Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3K36me/H3K36me2 demethylase activity	KDM2B PHF8	3.38e-05	4	48	2	GO:0140680
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1D	5.63e-05	5	48	2	GO:0086007
GeneOntologyMolecularFunction	histone H3K36 demethylase activity	KDM2B PHF8	3.07e-04	11	48	2	GO:0051864
GeneOntologyMolecularFunction	JUN kinase kinase kinase activity	MAP3K9 MAP3K21	3.68e-04	12	48	2	GO:0004706
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1D	5.06e-04	14	48	2	GO:0008331
GeneOntologyMolecularFunction	protein domain specific binding	CACNA1C CACNA1D PAWR RGS6 PPP3R1 FOXA3 CBLB CIT	1.05e-03	875	48	8	GO:0019904
GeneOntologyMolecularFunction	MAP kinase kinase kinase activity	MAP3K9 MAP3K21	1.91e-03	27	48	2	GO:0004709
GeneOntologyMolecularFunction	histone H3 demethylase activity	KDM2B PHF8	2.06e-03	28	48	2	GO:0141052
GeneOntologyMolecularFunction	histone demethylase activity	KDM2B PHF8	2.52e-03	31	48	2	GO:0032452
GeneOntologyMolecularFunction	alpha-actinin binding	CACNA1C CACNA1D	2.52e-03	31	48	2	GO:0051393
GeneOntologyMolecularFunction	protein demethylase activity	KDM2B PHF8	2.68e-03	32	48	2	GO:0140457
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1C CACNA1D PAWR PPP3R1	4.28e-06	48	47	4	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1C CACNA1D PAWR PPP3R1	4.28e-06	48	47	4	GO:1902656
GeneOntologyBiologicalProcess	regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C CACNA1D SESTD1	1.66e-05	22	47	3	GO:1902514
GeneOntologyBiologicalProcess	calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C CACNA1D SESTD1	1.90e-05	23	47	3	GO:0061577
GeneOntologyBiologicalProcess	positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	CACNA1C CACNA1D	5.06e-05	5	47	2	GO:1904879
GeneOntologyBiologicalProcess	calcium ion import	CACNA1C CACNA1D PAWR PPP3R1	7.31e-05	98	47	4	GO:0070509
GeneOntologyBiologicalProcess	neural precursor cell proliferation	ANKRD11 KDM2B OPTN NOTCH2 KIF3A	1.84e-04	233	47	5	GO:0061351
GeneOntologyBiologicalProcess	protein demethylation	KDM2B PHF8	2.26e-04	10	47	2	GO:0006482
GeneOntologyBiologicalProcess	protein dealkylation	KDM2B PHF8	2.26e-04	10	47	2	GO:0008214
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	CACNA1C CACNA1D PAWR PPP3R1	3.05e-04	142	47	4	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	CACNA1C CACNA1D PAWR PPP3R1	3.05e-04	142	47	4	GO:0098659
GeneOntologyCellularComponent	L-type voltage-gated calcium channel complex	CACNA1C CACNA1D	3.08e-04	12	46	2	GO:1990454
GeneOntologyCellularComponent	calcium channel complex	CACNA1C CACNA1D SESTD1	5.57e-04	73	46	3	GO:0034704
GeneOntologyCellularComponent	NuRD complex	CHD4 CHD5	6.31e-04	17	46	2	GO:0016581
GeneOntologyCellularComponent	CHD-type complex	CHD4 CHD5	6.31e-04	17	46	2	GO:0090545
Domain	CHDCT2	CHD4 CHD5	1.70e-05	3	45	2	PF08074
Domain	CHDNT	CHD4 CHD5	1.70e-05	3	45	2	PF08073
Domain	DUF1086	CHD4 CHD5	1.70e-05	3	45	2	IPR009462
Domain	DUF1087	CHD4 CHD5	1.70e-05	3	45	2	IPR009463
Domain	CHD_N	CHD4 CHD5	1.70e-05	3	45	2	IPR012958
Domain	CHD_C2	CHD4 CHD5	1.70e-05	3	45	2	IPR012957
Domain	CAC1F_C	CACNA1C CACNA1D	1.70e-05	3	45	2	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1D	1.70e-05	3	45	2	PF16885
Domain	DUF1087	CHD4 CHD5	1.70e-05	3	45	2	PF06465
Domain	DUF1086	CHD4 CHD5	1.70e-05	3	45	2	PF06461
Domain	DUF1087	CHD4 CHD5	1.70e-05	3	45	2	SM01147
Domain	DUF1086	CHD4 CHD5	1.70e-05	3	45	2	SM01146
Domain	MLK1/MLK2/MLK4	MAP3K9 MAP3K21	3.40e-05	4	45	2	IPR016231
Domain	VDCC_L_a1su	CACNA1C CACNA1D	3.40e-05	4	45	2	IPR005446
Domain	MAP3K10	MAP3K9 MAP3K21	3.40e-05	4	45	2	IPR015785
Domain	Znf_PHD-finger	KDM2B CHD4 PHF8 CHD5	3.87e-05	79	45	4	IPR019787
Domain	PHD	KDM2B CHD4 PHF8 CHD5	6.18e-05	89	45	4	SM00249
Domain	Znf_PHD	KDM2B CHD4 PHF8 CHD5	6.74e-05	91	45	4	IPR001965
Domain	ZF_PHD_2	KDM2B CHD4 PHF8 CHD5	7.98e-05	95	45	4	PS50016
Domain	ZF_PHD_1	KDM2B CHD4 PHF8 CHD5	8.31e-05	96	45	4	PS01359
Domain	VDCC_a1su_IQ	CACNA1C CACNA1D	1.18e-04	7	45	2	IPR014873
Domain	GPHH	CACNA1C CACNA1D	1.18e-04	7	45	2	PF16905
Domain	GPHH_dom	CACNA1C CACNA1D	1.18e-04	7	45	2	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1D	1.18e-04	7	45	2	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1D	1.18e-04	7	45	2	PF08763
Domain	VDCCAlpha1	CACNA1C CACNA1D	2.52e-04	10	45	2	IPR002077
Domain	Znf_FYVE_PHD	KDM2B CHD4 PHF8 CHD5	4.27e-04	147	45	4	IPR011011
Domain	Zinc_finger_PHD-type_CS	CHD4 PHF8 CHD5	5.14e-04	65	45	3	IPR019786
Domain	EF-hand-dom_pair	CACNA1C TPPP3 S100Z PPP3R1 CBLB	6.11e-04	287	45	5	IPR011992
Domain	PHD	CHD4 PHF8 CHD5	7.82e-04	75	45	3	PF00628
Domain	Chromo_domain	CHD4 CHD5	1.51e-03	24	45	2	IPR023780
Domain	JmjC	KDM2B PHF8	1.51e-03	24	45	2	PF02373
Domain	Ser/Thr_kinase_AS	MAP3K9 MAP3K21 CIT GRK7 MKNK2	1.62e-03	357	45	5	IPR008271
Domain	S_TKc	MAP3K9 MAP3K21 CIT GRK7 MKNK2	1.66e-03	359	45	5	SM00220
Domain	PROTEIN_KINASE_ST	MAP3K9 MAP3K21 CIT GRK7 MKNK2	1.72e-03	362	45	5	PS00108
Domain	Chromo	CHD4 CHD5	1.78e-03	26	45	2	PF00385
Domain	CHROMO_1	CHD4 CHD5	2.06e-03	28	45	2	PS00598
Domain	S100/CaBP-9k_CS	S100Z PPP3R1	2.06e-03	28	45	2	IPR001751
Domain	CHROMO_2	CHD4 CHD5	2.06e-03	28	45	2	PS50013
Domain	Protein_kinase_ATP_BS	MAP3K9 MAP3K21 CIT GRK7 MKNK2	2.10e-03	379	45	5	IPR017441
Domain	SNF2_N	CHD4 CHD5	2.69e-03	32	45	2	IPR000330
Domain	JMJC	KDM2B PHF8	2.69e-03	32	45	2	PS51184
Domain	Chromodomain-like	CHD4 CHD5	2.69e-03	32	45	2	IPR016197
Domain	SNF2_N	CHD4 CHD5	2.69e-03	32	45	2	PF00176
Domain	JmjC_dom	KDM2B PHF8	2.69e-03	32	45	2	IPR003347
Domain	JmjC	KDM2B PHF8	2.86e-03	33	45	2	SM00558
Domain	Chromo/shadow_dom	CHD4 CHD5	2.86e-03	33	45	2	IPR000953
Domain	CHROMO	CHD4 CHD5	2.86e-03	33	45	2	SM00298
Domain	RGS	RGS6 GRK7	3.21e-03	35	45	2	PF00615
Domain	RGS	RGS6 GRK7	3.21e-03	35	45	2	SM00315
Domain	DNA/RNA_helicase_DEAH_CS	CHD4 CHD5	3.21e-03	35	45	2	IPR002464
Domain	RGS	RGS6 GRK7	3.39e-03	36	45	2	PS50132
Domain	DEAH_ATP_HELICASE	CHD4 CHD5	3.78e-03	38	45	2	PS00690
Domain	RGS	RGS6 GRK7	3.97e-03	39	45	2	IPR016137
Domain	-	KDM2B CHD4 PHF8 CBLB CHD5	4.35e-03	449	45	5	3.30.40.10
Domain	PROTEIN_KINASE_ATP	MAP3K9 MAP3K21 CIT GRK7 MKNK2	4.77e-03	459	45	5	PS00107
Domain	Znf_RING/FYVE/PHD	KDM2B CHD4 PHF8 CBLB CHD5	4.77e-03	459	45	5	IPR013083
