Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ ZNF358 ZNF644 SPDEF ONECUT3 ZNF345 NPAS1 ZNF311 ZNF573 ZNF607 IRF8 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ST18 ZNF646	1.90e-08	1412	200	38	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ SARS1 ZNF358 ZNF644 ONECUT3 ZNF345 NPAS1 ZNF311 ZNF573 ZNF607 IRF8 E4F1 ZNF101 ZNF251 ZNF768 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ST18 ZNF646	1.38e-07	1459	200	37	GO:0000977
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF444 ZNF140 ZNF154 ZNF225 ZNF829 ZNF836 WIZ SARS1 ZNF358 ZNF644 ONECUT3 ZNF345 ZNF311 ZNF573 ZNF607 IRF8 E4F1 ZNF101 ZNF251 ZNF768 ZNF540 ZSCAN5C ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ST18 ZNF646	1.86e-05	1244	200	29	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF444 ZNF140 ZNF154 ZNF225 ZNF829 ZNF836 WIZ SARS1 ZNF358 ZNF644 ONECUT3 ZNF345 ZNF311 ZNF573 ZNF607 IRF8 E4F1 ZNF101 ZNF251 ZNF768 ZNF540 ZSCAN5C ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ST18 ZNF646	2.77e-05	1271	200	29	GO:0000987
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	9.98e-05	2	200	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	9.98e-05	2	200	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	9.98e-05	2	200	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	9.98e-05	2	200	2	GO:0004354
Domain	Znf_C2H2/integrase_DNA-bd	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	3.98e-13	694	198	33	IPR013087
Domain	-	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	1.20e-12	679	198	32	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	1.61e-12	775	198	34	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	1.73e-12	777	198	34	PS00028
Domain	zf-C2H2	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 ZNF358 ZNF644 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	2.06e-12	693	198	32	PF00096
Domain	Znf_C2H2-like	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	3.39e-12	796	198	34	IPR015880
Domain	Znf_C2H2	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	4.63e-12	805	198	34	IPR007087
Domain	ZnF_C2H2	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 PRDM2 ZNF836 WIZ ZNF358 ZNF644 AEBP2 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	5.12e-12	808	198	34	SM00355
Domain	zf-C2H2_6	ZNF133 ZNF140 ZNF672 ZNF154 ZNF225 PRDM2 ZNF836 ZNF358 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF251 ZNF540 ZNF749 ZFP92 ZNF324B ZNF333 ZNF700 ZNF646	2.12e-11	314	198	21	PF13912
Domain	KRAB	ZNF133 ZNF140 ZNF154 ZNF225 ZNF829 ZNF836 ZNF311 ZNF573 ZNF607 ZNF101 ZNF251 ZNF517 ZNF540 ZNF749 ZFP92 ZNF565 ZNF324B ZNF333 ZNF700	9.38e-09	358	198	19	PS50805
Domain	KRAB	ZNF133 ZNF140 ZNF154 ZNF225 ZNF829 ZNF836 ZNF311 ZNF573 ZNF607 ZNF101 ZNF251 ZNF517 ZNF540 ZNF749 ZFP92 ZNF565 ZNF324B ZNF333 ZNF700	9.38e-09	358	198	19	PF01352
Domain	KRAB	ZNF133 ZNF140 ZNF154 ZNF225 ZNF829 ZNF836 ZNF311 ZNF573 ZNF607 ZNF101 ZNF251 ZNF517 ZNF540 ZNF749 ZFP92 ZNF565 ZNF324B ZNF333 ZNF700	1.53e-08	369	198	19	SM00349
Domain	KRAB	ZNF133 ZNF140 ZNF154 ZNF225 ZNF829 ZNF836 ZNF311 ZNF573 ZNF607 ZNF101 ZNF251 ZNF517 ZNF540 ZNF749 ZFP92 ZNF565 ZNF324B ZNF333 ZNF700	1.60e-08	370	198	19	IPR001909
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	1.12e-04	2	198	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	1.12e-04	2	198	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	1.12e-04	2	198	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	1.12e-04	2	198	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	1.12e-04	2	198	2	PF00208
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	1.12e-04	2	198	2	IPR033922
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	1.12e-04	2	198	2	PS00074
Domain	A1A_glycop	ORM1 ORM2	1.12e-04	2	198	2	IPR001500
Domain	ELFV_dehydrog	GLUD1 GLUD2	1.12e-04	2	198	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	1.12e-04	2	198	2	IPR033524
Domain	GFP-like	EGFL6 HMCN1 SUSD1	1.82e-04	11	198	3	IPR023413
Domain	-	EGFL6 HMCN1 SUSD1	1.82e-04	11	198	3	2.40.155.10
Domain	-	CHAF1B WDR46 CDC20B FBXW2 PLXND1 DDB1 MET SEMA4F LLGL2 CFAP52 WDR73 MAPKBP1	2.37e-04	333	198	12	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	CHAF1B WDR46 CDC20B FBXW2 PLXND1 DDB1 MET SEMA4F LLGL2 CFAP52 WDR73 MAPKBP1	2.50e-04	335	198	12	IPR015943
