Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein tyrosine kinase binding	BMPR2 CBL CBLB PSG1 PSG3 PSG7	7.58e-07	149	43	6	GO:1990782
GeneOntologyMolecularFunction	granulocyte colony-stimulating factor receptor binding	PSG1 PSG3	4.05e-04	14	43	2	GO:0005130
GeneOntologyMolecularFunction	protein kinase binding	BMPR2 LIPE CAV1 CBL CBLB PSG1 PSG3 PSG7	4.80e-04	873	43	8	GO:0019901
GeneOntologyMolecularFunction	kinase binding	BMPR2 LIPE CAV1 CBL CBLB PSG1 PSG3 PSG7	9.53e-04	969	43	8	GO:0019900
GeneOntologyMolecularFunction	GPI anchor binding	PSG1 PSG3	1.11e-03	23	43	2	GO:0034235
GeneOntologyMolecularFunction	protein heterodimerization activity	HIP1 CAV1 TAF9B PSG1 PSG3	1.58e-03	398	43	5	GO:0046982
GeneOntologyMolecularFunction	filamin binding	PSG1 PSG3	1.77e-03	29	43	2	GO:0031005
GeneOntologyMolecularFunction	Toll-like receptor binding	PSG1 PSG3	1.77e-03	29	43	2	GO:0035325
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH7 MYH7B KIF24	2.09e-03	118	43	3	GO:0003774
GeneOntologyMolecularFunction	bile acid transmembrane transporter activity	PSG1 PSG3	2.43e-03	34	43	2	GO:0015125
GeneOntologyMolecularFunction	phosphatase binding	DZIP3 PSG1 PSG3 SIGLEC10	2.46e-03	264	43	4	GO:0019902
GeneOntologyBiologicalProcess	regulation of epidermal growth factor receptor signaling pathway	HIP1 CBL CBLB PSG1 PSG3	8.44e-07	86	42	5	GO:0042058
GeneOntologyBiologicalProcess	regulation of ERBB signaling pathway	HIP1 CBL CBLB PSG1 PSG3	1.25e-06	93	42	5	GO:1901184
GeneOntologyBiologicalProcess	insulin receptor internalization	CAV1 PSG1 PSG3	4.32e-06	16	42	3	GO:0038016
GeneOntologyBiologicalProcess	negative regulation of protein kinase activity	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	5.37e-06	221	42	6	GO:0006469
GeneOntologyBiologicalProcess	negative regulation of kinase activity	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	7.83e-06	236	42	6	GO:0033673
GeneOntologyBiologicalProcess	epidermal growth factor receptor signaling pathway	HIP1 CBL CBLB PSG1 PSG3	9.00e-06	139	42	5	GO:0007173
GeneOntologyBiologicalProcess	ERBB signaling pathway	HIP1 CBL CBLB PSG1 PSG3	1.78e-05	160	42	5	GO:0038127
GeneOntologyBiologicalProcess	negative regulation of transferase activity	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	1.79e-05	273	42	6	GO:0051348
GeneOntologyBiologicalProcess	regulation of platelet-derived growth factor receptor signaling pathway	HIP1 CBL CBLB	2.48e-05	28	42	3	GO:0010640
GeneOntologyBiologicalProcess	negative regulation of protein tyrosine kinase activity	CAV1 CBL CBLB	3.07e-05	30	42	3	GO:0061099
GeneOntologyBiologicalProcess	receptor internalization	HIP1 CAV1 CBLB PSG1 PSG3	3.31e-05	182	42	5	GO:0031623
GeneOntologyBiologicalProcess	regulation of platelet-derived growth factor receptor-alpha signaling pathway	CBL CBLB	4.03e-05	5	42	2	GO:2000583
GeneOntologyBiologicalProcess	receptor-mediated endocytosis	HIP1 CAV1 CBL CBLB PSG1 PSG3	5.81e-05	337	42	6	GO:0006898
GeneOntologyBiologicalProcess	platelet-derived growth factor receptor-alpha signaling pathway	CBL CBLB	8.45e-05	7	42	2	GO:0035790
GeneOntologyBiologicalProcess	negative regulation of protein phosphorylation	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	1.05e-04	375	42	6	GO:0001933
GeneOntologyBiologicalProcess	entry of bacterium into host cell	CAV1 CBL	1.44e-04	9	42	2	GO:0035635
GeneOntologyBiologicalProcess	negative regulation of phosphorylation	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	1.51e-04	401	42	6	GO:0042326
GeneOntologyBiologicalProcess	DNA-templated transcription elongation	KAT7 PWWP2A POLR2M BRD4	2.08e-04	144	42	4	GO:0006354
GeneOntologyBiologicalProcess	negative regulation of peptidyl-tyrosine phosphorylation	CAV1 CBL CBLB	2.36e-04	59	42	3	GO:0050732
GeneOntologyBiologicalProcess	positive regulation of DNA-templated transcription, elongation	KAT7 PWWP2A BRD4	2.73e-04	62	42	3	GO:0032786
GeneOntologyBiologicalProcess	negative regulation of brown fat cell proliferation	PSG1 PSG3	3.63e-04	14	42	2	GO:0070348
GeneOntologyBiologicalProcess	regulation of protein tyrosine kinase activity	CAV1 CBL CBLB	3.75e-04	69	42	3	GO:0061097
GeneOntologyBiologicalProcess	negative regulation of phosphate metabolic process	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	3.88e-04	478	42	6	GO:0045936
GeneOntologyBiologicalProcess	negative regulation of phosphorus metabolic process	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	3.97e-04	480	42	6	GO:0010563
GeneOntologyBiologicalProcess	platelet-derived growth factor receptor signaling pathway	HIP1 CBL CBLB	4.08e-04	71	42	3	GO:0048008
GeneOntologyBiologicalProcess	regulation of brown fat cell proliferation	PSG1 PSG3	4.18e-04	15	42	2	GO:0070347
GeneOntologyBiologicalProcess	positive regulation of homophilic cell adhesion	PSG1 PSG3	4.18e-04	15	42	2	GO:1903387
GeneOntologyBiologicalProcess	negative regulation of epidermal growth factor-activated receptor activity	CBL CBLB	4.18e-04	15	42	2	GO:0007175
GeneOntologyBiologicalProcess	negative regulation of natural killer cell mediated immune response to tumor cell	PSG1 PSG3	4.18e-04	15	42	2	GO:0002856
GeneOntologyBiologicalProcess	negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	PSG1 PSG3	4.18e-04	15	42	2	GO:0002859