Domain	Prot_kinase_dom	MAP3K9 MAP3K21 CIT GRK7 MKNK2	6.22e-03	489	45	5	IPR000719
Domain	PROTEIN_KINASE_DOM	MAP3K9 MAP3K21 CIT GRK7 MKNK2	6.43e-03	493	45	5	PS50011
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1D	6.98e-05	6	31	2	M47762
Pathway	WP_MAPK_SIGNALING	CACNA1C CACNA1D PPP3R1 MKNK2 SOS2	1.82e-04	246	31	5	M39597
Pathway	KEGG_MAPK_SIGNALING_PATHWAY	CACNA1C CACNA1D PPP3R1 MKNK2 SOS2	2.66e-04	267	31	5	M10792
Pathway	KEGG_MEDICUS_REFERENCE_MLK_JNK_SIGNALING_PATHWAY	MAP3K9 MAP3K21	3.05e-04	12	31	2	M47929
Pathway	WP_INSULIN_SIGNALING	MAP3K9 CBLB KIF3A SOS2	3.96e-04	160	31	4	M39482
Pathway	WP_INSULIN_SIGNALING	MAP3K9 CBLB KIF3A SOS2	3.96e-04	160	31	4	MM15956
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_VGCC_CA2_APOPTOTIC_PATHWAY_N01004	CACNA1C CACNA1D	4.19e-04	14	31	2	M47692
Pathway	KEGG_ALZHEIMERS_DISEASE	CACNA1C CACNA1D PPP3R1 NDUFB7	4.55e-04	166	31	4	M16024
Pathway	WP_ALZHEIMERS_DISEASE	CACNA1C CACNA1D PPP3R1	5.62e-04	74	31	3	MM15962
Pubmed	Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons.	CACNA1C CACNA1D	1.87e-06	2	48	2	24849370
Pubmed	Deletion of the L-type calcium channel Ca(V) 1.3 but not Ca(V) 1.2 results in a diminished sAHP in mouse CA1 pyramidal neurons.	CACNA1C CACNA1D	1.87e-06	2	48	2	20014384
Pubmed	Differential zinc permeation and blockade of L-type Ca2+ channel isoforms Cav1.2 and Cav1.3.	CACNA1C CACNA1D	1.87e-06	2	48	2	26049024
Pubmed	Divide and conquer: an L-type voltage-gated calcium channel subtype finds a role in conditioned fear.	CACNA1C CACNA1D	1.87e-06	2	48	2	17015854
Pubmed	Role of putative voltage-sensor countercharge D4 in regulating gating properties of CaV1.2 and CaV1.3 calcium channels.	CACNA1C CACNA1D	1.87e-06	2	48	2	30001160
Pubmed	Genetic polymorphisms of L-type calcium channel alpha1C and alpha1D subunit genes are associated with sensitivity to the antihypertensive effects of L-type dihydropyridine calcium-channel blockers.	CACNA1C CACNA1D	1.87e-06	2	48	2	19225208
Pubmed	Ca1.2 and CaV1.3 neuronal L-type calcium channels: differential targeting and signaling to pCREB.	CACNA1C CACNA1D	1.87e-06	2	48	2	16706838
Pubmed	Temperature-sensitive Cav1.2 calcium channels support intrinsic firing of pyramidal neurons and provide a target for the treatment of febrile seizures.	CACNA1C CACNA1D	1.87e-06	2	48	2	23761887
Pubmed	Non-voltage-gated L-type Ca2+ channels in human T cells: pharmacology and molecular characterization of the major alpha pore-forming and auxiliary beta-subunits.	CACNA1C CACNA1D	1.87e-06	2	48	2	14981074
Pubmed	Rescue and worsening of congenital heart block-associated electrocardiographic abnormalities in two transgenic mice.	CACNA1C CACNA1D	1.87e-06	2	48	2	21352396
Pubmed	CaV1.2 and CaV1.3 channel hyperactivation in mouse islet β cells exposed to type 1 diabetic serum.	CACNA1C CACNA1D	1.87e-06	2	48	2	25292336
Pubmed	Ca(v)1.3 channels produce persistent calcium sparklets, but Ca(v)1.2 channels are responsible for sparklets in mouse arterial smooth muscle.	CACNA1C CACNA1D	1.87e-06	2	48	2	17526649
Pubmed	Ligand-activated signal transduction in the 2-cell embryo.	CACNA1C CACNA1D	1.87e-06	2	48	2	12606379
Pubmed	Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators.	CACNA1C CACNA1D	1.87e-06	2	48	2	24941892
Pubmed	Different roles attributed to Cav1 channel subtypes in spontaneous action potential firing and fine tuning of exocytosis in mouse chromaffin cells.	CACNA1C CACNA1D	1.87e-06	2	48	2	21054386
Pubmed	Molecular nature of anomalous L-type calcium channels in mouse cerebellar granule cells.	CACNA1C CACNA1D	1.87e-06	2	48	2	17409250
Pubmed	Neuronal L-type calcium channels open quickly and are inhibited slowly.	CACNA1C CACNA1D	1.87e-06	2	48	2	16267232
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area.	CACNA1C CACNA1D	1.87e-06	2	48	2	24848473
Pubmed	Equal sensitivity of Cav1.2 and Cav1.3 channels to the opposing modulations of PKA and PKG in mouse chromaffin cells.	CACNA1C CACNA1D	1.87e-06	2	48	2	22826131
Pubmed	The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function.	CACNA1C CACNA1D	1.87e-06	2	48	2	24996399
Pubmed	Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization.	CACNA1C CACNA1D	1.87e-06	2	48	2	24470632
Pubmed	Cav1.2 and Cav1.3 L-type calcium channels operate in a similar voltage range but show different coupling to Ca(2+)-dependent conductances in hippocampal neurons.	CACNA1C CACNA1D	1.87e-06	2	48	2	24760982
Pubmed	An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.	CACNA1C CACNA1D	1.87e-06	2	48	2	24086669
Pubmed	The intracellular II-III loops of Cav1.2 and Cav1.3 uncouple L-type voltage-gated Ca2+ channels from glucagon-like peptide-1 potentiation of insulin secretion in INS-1 cells via displacement from lipid rafts.	CACNA1C CACNA1D	5.59e-06	3	48	2	19351867
Pubmed	Truncation of murine CaV1.2 at Asp-1904 results in heart failure after birth.	CACNA1C CACNA1D	5.59e-06	3	48	2	21832054
Pubmed	Angiotensin II suppresses long-term depression in the lateral amygdala of mice via L-type calcium channels.	CACNA1C CACNA1D	5.59e-06	3	48	2	17289261
Pubmed	Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.	CACNA1C CACNA1D	5.59e-06	3	48	2	23973784
Pubmed	G protein-gated IKACh channels as therapeutic targets for treatment of sick sinus syndrome and heart block.	CACNA1C CACNA1D	5.59e-06	3	48	2	26831068
Pubmed	Impairment of hippocampal gamma-frequency oscillations in vitro in mice overexpressing human amyloid precursor protein (APP).	CACNA1C CACNA1D	5.59e-06	3	48	2	17767505
Pubmed	MicroRNA-1976 regulates degeneration of the sinoatrial node by targeting Cav1.2 and Cav1.3 ion channels.	CACNA1C CACNA1D	5.59e-06	3	48	2	31302118
Pubmed	Distinct localization and modulation of Cav1.2 and Cav1.3 L-type Ca2+ channels in mouse sinoatrial node.	CACNA1C CACNA1D	5.59e-06	3	48	2	23045342
Pubmed	Truncation of murine CaV1.2 at Asp 1904 increases CaV1.3 expression in embryonic atrial cardiomyocytes.	CACNA1C CACNA1D	5.59e-06	3	48	2	23338940
Pubmed	Molecular diversity of L-type calcium channels. Evidence for alternative splicing of the transcripts of three non-allelic genes.	CACNA1C CACNA1D	5.59e-06	3	48	2	2173707
