Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	IQCA1L MYH6 DNAH12 VWA8 MYO9A ATAD3A SMARCA2 SMARCA4 PSMC5 RNF213 SRPRA KATNA1 KIF1C	4.03e-08	614	62	13	GO:0140657
GeneOntologyMolecularFunction	ATP hydrolysis activity	IQCA1L DNAH12 VWA8 ATAD3A SMARCA4 PSMC5 RNF213 SRPRA KATNA1 KIF1C	9.61e-07	441	62	10	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	IQCA1L DNAH12 VWA8 ATAD3A SMARCA4 PSMC5 RNF213 SRPRA KATNA1 ARF1 ARF3 KIF1C	3.89e-06	775	62	12	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	IQCA1L DNAH12 VWA8 ATAD3A SMARCA4 PSMC5 RNF213 SRPRA KATNA1 ARF1 ARF3 KIF1C	8.71e-06	839	62	12	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	IQCA1L DNAH12 VWA8 ATAD3A SMARCA4 PSMC5 RNF213 SRPRA KATNA1 ARF1 ARF3 KIF1C	8.82e-06	840	62	12	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	IQCA1L DNAH12 VWA8 ATAD3A SMARCA4 PSMC5 RNF213 SRPRA KATNA1 ARF1 ARF3 KIF1C	8.82e-06	840	62	12	GO:0016818
GeneOntologyMolecularFunction	JUN kinase binding	LMNB1 MAP3K1 MAPK8IP3	1.88e-05	17	62	3	GO:0008432
GeneOntologyMolecularFunction	microtubule severing ATPase activity	IQCA1L KATNA1	3.37e-04	9	62	2	GO:0008568
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYH6 DNAH12 MYO9A KIF1C	4.96e-04	118	62	4	GO:0003774
GeneOntologyMolecularFunction	protein-containing complex destabilizing activity	IQCA1L KATNA1	9.70e-04	15	62	2	GO:0140776
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase binding	MAP3K1 MAPK8IP3	1.57e-03	19	62	2	GO:0031434
GeneOntologyMolecularFunction	isomerase activity	RPUSD3 L3HYPDH KATNA1 PPWD1	2.99e-03	192	62	4	GO:0016853
GeneOntologyCellularComponent	bBAF complex	SMARCA2 SMARCA4	3.96e-04	10	63	2	GO:0140092
GeneOntologyCellularComponent	chylomicron	APOE APOBR	6.82e-04	13	63	2	GO:0042627
GeneOntologyCellularComponent	npBAF complex	SMARCA2 SMARCA4	7.95e-04	14	63	2	GO:0071564
GeneOntologyCellularComponent	GBAF complex	SMARCA2 SMARCA4	7.95e-04	14	63	2	GO:0140288
GeneOntologyCellularComponent	nBAF complex	SMARCA2 SMARCA4	1.04e-03	16	63	2	GO:0071565
GeneOntologyCellularComponent	low-density lipoprotein particle	APOE APOBR	1.04e-03	16	63	2	GO:0034362
Domain	P-loop_NTPase	MYH6 DNAH12 VWA8 MYO9A ATAD3A YLPM1 SMARCA2 SMARCA4 PSMC5 RNF213 SRPRA KATNA1 ARF1 ARF3 KIF1C	1.01e-07	848	63	15	IPR027417
Domain	AAA+_ATPase	DNAH12 VWA8 ATAD3A PSMC5 RNF213 SRPRA KATNA1	5.40e-07	144	63	7	IPR003593
Domain	AAA	DNAH12 VWA8 ATAD3A PSMC5 RNF213 SRPRA KATNA1	5.40e-07	144	63	7	SM00382
Domain	-	DNAH12 VWA8 ATAD3A YLPM1 SMARCA2 SMARCA4 PSMC5 RNF213 SRPRA KATNA1 ARF1 ARF3	6.19e-06	746	63	12	3.40.50.300
Domain	SnAC	SMARCA2 SMARCA4	1.12e-05	2	63	2	SM01314
Domain	Gln-Leu-Gln_QLQ	SMARCA2 SMARCA4	1.12e-05	2	63	2	IPR014978
Domain	SnAC	SMARCA2 SMARCA4	1.12e-05	2	63	2	IPR029295
Domain	SnAC	SMARCA2 SMARCA4	1.12e-05	2	63	2	PF14619
Domain	QLQ	SMARCA2 SMARCA4	1.12e-05	2	63	2	SM00951
Domain	QLQ	SMARCA2 SMARCA4	1.12e-05	2	63	2	PS51666
Domain	QLQ	SMARCA2 SMARCA4	1.12e-05	2	63	2	PF08880
Domain	HSA	SMARCA2 SMARCA4	6.69e-05	4	63	2	SM00573
Domain	HSA	SMARCA2 SMARCA4	6.69e-05	4	63	2	PS51204
Domain	HSA_dom	SMARCA2 SMARCA4	6.69e-05	4	63	2	IPR014012
Domain	HSA	SMARCA2 SMARCA4	6.69e-05	4	63	2	PF07529
Domain	BEX	BEX1 BEX5	1.11e-04	5	63	2	IPR007623
Domain	BRK	SMARCA2 SMARCA4	1.67e-04	6	63	2	SM00592