GeneOntologyBiologicalProcess	leukocyte activation	KAT7 CAV1 CBL CBLB PSG1 FER1L5 PSG3 BRD4 SIGLEC10	5.31e-04	1186	42	9	GO:0045321
GeneOntologyBiologicalProcess	brown fat cell proliferation	PSG1 PSG3	5.40e-04	17	42	2	GO:0070342
GeneOntologyBiologicalProcess	insulin catabolic process	PSG1 PSG3	5.40e-04	17	42	2	GO:1901143
GeneOntologyBiologicalProcess	granulocyte colony-stimulating factor signaling pathway	PSG1 PSG3	5.40e-04	17	42	2	GO:0038158
GeneOntologyBiologicalProcess	negative regulation of protein modification process	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	5.58e-04	512	42	6	GO:0031400
GeneOntologyBiologicalProcess	regulation of homophilic cell adhesion	PSG1 PSG3	6.07e-04	18	42	2	GO:1903385
GeneOntologyBiologicalProcess	regulation of cytosolic calcium ion concentration	CAV1 ATP2B3 MYH7B	6.67e-04	84	42	3	GO:0051480
GeneOntologyBiologicalProcess	blood vessel remodeling	BMPR2 PSG1 PSG3	7.39e-04	87	42	3	GO:0001974
GeneOntologyBiologicalProcess	negative regulation of hepatocyte proliferation	PSG1 PSG3	7.51e-04	20	42	2	GO:2000346
GeneOntologyBiologicalProcess	negative regulation of fat cell proliferation	PSG1 PSG3	8.29e-04	21	42	2	GO:0070345
GeneOntologyBiologicalProcess	negative regulation of response to tumor cell	PSG1 PSG3	8.29e-04	21	42	2	GO:0002835
GeneOntologyBiologicalProcess	negative regulation of immune response to tumor cell	PSG1 PSG3	8.29e-04	21	42	2	GO:0002838
GeneOntologyBiologicalProcess	regulation of blood coagulation	CAV1 PSG1 PSG3	8.42e-04	91	42	3	GO:0030193
GeneOntologyBiologicalProcess	regulation of hemostasis	CAV1 PSG1 PSG3	8.97e-04	93	42	3	GO:1900046
GeneOntologyBiologicalProcess	negative regulation of granulocyte differentiation	PSG1 PSG3	9.11e-04	22	42	2	GO:0030853
GeneOntologyBiologicalProcess	regulation of epidermal growth factor-activated receptor activity	CBL CBLB	9.11e-04	22	42	2	GO:0007176
GeneOntologyBiologicalProcess	regulation of response to wounding	CAV1 PSG1 PSG3 SIGLEC10	9.75e-04	217	42	4	GO:1903034
GeneOntologyBiologicalProcess	regulation of coagulation	CAV1 PSG1 PSG3	9.83e-04	96	42	3	GO:0050818
GeneOntologyBiologicalProcess	negative regulation of platelet aggregation	PSG1 PSG3	9.97e-04	23	42	2	GO:0090331
GeneOntologyBiologicalProcess	regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	PSG1 PSG3	9.97e-04	23	42	2	GO:0002858
GeneOntologyBiologicalProcess	positive regulation of vasculogenesis	PSG1 PSG3	1.09e-03	24	42	2	GO:2001214
GeneOntologyBiologicalProcess	regulation of natural killer cell mediated immune response to tumor cell	PSG1 PSG3	1.09e-03	24	42	2	GO:0002855
GeneOntologyBiologicalProcess	natural killer cell mediated cytotoxicity directed against tumor cell target	PSG1 PSG3	1.09e-03	24	42	2	GO:0002420
GeneOntologyBiologicalProcess	regulation of endocytosis	HIP1 CAV1 CBL CBLB FER1L5	1.11e-03	389	42	5	GO:0030100
GeneOntologyBiologicalProcess	common myeloid progenitor cell proliferation	PSG1 PSG3	1.18e-03	25	42	2	GO:0035726
GeneOntologyBiologicalProcess	natural killer cell mediated immune response to tumor cell	PSG1 PSG3	1.18e-03	25	42	2	GO:0002423
GeneOntologyBiologicalProcess	DNA-templated transcription initiation	KAT7 PWWP2A LIPE TAF9B	1.23e-03	231	42	4	GO:0006352
GeneOntologyBiologicalProcess	regulation of DNA-templated transcription elongation	KAT7 PWWP2A BRD4	1.27e-03	105	42	3	GO:0032784
GeneOntologyBiologicalProcess	endocytosis	HIP1 CAV1 CBL CBLB PSG1 FER1L5 PSG3	1.29e-03	827	42	7	GO:0006897
GeneOntologyBiologicalProcess	negative regulation of T cell proliferation	CBLB PSG1 PSG3	1.35e-03	107	42	3	GO:0042130
GeneOntologyBiologicalProcess	regulation of fat cell proliferation	PSG1 PSG3	1.38e-03	27	42	2	GO:0070344
GeneOntologyBiologicalProcess	cell activation	KAT7 CAV1 CBL CBLB PSG1 FER1L5 PSG3 BRD4 SIGLEC10	1.38e-03	1356	42	9	GO:0001775
GeneOntologyBiologicalProcess	regulation of protein kinase activity	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	1.40e-03	611	42	6	GO:0045859
GeneOntologyBiologicalProcess	regulation of lymphocyte activation	CAV1 CBLB PSG1 PSG3 BRD4 SIGLEC10	1.43e-03	614	42	6	GO:0051249
GeneOntologyBiologicalProcess	negative regulation of catalytic activity	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	1.44e-03	615	42	6	GO:0043086
GeneOntologyBiologicalProcess	negative regulation of homotypic cell-cell adhesion	PSG1 PSG3	1.48e-03	28	42	2	GO:0034111
GeneOntologyBiologicalProcess	regulation of vasculogenesis	PSG1 PSG3	1.59e-03	29	42	2	GO:2001212
GeneOntologyBiologicalProcess	female pregnancy	BMPR2 PSG1 PSG3 PSG7	1.62e-03	249	42	4	GO:0007565
GeneOntologyBiologicalProcess	vasculogenesis	CAV1 PSG1 PSG3	1.78e-03	118	42	3	GO:0001570
GeneOntologyBiologicalProcess	positive regulation of epidermal growth factor receptor signaling pathway	HIP1 CBL	1.81e-03	31	42	2	GO:0045742
GeneOntologyBiologicalProcess	negative regulation of platelet activation	PSG1 PSG3	1.81e-03	31	42	2	GO:0010544
GeneOntologyBiologicalProcess	blood circulation	BMPR2 CAV1 PSG1 PSG3 ATP2B3 MYH7B	1.88e-03	648	42	6	GO:0008015
GeneOntologyBiologicalProcess	negative regulation of bone resorption	PSG1 PSG3	1.93e-03	32	42	2	GO:0045779
GeneOntologyBiologicalProcess	fat cell proliferation	PSG1 PSG3	1.93e-03	32	42	2	GO:0070341
GeneOntologyBiologicalProcess	regulation of blood vessel remodeling	PSG1 PSG3	1.93e-03	32	42	2	GO:0060312
