Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionsodium channel activity

GRIK4 HCN4 HCN1 SCN2A

1.79e-0652344GO:0005272
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH5 DNAH8 DNAH14

3.62e-0618343GO:0008569
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

GRIK4 SLC4A8 HCN4 HCN1 SCN2A

9.88e-06171345GO:0015081
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN4 HCN1 SCN2A

1.14e-0526343GO:0005248
GeneOntologyMolecularFunctiondynein light intermediate chain binding

DNAH5 DNAH8 DNAH14

1.44e-0528343GO:0051959
GeneOntologyMolecularFunctiondynein intermediate chain binding

DNAH5 DNAH8 DNAH14

3.37e-0537343GO:0045505
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

GRIK4 HCN4 CHRNA1 HCN1

9.12e-05140344GO:0099094
GeneOntologyMolecularFunctionintracellularly cAMP-activated cation channel activity

HCN4 HCN1

1.26e-0410342GO:0005222
GeneOntologyMolecularFunctionintracellularly cyclic nucleotide-activated monoatomic cation channel activity

HCN4 HCN1

2.17e-0413342GO:0005221
GeneOntologyMolecularFunctioncyclic nucleotide-activated monoatomic ion channel activity

HCN4 HCN1

2.17e-0413342GO:0043855
GeneOntologyMolecularFunctionmicrotubule motor activity

DNAH5 DNAH8 DNAH14

2.28e-0470343GO:0003777
GeneOntologyMolecularFunctiongated channel activity

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

2.37e-04334345GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

2.68e-04343345GO:0005261
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

GRIK4 HCN4 CHRNA1 HCN1

3.13e-04193344GO:0015276
GeneOntologyMolecularFunctionligand-gated channel activity

GRIK4 HCN4 CHRNA1 HCN1

3.38e-04197344GO:0022834
GeneOntologyMolecularFunctionadenylate cyclase activity

GUCY2F ADCY5

4.23e-0418342GO:0004016
GeneOntologyMolecularFunctionATP-dependent activity

MDN1 DNAH5 DNAH8 TAP2 SNRNP200 DNAH14

5.32e-04614346GO:0140657
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GRIK4 HTR4 CHRNA1

6.52e-04100343GO:0030594
GeneOntologyMolecularFunctioncyclase activity

GUCY2F ADCY5

7.59e-0424342GO:0009975
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

GRIK4 SLC4A8 HCN4 CHRNA1 HCN1 SCN2A

8.03e-04664346GO:0008324
GeneOntologyMolecularFunctionphosphorus-oxygen lyase activity

GUCY2F ADCY5

8.24e-0425342GO:0016849
GeneOntologyMolecularFunctioncAMP binding

HCN4 HCN1

8.24e-0425342GO:0030552
GeneOntologyMolecularFunctionATP hydrolysis activity

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

8.43e-04441345GO:0016887
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

1.01e-03459345GO:0005216
GeneOntologyMolecularFunctioncytoskeletal motor activity

DNAH5 DNAH8 DNAH14

1.05e-03118343GO:0003774
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

GRIK4 SLC4A8 HCN4 HCN1 SCN2A

1.07e-03465345GO:0046873
GeneOntologyMolecularFunctiontransporter activity

GRAMD1B GRIK4 SLC4A8 HCN4 TAP2 CHRNA1 HCN1 SCN2A

1.18e-031289348GO:0005215
GeneOntologyMolecularFunctionpotassium channel activity

GRIK4 HCN4 HCN1

1.33e-03128343GO:0005267
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

HCN4 HCN1

1.44e-0333342GO:0005217
GeneOntologyMolecularFunctionchannel activity

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

1.83e-03525345GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

1.84e-03526345GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

GRIK4 SLC4A8 HCN4 CHRNA1 HCN1 SCN2A

2.00e-03793346GO:0015075
GeneOntologyMolecularFunctioncyclic nucleotide binding

HCN4 HCN1

2.00e-0339342GO:0030551
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

GRIK4 HCN4 HCN1

2.84e-03167343GO:0015079
GeneOntologyMolecularFunctiontransmembrane transporter activity

GRIK4 SLC4A8 HCN4 TAP2 CHRNA1 HCN1 SCN2A

3.26e-031180347GO:0022857
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

HCN4 HCN1 SCN2A

3.62e-03182343GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

HCN4 HCN1 SCN2A

3.73e-03184343GO:0022832
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

GRIK4 SLC4A8 HCN4 HCN1 SCN2A

3.93e-03627345GO:0022890
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIK4 CHRNA1

4.24e-0357342GO:1904315
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIK4 CHRNA1

4.68e-0360342GO:0099529
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIK4 CHRNA1

5.47e-0365342GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIK4 CHRNA1

5.47e-0365342GO:0022824
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIK4 CHRNA1

7.22e-0375342GO:0098960
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GRIK4 CHRNA1

7.60e-0377342GO:0005230
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

GRIK4 SLC4A8 HCN4 HCN1 SCN2A

8.68e-03758345GO:0015318
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

9.51e-03775345GO:0017111
GeneOntologyMolecularFunctionglycosyltransferase activity

B3GALT5 DPY19L1 ST6GALNAC5

1.28e-02288343GO:0016757
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN4 HCN1

