Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	microtubule-based process	ADCY10 SLC9C1 DST CCDC42 CCNB2 CEP290 KIF16B SASS6 HAUS3 APOB APP CCDC65 DNAH9 TRIM37 TBCE DNAH11	7.81e-06	1058	87	16	GO:0007017
GeneOntologyBiologicalProcess	multicellular organismal reproductive process	TGFB2 ADCY10 PARP1 SLC9C1 CCDC42 CCNB2 LRRK2 LRRC8A ACSBG2 APOB HERC2 APP HSF1 TDRD1 TRIP13 LARP7 SLC4A2	8.61e-06	1194	87	17	GO:0048609
GeneOntologyBiologicalProcess	inclusion body assembly	SNCAIP SACS HSF1 TRIM37	1.10e-05	33	87	4	GO:0070841
GeneOntologyBiologicalProcess	spermatogenesis	ADCY10 SLC9C1 CCDC42 LRRK2 LRRC8A ACSBG2 APOB HERC2 HSF1 TDRD1 TRIP13 LARP7 SLC4A2	1.38e-05	744	87	13	GO:0007283
GeneOntologyBiologicalProcess	male gamete generation	ADCY10 SLC9C1 CCDC42 LRRK2 LRRC8A ACSBG2 APOB HERC2 HSF1 TDRD1 TRIP13 LARP7 SLC4A2	1.77e-05	762	87	13	GO:0048232
GeneOntologyBiologicalProcess	positive regulation of protein localization	TGFB2 GRIP1 ADCY10 PARP1 ATP2C1 TCP1 CEP290 LRRC8A APP HCFC1 LARP7	3.80e-05	591	87	11	GO:1903829
GeneOntologyBiologicalProcess	smooth endoplasmic reticulum calcium ion homeostasis	APP DMTN	5.26e-05	3	87	2	GO:0051563
GeneOntologyBiologicalProcess	gamete generation	ADCY10 SLC9C1 CCDC42 CCNB2 LRRK2 LRRC8A ACSBG2 APOB HERC2 HSF1 TDRD1 TRIP13 LARP7 SLC4A2	5.90e-05	982	87	14	GO:0007276
GeneOntologyBiologicalProcess	regulation of mitochondrial membrane potential	ADCY10 PARP1 LRRK2 SPART PID1	6.53e-05	100	87	5	GO:0051881
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 SLC34A1 LRRK2 LRRC8A PLCB2 APP HCFC1 RYR2 DMTN SLC4A2	6.64e-05	866	87	13	GO:0055082
GeneOntologyBiologicalProcess	regulation of inclusion body assembly	SNCAIP SACS HSF1	9.12e-05	21	87	3	GO:0090083
GeneOntologyBiologicalProcess	negative regulation of ATP biosynthetic process	PARP1 PID1	1.05e-04	4	87	2	GO:2001170
GeneOntologyBiologicalProcess	sexual reproduction	ADCY10 SLC9C1 CCDC42 TCP1 CCNB2 LRRK2 LRRC8A ACSBG2 APOB HERC2 HSF1 TDRD1 TRIP13 LARP7 ANAPC4 SLC4A2	1.06e-04	1312	87	16	GO:0019953
GeneOntologyBiologicalProcess	regulation of organelle organization	TGFB2 ADCY10 PARP1 TCP1 SIPA1L1 LRRK2 SASS6 HAUS3 LIMCH1 HSF1 TRIP13 PID1 TRIM37 DMTN ANAPC4 SLC4A2	1.38e-04	1342	87	16	GO:0033043
GeneOntologyBiologicalProcess	regulation of protein localization	TGFB2 GRIP1 ADCY10 PARP1 ATP2C1 TCP1 CEP290 LRRK2 LRRC8A APP HCFC1 PID1 LARP7 DMTN	1.73e-04	1087	87	14	GO:0032880
GeneOntologyBiologicalProcess	negative regulation of purine nucleotide biosynthetic process	PARP1 PID1	1.74e-04	5	87	2	GO:1900372
GeneOntologyBiologicalProcess	negative regulation of nucleotide biosynthetic process	PARP1 PID1	1.74e-04	5	87	2	GO:0030809
GeneOntologyBiologicalProcess	collateral sprouting in absence of injury	SPART APP	1.74e-04	5	87	2	GO:0048669
GeneOntologyBiologicalProcess	regulation of ATP biosynthetic process	ADCY10 PARP1 PID1	1.76e-04	26	87	3	GO:2001169
GeneOntologyBiologicalProcess	monoatomic cation homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 SLC34A1 LRRK2 PLCB2 APP RYR2 DMTN SLC4A2	1.82e-04	705	87	11	GO:0055080
GeneOntologyBiologicalProcess	developmental process involved in reproduction	TGFB2 ADCY10 PARP1 SLC9C1 CCDC42 LRRK2 LRRC8A ACSBG2 APOB HERC2 HSF1 TDRD1 TRIP13 LARP7 SLC4A2	1.88e-04	1235	87	15	GO:0003006
GeneOntologyBiologicalProcess	regulation of mitochondrial depolarization	ADCY10 PARP1 LRRK2	1.97e-04	27	87	3	GO:0051900
GeneOntologyBiologicalProcess	monoatomic ion homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 SLC34A1 LRRK2 PLCB2 APP RYR2 DMTN SLC4A2	2.10e-04	717	87	11	GO:0050801
GeneOntologyBiologicalProcess	cellular homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 SLC34A1 LRRK2 LRRC8A PLCB2 APP HCFC1 RYR2 DMTN SLC4A2	2.29e-04	981	87	13	GO:0019725
GeneOntologyBiologicalProcess	microtubule-based movement	ADCY10 SLC9C1 DST KIF16B APOB APP CCDC65 DNAH9 DNAH11	2.33e-04	493	87	9	GO:0007018
GeneOntologyBiologicalProcess	calcium ion homeostasis	TGFB2 IBTK ATP2C1 SLC34A1 PLCB2 APP RYR2 DMTN	2.38e-04	389	87	8	GO:0055074
GeneOntologyBiologicalProcess	intracellular monoatomic cation homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 LRRK2 PLCB2 APP RYR2 DMTN SLC4A2	2.49e-04	611	87	10	GO:0030003
GeneOntologyBiologicalProcess	positive regulation of ATPase-coupled calcium transmembrane transporter activity	VMP1 RYR2	2.61e-04	6	87	2	GO:1901896
GeneOntologyBiologicalProcess	intracellular monoatomic ion homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 LRRK2 PLCB2 APP RYR2 DMTN SLC4A2	2.87e-04	622	87	10	GO:0006873
GeneOntologyBiologicalProcess	nucleotide transmembrane transport	ADCY10 LRRC8A LRRC8B	2.99e-04	31	87	3	GO:1901679
GeneOntologyBiologicalProcess	positive regulation of establishment of protein localization	TGFB2 ADCY10 ATP2C1 TCP1 CEP290 LRRC8A APP HCFC1	3.01e-04	403	87	8	GO:1904951
GeneOntologyBiologicalProcess	positive regulation of cell cycle	TGFB2 SASS6 APP HSF1 SPDYE2B HCFC1 SPDYE6 LARP7	3.22e-04	407	87	8	GO:0045787
GeneOntologyBiologicalProcess	response to metal ion	PARP1 SLC34A1 LRRK2 GATM APP HSF1 RYR2 DMTN	3.67e-04	415	87	8	GO:0010038
GeneOntologyBiologicalProcess	mitochondrial depolarization	ADCY10 PARP1 LRRK2	4.30e-04	35	87	3	GO:0051882
GeneOntologyBiologicalProcess	cyclic-GMP-AMP transmembrane import across plasma membrane	LRRC8A LRRC8B	4.84e-04	8	87	2	GO:0140361
GeneOntologyBiologicalProcess	regulation of cellular localization	TGFB2 GRIP1 ADCY10 PARP1 ATP2C1 TCP1 CEP290 LRRK2 LRRC8A APP HCFC1 PID1 LARP7 DMTN	5.22e-04	1212	87	14	GO:0060341
GeneOntologyBiologicalProcess	regulation of establishment of protein localization	TGFB2 ADCY10 ATP2C1 TCP1 CEP290 LRRK2 LRRC8A APP HCFC1 DMTN	5.39e-04	674	87	10	GO:0070201
GeneOntologyBiologicalProcess	regulation of ATP metabolic process	ADCY10 PARP1 APP PID1	5.97e-04	91	87	4	GO:1903578
GeneOntologyBiologicalProcess	regulation of purine nucleotide biosynthetic process	ADCY10 PARP1 PID1	6.40e-04	40	87	3	GO:1900371
