Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2A KMT2D

2.94e-058212GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2A KMT2D

4.72e-0510212GO:0140999
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2A KMT2D

1.98e-0420212GO:0042800
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2A KMT2D

9.70e-0444212GO:0140938
GeneOntologyMolecularFunctionmethyltransferase activity

PRDM12 KMT2A KMT2D

1.38e-03213213GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

PRDM12 KMT2A KMT2D

1.60e-03224213GO:0016741
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2A KMT2D

2.30e-0368212GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2A KMT2D

2.37e-0369212GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2A KMT2D

2.51e-0371212GO:0042054
GeneOntologyMolecularFunctionprotein methyltransferase activity

KMT2A KMT2D

5.19e-03103212GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2A KMT2D

5.39e-03105212GO:0008170
HumanPhenoEversion of lateral third of lower eyelids

KMT2A KMT2D

1.15e-05652HP:0007655
MousePhenosmall cecum

NKX2-3 ZNF398

1.75e-055192MP:0009477
DomainFYrich_C

KMT2A KMT2D

1.20e-055212IPR003889
DomainFYrich_N

KMT2A KMT2D

1.20e-055212IPR003888
DomainFYRC

KMT2A KMT2D

1.20e-055212SM00542
DomainFYRN

KMT2A KMT2D

1.20e-055212SM00541
DomainFYRN

KMT2A KMT2D

1.20e-055212PF05964
DomainFYRC

KMT2A KMT2D

1.20e-055212PF05965
DomainFYRC

KMT2A KMT2D

1.20e-055212PS51543
DomainFYRN

KMT2A KMT2D

1.20e-055212PS51542
DomainSET

PRDM12 KMT2A KMT2D

1.80e-0546213SM00317
DomainSET_dom

PRDM12 KMT2A KMT2D

2.32e-0550213IPR001214
DomainSET

PRDM12 KMT2A KMT2D

2.32e-0550213PS50280
DomainPost-SET_dom

KMT2A KMT2D

1.43e-0416212IPR003616
DomainPostSET

KMT2A KMT2D

1.43e-0416212SM00508
DomainPOST_SET

KMT2A KMT2D

1.43e-0416212PS50868
DomainEPHD

KMT2A KMT2D

2.74e-0422212PS51805
DomainSET

KMT2A KMT2D

9.62e-0441212PF00856
DomainPHD

KMT2A KMT2D

3.18e-0375212PF00628
DomainZnf_PHD-finger

KMT2A KMT2D

3.52e-0379212IPR019787
DomainPHD

KMT2A KMT2D

4.45e-0389212SM00249
DomainZnf_PHD

KMT2A KMT2D

4.64e-0391212IPR001965
DomainZF_PHD_2

KMT2A KMT2D

5.05e-0395212PS50016
DomainZF_PHD_1

KMT2A KMT2D

5.15e-0396212PS01359
DomainZnf_FYVE_PHD

KMT2A KMT2D

1.17e-02147212IPR011011
PathwayWP_EGFEGFR_SIGNALING

CBLC RICTOR LIMK2

6.12e-04162153M39334
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2A KMT2D

7.27e-0438152MM17073
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2A KMT2D

8.88e-0442152M48018
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2A KMT2D

9.74e-0444152MM15527
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

KMT2A KMT2D

1.06e-0346152MM14933
Pubmed

Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo.

KMT2A KMT2D

3.47e-07221226711341
Pubmed

Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.

KMT2A KMT2D

3.47e-07221224423662
Pubmed

Pygo2 functions as a prognostic factor for glioma due to its up-regulation of H3K4me3 and promotion of MLL1/MLL2 complex recruitment.

KMT2A KMT2D

1.04e-06321226902498
Pubmed

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

KMT2A KMT2D

1.04e-06321230315824
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2A KMT2D

1.04e-06321223932714
Pubmed

MLL histone methylases regulate expression of HDLR-SR-B1 in presence of estrogen and control plasma cholesterol in vivo.

KMT2A KMT2D

1.04e-06321223192982
Pubmed

Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.

KMT2A KMT2D

2.08e-06421222863532
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2A KMT2D

2.08e-06421223129768
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2A KMT2D

2.08e-06421224081332
Pubmed

Oncogenic All1 fusion proteins target Drosha-mediated microRNA processing.

KMT2A DROSHA

2.08e-06421217581865
Pubmed

KDM5A noncanonically binds antagonists MLL1/2 to mediate gene regulation and promotes epithelial to mesenchymal transition.

