Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of cytoskeleton	KRT9 ACTN4 TUBG2 TUBG1	5.35e-05	130	32	4	GO:0005200
GeneOntologyMolecularFunction	histone binding	MSH6 INO80 BRD2 SRCAP RNF20	5.95e-05	265	32	5	GO:0042393
GeneOntologyMolecularFunction	actin binding	ACTN4 CORO2B INO80 DST MYO18B PLEKHG3	9.85e-05	479	32	6	GO:0003779
GeneOntologyMolecularFunction	RNA cap binding	LARP1 LARP1B	5.13e-04	21	32	2	GO:0000339
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	MSH6 INO80 SRCAP	1.09e-03	127	32	3	GO:0008094
GeneOntologyMolecularFunction	ATP-dependent chromatin remodeler activity	INO80 SRCAP	1.60e-03	37	32	2	GO:0140658
GeneOntologyMolecularFunction	ATP-dependent protein folding chaperone	HSPA6 HSPA7	1.87e-03	40	32	2	GO:0140662
GeneOntologyMolecularFunction	heat shock protein binding	AHR HSPA6 HSPA7	2.23e-03	163	32	3	GO:0031072
GeneOntologyMolecularFunction	integrin binding	ACTN4 DST JAM2	2.72e-03	175	32	3	GO:0005178
GeneOntologyMolecularFunction	ATP-dependent activity	MSH6 INO80 SRCAP HSPA6 HSPA7	2.74e-03	614	32	5	GO:0140657
GeneOntologyCellularComponent	mitotic spindle microtubule	HAUS1 TUBG1	2.04e-04	14	32	2	GO:1990498
GeneOntologyCellularComponent	spindle microtubule	HAUS1 TUBG2 TUBG1	3.06e-04	86	32	3	GO:0005876
GeneOntologyCellularComponent	supramolecular fiber	KRT9 ACTN4 INO80 DST MYO18B HAUS1 TUBG2 TUBG1	3.12e-04	1179	32	8	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KRT9 ACTN4 INO80 DST MYO18B HAUS1 TUBG2 TUBG1	3.27e-04	1187	32	8	GO:0099081
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KRT9 INO80 DST MYO18B HAUS1 TUBG2 TUBG1	3.48e-04	899	32	7	GO:0099513
GeneOntologyCellularComponent	gamma-tubulin complex	TUBG2 TUBG1	4.68e-04	21	32	2	GO:0000930
GeneOntologyCellularComponent	contractile actin filament bundle	ACTN4 CORO2B DST	5.80e-04	107	32	3	GO:0097517
GeneOntologyCellularComponent	stress fiber	ACTN4 CORO2B DST	5.80e-04	107	32	3	GO:0001725
GeneOntologyCellularComponent	spindle	INO80 HAUS1 TUBG2 TUBG1 CNTRL	6.93e-04	471	32	5	GO:0005819
GeneOntologyCellularComponent	actomyosin	ACTN4 CORO2B DST	7.53e-04	117	32	3	GO:0042641
GeneOntologyCellularComponent	actin filament bundle	ACTN4 CORO2B DST	7.72e-04	118	32	3	GO:0032432
GeneOntologyCellularComponent	INO80-type complex	INO80 SRCAP	8.37e-04	28	32	2	GO:0097346
GeneOntologyCellularComponent	pericentriolar material	TUBG2 TUBG1	8.37e-04	28	32	2	GO:0000242
GeneOntologyCellularComponent	microtubule	INO80 DST HAUS1 TUBG2 TUBG1	1.20e-03	533	32	5	GO:0005874
GeneOntologyCellularComponent	COP9 signalosome	HSPA6 HSPA7	1.54e-03	38	32	2	GO:0008180
GeneOntologyCellularComponent	Z disc	ACTN4 DST MYO18B	1.57e-03	151	32	3	GO:0030018
GeneOntologyCellularComponent	I band	ACTN4 DST MYO18B	2.06e-03	166	32	3	GO:0031674
GeneOntologyCellularComponent	perinuclear region of cytoplasm	RAPGEF1 KRT9 ACTN4 DST SRCAP CNTRL	2.62e-03	934	32	6	GO:0048471
GeneOntologyCellularComponent	mitotic spindle	HAUS1 TUBG1 CNTRL	3.54e-03	201	32	3	GO:0072686
GeneOntologyCellularComponent	spindle pole	HAUS1 TUBG1 CNTRL	3.74e-03	205	32	3	GO:0000922
GeneOntologyCellularComponent	focal adhesion	ACTN4 CORO2B PTPRA DST	4.06e-03	431	32	4	GO:0005925
GeneOntologyCellularComponent	nuclear protein-containing complex	AHR MSH6 INO80 SRCAP CDK12 HSPA6 HSPA7	4.15e-03	1377	32	7	GO:0140513
GeneOntologyCellularComponent	cell-substrate junction	ACTN4 CORO2B PTPRA DST	4.47e-03	443	32	4	GO:0030055
GeneOntologyCellularComponent	sarcomere	ACTN4 DST MYO18B	6.42e-03	249	32	3	GO:0030017
GeneOntologyCellularComponent	nuclear chromosome	INO80 SRCAP TUBG1	6.78e-03	254	32	3	GO:0000228
GeneOntologyCellularComponent	myofibril	ACTN4 DST MYO18B	8.26e-03	273	32	3	GO:0030016
GeneOntologyCellularComponent	cell-cell contact zone	DST JAM2	9.09e-03	94	32	2	GO:0044291
GeneOntologyCellularComponent	SWI/SNF superfamily-type complex	INO80 SRCAP	9.46e-03	96	32	2	GO:0070603
GeneOntologyCellularComponent	cytoplasmic stress granule	LARP1 LARP1B	9.46e-03	96	32	2	GO:0010494
GeneOntologyCellularComponent	contractile muscle fiber	ACTN4 DST MYO18B	9.74e-03	290	32	3	GO:0043292
GeneOntologyCellularComponent	actin cytoskeleton	ACTN4 CORO2B DST MYO18B	1.11e-02	576	32	4	GO:0015629
GeneOntologyCellularComponent	microtubule organizing center	HAUS1 TUBG2 HSPA6 TUBG1 CNTRL	1.22e-02	919	32	5	GO:0005815
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	RPGRIP1 DST CNTRL	1.24e-02	317	32	3	GO:0032838
MousePheno	abnormal cell adhesion	RAPGEF1 ACTN4 CORO2B PTPRA	6.36e-06	69	25	4	MP:0003566
MousePheno	absent superior cervical ganglion	ACTN4 BRD2	1.10e-04	9	25	2	MP:0001014
MousePheno	double outlet right ventricle	ACTN4 BRD2 ADAMTS6 CNTRL	1.35e-04	150	25	4	MP:0000284
MousePheno	abnormal ductus venosus morphology	AHR ACTN4 BRD2	1.46e-04	58	25	3	MP:0013873
MousePheno	abnormal vein morphology	AHR ACTN4 MYO18B BRD2	2.50e-04	176	25	4	MP:0002725