GeneOntologyBiologicalProcess	purine-containing compound transmembrane transport	ADCY10 LRRC8A LRRC8B	6.40e-04	40	87	3	GO:0072530
GeneOntologyBiologicalProcess	regulation of nucleotide biosynthetic process	ADCY10 PARP1 PID1	6.40e-04	40	87	3	GO:0030808
GeneOntologyBiologicalProcess	purine ribonucleotide transport	ADCY10 LRRC8A LRRC8B	6.40e-04	40	87	3	GO:0015868
GeneOntologyBiologicalProcess	chemical homeostasis	TGFB2 IBTK SLC9C1 ATP2C1 SLC34A1 LRRK2 LRRC8A APOB PLCB2 APP HCFC1 RYR2 DMTN SLC4A2	7.03e-04	1249	87	14	GO:0048878
GeneOntologyBiologicalProcess	adenine nucleotide transport	ADCY10 LRRC8A LRRC8B	7.39e-04	42	87	3	GO:0051503
GeneOntologyBiologicalProcess	guanine nucleotide transmembrane transport	LRRC8A LRRC8B	7.74e-04	10	87	2	GO:1903790
GeneOntologyBiologicalProcess	intracellular calcium ion homeostasis	TGFB2 IBTK ATP2C1 PLCB2 APP RYR2 DMTN	8.09e-04	359	87	7	GO:0006874
GeneOntologyBiologicalProcess	cilium movement	ADCY10 SLC9C1 APOB CCDC65 DNAH9 DNAH11	8.31e-04	261	87	6	GO:0003341
GeneOntologyBiologicalProcess	purine nucleotide transport	ADCY10 LRRC8A LRRC8B	8.47e-04	44	87	3	GO:0015865
GeneOntologyBiologicalProcess	regulation of protein phosphorylation	TGFB2 ADCY10 IBTK CCNB2 LRRK2 LIMCH1 APP HSF1 SPDYE2B PID1 WDR59 SPDYE6 DMTN	8.97e-04	1133	87	13	GO:0001932
GeneOntologyBiologicalProcess	regulation of protein localization to nucleus	TGFB2 PARP1 TCP1 APP LARP7	8.98e-04	176	87	5	GO:1900180
GeneOntologyBiologicalProcess	tubulin complex assembly	TCP1 TBCE	9.44e-04	11	87	2	GO:0007021
GeneOntologyBiologicalProcess	cyclic nucleotide transport	LRRC8A LRRC8B	9.44e-04	11	87	2	GO:0070729
GeneOntologyBiologicalProcess	guanine nucleotide transport	LRRC8A LRRC8B	9.44e-04	11	87	2	GO:0001408
GeneOntologyBiologicalProcess	regulation of protein localization to Cajal body	TCP1 LARP7	9.44e-04	11	87	2	GO:1904869
GeneOntologyBiologicalProcess	positive regulation of protein localization to Cajal body	TCP1 LARP7	9.44e-04	11	87	2	GO:1904871
GeneOntologyCellularComponent	smooth endoplasmic reticulum	APOB APP RYR2 DMTN	4.00e-05	46	87	4	GO:0005790
GeneOntologyCellularComponent	intermediate-density lipoprotein particle	APOB APP	2.54e-04	6	87	2	GO:0034363
GeneOntologyCellularComponent	trans-Golgi network	TGFB2 ATP2C1 RAB43 LRRK2 TBC1D23 APP ECPAS	2.89e-04	306	87	7	GO:0005802
Domain	LRRC8_Pannexin-like	LRRC8A LRRC8B	2.13e-04	5	87	2	IPR021040
Domain	Pannexin_like	LRRC8A LRRC8B	2.13e-04	5	87	2	PF12534
Domain	PDZ	GRIP1 SIPA1L1 MPDZ PDZD7 PDZD4	5.14e-04	141	87	5	PF00595
Domain	DHC_N1	DNAH9 DNAH11	5.90e-04	8	87	2	PF08385
Domain	Dynein_heavy_dom-1	DNAH9 DNAH11	5.90e-04	8	87	2	IPR013594
Domain	PDZ	GRIP1 SIPA1L1 MPDZ PDZD7 PDZD4	6.40e-04	148	87	5	SM00228
Domain	-	GRIP1 SIPA1L1 MPDZ PDZD7 PDZD4	6.80e-04	150	87	5	2.30.42.10
Domain	PDZ	GRIP1 SIPA1L1 MPDZ PDZD7 PDZD4	7.01e-04	151	87	5	PS50106
Domain	PDZ	GRIP1 SIPA1L1 MPDZ PDZD7 PDZD4	7.22e-04	152	87	5	IPR001478
Domain	-	ANKRD36B IBTK SNCAIP LRRK2 ANKRD30B ANKRD36	1.06e-03	248	87	6	1.25.40.20
Domain	Spy1	SPDYE2B SPDYE6	1.15e-03	11	87	2	PF11357
Domain	Speedy	SPDYE2B SPDYE6	1.15e-03	11	87	2	IPR020984
Domain	Ankyrin_rpt-contain_dom	ANKRD36B IBTK SNCAIP LRRK2 ANKRD30B ANKRD36	1.20e-03	254	87	6	IPR020683
Domain	Ankyrin_rpt	ANKRD36B IBTK SNCAIP LRRK2 ANKRD30B ANKRD36	1.41e-03	262	87	6	IPR002110
Domain	Dynein_heavy_chain_D4_dom	DNAH9 DNAH11	1.88e-03	14	87	2	IPR024317
Domain	Dynein_HC_stalk	DNAH9 DNAH11	1.88e-03	14	87	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH9 DNAH11	1.88e-03	14	87	2	IPR013602
Domain	DHC_N2	DNAH9 DNAH11	1.88e-03	14	87	2	PF08393
Domain	MT	DNAH9 DNAH11	1.88e-03	14	87	2	PF12777
Domain	AAA_8	DNAH9 DNAH11	1.88e-03	14	87	2	PF12780
Domain	ATPase_dyneun-rel_AAA	DNAH9 DNAH11	1.88e-03	14	87	2	IPR011704
Domain	AAA_5	DNAH9 DNAH11	1.88e-03	14	87	2	PF07728
Domain	DHC_fam	DNAH9 DNAH11	2.17e-03	15	87	2	IPR026983
Domain	Dynein_heavy_dom	DNAH9 DNAH11	2.17e-03	15	87	2	IPR004273
Domain	Dynein_heavy	DNAH9 DNAH11	2.17e-03	15	87	2	PF03028
Domain	Ank_2	ANKRD36B IBTK SNCAIP ANKRD30B ANKRD36	3.32e-03	215	87	5	PF12796
Domain	CH	DST MICAL2 LIMCH1	3.46e-03	65	87	3	SM00033
Domain	RCC1	IBTK HERC2	3.86e-03	20	87	2	PF00415
Domain	RCC1_1	IBTK HERC2	4.25e-03	21	87	2	PS00625
Domain	RCC1_2	IBTK HERC2	4.25e-03	21	87	2	PS00626
Domain	RCC1_3	IBTK HERC2	4.25e-03	21	87	2	PS50012
Domain	Ank	ANKRD36B IBTK SNCAIP ANKRD30B ANKRD36	4.26e-03	228	87	5	PF00023
Domain	CH	DST MICAL2 LIMCH1	4.27e-03	70	87	3	PF00307
Domain	-	DST MICAL2 LIMCH1	4.44e-03	71	87	3	1.10.418.10
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	GRIP1 TTF2 IBTK TCP1 CCNB2 SIPA1L1 CEP290 SASS6 HAUS3 HERC2 TBC1D23 ECPAS TRIM37 TBCE	4.13e-08	853	90	14	28718761
Pubmed	A protein interaction landscape of breast cancer.	PARP1 AP2S1 ATP2C1 DST MICAL2 CCNB2 PUM3 ECPAS MRPS22 LARP7 ANAPC4	7.66e-07	634	90	11	34591612
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	DST TCP1 CCDC168 DNAH9 HCFC1 RYR2	8.45e-07	123	90	6	26912792
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TET2 PARP1 ITCH DST SACS MICAL2 SIPA1L1 CEP290 GATM ANKRD36 HERC2 TBC1D23 APP WDR59 TRIM37	1.02e-06	1285	90	15	35914814
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	ANKRD36B IBTK PARP1 REXO4 AP2S1 AUH TCP1 RAB43 LRRC8A PUM3 APOB LIMCH1 HERC2 HCFC1 LARP7	2.28e-06	1371	90	15	36244648
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	AUH TCP1 SIPA1L1 LRRC8A MPDZ LRRC8B LIMCH1 HERC2 LARP7	4.07e-06	475	90	9	31040226
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	GRIP1 PARP1 AP2S1 DST SACS GATM IDH3B ECPAS HCFC1	5.96e-06	498	90	9	36634849
Pubmed	Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein.	TGFB2 APP	6.62e-06	2	90	2	16227582
Pubmed	Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.	LRRK2 APP	6.62e-06	2	90	2	28720718
Pubmed	Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH.	ITCH SPART	6.62e-06	2	90	2	38503285