Pubmed	Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons.	CACNA1C CACNA1D	5.59e-06	3	48	2	24934288
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	USP36 ANKRD11 KDM2B CHD4 DNAJC1 RPL7L1 PHF8 UBN1 GTF3C1 ATAD5	8.84e-06	1294	48	10	30804502
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1D	1.12e-05	4	48	2	20937870
Pubmed	Molecular coupling of a Ca2+-activated K+ channel to L-type Ca2+ channels via alpha-actinin2.	CACNA1C CACNA1D	1.12e-05	4	48	2	17110593
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	CACNA1C CACNA1D	1.86e-05	5	48	2	31663850
Pubmed	Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels.	CACNA1C CACNA1D	1.86e-05	5	48	2	11296258
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1C CACNA1D	1.86e-05	5	48	2	15451373
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	KDM2B CHD4 PHF8 UBN1 GTF3C1 ATAD5 CHD5	1.91e-05	608	48	7	36089195
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ANKRD11 MAP3K9 OPTN MAP3K21 HECTD1 GRK7 NOTCH2 ASS1	2.14e-05	861	48	8	36931259
Pubmed	Voltage-gated calcium channels in developing GnRH-1 neuronal system in the mouse.	CACNA1C CACNA1D	2.79e-05	6	48	2	16029198
Pubmed	Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.	CACNA1C CACNA1D	2.79e-05	6	48	2	21224388
Pubmed	L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.	CACNA1C CACNA1D	2.79e-05	6	48	2	23734214
Pubmed	CIB1 is a regulator of pathological cardiac hypertrophy.	CACNA1C PPP3R1	2.79e-05	6	48	2	20639889
Pubmed	NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function.	CHD4 PHF8 NOTCH2 KIF3A	3.10e-05	129	48	4	23022380
Pubmed	Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.	CACNA1C PHF8	3.90e-05	7	48	2	21057379
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1D	3.90e-05	7	48	2	12900400
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SESTD1 CHD4 PPP3R1 HECTD1 CIT NDUFB7 PRRC2A KIF3A SOS2	5.70e-05	1285	48	9	35914814
Pubmed	Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation.	KDM2B CHD4	6.67e-05	9	48	2	21245044
Pubmed	The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.	CHD4 ATAD5 CHD5	6.85e-05	57	48	3	21555454
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	CHD4 RPL7L1 PHF8 GTF3C1 HECTD1 ATAD5 PRRC2A	7.75e-05	759	48	7	35915203
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KDM2B CHD4 PHF8 UBN1 GTF3C1 PRRC2A NOTCH2	8.76e-05	774	48	7	15302935
Pubmed	The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4.	ANKRD11 CHD4 UBN1 PRRC2A ZBED6	9.41e-05	332	48	5	37433992
Pubmed	NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth.	CACNA1C CACNA1D	1.02e-04	11	48	2	18809727
Pubmed	MYC Protein Interactome Profiling Reveals Functionally Distinct Regions that Cooperate to Drive Tumorigenesis.	KDM2B CHD4 RPL7L1 CLSPN GTF3C1	1.04e-04	339	48	5	30415952
Pubmed	Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.	HECTD1 PRRC2A BAG1	1.06e-04	66	48	3	24811749
Pubmed	Bioinformatics and cellular signaling.	SESTD1 CBLB MKNK2 SOS2	1.18e-04	182	48	4	15102471
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	ANKRD11 MGAT4B UBN1 HECTD1 CIT BTBD7 NOTCH2 CHD5	1.24e-04	1105	48	8	35748872
Pubmed	Human transcription factor protein interaction networks.	KDM2B RPL7L1 PHF8 UBN1 GTF3C1 CIT ATAD5 PRRC2A CHD5	1.28e-04	1429	48	9	35140242
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP36 CHD4 PHF8 CLSPN ATAD5 NOTCH2 CHD5 ASS1	1.32e-04	1116	48	8	31753913
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	USP36 ANKRD11 KDM2B DNAJC1 RPL7L1 CIT ATAD5 PRRC2A ZBED6	1.82e-04	1497	48	9	31527615
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1D	1.94e-04	15	48	2	20188150
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD4 CHD5	1.94e-04	15	48	2	35695185
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1D	1.94e-04	15	48	2	24453333
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	CHD4 CHD5	1.94e-04	15	48	2	25247294
Pubmed	Modifier genes and protective alleles in humans and mice.	TUB NOTCH2	2.21e-04	16	48	2	12787792
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MAP3K9 CHD4 OPTN CLSPN GTF3C1 MAP3K21 CBLB	2.37e-04	910	48	7	36736316
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1C CACNA1D	2.50e-04	17	48	2	27725084
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD4 CHD5	2.50e-04	17	48	2	27806305
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	KDM2B PAWR CHD4 HECTD1 CIT PRRC2A KIF3A ASS1	2.81e-04	1247	48	8	27684187
Pubmed	Epidermal growth factor receptor phosphorylation sites Ser991 and Tyr998 are implicated in the regulation of receptor endocytosis and phosphorylations at Ser1039 and Thr1041.	CBLB SOS2	2.81e-04	18	48	2	19531499
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	CBLB SOS2	3.14e-04	19	48	2	31959764
Pubmed	A role for the primary cilium in Notch signaling and epidermal differentiation during skin development.	NOTCH2 KIF3A	3.85e-04	21	48	2	21703454
Pubmed	The ubiquitin-specific protease USP36 SUMOylates EXOSC10 and promotes the nucleolar RNA exosome function in rRNA processing.	USP36 CHD4 RPL7L1 GTF3C1 PRRC2A	5.30e-04	483	48	5	36912080
Pubmed	A human MAP kinase interactome.	MAP3K21 CBLB KIF3A MKNK2 SOS2	5.45e-04	486	48	5	20936779
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ANKRD11 CACNA1C GTF3C1 NSUN7 ASS1	6.03e-04	497	48	5	36774506
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	MAP3K9 SESTD1 CIT PPFIA2	6.14e-04	281	48	4	28706196
Pubmed	Excess neuropeptides in lung signal through endothelial cells to impair gas exchange.	FOXA3 NOTCH2	6.40e-04	27	48	2	35303432
Pubmed	Notch signaling prevents mucous metaplasia in mouse conducting airways during postnatal development.	FOXA3 NOTCH2	6.40e-04	27	48	2	21791528
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	PAWR CHD4 OPTN DNAJC1 RPL7L1 UBN1 GTF3C1 PRRC2A	7.30e-04	1440	48	8	30833792
Pubmed	Oncogenic RAS directs silencing of tumor suppressor genes through ordered recruitment of transcriptional repressors.	MAP3K9 S100Z	7.39e-04	29	48	2	24105743
Pubmed	Murine chromosomal location of eight members of the hepatocyte nuclear factor 3/fork head winged helix family of transcription factors.	FOXA3 SOS2	7.39e-04	29	48	2	7789972