Domain	EGF_CA	NPNT EGFL6 HMCN1 MEGF8 SUSD1 LRP2	3.06e-04	86	198	6	PF07645
Domain	Plexin_repeat	PLXND1 MET SEMA4F MEGF8	3.49e-04	32	198	4	IPR002165
Domain	PSI	PLXND1 MET SEMA4F MEGF8	3.49e-04	32	198	4	PF01437
Domain	EGF_Ca-bd_CS	NPNT EGFL6 HMCN1 MEGF8 SUSD1 LRP2	5.84e-04	97	198	6	IPR018097
Domain	MAM_1	PTPRM NPNT EGFL6	5.94e-04	16	198	3	PS00740
Domain	EGF_CA	NPNT EGFL6 HMCN1 MEGF8 SUSD1 LRP2	6.51e-04	99	198	6	PS01187
Domain	ASX_HYDROXYL	NPNT EGFL6 HMCN1 MEGF8 SUSD1 LRP2	6.87e-04	100	198	6	PS00010
Domain	MAM	PTPRM NPNT EGFL6	7.15e-04	17	198	3	SM00137
Domain	MAM	PTPRM NPNT EGFL6	8.51e-04	18	198	3	PF00629
Domain	MAM_dom	PTPRM NPNT EGFL6	8.51e-04	18	198	3	IPR000998
Domain	MAM_2	PTPRM NPNT EGFL6	8.51e-04	18	198	3	PS50060
Domain	EGF-type_Asp/Asn_hydroxyl_site	NPNT EGFL6 HMCN1 MEGF8 SUSD1 LRP2	9.32e-04	106	198	6	IPR000152
Domain	PSI	PLXND1 MET SEMA4F MEGF8	1.19e-03	44	198	4	IPR016201
Domain	Growth_fac_rcpt_	NPNT EGFL6 HMCN1 MEGF8 SUSD1 LRP2 PCSK4	1.39e-03	156	198	7	IPR009030
Domain	PSI	PLXND1 MET SEMA4F MEGF8	1.41e-03	46	198	4	SM00423
Pubmed	BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A.	GDPD1 CHAF1B RDH13 WIZ FAM83D CRYZL1 TLK2 NUDT16 ZNF768 CASK RAB3GAP1 SLC34A1 WDR73	1.28e-06	419	203	13	33001583
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MAN2A2 MFHAS1 PLXND1 ADCY7 CDR2L KMT2C BMP4 TLK1 WIZ AP3D1 SEMA4F AOC2 ZDHHC5 SRGAP2 MED13L LLGL2 MEGF8 ARHGEF4 ZNF324B MAPKBP1 ULK2	2.33e-06	1105	203	21	35748872
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ABCF1 MFHAS1 DDB1 EFTUD2 ZNF836 SARS1 TLK2 ZNF311 COPG1 ZNF251 CSE1L ZNF540 ZNF749	2.87e-06	451	203	13	36168627
Pubmed	Human Tousled like kinases are targeted by an ATM- and Chk1-dependent DNA damage checkpoint.	CHEK1 TLK1 TLK2	3.87e-06	6	203	3	12660173
Pubmed	BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.	ABCF1 GIPC2 ACAT1 PFKL INTS3 DDB1 KMT2C SARS1 TXNDC5 HEPHL1 COPG1 TRMT112 UBE2O CSE1L ARFGAP1 RBM34	4.97e-06	711	203	16	33022573
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	CHAF1B SMC1A DLGAP5 DDB1 PRDM2 WIZ ZNF644 CENPT RADX DDX55 UBE2O SLC4A1AP RBM34 KDM4B	1.53e-05	608	203	14	36089195
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF133 ZNF444 PDE3B TTLL3 ADGRG1 ADGRV1 PFKL INTS3 FARP2 PLEKHH1 KMT2C TLK1 EXD3 PTPRG MMP16 BEST1 SRGAP2 ATP10A CASK ZBTB46 ARHGEF4 CSMD1 KDM4B	2.22e-05	1489	203	23	28611215
Pubmed	Distal promoter regions are responsible for differential regulation of human orosomucoid-1 and -2 gene expression and acute phase responses.	ORM1 ORM2	3.39e-05	2	203	2	24389491
Pubmed	A new strategy for identification of N-glycosylated proteins and unambiguous assignment of their glycosylation sites using HILIC enrichment and partial deglycosylation.	ORM1 ORM2	3.39e-05	2	203	2	15253437
Pubmed	Selective binding of coumarin enantiomers to human alpha1-acid glycoprotein genetic variants.	ORM1 ORM2	3.39e-05	2	203	2	16290938
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	3.39e-05	2	203	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	3.39e-05	2	203	2	28621566
Pubmed	Retinoids increase alpha-1 acid glycoprotein expression at the transcriptional level through two distinct DR1 retinoic acid responsive elements.	ORM1 ORM2	3.39e-05	2	203	2	15157739
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	3.39e-05	2	203	2	32078638
Pubmed	Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of Multiple Sclerosis.	ORM1 ORM2	3.39e-05	2	203	2	37949310
Pubmed	Gamma-COP appendage domain - structure and function.	COPG1 ARFGAP2	3.39e-05	2	203	2	14690497
Pubmed	Comparison of alpha-1-acid glycoprotein isoforms from healthy and cancer patients by capillary IEF.	ORM1 ORM2	3.39e-05	2	203	2	17987628
Pubmed	The expression of Tousled kinases in CaP cell lines and its relation to radiation response and DSB repair.	TLK1 TLK2	3.39e-05	2	203	2	21647934
Pubmed	α1-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages.	ORM1 ORM2	3.39e-05	2	203	2	34210751
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	3.39e-05	2	203	2	23595828
Pubmed	Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization.	ORM1 ORM2	3.39e-05	2	203	2	37640741
