Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	myelin sheath abaxonal region	ITGB1 EXOC4	1.62e-04	9	45	2	GO:0035748
Domain	TRPM_tetra	TRPM1 TRPM3	3.55e-05	4	46	2	PF16519
Domain	TRPM_tetra	TRPM1 TRPM3	3.55e-05	4	46	2	IPR032415
Domain	Ion_trans_dom	TRPM1 TRPM3 SCN3A SCN7A	1.76e-04	114	46	4	IPR005821
Domain	Ion_trans	TRPM1 TRPM3 SCN3A SCN7A	1.76e-04	114	46	4	PF00520
Domain	Na_channel_asu	SCN3A SCN7A	2.64e-04	10	46	2	IPR001696
Domain	Na_trans_assoc	SCN3A SCN7A	2.64e-04	10	46	2	IPR010526
Domain	Na_trans_assoc	SCN3A SCN7A	2.64e-04	10	46	2	PF06512
Domain	C2	SYT15 CC2D2A ESYT2 CEP120	3.00e-04	131	46	4	PF00168
Domain	C2	SYT15 CC2D2A ESYT2 CEP120	3.56e-04	137	46	4	SM00239
Domain	C2_dom	SYT15 CC2D2A ESYT2 CEP120	7.02e-04	164	46	4	IPR000008
Domain	-	EEF1AKMT2 METTL15 COQ5	3.21e-03	120	46	3	3.40.50.150
Domain	SAM-dependent_MTases	EEF1AKMT2 METTL15 COQ5	3.36e-03	122	46	3	IPR029063
Domain	C2	SYT15 CC2D2A ESYT2	5.14e-03	142	46	3	PS50004
Domain	-	CC2D2A ESYT2 CEP120	5.77e-03	148	46	3	2.60.40.150
Domain	-	ZZEF1 TMPRSS6	7.28e-03	52	46	2	2.60.120.290
Domain	SCAN	ZNF75D ZSCAN23	8.40e-03	56	46	2	SM00431
Domain	Channel_four-helix_dom	SCN3A SCN7A	8.69e-03	57	46	2	IPR027359
Domain	-	SCN3A SCN7A	8.69e-03	57	46	2	1.20.120.350
Domain	CUB_dom	ZZEF1 TMPRSS6	8.69e-03	57	46	2	IPR000859
Domain	SCAN_BOX	ZNF75D ZSCAN23	8.99e-03	58	46	2	PS50804
Domain	SCAN	ZNF75D ZSCAN23	8.99e-03	58	46	2	PF02023
Domain	SCAN_dom	ZNF75D ZSCAN23	8.99e-03	58	46	2	IPR003309
Domain	Retrov_capsid_C	ZNF75D ZSCAN23	9.29e-03	59	46	2	IPR008916
Pubmed	Molecular interactions of ErbB1 (EGFR) and integrin-β1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance.	EGFR ITGB1	1.79e-06	2	47	2	23595626
Pubmed	β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells.	EGFR ITGB1	1.79e-06	2	47	2	21478906
Pubmed	Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites.	EGFR ITGB1	1.79e-06	2	47	2	14512423
Pubmed	Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.	TRPM1 TRPM3	1.79e-06	2	47	2	21278253
Pubmed	Bacterial Outer Membrane Protein OmpX Regulates β1 Integrin and Epidermal Growth Factor Receptor (EGFR) Involved in Invasion of M-HeLa Cells by Serratia proteamaculans.	EGFR ITGB1	1.79e-06	2	47	2	34948042
Pubmed	Update of genetic variants in CEP120 and CC2D2A-With an emphasis on genotype-phenotype correlations, tissue specific transcripts and exploring mutation specific exon skipping therapies.	CC2D2A CEP120	1.79e-06	2	47	2	33486889
Pubmed	Ubiquitin-specific protease 11 promotes partial epithelial-to-mesenchymal transition by deubiquitinating the epidermal growth factor receptor during kidney fibrosis.	EGFR USP11	1.79e-06	2	47	2	36581018
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	SLC35E1 ORC5 SMARCC2 SLC7A5 ESYT2 NCKAP1 ITGB1 ZMYM4 RRP12 EXOC4	3.81e-06	1203	47	10	29180619
Pubmed	Knockdown and knockout of β1-integrin in hepatocytes impairs liver regeneration through inhibition of growth factor signalling.	EGFR ITGB1	5.36e-06	3	47	2	24844558
Pubmed	Dominant Suppression of β1 Integrin by Ectopic CD98-ICD Inhibits Hepatocellular Carcinoma Progression.	SLC7A5 ITGB1	5.36e-06	3	47	2	27834933
Pubmed	A role for enhanced integrin and FAK expression in uremia-induced parathyroid hyperplasia.	EGFR ITGB1	5.36e-06	3	47	2	17514628
Pubmed	Notch, epidermal growth factor receptor, and beta1-integrin pathways are coordinated in neural stem cells.	EGFR ITGB1	5.36e-06	3	47	2	16332675