GeneOntologyBiologicalProcess	negative regulation of epidermal growth factor receptor signaling pathway	CBL CBLB	1.93e-03	32	42	2	GO:0042059
GeneOntologyBiologicalProcess	tissue remodeling	BMPR2 CAV1 PSG1 PSG3	1.95e-03	262	42	4	GO:0048771
GeneOntologyBiologicalProcess	negative regulation of lymphocyte proliferation	CBLB PSG1 PSG3	2.05e-03	124	42	3	GO:0050672
GeneOntologyBiologicalProcess	regulation of granulocyte differentiation	PSG1 PSG3	2.05e-03	33	42	2	GO:0030852
GeneOntologyBiologicalProcess	positive regulation of ERBB signaling pathway	HIP1 CBL	2.05e-03	33	42	2	GO:1901186
GeneOntologyBiologicalProcess	negative regulation of feeding behavior	PSG1 PSG3	2.05e-03	33	42	2	GO:2000252
GeneOntologyBiologicalProcess	negative regulation of signaling receptor activity	CBL CBLB	2.05e-03	33	42	2	GO:2000272
GeneOntologyBiologicalProcess	regulation of leukocyte cell-cell adhesion	CAV1 CBLB PSG1 PSG3 BRD4	2.05e-03	447	42	5	GO:1903037
GeneOntologyBiologicalProcess	negative regulation of response to wounding	PSG1 PSG3 SIGLEC10	2.15e-03	126	42	3	GO:1903035
GeneOntologyBiologicalProcess	negative regulation of mononuclear cell proliferation	CBLB PSG1 PSG3	2.15e-03	126	42	3	GO:0032945
GeneOntologyBiologicalProcess	negative regulation of vascular permeability	PSG1 PSG3	2.18e-03	34	42	2	GO:0043116
GeneOntologyBiologicalProcess	negative regulation of bone remodeling	PSG1 PSG3	2.18e-03	34	42	2	GO:0046851
GeneOntologyBiologicalProcess	transcription elongation by RNA polymerase II	PWWP2A POLR2M BRD4	2.20e-03	127	42	3	GO:0006368
GeneOntologyBiologicalProcess	regulation of T cell activation	CAV1 CBLB PSG1 PSG3 BRD4	2.28e-03	458	42	5	GO:0050863
GeneOntologyBiologicalProcess	insulin metabolic process	PSG1 PSG3	2.31e-03	35	42	2	GO:1901142
GeneOntologyBiologicalProcess	regulation of kinase activity	CAV1 CBL CBLB PSG1 PSG3 PTPRQ	2.50e-03	686	42	6	GO:0043549
GeneOntologyBiologicalProcess	regulation of fatty acid metabolic process	CAV1 PSG1 PSG3	2.56e-03	134	42	3	GO:0019217
GeneOntologyBiologicalProcess	negative regulation of leukocyte proliferation	CBLB PSG1 PSG3	2.56e-03	134	42	3	GO:0070664
GeneOntologyBiologicalProcess	negative regulation of ERBB signaling pathway	CBL CBLB	2.58e-03	37	42	2	GO:1901185
GeneOntologyBiologicalProcess	regulation of leukocyte activation	CAV1 CBLB PSG1 PSG3 BRD4 SIGLEC10	2.65e-03	694	42	6	GO:0002694
GeneOntologyBiologicalProcess	regulation of hepatocyte proliferation	PSG1 PSG3	2.72e-03	38	42	2	GO:2000345
GeneOntologyBiologicalProcess	T cell activation	KAT7 CAV1 CBLB PSG1 PSG3 BRD4	2.79e-03	701	42	6	GO:0042110
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	POLR2M POLR1A TAF9B PSG1 PSG3 BRD4	3.38e-05	335	39	6	GO:0061695
GeneOntologyCellularComponent	caveola	BMPR2 LIPE CAV1 CBL	5.37e-05	111	39	4	GO:0005901
GeneOntologyCellularComponent	plasma membrane raft	BMPR2 LIPE CAV1 CBL	1.59e-04	147	39	4	GO:0044853
GeneOntologyCellularComponent	apical plasma membrane	FAT1 BMPR2 CAV1 PSG1 PSG3 PTPRQ	2.63e-04	487	39	6	GO:0016324
GeneOntologyCellularComponent	transferase complex	KAT7 DEPDC5 POLR2M POLR1A TAF9B PSG1 PSG3 BRD4	3.39e-04	963	39	8	GO:1990234
GeneOntologyCellularComponent	anchoring junction	POLR2M FAT1 BMPR2 CAV1 CBL PSG1 PSG3 RPL7A	3.71e-04	976	39	8	GO:0070161
GeneOntologyCellularComponent	transforming growth factor beta ligand-receptor complex	PSG1 PSG3	4.00e-04	16	39	2	GO:0070021
GeneOntologyCellularComponent	basal plasma membrane	BMPR2 CAV1 PSG1 PSG3 PTPRQ	4.86e-04	354	39	5	GO:0009925
GeneOntologyCellularComponent	membrane raft	BMPR2 LIPE CAV1 CBL CBLB	5.38e-04	362	39	5	GO:0045121
GeneOntologyCellularComponent	membrane microdomain	BMPR2 LIPE CAV1 CBL CBLB	5.51e-04	364	39	5	GO:0098857
GeneOntologyCellularComponent	basal part of cell	BMPR2 CAV1 PSG1 PSG3 PTPRQ	6.54e-04	378	39	5	GO:0045178
GeneOntologyCellularComponent	receptor complex	BMPR2 GRIN2D PSG1 PSG3 PTPRQ SACM1L	6.71e-04	581	39	6	GO:0043235
GeneOntologyCellularComponent	apical part of cell	FAT1 BMPR2 CAV1 PSG1 PSG3 PTPRQ	7.41e-04	592	39	6	GO:0045177
GeneOntologyCellularComponent	nuclear DNA-directed RNA polymerase complex	POLR2M POLR1A TAF9B	1.22e-03	113	39	3	GO:0055029
GeneOntologyCellularComponent	DNA-directed RNA polymerase complex	POLR2M POLR1A TAF9B	1.32e-03	116	39	3	GO:0000428
GeneOntologyCellularComponent	RNA polymerase complex	POLR2M POLR1A TAF9B	1.42e-03	119	39	3	GO:0030880
GeneOntologyCellularComponent	plasma membrane protein complex	CAV1 GRIN2D CBL PSG1 PSG3 SACM1L	3.11e-03	785	39	6	GO:0098797
GeneOntologyCellularComponent	serine/threonine protein kinase complex	PSG1 PSG3 BRD4	3.12e-03	157	39	3	GO:1902554
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	GRIN2D SACM1L	3.19e-03	45	39	2	GO:0008328
GeneOntologyCellularComponent	protein kinase complex	PSG1 PSG3 BRD4	3.90e-03	170	39	3	GO:1902911
GeneOntologyCellularComponent	neurotransmitter receptor complex	GRIN2D SACM1L	3.93e-03	50	39	2	GO:0098878
GeneOntologyCellularComponent	plasma membrane signaling receptor complex	GRIN2D PSG1 PSG3 SACM1L	4.00e-03	350	39	4	GO:0098802
HumanPheno	Abnormal pulmonary artery morphology	DEPDC5 CEP295 BMPR2 POLR1A CBL BRD4	7.16e-07	133	14	6	HP:0030966
HumanPheno	Abnormality of the pulmonary artery	DEPDC5 CEP295 BMPR2 CAV1 POLR1A CBL BRD4	2.99e-06	274	14	7	HP:0004414
HumanPheno	Abnormality of the pulmonary vasculature	DEPDC5 CEP295 BMPR2 CAV1 POLR1A CBL BRD4	2.78e-05	383	14	7	HP:0004930