Pubmed	Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer's disease.	APP HPSE	6.62e-06	2	90	2	33971986
Pubmed	Early-stage epigenetic modification during somatic cell reprogramming by Parp1 and Tet2.	TET2 PARP1	6.62e-06	2	90	2	22902501
Pubmed	Undetectable histone O-GlcNAcylation in mammalian cells.	TET2 HCFC1	6.62e-06	2	90	2	26075789
Pubmed	Amyloid-beta colocalizes with apolipoprotein B in absorptive cells of the small intestine.	APOB APP	6.62e-06	2	90	2	19845970
Pubmed	Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.	TRIP13 PLIN2	6.62e-06	2	90	2	36031387
Pubmed	A sperm-specific Na+/H+ exchanger (sNHE) is critical for expression and in vivo bicarbonate regulation of the soluble adenylyl cyclase (sAC).	ADCY10 SLC9C1	6.62e-06	2	90	2	17517652
Pubmed	Limiting RyR2 Open Time Prevents Alzheimer's Disease-Related Neuronal Hyperactivity and Memory Loss but Not β-Amyloid Accumulation.	APP RYR2	6.62e-06	2	90	2	32966798
Pubmed	Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1.	GRIP1 FRAS1	6.62e-06	2	90	2	18155042
Pubmed	hPuf-A/KIAA0020 modulates PARP-1 cleavage upon genotoxic stress.	PARP1 PUM3	6.62e-06	2	90	2	21266351
Pubmed	Poly(ADP-Ribose) Polymerase 1 Promotes the Human Heat Shock Response by Facilitating Heat Shock Transcription Factor 1 Binding to DNA.	PARP1 HSF1	6.62e-06	2	90	2	29661921
Pubmed	Overexpression of heparanase lowers the amyloid burden in amyloid-β precursor protein transgenic mice.	APP HPSE	6.62e-06	2	90	2	25548284
Pubmed	Exome sequencing: an efficient diagnostic tool for complex neurodegenerative disorders.	SACS APOB	6.62e-06	2	90	2	23043354
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	PARP1 FRAS1 DST TCP1 RAB43 LRRK2 APOB HERC2 HCFC1	7.55e-06	513	90	9	25798074
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	FMNL3 FRAS1 DST TCP1 SIPA1L1 PUM3 HCFC1 MRPS22	1.16e-05	410	90	8	26949251
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	GRIP1 TTF2 PARP1 DST TCP1 SPART MPDZ ECPAS HCFC1 TBCE	1.52e-05	708	90	10	39231216
Pubmed	Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.	TGFB2 PARP1 ITCH TCP1 MICAL2 SIPA1L1 LIMCH1 IDH3B APP TRIP13 HCFC1 MRPS22 LARP7	1.93e-05	1247	90	13	27684187
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	VMP1 PARP1 DST TCP1 SIPA1L1 PUM3 LIMCH1 IDH3B ECPAS HPSE TRIP13 HCFC1 MRPS22 LARP7	1.94e-05	1440	90	14	30833792
Pubmed	Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2.	TCP1 HSF1	1.98e-05	3	90	2	10561509
Pubmed	Particulate matter increases beta-amyloid and activated glial cells in hippocampal tissues of transgenic Alzheimer's mouse: Involvement of PARP-1.	PARP1 APP	1.98e-05	3	90	2	29654761
Pubmed	Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1.	PARP1 HSF1	1.98e-05	3	90	2	14670820
Pubmed	Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets.	ITCH SPART	1.98e-05	3	90	2	20504295
Pubmed	Transforming growth factor-beta bound to soluble derivatives of the beta amyloid precursor protein of Alzheimer's disease.	TGFB2 APP	1.98e-05	3	90	2	2119582
Pubmed	Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.	APP RYR2	1.98e-05	3	90	2	28476886
Pubmed	The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis.	PARP1 HSF1	1.98e-05	3	90	2	29158484
Pubmed	TAG-1 is an inhibitor of TGFbeta2-induced neuronal death via amyloid beta precursor protein.	TGFB2 APP	1.98e-05	3	90	2	20184861
Pubmed	A direct interaction between transforming growth factor (TGF)-betas and amyloid-beta protein affects fibrillogenesis in a TGF-beta receptor-independent manner.	TGFB2 APP	1.98e-05	3	90	2	12867422
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	GRIP1 TTF2 DST SIPA1L1 MPDZ ECPAS TRIM37 DMTN	2.13e-05	446	90	8	24255178
Pubmed	UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.	ITCH HERC2 TRIP13	2.15e-05	21	90	3	37422473
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	IBTK ATP2C1 CEP290 SPART PUM3 LIMCH1 HERC2 ECPAS WDR59 LARP7	2.59e-05	754	90	10	33060197
Pubmed	Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism.	USP6 REXO4 ATP2C1 TCP1 RAB43 CEP290 LIMCH1 APP MRPS22 TBCE SLC4A2	2.73e-05	925	90	11	28986522
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	GPR50 TCP1 ODR4 CCNB2 TNFAIP8 APP ECPAS SLC4A2	2.95e-05	467	90	8	30194290
Pubmed	A critical role of VMP1 in lipoprotein secretion.	VMP1 APOB	3.96e-05	4	90	2	31526472
Pubmed	Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.	TET2 HCFC1	3.96e-05	4	90	2	23352454
Pubmed	TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS.	TET2 HCFC1	3.96e-05	4	90	2	23353889
Pubmed	Reduction of Tet2 exacerbates early stage Alzheimer's pathology and cognitive impairments in 2×Tg-AD mice.	TET2 APP	3.96e-05	4	90	2	31943063
Pubmed	Clustering of Genetic Anomalies of Cilia Outer Dynein Arm and Central Apparatus in Patients with Transposition of the Great Arteries.	DNAH9 DNAH11	3.96e-05	4	90	2	36140829
Pubmed	Endogenous spartin (SPG20) is recruited to endosomes and lipid droplets and interacts with the ubiquitin E3 ligases AIP4 and AIP5.	ITCH SPART	3.96e-05	4	90	2	19580544
Pubmed	Selective transport of neurotransmitters and modulators by distinct volume-regulated LRRC8 anion channels.	LRRC8A LRRC8B	3.96e-05	4	90	2	28193731
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	TTF2 PARP1 REXO4 AP2S1 ITCH DST TCP1 MICAL2 PUM3 HERC2 IDH3B TRIP13 WDR59	4.48e-05	1353	90	13	29467282
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	VMP1 AP2S1 ITCH ATP2C1 MICAL2 LRRC8A APOB SLC4A2	4.70e-05	499	90	8	22810586
Pubmed	Renal Deletion of LRRC8/VRAC Channels Induces Proximal Tubulopathy.	LRRC8A LRRC8B	6.59e-05	5	90	2	35777784
Pubmed	LRRC8 involved in B cell development belongs to a novel family of leucine-rich repeat proteins.	LRRC8A LRRC8B	6.59e-05	5	90	2	15094057
Pubmed	DNAH11 Localization in the Proximal Region of Respiratory Cilia Defines Distinct Outer Dynein Arm Complexes.	DNAH9 DNAH11	6.59e-05	5	90	2	26909801
Pubmed	Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets.	APOB PLIN2	6.59e-05	5	90	2	22238364
