Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	CARM1 KMT2C SMYD1	9.32e-05	44	40	3	GO:0140938
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	1.74e-04	10	40	2	GO:0001849
GeneOntologyMolecularFunction	histone H3K4 trimethyltransferase activity	KMT2C SMYD1	1.74e-04	10	40	2	GO:0140999
GeneOntologyMolecularFunction	histone methyltransferase activity	CARM1 KMT2C SMYD1	3.87e-04	71	40	3	GO:0042054
GeneOntologyMolecularFunction	amino acid binding	CAD NOS2 DDC	4.20e-04	73	40	3	GO:0016597
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	KMT2C SMYD1	7.27e-04	20	40	2	GO:0042800
GeneOntologyMolecularFunction	transferase activity, transferring one-carbon groups	CARM1 KMT2C CAD SMYD1	1.03e-03	224	40	4	GO:0016741
GeneOntologyMolecularFunction	histone modifying activity	CARM1 KDM2B KMT2C SMYD1	1.11e-03	229	40	4	GO:0140993
GeneOntologyMolecularFunction	opsonin binding	C4A C4B	1.14e-03	25	40	2	GO:0001846
GeneOntologyMolecularFunction	protein methyltransferase activity	CARM1 KMT2C SMYD1	1.15e-03	103	40	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	CARM1 KMT2C SMYD1	1.21e-03	105	40	3	GO:0008170
GeneOntologyMolecularFunction	complement binding	C4A C4B	1.87e-03	32	40	2	GO:0001848
GeneOntologyMolecularFunction	chromatin-protein adaptor activity	TOPBP1 PHF14	3.05e-03	41	40	2	GO:0140463
GeneOntologyMolecularFunction	small GTPase binding	FMNL3 DOCK10 CYFIP1 WDR44	3.80e-03	321	40	4	GO:0031267
GeneOntologyMolecularFunction	S-adenosylmethionine-dependent methyltransferase activity	CARM1 KMT2C SMYD1	4.91e-03	172	40	3	GO:0008757
GeneOntologyMolecularFunction	Hsp90 protein binding	HSF1 NOS2	5.43e-03	55	40	2	GO:0051879
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	C4A C4B SERPINB4	5.57e-03	180	40	3	GO:0004866
GeneOntologyMolecularFunction	GTPase binding	FMNL3 DOCK10 CYFIP1 WDR44	5.69e-03	360	40	4	GO:0051020
GeneOntologyMolecularFunction	peptidase inhibitor activity	C4A C4B SERPINB4	6.19e-03	187	40	3	GO:0030414
GeneOntologyMolecularFunction	endopeptidase regulator activity	C4A C4B SERPINB4	7.55e-03	201	40	3	GO:0061135
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	KMT2C SMYD1	8.20e-03	68	40	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	KMT2C SMYD1	8.43e-03	69	40	2	GO:0016278
GeneOntologyMolecularFunction	methyltransferase activity	CARM1 KMT2C SMYD1	8.85e-03	213	40	3	GO:0008168
GeneOntologyMolecularFunction	transferase activity, transferring sulphur-containing groups	CDK5RAP1 SULT1C4	9.65e-03	74	40	2	GO:0016782
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	9.92e-05	8	40	2	GO:0106139
GeneOntologyCellularComponent	other organism part	C4A C4B	1.27e-04	9	40	2	GO:0044217
GeneOntologyCellularComponent	terminal bouton	GRIK4 CAD CYFIP1	8.20e-04	96	40	3	GO:0043195
GeneOntologyCellularComponent	neuronal cell body	C4A C4B GRIK4 CAD CYFIP1 DDC VPS13A	9.32e-04	835	40	7	GO:0043025
Domain	Anaphylatoxin_comp_syst	C4A C4B	4.45e-05	5	40	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	4.45e-05	5	40	2	IPR001840
Domain	ANATO	C4A C4B	9.33e-05	7	40	2	SM00104
Domain	ANATO	C4A C4B	9.33e-05	7	40	2	PF01821
Domain	ANAPHYLATOXIN_2	C4A C4B	9.33e-05	7	40	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	9.33e-05	7	40	2	PS01177
Domain	Anaphylatoxin/fibulin	C4A C4B	9.33e-05	7	40	2	IPR000020
Domain	Thiol-ester_cl	C4A C4B	1.24e-04	8	40	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	1.24e-04	8	40	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	1.24e-04	8	40	2	IPR019742
Domain	A2M_N	C4A C4B	1.99e-04	10	40	2	PF01835