KMT2A KMT2D

2.08e-06421237722486
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

KMT2A RICTOR KMT2D

2.31e-064321333472061
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2A KMT2D

3.47e-06521226320581
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2A KMT2D

3.47e-06521228609655
Pubmed

Combinatorial CRISPR screen identifies fitness effects of gene paralogues.

USP38 KMT2A LIMK2 UAP1

4.41e-0618621433637726
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2A KMT2D

5.20e-06621216199523
Pubmed

GRWD1-WDR5-MLL2 Epigenetic Complex Mediates H3K4me3 Mark and Is Essential for Kaposi's Sarcoma-Associated Herpesvirus-Induced Cellular Transformation.

KMT2A KMT2D

5.20e-06621234933446
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2A KMT2D

5.20e-06621224176642
Pubmed

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.

KMT2A KMT2D

7.28e-06721236598580
Pubmed

Matrix Metalloproteinase-9 gene induction by a truncated oncogenic NF-kappaB2 protein involves the recruitment of MLL1 and MLL2 H3K4 histone methyltransferase complexes.

KMT2A KMT2D

7.28e-06721219219072
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2A KMT2D

9.70e-06821223130995
Pubmed

The mutational landscape of lethal castration-resistant prostate cancer.

KMT2A KMT2D

9.70e-06821222722839
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2A KMT2D

9.70e-06821222266653
Pubmed

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

KMT2A KMT2D

1.25e-05921216951254
Pubmed

Physical Interactions and Functional Coordination between the Core Subunits of Set1/Mll Complexes and the Reprogramming Factors.

KMT2A KMT2D

1.25e-05921226691508
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2A KMT2D

1.25e-05921222665483
Pubmed

WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.

KMT2A KMT2D

1.25e-05921215960974
Pubmed

The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.

KMT2A KMT2D

1.25e-05921224930734
Pubmed

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney.

SCNN1G RICTOR

1.56e-051021221413931
Pubmed

Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.

KMT2A KMT2D

1.90e-051121218082152
Pubmed

Functional proteomics mapping of a human signaling pathway.

ZNF106 DROSHA LIMK2 RHOT2 KMT2D

2.26e-0559121515231748
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2A KMT2D

2.28e-051221227563068
Pubmed

The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.

KMT2A KMT2D

2.70e-051321216510874
Pubmed

Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.

KMT2A KMT2D

3.63e-051521216510875
Pubmed

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.

KMT2A KMT2D

3.63e-051521214992727
Pubmed

Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.

CBLC RICTOR

5.90e-051921231959764
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2A KMT2D

7.24e-052121227626377
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2A KMT2D

7.96e-052221226886794
Pubmed

MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.

KMT2A DROSHA RICTOR

8.05e-0514021320819778
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

CBLC KMT2A ZNF106 RICTOR KMT2D

8.16e-0577421515302935
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KMT2A ZNF106 RICTOR LIMK2 UAP1

1.34e-0486121536931259
Pubmed

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

KMT2A KMT2D

1.60e-043121215960975
Pubmed

A census of human transcription factors: function, expression and evolution.

NKX2-3 ZNF398 PRDM12 KMT2A KMT2D

1.72e-0490821519274049
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

KMT2A KMT2D

4.18e-045021237974198
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ADGRL2 DROSHA RICTOR LIMK2 RHOT2

4.47e-04111621531753913
Pubmed

New nomenclature for chromatin-modifying enzymes.

KMT2A KMT2D

5.43e-045721218022353
CytobandEnsembl 112 genes in cytogenetic band chr5p13

DROSHA RICTOR

2.02e-03139222chr5p13
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2A KMT2D

4.59e-0434172487
GeneFamilyPHD finger proteins

KMT2A KMT2D

3.17e-039017288
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF398 PRDM12 ZNF106

2.80e-0271817328
Diseaselung small cell carcinoma (is_implicated_in)

RICTOR KMT2D

1.98e-0428222DOID:5409 (is_implicated_in)
Diseaseselenium measurement

ADGRL2 ANKRD44

2.13e-0429222EFO_0006331
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

RICTOR KMT2D

5.15e-0445222DOID:3748 (is_implicated_in)
Diseasedimethylglycine measurement

ADGRL2 ANKRD44

5.38e-0446222EFO_0010476
DiseaseMale sterility

DROSHA KMT2D

5.86e-0448222C0917731
DiseaseMale infertility

DROSHA KMT2D

5.86e-0448222C0021364
DiseaseSubfertility, Male

DROSHA KMT2D

5.86e-0448222C0848676
DiseaseProstatic Neoplasms

KMT2A GRPR KMT2D NDST2

1.02e-03616224C0033578
DiseaseMalignant neoplasm of prostate

KMT2A GRPR KMT2D NDST2

1.02e-03616224C0376358
Diseasecongenital heart disease (implicated_via_orthology)