Pubmed	Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC.	LRRC8A LRRC8B	6.59e-05	5	90	2	24790029
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	FMNL3 TET2 IBTK DST KIF16B LRRC8A SPART ECPAS	7.07e-05	529	90	8	14621295
Pubmed	Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.	PARP1 TCP1 ECPAS TRIP13 HCFC1 LARP7 POLR3C	7.10e-05	390	90	7	17643375
Pubmed	The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis.	IBTK TCP1 SASS6 ECPAS TRIP13 MRPS22 ANAPC4	7.81e-05	396	90	7	26687479
Pubmed	Mild recessive mutations in six Fraser syndrome-related genes cause isolated congenital anomalies of the kidney and urinary tract.	GRIP1 FRAS1	9.87e-05	6	90	2	24700879
Pubmed	CFAP53 regulates mammalian cilia-type motility patterns through differential localization and recruitment of axonemal dynein components.	DNAH9 DNAH11	9.87e-05	6	90	2	33347437
Pubmed	Quantitative trait analysis of the development of pulmonary tolerance to inhaled zinc oxide in mice.	TGFB2 PARP1	9.87e-05	6	90	2	16026622
Pubmed	Craniofacial consequences of connective tissue disorders in mice.	GRIP1 FRAS1	9.87e-05	6	90	2	6391574
Pubmed	Frem3, a member of the 12 CSPG repeats-containing extracellular matrix protein family, is a basement membrane protein with tissue distribution patterns distinct from those of Fras1, Frem2, and QBRICK/Frem1.	GRIP1 FRAS1	9.87e-05	6	90	2	17462874
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH9 DNAH11	1.38e-04	7	90	2	31178125
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ANKRD36B TET2 KIF16B ANKRD36	1.41e-04	101	90	4	10997877
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	CCNB2 SIPA1L1 SASS6 TRIM37	1.41e-04	101	90	4	24613305
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	CEP290 HERC2 ECPAS DNAH9	1.58e-04	104	90	4	9205841
Pubmed	A role for ubiquitin ligases and Spartin/SPG20 in lipid droplet turnover.	ITCH SPART	1.84e-04	8	90	2	19307600
Pubmed	Divergent hTAFII31-binding motifs hidden in activation domains.	HSF1 HCFC1	1.84e-04	8	90	2	10821850
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	ADCY10 PARP1 TCP1 SIPA1L1 LRRK2	2.12e-04	208	90	5	33230847
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE2B SPDYE6	2.36e-04	9	90	2	36272447
Pubmed	Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.	PARP1 HERC2	2.36e-04	9	90	2	30987826
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	TCP1 CEP290 HAUS3 HERC2 IDH3B TRIM37 MRPS22 ANAPC4	2.57e-04	639	90	8	23443559
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	DST HERC2 APP TRIM37	2.74e-04	120	90	4	31413325
Pubmed	The TIP60 Complex Is a Conserved Coactivator of HIF1A.	IDH3B ECPAS TRIP13 HCFC1	2.74e-04	120	90	4	27320910
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	USP6 PARP1 ITCH SIPA1L1 SASS6 MPDZ HERC2 TRIP13 HCFC1 WDR59	2.75e-04	1005	90	10	19615732
Pubmed	Disorders of Intracellular Cobalamin Metabolism	HCFC1 MMADHC	2.94e-04	10	90	2	20301503
Pubmed	Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene.	MPDZ PLIN2	2.94e-04	10	90	2	11978849
Pubmed	The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway.	LRRK2 HERC2	2.94e-04	10	90	2	26355680
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	PARP1 AP2S1 DST TCP1 SACS MICAL2 SIPA1L1 LIMCH1 IDH3B MRPS22 DMTN DNAH11	3.17e-04	1431	90	12	37142655
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	PARP1 DST TCP1 SACS CEP290 PUM3 HERC2 IDH3B APP TRIP13	3.19e-04	1024	90	10	24711643
Pubmed	Synaptic vesicle trafficking and Parkinson's disease.	SNCAIP LRRK2	3.59e-04	11	90	2	21563316
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	GRIP1 TET2 ITCH DST SIPA1L1 MPDZ LIMCH1 WDR59 DMTN	3.95e-04	861	90	9	36931259
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	TGFB2 VMP1 AP2S1 ITCH ODR4 LRRC8A APOB TBCE SLC4A2 PLIN2	4.21e-04	1061	90	10	33845483
Pubmed	Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity.	LRRC8A LRRC8B	4.30e-04	12	90	2	32277911
Pubmed	Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling.	TRIP13 ANAPC4	4.30e-04	12	90	2	26986935
Pubmed	Using advanced intercross lines for high-resolution mapping of HDL cholesterol quantitative trait loci.	TGFB2 APP	4.30e-04	12	90	2	12805272
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	TTF2 LRRK2 DNAH9	4.43e-04	57	90	3	27433848
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	PARP1 FRAS1 ITCH SACS KIF16B SPART MPDZ HERC2 APP MRPS22 LARP7 SLC4A2	4.48e-04	1487	90	12	33957083
Pubmed	TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment.	PARP1 SPART APOB ECPAS	4.65e-04	138	90	4	37506885
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	VMP1 REXO4 AP2S1 DST SIPA1L1 MPDZ PUM3 LIMCH1 HERC2 APP MRPS22 LARP7	4.75e-04	1497	90	12	31527615
Pubmed	Yeast two-hybrid screens implicate DISC1 in brain development and function.	CEP290 DMTN	5.07e-04	13	90	2	14623284
Pubmed	The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability.	USP6 APP	5.07e-04	13	90	2	31841517
Pubmed	Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling.	PARP1 CEP290	5.07e-04	13	90	2	22863007
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE2B SPDYE6	5.07e-04	13	90	2	15611625
Pubmed	hnRNP U protein is required for normal pre-mRNA splicing and postnatal heart development and function.	PARP1 RYR2	5.07e-04	13	90	2	26039991
Pubmed	Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.	CCNB2 CEP290 SASS6 HAUS3	5.75e-04	146	90	4	21399614
Pubmed	Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.	RYR2 TBCE	5.91e-04	14	90	2	11472062
Pubmed	Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury.	FRAS1 COL6A5 APOB	6.23e-04	64	90	3	22261194
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	ITCH ATP2C1 SIPA1L1 LRRC8B IDH3B APP TRIP13 IQCM LARP7 ANAPC4	6.23e-04	1116	90	10	31753913
Interaction	PCM1 interactions	VMP1 TTF2 IBTK CCNB2 CEP290 SASS6 HAUS3 HERC2 IDH3B APP ECPAS CCDC65 TRIM37	6.54e-08	434	90	13	int:PCM1