Domain	A2M_N	C4A C4B	1.99e-04	10	40	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	1.99e-04	10	40	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	1.99e-04	10	40	2	PS00477
Domain	A2M	C4A C4B	1.99e-04	10	40	2	PF00207
Domain	A2M_N_2	C4A C4B	1.99e-04	10	40	2	IPR011625
Domain	A2M_comp	C4A C4B	1.99e-04	10	40	2	IPR011626
Domain	A2M_N_2	C4A C4B	1.99e-04	10	40	2	PF07703
Domain	A2M_recep	C4A C4B	1.99e-04	10	40	2	PF07677
Domain	A2M_comp	C4A C4B	1.99e-04	10	40	2	PF07678
Domain	Macroglobln_a2	C4A C4B	1.99e-04	10	40	2	IPR001599
Domain	C345C	C4A C4B	5.96e-04	17	40	2	SM00643
Domain	Znf_PHD-finger	KDM2B KMT2C PHF14	6.43e-04	79	40	3	IPR019787
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	6.70e-04	18	40	2	IPR008930
Domain	NTR	C4A C4B	7.47e-04	19	40	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	7.47e-04	19	40	2	IPR018933
Domain	PHD	KDM2B KMT2C PHF14	9.10e-04	89	40	3	SM00249
Domain	Znf_PHD	KDM2B KMT2C PHF14	9.70e-04	91	40	3	IPR001965
Domain	EPHD	KMT2C PHF14	1.01e-03	22	40	2	PS51805
Domain	ZF_PHD_2	KDM2B KMT2C PHF14	1.10e-03	95	40	3	PS50016
Domain	NTR	C4A C4B	1.10e-03	23	40	2	PS50189
Domain	Netrin_domain	C4A C4B	1.10e-03	23	40	2	IPR001134
Domain	ZF_PHD_1	KDM2B KMT2C PHF14	1.13e-03	96	40	3	PS01359
Domain	TIMP-like_OB-fold	C4A C4B	1.41e-03	26	40	2	IPR008993
Domain	SET	KMT2C SMYD1	3.48e-03	41	40	2	PF00856
Domain	Znf_FYVE_PHD	KDM2B KMT2C PHF14	3.81e-03	147	40	3	IPR011011
Domain	SET	KMT2C SMYD1	4.36e-03	46	40	2	SM00317
Domain	SET_dom	KMT2C SMYD1	5.13e-03	50	40	2	IPR001214
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.11e-04	7	33	2	MM14685
Pathway	REACTOME_ACTIVATION_OF_C3_AND_C5	C4A C4B	1.47e-04	8	33	2	M27031
Pathway	KEGG_MEDICUS_REFERENCE_CLASSICAL_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	1.47e-04	8	33	2	M47872
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	2.88e-04	11	33	2	MM1430
Pathway	KEGG_MEDICUS_REFERENCE_LECTIN_PATHWAY_OF_COMPLEMENT_CASCADE_C4_C2_TO_C3_CONVERTASE_FORMATION	C4A C4B	2.88e-04	11	33	2	M47874
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	3.46e-04	12	33	2	MM1368
Pathway	WP_SIDS_SUSCEPTIBILITY_PATHWAYS	C4A C4B DDC	3.47e-04	59	33	3	MM15838
Pathway	WP_NITRIC_OXIDE_METABOLISM_IN_CYSTIC_FIBROSIS	CARM1 NOS2	4.08e-04	13	33	2	M39894
Pathway	BIOCARTA_LECTIN_PATHWAY	C4A C4B	4.08e-04	13	33	2	M4732
Pathway	BIOCARTA_CLASSIC_PATHWAY	C4A C4B	5.47e-04	15	33	2	M7146
Pathway	WP_COMPLEMENT_ACTIVATION_CLASSICAL_PATHWAY	C4A C4B	7.07e-04	17	33	2	MM15944
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	7.07e-04	17	33	2	MM1369
Pathway	BIOCARTA_COMP_PATHWAY	C4A C4B	9.83e-04	20	33	2	M917
Pathway	WP_COMPLEMENT_ACTIVATION	C4A C4B	1.19e-03	22	33	2	M39502
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	1.29e-06	2	40	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	1.29e-06	2	40	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	1.29e-06	2	40	2	15998580
Pubmed	C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.	C4A C4B	1.29e-06	2	40	2	25339671
Pubmed	A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.	C4A C4B	1.29e-06	2	40	2	17728371
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	1.29e-06	2	40	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	1.29e-06	2	40	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	1.29e-06	2	40	2	3696167
Pubmed	Structure and organization of the C4 genes.	C4A C4B	1.29e-06	2	40	2	6149580
Pubmed	Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.	C4A C4B	1.29e-06	2	40	2	6149581