HumanPheno	Pulmonary artery stenosis	DEPDC5 CEP295 POLR1A CBL	6.07e-05	84	14	4	HP:0004415
MousePheno	enlarged stomach	ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.14e-06	33	34	4	MP:0003883
MousePheno	abnormal skeletal muscle cell glucose uptake	LIPE CBL PSG1 PSG3	4.83e-06	47	34	4	MP:0031617
MousePheno	abnormal muscle cell glucose uptake	LIPE CBL PSG1 PSG3	2.01e-05	67	34	4	MP:0004130
MousePheno	decreased skeletal muscle cell glucose uptake	LIPE PSG1 PSG3	8.16e-05	35	34	3	MP:0031618
MousePheno	increased food intake	LIPE CAV1 CBL PSG1 PSG3	8.67e-05	189	34	5	MP:0011939
MousePheno	abnormal muscle triglyceride level	LIPE PSG1 PSG3	8.89e-05	36	34	3	MP:0031412
MousePheno	abnormal oxygen consumption	LIPE CAV1 CBL PSG1 PSG3	1.00e-04	195	34	5	MP:0005288
MousePheno	abnormal cellular glucose uptake	LIPE CBL PSG1 PSG3	1.05e-04	102	34	4	MP:0003925
MousePheno	decreased muscle cell glucose uptake	LIPE PSG1 PSG3	1.13e-04	39	34	3	MP:0030022
MousePheno	decreased triglyceride level	LIPE CAV1 GRIN2D CBL PSG1 PSG3	1.70e-04	348	34	6	MP:0005318
MousePheno	abnormal mammary fat pad morphology	CAV1 CBL	2.05e-04	9	34	2	MP:0008904
MousePheno	abnormal circulating leptin level	LIPE CAV1 CBL PSG1 PSG3	2.45e-04	236	34	5	MP:0005667
MousePheno	decreased lipid level	POLR2M LIPE CAV1 GRIN2D CBL PSG1 PSG3 MYH7B	2.80e-04	727	34	8	MP:0014461
MousePheno	decreased cellular glucose uptake	LIPE PSG1 PSG3	2.83e-04	53	34	3	MP:0003926
MousePheno	abnormal sternum morphology	BMPR2 ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	3.51e-04	255	34	5	MP:0000157
MousePheno	abnormal glycogen homeostasis	LIPE CAV1 PSG1 PSG3	3.94e-04	144	34	4	MP:0005438
MousePheno	abnormal abdominal fat pad morphology	LIPE CAV1 CBL PSG1 PSG3	3.97e-04	262	34	5	MP:0000010
MousePheno	decreased circulating triglyceride level	LIPE GRIN2D CBL PSG1 PSG3	4.95e-04	275	34	5	MP:0002644
MousePheno	pulmonary hypertension	BMPR2 CAV1	5.13e-04	14	34	2	MP:0003548
MousePheno	increased pulmonary artery pressure	BMPR2 CAV1	5.91e-04	15	34	2	MP:0004012
MousePheno	abnormal vascular wound healing	CAV1 PSG1 PSG3	7.28e-04	73	34	3	MP:0004883
MousePheno	abnormal pectoral girdle bone morphology	BMPR2 ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	7.46e-04	301	34	5	MP:0004508
MousePheno	decreased susceptibility to Coronaviridae infection induced morbidity/mortality	PSG1 PSG3	7.63e-04	17	34	2	MP:0031047
MousePheno	abnormal pulmonary pressure	BMPR2 CAV1	7.63e-04	17	34	2	MP:0003547
MousePheno	abnormal thoracic cage morphology	BMPR2 ANKRD20A3P ANKRD20A8P CAV1 ANKRD20A4P ANKRD20A1	7.81e-04	463	34	6	MP:0004624
MousePheno	abnormal respiratory quotient	CAV1 CBL PSG1 PSG3	8.75e-04	178	34	4	MP:0004129
MousePheno	abnormal energy expenditure	LIPE CAV1 CBL PSG1 PSG3	8.90e-04	313	34	5	MP:0005450
MousePheno	abnormal fat pad morphology	LIPE CAV1 CBL PSG1 PSG3	9.03e-04	314	34	5	MP:0005334
MousePheno	polyphagia	CBL PSG1 PSG3	9.50e-04	80	34	3	MP:0001433
MousePheno	abnormal energy homeostasis	LIPE CAV1 CBL PSG1 PSG3	1.01e-03	322	34	5	MP:0005448
MousePheno	abnormal brown adipose tissue amount	LIPE CAV1 CBL	1.02e-03	82	34	3	MP:0001778
MousePheno	abnormal appendicular skeleton morphology	BMPR2 ANKRD20A3P ANKRD20A8P CAV1 ANKRD20A4P EMSY ANKRD20A1 BRD4	1.12e-03	896	34	8	MP:0009250
MousePheno	increased skeletal muscle triglyceride level	PSG1 PSG3	1.17e-03	21	34	2	MP:0031415
MousePheno	insulin resistance	LIPE CAV1 PSG1 PSG3	1.27e-03	197	34	4	MP:0005331
MousePheno	decreased white adipose tissue amount	LIPE CAV1 CBL	1.34e-03	90	34	3	MP:0001783
MousePheno	abnormal circulating triglyceride level	LIPE CAV1 GRIN2D CBL PSG1 PSG3	1.37e-03	516	34	6	MP:0011969
Domain	Cbl_N	CBL CBLB	1.21e-05	3	38	2	PF02262
Domain	Adaptor_Cbl_EF_hand-like	CBL CBLB	1.21e-05	3	38	2	IPR014741
Domain	Adaptor_Cbl_SH2-like	CBL CBLB	1.21e-05	3	38	2	IPR014742
Domain	Adaptor_Cbl_N_hlx	CBL CBLB	1.21e-05	3	38	2	IPR003153
Domain	CBL_PTB	CBL CBLB	1.21e-05	3	38	2	PS51506
Domain	Adaptor_Cbl	CBL CBLB	1.21e-05	3	38	2	IPR024162
Domain	Cbl_PTB	CBL CBLB	1.21e-05	3	38	2	IPR024159
Domain	Cbl_N2	CBL CBLB	1.21e-05	3	38	2	PF02761
Domain	Cbl_N3	CBL CBLB	1.21e-05	3	38	2	PF02762
Domain	-	CBL CBLB	1.21e-05	3	38	2	1.20.930.20
Domain	Ig_2	PSG1 PSG3 PSG7 SIGLEC10	1.43e-05	73	38	4	PF13895
Domain	V-set	PSG1 PSG3 PSG7 SIGLEC10	5.18e-04	184	38	4	PF07686
Domain	ig	PSG1 PSG3 PSG7 SIGLEC10	5.84e-04	190	38	4	PF00047
Domain	Immunoglobulin	PSG1 PSG3 PSG7 SIGLEC10	5.84e-04	190	38	4	IPR013151
Domain	Ig_V-set	PSG1 PSG3 PSG7 SIGLEC10	6.95e-04	199	38	4	IPR013106
Domain	Ank_2	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	9.27e-04	215	38	4	PF12796
Domain	Ank	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.15e-03	228	38	4	PF00023
Domain	IGc2	PSG1 PSG3 PSG7 SIGLEC10	1.29e-03	235	38	4	SM00408
Domain	Ig_sub2	PSG1 PSG3 PSG7 SIGLEC10	1.29e-03	235	38	4	IPR003598
Domain	-	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.57e-03	248	38	4	1.25.40.20
Domain	ANK	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.64e-03	251	38	4	SM00248
Domain	ANK_REPEAT	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.69e-03	253	38	4	PS50088
Domain	UBA	CBL CBLB	1.69e-03	30	38	2	SM00165
Domain	Ankyrin_rpt-contain_dom	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.71e-03	254	38	4	IPR020683
