8.38e-05	220	70	5	31822558
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	CASP8AP2 PACSIN1 SYNE1 RAB3GAP2 RNF10	9.32e-05	225	70	5	12168954
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DHX36 CASP8AP2 ZNF532 PACSIN1 RNF10 LARP1 EIF2AK4	9.49e-05	529	70	7	14621295
Pubmed	A novel ligand for the NKG2D receptor activates NK cells and macrophages and induces tumor immunity.	ULBP1 RAET1L	1.11e-04	8	70	2	12645935
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	DHX36 AIMP2 MYO18A CKAP5 LARP1 ERI1 LYAR DDX24	1.42e-04	759	70	8	35915203
Pubmed	Gut microbiota regulates NKG2D ligand expression on intestinal epithelial cells.	ULBP1 RAET1L	1.42e-04	9	70	2	23136011
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CDO1 ZEB1 MYO18A CKAP5 LARP1 ELF2 MICAL3 DDX24	1.62e-04	774	70	8	15302935
Pubmed	A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3.	ULBP1 RAET1L	1.78e-04	10	70	2	11827464
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	DHX36 CDO1 STRN PTPRS RAB3GAP2 LARP1 OLA1 LYAR BIN3 DDX24	2.41e-04	1284	70	10	17353931
Pubmed	A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components.	GAREM2 SYNE1 DYNC1I1	2.46e-04	60	70	3	20682791
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CASP8AP2 CCL28 ULBP1 RAET1L CCL11 IL1RAP DDX24 IL17RB	2.48e-04	824	70	8	20237496
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CASP8AP2 PACSIN1 MICAL3 EIF2AK4	2.63e-04	153	70	4	10718198
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	DHX36 AIMP2 DHFR LARP1 OLA1	2.71e-04	283	70	5	28533407
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	DHX36 KDM5B ZNF532 SYNE1 MYO18A IDH2 LYAR DDX24 ZC3H6	3.13e-04	1082	70	9	38697112
Pubmed	A human MAP kinase interactome.	CASP8AP2 PACSIN1 SYNE1 MYO18A PIBF1 GAREM1	4.45e-04	486	70	6	20936779
Pubmed	A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.	MGAT2 CLGN PRIM2 DHFR MICAL3 IDH2 DDX24	4.60e-04	686	70	7	28380382
Pubmed	Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells.	AIMP2 PACSIN1 RNF10 LYAR DDX24	5.45e-04	330	70	5	21044950
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	STRN FAM186A SYNE1 AVIL VPS13A MYO18A LARP1 DLEC1 EIF2AK4 DYNC1I1	5.99e-04	1442	70	10	35575683
Pubmed	Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.	PGS1 PACSIN1 OLA1 LYAR DDX24 PASD1	6.53e-04	523	70	6	11256614
Pubmed	Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome.	STRN DHFR MICAL3 GABRA2	6.84e-04	197	70	4	36604605
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MYO18A CKAP5 LARP1 EIF2AK4	7.51e-04	202	70	4	33005030
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	PRIM2 CKAP5 LYAR DDX24	8.98e-04	212	70	4	33462405
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	DHX36 CLGN TRPM7 CKAP5 LARP1	9.67e-04	375	70	5	32788342
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	AVIL GABRA2	9.83e-04	23	70	2	34473953
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	ELF2 ELF4	1.07e-03	24	70	2	22056786
Pubmed	A conserved acetylation switch enables pharmacological control of tubby-like protein stability.	STRN RAB3GAP2 AP3M2 TRIP4	1.08e-03	223	70	4	33187986
Pubmed	Defects in the cappuccino (cno) gene on mouse chromosome 5 and human 4p cause Hermansky-Pudlak syndrome by an AP-3-independent mechanism.	CDO1 AP3M2	1.16e-03	25	70	2	11110696