MousePheno	muscular ventricular septal defect	ACTN4 BRD2 ADAMTS6	3.39e-04	77	25	3	MP:0010420
MousePheno	abnormal liver sinusoid morphology	AHR ACTN4 BRD2	3.65e-04	79	25	3	MP:0008989
MousePheno	abnormal interventricular septum muscular part morphology	ACTN4 BRD2 ADAMTS6	3.65e-04	79	25	3	MP:0010498
MousePheno	abnormal heart and great artery attachment	ACTN4 BRD2 ADAMTS6 CNTRL	4.46e-04	205	25	4	MP:0010426
MousePheno	abnormal heart and great vessel attachment	ACTN4 BRD2 ADAMTS6 CNTRL	4.71e-04	208	25	4	MP:0010425
MousePheno	perimembraneous ventricular septal defect	ACTN4 BRD2 ADAMTS6	5.71e-04	92	25	3	MP:0010418
MousePheno	increased organ/body region tumor incidence	AHR MSH6 KRT9 ACTN4 RNF20	5.85e-04	395	25	5	MP:0010274
MousePheno	abnormal interventricular septum membranous part morphology	ACTN4 BRD2 ADAMTS6	5.90e-04	93	25	3	MP:0008823
MousePheno	abnormal organ/body region tumor incidence	AHR MSH6 KRT9 ACTN4 RNF20	6.26e-04	401	25	5	MP:0013152
MousePheno	abnormal cranial blood vasculature morphology	RAPGEF1 ACTN4 BRD2	6.27e-04	95	25	3	MP:0014012
MousePheno	abnormal blood vessel morphology	AHR RAPGEF1 ACTN4 DST COLGALT1 MYO18B BRD2 ADAMTS6 CNTRL	6.62e-04	1472	25	9	MP:0001614
MousePheno	abnormal liver lobule morphology	AHR ACTN4 COLGALT1 BRD2	6.77e-04	229	25	4	MP:0008987
MousePheno	abnormal heart size	AHR LARP1 ACTN4 BRD2 ADAMTS6 CDK12 CNTRL JAM2	7.39e-04	1180	25	8	MP:0005406
MousePheno	heterochrony	ACTN4 BRD2	7.59e-04	23	25	2	MP:0014021
MousePheno	blistering	KRT9 DST	8.27e-04	24	25	2	MP:0001208
MousePheno	abnormal embryonic neuroepithelium morphology	RAPGEF1 COLGALT1 BRD2	8.40e-04	105	25	3	MP:0004261
MousePheno	abnormal liver parenchyma morphology	AHR ACTN4 COLGALT1 BRD2	8.45e-04	243	25	4	MP:0008986
MousePheno	enlarged heart	AHR LARP1 ACTN4 BRD2 ADAMTS6 CDK12 JAM2	8.57e-04	916	25	7	MP:0000274
MousePheno	abnormal liver vasculature morphology	AHR ACTN4 BRD2	9.11e-04	108	25	3	MP:0009820
Domain	DM15	LARP1 LARP1B	2.84e-06	2	32	2	SM00684
Domain	DM15	LARP1 LARP1B	2.84e-06	2	32	2	IPR006607
Domain	Gamma_tubulin	TUBG2 TUBG1	2.84e-06	2	32	2	IPR002454
Domain	La	LARP1 LARP1B	5.94e-05	7	32	2	PF05383
Domain	Lupus_La_RNA-bd	LARP1 LARP1B	5.94e-05	7	32	2	IPR006630
Domain	LA	LARP1 LARP1B	5.94e-05	7	32	2	SM00715
Domain	HTH_LA	LARP1 LARP1B	5.94e-05	7	32	2	PS50961
Domain	HSP70	HSPA6 HSPA7	3.36e-04	16	32	2	PF00012
Domain	HSP70_2	HSPA6 HSPA7	3.81e-04	17	32	2	PS00329
Domain	HSP70_3	HSPA6 HSPA7	3.81e-04	17	32	2	PS01036
Domain	HSP70_1	HSPA6 HSPA7	3.81e-04	17	32	2	PS00297
Domain	Hsp_70_fam	HSPA6 HSPA7	4.28e-04	18	32	2	IPR013126
Domain	-	TUBG2 TUBG1	5.30e-04	20	32	2	3.30.1330.20
Domain	-	TUBG2 TUBG1	5.85e-04	21	32	2	1.10.287.600
Domain	Tubulin/FtsZ_2-layer-sand-dom	TUBG2 TUBG1	6.43e-04	22	32	2	IPR018316
Domain	Tubulin_C	TUBG2 TUBG1	6.43e-04	22	32	2	SM00865
Domain	-	TUBG2 TUBG1	6.43e-04	22	32	2	3.40.50.1440
Domain	Tubulin_C	TUBG2 TUBG1	6.43e-04	22	32	2	PF03953
Domain	Tubulin_C	TUBG2 TUBG1	7.04e-04	23	32	2	IPR023123
Domain	Actinin_actin-bd_CS	ACTN4 DST	7.04e-04	23	32	2	IPR001589
Domain	TUBULIN	TUBG2 TUBG1	7.04e-04	23	32	2	PS00227
Domain	Tubulin	TUBG2 TUBG1	7.04e-04	23	32	2	IPR000217
Domain	Tub_FtsZ_C	TUBG2 TUBG1	7.04e-04	23	32	2	IPR008280
Domain	Tubulin	TUBG2 TUBG1	7.04e-04	23	32	2	SM00864
Domain	ACTININ_2	ACTN4 DST	7.04e-04	23	32	2	PS00020
Domain	Tubulin_CS	TUBG2 TUBG1	7.04e-04	23	32	2	IPR017975
Domain	ACTININ_1	ACTN4 DST	7.04e-04	23	32	2	PS00019
Domain	Spectrin	ACTN4 DST	7.04e-04	23	32	2	PF00435
Domain	Tubulin_FtsZ_GTPase	TUBG2 TUBG1	7.67e-04	24	32	2	IPR003008
Domain	Tubulin	TUBG2 TUBG1	7.67e-04	24	32	2	PF00091
Domain	Spectrin_repeat	ACTN4 DST	1.12e-03	29	32	2	IPR002017
Domain	SNF2_N	INO80 SRCAP	1.37e-03	32	32	2	PF00176
Domain	SNF2_N	INO80 SRCAP	1.37e-03	32	32	2	IPR000330
Domain	Spectrin/alpha-actinin	ACTN4 DST	1.37e-03	32	32	2	IPR018159
Domain	SPEC	ACTN4 DST	1.37e-03	32	32	2	SM00150
Domain	EF-hand_1	CAPNS2 ACTN4 DST	2.20e-03	152	32	3	PF00036
Domain	EF_HAND_1	CAPNS2 ACTN4 DST	5.04e-03	204	32	3	PS00018
Domain	CH	ACTN4 DST	5.53e-03	65	32	2	SM00033
Domain	CH	ACTN4 DST	6.39e-03	70	32	2	PF00307
Domain	-	ACTN4 DST	6.57e-03	71	32	2	1.10.418.10
Domain	CH	ACTN4 DST	6.93e-03	73	32	2	PS50021
Domain	EF_HAND_2	CAPNS2 ACTN4 DST	7.11e-03	231	32	3	PS50222
Domain	EF_hand_dom	CAPNS2 ACTN4 DST	7.20e-03	232	32	3	IPR002048
Domain	CH-domain	ACTN4 DST	7.30e-03	75	32	2	IPR001715
Domain	-	CAPNS2 ACTN4 DST	9.92e-03	261	32	3	1.10.238.10
Pathway	REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES	HAUS1 TUBG2 TUBG1 CNTRL	1.37e-05	81	26	4	M748
Pathway	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	HAUS1 TUBG2 TUBG1 CNTRL	2.58e-05	95	26	4	M6729
Pathway	REACTOME_MITOTIC_PROMETAPHASE	CENPP HAUS1 TUBG2 TUBG1 CNTRL	3.10e-05	204	26	5	M4217
Pathway	REACTOME_AURKA_ACTIVATION_BY_TPX2	HAUS1 TUBG1 CNTRL	3.05e-04	72	26	3	M27749