Interaction	POU5F1 interactions	TTF2 IBTK PARP1 ITCH TCP1 LRRK2 SASS6 IDH3B ECPAS TRIP13 HCFC1 MRPS22 ANAPC4	1.89e-06	584	90	13	int:POU5F1
Interaction	SNCA interactions	GRIP1 PARP1 AP2S1 SNCAIP DST SACS LRRK2 PLCB2 IDH3B APP ECPAS HCFC1 MRPS22 DMTN	3.34e-06	716	90	14	int:SNCA
Interaction	KIF4A interactions	TTF2 PARP1 TBC1D23 APP HSF1 ANAPC4	8.90e-06	108	90	6	int:KIF4A
Interaction	SUB1 interactions	TET2 PARP1 ITCH LRRK2 APP HSF1 TRIM37 POLR3C	1.48e-05	247	90	8	int:SUB1
Interaction	DISC1 interactions	ITCH DST CEP290 LRRC8A HAUS3 HERC2 TRIM37 LARP7 DMTN POLR3C	2.16e-05	429	90	10	int:DISC1
Interaction	TUBB interactions	TET2 TTF2 PARP1 ARHGAP24 TCP1 CEP290 LRRK2 APP ECPAS HSF1 TRIM37 LARP7 TBCE	2.24e-05	735	90	13	int:TUBB
Interaction	UBE2S interactions	PARP1 ITCH HERC2 APP TRIP13 ANAPC4	3.59e-05	138	90	6	int:UBE2S
Interaction	CTNNB1 interactions	GRIP1 PARP1 ARHGAP24 DST AUH TCP1 SIPA1L1 LRRK2 MPDZ LIMCH1 HERC2 IDH3B APP HSF1 TRIM37	3.78e-05	1009	90	15	int:CTNNB1
Interaction	ATG16L1 interactions	PARP1 AP2S1 TCP1 SIPA1L1 KIF16B SASS6 CCDC168 TNFAIP8 TBC1D23 APP HCFC1 TRIM37 MRPS22 RYR2 DMTN PDZD4	5.03e-05	1161	90	16	int:ATG16L1
Interaction	CEP128 interactions	TTF2 IBTK AP2S1 CCNB2 SIPA1L1 CEP290 HAUS3 TRIM37	5.51e-05	297	90	8	int:CEP128
Interaction	ZNF365 interactions	PARP1 SASS6 APP	7.92e-05	19	90	3	int:ZNF365
Interaction	EPB42 interactions	LARP7 DMTN SLC4A2	7.92e-05	19	90	3	int:EPB42
Interaction	BUB3 interactions	PARP1 REXO4 TCP1 HERC2 HSF1 HCFC1 ANAPC4	8.13e-05	232	90	7	int:BUB3
Interaction	ACTB interactions	TET2 TTF2 PARP1 ARHGAP24 DST TCP1 SIPA1L1 LRRK2 LIMCH1 APP HSF1 TRIM37 LARP7 DMTN TBCE	8.43e-05	1083	90	15	int:ACTB
Interaction	BAG2 interactions	TTF2 AP2S1 LRRK2 KIF16B HAUS3 TBC1D23 HSF1 HPSE TRIM37 LARP7 TBCE	1.01e-04	622	90	11	int:BAG2
Interaction	RASL10B interactions	PARP1 TCP1 APP MMADHC	1.14e-04	56	90	4	int:RASL10B
Interaction	HDAC4 interactions	PARP1 AUH TCP1 SIPA1L1 LRRC8A MPDZ LRRC8B LIMCH1 HERC2 APP TRIP13 LARP7	1.15e-04	744	90	12	int:HDAC4
Interaction	KCNA3 interactions	GRIP1 ADCY10 TTF2 PARP1 DST TCP1 SIPA1L1 LRRK2 SPART MPDZ ECPAS HCFC1 TBCE	1.27e-04	871	90	13	int:KCNA3
Interaction	MKI67 interactions	FMNL3 PARP1 FRAS1 DST TCP1 SIPA1L1 PUM3 ECPAS HCFC1 TRIM37 MRPS22	1.45e-04	648	90	11	int:MKI67
Interaction	HSP90B1 interactions	ARHGAP24 AUH LRRK2 LRRC8A ANKRD30B APOB HERC2 APP HSF1 TRIM37 LARP7	1.49e-04	650	90	11	int:HSP90B1
Interaction	CEP63 interactions	DST SIPA1L1 SASS6 HAUS3 TRIM37 POLR3C	1.52e-04	179	90	6	int:CEP63
Interaction	LATS1 interactions	TET2 ITCH SIPA1L1 CEP290 LRRK2 MPDZ TNFAIP8 IDH3B APP	1.54e-04	440	90	9	int:LATS1
GeneFamily	Volume regulated anion channel subunits	LRRC8A LRRC8B	1.15e-04	5	62	2	1158
GeneFamily	PDZ domain containing	GRIP1 SIPA1L1 MPDZ PDZD7 PDZD4	1.73e-04	152	62	5	1220
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE2B SPDYE6	7.47e-04	12	62	2	756
GeneFamily	Ankyrin repeat domain containing	ANKRD36B IBTK SNCAIP ANKRD30B ANKRD36	1.43e-03	242	62	5	403
GeneFamily	Dyneins, axonemal	DNAH9 DNAH11	1.52e-03	17	62	2	536
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TGFB2 USP6 IBTK ITCH ATP2C1 DST AUH SACS MICAL2 SIPA1L1 SPART PUM3 TNFAIP8 APP TRIM37	2.12e-07	856	90	15	M4500
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ANKRD36B MPDZ ANKRD36 DNAH9 SPDYE6 DNAH11	7.72e-07	156	90	6	10d191e29b16cae8238e8df6c0ff38882253f34e
ToppCell	(03)_KRT6B+-(2)_GFP_FOXI1\|(03)_KRT6B+ / shred by cell type by condition	TET2 DST CEP290 ANKRD36 LIMCH1 LARP7	3.17e-06	199	90	6	c425e7975f492ed5cfcca022248adb627e1d27d4
ToppCell	Parenchyma_Control_(B.)-Stromal-TX-Fibroblasts-1\|Parenchyma_Control_(B.) / Sample group, Lineage and Cell type	IGSF10 FRAS1 DST COL6A5 LIMCH1 RYR2	3.27e-06	200	90	6	aa1a35dcca3b799241eef4237f6eb94660e019f0
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	IGSF10 FRAS1 DST COL6A5 LIMCH1 RYR2	3.27e-06	200	90	6	a510deaada669e690329183e18df02870bd204b3
ToppCell	Lung_Parenchyma-Control-Mesenchymal-Mesenchymal-Fibroblasts-1-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	IGSF10 FRAS1 DST COL6A5 LIMCH1 RYR2	3.27e-06	200	90	6	dd4228cbed8a4395166a6332e08d44d88bebe3b9
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIP1 FRAS1 COL6A5 DNAH9 RYR2	1.84e-05	160	90	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 DST COL6A5 LIMCH1 RYR2	1.84e-05	160	90	5	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP24 DST COL6A5 LIMCH1 RYR2	1.84e-05	160	90	5	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIP1 FRAS1 COL6A5 DNAH9 RYR2	1.84e-05	160	90	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 SLC34A1 CCNB2 GATM RYR2	1.90e-05	161	90	5	b9a17f41426bf715f30bf544a6795afaf37a3aa6
ToppCell	facs-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC9C1 SLC34A1 CCNB2 GATM RYR2	1.90e-05	161	90	5	f7a89c481f789f624102857be722c95fbeb47595
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Differentiating_glia\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB2 FRAS1 DST FAM78B APP	2.60e-05	172	90	5	bc3ed05fdd94d5e1f19285aea867b1453292baec
ToppCell	droplet-Lung-nan-3m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC34A1 CEP290 PLCB2 HPSE PDZD4	2.68e-05	173	90	5	1b9b4e165121b08ef15a93fca6bea875cae69f19
ToppCell	droplet-Lung-nan-3m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC34A1 CEP290 PLCB2 HPSE PDZD4	2.68e-05	173	90	5	c25f24d7b672c9686d31ebc8d263042282f520fd
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAB43 GATM TRIP13 PDZD4 DNAH11	2.68e-05	173	90	5	15af4a0f7516dbf5c93ba66a19aca073ebe30d04
ToppCell	LPS-IL1RA+antiTNF\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	IGSF10 AUH LRRK2 COL6A5 LIMCH1	2.99e-05	177	90	5	b7fee75de7e96924af488a5baa2334711889ae7c
ToppCell	356C-Fibroblasts-Fibroblast-G\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 DST COL6A5 LIMCH1 RYR2	2.99e-05	177	90	5	8220cc2fc0ee8764a67a3be51d75248be2453040