1.30e-02102342GO:0005249
GeneOntologyMolecularFunctionpyrophosphatase activity

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

1.31e-02839345GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

1.32e-02840345GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

1.32e-02840345GO:0016818
GeneOntologyBiologicalProcessaction potential

HCN4 CHRNA1 HCN1 SCN2A CNTNAP1

2.47e-05201365GO:0001508
GeneOntologyBiologicalProcesstransmission of nerve impulse

CHRNA1 HCN1 SCN2A CNTNAP1

4.24e-05112364GO:0019226
GeneOntologyBiologicalProcessregulation of membrane potential

GRIK4 SLC4A8 HCN4 CHRNA1 HCN1 SCN2A CNTNAP1

4.36e-05559367GO:0042391
GeneOntologyBiologicalProcessmembrane depolarization

HCN4 CHRNA1 HCN1 SCN2A

5.74e-05121364GO:0051899
GeneOntologyBiologicalProcessneuronal action potential

CHRNA1 HCN1 SCN2A

1.80e-0463363GO:0019228
GeneOntologyBiologicalProcessneuromuscular junction development

SPG11 CHRNA1 CNTNAP1

2.26e-0468363GO:0007528
GeneOntologyBiologicalProcesssinoatrial node development

BMP4 HCN4

2.28e-0413362GO:0003163
GeneOntologyCellularComponentHCN channel complex

HCN4 HCN1

1.73e-054362GO:0098855
GeneOntologyCellularComponentdynein complex

DNAH5 DNAH8 DNAH14

1.10e-0454363GO:0030286
GeneOntologyCellularComponentouter dynein arm

DNAH5 DNAH8

1.88e-0412362GO:0036157
GeneOntologyCellularComponentparanode region of axon

SCN2A CNTNAP1

3.86e-0417362GO:0033270
GeneOntologyCellularComponentmonoatomic ion channel complex

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

4.48e-04378365GO:0034702
GeneOntologyCellularComponentaxon terminus

GRIK4 SLC4A8 HCN4 HCN1

4.53e-04210364GO:0043679
GeneOntologyCellularComponentterminal bouton

GRIK4 SLC4A8 HCN4

6.00e-0496363GO:0043195
GeneOntologyCellularComponentneuron projection terminus

GRIK4 SLC4A8 HCN4 HCN1

6.70e-04233364GO:0044306
GeneOntologyCellularComponentcation channel complex

GRIK4 HCN4 HCN1 SCN2A

6.91e-04235364GO:0034703
GeneOntologyCellularComponentaxon

SPG11 GRIK4 SLC4A8 HCN4 HCN1 SCN2A CNTNAP1

7.05e-04891367GO:0030424
GeneOntologyCellularComponentpotassium channel complex

GRIK4 HCN4 HCN1

7.58e-04104363GO:0034705
GeneOntologyCellularComponentaxonemal dynein complex

DNAH5 DNAH8

8.44e-0425362GO:0005858
GeneOntologyCellularComponentsodium channel complex

GRIK4 SCN2A

1.14e-0329362GO:0034706
GeneOntologyCellularComponentpresynaptic membrane

GRIK4 SLC4A8 HCN1 SCN2A

1.27e-03277364GO:0042734
GeneOntologyCellularComponenttransmembrane transporter complex

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

1.91e-03523365GO:1902495
GeneOntologyCellularComponenttransporter complex

GRIK4 HCN4 CHRNA1 HCN1 SCN2A

2.38e-03550365GO:1990351
GeneOntologyCellularComponentglutamatergic synapse

GRIK4 SLC4A8 HTR4 HCN1 SCN2A CNTNAP1

2.50e-03817366GO:0098978
GeneOntologyCellularComponentmicrotubule associated complex