Pubmed	Lung cancer cells that survive ionizing radiation show increased integrin α2β1- and EGFR-dependent invasiveness.	EGFR ITGB1	5.36e-06	3	47	2	23951036
Pubmed	Identification of the minimal N-glycosylation on integrin α5β1 required for its inhibitory effect on EGFR signaling and cell proliferation.	EGFR ITGB1	5.36e-06	3	47	2	31858971
Pubmed	Human CMV infection of endothelial cells induces an angiogenic response through viral binding to EGF receptor and beta1 and beta3 integrins.	EGFR ITGB1	5.36e-06	3	47	2	18375753
Pubmed	Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation.	EGFR ITGB1	5.36e-06	3	47	2	17339338
Pubmed	Enterovirus 71 induces integrin β1/EGFR-Rac1-dependent oxidative stress in SK-N-SH cells: role of HO-1/CO in viral replication.	EGFR ITGB1	1.07e-05	4	47	2	21321939
Pubmed	Coordinate regulation of estrogen-mediated fibronectin matrix assembly and epidermal growth factor receptor transactivation by the G protein-coupled receptor, GPR30.	EGFR ITGB1	1.07e-05	4	47	2	19342448
Pubmed	Profound defects in pupillary responses to light in TRPM-channel null mice: a role for TRPM channels in non-image-forming photoreception.	TRPM1 TRPM3	1.07e-05	4	47	2	22211741
Pubmed	Platelet-Rich Plasma Promotes the Proliferation of Human Keratinocytes via a Progression of the Cell Cycle. A Role of Prolidase.	EGFR ITGB1	1.07e-05	4	47	2	33477820
Pubmed	CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion.	EGFR ITGB1	1.07e-05	4	47	2	26377974
Pubmed	Caveolin-1 contributes to anoikis resistance in human gastric cancer SGC-7901 cells via regulating Src-dependent EGFR-ITGB1 signaling.	EGFR ITGB1	1.07e-05	4	47	2	30088837
Pubmed	Epithelial-mesenchymal transition in cervical cancer: correlation with tumor progression, epidermal growth factor receptor overexpression, and snail up-regulation.	EGFR ITGB1	1.07e-05	4	47	2	18676743
Pubmed	Rab25 is involved in hypospadias via the β1 integrin/EGFR pathway.	EGFR ITGB1	1.07e-05	4	47	2	38401686
Pubmed	Immunohistochemical detection of EGFR, p185(erbB-2), Bcl-2 and p53 in breast carcinomas in pre-menopausal and post-menopausal women.	EIF3A EGFR	1.07e-05	4	47	2	18568671
Pubmed	Integrin-EGFR interaction regulates anoikis resistance in colon cancer cells.	EGFR ITGB1	1.07e-05	4	47	2	31641961
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	SLC35E1 ORC5 ESYT2 COG1 USP11 COQ5 RRP12	1.62e-05	606	47	7	36538041
Pubmed	Integrin alpha1beta1 regulates epidermal growth factor receptor activation by controlling peroxisome proliferator-activated receptor gamma-dependent caveolin-1 expression.	EGFR ITGB1	1.78e-05	5	47	2	20368353
Pubmed	Convergence of integrins and EGF receptor signaling via PI3K/Akt/FoxO pathway in early gene Egr-1 expression.	EGFR ITGB1	1.78e-05	5	47	2	18844239
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	SLC35E1 SLC7A5 ESYT2 EIF3A COG1 ITGB1 RSL1D1 CCNE2 RRP12 EXOC4	1.83e-05	1440	47	10	30833792
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	ORC5 SMARCC2 EIF3A CEP120 ASAH1 RSL1D1 ZMYM4 RRP12 EXOC4	2.08e-05	1155	47	9	20360068
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	SLC7A5 ESYT2 EGFR ITGB1 COQ5 EXOC4	2.14e-05	421	47	6	36976175
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	SLC7A5 ESYT2 PDPR EGFR ITGB1 RSL1D1 USP11 COQ5 RRP12 EXOC4	2.41e-05	1487	47	10	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	ESYT2 PDPR ZZEF1 METTL15 ITGB1 RSL1D1 USP11 COQ5 RRP12 EXOC4	2.54e-05	1496	47	10	32877691