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	PAWR PHF8 UBN1 GTF3C1 NOTCH2	8.25e-04	533	48	5	25544563
Pubmed	Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.	CHD4 RPL7L1 PHF8 GTF3C1 ATAD5	8.25e-04	533	48	5	30554943
Pubmed	Placing the HIRA histone chaperone complex in the chromatin landscape.	UBN1 GTF3C1	8.45e-04	31	48	2	23602572
Pubmed	Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays.	OPTN CBLB	9.01e-04	32	48	2	19285159
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ANKRD11 CACNA1C GTF3C1 HECTD1 PPFIA2 NOTCH2 ASS1 SOS2	9.07e-04	1489	48	8	28611215
Pubmed	The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins.	PAWR CHD4 GTF3C1 HECTD1 PRRC2A	9.26e-04	547	48	5	37267103
Pubmed	Analysis of mouse embryonic patterning and morphogenesis by forward genetics.	HECTD1 KIF3A	9.58e-04	33	48	2	15755804
Pubmed	The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.	CACNA1D CHD5	9.58e-04	33	48	2	22357600
Pubmed	Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.	KDM2B PHF8	9.58e-04	33	48	2	26864203
Pubmed	Tandem immunoprecipitation of phosphotyrosine-mass spectrometry (TIPY-MS) indicates C19ORF19 becomes tyrosine-phosphorylated and associated with activated epidermal growth factor receptor.	CBLB SOS2	9.58e-04	33	48	2	18271526
Pubmed	Defining the membrane proteome of NK cells.	CHD4 DNAJC1 GTF3C1 CIT PRRC2A NOTCH2 CHD5	1.05e-03	1168	48	7	19946888
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD4 CHD5	1.08e-03	35	48	2	27142060
Pubmed	The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.	CHD4 PRRC2A CHD5	1.11e-03	147	48	3	28977470
Pubmed	A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.	CHD4 CHD5	1.14e-03	36	48	2	29089422
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	CACNA1C CACNA1D	1.27e-03	38	48	2	30786075
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD4 CHD5	1.27e-03	38	48	2	33283408
Interaction	NOP56 interactions	USP36 ANKRD11 CHD4 OPTN PHF8 HECTD1 ARHGAP36 CIT ATAD5 PRRC2A	7.52e-07	570	48	10	int:NOP56
Interaction	POLR1G interactions	USP36 ANKRD11 KDM2B PHF8 CLSPN GTF3C1 HECTD1 CIT ATAD5	1.96e-06	489	48	9	int:POLR1G
Interaction	ADAR interactions	USP36 SESTD1 CHD4 FOXA3 HECTD1 CIT CHD5	4.82e-06	286	48	7	int:ADAR
Interaction	NIFK interactions	USP36 ANKRD11 CHD4 RPL7L1 PHF8 HECTD1 CIT ATAD5	7.31e-06	431	48	8	int:NIFK
Interaction	RPL4 interactions	USP36 ANKRD11 CHD4 DNAJC1 RPL7L1 GTF3C1 HECTD1 CIT PRRC2A BAG1	1.02e-05	764	48	10	int:RPL4
Interaction	H2BC12 interactions	USP36 ANKRD11 CHD4 CIT PRRC2A CHD5 BAG1	1.05e-05	322	48	7	int:H2BC12
Interaction	KPNA2 interactions	USP36 CHD4 HECTD1 ARHGAP36 CIT BAG1 ASS1 SOS2	2.79e-05	519	48	8	int:KPNA2
Interaction	PUM3 interactions	USP36 CHD4 RPL7L1 HECTD1 CIT PRRC2A	2.98e-05	254	48	6	int:PUM3
Interaction	WDR12 interactions	USP36 OPTN RPL7L1 HECTD1 CIT	4.09e-05	162	48	5	int:WDR12
Interaction	COIL interactions	USP36 ANKRD11 KDM2B CHD4 PHF8 GTF3C1 HECTD1 CIT	4.33e-05	552	48	8	int:COIL
Interaction	RPL12 interactions	USP36 CHD4 OPTN DNAJC1 HECTD1 CIT BAG1	4.34e-05	402	48	7	int:RPL12
Interaction	GTF3C2 interactions	USP36 GTF3C1 HECTD1 CIT BAG1	5.00e-05	169	48	5	int:GTF3C2
Interaction	EIF4A2 interactions	OPTN HECTD1 CIT PRRC2A BAG1	5.29e-05	171	48	5	int:EIF4A2
Interaction	RBM15 interactions	CHD4 HECTD1 ARHGAP36 CIT SOS2	5.90e-05	175	48	5	int:RBM15
Interaction	RPL27 interactions	USP36 CHD4 OPTN DNAJC1 HECTD1 CIT BAG1	6.73e-05	431	48	7	int:RPL27
Interaction	EXOSC2 interactions	USP36 PAWR HECTD1 CIT PRRC2A	6.74e-05	180	48	5	int:EXOSC2
Interaction	DNAJC9 interactions	USP36 RPL7L1 GTF3C1 HECTD1 CIT KIF3A	6.97e-05	296	48	6	int:DNAJC9
Interaction	ZNF330 interactions	USP36 ANKRD11 KDM2B PHF8 GTF3C1 NDUFB7 ATAD5	8.34e-05	446	48	7	int:ZNF330
Interaction	BOP1 interactions	USP36 CHD4 RPL7L1 HECTD1 CIT	8.93e-05	191	48	5	int:BOP1
Interaction	EXOSC3 interactions	USP36 OPTN HECTD1 CIT	9.39e-05	100	48	4	int:EXOSC3
Interaction	NCL interactions	USP36 CHD4 OPTN DNAJC1 GTF3C1 HECTD1 CIT BTBD7 BAG1	9.57e-05	798	48	9	int:NCL
Interaction	RRP1B interactions	USP36 CHD4 DNAJC1 RPL7L1 HECTD1 CIT	9.65e-05	314	48	6	int:RRP1B
Interaction	ABCF1 interactions	USP36 PAWR CHD4 HECTD1 CIT	1.13e-04	201	48	5	int:ABCF1
Interaction	FAM228B interactions	FAM228B CIT	1.16e-04	7	48	2	int:FAM228B
Interaction	NOLC1 interactions	USP36 CHD4 GTF3C1 HECTD1 CIT MKNK2	1.17e-04	325	48	6	int:NOLC1
Interaction	RPL19 interactions	USP36 CHD4 OPTN RPL7L1 HECTD1 CIT PRRC2A BAG1	1.19e-04	638	48	8	int:RPL19
Interaction	BAZ1B interactions	CHD4 RPL7L1 HECTD1 CIT ATAD5	1.22e-04	204	48	5	int:BAZ1B
Interaction	RPL30 interactions	USP36 CHD4 DNAJC1 RPL7L1 HECTD1 CIT BAG1	1.22e-04	474	48	7	int:RPL30
Interaction	WDR36 interactions	USP36 CHD4 UBN1 HECTD1 CIT	1.33e-04	208	48	5	int:WDR36
Interaction	MACROH2A2 interactions	USP36 CHD4 RPL7L1 HECTD1 CIT	1.42e-04	211	48	5	int:MACROH2A2
Interaction	RPS2 interactions	USP36 CHD4 RPL7L1 GTF3C1 HECTD1 CIT NOTCH2 BAG1	1.46e-04	657	48	8	int:RPS2
Interaction	SSH2 interactions	HECTD1 CIT KIF3A	1.46e-04	43	48	3	int:SSH2
Interaction	PDHB interactions	PPP3R1 HECTD1 CIT NDUFB7 BAG1 ASS1	1.54e-04	342	48	6	int:PDHB
Interaction	POLR1E interactions	USP36 KDM2B PHF8 GTF3C1 HECTD1 ATAD5	1.74e-04	350	48	6	int:POLR1E
Interaction	HMGN2 interactions	OPTN MXRA5 PHF8 CIT PRRC2A	1.81e-04	222	48	5	int:HMGN2
Interaction	RPL7A interactions	USP36 CHD4 DNAJC1 RPL7L1 HECTD1 CIT MKNK2 BAG1	1.82e-04	679	48	8	int:RPL7A
Interaction	RPL31 interactions	USP36 ANKRD11 CHD4 RPL7L1 PHF8 HECTD1 CIT ATAD5	1.84e-04	680	48	8	int:RPL31
Interaction	RIF1 interactions	USP36 PHF8 UBN1 HECTD1 CIT	1.92e-04	225	48	5	int:RIF1
Interaction	RPL21 interactions	USP36 CHD4 DNAJC1 HECTD1 CIT BAG1	1.94e-04	357	48	6	int:RPL21
Interaction	LOC102724159 interactions	USP36 CHD4	1.98e-04	9	48	2	int:LOC102724159
Interaction	XRCC5 interactions	USP36 KDM2B CHD4 OPTN HECTD1 CIT BAG1	2.03e-04	515	48	7	int:XRCC5
Interaction	TXN interactions	ANKRD11 PAWR CHD4 CIT BAG1 ASS1	2.03e-04	360	48	6	int:TXN
Interaction	EIF6 interactions	USP36 CHD4 PHF8 HECTD1 CIT SOS2	2.19e-04	365	48	6	int:EIF6
Interaction	GANAB interactions	CHD4 DNAJC1 ARHGAP36 CIT PRRC2A BAG1	2.29e-04	368	48	6	int:GANAB