Pubmed	An acute phase protein α1-acid glycoprotein mitigates AKI and its progression to CKD through its anti-inflammatory action.	ORM1 ORM2	3.39e-05	2	203	2	33846468
Pubmed	Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages.	IRF8 ZBTB46	3.39e-05	2	203	2	22615127
Pubmed	Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.	ORM1 ORM2	3.39e-05	2	203	2	28927749
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	3.39e-05	2	203	2	21621574
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	3.39e-05	2	203	2	28911206
Pubmed	α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice.	ORM1 ORM2	3.39e-05	2	203	2	22415874
Pubmed	Structure of 1 -acid glycoprotein. The complete amino acid sequence, multiple amino acid substitutions, and homology with the immunoglobulins.	ORM1 ORM2	3.39e-05	2	203	2	4711474
Pubmed	Structure and expression of the genes coding for human alpha 1-acid glycoprotein.	ORM1 ORM2	3.39e-05	2	203	2	2822385
Pubmed	Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation.	ORM1 ORM2	3.39e-05	2	203	2	20442402
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	3.39e-05	2	203	2	22875990
Pubmed	Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.	ORM1 ORM2	3.39e-05	2	203	2	25264156
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	3.39e-05	2	203	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	3.39e-05	2	203	2	15044002
Pubmed	Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres.	TLK1 TLK2	3.39e-05	2	203	2	32755577
Pubmed	Molecular characterization and acute phase expression of the multiple Mus caroli alpha 1-acid glycoprotein (AGP) genes. Differences in glucocorticoid stimulation and regulatory elements between the rat and mouse AGP genes.	ORM1 ORM2	3.39e-05	2	203	2	2354997
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	3.39e-05	2	203	2	22138648
Pubmed	cDNA cloning and chromosomal mapping of genes encoding novel protein kinases termed PKU-alpha and PKU-beta, which have nuclear localization signal.	TLK1 TLK2	3.39e-05	2	203	2	9427565
Pubmed	Structural heterogeneity of glycoform of alpha-1 Acid glycoprotein in alcoholic cirrhosis patients.	ORM1 ORM2	3.39e-05	2	203	2	25408356
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	3.39e-05	2	203	2	34220417
Pubmed	Nucleotide sequence of the mouse alpha 1-acid glycoprotein gene 1.	ORM1 ORM2	3.39e-05	2	203	2	3676251
Pubmed	Structure and characterisation of a duplicated human alpha 1 acid glycoprotein gene.	ORM1 ORM2	3.39e-05	2	203	2	2970990
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	3.39e-05	2	203	2	26241911
Pubmed	The disulfide bonds of alpha1-acid glycoprotein.	ORM1 ORM2	3.39e-05	2	203	2	4603214
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	3.39e-05	2	203	2	21446915
Pubmed	Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation.	ORM1 ORM2	3.39e-05	2	203	2	37853937
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	3.39e-05	2	203	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	3.39e-05	2	203	2	24593767
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	3.39e-05	2	203	2	37154294
Pubmed	A mouse gene family associated with a major submaxillary-gland glycoprotein.	ORM1 ORM2	3.39e-05	2	203	2	3977853
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	3.39e-05	2	203	2	22924626
Pubmed	Structure and expression of mouse alpha 1-acid glycoprotein gene-3 (AGP-3).	ORM1 ORM2	3.39e-05	2	203	2	1605854
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	3.39e-05	2	203	2	11032875
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	3.39e-05	2	203	2	29943084
Pubmed	High-resolution maps of the murine Chromosome 2 region containing the cholesterol gallstone locus, Lith1.	LRP2 ABCB11	3.39e-05	2	203	2	10556425
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	3.39e-05	2	203	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	3.39e-05	2	203	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	3.39e-05	2	203	2	27422263
Pubmed	Analysis of the five glycosylation sites of human alpha 1-acid glycoprotein.	ORM1 ORM2	3.39e-05	2	203	2	1567356
Pubmed	Plasma alpha-1-acid glycoprotein as a potential predictive biomarker for non-haematological adverse events of docetaxel in breast cancer patients.	ORM1 ORM2	3.39e-05	2	203	2	28554261