ToppCell	356C-Fibroblasts-Fibroblast-G-\|356C / Donor, Lineage, Cell class and subclass (all cells)	FRAS1 DST COL6A5 LIMCH1 RYR2	2.99e-05	177	90	5	7617270f49cd6b7ba66db72d20560cee985012b2
ToppCell	Ciliated_cells-A-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	FNDC11 CCDC65 DNAH9 PDZD4 DNAH11	3.07e-05	178	90	5	255473ee6df8a13079fb3bb61038162a40cb4c2c
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TGFB2 ARHGAP24 AFAP1L2 FNDC11 APP	3.15e-05	179	90	5	55bc69f107fc710db7617c428575792adfdbbcc1
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 FRAS1 AFAP1L2 CCDC42 LIMCH1	3.41e-05	182	90	5	f96095b81188b52db8fcfca4837129cfcd9bd7b7
ToppCell	facs-Lung-nan-3m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AFAP1L2 SNCAIP DST LPAR4 MICAL2	3.50e-05	183	90	5	12e876d6205af8aad74265c668b5e95b9e7487f3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TGFB2 ARHGAP24 AFAP1L2 FNDC11 APP	3.50e-05	183	90	5	83592c332b1e82673f993d37c7f480befdc3dcda
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	TGFB2 GRIP1 SLC9C1 MICAL2 LIMCH1	3.50e-05	183	90	5	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 APOB DNAH9 RYR2 DNAH11	3.59e-05	184	90	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	COPD-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	3.59e-05	184	90	5	ceec41ed5636032aaf7716d1203816ea58bd39bd
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 APOB DNAH9 RYR2 DNAH11	3.59e-05	184	90	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 APOB DNAH9 RYR2 DNAH11	3.59e-05	184	90	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGSF10 DST LPAR4 COL6A5 RYR2	3.78e-05	186	90	5	5473283fb95cee556b1f6934cf72169b676b5bcc
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l27\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AFAP1L2 SNCAIP LPAR4 MICAL2 CCDC65	3.78e-05	186	90	5	c116cc9f41971622264434ebe29d18e719b0ae19
ToppCell	COPD-Myeloid-cMonocyte\|COPD / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.08e-05	189	90	5	d29f3a0bd23e6eb46389e6eb7ef21851c7b57545
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.08e-05	189	90	5	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	IPF-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.08e-05	189	90	5	ad7bb3a7de8e48c145e4382f90d30bb2159c2b76
ToppCell	hematopoetic_progenitors-CD34+_HSC\|World / Lineage and Cell class	IGSF10 ATP2C1 CCDC42 MPDZ LIMCH1	4.08e-05	189	90	5	51ff31c9cf5eff98ad01c0455dc4ae4908713575
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GRIP1 DST GATM LIMCH1 PID1	4.19e-05	190	90	5	4b25d49f033bbd326b47cf5602af3f0262cfc367
ToppCell	IPF-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.19e-05	190	90	5	ffa890138394f579fee53fcfac6c121bf86adc26
ToppCell	IPF-Myeloid-cMonocyte\|IPF / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.19e-05	190	90	5	a099f51f2b7618b6712af38eedd5ee64d8663a4a
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FRAS1 DST COL6A5 LIMCH1 RYR2	4.29e-05	191	90	5	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	FRAS1 DST COL6A5 LIMCH1 RYR2	4.29e-05	191	90	5	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	systemic_lupus_erythematosus-flare-Myeloid-conventional_dendritic_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	GRIP1 DST GATM LIMCH1 PID1	4.40e-05	192	90	5	8e606eae3e5b07a856d3c2a74186d486da96309c
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	FRAS1 ARHGAP24 DST LIMCH1 RYR2	4.40e-05	192	90	5	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.74e-05	195	90	5	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGSF10 DST COL6A5 LIMCH1 RYR2	4.74e-05	195	90	5	df409f94f4e83be89f7a608058ee07ce3ce3a149
ToppCell	5'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGSF10 DST COL6A5 LIMCH1 RYR2	4.74e-05	195	90	5	4243190ad291d56694e2155954dbaa879c9d3844
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	TET2 VMP1 SIPA1L1 LRRK2 PID1	4.74e-05	195	90	5	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_hypoxia-Z\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TET2 AP2S1 HPSE PID1 PLIN2	4.85e-05	196	90	5	7dff78ff7b2b333680de1c9ca78190770574d796
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGSF10 DST COL6A5 LIMCH1 RYR2	4.85e-05	196	90	5	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	Caecum-T_cell-Tfh\|T_cell / Region, Cell class and subclass	ADCY10 KIF16B TBC1D23 APP DNAH9	4.85e-05	196	90	5	fe2ee5788028e6b671674f0cc50e2b6379f50976
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGSF10 DST COL6A5 LIMCH1 RYR2	4.85e-05	196	90	5	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	LPS_anti-TNF-Mesenchymal_fibroblastic-Fibroblasts-Activated_MatrixFB\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	IGSF10 DST COL6A5 LIMCH1 RYR2	4.97e-05	197	90	5	fdb92985f7df0c280b87d3e43c2394e70786a2c7
ToppCell	368C-Fibroblasts-Fibroblast-G\|368C / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 FRAS1 DST COL6A5 LIMCH1	4.97e-05	197	90	5	156155c2f0c1a2461e45803da578af18ee221660
ToppCell	368C-Fibroblasts-Fibroblast-G-\|368C / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 FRAS1 DST COL6A5 LIMCH1	4.97e-05	197	90	5	d5d9263451f6c10cb3b9c17740183ca334e24851
ToppCell	Healthy/Control-cDC\|World / Disease group and Cell class	GRIP1 DST GATM LIMCH1 PID1	4.97e-05	197	90	5	4497d4073f4d3e74de907325fba9eb4af5766bf4
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	IGSF10 DST COL6A5 LIMCH1 RYR2	4.97e-05	197	90	5	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-G\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	IGSF10 FRAS1 DST COL6A5 LIMCH1	4.97e-05	197	90	5	a21a710c824f9e5c7ef1674168d1ce5aef85bd35
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial-Astrocyte\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	TGFB2 LPAR4 SIPA1L1 GATM SPART	5.09e-05	198	90	5	bfad1c51cf884ff7ce89f8278820800582541dc7