Pathway	REACTOME_MITOTIC_G2_G2_M_PHASES	HAUS1 TUBG2 TUBG1 CNTRL	4.60e-04	200	26	4	M864
Pathway	REACTOME_MITOTIC_PROMETAPHASE	CENPP HAUS1 TUBG2 TUBG1	4.78e-04	202	26	4	MM15362
Pathway	REACTOME_REGULATION_OF_PLK1_ACTIVITY_AT_G2_M_TRANSITION	HAUS1 TUBG1 CNTRL	5.33e-04	87	26	3	M27194
Pathway	REACTOME_RECRUITMENT_OF_NUMA_TO_MITOTIC_CENTROSOMES	HAUS1 TUBG2 TUBG1	5.88e-04	90	26	3	MM14979
Pathway	REACTOME_ANCHORING_OF_THE_BASAL_BODY_TO_THE_PLASMA_MEMBRANE	HAUS1 TUBG1 CNTRL	7.32e-04	97	26	3	M27478
Pathway	REACTOME_M_PHASE	CENPP HAUS1 TUBG2 TUBG1 CNTRL	8.70e-04	417	26	5	M27662
Pathway	PID_INTEGRIN_A4B1_PATHWAY	PTPRA JAM2	1.67e-03	33	26	2	M277
Pathway	BIOCARTA_INTEGRIN_PATHWAY	CAPNS2 RAPGEF1	1.77e-03	34	26	2	M3342
Pathway	WP_ALSTROM_SYNDROME	ACTN4 TUBG1	1.77e-03	34	26	2	M45524
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	CAPNS2 DST COLGALT1 JAM2	2.08e-03	300	26	4	M610
Pubmed	Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.	LARP1 MSH6 KRT9 ACTN4 IRS4 DST SRCAP CNTRL RNF20	3.24e-08	807	32	9	30575818
Pubmed	A unique set of centrosome proteins requires pericentrin for spindle-pole localization and spindle orientation.	TUBG2 TUBG1 CNTRL	8.45e-08	10	32	3	25220058
Pubmed	Retinal degeneration and failure of photoreceptor outer segment formation in mice with targeted deletion of the Joubert syndrome gene, Ahi1.	RPGRIP1 TUBG2 TUBG1	8.45e-08	10	32	3	20592197
Pubmed	Charting the molecular network of the drug target Bcr-Abl.	RAPGEF1 KRT9 ACTN4 PTPRA HSPA6 HSPA7	1.45e-07	266	32	6	19380743
Pubmed	Nuclear actin interactome analysis links actin to KAT14 histone acetyl transferase and mRNA splicing.	MSH6 ACTN4 IRS4 DST SRCAP CDK12 RNF20	3.25e-07	506	32	7	30890647
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MSH6 KRT9 INO80 DST BRD2 SRCAP CDK12 HSPA6 TUBG1	3.89e-07	1082	32	9	38697112
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	LARP1 MSH6 KRT9 ACTN4 IRS4 DST CDK12 HSPA6 TUBG1	6.42e-07	1149	32	9	35446349
Pubmed	The human heat-shock genes HSPA6 and HSPA7 are both expressed and localize to chromosome 1.	HSPA6 HSPA7	8.20e-07	2	32	2	1346391
Pubmed	Differential expression of human γ-tubulin isotypes during neuronal development and oxidative stress points to a γ-tubulin-2 prosurvival function.	TUBG2 TUBG1	8.20e-07	2	32	2	28119396
Pubmed	Overexpression of γ-tubulin in non-small cell lung cancer.	TUBG2 TUBG1	8.20e-07	2	32	2	22806905
Pubmed	Gene knockout analysis of two gamma-tubulin isoforms in mice.	TUBG2 TUBG1	8.20e-07	2	32	2	15893303
Pubmed	Allocation of gamma-tubulin between oocyte cortex and meiotic spindle influences asymmetric cytokinesis in the mouse oocyte.	TUBG2 TUBG1	8.20e-07	2	32	2	17287496
Pubmed	Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes.	INO80 SRCAP	8.20e-07	2	32	2	17101442
Pubmed	MTOC reorientation occurs during FcgammaR-mediated phagocytosis in macrophages.	TUBG2 TUBG1	8.20e-07	2	32	2	17442887
Pubmed	The gamma-tubulin gene family in humans.	TUBG2 TUBG1	2.46e-06	3	32	2	10903841
Pubmed	Characterization of the human homologue of the yeast spc98p and its association with gamma-tubulin.	TUBG2 TUBG1	2.46e-06	3	32	2	9566969
Pubmed	The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.	TUBG2 TUBG1	2.46e-06	3	32	2	26021315
Pubmed	Human TUBG2 gene is expressed as two splice variant mRNA and involved in cell growth.	TUBG2 TUBG1	2.46e-06	3	32	2	27015882
Pubmed	Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.	LARP1 MSH6 IRS4 BRD2 HSPA6 RNF20	2.75e-06	441	32	6	31239290
Pubmed	UBR-box containing protein, UBR5, is over-expressed in human lung adenocarcinoma and is a potential therapeutic target.	MSH6 IRS4 TUBG1	2.82e-06	30	32	3	32867711
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	MSH6 ACTN4 IRS4 PTPRA COLGALT1 BRD2 HAUS1 HSPA6	3.68e-06	1049	32	8	27880917
Pubmed	Proteomic analysis reveals novel binding partners of MIP-T3 in human cells.	KRT9 ACTN4 HSPA6	4.15e-06	34	32	3	20391533
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	LARP1 RPGRIP1 ACTN4 IRS4 DST BRD2 SRCAP HSPA6 CNTRL	4.17e-06	1442	32	9	35575683
Pubmed	PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.	LARP1 MSH6 ACTN4 IRS4 DST HSPA6	4.32e-06	477	32	6	31300519
Pubmed	Loss of Necdin impairs myosin activation and delays cell polarization.	TUBG2 TUBG1	4.92e-06	4	32	2	20665884
Pubmed	Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells.	TUBG2 TUBG1	4.92e-06	4	32	2	16798874
Pubmed	Cilia organize ependymal planar polarity.	TUBG2 TUBG1	4.92e-06	4	32	2	20164345
Pubmed	Piezo mechanosensory channels regulate centrosome integrity and mitotic entry.	TUBG2 TUBG1	4.92e-06	4	32	2	36574677
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	MSH6 CDK12 HSPA7 CNTRL RNF20	5.99e-06	285	32	5	32838362
Pubmed	Primary cilia dynamics instruct tissue patterning and repair of corneal endothelium.	TUBG2 TUBG1	8.19e-06	5	32	2	21285373