Pubmed	Genomic organization of profilin-III and evidence for a transcript expressed exclusively in testis.	PFN3 SLC34A1	3.39e-05	2	203	2	11867228
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	3.39e-05	2	203	2	15750346
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	3.39e-05	2	203	2	1711373
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	3.39e-05	2	203	2	20529287
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	3.39e-05	2	203	2	25124006
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	3.39e-05	2	203	2	23673664
Pubmed	Evidence for the existence of multiple alpha 1-acid glycoprotein genes in the mouse.	ORM1 ORM2	3.39e-05	2	203	2	3003086
Pubmed	Interaction of acute-phase-inducible and liver-enriched nuclear factors with the promoter region of the mouse alpha 1-acid glycoprotein gene-1.	ORM1 ORM2	3.39e-05	2	203	2	1371400
Pubmed	SILAC proteomics implicates SOCS1 in modulating cellular macromolecular complexes and the ubiquitin conjugating enzyme UBE2D involved in MET receptor tyrosine kinase downregulation.	MET SOCS1	3.39e-05	2	203	2	33493533
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	3.39e-05	2	203	2	39052831
Pubmed	Structure of human alpha1-acid glycoprotein and its high-affinity binding site.	ORM1 ORM2	3.39e-05	2	203	2	12480518
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	3.39e-05	2	203	2	24442550
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	3.39e-05	2	203	2	27137930
Pubmed	Orosomucoid in liver diseases.	ORM1 ORM2	3.39e-05	2	203	2	34963738
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	3.39e-05	2	203	2	26440896
Pubmed	Genetic variations of orosomucoid genes associated with serum alpha-1-acid glycoprotein level and the pharmacokinetics of paclitaxel in Japanese cancer patients.	ORM1 ORM2	3.39e-05	2	203	2	21638284
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	3.39e-05	2	203	2	12742085
Pubmed	Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1.	MET SOCS1	3.39e-05	2	203	2	29085209
Pubmed	Regulation of MET receptor tyrosine kinase signaling by suppressor of cytokine signaling 1 in hepatocellular carcinoma.	MET SOCS1	3.39e-05	2	203	2	25728680
Pubmed	A protective role of IL-30 via STAT and ERK signaling pathways in macrophage-mediated inflammation.	SOCS1 IL27	3.39e-05	2	203	2	23583238
Pubmed	The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.	ORM1 ORM2	3.39e-05	2	203	2	33168190
Pubmed	Mitigation of non-alcoholic steatohepatitis via recombinant Orosomucoid 2, an acute phase protein modulating the Erk1/2-PPARγ-Cd36 pathway.	ORM1 ORM2	3.39e-05	2	203	2	37355990
Pubmed	Molecular cloning of cDNAs corresponding to two genes of alpha 1-acid glycoprotein and characterization of two alleles of AGP-1 in the mouse.	ORM1 ORM2	3.39e-05	2	203	2	2475311
Pubmed	NLRP12 Promotes Mouse Neutrophil Differentiation through Regulation of Non-canonical NF-κB and MAPKERK1/2 Signaling.	NLRP12 MAP3K14	3.39e-05	2	203	2	29483833
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	3.39e-05	2	203	2	18688271
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	3.39e-05	2	203	2	22658952
Pubmed	A synthetic retinoic acid receptor agonist Am80 ameliorates renal fibrosis via inducing the production of alpha-1-acid glycoprotein.	ORM1 ORM2	3.39e-05	2	203	2	32651445
Pubmed	Regulation of MET receptor signaling by SOCS1 and its implications for hepatocellular carcinoma.	MET SOCS1	3.39e-05	2	203	2	23944359
Pubmed	Isoform differentiation of intact AGP from human serum by capillary electrophoresis-mass spectrometry.	ORM1 ORM2	3.39e-05	2	203	2	20617306
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	3.39e-05	2	203	2	38124277
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	3.39e-05	2	203	2	19015267
Pubmed	alpha 1-Acid glycoprotein binds human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein via N-linked glycans.	ORM1 ORM2	3.39e-05	2	203	2	7795416
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	3.39e-05	2	203	2	19448744
Pubmed	Investigation of genetic variants of alpha-1 acid glycoprotein by ultra-performance liquid chromatography-mass spectrometry.	ORM1 ORM2	3.39e-05	2	203	2	19018521
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	3.39e-05	2	203	2	11950837