ToppCell	severe-HLA-DR+_CD83+_Monocyte\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TET2 VMP1 MICAL2 LRRK2 PID1	5.09e-05	198	90	5	a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Macroglial\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	TGFB2 LPAR4 SIPA1L1 GATM SPART	5.09e-05	198	90	5	6372e65242236c497d9b3be147092897c1609d22
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGSF10 DST COL6A5 LIMCH1 RYR2	5.09e-05	198	90	5	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	Control_saline\|World / Treatment groups by lineage, cell group, cell type	TGFB2 FRAS1 DST MPDZ APP	5.22e-05	199	90	5	11c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell	LPS_IL1RA-Mesenchymal_fibroblastic-Fibroblasts-MatrixFB\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	IGSF10 DST COL6A5 LIMCH1 RYR2	5.22e-05	199	90	5	a7dd94b172c973a131a6792f8ccd9bfe44d984ac
ToppCell	(5)_Fibroblast-G\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	IGSF10 FRAS1 DST COL6A5 LIMCH1	5.22e-05	199	90	5	b4a737575be9f8c65771832dd8cd25328d5dae0d
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB2 FRAS1 AFAP1L2 DST APP	5.22e-05	199	90	5	a76aa30fb264bdcbc0cb09113f814fc5a89e7319
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	IGSF10 DST COL6A5 LIMCH1 RYR2	5.22e-05	199	90	5	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	343B-Fibroblasts-Fibroblast-G\|343B / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 DST COL6A5 LIMCH1 RYR2	5.22e-05	199	90	5	f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell	343B-Fibroblasts-Fibroblast-G-\|343B / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 DST COL6A5 LIMCH1 RYR2	5.22e-05	199	90	5	9c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TGFB2 FRAS1 DST FAM78B APP	5.22e-05	199	90	5	1761669ec514fdb4175042f11b9a31fa5687fc2b
ToppCell	343B-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 FRAS1 DST COL6A5 LIMCH1	5.22e-05	199	90	5	212e89d097753790061310373a1fafba773488b6
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AFAP1L2 SNCAIP LIMCH1 TNFAIP8 PID1	5.22e-05	199	90	5	4217b9e66c5374461e84bdb893ab650f148286c8
ToppCell	343B-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	IGSF10 FRAS1 DST COL6A5 LIMCH1	5.22e-05	199	90	5	14b676aa289c0578a37be32cec3ea285c79d97cc
ToppCell	Parenchymal-10x5prime-Stromal-Fibroblastic-Fibro_alveolar\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	IGSF10 FRAS1 COL6A5 LIMCH1 RYR2	5.34e-05	200	90	5	8c62f05c6042f24287a73fbdf80ff4a56f7ff403
ToppCell	MS-IIF-Myeloid-cDC\|IIF / Disease, condition lineage and cell class	GRIP1 AP2S1 DST LIMCH1 PID1	5.34e-05	200	90	5	620a82805619d113182d59740670c9f9b93ee924
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 SLC9C1 FNDC11 APOB	6.36e-05	106	90	4	8cae594c91b61dc5b12d27e44e68de71956dfff7
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GATM PUM3 LIMCH1 ECPAS	9.65e-05	118	90	4	f0f40a0165156e3fc1584480b473b0e84e10d2cc
ToppCell	PBMC-Mild-Myeloid-cDC-cDC-cDC_12\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GATM PUM3 LIMCH1 ECPAS	9.97e-05	119	90	4	a6b359e7aafcc197f53eb5e19c3a905bc09497bb
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 SLC9C1 ACSBG2 TDRD1	1.86e-04	140	90	4	7ca49bd7ba9381e75c10f888775df17e5d46804d
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADCY10 SLC9C1 ACSBG2 TDRD1	1.86e-04	140	90	4	1a31bc33d5723b9bc528cc0047ca5f4c80531c7a
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 CCNB2 N6AMT1 LIMCH1	2.25e-04	147	90	4	b66ccc710b3c04f6fc7fed69f3c892fc110e98fc
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_PRSS12\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAB43 CCDC168 TDRD1 PID1	2.55e-04	152	90	4	653e3dc80c54c16730c5ba0187fc1f663761fc87
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 SLC34A1 COL6A5 APOB	2.89e-04	157	90	4	8d30d8e6fae93afcada6bd68799439335cd65b69
ToppCell	facs-Heart-Unknown-3m-Myeloid\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 SLC34A1 COL6A5 APOB	2.89e-04	157	90	4	2ac4695d9e4ca8d4ba19c555e9a1d86ac8f398ab
ToppCell	facs-Heart-Unknown-3m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 SLC34A1 COL6A5 APOB	2.89e-04	157	90	4	8a393eece90fb9a1b7c356736bdb36277261fbd3
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	RAB43 CCDC168 TDRD1 PID1	2.96e-04	158	90	4	551e3fd7cabc94ba933607ccdcf93f4e799be43a
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL6A5 CCDC65 DNAH9 DNAH11	3.03e-04	159	90	4	00a157d033627d0e65c3fbd38d652c4cf56b47f6
ToppCell	Adult-Mesenchymal-airway_smooth_muscle_cell-D122\|Adult / Lineage, Cell type, age group and donor	SACS ACSBG2 HCFC1 RYR2	3.18e-04	161	90	4	64891f6f2ee1693c8481e951b9346e2f92d602e3
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRIP1 FRAS1 AFAP1L2 LIMCH1	3.25e-04	162	90	4	285e6d553f485fd9f1075c4e1b940da251b5ea35
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell-plasmacytoid_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC34A1 PLCB2 HPSE PDZD4	3.41e-04	164	90	4	cfe07a1ebed8aecb08d0476db71fe314998d54aa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-plasmacytoid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC34A1 PLCB2 HPSE PDZD4	3.41e-04	164	90	4	6d331e74efecb4733d87653f86cd67247be05025
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SLC34A1 GATM DNAH9 IQCM	3.65e-04	167	90	4	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	wk_15-18-Hematologic-Meg-ery-Megakaryocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ATP2C1 LRRC8B HPSE DMTN	3.82e-04	169	90	4	d571e84e01e3316748d4407ed98881b17484e035
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 DNAH9 RYR2 DNAH11	3.82e-04	169	90	4	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	systemic_lupus_erythematosus-flare-Lymphocytic_T-T4_reg-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	FAM78B HAUS3 ANKRD36 TNFAIP8	4.08e-04	172	90	4	9497948bbe53fb88c6ff6b347f743d456da587e5