Pubmed	Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the alpha6-integrin subunit.	EGFR ITGB1	2.67e-05	6	47	2	9022052
Pubmed	Integrated Proteomics-Based Physical and Functional Mapping of AXL Kinase Signaling Pathways and Inhibitors Define Its Role in Cell Migration.	ESYT2 EGFR ITGB1	3.37e-05	46	47	3	35022314
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	SLC35E1 SLC7A5 ESYT2 EGFR ITGB1 EXOC4	3.82e-05	467	47	6	30194290
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	EIF3A EGFR RSL1D1 RRP12	4.38e-05	144	47	4	35681168
Pubmed	Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the α3β1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT α6β4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.	EGFR ITGB1	4.98e-05	8	47	2	26350464
Pubmed	Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival.	EGFR ITGB1	4.98e-05	8	47	2	25202019
Pubmed	A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs.	NCKAP1 EGFR	4.98e-05	8	47	2	9344857
Pubmed	A kinase-independent role for EGF receptor in autophagy initiation.	EGFR EXOC4	4.98e-05	8	47	2	25594178
Pubmed	Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse.	NCKAP1 NODAL	4.98e-05	8	47	2	20689803
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	EIF3A ITGB1 ZSCAN23 RSL1D1 USP11 ZMYM4	5.40e-05	497	47	6	23414517
Pubmed	Claudin-4 localization in epithelial ovarian cancer.	SLC7A5 EGFR ITGB1	5.47e-05	54	47	3	36237976
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	CC2D2A COG1 UNC79 SCN3A	5.54e-05	153	47	4	10718198
Pubmed	Harnessing host enhancers of SARS-CoV-2 entry as novel targets for antiviral therapy.	SLC7A5 EGFR ITGB1	5.78e-05	55	47	3	38945485
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	SMARCC2 SLC7A5 ESYT2 EGFR RSL1D1 ZMYM4 RRP12	7.63e-05	774	47	7	15302935
Pubmed	The N6-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2.	SLC7A5 EIF3A NCKAP1 EGFR EXOC4	7.68e-05	325	47	5	36168628
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	SLC7A5 ESYT2 EIF3A PDPR NCKAP1 ITGB1 ASAH1 RSL1D1 RRP12	7.71e-05	1367	47	9	32687490
Pubmed	Cancer-associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7.	EIF3A EGFR ITGB1 RRP12	9.33e-05	175	47	4	37866880
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	ORC5 ESYT2 CEP120 NCKAP1 USP11 EXOC4	1.04e-04	560	47	6	35241646
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	SLC35E1 SLC7A5 ESYT2 EGFR ITGB1 EXOC4	1.12e-04	568	47	6	37774976
Pubmed	Dynamic expression of the TRPM subgroup of ion channels in developing mouse sensory neurons.	TRPM1 TRPM3	1.17e-04	12	47	2	19850157
Pubmed	Genomic analysis of synaptotagmin genes.	SYT15 ESYT2	1.38e-04	13	47	2	11543631
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	ORC5 SMARCC2 ESYT2 NCKAP1 ITGB1 USP11 ZMYM4	1.43e-04	857	47	7	25609649
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	ESYT2 EIF3A ITGB1 RSL1D1 RRP12	1.50e-04	375	47	5	32788342
Pubmed	MicroRNA profile of the developing mouse retina.	TRPM1 TRPM3	1.61e-04	14	47	2	19933188
Pubmed	Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves.	ITGB1 EXOC4	1.86e-04	15	47	2	20237282
Pubmed	Redundant role of protein kinase C delta and epsilon during mouse embryonic development.	ITGB1 CCNE2	1.86e-04	15	47	2	25084151
Pubmed	Confirmation of quantitative trait loci for alcohol preference in mice.	SCN3A SCN7A	1.86e-04	15	47	2	9726281