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	ABCF1 BEND4 ME1 DDB1 KMT2C SARS1 AP3D1 ANK1 SLC4A1AP ZNF540 RBM34 KDM4B	3.98e-05	497	203	12	36774506
Pubmed	Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.	KCNU1 ATP10A CSMD1	4.15e-05	12	203	3	21901158
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	CHAF1B ABCF1 SMC1A DLGAP5 INTS3 PRDM2 EFTUD2 TLK1 ZNF644 TLK2 ZNF768 SLC4A1AP ARFGAP1 PROSER2 KDM4B	5.51e-05	774	203	15	15302935
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	SUSD6 PFKL FARP2 SARS1 TXNDC5 PTPRM ZNF101 FRMD4A FICD KDM4B	7.16e-05	371	203	10	15747579
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	SOCS6 PLEKHH1 KMT2C FDX2 TLK2 SEMA4F DNAH2 TEX28	7.31e-05	233	203	8	37704626
Interaction	LTBP2 interactions	ZNF444 ZNF696 ZNF358 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZNF749 ZNF324B ZNF646	7.44e-10	85	199	11	int:LTBP2
Interaction	EFEMP1 interactions	ZNF444 ZNF696 SOCS6 TXNDC5 ZNF358 E4F1 ZNF768 DDIAS ZNF646	3.72e-06	123	199	9	int:EFEMP1
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	NLRP12 ZNF444 ZNF154 RDH13 ZNF225 ZNF829 SPRED3 ZNF836 ZNF345 NPAS1 ZNF573 ZNF607 MEGF8 ZNF540 ZSCAN5C ZNF749 ZNF565 ZNF324B	6.85e-06	1192	203	18	chr19q13
Cytoband	19q13.12	ZNF829 ZNF345 ZNF573 ZNF540 ZNF565	1.77e-05	72	203	5	19q13.12
Cytoband	10q23.3	GLUD1 TNKS2	4.03e-04	7	203	2	10q23.3
Cytoband	19q13.43	ZNF444 ZSCAN5C ZNF749 ZNF324B	6.20e-04	87	203	4	19q13.43
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF133 ZNF444 ZNF140 ZNF672 ZNF154 ZNF696 ZNF225 ZNF829 ZNF836 WIZ ZNF358 ZNF345 ZNF311 ZNF573 ZNF607 E4F1 ZNF101 ZNF251 ZNF768 ZBTB46 ZNF517 ZNF540 ZSCAN5C ZNF749 ZFP92 ZSCAN16 ZNF565 ZNF324B ZNF333 ZNF700 ZNF646	2.99e-15	718	139	31	28
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NLRP12 KCNU1 ANK1 DNAH2 SLC34A1 LRP2 ARHGEF4 CSMD1	9.88e-07	167	202	8	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 PKHD1 ONECUT3 ANK1 HMCN1 LRP2 CSMD1 ST18	2.04e-06	184	202	8	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 PKHD1 ONECUT3 ANK1 HMCN1 LRP2 CSMD1 ST18	2.04e-06	184	202	8	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRV1 PKHD1 ONECUT3 ANK1 HMCN1 LRP2 CSMD1 ST18	2.04e-06	184	202	8	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Artery\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ADGRG1 MET PTPRG PTPRM GLUD1 MMP16 HMCN1 CSMD1	3.79e-06	200	202	8	ac9ead34afa14067171833f5c277eaf06db7b02e
ToppCell	P28-Epithelial-epithelial_progenitor_cell-epi_progenitor\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CHAF1B ME1 MET GGACT EGFL6 LRP2 ARHGEF4	7.03e-06	155	202	7	be575a0096415705dba425002247289ff8f89474
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GDPD1 FARP2 KMT2C TRPM5 PGGHG CSMD1 ST18	1.19e-05	168	202	7	8072d0496b7b730c4601009eaa69ec5366d26d73
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC10A4 MET PTPRM GRIN3A NPNT NPAS1 EGFL6	1.79e-05	179	202	7	c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP5 CHEK1 SOWAHC ME1 TLK1 FAM83D BEST1	1.86e-05	180	202	7	43fd5c498a87bb078d101298b472656f3294686a
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC10A4 METAP1D PTPRM GRIN3A NPAS1 ANK1 EGFL6	1.86e-05	180	202	7	b6efdb4d319ef6f87f559acd974e5a71b06a2322
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Rostral-�migratory_stream-�(RMS)_(Notum))\|Striatum / BrainAtlas - Mouse McCarroll V32	CHAF1B TNFSF9 RADX AOC2 PCSK4	2.04e-05	73	202	5	50a8164d967f2706344adcdc1562dc08c9f16c8f
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-type_II_pneumocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 ME1 MET SPDEF SEMA4F EGFL6 LRP2	2.63e-05	190	202	7	aaf5f1c1ff7b1454f4e5dacfeb48e1c3627e3372
ToppCell	droplet-Lung-immune-endo-depleted-3m-Epithelial-Alveolar_Epithelial_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG1 ME1 MET SPDEF SEMA4F EGFL6 LRP2	2.63e-05	190	202	7	a20123d5c6cb8c2f0dfd99bbfdb571a73c36234d
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery\|Children_(3_yrs) / Lineage, Cell type, age group and donor	GIPC2 PTPRG PTPRM MMP16 PPM1D HMCN1 CSMD1	2.63e-05	190	202	7	f6c38d197fd9d69a4f97cb2e72cd4747984c1a86
ToppCell	PCW_05-06-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADGRG1 ADGRV1 MET PKHD1 NPNT LLGL2 LRP2	2.72e-05	191	202	7	05731ece7867659c662f952812805f947032fe10