Pubmed	Analysis of Ellis van Creveld syndrome gene products: implications for cardiovascular development and disease.	TUBG2 TUBG1	8.19e-06	5	32	2	19251731
Pubmed	The essential role of centrosomal NDE1 in human cerebral cortex neurogenesis.	TUBG2 TUBG1	8.19e-06	5	32	2	21529752
Pubmed	Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis.	TUBG2 TUBG1	8.19e-06	5	32	2	18729223
Pubmed	Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.	TUBG2 TUBG1	8.19e-06	5	32	2	29244804
Pubmed	Mutations in the Heterotopia Gene Eml1/EML1 Severely Disrupt the Formation of Primary Cilia.	TUBG2 TUBG1	8.19e-06	5	32	2	31390572
Pubmed	WDR62 is associated with the spindle pole and is mutated in human microcephaly.	TUBG2 TUBG1	8.19e-06	5	32	2	20890279
Pubmed	Speriolin is a novel human and mouse sperm centrosome protein.	TUBG2 TUBG1	8.19e-06	5	32	2	20542897
Pubmed	A two-kinesin mechanism controls neurogenesis in the developing brain.	TUBG2 TUBG1	8.19e-06	5	32	2	38040957
Pubmed	Regulation of microtubule formation in activated mast cells by complexes of gamma-tubulin with Fyn and Syk kinases.	TUBG2 TUBG1	8.19e-06	5	32	2	16751367
Pubmed	A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos.	TUBG2 TUBG1	8.19e-06	5	32	2	15680357
Pubmed	Novel Jbts17 mutant mouse model of Joubert syndrome with cilia transition zone defects and cerebellar and other ciliopathy related anomalies.	TUBG2 TUBG1	8.19e-06	5	32	2	25877302
Pubmed	HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure, and centrosomes.	TUBG2 TUBG1	8.19e-06	5	32	2	14767062
Pubmed	Molecular mechanisms underlying nucleocytoplasmic shuttling of actinin-4.	ACTN4 INO80	8.19e-06	5	32	2	20197409
Pubmed	SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.	LARP1 MSH6 IRS4 SRCAP CDK12 HSPA6	9.62e-06	549	32	6	38280479
Pubmed	Systematic analyses of the ultraviolet radiation resistance-associated gene product (UVRAG) protein interactome by tandem affinity purification.	MSH6 IRS4 PTPRA	1.19e-05	48	32	3	26590968
Pubmed	The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP.	TUBG2 TUBG1	1.23e-05	6	32	2	38546045
Pubmed	Development of Ependymal and Postnatal Neural Stem Cells and Their Origin from a Common Embryonic Progenitor.	TUBG2 TUBG1	1.23e-05	6	32	2	30970247
Pubmed	Paxillin localizes to the lymphocyte microtubule organizing center and associates with the microtubule cytoskeleton.	TUBG2 TUBG1	1.23e-05	6	32	2	10840040
Pubmed	Expression Analyses of Cep152, a Responsible Gene Product for Autosomal Recessive Primary Microcephaly, during Mouse Brain Development.	TUBG2 TUBG1	1.23e-05	6	32	2	35259752
Pubmed	CROCCP2 acts as a human-specific modifier of cilia dynamics and mTOR signaling to promote expansion of cortical progenitors.	TUBG2 TUBG1	1.23e-05	6	32	2	36334595
Pubmed	A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.	TUBG2 TUBG1	1.23e-05	6	32	2	11237715
Pubmed	DOCK7 interacts with TACC3 to regulate interkinetic nuclear migration and cortical neurogenesis.	TUBG2 TUBG1	1.23e-05	6	32	2	22842144
Pubmed	Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis.	TUBG2 TUBG1	1.23e-05	6	32	2	29229864
Pubmed	RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.	LARP1 KRT9 IRS4 HSPA6	1.27e-05	156	32	4	26170170
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	ACTN4 IRS4 COLGALT1 HSPA6	1.62e-05	166	32	4	35687106
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	LARP1 KRT9 ACTN4 IRS4 PTPRA COLGALT1 HSPA6	1.70e-05	922	32	7	27609421
Pubmed	PCP auto count: a novel Fiji/ImageJ plug-in for automated quantification of planar cell polarity and cell counting.	TUBG2 TUBG1	1.72e-05	7	32	2	38827526
Pubmed	Mammalian RanBP1 regulates centrosome cohesion during mitosis.	TUBG2 TUBG1	1.72e-05	7	32	2	12840069
Pubmed	AIRE is a critical spindle-associated protein in embryonic stem cells.	TUBG2 TUBG1	1.72e-05	7	32	2	28742026
Pubmed	HIV-1 Vpr hijacks EDD-DYRK2-DDB1DCAF1 to disrupt centrosome homeostasis.	TUBG2 TUBG1	1.72e-05	7	32	2	29724823
Pubmed	TMEM216 promotes primary ciliogenesis and Hedgehog signaling through the SUFU-GLI2/GLI3 axis.	TUBG2 TUBG1	1.72e-05	7	32	2	38261656
Pubmed	The ciliary protein RPGRIP1L governs autophagy independently of its proteasome-regulating function at the ciliary base in mouse embryonic fibroblasts.	TUBG2 TUBG1	1.72e-05	7	32	2	29372668
Pubmed	A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return.	TUBG2 TUBG1	1.72e-05	7	32	2	30289203
Pubmed	Asymmetric segregation of the double-stranded RNA binding protein Staufen2 during mammalian neural stem cell divisions promotes lineage progression.	TUBG2 TUBG1	1.72e-05	7	32	2	22902295
Pubmed	Pax6 controls centriole maturation in cortical progenitors through Odf2.	TUBG2 TUBG1	1.72e-05	7	32	2	25352170
Pubmed	A ciliopathy complex builds distal appendages to initiate ciliogenesis.	TUBG2 TUBG1	2.29e-05	8	32	2	34241634