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	1.29e-06	2	40	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	1.29e-06	2	40	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	1.29e-06	2	40	2	19933335
Pubmed	The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.	C4A C4B	1.29e-06	2	40	2	12115608
Pubmed	Biochemistry and biology of anaphylatoxins.	C4A C4B	1.29e-06	2	40	2	3542363
Pubmed	C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.	C4A C4B	1.29e-06	2	40	2	2387317
Pubmed	Promoter elements of the mouse complement C4 gene critical for transcription activation and start site location.	C4A C4B	1.29e-06	2	40	2	8132550
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	1.29e-06	2	40	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	1.29e-06	2	40	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	1.29e-06	2	40	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	1.29e-06	2	40	2	12207352
Pubmed	Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.	C4A C4B	1.29e-06	2	40	2	2395880
Pubmed	Effects of Complement C4 Gene Copy Number Variations, Size Dichotomy, and C4A Deficiency on Genetic Risk and Clinical Presentation of Systemic Lupus Erythematosus in East Asian Populations.	C4A C4B	1.29e-06	2	40	2	26814708
Pubmed	cDNA clone spanning the alpha-gamma subunit junction in the precursor of the murine fourth complement component (C4).	C4A C4B	1.29e-06	2	40	2	6192448
Pubmed	Complete primary structure of human C4a anaphylatoxin.	C4A C4B	1.29e-06	2	40	2	6167582
Pubmed	Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.	C4A C4B	1.29e-06	2	40	2	16908004
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	1.29e-06	2	40	2	30026462
Pubmed	Slp is an essential component of an EDTA-resistant activation pathway of mouse complement.	C4A C4B	1.29e-06	2	40	2	1438267
Pubmed	Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.	C4A C4B	1.29e-06	2	40	2	7365238
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	1.29e-06	2	40	2	6559257
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	1.29e-06	2	40	2	27758680
Pubmed	Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma.	C4A C4B	1.29e-06	2	40	2	19150565
Pubmed	Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.	C4A C4B	1.29e-06	2	40	2	7391573
Pubmed	Elevated levels of endogenous apoptotic DNA and IFN-alpha in complement C4-deficient mice: implications for induction of systemic lupus erythematosus.	C4A C4B	1.29e-06	2	40	2	17506029
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	1.29e-06	2	40	2	22387014
Pubmed	Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.	C4A C4B	1.29e-06	2	40	2	17971360
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	1.29e-06	2	40	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	1.29e-06	2	40	2	20506482
Pubmed	Low C4 gene copy numbers are associated with superior graft survival in patients transplanted with a deceased donor kidney.	C4A C4B	1.29e-06	2	40	2	23715124
Pubmed	Identification of the 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse complement C4 and Slp genes.	C4A C4B	1.29e-06	2	40	2	3464002
Pubmed	Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.	C4A C4B	1.29e-06	2	40	2	2993295
Pubmed	Clinical features of patients with homozygous complement C4A or C4B deficiency.	C4A C4B	1.29e-06	2	40	2	29928053
Pubmed	Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.	C4A C4B	1.29e-06	2	40	2	17971229
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	1.29e-06	2	40	2	12480675