ToppCell	droplet-Heart-HEART_(ALL_4:4:4:1:1)-30m-Endothelial-endothelial_cell_of_coronary_artery\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DLGAP5 ADGRG1 PTPRG FSCN2 FAM83D DNAH2	2.98e-05	131	202	6	419a0a83b38eaea890d065c3f252ef83c2d37b5b
ToppCell	PBMC-Mild-cDC_4\|Mild / Compartment, Disease Groups and Clusters	ZNF154 ADGRG1 PLEKHH1 GUCY2D ZNF749 MAPKBP1	3.25e-05	133	202	6	e53fbd69775a4bff61de82557342f7ac80915c4d
ToppCell	(5)_Dendritic_cell-(54)_pDC\|(5)_Dendritic_cell / shred on Cell_type and subtype	IRF8 CYB561A3 ZNF251 SUSD1 ZNF540 SLITRK5 SNTA1	3.42e-05	198	202	7	fc6c6b60dddd7f2f997af0f87fae33f1c23f34a8
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_plasmacytoid\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	AIFM3 IRF8 ZNF101 ARFGAP1 ST18 IL27 ZNF646	3.42e-05	198	202	7	c64238379798ae6b292cc1914d60548c88e652de
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRV1 MET PTPRM NPNT LLGL2 LRP2 FAM20A	3.53e-05	199	202	7	725610310e5c5fd7120c0be9acb55bf152026ddd
Drug	methyl benzoquate	GLUD1 GLUD2 CYB561A3	2.78e-06	4	203	3	CID000026383
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	1.27e-04	3	193	2	DOID:885 (biomarker_via_orthology)
Disease	Neurodevelopmental Disorders	SMC1A KMT2C PPM1D MED13L CASK	3.71e-04	93	193	5	C1535926
Disease	prostate carcinoma (is_marker_for)	MET BMP4 SARS1	4.43e-04	23	193	3	DOID:10286 (is_marker_for)
Disease	laryngeal carcinoma (is_marker_for)	KMT2C SOCS1	6.27e-04	6	193	2	DOID:2600 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, multiple sclerosis	FCRL3 MAP3K14	6.27e-04	6	193	2	EFO_0004611, MONDO_0005301
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	6.27e-04	6	193	2	DOID:1825 (biomarker_via_orthology)
Disease	serine protease inhibitor Kazal-type 2 measurement	ORM1 ORM2	6.27e-04	6	193	2	EFO_0802054
Disease	blood chromium measurement	PTPRM ARHGEF4 HS6ST3	6.41e-04	26	193	3	EFO_0007579
Disease	cutaneous melanoma, hair color	GIPC2 ADGRV1 MED13L ATP10A	7.36e-04	62	193	4	EFO_0000389, EFO_0003924
Disease	blood urea nitrogen measurement	GIPC2 ADGRV1 BMP4 CLCNKB PKHD1 ZNF607 PPM1D SUSD1 SLC34A1 LRP2	8.36e-04	452	193	10	EFO_0004741
Disease	arachidonate 15-lipoxygenase B measurement	NLRP12 GUCY2D	8.75e-04	7	193	2	EFO_0801391
Disease	autosomal dominant polycystic kidney disease (biomarker_via_orthology)	SLC34A1 LRP2	8.75e-04	7	193	2	DOID:898 (biomarker_via_orthology)
Disease	hematocrit	SLC10A4 ADGRV1 PFKL ZNF829 MET CLCNKB PKHD1 NYAP1 AP3D1 ZNF345 TRMT112 DNAH2 FRMD4A SUSD1 SLC34A1 LRP2	1.05e-03	1011	193	16	EFO_0004348
Disease	protein-tyrosine sulfotransferase 2 measurement	NLRP12 PAFAH1B2	1.16e-03	8	193	2	EFO_0801971
Disease	melanoma	GIPC2 ADGRV1 FARP2 ZBTB46 SNTA1	1.46e-03	126	193	5	EFO_0000756
Disease	response to lamotrigine	GRIN3A CSMD1	1.49e-03	9	193	2	EFO_0007661
Disease	response to ondansetron, QT interval	MPDZ ARHGEF4	2.25e-03	11	193	2	EFO_0004682, EFO_0020997
Disease	coagulation factor XA measurement	ORM1 ORM2	2.25e-03	11	193	2	EFO_0020266
Disease	Mouth Diseases	CHAF1B GSS	2.69e-03	12	193	2	C0026636
Disease	physical activity	AEBP2 PKHD1 GRIN3A CSMD1	2.70e-03	88	193	4	EFO_0003940
Disease	squamous cell carcinoma, multiple keratinocyte carcinoma susceptibility measurement, basal cell carcinoma	PKHD1 CSMD1	3.17e-03	13	193	2	EFO_0000707, EFO_0004193, EFO_0007932
Disease	coagulation factor X measurement	ORM1 ORM2	3.17e-03	13	193	2	EFO_0020265
Disease	Leber congenital amaurosis (implicated_via_orthology)	RDH13 GUCY2D	3.17e-03	13	193	2	DOID:14791 (implicated_via_orthology)
Disease	Congenital pontocerebellar hypoplasia	RARS2 CASK	3.17e-03	13	193	2	C0266468
Disease	Hereditary Diffuse Gastric Cancer	TNFSF9 WDR46 DDB1 MET KMT2C PTPRG ARFGAP2	3.28e-03	293	193	7	C1708349
Disease	Stomach Neoplasms	TNFSF9 WDR46 DDB1 MET KMT2C PTPRG ARFGAP2	3.53e-03	297	193	7	C0038356
Disease	pneumonia	GIPC2 EXD3 IL27	3.62e-03	47	193	3	EFO_0003106
Disease	end stage renal disease (biomarker_via_orthology)	ACAT1 SLC34A1 LRP2	3.62e-03	47	193	3	DOID:783 (biomarker_via_orthology)
Disease	Malignant neoplasm of stomach	TNFSF9 WDR46 DDB1 MET KMT2C PTPRG ARFGAP2	3.73e-03	300	193	7	C0024623
Disease	Opioid use measurement	BEND4 AEBP2	4.23e-03	15	193	2	EFO_0009937