Pubmed	A dual role of FGF10 in proliferation and coordinated migration of epithelial leading edge cells during mouse eyelid development.	TUBG2 TUBG1	2.29e-05	8	32	2	15958512
Pubmed	Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function.	TUBG2 TUBG1	2.29e-05	8	32	2	27727273
Pubmed	A role for AGL ubiquitination in the glycogen storage disorders of Lafora and Cori's disease.	TUBG2 TUBG1	2.29e-05	8	32	2	17908927
Pubmed	The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.	TUBG2 TUBG1	2.29e-05	8	32	2	19112494
Pubmed	Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development.	TUBG2 TUBG1	2.29e-05	8	32	2	18239929
Pubmed	Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling.	TUBG2 TUBG1	2.29e-05	8	32	2	26540106
Pubmed	Rack1 regulates cellular patterning and polarity in the mouse cochlea.	TUBG2 TUBG1	2.29e-05	8	32	2	36252648
Pubmed	The AP-2 complex interacts with γ-TuRC and regulates the proliferative capacity of neural progenitors.	TUBG2 TUBG1	2.29e-05	8	32	2	38086550
Pubmed	ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules.	TUBG2 TUBG1	2.29e-05	8	32	2	27562601
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	MSH6 ACTN4 DST COLGALT1 SRCAP PLEKHG3 HSPA6 RNF20	2.35e-05	1353	32	8	29467282
Pubmed	Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.	MSH6 IRS4 RNF20	2.58e-05	62	32	3	26508657
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	MSH6 INO80 COLGALT1 CDK12 TUBG1	2.92e-05	396	32	5	26687479
Pubmed	Ciliary proteins link basal body polarization to planar cell polarity regulation.	TUBG2 TUBG1	2.94e-05	9	32	2	18066062
Pubmed	TRIP6 functions in brain ciliogenesis.	TUBG2 TUBG1	2.94e-05	9	32	2	34620853
Pubmed	Centriolar Protein C2cd3 Is Required for Craniofacial Development.	TUBG2 TUBG1	2.94e-05	9	32	2	34211969
Pubmed	Direct binding of NuMA to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules.	TUBG2 TUBG1	2.94e-05	9	32	2	11956313
Pubmed	Functional analysis of bacterial artificial chromosomes in mammalian cells: mouse Cdc6 is associated with the mitotic spindle apparatus.	TUBG2 TUBG1	2.94e-05	9	32	2	14667810
Pubmed	Autonomous and non-cell autonomous role of cilia in structural birth defects in mice.	TUBG2 TUBG1	2.94e-05	9	32	2	38079449
Pubmed	Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis.	TUBG2 TUBG1	2.94e-05	9	32	2	8838651
Pubmed	Spinocerebellar ataxia type 11-associated alleles of Ttbk2 dominantly interfere with ciliogenesis and cilium stability.	TUBG2 TUBG1	2.94e-05	9	32	2	30532139
Pubmed	TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.	TUBG2 TUBG1	2.94e-05	9	32	2	31086189
Pubmed	MITOPLD is a mitochondrial protein essential for nuage formation and piRNA biogenesis in the mouse germline.	TUBG2 TUBG1	2.94e-05	9	32	2	21397847
Pubmed	Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.	TUBG2 TUBG1	2.94e-05	9	32	2	30824354
Pubmed	Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring gamma-tubulin ring complex.	TUBG2 TUBG1 CNTRL	3.11e-05	66	32	3	12221128
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	LARP1 KRT9 IRS4 LARP1B CDK12 HSPA6	3.16e-05	678	32	6	30209976
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	LARP1 MSH6 KRT9 ACTN4 COLGALT1 HSPA6 TUBG1 RNF20	3.23e-05	1415	32	8	28515276
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	LARP1 MSH6 IRS4 DST COLGALT1 PLEKHG3 HSPA6 TUBG1	3.66e-05	1440	32	8	30833792
Pubmed	GemC1 controls multiciliogenesis in the airway epithelium.	TUBG2 TUBG1	3.67e-05	10	32	2	26882546
Pubmed	A role for primary cilia in aortic valve development and disease.	TUBG2 TUBG1	3.67e-05	10	32	2	28556366
Pubmed	Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain.	TUBG2 TUBG1	3.67e-05	10	32	2	26748089
Pubmed	Mammalian neurogenesis requires Treacle-Plk1 for precise control of spindle orientation, mitotic progression, and maintenance of neural progenitor cells.	TUBG2 TUBG1	3.67e-05	10	32	2	22479190
Pubmed	DZIP1 regulates mammalian cardiac valve development through a Cby1-β-catenin mechanism.	TUBG2 TUBG1	4.49e-05	11	32	2	33811421
Pubmed	Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome.	TUBG2 TUBG1	4.49e-05	11	32	2	19279158
Pubmed	Eml1 loss impairs apical progenitor spindle length and soma shape in the developing cerebral cortex.	TUBG2 TUBG1	4.49e-05	11	32	2	29229923
Interaction	ACTB interactions	ACTN4 INO80 DST LARP1B COLGALT1 MYO18B SRCAP HAUS1 PLEKHG3 TUBG1	4.20e-06	1083	32	10	int:ACTB
Interaction	AGR2 interactions	LARP1 MSH6 KRT9 ACTN4 IRS4 DST SRCAP CNTRL RNF20	1.01e-05	934	32	9	int:AGR2
Interaction	RPS3 interactions	LARP1 ACTN4 DST LARP1B HAUS1 CDK12 TUBG1 RNF20	1.27e-05	721	32	8	int:RPS3
Interaction	ARMC5 interactions	ACTN4 IRS4 COLGALT1 HSPA6 TUBG1	1.52e-05	201	32	5	int:ARMC5
Interaction	TRAF3IP1 interactions	KRT9 ACTN4 DST HSPA6	1.57e-05	96	32	4	int:TRAF3IP1