Pubmed	Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.	C4A C4B	1.29e-06	2	40	2	6881182
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	1.29e-06	2	40	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	1.29e-06	2	40	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	1.29e-06	2	40	2	23918728
Pubmed	Identification of the site of sulfation of the fourth component of human complement.	C4A C4B	1.29e-06	2	40	2	3944109
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	1.29e-06	2	40	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	1.29e-06	2	40	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	1.29e-06	2	40	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	1.29e-06	2	40	2	4216347
Pubmed	Partial C4 deficiency in juvenile idiopathic arthritis patients.	C4A C4B	1.29e-06	2	40	2	17921792
Pubmed	Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.	C4A C4B	1.29e-06	2	40	2	21880985
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	1.29e-06	2	40	2	1699796
Pubmed	Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.	C4A C4B	1.29e-06	2	40	2	6978711
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	1.29e-06	2	40	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	1.29e-06	2	40	2	2997024
Pubmed	Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.	C4A C4B	1.29e-06	2	40	2	35898513
Pubmed	Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.	C4A C4B	1.29e-06	2	40	2	33353966
Pubmed	Sequence comparison of alleles of the fourth component of complement (C4) and sex-limited protein (Slp).	C4A C4B	1.29e-06	2	40	2	3008092
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	1.29e-06	2	40	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	1.29e-06	2	40	2	3624865
Pubmed	Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.	C4A C4B	1.29e-06	2	40	2	28873507
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	1.29e-06	2	40	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	1.29e-06	2	40	2	21857912
Pubmed	The molecular basis for the difference in immune hemolysis activity of the Chido and Rodgers isotypes of human complement component C4.	C4A C4B	1.29e-06	2	40	2	6609966
Pubmed	Heterogeneity and linkage of equine C4 and steroid 21-hydroxylase genes.	C4A C4B	1.29e-06	2	40	2	2900855
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	1.29e-06	2	40	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	1.29e-06	2	40	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	1.29e-06	2	40	2	4514997
Pubmed	Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.	C4A C4B	1.29e-06	2	40	2	276882
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	1.29e-06	2	40	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	1.29e-06	2	40	2	5919331
Pubmed	Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.	C4A C4B	1.29e-06	2	40	2	6832377
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	1.29e-06	2	40	2	3167981
Pubmed	Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.	C4A C4B	1.29e-06	2	40	2	3794341
Pubmed	Complement and c4 null alleles in severe chronic adult periodontitis.	C4A C4B	1.29e-06	2	40	2	17257223
Pubmed	Three extra copies of a C4-related gene in H-2w7 mice are C4/Slp hybrid genes generated by multiple recombinational events.	C4A C4B	1.29e-06	2	40	2	2272665
Pubmed	Multiple C4/Slp genes distinguished by expression after transfection.	C4A C4B	1.29e-06	2	40	2	3023818
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	1.29e-06	2	40	2	7545960
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	1.29e-06	2	40	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	1.29e-06	2	40	2	2572548