Domain	BRK_domain	SMARCA2 SMARCA4	1.67e-04	6	63	2	IPR006576
Domain	BRK	SMARCA2 SMARCA4	1.67e-04	6	63	2	PF07533
Domain	AAA	VWA8 PSMC5 KATNA1	2.03e-04	34	63	3	PS00674
Domain	AAA	ATAD3A PSMC5 KATNA1	7.18e-04	52	63	3	PF00004
Domain	ATPase_AAA_core	ATAD3A PSMC5 KATNA1	8.03e-04	54	63	3	IPR003959
Domain	TF_A-like/BEX	BEX1 BEX5	9.93e-04	14	63	2	IPR021156
Domain	ATPase_dyneun-rel_AAA	DNAH12 VWA8	9.93e-04	14	63	2	IPR011704
Domain	BEX	BEX1 BEX5	9.93e-04	14	63	2	PF04538
Domain	AAA_5	DNAH12 VWA8	9.93e-04	14	63	2	PF07728
Domain	Bromodomain_CS	SMARCA2 SMARCA4	3.45e-03	26	63	2	IPR018359
Domain	ATPase_AAA_CS	PSMC5 KATNA1	4.29e-03	29	63	2	IPR003960
Domain	ARF	ARF1 ARF3	4.29e-03	29	63	2	PS51417
Domain	Small_GTPase_ARF	ARF1 ARF3	4.29e-03	29	63	2	IPR024156
Domain	FHA_DOMAIN	PHLDB1 KIF1C	4.89e-03	31	63	2	PS50006
Domain	FHA	PHLDB1 KIF1C	4.89e-03	31	63	2	PF00498
Domain	Arf	ARF1 ARF3	4.89e-03	31	63	2	PF00025
Domain	SNF2_N	SMARCA2 SMARCA4	5.20e-03	32	63	2	IPR000330
Domain	SNF2_N	SMARCA2 SMARCA4	5.20e-03	32	63	2	PF00176
Domain	Small_GTPase_ARF/SAR	ARF1 ARF3	5.53e-03	33	63	2	IPR006689
Domain	FHA_dom	PHLDB1 KIF1C	6.55e-03	36	63	2	IPR000253
Domain	-	PHLDB1 KIF1C	6.55e-03	36	63	2	2.60.200.20
Domain	BROMODOMAIN_1	SMARCA2 SMARCA4	6.91e-03	37	63	2	PS00633
Domain	Myosin_head_motor_dom	MYH6 MYO9A	7.28e-03	38	63	2	IPR001609
Domain	Bromodomain	SMARCA2 SMARCA4	7.28e-03	38	63	2	PF00439
Domain	MYOSIN_MOTOR	MYH6 MYO9A	7.28e-03	38	63	2	PS51456
Pubmed	The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells.	FLT1 SHC2 ATR	5.93e-08	5	64	3	10749680
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	MFAP1 LMNB1 ATAD3A CEP250 SMARCA2 INTS3 CSTF2T NCOA5	2.11e-07	340	64	8	29478914
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	MFAP1 FADS1 PAXBP1 LMNB1 ATR ATAD3A NUDT21 YLPM1 SMARCA4 SRPRA INTS3 SPTY2D1 NCOA5	5.54e-07	1294	64	13	30804502
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	MFAP1 PAXBP1 ATR ZNF516 YLPM1 SMARCA2 SMARCA4 INTS3 CSTF2T MAPK8IP3	1.44e-06	774	64	10	15302935
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	FADS1 CMTR1 VWA8 ATAD3A NUDT21 RPUSD3 SMARCA4 HKDC1 RNF213 SRPRA ALAD COLGALT1 ARF3	1.98e-06	1451	64	13	30550785
Pubmed	BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease.	MYH6 SMARCA2 SMARCA4	2.66e-06	15	64	3	28737171
Pubmed	The hbrm and BRG-1 proteins, components of the human SNF/SWI complex, are phosphorylated and excluded from the condensed chromosomes during mitosis.	SMARCA2 SMARCA4	3.33e-06	2	64	2	8670841
Pubmed	Lung cancer with loss of BRG1/BRM, shows epithelial mesenchymal transition phenotype and distinct histologic and genetic features.	SMARCA2 SMARCA4	3.33e-06	2	64	2	23163725
Pubmed	Molecular cloning, characterization, and expression of human ADP-ribosylation factors: two guanine nucleotide-dependent activators of cholera toxin.	ARF1 ARF3	3.33e-06	2	64	2	2474826
Pubmed	Combined gene dosage requirement for SWI/SNF catalytic subunits during early mammalian development.	SMARCA2 SMARCA4	3.33e-06	2	64	2	23076393
Pubmed	The SWI/SNF chromatin remodeling protein Brg1 is required for vertebrate neurogenesis and mediates transactivation of Ngn and NeuroD.	SMARCA2 SMARCA4	3.33e-06	2	64	2	15576411