Interaction	PNO1 interactions	USP36 CHD4 HECTD1 CIT	2.51e-04	129	48	4	int:PNO1
Interaction	RPS27A interactions	USP36 CHD4 OPTN ARHGAP36 CIT NOTCH2 BAG1	2.59e-04	536	48	7	int:RPS27A
Interaction	CENPA interactions	USP36 ANKRD11 KDM2B PHF8 GTF3C1 ATAD5	2.60e-04	377	48	6	int:CENPA
Interaction	RPL8 interactions	USP36 CHD4 DNAJC1 RPL7L1 HECTD1 CIT BAG1	2.68e-04	539	48	7	int:RPL8
Interaction	RPL23 interactions	USP36 CHD4 HECTD1 CIT NOTCH2 BAG1 ASS1	2.71e-04	540	48	7	int:RPL23
Interaction	HNRNPM interactions	USP36 CHD4 DNAJC1 GTF3C1 HECTD1 CIT PRRC2A BAG1	2.79e-04	723	48	8	int:HNRNPM
Interaction	NOC3L interactions	USP36 CHD4 RPL7L1 HECTD1 CIT	2.80e-04	244	48	5	int:NOC3L
Interaction	PHGDH interactions	USP36 GTF3C1 HECTD1 CIT BAG1 ASS1	2.91e-04	385	48	6	int:PHGDH
Interaction	CYCS interactions	USP36 OPTN NDUFB7 PRRC2A BAG1	2.96e-04	247	48	5	int:CYCS
Interaction	RPL9 interactions	USP36 CHD4 DNAJC1 HECTD1 CIT BAG1	3.48e-04	398	48	6	int:RPL9
Interaction	H3-3A interactions	KDM2B PAWR CHD4 PHF8 UBN1 GTF3C1 ATAD5 CHD5	3.54e-04	749	48	8	int:H3-3A
Interaction	DDX50 interactions	USP36 CHD4 HECTD1 ARHGAP36 CIT	3.55e-04	257	48	5	int:DDX50
Interaction	NOL9 interactions	USP36 CHD4 HECTD1 CIT	3.61e-04	142	48	4	int:NOL9
Interaction	DNTTIP2 interactions	USP36 PHF8 HECTD1 CIT	3.81e-04	144	48	4	int:DNTTIP2
Interaction	RBBP4 interactions	USP36 KDM2B CHD4 HECTD1 CIT CHD5 BAG1	3.88e-04	573	48	7	int:RBBP4
Interaction	MIF interactions	CHD4 OPTN CLSPN MKNK2 BAG1	4.01e-04	264	48	5	int:MIF
Interaction	CD55 interactions	CIT NDUFB7 NOTCH2	4.35e-04	62	48	3	int:CD55
Interaction	UTP18 interactions	USP36 CHD4 HECTD1 CIT	4.68e-04	152	48	4	int:UTP18
Interaction	RPL5 interactions	USP36 CHD4 DNAJC1 HECTD1 CIT PRRC2A BAG1	5.42e-04	606	48	7	int:RPL5
Interaction	NOC2L interactions	USP36 CHD4 RPL7L1 HECTD1 CIT	5.42e-04	282	48	5	int:NOC2L
Interaction	WDR3 interactions	USP36 CHD4 HECTD1 CIT	5.67e-04	160	48	4	int:WDR3
Interaction	SNU13 interactions	USP36 CHD4 GTF3C1 HECTD1 CIT	5.69e-04	285	48	5	int:SNU13
Interaction	CABP1 interactions	CACNA1C PPP3R1	5.72e-04	15	48	2	int:CABP1
Interaction	SCN11A interactions	CACNA1C CACNA1D	5.72e-04	15	48	2	int:SCN11A
Interaction	NOL10 interactions	USP36 CHD4 HECTD1 CIT	5.94e-04	162	48	4	int:NOL10
Interaction	MAK16 interactions	USP36 HECTD1 CIT TUB	5.94e-04	162	48	4	int:MAK16
Interaction	EXOSC9 interactions	USP36 MAP3K21 HECTD1 CIT	5.94e-04	162	48	4	int:EXOSC9
Interaction	RBM34 interactions	USP36 CHD4 RPL7L1 HECTD1 TUB	6.15e-04	290	48	5	int:RBM34
Interaction	PRRC2C interactions	USP36 CHD4 HECTD1 CIT PRRC2A	6.15e-04	290	48	5	int:PRRC2C
Interaction	RPN1 interactions	USP36 CHD4 DNAJC1 PHF8 HECTD1 ARHGAP36 CIT NOTCH2	6.16e-04	814	48	8	int:RPN1
Interaction	JAK2 interactions	OPTN CLSPN TUB ASS1	6.37e-04	165	48	4	int:JAK2
Interaction	NOL7 interactions	USP36 HECTD1 CIT	6.47e-04	71	48	3	int:NOL7
Interaction	PIH1D2 interactions	ANKRD11 TBATA CIT	6.47e-04	71	48	3	int:PIH1D2
Interaction	DDX41 interactions	USP36 CHD4 HECTD1 CIT	6.51e-04	166	48	4	int:DDX41
Interaction	SPMIP5 interactions	ANKRD11 KIF3A	6.53e-04	16	48	2	int:SPMIP5
Interaction	UBAP2L interactions	USP36 OPTN HECTD1 CIT PRRC2A	6.96e-04	298	48	5	int:UBAP2L
Interaction	IMMT interactions	USP36 ANKRD11 SESTD1 OPTN CIT PRRC2A	6.96e-04	454	48	6	int:IMMT
Interaction	NRIP1 interactions	SESTD1 HECTD1 CIT KIF3A	7.12e-04	170	48	4	int:NRIP1
Interaction	UTP4 interactions	USP36 ANKRD11 CLSPN CIT	7.12e-04	170	48	4	int:UTP4
Interaction	BRIX1 interactions	USP36 CHD4 OPTN HECTD1 CIT	7.17e-04	300	48	5	int:BRIX1
Interaction	MACROH2A1 interactions	USP36 CHD4 PHF8 GTF3C1 HECTD1 CIT	7.29e-04	458	48	6	int:MACROH2A1
Interaction	ATP5F1C interactions	USP36 PAWR CHD4 HECTD1 CIT NDUFB7	7.37e-04	459	48	6	int:ATP5F1C
Interaction	PWP2 interactions	USP36 CHD4 HECTD1 CIT	7.44e-04	172	48	4	int:PWP2
Interaction	MTA3 interactions	CHD4 CIT NOTCH2 CHD5	7.60e-04	173	48	4	int:MTA3
Interaction	DDX56 interactions	USP36 CHD4 RPL7L1 HECTD1 CIT	7.61e-04	304	48	5	int:DDX56
Interaction	MYBBP1A interactions	USP36 CHD4 DNAJC1 RPL7L1 HECTD1 CIT	7.71e-04	463	48	6	int:MYBBP1A
Interaction	CBX3 interactions	KDM2B CHD4 CLSPN GTF3C1 CIT ATAD5 CHD5	7.90e-04	646	48	7	int:CBX3
Interaction	NUP133 interactions	CACNA1C DNAJC1 HECTD1 CIT	7.94e-04	175	48	4	int:NUP133
Interaction	MKI67 interactions	USP36 CHD4 OPTN GTF3C1 HECTD1 CIT GRK7	8.05e-04	648	48	7	int:MKI67
Interaction	RPS8 interactions	USP36 CHD4 RPL7L1 HECTD1 CIT PRRC2A BAG1	8.12e-04	649	48	7	int:RPS8
Interaction	NOP58 interactions	USP36 CHD4 HECTD1 ARHGAP36 CIT	8.19e-04	309	48	5	int:NOP58
Interaction	PANK4 interactions	FOXA3 CIT BAG1	8.20e-04	77	48	3	int:PANK4
Interaction	TBL3 interactions	USP36 CHD4 HECTD1 CIT	8.45e-04	178	48	4	int:TBL3
Interaction	S100B interactions	KDM2B PHF8 S100Z ATAD5	8.63e-04	179	48	4	int:S100B
Interaction	H1-4 interactions	USP36 CHD4 RPL7L1 PHF8 HECTD1 CIT BAG1	8.65e-04	656	48	7	int:H1-4
Interaction	HADHB interactions	USP36 DNAJC1 RPL7L1 PHF8 ARHGAP36 CIT	8.91e-04	476	48	6	int:HADHB
GeneFamily	PHD finger proteins	KDM2B CHD4 PHF8 CHD5	3.34e-05	90	37	4	88
GeneFamily	PHD finger proteins\|NuRD complex	CHD4 CHD5	2.66e-04	12	37	2	1305
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K9 MAP3K21	1.09e-03	24	37	2	654
GeneFamily	PHD finger proteins\|Lysine demethylases	KDM2B PHF8	1.09e-03	24	37	2	485
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1D	1.28e-03	26	37	2	253
GeneFamily	Ankyrin repeat domain containing	ANKRD11 HECTD1 NOTCH2	1.32e-02	242	37	3	403
Coexpression	GARY_CD5_TARGETS_UP	ANKRD11 SESTD1 MGAT4B PRRC2A BTBD7 KIF3A MKNK2	2.32e-05	473	48	7	M17693
Coexpression	GSE6259_BCELL_VS_CD4_TCELL_UP	CHD4 UBN1 PRRC2A ZBED6 MKNK2	2.65e-05	192	48	5	M6732
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	ANKRD11 KDM2B PAWR CBLB MKNK2	2.14e-06	195	48	5	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C CACNA1D PPFIA2 CHD5 KIF3A	2.30e-06	198	48	5	0ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1C PAWR RGS6 PPFIA2	2.65e-05	160	48	4	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C RGS6 PPFIA2 CHD5	2.85e-05	163	48	4	51dee6c21cbeca4e17d1cc386e203f0c403089e8