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	SMARCC2 TRPM1 PDPR RSL1D1 RRP12	1.93e-04	396	47	5	26687479
Pubmed	Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.	NCKAP1 ITGB1	2.12e-04	16	47	2	21945075
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	SMARCC2 ESYT2 EIF3A EGFR ITGB1 EXOC4	2.27e-04	647	47	6	26618866
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	EEF1AKMT2 EIF3A NODAL ITGB1 RRP12	2.40e-04	415	47	5	16385451
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	SLC7A5 ESYT2 EIF3A ZZEF1 ITGB1 EXOC4	2.47e-04	657	47	6	36180527
Pubmed	Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly.	SLC7A5 EGFR ITGB1	2.76e-04	93	47	3	38245532
Pubmed	Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population.	CYP2S1 CES1	3.01e-04	19	47	2	12721789
Pubmed	CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity.	EGFR ITGB1	3.34e-04	20	47	2	19726564
Pubmed	Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.	EIF3A EGFR	3.69e-04	21	47	2	1676978
Pubmed	Loss of Sip1 leads to migration defects and retention of ectodermal markers during lens development.	NCKAP1 EGFR	3.69e-04	21	47	2	24161570
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	EIF3A RSL1D1 ZMYM4 RRP12	4.35e-04	262	47	4	36880596
Pubmed	Mapping the expression of transient receptor potential channels across murine placental development.	TRPM1 TRPM3	4.84e-04	24	47	2	33884443
Pubmed	Rab7-Mediated Endocytosis Establishes Patterning of Wnt Activity through Inactivation of Dkk Antagonism.	NODAL ITGB1	4.84e-04	24	47	2	32521258
Pubmed	Rac1 mediates morphogenetic responses to intercellular signals in the gastrulating mouse embryo.	NCKAP1 NODAL	4.84e-04	24	47	2	21693517
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	SMARCC2 EIF3A RSL1D1 USP11 RRP12	4.94e-04	486	47	5	30940648
Pubmed	International Union of Pharmacology. XLIX. Nomenclature and structure-function relationships of transient receptor potential channels.	TRPM1 TRPM3	5.26e-04	25	47	2	16382100
Pubmed	Genetic ablation of FLRT3 reveals a novel morphogenetic function for the anterior visceral endoderm in suppressing mesoderm differentiation.	NODAL ITGB1	5.26e-04	25	47	2	19056886
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	SMARCC2 SLC7A5 EIF3A NCKAP1 EGFR ITGB1 RSL1D1 RRP12	5.62e-04	1415	47	8	28515276
Pubmed	An introduction to TRP channels.	TRPM1 TRPM3	6.14e-04	27	47	2	16460286
Pubmed	EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition.	NODAL ITGB1	7.09e-04	29	47	2	18794329
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	ASAH1 RSL1D1 USP11 RRP12	7.23e-04	300	47	4	28561026
Pubmed	Self-assembling protein microarrays.	ORC5 CCNE2	7.59e-04	30	47	2	15232106
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	EIF3A NCKAP1 EGFR EXOC4	7.59e-04	304	47	4	32235678
Pubmed	Human chromosome 7: DNA sequence and biology.	GALNTL5 ORC5 ESYT2 AGMO EXOC4	7.68e-04	536	47	5	12690205
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NLRC5 ESYT2 EGFR METTL15 ITGB1 ZMYM4 TMPRSS6 EXOC4	7.85e-04	1489	47	8	28611215
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SLC35E1 ORC5 SLC7A5 ESYT2 EIF3A NCKAP1 ZMYM4 RRP12	8.13e-04	1497	47	8	31527615
Pubmed	mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin.	SLC7A5 EIF3A RRP12 EXOC4	8.36e-04	312	47	4	37120454