DNAH5 DNAH8 DNAH14

2.66e-03161363GO:0005875
GeneOntologyCellularComponentsynaptic membrane

GRIK4 SLC4A8 CHRNA1 HCN1 SCN2A

3.06e-03583365GO:0097060
GeneOntologyCellularComponentdendrite

SPG11 GRIK4 SLC4A8 HTR4 HCN4 HCN1

3.19e-03858366GO:0030425
GeneOntologyCellularComponentdendritic tree

SPG11 GRIK4 SLC4A8 HTR4 HCN4 HCN1

3.23e-03860366GO:0097447
GeneOntologyCellularComponentpresynapse

GRIK4 SLC4A8 HCN4 HCN1 SCN2A CNTNAP1

3.74e-03886366GO:0098793
GeneOntologyCellularComponentcilium

CEP104 DNAH5 DNAH8 GUCY2F ADCY5 DNAH14

3.99e-03898366GO:0005929
GeneOntologyCellularComponentdistal axon

GRIK4 SLC4A8 HCN4 HCN1

6.44e-03435364GO:0150034
MousePhenobrain atrophy

SPG11 DNAH5 CNTNAP1

1.61e-0525283MP:0012506
DomainATPase_dyneun-rel_AAA

MDN1 DNAH5 DNAH8

2.36e-0614363IPR011704
DomainDynein_heavy_chain_D4_dom

DNAH5 DNAH8 DNAH14

2.36e-0614363IPR024317
DomainDynein_HC_stalk

DNAH5 DNAH8 DNAH14

2.36e-0614363IPR024743
DomainMT

DNAH5 DNAH8 DNAH14

2.36e-0614363PF12777
DomainAAA_8

DNAH5 DNAH8 DNAH14

2.36e-0614363PF12780
DomainAAA_5

MDN1 DNAH5 DNAH8

2.36e-0614363PF07728
DomainDHC_fam

DNAH5 DNAH8 DNAH14

2.95e-0615363IPR026983
DomainDynein_heavy_dom

DNAH5 DNAH8 DNAH14

2.95e-0615363IPR004273
DomainDynein_heavy

DNAH5 DNAH8 DNAH14

2.95e-0615363PF03028
DomainAAA+_ATPase

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

7.90e-06144365IPR003593
DomainAAA

MDN1 DNAH5 DNAH8 TAP2 SNRNP200

7.90e-06144365SM00382
DomainIon_trans_N

HCN4 HCN1

2.16e-054362PF08412
DomainIon_trans_N

HCN4 HCN1

2.16e-054362IPR013621
DomainDynein_heavy_dom-1

DNAH5 DNAH8

1.00e-048362IPR013594
DomainDHC_N1

DNAH5 DNAH8

1.00e-048362PF08385
DomainK_chnl_volt-dep_EAG/ELK/ERG

HCN4 HCN1

3.24e-0414362IPR003938
DomainDynein_heavy_dom-2

DNAH5 DNAH8

3.24e-0414362IPR013602
DomainDHC_N2

DNAH5 DNAH8

3.24e-0414362PF08393
DomaincNMP-bd_CS

HCN4 HCN1

4.26e-0416362IPR018488
DomainA/G_cyclase_CS

GUCY2F ADCY5

4.82e-0417362IPR018297
DomainNucleotide_cyclase

GUCY2F ADCY5

5.42e-0418362IPR029787
Domain-

GUCY2F ADCY5

5.42e-04183623.30.70.1230
DomainGUANYLATE_CYCLASE_2

GUCY2F ADCY5

6.05e-0419362PS50125
DomainGUANYLATE_CYCLASE_1

GUCY2F ADCY5

6.05e-0419362PS00452
DomainA/G_cyclase

GUCY2F ADCY5

6.05e-0419362IPR001054
DomainCYCc

GUCY2F ADCY5

6.05e-0419362SM00044
DomainGuanylate_cyc

GUCY2F ADCY5

6.05e-0419362PF00211
DomainIon_trans_dom

HCN4 HCN1 SCN2A

1.37e-03114363IPR005821
DomainIon_trans

HCN4 HCN1 SCN2A

1.37e-03114363PF00520
DomainCNMP_BINDING_1

HCN4 HCN1

1.73e-0332362PS00888
DomainCNMP_BINDING_2

HCN4 HCN1

1.73e-0332362PS00889
DomaincNMP

HCN4 HCN1

1.95e-0334362SM00100
DomaincNMP_binding

HCN4 HCN1

1.95e-0334362PF00027
DomaincNMP-bd_dom

HCN4 HCN1

2.07e-0335362IPR000595
DomainCNMP_BINDING_3

HCN4 HCN1

2.07e-0335362PS50042
DomainANF_receptor

GRIK4 GUCY2F

2.31e-0337362PF01094
DomainANF_lig-bd_rcpt

GRIK4 GUCY2F

2.31e-0337362IPR001828
DomaincNMP-bd-like

HCN4 HCN1

2.43e-0338362IPR018490
DomainPeripla_BP_I

GRIK4 GUCY2F

2.56e-0339362IPR028082
Domain-

MDN1 DNAH5 DNAH8 TAP2 SNRNP200 DNAH14

2.78e-037463663.40.50.300
Domain-

HCN4 HCN1

3.85e-03483622.60.120.10
DomainRmlC-like_jellyroll

HCN4 HCN1

4.34e-0351362IPR014710
DomainP-loop_NTPase

MDN1 DNAH5 DNAH8 TAP2 SNRNP200 DNAH14

5.22e-03848366IPR027417
DomainLIM

LIMD1 WTIP

7.81e-0369362PF00412
Domain-

LIMD1 WTIP

8.03e-03703622.10.110.10
DomainLIM_DOMAIN_2

LIMD1 WTIP

8.26e-0371362PS50023
DomainZnf_LIM

LIMD1 WTIP

8.26e-0371362IPR001781
DomainLIM_DOMAIN_1

LIMD1 WTIP

8.26e-0371362PS00478
DomainLIM

LIMD1 WTIP

8.26e-0371362SM00132
Domain-

MDN1 COL6A6

8.94e-03743623.40.50.410
DomainVWFA

MDN1 COL6A6

1.09e-0282362PS50234
DomainVWA

MDN1 COL6A6

1.14e-0284362SM00327
Pubmed

Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.

HCN4 HCN1

1.10e-06237219135060
Pubmed

Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.

HCN4 HCN1

1.10e-06237217548059
Pubmed

Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.

HCN4 HCN1

1.10e-06237221456027
Pubmed

Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.

HCN4 HCN1

1.10e-06237211675786
Pubmed

EP3 activation facilitates bladder excitability via HCN channels on ICCs.

HCN4 HCN1

3.30e-06337228131828
Pubmed

HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.

HCN4 HCN1

3.30e-06337233181864
Pubmed

Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.

HCN4 HCN1

3.30e-06337222652004
Pubmed

Tension-dependent regulation of mammalian Hippo signaling through LIMD1.

LIMD1 WTIP

3.30e-06337229440237
Pubmed

Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.