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	4.23e-03	15	193	2	DOID:13413 (biomarker_via_orthology)
Disease	Adenoid Cystic Carcinoma	SMC1A FGF16 KMT2C TLK1	4.27e-03	100	193	4	C0010606
Disease	galectin-3 measurement	NLRP12 DLGAP5	4.81e-03	16	193	2	EFO_0008137
Disease	monoclonal gammopathy	FRMD4A CSMD1 HS6ST3	5.08e-03	53	193	3	EFO_0000203
Disease	autosomal dominant intellectual developmental disorder (is_implicated_in)	TLK2 KDM4B	5.43e-03	17	193	2	DOID:0060307 (is_implicated_in)
Disease	Malignant mesothelioma	MET SEMA4F COPG1 ULK2	5.79e-03	109	193	4	C0345967
Disease	peptide measurement	TLK1 MMP16 ZNF573 CSMD1	5.79e-03	109	193	4	EFO_0010520
Disease	refractive error	METAP1D BMP4 GGACT NYAP1 FER1L4 GUCY2D ST18	5.83e-03	326	193	7	MONDO_0004892
Disease	alcoholic hepatitis (biomarker_via_orthology)	ABCB11 SOCS1	6.08e-03	18	193	2	DOID:12351 (biomarker_via_orthology)
Disease	sexual dimorphism measurement	GIPC2 CDC20B RAD54L2 FARP2 PTPRG SPDEF AP3D1 NPAS1 GSS ZBTB46 FER1L4 PAFAH1B2 MAPKBP1 SNTA1 IL27	6.31e-03	1106	193	15	EFO_0021796

Protein segments in the cluster

Peptide	Gene	Start	Entry
GALHENRHGSAVQIR	PTPRG	36	P23470
LGRFGLESHAHTIQI	ABCF1	726	Q8NE71
HIRSIHVDGQRGGVF	AEBP2	281	Q6ZN18
QHGAGVRHAGVQTSR	CDR2L	376	Q86X02
ARHHGLLASARQPGV	EGFL6	26	Q8IUX8
RAAVEVLRGHGLHSV	ANAPC2	56	Q9UJX6
NGHRHGGDFGIRSTV	CSMD1	881	Q96PZ7
AGVVYLHGIGITHRD	CHEK1	116	O14757
QGNGTARHFHTEERL	AIFM3	41	Q96NN9
SLVSGHQRGQARITH	ANK1	1671	P16157
THRLHLNRFSVSGTG	GRM3	836	Q14832
GGREHVAHLLFLRDT	ORM2	111	P19652
VGHARQGRAVGTFLH	BEND4	491	Q6ZU67
ANITVRRSGGHFGRL	ADGRV1	2371	Q8WXG9
NAFRLHRGATGDSHL	ARHGEF4	571	Q9NR80
FQHGTAGRIHRLASA	CHAF1B	21	Q13112
IIGFEHGTAVERGTH	ABCB11	626	O95342
SGRHRGLGVHLSFVR	ARFGAP1	46	Q8N6T3
RLVFHAQLAHGSATG	GIPC2	41	Q8TF65
HAGIIGRFLGLQSHD	BEST1	386	O76090
GVHRSLGVHLSFIRS	ARFGAP2	51	Q8N6H7
TFHTRIGGDLTHGII	APRG1	31	Q8IVJ8
RHSGIGHGQASSAVR	FLG	2666	P20930
HSFNSFRLRVGINHG	ADCY7	981	P51828
LHSLLEGFVQRRGHT	RAD54L2	551	Q9Y4B4
FPRARLAAIGSTHGH	C1orf147	76	Q96MC9
HAGGRRSGQSHELLR	BMP4	41	P12644
RGSIGSHQSVRVVHR	ATP10A	481	O60312
TRLEGTRHGHLIAAQ	AP3D1	426	O14617
LVTGAGRGHAGRIIH	RAB3GAP1	881	Q15042
GRGHAGRIIHKLFVN	RAB3GAP1	886	Q15042
GQVASSLFRGEHHSR	RBM34	36	P42696
EHHSRGGTGRLASLF	RBM34	46	P42696
AFGTIAIQLAHHRGA	CRYZL1	156	O95825
GHVRQGVFSSLNHIV	INTS3	451	Q68E01
HVTGRLRAHALGLVA	NPAS1	271	Q99742
GCTVDVNHFGAHVRR	SLC10A4	121	Q96EP9
RSLGHFEVTILGLNH	RADX	746	Q6NSI4
LHRAVGHFELRKNGT	ASB8	211	Q9H765
RVGERVLGTVHTHAF	AOC2	506	O75106
GAHGVGRRHIKNTLI	CASK	746	O14936
HTFRVGSLIFHTIGQ	KMT2C	4546	Q8NEZ4
RGLFITIHDRGHIAS	ME1	121	P48163
GVHLLVRRGSHRIFS	METAP1D	6	Q6UB28
GVGSHFQHSRSQGER	MED13L	2066	Q71F56
GTSHGFGLFDHQQRR	LLGL2	606	Q6P1M3
VGSFLHRVGARVPHA	MFHAS1	516	Q9Y4C4
RHKVTGLHSGTLQVF	NPNT	486	Q6UXI9
GLHSGTLQVFVRKHG	NPNT	491	Q6UXI9
RSSHVGSGPRVVAHF	NUDT16	96	Q96DE0
GRFVLKITDHGHGRL	GUCY2D	676	Q02846
VHRGGHFDTPVQFLR	HECA	331	Q9UBI9
RLGSSLRHGIGHIEA	KCNK4	141	Q9NYG8
LHTIVRGFIHSAVGG	SLC43A2	456	Q8N370
HVRQQHLRAGGAAAS	FAM43B	216	Q6ZT52
AGRFRTTQVLVGHHI	FICD	306	Q9BVA6
IERRAFGHTVLVGSH	FER1L4	1011	A9Z1Z3
AFVHRCGRTARIGHG	DDX55	351	Q8NHQ9
HVGVGHSGNITRIRI	CFAP52	581	Q8N1V2
SGRVGDNVLHLAQRH	FDX2	86	Q6P4F2
RFFNHTRLVTAGPGH	PCSK4	626	Q6UW60
GTRITIHGNDLHVGS	PLXND1	996	Q9Y4D7
FGHLERGVLLHSSRQ	IRF8	271	Q02556
VENGNGRRHASVLLH	IL1RAPL1	336	Q9NZN1
AAVRSAVRTGISHGH	PFKL	416	P17858
VSLTHHVGLRRAGVL	PDE3B	496	Q13370
PISGFHQTRIHGINR	DDIAS	776	Q8IXT1
RRTLFTENHLGLHSG	FAM83D	551	Q9H4H8
HGGHRPSTARFSVRV	MEGF8	406	Q7Z7M0
HKSGGHAVQLLRAVS	KDM4B	906	O94953
NHRVLRDGAHGSAAF	GGACT	16	Q9BVM4
QRFLSKHISHRGGAG	GDPD1	36	Q8N9F7
GTIARSHVRSLHFQG	KCNU1	71	A8MYU2
HSTFDGLDRRRLGHI	LRP2	896	P98164
LGTRVFHDTLHVSGV	PGGHG	31	Q32M88
GHGGREAAQFAREHL	PPM1D	106	O15297
LAHGTTTLAFRFRHG	PSMB11	46	A5LHX3
RAHLAADRHGGSVQV	CSNK1G3	381	Q9Y6M4
LHIQKTGGTTFGRHL	HS6ST3	151	Q8IZP7
GVARTELGRHTGIHG	RDH13	231	Q8NBN7
GFLHIQSAHVTDTGR	HMCN1	3766	Q96RW7
HREGTFNHTLRLIGE	KIR2DS5	61	Q14953
HHPSQGFRFGTVRES	GRIN3A	786	Q8TCU5
HITRLVVASFNIHGG	SLC34A1	246	Q06495
RHTFLQAGLSVGGRR	PFN3	56	P60673
SVTRRTFGHSGIAVH	FRMD4A	281	Q9P2Q2
GRSHNRGSRTGYVHI	KLHL22	551	Q53GT1
HGRISATGRGVFHGI	GLUD1	266	P00367
ARSVGRSAHIQASGH	CENPT	66	Q96BT3
VRGQAHRFAESHLPG	IL27	61	Q8NEV9
RHQEHARHISFGGNL	DLGAP5	821	Q15398
LLFLVQGAHGRGHRE	ADGRG1	16	Q9Y653