Pubmed	Chromatin remodeling factors and BRM/BRG1 expression as prognostic indicators in non-small cell lung cancer.	SMARCA2 SMARCA4	3.33e-06	2	64	2	15240517
Pubmed	Concomitant loss of SMARCA2 and SMARCA4 expression in small cell carcinoma of the ovary, hypercalcemic type.	SMARCA2 SMARCA4	3.33e-06	2	64	2	26564006
Pubmed	SMARCA4/SMARCA2-deficient Carcinoma of the Esophagus and Gastroesophageal Junction.	SMARCA2 SMARCA4	3.33e-06	2	64	2	33027072
Pubmed	A synthetic lethality-based strategy to treat cancers harboring a genetic deficiency in the chromatin remodeling factor BRG1.	SMARCA2 SMARCA4	3.33e-06	2	64	2	23872584
Pubmed	Alterations of the SWI/SNF chromatin remodelling subunit-BRG1 and BRM in hepatocellular carcinoma.	SMARCA2 SMARCA4	3.33e-06	2	64	2	23088494
Pubmed	SWI/SNF chromatin remodeling enzyme ATPases promote cell proliferation in normal mammary epithelial cells.	SMARCA2 SMARCA4	3.33e-06	2	64	2	20333683
Pubmed	SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies.	SMARCA2 SMARCA4	3.33e-06	2	64	2	34812766
Pubmed	Targeting of BRM Sensitizes BRG1-Mutant Lung Cancer Cell Lines to Radiotherapy.	SMARCA2 SMARCA4	3.33e-06	2	64	2	30478150
Pubmed	The SWI/SNF ATPases Are Required for Triple Negative Breast Cancer Cell Proliferation.	SMARCA2 SMARCA4	3.33e-06	2	64	2	25808524
Pubmed	Antagonistic roles for BRM and BRG1 SWI/SNF complexes in differentiation.	SMARCA2 SMARCA4	3.33e-06	2	64	2	19144648
Pubmed	High expression of SMARCA4 or SMARCA2 is frequently associated with an opposite prognosis in cancer.	SMARCA2 SMARCA4	3.33e-06	2	64	2	29391527
Pubmed	Expression of SMARCA2 and SMARCA4 in gastric adenocarcinoma and construction of a nomogram prognostic model.	SMARCA2 SMARCA4	3.33e-06	2	64	2	37634210
Pubmed	Two human homologues of Saccharomyces cerevisiae SWI2/SNF2 and Drosophila brahma are transcriptional coactivators cooperating with the estrogen receptor and the retinoic acid receptor.	SMARCA2 SMARCA4	3.33e-06	2	64	2	8208605
Pubmed	A Brg1 null mutation in the mouse reveals functional differences among mammalian SWI/SNF complexes.	SMARCA2 SMARCA4	3.33e-06	2	64	2	11163203
Pubmed	Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes.	SMARCA2 SMARCA4	3.33e-06	2	64	2	12620226
Pubmed	BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo.	SMARCA2 SMARCA4	3.33e-06	2	64	2	27039070
Pubmed	Partial Inactivation of the Chromatin Remodelers SMARCA2 and SMARCA4 in Virus-Infected Cells by Caspase-Mediated Cleavage.	SMARCA2 SMARCA4	3.33e-06	2	64	2	29848589
Pubmed	Characterization of the human gene encoding ADP-ribosylation factor 1, a guanine nucleotide-binding activator of cholera toxin.	ARF1 ARF3	3.33e-06	2	64	2	1577740
Pubmed	Assignment of human ADP ribosylation factor (ARF) genes ARF1 and ARF3 to chromosomes 1q42 and 12q13, respectively.	ARF1 ARF3	3.33e-06	2	64	2	8661066
Pubmed	Differential preimplantation regulation of two mouse homologues of the yeast SWI2 protein.	SMARCA2 SMARCA4	3.33e-06	2	64	2	9603422
Pubmed	SWI/SNF gene variants and glioma risk and outcome.	SMARCA2 SMARCA4	3.33e-06	2	64	2	23276717
Pubmed	Differential Expression of SWI/SNF Chromatin Remodeler Subunits Brahma and Brahma-Related Gene During Drug-Induced Liver Injury and Regeneration in Mouse Model.	SMARCA2 SMARCA4	3.33e-06	2	64	2	27097303