HCN4 HCN1

3.30e-06337221187420
Pubmed

Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.

HCN4 HCN1

3.30e-06337221945247
Pubmed

Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.

HCN4 HCN1

3.30e-06337222006928
Pubmed

Functional expression of the human HCN3 channel.

HCN4 HCN1

6.60e-06437216043489
Pubmed

Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.

HCN4 HCN1

6.60e-06437222748890
Pubmed

Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.

HCN4 HCN1

6.60e-0643729630217
Pubmed

Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.

HCN4 HCN1

6.60e-0643729405696
Pubmed

Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.

HCN4 HCN1

6.60e-06437212928435
Pubmed

The Ajuba LIM domain protein is a corepressor for SNAG domain mediated repression and participates in nucleocytoplasmic Shuttling.

LIMD1 WTIP

6.60e-06437217909014
Pubmed

Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.

HCN4 HCN1

6.60e-06437221615589
Pubmed

Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.

HCN4 HCN1

6.60e-06437220140458
Pubmed

Spatiotemporal regulation of the GPCR activity of BAI3 by C1qL4 and Stabilin-2 controls myoblast fusion.

GRIK4 STAB2

6.60e-06437230367035
Pubmed

Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.

HCN4 HCN1

1.10e-05537234429357
Pubmed

Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.

HCN4 HCN1

1.10e-05537215564593
Pubmed

Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.

LIMD1 WTIP

1.65e-05637220303269
Pubmed

Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.

HCN4 HCN1

1.65e-05637225761792
Pubmed

Ajuba LIM proteins are snail/slug corepressors required for neural crest development in Xenopus.

LIMD1 WTIP

1.65e-05637218331720
Pubmed

Multiple mouse chromosomal loci for dynein-based motility.

DNAH5 DNAH8 DNAH14

1.74e-05473738812413
Pubmed

LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.

LIMD1 WTIP

2.30e-05737220133701
Pubmed

Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins.

LIMD1 WTIP

2.30e-05737228683311
Pubmed

Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.

HCN4 HCN1

2.30e-05737219421833
Pubmed

Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.

DNAH5 DNAH8

2.30e-05737231178125
Pubmed

Isolation of several human axonemal dynein heavy chain genes: genomic structure of the catalytic site, phylogenetic analysis and chromosomal assignment.

DNAH5 DNAH8

2.30e-0573729256245
Pubmed

Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.

DNAH5 WDFY4

3.07e-05837217903303
Pubmed

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

LIMD1 WTIP

3.95e-05937220616046
Pubmed

International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.

HCN4 HCN1

4.93e-051037216382102
Pubmed

Polydactyly and ectopic ZPA formation in Alx-4 mutant mice.

BMP4 CHRNA1

6.02e-05113729374397
Pubmed

Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.

HCN4 HCN1

7.22e-051237217482496
Pubmed

A local Wnt-3a signal is required for development of the mammalian hippocampus.

BMP4 GRIK4

7.22e-051237210631167
Pubmed

Loss of migfilin expression has no overt consequences on murine development and homeostasis.

LIMD1 WTIP

8.53e-051337221224394
Pubmed

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

LIMD1 WTIP

8.53e-051337222286099
Pubmed

WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.

SCN2A CNTNAP1

8.53e-051337216723544
Pubmed

Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.

HCN4 HCN1

9.94e-051437229107716
Pubmed

The short stature homeobox 2 (Shox2)-bone morphogenetic protein (BMP) pathway regulates dorsal mesenchymal protrusion development and its temporary function as a pacemaker during cardiogenesis.

BMP4 HCN4

9.94e-051437225488669
Pubmed

Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.

DNAH5 DNAH8

9.94e-05143729373155
Pubmed

Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.

HCN4 HCN1

1.15e-041537221147989
Pubmed

Control of sinus venous valve and sinoatrial node development by endocardial NOTCH1.

BMP4 HCN4

1.31e-041637231591643
Pubmed

Dorsoventral patterning of the telencephalon is disrupted in the mouse mutant extra-toes(J).

BMP4 GRIK4

1.48e-041737210625551
Pubmed

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.

SCN2A CNTNAP1

1.67e-041837237321992
Pubmed

Embryonic Cul4b is important for epiblast growth and location of primitive streak layer cells.

CUL4B BMP4

1.67e-041837231260508
Pubmed

Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.

HCN4 HCN1

1.67e-041837227180262
Pubmed

Wt1 and retinoic acid signaling in the subcoelomic mesenchyme control the development of the pleuropericardial membranes and the sinus horns.

BMP4 HCN4

1.86e-041937220185795
Pubmed

LIM-homeodomain gene Lhx2 regulates the formation of the cortical hem.

BMP4 GRIK4

1.86e-041937211165475
Pubmed

The formation and function of the cardiac conduction system.

BMP4 HCN4

2.28e-042137226786210
Pubmed

Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.

HCN4 HCN1

2.28e-042137230270038
Pubmed

DMRT5 Together with DMRT3 Directly Controls Hippocampus Development and Neocortical Area Map Formation.

BMP4 GRIK4

2.75e-042337228031177
Pubmed

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

GRIK4 HTR4 CHRNA1 CNTNAP1

2.86e-0430037419086053
Pubmed

Patterning the dorsal telencephalon: a role for sonic hedgehog?

BMP4 GRIK4

3.25e-042537217959802
Pubmed

Regulation of archicortical arealization by the transcription factor Zbtb20.