Interaction	BAP1 interactions	LARP1 MSH6 KRT9 ACTN4 IRS4 INO80 DST CDK12 HSPA6 TUBG1	2.30e-05	1314	32	10	int:BAP1
Interaction	NPHP4 interactions	RPGRIP1 IRS4 CDK12 HSPA6 CNTRL	3.28e-05	236	32	5	int:NPHP4
Interaction	YAP1 interactions	LARP1 MSH6 IRS4 BRD2 SRCAP CDK12 HSPA6 HSPA7 CUEDC1	3.60e-05	1095	32	9	int:YAP1
Interaction	HAUS2 interactions	IRS4 HAUS1 TUBG1 CNTRL	4.57e-05	126	32	4	int:HAUS2
Interaction	WWTR1 interactions	LARP1 MSH6 IRS4 SRCAP CDK12 HSPA6	4.65e-05	422	32	6	int:WWTR1
Interaction	PTGER4 interactions	ACTN4 PTPRA DST	5.99e-05	48	32	3	int:PTGER4
Interaction	RNF126 interactions	CENPP MSH6 IRS4 RNF20	6.52e-05	138	32	4	int:RNF126
Interaction	PPP2R1A interactions	LARP1 IRS4 PTPRA COLGALT1 CDK12 HSPA7 CNTRL	6.76e-05	665	32	7	int:PPP2R1A
Interaction	RC3H1 interactions	LARP1 R3HDM2 KRT9 IRS4 LARP1B CDK12 HSPA6	7.57e-05	677	32	7	int:RC3H1
Interaction	PINK1 interactions	CAPNS2 LARP1 MSH6 ACTN4 IRS4 DST HSPA6	7.71e-05	679	32	7	int:PINK1
Interaction	CEP250 interactions	IRS4 DST HAUS1 HSPA7 TUBG1	8.31e-05	287	32	5	int:CEP250
Interaction	CCNI2 interactions	LARP1B HSPA6	8.73e-05	9	32	2	int:CCNI2
Interaction	ACTC1 interactions	MSH6 ACTN4 IRS4 DST SRCAP CDK12 RNF20	8.84e-05	694	32	7	int:ACTC1
Interaction	TFPT interactions	RPGRIP1 INO80 BRD2 HAUS1	1.16e-04	160	32	4	int:TFPT
Interaction	MECP2 interactions	MSH6 KRT9 INO80 DST BRD2 SRCAP CDK12 HSPA6 TUBG1	1.26e-04	1287	32	9	int:MECP2
Interaction	ACTR8 interactions	INO80 BRD2 SRCAP	1.29e-04	62	32	3	int:ACTR8
Interaction	UCHL5 interactions	LARP1 KRT9 ACTN4 INO80 RNF20	1.37e-04	319	32	5	int:UCHL5
Interaction	CDC34 interactions	LARP1 MSH6 IRS4 HSPA6 CUEDC1	1.55e-04	328	32	5	int:CDC34
Interaction	AURKB interactions	LARP1 MSH6 IRS4 PLEKHG3 HSPA7 TUBG1 CNTRL	1.57e-04	761	32	7	int:AURKB
Interaction	SNAI1 interactions	AHR LARP1 MSH6 IRS4 BRD2 RNF20	1.91e-04	546	32	6	int:SNAI1
Interaction	SHC1 interactions	RAPGEF1 KRT9 ACTN4 CORO2B HSPA6	2.46e-04	362	32	5	int:SHC1
Interaction	YWHAH interactions	LARP1 R3HDM2 IRS4 DST LARP1B PLEKHG3 TUBG1 CNTRL	2.53e-04	1102	32	8	int:YWHAH
Interaction	ACE2 interactions	LARP1 MSH6 KRT9 ACTN4 IRS4 BRD2 HSPA6 HSPA7	2.59e-04	1106	32	8	int:ACE2
Interaction	GANAB interactions	LARP1 MSH6 COLGALT1 TUBG1 CNTRL	2.65e-04	368	32	5	int:GANAB
Interaction	NEK4 interactions	RPGRIP1 ACTN4 IRS4 DST ADAMTS6 HSPA6	2.70e-04	582	32	6	int:NEK4
Interaction	LARP7 interactions	LARP1 KRT9 IRS4 LARP1B BRD2 CDK12 HSPA6 HSPA7	2.70e-04	1113	32	8	int:LARP7
Interaction	CRK interactions	RAPGEF1 KRT9 IRS4 PTPRA HSPA6	2.72e-04	370	32	5	int:CRK
Interaction	YWHAQ interactions	LARP1 R3HDM2 KRT9 IRS4 DST LARP1B PLEKHG3 RNF20	2.79e-04	1118	32	8	int:YWHAQ
Interaction	MEX3A interactions	CENPP LARP1 R3HDM2 ACTN4 DST	3.23e-04	384	32	5	int:MEX3A
Interaction	RB1CC1 interactions	LARP1 IRS4 TUBG2 TUBG1 RNF20	3.34e-04	387	32	5	int:RB1CC1
Interaction	TOP3B interactions	RAPGEF1 R3HDM2 ACTN4 INO80 DST BRD2 SRCAP CDK12 TUBG1	3.44e-04	1470	32	9	int:TOP3B
Interaction	INO80 interactions	ACTN4 INO80 BRD2	3.52e-04	87	32	3	int:INO80
Interaction	ARPC1B interactions	ACTN4 CORO2B HSPA7 TUBG1	3.58e-04	215	32	4	int:ARPC1B
Interaction	NUP43 interactions	LARP1 INO80 DST SRCAP CDK12 HSPA6	3.95e-04	625	32	6	int:NUP43
Interaction	SIRT6 interactions	AHR LARP1 MSH6 IRS4 SRCAP RNF20	4.06e-04	628	32	6	int:SIRT6
Interaction	PRKCZ interactions	MSH6 ACTN4 IRS4 HSPA6 HSPA7	4.45e-04	412	32	5	int:PRKCZ
Interaction	TUBGCP3 interactions	IRS4 TUBG2 TUBG1 CNTRL	4.55e-04	229	32	4	int:TUBGCP3
Interaction	IPO5 interactions	LARP1 RPGRIP1 PTPRA COLGALT1 HAUS1	4.55e-04	414	32	5	int:IPO5
Interaction	PIK3R2 interactions	KRT9 IRS4 HAUS1 HSPA6	4.62e-04	230	32	4	int:PIK3R2
Interaction	UVRAG interactions	MSH6 IRS4 PTPRA	4.84e-04	97	32	3	int:UVRAG
Interaction	LIMA1 interactions	LARP1 ACTN4 DST PLEKHG3 TUBG1	5.35e-04	429	32	5	int:LIMA1
Interaction	RAD51 interactions	MSH6 INO80 TUBG1 RNF20	5.51e-04	241	32	4	int:RAD51
Interaction	RC3H2 interactions	LARP1 R3HDM2 KRT9 IRS4 CDK12 HSPA6	5.58e-04	667	32	6	int:RC3H2
Interaction	DGCR8 interactions	LARP1 MSH6 LARP1B CDK12	5.60e-04	242	32	4	int:DGCR8
Interaction	YWHAG interactions	LARP1 R3HDM2 ACTN4 IRS4 DST LARP1B CDK12 PLEKHG3	5.84e-04	1248	32	8	int:YWHAG
Interaction	MZT2A interactions	TUBG2 TUBG1	6.05e-04	23	32	2	int:MZT2A
Interaction	CDK9 interactions	LARP1 ACTN4 SRCAP CDK12 HSPA6 RNF20	6.42e-04	685	32	6	int:CDK9
Interaction	TRIM33 interactions	LARP1 MSH6 ACTN4 IRS4 TUBG1	6.85e-04	453	32	5	int:TRIM33
Interaction	PABPC1 interactions	LARP1 R3HDM2 ACTN4 LARP1B HAUS1 HSPA6	7.14e-04	699	32	6	int:PABPC1
Interaction	CYP4F12 interactions	BRD2 HSPA6	7.16e-04	25	32	2	int:CYP4F12
Interaction	RNF19A interactions	TUBG2 TUBG1	8.36e-04	27	32	2	int:RNF19A
Interaction	BRD9 interactions	MSH6 INO80 BRD2	8.37e-04	117	32	3	int:BRD9