Pubmed	Developmental abnormalities in cortical GABAergic system in mice lacking mGlu3 metabotropic glutamate receptors.	DLX2 GABRA2	1.16e-03	25	70	2	31665922
Pubmed	Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex.	DHX36 STRN CKAP5 LARP1 DDX24	1.27e-03	399	70	5	37536630
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	DHX36 MGAT2 TRPM7 RAB3GAP2 ELF2 CCL11 EIF2AK4 ERI1 OLA1	1.34e-03	1327	70	9	32694731
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	PACSIN1 SYNE1	1.36e-03	27	70	2	18649358
Pubmed	Molecular cloning and sequencing of 25 different rhesus macaque chemokine cDNAs reveals evolutionary conservation among C, CC, CXC, AND CX3C families of chemokines.	CCL28 CCL11	1.36e-03	27	70	2	12126650
Pubmed	Full function of exon junction complex factor, Rbm8a, is critical for interneuron development.	DLX2 GABRA2	1.46e-03	28	70	2	33154347
Pubmed	ETS-family genes in pancreatic development.	ELF2 ELF4	1.57e-03	29	70	2	17907201
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	ELF2 ELF4	1.57e-03	29	70	2	26097038
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	STRN CKAP5 MICAL3 LYAR PIBF1 BIN3 DYNC1I1	1.63e-03	853	70	7	28718761
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	DHX36 CKAP5 LARP1 LYAR	1.67e-03	251	70	4	28077445
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KDM5B TRPM7 RAB3GAP2 CKAP5 RNF10 LARP1 PIBF1	1.72e-03	861	70	7	36931259
Pubmed	Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.	ZEB1 DLX2	1.79e-03	31	70	2	23312518
Pubmed	Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening.	ZEB1 VPS13A	1.79e-03	31	70	2	32546759
Pubmed	The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression.	CASP8AP2 MYO18A ELF4	1.81e-03	119	70	3	24162774
Pubmed	Characterizing embryonic gene expression patterns in the mouse using nonredundant sequence-based selection.	KDM5B PTPRS	1.90e-03	32	70	2	14613977
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	LARP1 ELF2 ELF4	1.99e-03	123	70	3	26912792
Cytoband	6q25	SYNE1 ULBP1	1.50e-04	12	70	2	6q25
GeneFamily	Zinc fingers\|Zinc fingers PARP-type\|Poly(ADP-ribose) polymerases	LYAR TRIP4	4.68e-04	15	39	2	26
GeneFamily	ETS transcription factor family	ELF2 ELF4	1.65e-03	28	39	2	534
GeneFamily	CD molecules\|I-set domain containing\|Immunoglobulin like domain containing\|Interleukin receptors\|TIR domain containing	IL1RAP IL17RB	3.70e-03	42	39	2	602
GeneFamily	Chemokine ligands\|Endogenous ligands	CCL28 CCL11	4.23e-03	45	39	2	483
Coexpression	LAZARO_GENETIC_MOUSE_MODEL_HIGH_GRADE_LARGE_CELL_NEUROENDOCRINE_LUNG_CARCINOMA_UP	CASP8AP2 CCL28 PRIM2 DHFR ULBP1 RAET1L ERI1 KNL1	1.18e-05	402	70	8	MM454
Coexpression	GSE2405_S_AUREUS_VS_UNTREATED_NEUTROPHIL_UP	DHX36 KDM5B ULBP1 ELF2 ELF4 KYAT1	1.55e-05	199	70	6	M6192
Coexpression	DODD_NASOPHARYNGEAL_CARCINOMA_UP	CASP8AP2 ST20 AIMP2 ZNF532 TRPM7 PRIM2 DHFR CKAP5 AP3M2 EIF2AK4 ERI1 OLA1 LYAR KNL1	1.76e-05	1407	70	14	M14427
Coexpression	HOFMANN_MYELODYSPLASTIC_SYNDROM_LOW_RISK_UP	PTPRS DLEC1 IL1RAP	2.34e-05	21	70	3	M6868
Coexpression	ODONNELL_TFRC_TARGETS_UP	SLC10A1 CCL28 PTPRS SYNE1 RAB3GAP2 DLX2 FER1L5 DYNC1I1	2.36e-05	443	70	8	M6753