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SESTD1 PAWR CHD4 MKNK2	2.85e-05	163	48	4	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C RGS6 PPFIA2 NOTCH2	3.36e-05	170	48	4	5570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	MAP3K9 CLSPN CIT ATAD5	3.44e-05	171	48	4	4ede6e916e593f208f2f8ccf82ef2335e061fc86
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	SESTD1 PAWR CHD4 MKNK2	3.60e-05	173	48	4	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	PND14-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MAP3K9 RPL7L1 CLSPN ATAD5	3.68e-05	174	48	4	09b091e24317c3f7bac043f04762a533e30793de
ToppCell	367C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CLSPN CIT ATAD5 NSUN7	3.76e-05	175	48	4	0b1aaa028ba844d4bcb4509fdab8bee648373935
ToppCell	COVID-19-Heart-VSMC\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA1C PAWR RGS6 PPFIA2	4.11e-05	179	48	4	a69ad6912b5c10bb9f9d800f724c792341e9bab1
ToppCell	RA-13._Vascular_Smooth_Muscle\|RA / Chamber and Cluster_Paper	CACNA1C PAWR RGS6 PPFIA2	4.48e-05	183	48	4	818fd886e0188091310825f9145fa53328f2c979
ToppCell	RA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1C PAWR RGS6 PPFIA2	4.48e-05	183	48	4	cae2ee08f985a6f005b4b8e959e465350315156a
ToppCell	PCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating1_(8)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MAP3K9 PAWR TPPP3 MAP3K21	4.87e-05	187	48	4	c2940aec30b3c2c113f6a65126dc6f1969cf301e
ToppCell	PCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating2_(13)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MAP3K9 MAP3K21 CIT NSUN7	5.40e-05	192	48	4	25378b5e4b0cea8415ff125783511fc25a56fc00
ToppCell	PCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	MAP3K9 PAWR TPPP3 MAP3K21	5.51e-05	193	48	4	ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCell	droplet-Limb_Muscle-MUSCLE\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD11 UBN1 HECTD1 ZBED6	5.62e-05	194	48	4	e3d63874111d1e8da3977329426e4dcf68d6de87
ToppCell	PCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	MAP3K9 PAWR TPPP3 MAP3K21	5.62e-05	194	48	4	c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCell	COVID-19-lung-Proliferative_fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	CACNA1C CLSPN CIT ATAD5	5.85e-05	196	48	4	2ce8a787f2731faa913d20342d73041d59468f27
ToppCell	PCW_10-12-Epithelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MAP3K9 PAWR TPPP3 MAP3K21	5.85e-05	196	48	4	9bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCell	PBMC-Control-cDC_3\|Control / Compartment, Disease Groups and Clusters	NBPF10 KDM2B ZBED6 NOTCH2	5.85e-05	196	48	4	09d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	MAP3K9 PAWR TPPP3 MAP3K21	5.97e-05	197	48	4	22b26bac3a99b20c73bfa6e6f81026d064eaa9e8
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C CACNA1D PPFIA2 CHD5	6.08e-05	198	48	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	(220)_CD8+_Cytotoxic_T_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	OPTN DNAJC1 GTF3C1 CBLB	6.08e-05	198	48	4	2af389b8ea5767ba56fe64d719afe5be3f9a43ec
ToppCell	(2)_NK/T-(22)_CD8+_T_cell-(220)_CD8+_Cytotoxic_T_cell\|(22)_CD8+_T_cell / immune cells in Peripheral Blood (logTPM normalization)	OPTN DNAJC1 GTF3C1 NDUFB7	6.08e-05	198	48	4	1bb60688ff0e42471c8b646652fe95b9b28c41a3
ToppCell	(04)_Interm._basal>secr.\|World / shred by cell type by condition	NOTCH2 MKNK2 BAG1 ASS1	6.20e-05	199	48	4	ed399244433f781fc291a9bff16825b8a3ca294f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal\|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.	OPTN PPFIA2 CHD5 KIF3A	6.20e-05	199	48	4	5de2a32bc2e9c752eb19a013b1807949153728fc
ToppCell	Frontal_cortex-Neuronal\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	MAP3K9 PPP3R1 CHD5 KIF3A	6.20e-05	199	48	4	f88039d862f3bfa01dc39d2de4f3f548dc5a0e61
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-dn_T\|ICU-NoSEP / Disease, condition lineage and cell class	OPTN DNAJC1 GTF3C1 CBLB	6.20e-05	199	48	4	7fb211f803a8b3a2cfa9455386abea08131c6b52
ToppCell	severe-CD8+_Tem\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	OPTN DNAJC1 GTF3C1 CBLB	6.33e-05	200	48	4	6aa77955017d073a96324e4db6b9950a2ec46cf8
ToppCell	severe-CD8+_Tem\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	OPTN DNAJC1 GTF3C1 CBLB	6.33e-05	200	48	4	aaa2cd326dc15dee2fd975ca133359c5826f6a75
ToppCell	droplet-Skin-nan-18m-Epithelial-basal_cell_of_epidermis\|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBATA NSUN7 ASS1	2.39e-04	112	48	3	32c6ab8e9b71c6c3df7e3e119b88e6ad1b895d50
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CLSPN MAP3K21 ASS1	4.80e-04	142	48	3	e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCell	10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor\|bone_marrow / Manually curated celltypes from each tissue	CACNA1D CLSPN ATAD5	5.20e-04	146	48	3	035393166f3ad5ab95602a8ae11b7d0ee4b1d691
ToppCell	Adult-Mesenchymal-chondrocyte-D122\|Adult / Lineage, Cell type, age group and donor	CACNA1C CACNA1D PPFIA2	5.41e-04	148	48	3	81a1e6fdd942a612bf523c59b8b4974f6ca1fdce
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Syt6\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ERFE TBATA TPPP3	5.63e-04	150	48	3	9d5bbdca19da60e1a2121ef64ec8e1375a5dbf6d
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SESTD1 OPTN CBLB	5.85e-04	152	48	3	405d19b290232bb3e564d61c0cff0cfdd247bdff
ToppCell	frontal_cortex\|World / Per Region, Lineage, Cell class, Cell type, Cell subtype	TBATA TPPP3 ASS1	5.85e-04	152	48	3	f9c29d4568402ca07a717dbffb3ccc7f35c5fe56
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SESTD1 OPTN CBLB	5.85e-04	152	48	3	06fa7d8acc8f56de00af9bee17884595b300410e
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	ERFE TBATA TPPP3	5.96e-04	153	48	3	b37a1ecad389d2848b8ca4d287823e8048207420
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	SESTD1 OPTN CBLB	5.96e-04	153	48	3	b101cb1bce5db785dab46b6c4f7be9c3efe48b0e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SESTD1 OPTN CBLB	5.96e-04	153	48	3	487388082bb596809ba1caf9197626b6814792ab
ToppCell	COVID-19_Severe-Lymphoid_T/NK-dn_T\|COVID-19_Severe / Disease group, lineage and cell class	SESTD1 OPTN CBLB	6.31e-04	156	48	3	83f25683e0f55472b56f915ee176fc05efc33a31