Interaction	CUL4B interactions	AHR LARP1 KRT9 IRS4 HSPA7 TUBG1	8.83e-04	728	32	6	int:CUL4B
Interaction	POC1A interactions	LARP1B HSPA6 TUBG1	9.44e-04	122	32	3	int:POC1A
Cytoband	17q21	TUBG2 TUBG1	8.95e-04	63	32	2	17q21
GeneFamily	La ribonucleoprotein domain containing\|RNA binding motif containing	LARP1 LARP1B	3.84e-05	7	25	2	625
GeneFamily	Heat shock 70kDa proteins	HSPA6 HSPA7	2.46e-04	17	25	2	583
GeneFamily	Tubulins	TUBG2 TUBG1	5.85e-04	26	25	2	778
ToppCell	facs-Lung-3m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAPGEF1 DST MYO18B JAM2	9.49e-06	187	32	4	7170694a1b86fe8d84d96c880ffe57af09bdc026
ToppCell	droplet-Tongue-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AHR ACTN4 BRD2 CDK12	9.69e-06	188	32	4	d62cc37e86b7b186e53aeb7f421c4e5ee28f23bd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHR COLGALT1 SRCAP HSPA7	1.21e-05	199	32	4	379bbd9cecf466b902411c54d74bd9885285b1ba
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_hypoxia/MES-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RAPGEF1 SRCAP HSPA6 HSPA7	1.24e-05	200	32	4	851c57187db8bc91a393655bca5f13e787a723d4
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	AHR RPGRIP1 RAPGEF1	1.88e-04	156	32	3	0f54d62c0fc08bbdd5ac743b2d5d748c3d1e6ef9
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF1 ADAMTS6 JAM2	2.26e-04	166	32	3	8e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCell	E15.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AHR DST JAM2	2.47e-04	171	32	3	3112d15f2a28cf4a71992db4971d960716dc1264
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	INO80 TUBG2 RNF20	2.55e-04	173	32	3	7e2149205e119cec4f5099c83c85d1e13470137a
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	AHR CORO2B JAM2	2.60e-04	174	32	3	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RAPGEF1 ADAMTS6 JAM2	2.82e-04	179	32	3	1ce8d18f63e8dd2d3db41fbeca4601bd3b305fba
ToppCell	facs-Lung-Endomucin-24m-Myeloid-myeloid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CENPP LARP1B HAUS1	2.82e-04	179	32	3	e520eadde4f1b7fb868dbbe94c4d62b3776c55eb
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	RAPGEF1 ADAMTS6 JAM2	2.82e-04	179	32	3	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST MYO18B JAM2	2.96e-04	182	32	3	aa113a0d2c1d28bda24cbb1221afd21b5628dc6d
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ACTN4 DST JAM2	3.06e-04	184	32	3	8ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACTN4 CORO2B DST	3.11e-04	185	32	3	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACTN4 CORO2B DST	3.11e-04	185	32	3	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ACTN4 CORO2B DST	3.11e-04	185	32	3	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	Control-Endothelial-Endothelial-Artery\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	RAPGEF1 ADAMTS6 JAM2	3.16e-04	186	32	3	2d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	RAPGEF1 ADAMTS6 JAM2	3.21e-04	187	32	3	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACTN4 CORO2B DST	3.21e-04	187	32	3	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORO2B DST COLGALT1	3.31e-04	189	32	3	98f517af255ef234eefc3ed7e6c1d63331ab8af0
ToppCell	droplet-Lung-30m-Hematologic-myeloid-alveolar_macrophage\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CORO2B DST COLGALT1	3.31e-04	189	32	3	f7e9b6e6a4de297b660a5b6c9a62f860c147185e
ToppCell	COVID-19-kidney-AQP1+SLC14A1+EC\|kidney / Disease (COVID-19 only), tissue and cell type	RAPGEF1 ADAMTS6 JAM2	3.36e-04	190	32	3	1519f34d31fe0817184c5865a0bc9f0cb479b1a4
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CORO2B ADAMTS6 JAM2	3.36e-04	190	32	3	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	PBMC-Severe-cDC_12\|Severe / Compartment, Disease Groups and Clusters	CENPP MSH6 TUBG1	3.36e-04	190	32	3	84ee185939bdefb10705b621a70da27701eadcee
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF1 ADAMTS6 JAM2	3.41e-04	191	32	3	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF1 ADAMTS6 JAM2	3.46e-04	192	32	3	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ACTN4 CORO2B DST	3.52e-04	193	32	3	3eaa0461618582a1754400624350d269d24e750a
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF1 ADAMTS6 JAM2	3.57e-04	194	32	3	a429d22c8c9d0fd3bfa9f877a6364cecad68db30
ToppCell	facs-Thymus-Epithelium\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPNS2 DST JAM2	3.57e-04	194	32	3	255d6eead8da740a942a5e7d554dbd895d736d1a
ToppCell	facs-Thymus-Epithelium-24m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CAPNS2 DST JAM2	3.62e-04	195	32	3	cc89261bb091ef978bd73cffc68ccdd00a8786d1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	RAPGEF1 ADAMTS6 JAM2	3.62e-04	195	32	3	d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCell	facs-Brain_Myeloid-Hippocampus\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DST MYO18B JAM2	3.62e-04	195	32	3	a1478021a3ed0e779716393124ca2a7770c433b7