Coexpression	BENPORATH_CYCLING_GENES	CASP8AP2 KDM5B MGAT2 PRIM2 DHFR CKAP5 AP3M2 LARP1 LYAR	5.53e-05	648	70	9	M8156
Disease	Immune System Diseases	TRPM7 EIF2AK4	1.09e-04	7	68	2	C0021053
Disease	corpus callosum posterior volume measurement	STRN CFAP54 GAREM1	2.39e-04	52	68	3	EFO_0010298
Disease	obsolete_red blood cell distribution width	PGS1 STRN CCL28 GAREM2 VPS13A RNF10 LARP1 EIF2AK4 ERI1 PIBF1 KNL1	2.41e-04	1347	68	11	EFO_0005192
Disease	reticulocyte count	PGS1 STRN AIMP2 KCNU1 CCL28 VPS13A RNF10 LARP1 EIF2AK4	6.40e-04	1045	68	9	EFO_0007986
Disease	corpus callosum central volume measurement	STRN SLC9A2	1.90e-03	28	68	2	EFO_0010296
Disease	endometrial carcinoma	CASP8AP2 DLEC1 EIF2AK4	2.29e-03	113	68	3	EFO_1001512

Protein segments in the cluster

Peptide	Gene	Start	Entry
DTFPQVLKKVIDWMK	ERI1	201	Q8IV48
VKQWMKVQAAKKNGK	CCL28	81	Q9NRJ3
NWSVKGAVKEVMKFK	CFAP54	1316	Q96N23
FAALPGWKQLQMKKE	AVIL	801	O75366
QWQKKMGPFLTSQEK	EIF2AK4	316	Q9P2K8
EQQLPDMKKKLWKFV	CASP8AP2	1121	Q9UKL3
KFKKMWKSGEIPSEQ	DLX2	206	Q07687
MCKVKSWVIDQKKPV	OLA1	186	Q9NTK5
TKMLSWDVGKINPQK	AP3M2	336	P53677
VPKWKYSDKGKEEMQ	RAB3GAP2	101	Q9H2M9
KGNKHKWVPLQIDMK	LARP1	246	Q6PKG0
GKKDDPKLMQEWFKL	MICAL3	1886	Q7RTP6
PKLMQEWFKLVQEKN	MICAL3	1891	Q7RTP6
MKVLEFWAKVNKTVP	MAGEB3	286	O15480
VFKKMWKLKQQECPE	MGAT2	271	Q10469
AVSKLWGKQKNKPDM	ELF4	246	Q99607
GRFWKQLQVAMPVKK	IL1RAP	536	Q9NPH3
EKWQKKKIAEMGPVQ	IL17RB	366	Q9NRM6
EPDGVALVWNMKFKK	DYNC1I1	316	O14576
KWKDERLKFKGPMNI	GABRA2	96	P47869
VQKNIKKNKGVKDWP	MYO18A	1221	Q92614
VKLWVKMVTPLIKNF	PGS1	541	Q32NB8
QVKKIMQFINGWRPK	GAREM1	861	Q9H706
KPKFPKEKQNVKIWG	KNL1	861	Q8NG31
VEQNKKVMPKQTWKK	KCNU1	501	A8MYU2
KVMPKQTWKKHFLNS	KCNU1	506	A8MYU2
KWTKIATKMGFAPGK	KDM5B	151	Q9UGL1
EGKTQIMYKWIEPKI	ELAPOR2	361	A8MWY0
KPRVTWNKKGKKVNS	PTPRS	61	Q13332
RKKWQGQMLQKEPEE	PASD1	546	Q8IV76
EDGFRKAQKPWAKKM	PACSIN1	136	Q9BY11
MEFSKIKAHLWKPKG	SLC10A1	46	Q14973
FWKQEFIKGKMDPDK	PRIM2	326	P49643
KKPGWKETNFQVMQM	CKAP5	646	Q14008
FKLKKMWKSPNGTIR	IDH2	126	P48735
LFAWPDKKSNEMVKK	CDO1	106	Q16878
QLIDPWKFQRMKKVG	FNDC11	101	Q9BVV2
WKFQRMKKVGTAQTK	FNDC11	106	Q9BVV2
EIGMWYAKKQGQKNK	DHX36	61	Q9H2U1
VIMGKKTWFSIPEKN	DHFR	51	P00374
MSWIPFKIGQPKKQI	BIN3	1	Q9NQY0
VSKLWGKHKNKPDMN	ELF2	246	Q15723
NVPRKKAKFQNWMKN	LYAR	106	Q9NX58
KIIWLKNKMDIQGNP	MYBPHL	291	A2RUH7
VGKWKEVKIDPNMFA	DDX24	26	Q9GZR7
PVWITMAKQKQKSFK	KIAA1210	1576	Q9ULL0
GKKVMQVWTEKQKSL	FAM186A	2201	A6NE01
KKAFKMWNNSKSPIR	DLEC1	776	Q9Y238
TKLQVKKIMQFIKGW	GAREM2	856	Q75VX8
TLKMWNLQKTAPAKK	STRN	486	O43815
VAFQSMVKKTGDWKK	SYNE1	906	Q8NF91
GKVQMWVDIFPKKLG	FER1L5	1691	A0AVI2
FVKWMIKNKGLVAIP	KYAT1	366	Q16773
IAPGVSVKYWKKLMQ	WDR17	851	Q8IZU2
DKKMFKSVVKFGPWK	KCTD14	191	Q9BQ13
QIIATVKCKPWKMEK	TMC1	101	Q8TDI8
TLIWKNVPKTQMKFS	AIMP2	186	Q13155
PKKKWVQDSMKYLDQ	CCL11	76	P51671
WKIMIANANKPGVLK	CLGN	446	O14967
VKKSMETKKVASPGW	ZNF532	1011	Q9HCE3
DFQEYNKPGKKWKVM	ZC3H6	246	P61129
NKPGKKWKVMTQEFI	ZC3H6	251	P61129
DFRPWNLGIKMKKKA	VPS13A	1796	Q96RL7
KKSPQSYKMEWKNEV	SLC9A2	721	Q9UBY0
ENGFVKKLEPKSGWM	ST20	16	Q9HBF5
KRGDFLMWKENGKKP	SPATA31D1	421	Q6ZQQ2
KGVLVALPKSKWMNV	RNF10	301	Q8N5U6
FTKKEAPEWSKKQKM	PIBF1	741	Q8WXW3
PLGKKLNVTMAWKAQ	RAET1L	76	Q5VY80
PLDVVKKWFEKMQAG	ZEB1	621	P37275
LHPGAKKMTEKWEKN	ULBP1	161	Q9BZM6
EMVVKFPIKGNPKIW	TRIP4	546	Q15650
MSEAGKVNQKIKVWF	TRPM7	906	Q96QT4
KRMNIKPKKAWTKQN	LRRC51	176	Q96E66