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAB43 LRRK2 GATM PLCB2	4.08e-04	172	90	4	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC2-cDC2_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGAP24 GATM SASS6 TNFAIP8	4.08e-04	172	90	4	eba1568d4307e91c94fc616549057cbed8df5840
ToppCell	droplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	RAB43 LRRK2 GATM PLCB2	4.17e-04	173	90	4	70c0c13febd28b395fb3171ec8d7fbbc6c9d4eb7
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TGFB2 FRAS1 SLC9C1 LIMCH1	4.17e-04	173	90	4	b799c06a6a5754668e789f70c0c8bc1508568575
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_1\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	MICAL2 N6AMT1 HPSE TBCE	4.26e-04	174	90	4	58300d64d3b6fd9ba1b6c87ea83b2777eb6be2f4
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APP HPSE PID1 PLIN2	4.35e-04	175	90	4	69b59ec58e64644deb7e07f31ef495ef4a6f6276
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	FMNL3 IGSF10 USP6 APP	4.35e-04	175	90	4	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	facs-Marrow-B-cells-24m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRAS1 ANKRD36 DNAH9 RYR2	4.35e-04	175	90	4	887e75fc90e59a6394d62f3c048a9cfdf6707725
Disease	Cryptophthalmos syndrome	GRIP1 FRAS1	2.63e-05	3	88	2	C0265233
Disease	FRASER SYNDROME 1	GRIP1 FRAS1	2.63e-05	3	88	2	C4551480
Disease	Fraser syndrome (implicated_via_orthology)	GRIP1 FRAS1	5.26e-05	4	88	2	DOID:0090001 (implicated_via_orthology)
Disease	response to platinum based chemotherapy, cytotoxicity measurement	FRAS1 SNCAIP	8.74e-05	5	88	2	EFO_0004647, EFO_0006952
Disease	clubfoot (implicated_via_orthology)	GRIP1 FRAS1	1.31e-04	6	88	2	DOID:11836 (implicated_via_orthology)
Disease	Malignant mesothelioma	TGFB2 PARP1 LIMCH1 RYR2	3.24e-04	109	88	4	C0345967
Disease	Primary Ciliary Dyskinesia	CCDC65 DNAH9 DNAH11	3.78e-04	47	88	3	C4551720
Disease	Disorders of Intracellular Cobalamin Metabolism	HCFC1 MMADHC	3.90e-04	10	88	2	cv:CN043592
Disease	Disorder of eye	GRIP1 FRAS1 CEP290 PDZD7 IDH3B	4.41e-04	212	88	5	C0015397
Disease	response to bronchodilator, FEV/FEC ratio	TGFB2 GRIP1 TET2 PARP1 SIPA1L1 RAB43 KIF16B WDR59 TRIM37	4.69e-04	766	88	9	EFO_0004713, GO_0097366
Disease	chronic kidney disease	PARP1 SLC34A1 GATM COL6A5 PLCB2	7.03e-04	235	88	5	EFO_0003884
Disease	attention function measurement	GRIP1 SNCAIP DST PLIN2	1.02e-03	148	88	4	EFO_0007636
Disease	diabetic neuropathy (biomarker_via_orthology)	TGFB2 LRRK2	1.16e-03	17	88	2	DOID:9743 (biomarker_via_orthology)
Disease	Parkinson disease	SNCAIP LRRK2	1.95e-03	22	88	2	cv:C0030567
Disease	Coronary heart disease	APOB DNAH11	2.33e-03	24	88	2	C0010068
Disease	Dyslipidemias	APOB DNAH11	2.33e-03	24	88	2	C0242339
Disease	Dyslipoproteinemias	APOB DNAH11	2.33e-03	24	88	2	C0598784
Disease	Bone Diseases, Developmental	TGFB2 SLC34A1	2.94e-03	27	88	2	C0005941

Protein segments in the cluster

Peptide	Gene	Start	Entry
RSLQLKKTMEIKGTV	TDRD1	256	Q9BXT4
TLVKKKIPIISNAML	ACSBG2	531	Q5FVE4
TLIISKKERMLQKGS	SLC4A2	1016	P04920
LMNQLTVKGLKKLGQ	ANAPC4	321	Q9UJX5
LQMTLKLKQKTVTKR	ANKRD30B	1126	Q9BXX2
IVITLVMLKKKQYTS	APP	716	P05067
QKLQDAITISKGKIM	CCDC65	266	Q8IXS2
MNTTTKEKIILQTIK	FAM78B	176	Q5VT40
LKLSNLMNLGRKKST	AFAP1L2	331	Q8N4X5
QAPVVLKMVKILTTK	DNAH11	296	Q96DT5
KKKVSLLNIATRIMG	ANKRD36	626	A6QL64
KKKVSLLNIATRIMG	ANKRD36B	336	Q8N2N9
SRMSTLKKQKQLEIL	ADCY10	611	Q96PN6
KKTLLLGTIKMATLN	CCDC42	251	Q96M95
MKIIKSLQKNGSVVA	ATP2C1	626	P98194
TSQTKVLKQLLMLQS	AP2S1	126	P53680
IQMEKSKTTITNLKI	KIF16B	26	Q96L93
TMKTLEIQGKRVKLQ	RAB43	56	Q86YS6
ITKGQVKLDKIMTII	IQCM	126	A0A1B0GVH7
VKLMSDLQKLIQGKI	PUM3	156	Q15397
SNMKILTLGKLSRNK	PARP1	391	P09874
NEGTKLIVLNSLKKM	LRRC8A	576	Q8IWT6
LISNLGKVMSVVQTK	HCFC1	676	P51610
GKLMILTVTQKTKND	MMADHC	171	Q9H3L0
GKATNLITKKELLTM	FRAS1	2456	Q86XX4
KMFEKLGITTIKVNI	GATM	381	P50440
NSLSKNLIKMLSKAV	AUH	101	Q13825
NTTQLKPKMVKVLLG	HERC2	3136	O95714
VKLSQKQRKMIALTT	IBTK	1151	Q9P2D0
KSTIANLMGKAKTII	DST	861	Q03001
TLSQIGTNKKKVLKM	LPAR4	236	Q99677
NSMVILAVTKNKKLR	GPR50	46	Q13585
NTLVKISKSAGAMLK	ECPAS	1276	Q5VYK3
SVTKLLTDVQLMKGK	HSF1	136	Q00613
QTMLKSKLNVLTLKK	PID1	46	Q7Z2X4
KTTMLLKIQQNIGVI	ODR4	421	Q5SWX8
KVMLQVNGKELSKLS	PDZD4	16	Q76G19
KTVTLSKMKQSLGIS	PDZD7	861	Q9H5P4
GKTTLLQQLMKTKKS	LRRK2	1346	Q5S007
ISLLVSFNKMKKLTT	LARP7	71	Q4G0J3
KKLVGTKVLMASVQG	HPSE	411	Q9Y251
EGSKLVVLNNLKKMV	LRRC8B	571	Q6P9F7
GKLVTKMFQKIQDLI	TRIP13	226	Q15645
KMLNSLLKGQVAKVI	SLC34A1	371	Q06495
MKSQLQITVISAKLK	ITCH	16	Q96J02
SLVSSLKQEMTKQKI	ARHGAP24	646	Q8N264
LKCVQSTKPSLMIQK	APOB	511	P04114
LSSMKENKVAIIGKI	IDH3B	101	O43837
VNVKMLSSTTNKLLL	IGSF10	931	Q6WRI0
SKLLKISMIPQLNSK	CCNB2	371	O95067
EKLTLQRKLKTTGMT	CEP290	1956	O15078
MKKVGTAQTKIQLLL	FNDC11	111	Q9BVV2
SVKSSQKLKQMLEII	FMNL3	756	Q8IVF7
MKNLLTKIQIGADKT	COL6A5	651	A8TX70
KKLKQSQGILNAMIT	HAUS3	146	Q68CZ6
KKQVAQLKTLITMLI	DNAH9	1751	Q9NYC9
QLKTLITMLIGQLSK	DNAH9	1756	Q9NYC9
LKKMKSSISQGIQLD	CCDC168	4051	Q8NDH2
QMAGETVTLKIKKQT	GRIP1	741	Q9Y3R0
LSKVTSNLGKMILKE	DMTN	241	Q08495
TLMGKLKLKNTVTIQ	SASS6	396	Q6UVJ0
LLQSSEGKMTLKKIK	SACS	1141	Q9NZJ4
ILKSKTIQMLTEAVK	RYR2	1786	Q92736
VITSLKMLNAVKNKS	FPGT	551	O14772
MSGKVELVLSQKVVK	LIMCH1	701	Q9UPQ0
MTAKKQSLLDKGVII	MICAL2	301	O94851
ISQMGSKKKPKIIQQ	REXO4	91	Q9GZR2
QSILTKMTGLNLQKT	MRPS22	76	P82650
QLKNKLITLMGQKTS	TRIM37	196	O94972
ITSSKQIKQMLLKQV	SLC9C1	766	Q4G0N8
MLKSIQNTLKNKTRP	SIPA1L1	131	O43166
MSLASQVVKLTKQLK	SNCAIP	516	Q9Y6H5
LQKTKMKLGVQVVIT	TCP1	241	P17987
QKKILGKMVSKSIAT	TNFAIP8	26	O95379
GLKMKLKQQRVSSIL	SPDYE2B	101	A6NHP3
GLTKIQVKMEKLSST	CINP	101	Q9BW66
KTPKIEQLSNMIVKS	TGFB2	396	P61812
NIGIKAMVKKTATQT	SPART	606	Q8N0X7
LLNGKLTMSAVVKKV	POLR3C	111	Q9BUI4
ISLLKTAKMTVKLTI	MPDZ	1546	O75970
LEKQLPGSMTIQKVK	TBCE	461	Q15813
GLKMKLKQQRVSSIL	SPDYE6	101	P0CI01
LVNKMTVALKTKSVN	TBC1D23	486	Q9NUY8
ILVKLKMQLNSEGKI	PLCB2	151	Q00722
TTITSTMKAKLLKIL	WDR59	451	Q6PJI9
LTSSKGQLQKMKESL	PLIN2	371	Q99541
LTLKSQKQVKVEMSG	TET2	1046	Q6N021
SIALKVQQKRLMKTS	USP6	301	P35125
GKTLTMIALILTQKN	TTF2	601	Q9UNY4
ATLIGKAIIKMHIQK	VMP1	291	Q96GC9
EILKIMKTKGLQGTT	N6AMT1	181	Q9Y5N5