Pubmed	A quantitative analysis of the spatiotemporal pattern of transient receptor potential gene expression in the developing mouse cochlea.	TRPM1 TRPM3	9.19e-04	33	47	2	19834762
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	SMARCC2 SLC7A5 EIF3A RSL1D1 ZMYM4 RRP12	9.40e-04	847	47	6	35850772
Pubmed	Joubert Syndrome	CC2D2A CEP120	9.75e-04	34	47	2	20301500
Pubmed	The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.	EGFR CES1	9.75e-04	34	47	2	1686571
Pubmed	Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.	C16orf96 EIF3A ITGB1 USP11 RRP12	1.03e-03	573	47	5	28330616
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	SLC35E1 SLC7A5 EIF3A ZZEF1 EGFR ITGB1 RRP12	1.08e-03	1201	47	7	35696571
Pubmed	LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression.	EIF3A NCKAP1 EGFR RSL1D1 RRP12	1.09e-03	580	47	5	35676659
Pubmed	Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC.	SLC7A5 EGFR	1.09e-03	36	47	2	16097034
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	ORC5 ZMYM4 RRP12	1.11e-03	150	47	3	30154076
Pubmed	Proximity labelling identifies pro-migratory endocytic recycling cargo and machinery of the Rab4 and Rab11 families.	SLC7A5 EGFR ITGB1 EXOC4	1.14e-03	339	47	4	37232246
Pubmed	Transcription Factor CTIP1/ BCL11A Regulates Epidermal Differentiation and Lipid Metabolism During Skin Development.	EGFR ASAH1	1.16e-03	37	47	2	29044125
Pubmed	A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition.	CC2D2A NODAL	1.16e-03	37	47	2	21725307
GeneFamily	Transient receptor potential cation channels	TRPM1 TRPM3	1.19e-03	28	33	2	249
GeneFamily	Methyltransferase like	EEF1AKMT2 METTL15	1.65e-03	33	33	2	963
ToppCell	facs-Brain_Non-Myeloid-Striatum_-18m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf96 EGFR TRPM3 TMPRSS6	2.97e-05	172	46	4	e15ab284df6dd241d4481f98864b18c39d757b8c
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	GALNTL5 ITGB1 CES1 AGMO	4.11e-05	187	46	4	8c69fd469df2915c56ede534cee3ef23d5f64ebf
ToppCell	ASK454-Endothelial-Lymphatic\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	NLRC5 EEF1AKMT2 CEP120 ZZEF1	4.29e-05	189	46	4	316c857dec9383823e09f966bca62d52d933b141
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5-_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CC2D2A ITGB1 RSL1D1 TMPRSS6	4.38e-05	190	46	4	36e83995021ba16690f84e2077a9e8baec547d05
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-epithelial_cell_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CC2D2A ITGB1 RSL1D1 TMPRSS6	4.38e-05	190	46	4	d26be9e1b676f750e716b91ebc3598fac3735612
ToppCell	facs-Lung-nan-3m-Epithelial-Ciliated_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf96 CYP2S1 TRPM3 RGS22	4.38e-05	190	46	4	e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCell	facs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	C16orf96 CYP2S1 TRPM3 RGS22	4.38e-05	190	46	4	fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCell	myeloid-Dendritic_cell-Conventional_dendritic_cell\|World / Lineage, cell class and subclass	SLC7A5 CYP2S1 CES1 ASAH1	5.14e-05	198	46	4	2ec42643200aa9feb33e2b87570f276fbad21cad
ToppCell	myeloid-Dendritic_cell\|World / Lineage, cell class and subclass	SLC7A5 CYP2S1 CES1 ASAH1	5.14e-05	198	46	4	240fff8264caeb7d1efcbccb187fe93744559bbc
ToppCell	control\|World / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CYP2S1 NCKAP1 EGFR CES1	5.34e-05	200	46	4	97f36d2c197e03d93a1fc59949d77ae90f6e6a9a