BMP4 GRIK4

4.09e-042837222689450
Pubmed

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.

LIMD1 WTIP

4.39e-042937221834987
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SLC4A8 MDN1 HCN4 WTIP HCN1 CNTNAP1

4.95e-0496337628671696
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

CEP104 ADCY5 HCN1 CNTNAP1

4.96e-0434737417114649
Pubmed

Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation.

BMP4 HCN4

5.02e-043137221757651
Pubmed

Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.

HCN4 HCN1

5.02e-043137217473172
Pubmed

Primary Ciliary Dyskinesia

DNAH5 DNAH8

5.35e-043237220301301
Pubmed

Gene expression profiling in the developing secondary palate in the absence of Tbx1 function.

BMP4 CHRNA1

6.05e-043437229866044
Pubmed

Hes genes and neurogenin regulate non-neural versus neural fate specification in the dorsal telencephalic midline.

BMP4 GRIK4

7.56e-043837218579678
Pubmed

Cockayne syndrome group A and ferrochelatase finely tune ribosomal gene transcription and its response to UV irradiation.

CUL4B SNRNP200

9.23e-044237234581821
GeneFamilyDyneins, axonemal

DNAH5 DNAH8 DNAH14

2.49e-0617293536
GeneFamilyCyclic nucleotide gated channels

HCN4 HCN1

1.11e-0410292250
GeneFamilyLIM domain containing

LIMD1 WTIP

4.02e-03592921218
ToppCellfacs-Aorta-Heart-3m-Endothelial-endocardial_endothelial_cells|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC1B BMP4 STAB2 ST6GALNAC5

1.10e-05167374a4a795751644b22af616335379e64ae95175180c
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT5 HTR4 DPY19L1 ST6GALNAC5

1.21e-051713746a489a75eeab2a2d48d604682e93599c20a945fe
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR4 DPY19L1 DNAH14 ST6GALNAC5

1.23e-0517237492e76cbf4807704790f42cf2507e92f85cd3bc92
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR4 DPY19L1 FHIP1A DNAH14

1.29e-051743747d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DUOXA1 HCN4 HCN1 ST6GALNAC5

1.44e-051793748ce5000088b727783a0619baa16a2cd036d21f54
ToppCellCOVID-19-lung-AT1|lung / Disease (COVID-19 only), tissue and cell type

DUOXA1 FHIP1A DNAH14 ST6GALNAC5

1.57e-05183374942530449e9c6583705eeb8f6f12621daea57252
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 DNAH5 GUCY2F SCN2A

1.61e-05184374ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 DNAH5 GUCY2F SCN2A

1.61e-051843742cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 DNAH5 GUCY2F SCN2A

1.61e-051843742b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

C18orf63 DNAH8 HCN1 SCN2A

1.68e-0518637423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY5 HCN1 SCN2A CNTNAP1

1.79e-051893744dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCelldroplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADCY5 HCN1 SCN2A CNTNAP1

1.79e-051893740d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DUOXA1 DNAH5 FHIP1A DNAH14

1.90e-05192374cc9911e182a289779a2612bc213daae5607689e7
ToppCellAdult-Epithelial|Adult / Lineage, Cell type, age group and donor

DUOXA1 DNAH5 FHIP1A DNAH14

1.90e-05192374efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 LIMD1 WTIP ADCY5

1.94e-051933741043b28503bfaa0d5a82ec358bc86cbde73ea8f2
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 LIMD1 WTIP ADCY5

1.94e-051933740266a4fdf436d83ec1d9392abba8c6ec5166970a
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DUOXA1 FHIP1A DNAH14 ST6GALNAC5

1.98e-0519437453f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellnucseq-Epithelial|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

DUOXA1 DNAH5 FHIP1A DNAH14

2.02e-051953749406866f99555198a9be311fbd65751b70f35446
ToppCellIPF-Stromal-Myofibroblast|Stromal / Disease state, Lineage and Cell class

GRIK4 COL6A6 DNAH14 ST6GALNAC5

2.10e-05197374f304d42fc4936fe20996e07c8dccc698a6e5e5ef
ToppCellLPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

SLC4A8 DUOXA1 HCN4 DNAH5

2.19e-0519937415f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCellLPS_anti-TNF-Hematopoietic_Myeloid-Dendritic_cells-pDC|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

GRAMD1B LIMD1 WDFY4 CHRNA1

2.23e-052003746a34e07e6d77fe3fdd9ff44c4b1e46a023f6d6a2
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-early_pro-B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUOXA1 GUCY2F IL5

2.30e-041443731d05aa08603cba28c0c6511767e434c1f592a3aa
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-early_pro_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUOXA1 GUCY2F IL5

2.30e-04144373d3f6f5da56794367ee3776bfd3a9dcf893efe0f0
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-pDC|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAMD1B WDFY4 CHRNA1

2.70e-041523730c6dd41142e4ca1e54ca41e05e42ed29fbf0e570
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAMD1B WDFY4 CHRNA1

2.75e-04153373c81a88d3f707487c511020d3960a1c41e706c6a0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRIK4 HTR4 ST6GALNAC5

2.81e-0415437330cb4bb297fa815adb829f3b5cafca56fcbcb810
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell-Schwann_Cell_/_Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRIK4 HTR4 ST6GALNAC5