Domain	ANK_REP_REGION	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.71e-03	254	38	4	PS50297
Domain	Ankyrin_rpt	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	1.92e-03	262	38	4	IPR002110
Domain	UBA	CBL CBLB	2.43e-03	36	38	2	PF00627
Domain	UBA	CBL CBLB	3.61e-03	44	38	2	IPR015940
Domain	UBA	CBL CBLB	4.11e-03	47	38	2	PS50030
Domain	Znf_C3HC4_RING-type	DZIP3 CBL CBLB	5.11e-03	172	38	3	IPR018957
Domain	UBA-like	CBL CBLB	7.51e-03	64	38	2	IPR009060
Pathway	WP_EGFR1_SIGNALING_PATHWAY	HIP1 CAV1 CBL CBLB PSG1 PSG3	2.90e-06	188	31	6	MM15828
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.41e-10	8	43	4	12634303
Pubmed	Association of a new c-Cbl related protein with the very first stages of apoptosis induction.	CBL CBLB	1.49e-06	2	43	2	12102152
Pubmed	Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.	CBL CBLB	1.49e-06	2	43	2	32584413
Pubmed	A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.	CBL CBLB	1.49e-06	2	43	2	27276677
Pubmed	Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.	CBL CBLB	1.49e-06	2	43	2	17475912
Pubmed	Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.	CBL CBLB	1.49e-06	2	43	2	25871390
Pubmed	Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.	CBL CBLB	1.49e-06	2	43	2	26177294
Pubmed	Schistosomiasis-associated pulmonary hypertension unveils disrupted murine gut-lung microbiome and reduced endoprotective Caveolin-1/BMPR2 expression.	BMPR2 CAV1	1.49e-06	2	43	2	37908354
Pubmed	The role of E3 ubiquitin ligase Cbl proteins in β-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells.	CBL CBLB	1.49e-06	2	43	2	23665906
Pubmed	Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.	CBL CBLB	1.49e-06	2	43	2	24994594
Pubmed	Molecular cloning of a cDNA for human pregnancy-specific beta 1-glycoprotein:homology with human carcinoembryonic antigen and related proteins.	PSG1 PSG3	1.49e-06	2	43	2	3265688
Pubmed	Caveolin-1 regulates BMPRII localization and signaling in vascular smooth muscle cells.	BMPR2 CAV1	1.49e-06	2	43	2	18725205
Pubmed	Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.	CBL CBLB	1.49e-06	2	43	2	17056522
Pubmed	c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.	CBL CBLB	1.49e-06	2	43	2	12415267
Pubmed	UBASH3A Regulates the Synthesis and Dynamics of TCR-CD3 Complexes.	HIP1 CBL CBLB	1.98e-06	20	43	3	31659016
Pubmed	Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance.	CBL CBLB	4.48e-06	3	43	2	20038312
Pubmed	Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes.	CBL CBLB	4.48e-06	3	43	2	37903221
Pubmed	Regulation of immune responses by E3 ubiquitin-protein ligases.	CBL CBLB	4.48e-06	3	43	2	11826757
Pubmed	Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.	CBL CBLB	4.48e-06	3	43	2	19268472
Pubmed	Cbl negatively regulates JNK activation and cell death.	CBL CBLB	4.48e-06	3	43	2	19546888
Pubmed	Structure, evolution and chromosomal localization of the human pregnancy-specific beta 1 glycoprotein gene family.	PSG1 PSG3	4.48e-06	3	43	2	2341148
Pubmed	The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes.	CBL CBLB	4.48e-06	3	43	2	17330819
Pubmed	Cbl-b regulates the CD28 dependence of T-cell activation.	CBL CBLB	4.48e-06	3	43	2	10646609
Pubmed	Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix.	CBL CBLB	4.48e-06	3	43	2	25744063
Pubmed	A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.	CBL CBLB	4.48e-06	3	43	2	18316398
Pubmed	A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.	CBL CBLB	4.48e-06	3	43	2	10074432
Pubmed	E3 ubiquitin ligases Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer.	CBL CBLB	4.48e-06	3	43	2	29364514
Pubmed	Mutations in BMPR2 are not present in patients with pulmonary hypertension associated with congenital diaphragmatic hernia.	BMPR2 CAV1	4.48e-06	3	43	2	28162765
Pubmed	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	CBL CBLB	4.48e-06	3	43	2	12874286
Pubmed	Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.	CBL CBLB	4.48e-06	3	43	2	31282857
Pubmed	Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning.	PSG1 PSG3	4.48e-06	3	43	2	2350345
Pubmed	c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.	CBL CBLB	4.48e-06	3	43	2	21768087
Pubmed	Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights.	CBL CBLB	4.48e-06	3	43	2	18596201
Pubmed	Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.	CBL CBLB	4.48e-06	3	43	2	15265912
Pubmed	[Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].	CBL CBLB	4.48e-06	3	43	2	21645455
Pubmed	Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.	CBL CBLB	4.48e-06	3	43	2	34630435
Pubmed	Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling.	BMPR2 CAV1	4.48e-06	3	43	2	28188225
Pubmed	Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).	CBL CBLB	4.48e-06	3	43	2	15315962
Pubmed	T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation.	CBL CBLB	4.48e-06	3	43	2	23684068
Pubmed	The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.	CBL CBLB	4.48e-06	3	43	2	27048651
Pubmed	Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.	CBL CBLB	4.48e-06	3	43	2	15273720
Pubmed	Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.	CBL CBLB	4.48e-06	3	43	2	11087752
Pubmed	Cbl regulates the activity of SIRT2.	CBL CBLB	4.48e-06	3	43	2	25285640
Pubmed	VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.	CBL CBLB	4.48e-06	3	43	2	27449297