Pubmed	Fine-tuned characterization of RCCX copy number variants and their relationship with extended MHC haplotypes.	C4A C4B	1.29e-06	2	40	2	22785613
Pubmed	The complement component C4 of mammals.	C4A C4B	1.29e-06	2	40	2	2302180
Pubmed	Complete cDNA sequence of the fourth component of murine complement.	C4A C4B	1.29e-06	2	40	2	3862104
Pubmed	The BS variant of C4 protects against age-related loss of white matter microstructural integrity.	C4A C4B	1.29e-06	2	40	2	34358307
Pubmed	Association between complement 4 copy number variation and systemic lupus erythematosus: a meta-analysis.	C4A C4B	1.29e-06	2	40	2	32691186
Pubmed	Genetic deficiency in complement component 4b does not alter radiation-induced lung disease in mice.	C4A C4B	1.29e-06	2	40	2	23259761
Pubmed	Acute renal allograft rejection: diagnostic significance of focal peritubular capillary C4d.	C4A C4B	1.29e-06	2	40	2	18360261
Pubmed	Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.	C4A C4B	1.29e-06	2	40	2	22151770
Pubmed	C4d-positive chronic rejection: a frequent entity with a poor outcome.	C4A C4B	1.29e-06	2	40	2	18091514
Pubmed	Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.	C4A C4B	1.29e-06	2	40	2	29080553
Pubmed	Lack of evidence of a specific role for C4A gene deficiency in determining disease susceptibility among C4-deficient patients with systemic lupus erythematosus (SLE).	C4A C4B	1.29e-06	2	40	2	11168010
Pubmed	The androgen-dependent C4-Slp gene is driven by a constitutively competent promoter.	C4A C4B	1.29e-06	2	40	2	8390682
Pubmed	Schizophrenia risk from complex variation of complement component 4.	C4A C4B	1.29e-06	2	40	2	26814963
Pubmed	Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.	C4A C4B	1.29e-06	2	40	2	6589636
Pubmed	Structure and expression of murine fourth complement component (C4) and sex-limited protein (Slp).	C4A C4B	1.29e-06	2	40	2	3902619
Pubmed	Genetic polymorphism of murine C3 controlled by a single co-dominant locus on chromosome 17.	C4A C4B	3.87e-06	3	40	2	681746
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	7.68e-05	9	27	2	1234
GeneFamily	PHD finger proteins	KDM2B KMT2C PHF14	3.20e-04	90	27	3	88
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	KMT2C SMYD1	1.17e-03	34	27	2	487
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	1.31e-03	36	27	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	1.38e-03	37	27	2	454
GeneFamily	AAA ATPases\|Mitochondrial respiratory chain complex assembly factors	NDUFAF1 NDUFAF3	1.62e-03	40	27	2	645
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	DOCK10 PLEKHA1	3.76e-02	206	27	2	682
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 VWA3A DOCK10 HPGDS	1.31e-05	161	40	4	c54010d88f1ecb6e0235bb66084876a4d5bf1ecd
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 DOCK10 HPGDS NDUFAF3	1.62e-05	170	40	4	be2a34c70665d8d11332b1a70eda03d77cb7f7dd
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 DOCK10 GRIK4 HPGDS	1.69e-05	172	40	4	3a37569a5902f3c65ff8d3912421309a8c82ee9b
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FMNL3 DOCK10 GRIK4 HPGDS	1.69e-05	172	40	4	cc9d9dae290f11f8c348c78228af4e49469dc93b
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	VWA3A GRIK4 PLD5 GPC6	2.07e-05	181	40	4	9ede19228ba5c0668a9c06c915510b95585216ef
ToppCell	Bronchial-10x5prime-Immune_Myeloid-Dendritic_cell-DC_activated\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	DOCK10 KDM2B VPS8 TTYH2	3.05e-05	200	40	4	a4c41509ca936e137230a6ae548c90f18a566d12