2.81e-04154373ade094e2947761a0a34daa8fcff3e9ea8437e4a5
ToppCellEpithelial-Epithelial-B_(AT1-AT2-progenitors)|Epithelial / shred on cell class and cell subclass (v4)

B3GALT5 MDN1 ST6GALNAC5

2.81e-04154373770712806e26f73456fb77a81aa4ef8ec78a21ea
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRIK4 HTR4 ST6GALNAC5

2.81e-0415437342bd8f88fd075a2d4edde394785decad88a2660a
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Neural-neural_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRIK4 HTR4 ST6GALNAC5

2.81e-041543736425d9861148586466febd6eceae1b1f9b9a14c1
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC1B GRIK4 HCN1

2.86e-0415537372a19a9ecfd13f6769c4b447d3ce01a855ec6ec7
ToppCellPND07-28-samps-Mesenchymal-Mesothelial-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CLEC1B B3GALT5 FHIP1A

2.91e-04156373605d95a900e1443d3f6aae163ef2e893d3293203
ToppCellPND07-28-samps-Mesenchymal-Mesothelial|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CLEC1B B3GALT5 FHIP1A

2.91e-04156373574f761962a7dd3308bd41fc529dd3ea1b8625f8
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 CHRNA1 ST6GALNAC5

3.08e-04159373e967b557fe6ae4879d36f62c0297cbf6a2ad1ce9
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

GRIK4 DNAH8 HCN1

3.08e-041593735335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DNAH8 CHRNA1 ST6GALNAC5

3.08e-041593739db971130509c62d439e0cab16588a4d994d7aa0
ToppCellCOVID_non-vent-Lymphocytic-Dendritic-pDC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

GRAMD1B WDFY4 FHIP1A

3.14e-0416037361f4cb4eb4313d8318aadbb99595a6cb7fd919f7
ToppCellCOVID_non-vent-Lymphocytic-Dendritic|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

GRAMD1B WDFY4 FHIP1A

3.14e-0416037334b4f710cfcb6ec370b8b074f3cbfe272f392cec
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells-pDC|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAMD1B WDFY4 CHRNA1

3.14e-04160373dee756a2dc9725520d439e7273c489c2284015d8
ToppCelldroplet-Lung-nan-3m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MDN1 DPY19L1 WDFY4

3.37e-04164373a67dd181eba275c191f4d0cab13df30eaa3ad913
ToppCelldroplet-Fat-Scat-21m|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUOXA1 COL6A6 IL5

3.43e-041653733f0c2486ea357d10dad0b703cf75cc29bdd5b5cf
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

WDFY4 DNAH8 SCN2A

3.49e-041663738de8f388f24436b84e19ef460476fdbda4d16abf
ToppCellNS-control-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

STAB2 WDFY4 ADCY5

3.49e-041663736d9fb239f69ba519844f593c00d515e1aac4ff50
ToppCellB_cells-pDCs|World / Immune cells in Kidney/Urine in Lupus Nephritis

GRAMD1B WDFY4 FHIP1A

3.62e-04168373dc8f94424f60ab56facdcffa969e7f3466ee1b6e
ToppCellASK440-Immune-B_cell|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq

CUL4B DUOXA1 COL6A6

3.62e-04168373127559d1a083c68cda9fce143afcc3eec168df17
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_ETV4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DPY19L1 FHIP1A DNAH14

3.68e-04169373716e9d4c5fb99c56b76afaa5ed90bfa859fde802
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 DNAH5 ADCY5

3.75e-0417037317bd7fd25a2657cb536ad47e294332920f759e95
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR4 DPY19L1 ST6GALNAC5

3.81e-04171373f648789e6aefe508bb748401bf9b3cd830fb0ddf
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L5-6_THEMIS_TMEM233|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK4 HTR4 DNAH14

3.81e-04171373fdd96c6fe850bd10e1e0d0f18c4401f8348b7d2c
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C18orf63 GRAMD1B SCN2A

3.94e-041733734bc6d93716f093b460c8b047199db8cab5fea720
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR4 DPY19L1 ST6GALNAC5

3.94e-041733735aa4d45a01d2d09eff8b4deb32bd91ab2471210a
ToppCellsevere-B_memory|severe / disease stage, cell group and cell class

WDFY4 CHRNA1 SCN2A

3.94e-041733733a987ac53a0136cc4c70ce8b901a15fc00c795e1
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GRIK4 DPY19L1 FHIP1A

3.94e-0417337395c723b09254ae7131fe5ba0841472502e83269b
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIK4 HCN4 DNAH8

4.01e-041743739d5dcd46cf346c381dea68ada6665f7fb68114a3
ToppCellfacs-Marrow-KLS-18m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRIK4 HCN4 DNAH8

4.01e-0417437353cec5c666c45278a71c21dd9c62a052a97e0fdf
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-Alox5+_Lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 DPY19L1 IL5

4.01e-04174373a8bd1fa08bf061a627529a38e5a23a68b6d80697
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_LCN15|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

B3GALT5 HTR4 DNAH14

4.01e-041743732947e5906b172d149412fa4e77476fce4ea695d2
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

COL6A6 FAM237B ADCY5

4.01e-041743734da79da7a09ee1e345102c5331675ebcdbe56171
ToppCellfacs-Lung-EPCAM-3m-Lymphocytic-lymphocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STAB2 DPY19L1 IL5