ToppCell	NS-control\|NS / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CYP2S1 NCKAP1 EGFR CES1	5.34e-05	200	46	4	ecbe89ff95d046155b984c8c150e0b9e7278f839
Disease	MASA syndrome (implicated_via_orthology)	TRPM1 TRPM3	4.75e-05	7	45	2	DOID:0060246 (implicated_via_orthology)
Disease	Intellectual Disability	SMARCC2 TRPM3 ASAH1 COQ5 SCN3A AGMO	5.77e-05	447	45	6	C3714756
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN3A SCN7A	1.02e-04	10	45	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN3A SCN7A	1.02e-04	10	45	2	DOID:0080422 (implicated_via_orthology)
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN3A SCN7A	1.49e-04	12	45	2	DOID:0060170 (implicated_via_orthology)
Disease	anxiety disorder (implicated_via_orthology)	NODAL SCN3A	5.15e-04	22	45	2	DOID:2030 (implicated_via_orthology)
Disease	hepatocellular carcinoma (is_marker_for)	NLRC5 SLC7A5 EGFR CES1	1.14e-03	301	45	4	DOID:684 (is_marker_for)
Disease	sleep apnea	CEP120 METTL15	1.71e-03	40	45	2	EFO_0003877
Disease	colorectal cancer (is_marker_for)	SLC7A5 EGFR CES1	1.78e-03	157	45	3	DOID:9256 (is_marker_for)
Disease	Endometrioma	EGFR ITGB1 CCNE2	1.91e-03	161	45	3	C0269102
Disease	Endometriosis	EGFR ITGB1 CCNE2	1.91e-03	161	45	3	C0014175
Disease	high grade glioma (implicated_via_orthology)	SLC7A5 EGFR	2.07e-03	44	45	2	DOID:3070 (implicated_via_orthology)
Disease	lung non-small cell carcinoma (is_marker_for)	SLC7A5 EGFR ITGB1	2.20e-03	169	45	3	DOID:3908 (is_marker_for)
Disease	Cardiomyopathy, Dilated	EGFR ITGB1	2.45e-03	48	45	2	C0007193
Disease	Cardiomyopathy, Familial Idiopathic	EGFR ITGB1	2.66e-03	50	45	2	C1449563
Disease	Squamous cell carcinoma of the head and neck	EGFR CCNE2	2.87e-03	52	45	2	C1168401

Protein segments in the cluster

Peptide	Gene	Start	Entry
DLTKKNRLPVMVWIH	CES1	126	P23141
KGKLHLRLEWLTLMP	ESYT2	496	A0FGR8
ERKRILPTWMLAEHL	APLF	181	Q8IW19
MLLELVVSWILKGKP	AGMO	51	Q6ZNB7
MELIILKALKWELCP	CCNE2	226	O96020
RWHELMLDKAPVLKV	ASAH1	61	Q13510
ALLLIWKLLMIIHDR	ITGB1	746	P05556
LLLMKYPHVQKWVRE	CYP2S1	316	Q96SQ9
WLKKHMPKDSNLLLE	PDPR	601	Q8NCN5
AIIGMIWLRHRKPEL	SLC7A5	411	Q01650
APLMWELIHKKVLSP	METTL15	371	A6NJ78
LEGKWMLKRLDLSHL	NLRC5	1546	Q86WI3
EIIWLLRHADNMPKK	NCKAP1	381	Q9Y2A7
WRLREMKPLLEQLLK	FAM9A	296	Q8IZU1
VPIKWMALESILHRI	EGFR	876	P00533
KMLLHCKRDELRKLW	EXOC4	101	Q96A65
EKILKEKIMDWRPRH	CC2D2A	1501	Q9P2K1
IKLLLEIPEKIWSSM	COG1	121	Q8WTW3
RPVQDLWHLIKLRKM	C16orf96	116	A6NNT2
RTWQKIHEPIMLKYL	EIF3A	41	Q14152
LRIPLLVELWHKDKM	CEP120	526	Q8N960
NRLIRWMQKHKIPLD	EEF1AKMT2	66	Q5JPI9
WLEPLLHAIAKDPKM	GALNTL5	236	Q7Z4T8
HRVWKDLLLWKMHPL	COQ5	91	Q5HYK3
MLSKPKELVKRWHAL	SYT15	401	Q9BQS2
MVLEVTRPLSKWLKH	NODAL	151	Q96S42
ILLLLLEPWTKMVKS	RGS22	766	Q8NE09
RKLWRNIEPHLKKAM	ORC5	251	O43913
PHDLRWLLELLMGDK	ST3GAL6	191	Q9Y274
WLKVKHLVNLIVMDP	SCN3A	746	Q9NY46
PIWVVLLSRIIMKEK	SLC35E1	146	Q96K37
VRPVMKRDKQVLLHW	SMARCC2	191	Q8TAQ2
PLLAWLKVMEKAHIN	RRP12	386	Q5JTH9
RHPLFIWLKMRISKL	TAS2R1	111	Q9NYW7
LMVVLWKIPSKELRV	RSL1D1	66	O76021
DTKPDLLLHLMTKEW	TRPM3	161	Q9HCF6
VDDLLLWKKIHRMVI	TTLL2	336	Q9BWV7
HLMVKDWQLELPKLL	TRPM1	86	Q7Z4N2
RIKHWKMASKLILPE	ZNF75D	216	P51815
HWIRLKMKPDVVLRH	ZZEF1	286	O43149
WLKLKEFVHRIIMAP	SCN7A	491	Q01118
WATAIPRLEKLKLML	WHAMMP3	56	Q1A5X7
ATKKLDLWMLPEILI	USP11	811	P51784
DLWMLPEILIIHLKR	USP11	816	P51784
MIELTKLLKIWEPTI	ZMYM4	1336	Q5VZL5
LWHLQGPKDLMLKLR	TMPRSS6	246	Q8IU80
KPHIRQMWLKALLVI	UNC79	1391	Q9P2D8
WLRPEMHTKEQILEL	ZSCAN23	76	Q3MJ62