Pubmed	The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.	CBL CBLB	4.48e-06	3	43	2	38170572
Pubmed	Dynamics and interaction of caveolin-1 isoforms with BMP-receptors.	BMPR2 CAV1	4.48e-06	3	43	2	15657086
Pubmed	LYAR potentiates rRNA synthesis by recruiting BRD2/4 and the MYST-type acetyltransferase KAT7 to rDNA.	KAT7 BRD4	8.94e-06	4	43	2	31504794
Pubmed	IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.	CBL CBLB	8.94e-06	4	43	2	29237719
Pubmed	CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.	CBL CBLB	8.94e-06	4	43	2	29729186
Pubmed	Pulmonary arterial hypertension: the clinical syndrome.	BMPR2 CAV1	8.94e-06	4	43	2	24951762
Pubmed	Cbl promotes clustering of endocytic adaptor proteins.	CBL CBLB	8.94e-06	4	43	2	16228008
Pubmed	An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.	CBL CBLB	8.94e-06	4	43	2	28100467
Pubmed	Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.	CBL CBLB	8.94e-06	4	43	2	19815501
Pubmed	Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.	CBL CBLB	8.94e-06	4	43	2	20951942
Pubmed	QRFP-43 inhibits lipolysis by preventing ligand-induced complex formation between perilipin A, caveolin-1, the catalytic subunit of protein kinase and hormone-sensitive lipase in 3T3-L1 adipocytes.	LIPE CAV1	8.94e-06	4	43	2	25677823
Pubmed	Inhibitory role of proguanil on the growth of bladder cancer via enhancing EGFR degradation and inhibiting its downstream signaling pathway to induce autophagy.	CAV1 CBL	8.94e-06	4	43	2	35614042
Pubmed	H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.	CBL CBLB	8.94e-06	4	43	2	26353930
Pubmed	The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.	CBL CBLB	8.94e-06	4	43	2	12935897
Pubmed	Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.	CBL CBLB	8.94e-06	4	43	2	20805496
Pubmed	The pregnancy-specific glycoprotein family of the immunoglobulin superfamily: identification of new members and estimation of family size.	PSG1 PSG7	8.94e-06	4	43	2	1572651
Pubmed	Evidence for direct interaction between Sprouty and Cbl.	CBL CBLB	8.94e-06	4	43	2	11053437
Pubmed	CCL5 deficiency rescues pulmonary vascular dysfunction, and reverses pulmonary hypertension via caveolin-1-dependent BMPR2 activation.	BMPR2 CAV1	8.94e-06	4	43	2	29374556
Pubmed	c-Cbl and Cbl-b act redundantly to protect osteoclasts from apoptosis and to displace HDAC6 from beta-tubulin, stabilizing microtubules and podosomes.	CBL CBLB	1.49e-05	5	43	2	19641021
Pubmed	Loss of Cbl-PI3K interaction enhances osteoclast survival due to p21-Ras mediated PI3K activation independent of Cbl-b.	CBL CBLB	1.49e-05	5	43	2	24470255
Pubmed	Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.	CBL CBLB	1.49e-05	5	43	2	17020880
Pubmed	Regulation of LFA-1-dependent inflammatory cell recruitment by Cbl-b and 14-3-3 proteins.	CBL CBLB	1.49e-05	5	43	2	18239087
Pubmed	C-Cbl reverses HER2-mediated tamoxifen resistance in human breast cancer cells.	CAV1 CBL	1.49e-05	5	43	2	29720121
Pubmed	Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole.	PSG1 PSG7	1.49e-05	5	43	2	2377620
Pubmed	Establishment of the major compatibility complex-dependent development of CD4+ and CD8+ T cells by the Cbl family proteins.	CBL CBLB	1.49e-05	5	43	2	17045823
Pubmed	Control of the B cell-intrinsic tolerance programs by ubiquitin ligases Cbl and Cbl-b.	CBL CBLB	2.23e-05	6	43	2	17493844
Pubmed	p85beta phosphoinositide 3-kinase regulates CD28 coreceptor function.	CBL CBLB	2.23e-05	6	43	2	19190244
Pubmed	A positive regulatory role for Cbl family proteins in tumor necrosis factor-related activation-induced cytokine (trance) and CD40L-mediated Akt activation.	CBL CBLB	2.23e-05	6	43	2	11406619
Pubmed	cbl-b inhibits epidermal growth factor receptor signaling.	CBL CBLB	2.23e-05	6	43	2	10086340
Pubmed	SHIP2 (SH2 domain-containing inositol phosphatase 2) SH2 domain negatively controls SHIP2 monoubiquitination in response to epidermal growth factor.	CBL CBLB	2.23e-05	6	43	2	19880507
Pubmed	Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.	CBL CBLB	2.23e-05	6	43	2	10635327
Pubmed	An Mtb-Human Protein-Protein Interaction Map Identifies a Switch between Host Antiviral and Antibacterial Responses.	CBL CBLB	2.23e-05	6	43	2	30118682
Pubmed	Recruitment of Sprouty1 to immune synapse regulates T cell receptor signaling.	CBL CBLB	2.23e-05	6	43	2	19915061
Pubmed	CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.	CBL CBLB	2.23e-05	6	43	2	21346257
Pubmed	CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery.	CBL CBLB	3.12e-05	7	43	2	17255943
Pubmed	Negative feedback control of osteoclast formation through ubiquitin-mediated down-regulation of NFATc1.	CBL CBLB	3.12e-05	7	43	2	20037154
Pubmed	Deficiency of CBL and CBLB ubiquitin ligases leads to hyper T follicular helper cell responses and lupus by reducing BCL6 degradation.	CBL CBLB	3.12e-05	7	43	2	38761804
Pubmed	DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells.	CBL CBLB	3.12e-05	7	43	2	28972304
Pubmed	The roles of Cbl-b and c-Cbl in insulin-stimulated glucose transport.	CBL CBLB	3.12e-05	7	43	2	12842890
Pubmed	Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants.	PSG1 PSG7	3.12e-05	7	43	2	7794280
Pubmed	Co-recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR-induced ubiquitylation.	CBL CBLB	3.12e-05	7	43	2	27474268