4.01e-041743737f8f6a15a823809effd37c1a5b09ef19b6d67755
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 WTIP CNTNAP1

4.08e-04175373d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCellnucseq-Immune-Immune_Myeloid-Myeloid_Dendritic-pDC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GRAMD1B WDFY4 FHIP1A

4.08e-0417537337c2d4e0b6e9a3171931797ce9a54f3347288e57
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Ccr7+_Dendritic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GRAMD1B SPG11 SLC4A8

4.08e-0417537391cb819a1786020713b7e64480de0545380daae9
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

GRAMD1B WDFY4 FHIP1A

4.08e-0417537397fe431f224b592b3076632d101e19136c138dcc
ToppCellfacs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC4A8 WTIP CNTNAP1

4.08e-04175373cf15465855602ba135752c18755e3e058dbd42ec
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D122|Adult / Lineage, Cell type, age group and donor

DUOXA1 DNAH5 FHIP1A

4.15e-041763733fee8a367bb9755aca1b7fcc968b08e51b6e9436
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC4A8 HCN1 SCN2A

4.15e-04176373116741fef5895ca85057d2d31eca9eba5764ab44
ToppCell3'-Child09-12-SmallIntestine-Epithelial-neuro-epithelial|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HCN4 HCN1 SCN2A

4.15e-041763732e1003dc373b14d27f0464d980453fdcfc1005f0
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-neurons_A-Branch_A1_(iMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC4A8 HCN1 SCN2A

4.15e-041763735b707f58d164ee7a6a527dd5d053472ce9a631c1
ToppCellLPS-IL1RA-Myeloid-Dendritic_cells|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

GRAMD1B WDFY4 CHRNA1

4.15e-04176373f3bbe8c1a8d132705eac360cf531261271d84588
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

HTR4 DPY19L1 ST6GALNAC5

4.22e-041773737e799333307448c6a94d1f33dbc59c543336f45e
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GRAMD1B WDFY4 FHIP1A

4.36e-04179373124da6f882968dc0d05f3edd8f3b4d61617cc214
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GRAMD1B WDFY4 FHIP1A

4.36e-04179373edc5ef693dc4e7ea70717b77fb908fc784dce3a2
ToppCellTCGA-Liver-Solid_Tissue_Normal|TCGA-Liver / Sample_Type by Project: Shred V9

CLEC1B STAB2 COL6A6

4.36e-041793737046f0a426e45fe1b41a25721ee1e33f6fc7f9e3
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver|TCGA-Liver / Sample_Type by Project: Shred V9

CLEC1B STAB2 COL6A6

4.36e-041793730e22e840f43ca81a7543dcf33ec17a741cdf7f37
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue|TCGA-Liver / Sample_Type by Project: Shred V9

CLEC1B STAB2 COL6A6

4.36e-0417937317ba1eedb6ebf039d3b11d099351d0ac6363c8d1
ToppCellE16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC4A8 WTIP ADCY5

4.36e-04179373adf8b025032a03dbb58871a92025cd7efbeb22ff
ToppCellTCGA-Liver-Solid_Tissue_Normal-Liver-Liver_normal_tissue-2|TCGA-Liver / Sample_Type by Project: Shred V9

CLEC1B STAB2 COL6A6

4.36e-04179373a20bb3ace5be10c5aef330e9268c0ba55f8fee23
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMD1 WTIP ADCY5

4.43e-0418037378fdcfb3fdbf36469cae78407cda5bd0996930d8
ToppCellE18.5-samps-Mesenchymal-Pericyte|E18.5-samps / Age Group, Lineage, Cell class and subclass

SLC4A8 COL6A6 ADCY5

4.43e-041803730b1d370db64862fe1c7ea0ffaf06d03ec82e6e70
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HCN4 FHIP1A HCN1

4.43e-04180373d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DPY19L1 FHIP1A DNAH14

4.50e-04181373576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

C18orf63 GRAMD1B SCN2A

4.50e-04181373e0abf2707d9e0aa942c657eef7d2cbcd02f060dd
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

HCN4 HCN1 SCN2A

4.57e-0418237357bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellfacs-Skin-Anagen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLEC1B BMP4 SLC4A8

4.57e-0418237322d6f4790950508e8aa27e02a8133af5f53f13c8
ToppCellnormal-na-Lymphocytic_B-B_mem-male|normal / PBMC cell types (v2) per disease, treatment status, and sex

WDFY4 DNAH8 ST6GALNAC5

4.57e-04182373ee36ea6cb9a5a08aeb83f2b7a249255f0b1a9870
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMD1 COL6A6 WTIP

4.57e-04182373ffe500d78a89dc6b4d05bab1664e7f30c94fb8d9
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GRAMD1B WDFY4 FHIP1A

4.65e-04183373df6fd0927b6e4cf9a1583969a68096e4bccfbace
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Dendritic-plasmacytoid_dendritic_cell-DC_c4-LILRA4|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GRAMD1B WDFY4 FHIP1A

4.65e-041833733b123571e10c132227aff65648b4b3c6acb4bd00
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-Pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMD1 COL6A6 WTIP

4.72e-0418437394748f63947db79a6b4540e3090a63689fdd9452
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

DUOXA1 DNAH5 FHIP1A

4.72e-04184373102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellE17.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

SLC4A8 COL6A6 FAM237B

4.72e-04184373607b55022de21ddb6a2d75e085df76df7abf6624
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Mesenchymal-brain_pericyte|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMD1 COL6A6 WTIP