Pubmed	SMARCA4 and SMARCA2 deficiency in non-small cell lung cancer: immunohistochemical survey of 316 consecutive specimens.	SMARCA2 SMARCA4	3.33e-06	2	64	2	28038711
Pubmed	Proinflammatory stimuli engage Brahma related gene 1 and Brahma in endothelial injury.	SMARCA2 SMARCA4	3.33e-06	2	64	2	23963727
Pubmed	SW13 cells can transition between two distinct subtypes by switching expression of BRG1 and Brm genes at the post-transcriptional level.	SMARCA2 SMARCA4	3.33e-06	2	64	2	12493776
Pubmed	Heterozygous Mutations in SMARCA2 Reprogram the Enhancer Landscape by Global Retargeting of SMARCA4.	SMARCA2 SMARCA4	3.33e-06	2	64	2	31375262
Pubmed	Aberrant expression of SWI/SNF catalytic subunits BRG1/BRM is associated with tumor development and increased invasiveness in prostate cancers.	SMARCA2 SMARCA4	3.33e-06	2	64	2	17075831
Pubmed	Loss of SWI/SNF Chromatin Remodeling Alters NRF2 Signaling in Non-Small Cell Lung Carcinoma.	SMARCA2 SMARCA4	3.33e-06	2	64	2	32855269
Pubmed	ALAD and APOE polymorphisms are associated with lead and mercury levels in Italian pregnant women and their newborns with adequate nutritional status of zinc and selenium.	ALAD APOE	3.33e-06	2	64	2	36621546
Pubmed	Downregulation of SWI/SNF chromatin remodeling factor subunits modulates cisplatin cytotoxicity.	SMARCA2 SMARCA4	3.33e-06	2	64	2	22721696
Pubmed	Chromatin remodeling complexes interact dynamically with a glucocorticoid receptor-regulated promoter.	SMARCA2 SMARCA4	3.33e-06	2	64	2	18508913
Pubmed	Compensation of BRG-1 function by Brm: insight into the role of the core SWI-SNF subunits in retinoblastoma tumor suppressor signaling.	SMARCA2 SMARCA4	3.33e-06	2	64	2	11719516
Pubmed	Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque.	FADS1 APOE	3.33e-06	2	64	2	27382320
Pubmed	DNA binding drives the association of BRG1/hBRM bromodomains with nucleosomes.	SMARCA2 SMARCA4	3.33e-06	2	64	2	28706277
Pubmed	[Expression of BRG1 and BRM proteins in prostatic cancer].	SMARCA2 SMARCA4	3.33e-06	2	64	2	21092585
Pubmed	ARF1 and ARF3 are required for the integrity of recycling endosomes and the recycling pathway.	ARF1 ARF3	3.33e-06	2	64	2	22971977
Pubmed	SWI/SNF Complex-deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract: A Series of 13 Cases Highlighting Mutually Exclusive Loss of SMARCA4 and SMARCA2 and Frequent Co-inactivation of SMARCB1 and SMARCA2.	SMARCA2 SMARCA4	3.33e-06	2	64	2	26551623
Pubmed	SWI/SNF deficiency results in aberrant chromatin organization, mitotic failure, and diminished proliferative capacity.	SMARCA2 SMARCA4	3.33e-06	2	64	2	19458193
Pubmed	The Bromodomains of the mammalian SWI/SNF (mSWI/SNF) ATPases Brahma (BRM) and Brahma Related Gene 1 (BRG1) promote chromatin interaction and are critical for skeletal muscle differentiation.	SMARCA2 SMARCA4	3.33e-06	2	64	2	34289068
Pubmed	SMARCA4/2 loss inhibits chemotherapy-induced apoptosis by restricting IP3R3-mediated Ca2+ flux to mitochondria.	SMARCA2 SMARCA4	3.33e-06	2	64	2	34518526
Pubmed	SMARCA family of genes.	SMARCA2 SMARCA4	3.33e-06	2	64	2	32312722
Pubmed	Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.	SMARCA2 SMARCA4	3.33e-06	2	64	2	26356327