Pubmed	Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.	CBL CBLB	4.16e-05	8	43	2	14661060
Pubmed	Alternative splicing affecting the SH3A domain controls the binding properties of intersectin 1 in neurons.	CBL CBLB	5.35e-05	9	43	2	18539136
Pubmed	CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.	CBL CBLB	5.35e-05	9	43	2	12177062
Pubmed	Activated Cdc42-associated kinase 1 is a component of EGF receptor signaling complex and regulates EGF receptor degradation.	CBL CBLB	5.35e-05	9	43	2	17182860
Pubmed	Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation.	CBL SIGLEC10	5.35e-05	9	43	2	23374343
Pubmed	The Csk-Associated Adaptor PAG Inhibits Effector T Cell Activation in Cooperation with Phosphatase PTPN22 and Dok Adaptors.	CBL CBLB	5.35e-05	9	43	2	27926878
Pubmed	Stromal-cell-derived factor-1/CXCL12-induced chemotaxis of a T cell line involves intracellular signaling through Cbl and Cbl-b and their regulation by Src kinases and CD45.	CBL CBLB	6.68e-05	10	43	2	16503409
Pubmed	Heritable Pulmonary Arterial Hypertension Overview	BMPR2 CAV1	6.68e-05	10	43	2	20301658
Pubmed	Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction.	CBL CBLB	8.15e-05	11	43	2	29562201
Pubmed	DNA sequence and analysis of human chromosome 9.	ANKRD20A2P ANKRD20A3P ANKRD20A4P KIF24 ANKRD20A1	9.16e-05	370	43	5	15164053
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	DNAH7 EMSY BRD4	1.12e-04	75	43	3	25593309
Pubmed	Regulation of hepatic fibrosis by carcinoembryonic antigen-related cell adhesion molecule 1.	PSG1 PSG3	1.15e-04	13	43	2	34058224
Pubmed	A mouse carcinoembryonic antigen gene family member is a calcium-dependent cell adhesion molecule.	PSG1 PSG3	1.15e-04	13	43	2	1985902
Pubmed	Amino acid substitutions and an insertion in the spike glycoprotein extend the host range of the murine coronavirus MHV-A59.	PSG1 PSG3	1.15e-04	13	43	2	15207636
Pubmed	Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture.	PSG1 PSG3	1.15e-04	13	43	2	19285068
Interaction	ANKRD20A4P interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	1.80e-07	6	43	3	int:ANKRD20A4P
Interaction	ANKRD20A2P interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	3.15e-07	7	43	3	int:ANKRD20A2P
Interaction	ANKRD20A1 interactions	ANKRD20A2P ANKRD20A4P ANKRD20A1	1.48e-06	11	43	3	int:ANKRD20A1
Interaction	PTPN6 interactions	CAV1 CBL CBLB RPL7A PTPRQ SIGLEC10	2.59e-05	278	43	6	int:PTPN6
Cytoband	19q13.2	LIPE PSG1 PSG3 PSG7	1.91e-05	164	44	4	19q13.2
Cytoband	9p12	ANKRD20A2P ANKRD20A3P	3.59e-04	29	44	2	9p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	LIPE GRIN2D PSG1 PSG3 PSG7 SIGLEC10	9.19e-04	1192	44	6	chr19q13
GeneFamily	CD molecules\|V-set domain containing\|Pregnancy specific glycoproteins	PSG1 PSG3 PSG7	9.05e-07	11	33	3	1315
GeneFamily	Ankyrin repeat domain containing	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	9.44e-04	242	33	4	403
GeneFamily	RNA polymerase subunits	POLR2M POLR1A	1.27e-03	29	33	2	726
GeneFamily	Adenosine receptors\|V-set domain containing	PSG1 PSG3 SIGLEC10	3.22e-03	163	33	3	590
ToppCell	COPD-Myeloid-cDC1\|COPD / Disease state, Lineage and Cell class	ANKRD20A2P FOXN2 ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1 SIGLEC10	7.74e-10	192	44	7	bd3d00b094d92463b06023361a71240851a542b8
ToppCell	IPF-Myeloid-cDC1\|IPF / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1 SIGLEC10	3.04e-08	188	44	6	2331a2bae1383820d598e93aa86c75b101069bac
ToppCell	Control-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.03e-06	184	44	5	c6affa0b12510363258f65e46bf2d47bf4a8e75f
ToppCell	COPD-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.03e-06	184	44	5	42d7ce104cd7bcb83fbbbd0e7d3267ad07edfa94
ToppCell	IPF-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.09e-06	186	44	5	962c2dada19185628ead77c32fcb07fa95114247
ToppCell	Control-Myeloid-cDC1\|Control / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.09e-06	186	44	5	b05c394aa3573ba855abc3066739ca193883b0c3
ToppCell	IPF-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.15e-06	188	44	5	47bb6caf84f70a1cda7d09803afdfd5182772e66
ToppCell	COPD-Myeloid-cDC1\|Myeloid / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A8P ANKRD20A4P ANKRD20A1	1.24e-06	191	44	5	3480e6d27dd4291765bbbb2acdb6a2e4f02c8085
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-dn_T\|ICU-NoSEP / Disease, condition lineage and cell class	DZIP3 POLR2M CAV1 TAF9B CBLB	1.52e-06	199	44	5	7fb211f803a8b3a2cfa9455386abea08131c6b52
ToppCell	Control-Myeloid-cDC1\|World / Disease state, Lineage and Cell class	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	3.37e-05	186	44	4	3de803dee3ef10eb85a2b47d3f93385214e5b0ff
ToppCell	Control-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	ANKRD20A2P FAT1 BMPR2 ANKRD20A4P	3.67e-05	190	44	4	7f3f419fffe02934b6f27b697f7a6401072491ed
ToppCell	severe-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DZIP3 FAT1 CAV1 CBLB	4.14e-05	196	44	4	14baf176bce5750ef50d6838b748caf68c151e05
ToppCell	COPD-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	ANKRD20A2P BMPR2 ANKRD20A3P ANKRD20A4P	4.22e-05	197	44	4	30dbc05ea66892d2e18ff375ffa86d1db7bc4083
ToppCell	(5)_Dendritic_cell-(53)_Lymphoid_DC\|(5)_Dendritic_cell / shred on Cell_type and subtype	CAV1 ANKRD20A4P CBLB ANKRD20A1	4.30e-05	198	44	4	548da5fa86f9756c503ed77bcdde55bc4d1a2726