4.72e-04184373819b277ecced7b415e363c7e7ddbc6f3b2d296de
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIMD1 WTIP ADCY5

4.72e-04184373f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WDFY4 HCN1 SCN2A

4.79e-04185373c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_memory-B_memory-3|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

WDFY4 DNAH8 CHRNA1

4.79e-0418537305e6eb78ead81268c1656e7ffe34f9cb7329b908
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-24m-Epithelial-neuroepithelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

BMP4 DNAH5 FHIP1A

4.79e-0418537305bc89a566b0db90ae06506e067190a4739a0974
ToppCellHealthy_donor-pDC|Healthy_donor / disease group, cell group and cell class (v2)

GRAMD1B WDFY4 FHIP1A

4.79e-041853737fbb55cbdb39bdecb6063c8ba9776ab06c2666e8
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

DUOXA1 DNAH5 FHIP1A

4.79e-04185373cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellPBMC-Severe-Myeloid-pDC-pDC|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GRAMD1B WDFY4 FHIP1A

4.87e-04186373b70cd94c651b56dcf2e55554533a5f1130845390
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

DNAH5 FHIP1A DNAH14

4.87e-041863732ea5ff14861e5f91d0e6a5767c403a24045d715c
Drug4-ethylsulfonylnaphthalene-1-sulfonamide

BMP4 HTR4 HCN4 HCN1 SCN2A

1.21e-06123355CID000013296
Diseasesick sinus syndrome (implicated_via_orthology)

HCN4 HCN1

3.86e-063342DOID:13884 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

HCN1 SCN2A

4.62e-059342C3502809
Diseasepeptic esophagitis (biomarker_via_orthology)

BMP4 IL5

8.44e-0512342DOID:13976 (biomarker_via_orthology)
Diseaseforced expiratory volume, response to bronchodilator

GRIK4 DPY19L1 HCN4 DNAH5 CHRNA1

1.48e-04445345EFO_0004314, GO_0097366
Diseaseanxiety disorder (implicated_via_orthology)

HCN1 SCN2A

2.93e-0422342DOID:2030 (implicated_via_orthology)
DiseaseAbnormality of refraction

GRAMD1B BMP4 ADCY5 HCN1 SCN2A

9.78e-04673345HP_0000539
Diseasediet measurement

SLC4A8 DPY19L1 DNAH5 HCN1 DNAH14 SCN2A

1.14e-031049346EFO_0008111

Protein segments in the cluster

PeptideGeneStartEntry
MMHLRLFCILLAAVS

CNTNAP1

1

P78357
MRLMYICLLVLGALC

B3GALT5

6

Q9Y2C3
MAVLVLVCLVMLAFH

ADCY5

246

O95622
RMLMVVLLCQVLLGG

BMP4

6

P12644
ICFSLVLLVILNMML

GRAMD1B

631

Q3KR37
MDHILLGVFMLVCII

CHRNA1

426

P02708
RLQMLLVFHCHVLLM

MDN1

3886

Q9NU22
LLMVLLSTIFMHGNR

MAGEB17

201

A8MXT2
RCFLCGHLIMDMILQ

LIMD1

536

Q9UGP4
HLIMRIMDCVLLLFQ

DNAH8

3181

Q96JB1
MNILMLTFIICGLLT

DEFB125

1

Q8N687
ILIMRLKLFLTPHMC

DPY19L1

466

Q2PZI1
VRIVNLIGMMLLLCH

HCN4

416

Q9Y3Q4
VHLAMSQMGLLARLL

CEP104

581

O60308
LVLRYLIPCNHMMLS

FHIP1A

406

Q05DH4
VRIFNLIGMMLLLCH

HCN1

296

O60741
MRMLLHLSLLALGAA

IL5

1

P05113
RIRIIIMCMHSALIG

GUCY2F

241

P51841
LMAILGNLLVMVAVC

HTR4

31

Q13639
MRCQMLVPVLSLHIG

DNAH14

11

Q0VDD8
VLICGLIVAIFMAML

GRIK4

811

Q16099
LHLGCMMLINLVNAD

FAM237B

11

A0A1B0GVD1
CVLLGLAMAVAHRMQ

DUOXA1

261

Q1HG43
MKMCRQLLFLHQDIL

C18orf63

41

Q68DL7
HCRQMIMIRSIFLFL

CUL4B

296

Q13620
MMLLILFLVIICSHI

COL6A6

1

A6NMZ7
PHLIMRIMDCVLLLF

DNAH5

3316

Q8TE73
RVLHLGVQMLMLSCG

TAP2

381

Q03519
MKTLMRHGLAVCLAL

ST6GALNAC5

1

Q9BVH7
YHLDLLMVAIMLGVC

SLC4A8

821

Q2Y0W8
RVMALILLILCVGMV

CLEC1B

31

Q9P126
TMLINLGRHKLMDCI

SPG11

2311

Q96JI7
LVHSLFNMLIMCTIL

SCN2A

126

Q99250
LMQHICGYQIMAFLL

WDFY4

1411

Q6ZS81
MMLQHLVIFCLGLVV

STAB2

1

Q8WWQ8
LRQHRMMILYCTLLA

SNRNP200

321

O75643
SVCGHLIMEMILQAL

WTIP

291

A6NIX2