ToppCell	367C-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	CACNA1C FAM228B ASS1	6.31e-04	156	48	3	0b3630fd4479291599e1674e87eba6f93877ac3a
ToppCell	(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)\|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MXRA5 DNAJC1 RGS6	6.43e-04	157	48	3	84f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-myeloid_leukocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP36 TBATA TPPP3	6.54e-04	158	48	3	90ca742739a208d457db087655ba3d1c18a9da57
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C RGS6 PPFIA2	6.54e-04	158	48	3	84c0a215dabf697ada036c2b9592d0c61b5077de
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	GRK7 CHD5 ASS1	6.67e-04	159	48	3	a710551512aa0b7a281a81bea651a43c9f3b3539
ToppCell	P15-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MAP3K9 MAP3K21 PPFIA2	6.67e-04	159	48	3	a4bfd59c53237964fc24a24de5c1925fdd01db99
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP36 TBATA TPPP3	6.79e-04	160	48	3	e9e52532131cdc3fb01e81cfc046e3f670cc8e75
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	CACNA1C RGS6 PPFIA2	6.79e-04	160	48	3	fd14dfeb7021a4b7299371854dc8fc1fd66c8dae
ToppCell	droplet-Liver-LIVER_NPC-30m-Myeloid-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	USP36 TBATA TPPP3	6.79e-04	160	48	3	8dae9b0cf90a09acb196223f45a14680102630b2
ToppCell	RV-13._Vascular_Smooth_Muscle\|RV / Chamber and Cluster_Paper	CACNA1C PAWR PPFIA2	6.91e-04	161	48	3	47b3b7662cbb671ccc086dc0a0cabd65f63eb5a1
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K9 CIT CHD5	6.91e-04	161	48	3	69f5e759c0925daa37e0177a9cc3154842906bf6
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SESTD1 HECTD1 PPFIA2	7.04e-04	162	48	3	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C RGS6 TUB	7.16e-04	163	48	3	8f24cef152f5965727bbeee116bd26c75cbba82a
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CLSPN CIT ATAD5	7.29e-04	164	48	3	fb18b863152fb3109e2224c791c84c6371680a4e
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K9 CIT CHD5	7.42e-04	165	48	3	02cd87dfa2ca40e13455a4b9308477e82f76289b
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP3K9 CIT CHD5	7.42e-04	165	48	3	6d8b5669eee9b0903c9260fea707d186c9d7fefa
ToppCell	LV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	CACNA1C PAWR RGS6	7.42e-04	165	48	3	f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TBATA PPP3R1 PPFIA2	7.82e-04	168	48	3	6db453cbbbaf4144a86fadcfa5805d33396713b5
ToppCell	LPS-IL1RA+antiTNF-Endothelial-Endothelial-FOXM1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLSPN CIT ATAD5	7.95e-04	169	48	3	e0607af8ae8609d43e26ff2a2cab92650bfcd5b7
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	CACNA1D ERFE FOXA3	8.09e-04	170	48	3	d682178d11d67eb5a02d0c6b3967645e37bcc62a
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C RGS6 NOTCH2	8.23e-04	171	48	3	4ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ERFE ATAD5 CHD5	8.23e-04	171	48	3	845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell	TCGA-Cervix-Primary_Tumor-Endocervical_Adenocarcinoma-Mucinous_Adenocarcinoma\|TCGA-Cervix / Sample_Type by Project: Shred V9	CACNA1D ERFE FOXA3	8.23e-04	171	48	3	1af575809b3334bfaa019ff26c56e6cb03c82ee8
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	CACNA1C PAWR RGS6	8.23e-04	171	48	3	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLSPN CIT ATAD5	8.37e-04	172	48	3	2b6cd84c946b1e800caba452ae70145ea285fec1
ToppCell	367C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|367C / Donor, Lineage, Cell class and subclass (all cells)	CLSPN CIT ATAD5	8.37e-04	172	48	3	8d20eda599abf1e9e3e3b90f314acddee6a465a4
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_G2M\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLSPN CHD5 ASS1	8.37e-04	172	48	3	1171e754fd503a0c1152162fcc12a115088a08c7
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SESTD1 CLSPN NOTCH2	8.37e-04	172	48	3	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CLSPN CIT ATAD5	8.37e-04	172	48	3	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD4 OPTN CLSPN	8.51e-04	173	48	3	a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD4 OPTN CLSPN	8.51e-04	173	48	3	639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	CACNA1C PPFIA2 CHD5	8.51e-04	173	48	3	a5331721bd9f9a66530dd4ffe28cb3a5a8cad8fc
ToppCell	Children_(3_yrs)-Mesenchymal-vascular_smooth_muscle_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1C RGS6 PPFIA2	8.51e-04	173	48	3	5416b092321c7d9b63f0418c60f2402a138355bf
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Epithelial-epithelial_progenitor_cell-Distal_progenitor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CACNA1D MAP3K21 FOXA3	8.51e-04	173	48	3	81c36b9fe02c59099f080b2db02f4eaf2783911f
ToppCell	E16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-ASMC-ASMC_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ERFE TBATA RGS6	8.65e-04	174	48	3	7fb7bdf62563f2102fb38618b503eb2817b6594f
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NBPF10 CLSPN ATAD5	8.65e-04	174	48	3	c26eac176e9b0cba385630fdc60e0314a4e4caac
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C ERFE RGS6	8.65e-04	174	48	3	015d3742d3d79a57413a333f00ef2d380a9848dd
ToppCell	COVID-19-Heart-VSMC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CACNA1C RGS6 PPFIA2	8.80e-04	175	48	3	1125f0d3a5b2388fa77a820dea0288e824d84a82
ToppCell	Pericytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	CACNA1C RGS6 PPFIA2	8.80e-04	175	48	3	ddf721023a7afc8085c5de17aa254a6575444c0f
ToppCell	PND14-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_prolif\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLSPN CIT ATAD5	8.94e-04	176	48	3	9e719e6323597ecfc758c957256872cd4ae24d4d
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CLSPN CIT ATAD5	9.09e-04	177	48	3	8a74f5e72de605774111057bd87a7e7e4a6385cd
ToppCell	368C-Lymphocytic-CD4_T-cell-Proliferating_T_cell\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	NBPF10 CIT ATAD5	9.09e-04	177	48	3	844017225e9039d1bc621a9630a30c2e9a51b36d