KMT2A KMT2D

1.21e-0369222DOID:1682 (implicated_via_orthology)
Diseaseautoimmune thyroid disease, systemic lupus erythematosus, type 1 diabetes mellitus, ankylosing spondylitis, psoriasis, common variable immunodeficiency, celiac disease, ulcerative colitis, Crohn's disease, autoimmune disease, juvenile idiopathic arthritis

ADGRL2 NKX2-3

1.24e-0370222EFO_0000384, EFO_0000676, EFO_0000729, EFO_0001060, EFO_0002609, EFO_0003898, EFO_0005140, EFO_0006812, MONDO_0005147, MONDO_0007915, MONDO_0015517
Diseasereaction time measurement

ADGRL2 ANKRD44 LIMK2 KMT2D

1.30e-03658224EFO_0008393
Diseaseesophagus squamous cell carcinoma (is_marker_for)

RICTOR KMT2D

1.39e-0374222DOID:3748 (is_marker_for)
DiseaseC-reactive protein measurement

ANKRD44 CBLC ZNF106 RICTOR NDST2

1.67e-031206225EFO_0004458
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

CBLC ZNF106

2.66e-03103222EFO_0008595, EFO_0020944
Diseaseeosinophil measurement

ZNF398 ANKRD44

2.92e-03108222EFO_0803540
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

CBLC ZNF106

3.65e-03121222EFO_0008595, EFO_0020943
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

CBLC ZNF106

4.01e-03127222EFO_0008595, EFO_0020947
DiseaseBladder Neoplasm

KMT2A KMT2D

4.85e-03140222C0005695
DiseaseMalignant neoplasm of urinary bladder

KMT2A KMT2D

4.92e-03141222C0005684
Diseasestomach cancer (is_marker_for)

RICTOR KMT2D

4.99e-03142222DOID:10534 (is_marker_for)
Diseasecholesterol:total lipids ratio, low density lipoprotein cholesterol measurement

CBLC ZNF106

5.12e-03144222EFO_0004611, EFO_0020943
Diseaseneurodegenerative disease (implicated_via_orthology)

SCNN1G RHOT2

5.19e-03145222DOID:1289 (implicated_via_orthology)
Diseasetriglycerides:total lipids ratio, low density lipoprotein cholesterol measurement

CBLC ZNF106

5.55e-03150222EFO_0004611, EFO_0020947
Diseasediabetic nephropathy

ADGRL2 LIMK2

5.55e-03150222EFO_0000401

Protein segments in the cluster

PeptideGeneStartEntry
IIFSHMHAELHALFP

CBLC

126

Q9ULV8
SSLMHSDNPGLELHH

ADGRL2

1306

O95490
SHQSLLLNMSHPLVH

OOSP3

171

A0A2R8YFM6
HMQNAGHPHALSTLD

LIMK2

256

P53671
HSMFPLHLAALNAHS

ANKRD44

371

Q8N8A2
AAAAAAAAAHHLPAM

PRDM12

351

Q9H4Q4
SHSHHLHCLPTLMNM

RICTOR

441

Q6R327
LSPAHEHHSQALMGS

KIR2DL4

341

Q99706
PAMGAHLHLSSHHLE

FAM124B

326

Q9H5Z6
HSNELHPKIHSMASF

GRPR

201

P30550
KGLLPMSHHQHLHSF

KMT2A

3151

Q03164
SCDARNFTLFHHPMH

SCNN1G

266

P51170
LEHHFHSAPCMLAAA

NKX2-3

36

Q8TAU0
CLLQLAMTHPSHHLN

DROSHA

891

Q9NRR4
AGPASLSHMQLHHLD

LGI4

186

Q8N135
ATMAAFPHLVHAELH

RHOT2

571

Q8IXI1
MLLTHQCSHATEHPL

ZNF398

356

Q8TD17
SHMQPHLFHNRSVLA

NDST2

391

P52849
HMLLSFQHSPEAFHL

USP38

336

Q8NB14
DNPTTARHALMSLHH

UAP1

416

Q16222
HSAQLSSDHIIPLMH

ZNF106

936

Q9H2Y7
LLPHQMADFHSATAL

KMT2D

5191

O14686