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	DST ADAMTS6 JAM2	3.68e-04	196	32	3	cf7f384c1771274e766bab03ecc3dfbd13f2df60
ToppCell	facs-Trachea-3m\|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ACTN4 PTPRA DST	3.73e-04	197	32	3	e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell	facs-Trachea-nan-3m\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTN4 PTPRA DST	3.73e-04	197	32	3	0353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCell	COVID-19-kidney-AQP1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	RAPGEF1 ADAMTS6 JAM2	3.79e-04	198	32	3	8689090bce9ab6e8f122426a404037e572c6713b
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DST ADAMTS6 JAM2	3.85e-04	199	32	3	9b02acae6325b0ac9642438a4431285ff396e5fe
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DST ADAMTS6 JAM2	3.90e-04	200	32	3	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-NK_activated\|COVID-19_Mild / Disease, condition lineage and cell class	RAPGEF1 SRCAP PLEKHG3	3.90e-04	200	32	3	2281debd86e5d92e8fe0397aec9ef670800f7471
ToppCell	Bronchial_Brush-Epithelial-Basal_2\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	CAPNS2 DST PLEKHG3	3.90e-04	200	32	3	1fa29a9f42987549a75dffeb177099458f7cca88
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
ToppCell	severe-T/NK_proliferative\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CENPP MSH6 TUBG1	3.90e-04	200	32	3	9d6e7e2d6cfa8c96bbb5c187815df96ecaa5475c
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	b2d4e6f3e8e4da62e6b02758ab2ed8f505269f9a
ToppCell	LPS_anti-TNF-Endothelial-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	60d2cbf41f37f1b11eddb4c9d9246c9c1fc5a5af
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Artery\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	DST ADAMTS6 JAM2	3.90e-04	200	32	3	b1ff8d61b567f85006d6d20093f9c803b6d34674
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	DST ADAMTS6 JAM2	3.90e-04	200	32	3	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	AHR DST JAM2	3.90e-04	200	32	3	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Control_saline-Endothelial-Endothelial-Artery\|Control_saline / Treatment groups by lineage, cell group, cell type	DST ADAMTS6 JAM2	3.90e-04	200	32	3	65b71f1e8da5c3750fcd0a2e66d9ef3125a3f78a
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	DST ADAMTS6 JAM2	3.90e-04	200	32	3	ac9ead34afa14067171833f5c277eaf06db7b02e
Disease	complex cortical dysplasia with other brain malformations 4 (implicated_via_orthology)	TUBG2 TUBG1	1.07e-06	2	31	2	DOID:0090138 (implicated_via_orthology)
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	HSPA6 HSPA7	1.44e-04	17	31	2	EFO_0021969
Disease	vital capacity	CENPP AHR INO80 DST MYO18B ADAMTS6 CDK12	2.42e-04	1236	31	7	EFO_0004312
Disease	creatinine measurement, glomerular filtration rate	R3HDM2 INO80 CDK12	2.52e-04	117	31	3	EFO_0004518, EFO_0005208
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	HSPA6 HSPA7	3.16e-04	25	31	2	EFO_0021970
Disease	tea consumption measurement	AHR MSH6 TUBG2	3.35e-04	129	31	3	EFO_0010091
Disease	serum albumin measurement	R3HDM2 LARP1B CDK12 HSPA6 HSPA7	3.53e-04	592	31	5	EFO_0004535
Disease	gastric adenocarcinoma (is_marker_for)	PTPRA CDK12	3.97e-04	28	31	2	DOID:3717 (is_marker_for)
Disease	Neoplasm of uncertain or unknown behavior of ovary	MSH6 CDK12	4.26e-04	29	31	2	C0496920
Disease	Ovarian Carcinoma	MSH6 CDK12	4.56e-04	30	31	2	C0029925
Disease	forced expiratory volume	CENPP LARP1 INO80 DST CDK12	1.29e-03	789	31	5	EFO_0004314
Disease	Adenocarcinoma of lung (disorder)	AHR MSH6 MYO18B	1.31e-03	206	31	3	C0152013

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDIRHMQNEKFFRND	AHR	551	P35869
DMAFKLDRRENDERR	CDK12	86	Q9NYV4
ERALEARMNFDKRQH	CNTRL	891	Q7Z7A1
MFNFKRAQEDISRLR	RNF20	876	Q5VTR2
QEMQQKLEDFRDYRR	ACTN4	326	O43707
RAEERKDLFMFFRSL	CENPP	156	Q6IPU0
SRDFREKQCADFDNM	ADAMTS6	616	Q9UKP5
FQQRFILKRDDASMD	R3HDM2	251	Q9Y2K5
RRDMVADFQNRNDIF	INO80	1156	Q9ULG1
SVDNLERDFFLRRKM	LARP1	416	Q6PKG0
LDDFRIKFEMEQNLR	KRT9	236	P35527
RVMDFFRRIDKDQDG	DST	7201	Q03001
QVRRLEFNQAMDDFK	CUEDC1	41	Q9NWM3
GDFKNRAEMIDFNIR	JAM2	81	P57087
REFEKMNQSLRLFRE	MSH6	1321	P52701
DNRLVNHFMEEFRRK	HSPA7	236	P48741
MFFRQQDEIRRLKEE	CORO2B	441	Q9UQ03
LDAMFRAFKSLDRDR	CAPNS2	216	Q96L46
DNRLVNHFMEEFRRK	HSPA6	236	P17066
DDLRFEIFFKRRLMN	COLGALT1	436	Q8NBJ5
NLERDFFLRGKMDEQ	LARP1B	231	Q659C4
NRRMADDNKLFREEF	PTPRA	231	P18433
MDFARRDNQFDSPKR	IRS4	1241	O14654
MNREELEDSFFRLRE	RPGRIP1	41	Q96KN7
ECMRDKQQAKFFRDR	PLEKHG3	196	A1L390
ERAKVDNRRQNMDFL	HAUS1	171	Q96CS2
EQRQALMERFNADKR	SRCAP	2096	Q6ZRS2
RKMENRDYRDAQEFA	BRD2	401	P25440
MKKNRERFCNREREF	C12orf4	1	Q9NQ89
DMRRNDDIINFFNDF	RAPGEF1	1031	Q13905
REAFLEQFRKEDMFK	TUBG1	401	P23258
RFDCAQMENEFLRKR	MYO18B	1521	Q8IUG5
RDAFLEQFRKEDMFK	TUBG2	401	Q9NRH3