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Mesenchymal-Unfolded_protein_responsible_cell\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	MOK KDM2B MBD5 TTYH2	3.05e-05	200	40	4	6b7314c425f6b40f1301dd39cc02b0436e96a2ec
Drug	Homocysteine	KDM2B PLEKHA1 SETX NOS2 DDC ANXA10	1.10e-06	195	40	6	ctd:D006710
Drug	2-aminothiophenol	C4A C4B	9.02e-06	3	40	2	ctd:C005464
Drug	xanthoxyletin	NOS2 CALU	1.80e-05	4	40	2	CID000066548
Drug	robustaflavone	NOS2 CALU	1.80e-05	4	40	2	CID005281694
Drug	C070379	MOK C4A HSF1 NOS2 CALU	2.49e-05	199	40	5	CID003034747
Drug	ChAG	C4A SERPINB4	3.00e-05	5	40	2	CID000126253
Drug	Co K	MOK C4A	4.49e-05	6	40	2	CID006852202
Disease	Mitochondrial Diseases	NDUFAF1 NOS2 NDUFAF3	4.07e-05	49	40	3	C0751651
Disease	autism spectrum disorder (is_implicated_in)	CYFIP1 MBD5	2.12e-04	16	40	2	DOID:0060041 (is_implicated_in)
Disease	hepatocellular carcinoma (biomarker_via_orthology)	CARM1 CAD NOS2	4.27e-04	108	40	3	DOID:684 (biomarker_via_orthology)
Disease	Intrahepatic Cholangiocarcinoma	KMT2C NOS2	4.85e-04	24	40	2	C0345905
Disease	Extrahepatic Cholangiocarcinoma	KMT2C NOS2	4.85e-04	24	40	2	C3805278
Disease	Cholangiocarcinoma	KMT2C NOS2	5.70e-04	26	40	2	C0206698
Disease	MITOCHONDRIAL COMPLEX I DEFICIENCY	NDUFAF1 NDUFAF3	7.61e-04	30	40	2	C1838979
Disease	Parkinson's disease (biomarker_via_orthology)	HSF1 DDC	7.61e-04	30	40	2	DOID:14330 (biomarker_via_orthology)
Disease	Complement deficiency disease	C4A C4B	9.21e-04	33	40	2	C0272242
Disease	Parkinson's disease (implicated_via_orthology)	HSF1 DDC VPS13A	1.26e-03	157	40	3	DOID:14330 (implicated_via_orthology)
Disease	Graves' disease (is_implicated_in)	C4A C4B	1.29e-03	39	40	2	DOID:12361 (is_implicated_in)
Disease	systemic lupus erythematosus (implicated_via_orthology)	C4A C4B	1.56e-03	43	40	2	DOID:9074 (implicated_via_orthology)
Disease	left ventricular diastolic function measurement	FMNL3 PHF14	2.45e-03	54	40	2	EFO_0008204

Protein segments in the cluster

Peptide	Gene	Start	Entry
MTQNERYKAAMRRAF	ACOX2	71	Q99424
QRMMIAEAYQSMYGR	ANXA10	51	Q9UJ72
YYMILSRGQIVFMNR	C4B	506	P0C0L5
GFNYKQMMVRDERRF	CALU	146	O43852
FRRRGKEMVDYMANY	DDC	6	P20711
SYGRISIMQFFNYVM	PPP2R3C	151	Q969Q6
ESFMKYMQNEYRSRG	NOS2	441	P35228
KLMNFMYFQRNAIER	CYFIP1	121	Q7L576
KGNRMDYYNALNLYM	FBXO21	276	O94952
LYESQNRGVYMFRMD	KMT2C	4816	Q8NEZ4
KANPVNRYMYVMDTR	MTMR6	226	Q9Y217
MPNYKLTYFNMRGRA	HPGDS	1	O60760
NMMQDYVRTGTYQRA	CARM1	161	Q86X55
MASFVRQLNMYGFRK	HSF1	66	Q00613
MQSLRDGNYYACKQM	MOK	21	Q9UQ07
TADFVNYYFERNMRM	PHF14	616	O94880
NDMFVRTYGMLYMQN	GPC6	121	Q9Y625
RTYGMLYMQNSEVFQ	GPC6	126	Q9Y625
QKGTEMSMSQFVRYY	KDM2B	146	Q8NHM5
FMDRGYVFKMVNNYI	DOCK10	1066	Q96BY6
LRAIMNYQYGFNLVM	FMNL3	231	Q8IVF7
QRTNQMYSYFMFTRG	NDUFAF1	231	Q9Y375
EENFRYNNYKRTMMS	MBD5	1261	Q9P267
MTFFQNSRYQTYQRM	GRIK4	676	Q16099
YYMILSRGQIVFMNR	C4A	506	P0C0L4
VTYMNMTAYNKGRLQ	PLD5	206	Q8N7P1
FRQNEFMYYKMREAA	SMYD1	451	Q8NB12
FMYYKMREAALNNQP	SMYD1	456	Q8NB12
QEYGYDQSMMARFCR	SETX	2221	Q7Z333
AMIYVYNRGMNEFIS	VPS8	681	Q8N3P4
YNMGFLFAYSMRQKT	CDK5RAP1	466	Q96SZ6
RKMFCQYDSRGMSFN	ZNF33B	136	Q06732
MLQVMENGRFAKYKY	VPS13A	3061	Q96RL7
QAMYIDSYNSRGFMI	NDUFAF3	56	Q9BU61
YMNQAMLFGRNPRYE	TTYH2	481	Q9BSA4
DNMVSYYHFQRMNKA	SULT1C4	141	O75897
KNAFDYFNNMRMKYN	WDR44	541	Q5JSH3
YFNNMRMKYNTEGRV	WDR44	546	Q5JSH3
TYKSVQMMRQYNSFN	SERPINB4	206	P48594
AAYFRQAENGMYIRM	CAD	2201	P27708
FVMNAGMRKYFLQAN	PLEKHA1	81	Q9HB21
KYVQMMGGRVYRDLN	TOPBP1	126	Q92547
YKYQQQLSRAMRMYE	VWA3A	476	A6NCI4
MGMYKIILNQTARYF	LEG1	61	Q6P5S2