ToppCell	Fetal_29-31_weeks-Mesenchymal-vascular_smooth_muscle_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CACNA1C RGS6 PPFIA2	9.24e-04	178	48	3	066dbc4cc2083c549d98122ed44707127f34d582
ToppCell	droplet-Limb_Muscle-MUSCLE-30m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD11 ZBED6 BTBD7	9.24e-04	178	48	3	01dafd19de04eff459253eaa9a35debf8f3deedf
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLSPN CIT ATAD5	9.24e-04	178	48	3	dbde3305e0c6a81593fe614e3f2e746b32cc16a7
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PPP3R1 CIT CHD5	9.39e-04	179	48	3	a3922476f33d2e4137a12dbda21a1703dff79684
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	S100Z CLSPN CIT	9.39e-04	179	48	3	ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCell	droplet-Lung-21m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SESTD1 CBLB CIT	9.39e-04	179	48	3	4f20540bfbcefe0e83812be7ea542e8bb3bf19bc
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c11-MKI67-FOS\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	CLSPN CIT ATAD5	9.39e-04	179	48	3	ac987c9425a1b4106d1b8779a2c5461383eae2ae
ToppCell	Multiple_Sclerosis-Other-RBC\|Multiple_Sclerosis / Disease, Lineage and Cell Type	OPTN RGS6 BAG1	9.39e-04	179	48	3	15763dc59ee6186416e203ffbb450ae4608eba59
ToppCell	normal_Lymph_Node-T/NK_cells-Exhausted_CD8+_T\|normal_Lymph_Node / Location, Cell class and cell subclass	OPTN GTF3C1 CBLB	9.39e-04	179	48	3	3dc929a10381b7d86650c6cd8f354892fe1d93e7
ToppCell	LPS-IL1RA-Endothelial-Endothelial-FOXM1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CLSPN CIT ATAD5	9.54e-04	180	48	3	334e2b1f6eb7d4ece20b1c7b02107863f913237f
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1D FOXA3 ARHGAP36	9.70e-04	181	48	3	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	RA-07._Pericyte\|RA / Chamber and Cluster_Paper	CACNA1C PAWR PPFIA2	9.70e-04	181	48	3	8dfb42d096db6c2df9b41303a7199d134d4bff07
ToppCell	Healthy_Control-Lymphoid-T-\|Healthy_Control / Condition, Lineage, Cell class and cell subclass	ERFE CLSPN CIT	9.70e-04	181	48	3	ac1ee313910c05b1b3cb497bae14565464919c21
ToppCell	facs-Large_Intestine-Proximal-18m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CLSPN NDUFB7 PRRC2A	9.70e-04	181	48	3	9fce5eee75684a7ecac6996e26e9215bc95098b2
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CLSPN CIT ASS1	9.70e-04	181	48	3	74311aac2fe27dc02a9be3bc20e0c7ef1c239049
Drug	L-Arg-L-phe	CIT ASS1	1.30e-05	3	48	2	CID000150964
Drug	NSC-686960	CACNA1C CACNA1D	2.60e-05	4	48	2	CID000192816
Drug	Nilvadipine	CACNA1C CACNA1D	4.33e-05	5	48	2	DB06712
Drug	Nisoldipine	CACNA1C CACNA1D	4.33e-05	5	48	2	DB00401
Drug	B 874-67	CACNA1C CACNA1D	4.33e-05	5	48	2	CID000195466
Drug	methyl beta-aminocrotonate	CACNA1C CACNA1D	4.33e-05	5	48	2	CID000084253
Drug	nemadipine-A	CACNA1C CACNA1D	4.33e-05	5	48	2	CID002856102
Drug	2-propylpentanoic acid; Up 200; 200uM; MCF7; HT_HG-U133A_EA	CACNA1D OPTN ATAD5 BTBD7 SOS2	5.04e-05	191	48	5	994_UP
Drug	(R) -Naproxen sodium salt [26159-34-2]; Down 200; 15.8uM; MCF7; HT_HG-U133A	USP36 MAP3K9 PPP3R1 BTBD7 SOS2	5.42e-05	194	48	5	6794_DN
Drug	Isopropamide iodide [71-81-8]; Down 200; 8.4uM; MCF7; HT_HG-U133A	PAWR PPP3R1 BTBD7 NOTCH2 SOS2	5.83e-05	197	48	5	6781_DN
Drug	CPU-23	CACNA1C CACNA1D	6.49e-05	6	48	2	CID003036051
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1D	1.55e-05	4	48	2	DOID:0060173 (implicated_via_orthology)
Disease	resting heart rate	CACNA1C CACNA1D RGS6 PPFIA2	1.02e-04	149	48	4	EFO_0004351
Disease	Calcium channel blocker use measurement	CACNA1C KDM2B CACNA1D SOS2	4.00e-04	213	48	4	EFO_0009930
Disease	cardiovascular disease	USP36 KDM2B CACNA1D UBN1 SOS2	8.63e-04	457	48	5	EFO_0000319
Disease	Uterine leiomyoma, breast carcinoma	DNAJC1 ATAD5	1.25e-03	32	48	2	EFO_0000305, HP_0000131
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1D	1.58e-03	36	48	2	DOID:11723 (implicated_via_orthology)
Disease	body weights and measures	MAP3K9 ATAD5	1.75e-03	38	48	2	EFO_0004324
Disease	sexual dimorphism measurement	USP36 ANKRD11 DNAJC1 TPPP3 UBN1 ATAD5 ASS1	1.96e-03	1106	48	7	EFO_0021796
Disease	Agents acting on the renin-angiotensin system use measurement	CACNA1C KDM2B CACNA1D SOS2	2.14e-03	335	48	4	EFO_0009931
Disease	Mood Disorders	CACNA1C CACNA1D RGS6	2.60e-03	168	48	3	C0525045
Disease	Diuretic use measurement	KDM2B CACNA1D SOS2	2.64e-03	169	48	3	EFO_0009928
Disease	Schizophrenia	CACNA1C KDM2B PAWR CHD4 PPP3R1 BAG1	2.97e-03	883	48	6	C0036341

Protein segments in the cluster

Peptide	Gene	Start	Entry
KTEKLKEQGKSKRRF	ATAD5	1806	Q96QE3
KIKKRRQGELDGFLK	FAM228B	101	P0C875
KKRKKETKGREVRFG	ANKRD11	456	Q6UB99
EDTRLPKRLLKKGKK	CHD5	651	Q8TDI0
PKRLLKKGKKLRDDK	CHD5	656	Q8TDI0
DIFKKKKRKGQEDRK	C1orf131	236	Q8NDD1
FKDSRLKRKGLVKKV	BAG1	301	Q99933
DADEIKRLGKRFKKL	PPP3R1	16	P63098
ELLSRKKREKKKKTG	DNAJC1	181	Q96KC8
KKKGLFSRRKEDPAL	CIT	1236	O14578
EARKKALKLGAKKVF	ASS1	46	P00966
KGKGQIEKRKLREKR	PAWR	146	Q96IZ0
ALLKKGKFGKRESRK	ARHGAP36	386	Q6ZRI8
LLAKKKGKSLAGKRL	RGS6	451	P49758
KEAKDAKGSRRKKSL	NOTCH2	2121	Q04721
KLKDKDFGKQALRKE	MGAT4B	381	Q9UQ53
KKSKRAIRLFKEGKE	CBLB	116	Q13191
KRGKKKKRGRATDSF	MKNK2	61	Q9HBH9
KKRSRGKAKKLKFGL	ERFE	96	Q4G0M1
DGEKRKKRRGKKKVS	KIF3A	401	Q9Y496
RKKRREKKAAELAKG	NDUFB7	111	P17568
GKRGRKLKSKLEKTK	HECTD1	816	Q9ULT8
LKPGKEDKLFRKKRR	KDM2B	856	Q8NHM5
FRKFKKRKEQGLVGK	CACNA1C	1676	Q13936
SGLATLKKKFIKRRK	BTBD7	61	Q9P203
RLKKKGGEKMALLEK	GRK7	226	Q8WTQ7
EEGRPGKKLKKVKLR	CHD4	681	Q14839
FRKFKKRKEQGLVGK	CACNA1D	1616	Q01668
RKGKFRKSRLKLKDG	MAP3K9	501	P80192
KKKGIKSSIGRLFGK	PPFIA2	826	O75334
KSSIGRLFGKKEKAR	PPFIA2	831	O75334
KLKEELGKLKGKSER	OPTN	106	Q96CV9
LKKKGKDLINFSKRR	SOS2	946	Q07890
RKGKFKRSRLKLKDG	MAP3K21	496	Q5TCX8
DVDKIEKKGKGKKRR	NBPF10	3676	Q6P3W6
AKKEQKKGKGLRFKR	RPL7L1	46	Q6DKI1
KKGKGLRFKRLESFL	RPL7L1	51	Q6DKI1
DGIELGKSSKREKKK	NSUN7	531	Q8NE18
KRFKLEEKVKKGGSG	FOXA3	211	P55318
KRLDEKFGAPDKRLK	PRRC2A	491	P48634
KAELKLEKKSGRKPR	TBATA	16	Q96M53
KKKLAFLSGGKDRRS	SESTD1	11	Q86VW0
TAGKAKVKSKRRLEK	CLSPN	161	Q9HAW4
GKERKRFKLSKGELK	S100Z	21	Q8WXG8
KKALEELATKRFKGK	TPPP3	76	Q9BW30
RKKLILAKKFSKDLG	ZBED6	76	P86452
RKFEEKYGGKKRRKD	UBN1	106	Q9NPG3
LKPKELFKKAERKGK	PHF8	531	Q9UPP1
KKKGEFPGEKSKRLR	GTF3C1	1231	Q12789
EDGKKVFLLAGRKRK	TUB	291	P50607
FDRGKEKKIKKFKRE	USP36	1076	Q9P275
INGDKKAKKGRRKLK	MXRA5	731	Q9NR99