ToppCell	mLN-(5)_Dendritic_cell-(53)_Lymphoid_DC\|mLN / shred on region, Cell_type, and subtype	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	4.30e-05	198	44	4	da84c76afe835aeee39da04b63c03549218b5d91
ToppCell	mLN-Dendritic_cell-Lymphoid_DC\|mLN / Region, Cell class and subclass	ANKRD20A2P ANKRD20A3P ANKRD20A4P ANKRD20A1	4.30e-05	198	44	4	3965a9f1e8a51a196e5349aaca5fa5ed1cd8ee92
ToppCell	severe-dn_T\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DZIP3 FAT1 CAV1 CBLB	4.30e-05	198	44	4	d4f2213af45ada47e6c62675f468ce05692db507
Computational	Neighborhood of CDKN1C	PSG1 PSG3 PSG7	3.54e-05	27	26	3	GNF2_CDKN1C
Computational	Neighborhood of EGFR	PSG1 PSG3 PSG7	5.95e-05	32	26	3	GNF2_EGFR
Computational	Neighborhood of IGFBP1	PSG1 PSG3 PSG7	7.81e-05	35	26	3	GNF2_IGFBP1
Computational	Neighborhood of MMP11	PSG1 PSG3 PSG7	1.35e-04	42	26	3	GNF2_MMP11
Computational	Neighborhood of TIMP2	PSG1 PSG3 PSG7	1.78e-04	46	26	3	GNF2_TIMP2
Computational	Neighborhood of KISS1	PSG1 PSG3 PSG7	2.15e-04	49	26	3	GNF2_KISS1
Disease	Heritable pulmonary arterial hypertension	BMPR2 CAV1	9.67e-06	4	38	2	cv:C0340543
Disease	Idiopathic pulmonary arterial hypertension	BMPR2 CAV1	1.61e-05	5	38	2	cv:C3203102
Disease	Primary pulmonary hypertension	BMPR2 CAV1	1.61e-05	5	38	2	cv:C0152171
Disease	Idiopathic and/or familial pulmonary arterial hypertension	BMPR2 CAV1	1.61e-05	5	38	2	cv:C5679820
Disease	primary pulmonary hypertension (is_implicated_in)	BMPR2 CAV1	2.41e-05	6	38	2	DOID:14557 (is_implicated_in)
Disease	Pulmonary Hypertension, Primary, 1	BMPR2 CAV1	3.38e-05	7	38	2	C4552070
Disease	Familial Partial Lipodystrophy, Type 3	LIPE CAV1	3.38e-05	7	38	2	C1720861
Disease	Familial Partial Lipodystrophy, Type 2	LIPE CAV1	3.38e-05	7	38	2	C1720860
Disease	Familial Partial Lipodystrophy, Type 1	LIPE CAV1	3.38e-05	7	38	2	C1720859
Disease	PULMONARY HYPERTENSION, PRIMARY, DEXFENFLURAMINE-ASSOCIATED	BMPR2 CAV1	3.38e-05	7	38	2	C1969342
Disease	Pulmonary Hypertension, Primary, Fenfluramine-Associated	BMPR2 CAV1	3.38e-05	7	38	2	C1969343
Disease	Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia	BMPR2 CAV1	3.38e-05	7	38	2	C3714844
Disease	Familial pulmonary arterial hypertension	BMPR2 CAV1	4.50e-05	8	38	2	C1701939
Disease	Familial partial lipodystrophy	LIPE CAV1	4.50e-05	8	38	2	C0271694
Disease	reticulocyte measurement	FOXN2 DEPDC5 FAT1 BMPR2 CAV1 CBL PSG1 BRD4	4.83e-05	1053	38	8	EFO_0010700
Disease	Pulmonary arterial hypertension	BMPR2 CAV1	7.22e-05	10	38	2	C2973725
Disease	2-oxo-hept-3-ene-1,7-dioate hydratase activity	BMPR2 CAV1	1.46e-04	14	38	2	C1150929
Disease	Idiopathic pulmonary arterial hypertension	BMPR2 CAV1	1.92e-04	16	38	2	C3203102
Disease	Familial primary pulmonary hypertension	BMPR2 CAV1	2.17e-04	17	38	2	C0340543
Disease	cD177 antigen measurement	PSG1 PSG7	2.44e-04	18	38	2	EFO_0021866
Disease	reticulocyte count	DZIP3 FOXN2 DEPDC5 FAT1 CAV1 CBL PSG1	3.31e-04	1045	38	7	EFO_0007986
Disease	hypertrophic cardiomyopathy (implicated_via_orthology)	CAV1 MYH7B	6.41e-04	29	38	2	DOID:11984 (implicated_via_orthology)
Disease	cardiac arrhythmia	CAV1 GORAB	6.87e-04	30	38	2	EFO_0004269
Disease	lung non-small cell carcinoma (is_implicated_in)	FAT1 CBL CBLB	7.65e-04	139	38	3	DOID:3908 (is_implicated_in)
Disease	melanoma (is_marker_for)	CAV1 BRD4	8.31e-04	33	38	2	DOID:1909 (is_marker_for)
Disease	Pulmonary Hypertension	BMPR2 BRD4	1.22e-03	40	38	2	C0020542
Disease	sex interaction measurement, inflammatory bowel disease	PSG1 EMSY	2.30e-03	55	38	2	EFO_0003767, EFO_0008343
Disease	Malignant neoplasm of breast	BMPR2 LIPE CAV1 GRIN2D SUV39H2 EMSY	2.33e-03	1074	38	6	C0006142

Protein segments in the cluster

Peptide	Gene	Start	Entry
TQQRKIGKTYPQQFP	ANKRD20A1	416	Q5TYW2
IPQPKYQIPKSANLI	C2orf16	136	Q68DN1
TQQRKIGKTYPQQFP	ANKRD20A8P	416	Q5CZ79
YLQQLQKVQPPTPLL	BRD4	931	O60885
TQQRKIGKTYPQQFP	ANKRD20A4P	416	Q4UJ75
VPIREQGNIYKPNNK	CAV1	16	Q03135
RRQIYGQNFIPPKQP	ATP2B3	81	Q16720
LSAPKQRVNVQKPPF	GORAB	66	Q5T7V8
TQQRKIGKTYPQQFP	ANKRD20A2P	416	Q5SQ80
YQIIVQPKTQKPNPA	DEPDC5	811	O75140
KLNKNIYSDIPPQVP	FAT1	4236	Q14517
QQQPTPVTPKKYPLR	KAT7	81	O95251
SPLLEVQLKPKNQPY	FRMD8P1	81	Q9BZ68
QNPKLQLKNSPPYIL	CBLB	61	Q13191
PNFQQPRPDKKRKYQ	MYH7B	606	A7E2Y1
FQQPPLLQQKLKYQP	KIF24	771	Q5T7B8
LLYPPNKELPQSKQF	DZIP3	451	Q86Y13
KPRQPNGIINQYRVK	PTPRQ	461	Q9UMZ3
FPNIKPYNNNRVKLI	PTPRQ	2066	Q9UMZ3
TQQRKIGKTYPQQFP	ANKRD20A3P	416	Q5VUR7
NIIRKNYIPNPDFVP	DNAH7	2766	Q8WXX0
QIYPLPKQQNLPKRP	BMPR2	741	Q13873
LQAYKPQNPKDAPVN	COL25A1-DT	51	Q6ZST2
PEYKPNLIQALKKQP	FOXN2	191	P32314
QNPKLALKNSPPYIL	CBL	71	P22681
PKLQQAPNQPKIYVQ	EMSY	1056	Q7Z589
NPVPQLRKFKTNVLP	POLR2M	241	P0CAP2
FVPNIQQTPKDKQPR	C4orf54	991	D6RIA3
LKLSPNKYQPIQPIQ	CEP295	651	Q9C0D2
QRPNLKYKPLPQISK	SACM1L	266	Q9NTJ5
LPKLPKPYITINNLN	PSG1	236	P11464
QKPAPQQSPYIQRVL	LIPE	91	Q05469
LPKLPKPYITINNLN	PSG3	236	Q16557
ARQKNQTPLPLIKPY	TAF9B	96	Q9HBM6
TYNQSIPQPPPRKIK	PWWP2A	281	Q96N64
IPKTQFLQPKQFPFL	POLR1A	1026	O95602
IKPQLQLYPPIKIFN	FER1L5	1991	A0AVI2
YKRLKVPPAINQFTQ	RPL7A	71	P62424
YFKRLIQIPQLPENP	HIP1	281	O00291
LPKLPKPYITINNLN	PSG7	236	Q13046
AYNKNQQIKIPPGTP	SUV39H2	211	Q9H5I1
RYTQFLQKPQKPIQP	TTC41P	11	Q6P2S7
SVKQQNEIFPKPPLY	ZNF518A	1081	Q6AHZ1
QKKVPYAKPIPAQFQ	WDR33	491	Q9C0J8
NQKKQYQLPSFPEPK	SIGLEC10	636	Q96LC7
RKFQRPQEQYPPLKF	GRIN2D	696	O15399