EIHQAGGGIHFTVER	AMDHD1	111	Q96NU7
GLGAQHSHGVSLRVT	FCRL3	456	Q96P31
FQGNTIHLRGTHRDS	HEPHL1	661	Q6MZM0
RTLGLFQHHDAITGT	MAN2A2	561	P49641
SGDGVQFTRTHHVVR	MAPKBP1	601	O60336
GGQEHFAHLLILRDT	ORM1	111	P02763
RSGGFFGHRGRVLHL	CDC20B	481	Q86Y33
GHRANRTVPGAHSRL	GPR156	621	Q8NFN8
RTVPGAHSRLHVQNG	GPR156	626	Q8NFN8
DAVTVHSTHGGFLIR	CRIPAK	416	Q8N1N5
GILSGHVHDRGQVFV	GLB1L2	441	Q8IW92
HTLLLAGVFRGGHDI	COPG1	826	Q9Y678
VGLVAVFTFHNHGRT	CYB561A3	96	Q8NBI2
GRGFAEHGTLNRHLR	E4F1	581	Q66K89
SFGGLASRTPAVHRH	GSS	151	P48637
RGVRSSLEGHGQHRA	FARP2	891	O94887
GARTQHFRGHTGAVF	FBXW2	216	Q9UKT8
FHKNLHTLRAVRGGI	DNAH2	431	Q9P225
SLRIIRNGIGIHEHA	DDB1	386	Q16531
HGRISATGRGVFHGI	GLUD2	266	P49448
VTIQGGAHHLDLRAS	DPP7	436	Q9UHL4
DLSEHRFLLHGVGNI	PRDM2	1176	Q13029
LHALNFGIGGDTTRH	PAFAH1B2	66	P68402
GVHEIREIRQFHFTG	PTPRM	1046	P28827
THQLRLGRGSFGEVH	MAP3K14	401	Q99558
GHARSAAAQHRGLVA	ONECUT3	26	O60422
VRSQGAEGLLARIHH	NYAP1	681	Q6ZVC0
LRGLDGFVCHHRGSN	FSCN2	386	O14926
LIVHFNEVIGRGHFG	MET	1076	P08581
TGRTHQIRVHLQFLG	RPUSD2	366	Q8IZ73
GSHGRDTRGIFRVHQ	SARS1	306	P49591
HVGHLRSTIIGNFIA	RARS2	141	Q5T160
VTSGFSRIGHIAHLN	TRMT5	196	Q32P41
FALRTGTRHGVDTHL	SNTA1	366	Q13424
IDLNSTHGTFLGHIR	PPP1R8	86	Q12972
GTEDGHLHRAVRIGA	SEMA4F	456	O95754
RRAQVLATIHGHAGA	PROSER2	281	Q86WR7
LIHLDNARGFGRHSH	FAM20A	426	Q96MK3
FPNGTVHGTRHDHSR	FGF16	76	O43320
FETHGTARVAQGHLL	MRGPRG-AS1	36	Q2M3A8
GARIVGHLTHALKQG	ACAT1	391	P24752
VIDGIRTGQHRSLFH	TUBAL3	81	A6NHL2
LANHVRGHLNRVGVS	WIZ	716	O95785
LHGNVVAGSERLGFH	PKHD1	3091	P08F94
VAGSERLGFHIRGHK	PKHD1	3096	P08F94
GGRALHAELVQHFRG	SOWAHC	26	Q53LP3
HAELVQHFRGALGGE	SOWAHC	31	Q53LP3
LKSFHHSRRDQGVSG	SUSD6	146	Q92537
IRVHFQAGRFHLDGS	SOCS1	126	O15524
VHDVRLNGSAAGHVL	TENT5C	66	Q5VWP2
GLGHVNNVFVTHRSL	ST18	876	O60284
QDRLRLGHFTTVRHG	TLK2	291	Q86UE8
LGRNIGSHRVRVEHF	CLCNKB	536	P51801
HAADRGERGHFGVQI	LINC02915	151	Q8N8G6
DRLRLGHFTTVRHGA	TLK1	296	Q9UKI8
FRHLADHGQLSGIQR	MRPS14	111	O60783
GRSGLSQHRRVHSGE	ZFP92	331	A6NM28
AFRSASQLRVHGGTH	ZNF700	426	Q9H0M5
SRRGQFTEHQKIHTG	ZNF540	561	Q8NDQ6
HQRIHGRAAASAQGA	ZNF444	296	Q8N0Y2
GSQLTVHRRIHTGAR	ZNF565	331	Q8N9K5
GKGFIHSSEVTRHQR	ZNF565	381	Q8N9K5
GDFHVINGVLRTAHS	CSE1L	141	P55060
FHVRATLPHFRGGET	nan	86	Q6ZSR3
SFTLGRHQRVHTGER	ZNF749	366	O43361
SQGGHLRIHQRVHTG	ZNF573	256	Q86YE8
GLARHVGQAVRDHSL	TRPM5	111	Q9NZQ8
GISLEATVGHHFIRS	MPDZ	566	O75970
FSTGRRLDFVHHSGV	MMP16	6	P51512
ETGAFHGLRGLRRLH	SLITRK5	121	O94991
HNLLSSHVRGVGSRG	TRMT112	6	Q9UI30
FQVAARLGHHRGLLE	THEM5	6	Q8N1Q8
FRQRSPLGGDVLHAH	SPDEF	191	O95238
GGARQGHYVIHGERL	SPRED3	41	Q2MJR0
RHAILVGNHSSRLGG	SUSD1	246	Q6UWL2
AFRSGAGLRSHARIH	ZNF672	171	Q499Z4
GFGQRSDLVVHQRIH	ZNF672	291	Q499Z4
SRHGLQHEGIFRVSG	SRGAP2	516	O75044
VYGRLSRHQSIHTGE	ZNF607	236	Q96SK3
GKAFSVHGRLTRHQG	ZNF607	371	Q96SK3
RGSVHFGLVRLIHGE	UBE2O	71	Q9C0C9
GRGSTLIQHQRIHTG	ZNF768	271	Q9H5H4
RALSGFFRHQRLHTG	ZNF696	331	Q9H7X3
GSLVNHRRTHETGLF	ZNF646	61	O15015
LHDGIQRVLFGHGLS	NDST2	271	P52849
RRIAFGGHQRHKTVA	SMC1A	626	Q14683
GGHQRHKTVALDGTL	SMC1A	631	Q14683
PLLTQRGSGEARHHF	TTLL3	556	Q9Y4R7
TGRHLAFGGRRGHVA	WDR46	206	O15213
QVGHGHFGRVVNIET	PLEKHH1	336	Q9ULM0
LSAGQRLGVHLHTEA	TNFSF9	206	P41273
FGHAEVVNLLLRHGA	TNKS2	101	Q9H2K2
AFGSRSDLIRHEGIH	ZNF829	416	Q3KNS6
RFTLNEHGRIHSGER	ZNF517	301	Q6ZMY9
GRAFGQSSHLIVHVR	ZNF333	596	Q96JL9
GLSRHVRVHSGETTF	ZNF225	386	Q9UK10
ECGRGFSHQAGLIRH	ZNF133	526	P52736
TFETGVGLSNHVRGH	ZNF644	971	Q9H582
GHGAFAVVFRGRHRQ	ULK2	16	Q8IYT8
AGLTGFHVVLVARGR	ZDHHC5	201	Q9C0B5
GFGSLAGSVHVRIRR	SLC30A6	291	Q6NXT4
GRAFGFNSHLTEHVR	ZNF251	411	Q9BRH9
LHERTHLAGRSQCFG	ZNF101	411	Q8IZC7
FSGRTGLIQHQRIHT	ZSCAN16	301	Q9H4T2
GRRFSLVLHQRTHTG	ZNF140	171	P52738
HSGGRDLDSLHRFVL	TXNDC5	411	Q8NBS9
HVGPRLRGETAFAFH	SLX1A	96	Q9BQ83
QRSALLQHRGVHTGE	ZNF154	256	Q13106
RSALLQHRGVHTGER	ZNF154	341	Q13106
GGLAHNLQDSVRHRI	TEX28	41	O15482
SFGSGLIRHQIIHSG	ZNF345	156	Q14585
HAFGRVLSGTIHAGQ	EFTUD2	491	Q15029
RIGLQFHQRTHTGER	ZSCAN5C	396	A6NGD5
GKTLHTRIEHSNGRF	SOCS6	426	O14544
GTRSQVEPLFTHRGH	WDR73	316	Q6P4I2
VLGVFNHVHFGQRHR	TCIRG1	551	Q13488
AASVGIRHGSRRHGV	ZBTB46	486	Q86UZ6
GKVFSQTSHLVGHRR	ZNF836	476	Q6ZNA1
HTRGVYHFSIQGRTV	TMEM249	116	Q2WGJ8
SFRQGSALIGHKRVH	ZNF311	591	Q5JNZ3
GATLAQHRGIHTGAR	ZNF358	191	Q9NW07
GFAKGAVLLSHRRIH	ZNF324B	461	Q6AW86
LLDTGRGHARTVGHQ	NLRP12	176	P59046
LHHEGRFREAATLGA	EXD3	146	Q8N9H8
RVHVGHVVRFGGSTR	SLC4A1AP	256	Q9BWU0