Pubmed	Loss of BRG1/BRM in human lung cancer cell lines and primary lung cancers: correlation with poor prognosis.	SMARCA2 SMARCA4	3.33e-06	2	64	2	12566296
Pubmed	SMARCA2-deficiency confers sensitivity to targeted inhibition of SMARCA4 in esophageal squamous cell carcinoma cell lines.	SMARCA2 SMARCA4	3.33e-06	2	64	2	31406271
Pubmed	Co-regulation of transcription by BRG1 and BRM, two mutually exclusive SWI/SNF ATPase subunits.	SMARCA2 SMARCA4	3.33e-06	2	64	2	29273066
Pubmed	Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.	LMNB1 NUDT21 SMARCA2 SMARCA4 ARF3	4.48e-06	131	64	5	34551306
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	MFAP1 PAXBP1 LMNB1 VWA8 NUDT21 RPUSD3 YLPM1 SMARCA4 SRPRA SPTY2D1 MAP3K1 ARF1	6.60e-06	1371	64	12	36244648
Pubmed	Components of the human SWI/SNF complex are enriched in active chromatin and are associated with the nuclear matrix.	LMNB1 SMARCA2 SMARCA4	6.63e-06	20	64	3	9128241
Pubmed	TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.	SLC38A2 PAXBP1 LMNB1 VWA8 ATAD3A NUDT21 YLPM1 PSMC5 COLGALT1 CSTF2T	6.77e-06	922	64	10	27609421
Pubmed	SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.	MFAP1 PAXBP1 NUDT21 SMARCA4 SPTY2D1 NCOA5	7.03e-06	251	64	6	31076518
Pubmed	DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.	SMARCA2 SMARCA4	9.99e-06	3	64	2	30287812
Pubmed	BRCA1 interacts with dominant negative SWI/SNF enzymes without affecting homologous recombination or radiation-induced gene activation of p21 or Mdm2.	SMARCA2 SMARCA4	9.99e-06	3	64	2	15034933
Pubmed	Sck interacts with KDR and Flt-1 via its SH2 domain.	FLT1 SHC2	9.99e-06	3	64	2	9790910
Pubmed	A putative nuclear receptor coactivator (TMF/ARA160) associates with hbrm/hSNF2 alpha and BRG-1/hSNF2 beta and localizes in the Golgi apparatus.	SMARCA2 SMARCA4	9.99e-06	3	64	2	12044884
Pubmed	SWI/SNF complexes containing Brahma or Brahma-related gene 1 play distinct roles in smooth muscle development.	SMARCA2 SMARCA4	9.99e-06	3	64	2	21518954
Pubmed	ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.	ARF1 ARF3	9.99e-06	3	64	2	23783033
Pubmed	Characterization of mammary tumors from Brg1 heterozygous mice.	SMARCA2 SMARCA4	9.99e-06	3	64	2	17637742
Pubmed	Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases.	FLT1 ARF1	9.99e-06	3	64	2	22962618
Pubmed	Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models.	SMARCA2 SMARCA4	9.99e-06	3	64	2	28292935
Pubmed	Clinicopathological and prognostic significance of SWI/SNF complex subunits in undifferentiated gastric carcinoma.	SMARCA2 SMARCA4	9.99e-06	3	64	2	36464671
Pubmed	Downregulations of CD36 and Calpain-1, Inflammation, and Atherosclerosis by Simvastatin in Apolipoprotein E Knockout Mice.	CAPN1 APOE	9.99e-06	3	64	2	28448973
Pubmed	Age-related decline in the expression of BRG1, ATM and ATR are partially reversed by dietary restriction in the livers of female mice.	ATR SMARCA4	9.99e-06	3	64	2	38970714
Pubmed	Class I Arfs (Arf1 and Arf3) and Arf6 are localized to the Flemming body and play important roles in cytokinesis.	ARF1 ARF3	9.99e-06	3	64	2	26330566
Pubmed	The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes.	SMARCA2 SMARCA4	9.99e-06	3	64	2	17938176
Pubmed	Functional redundancy of SWI/SNF catalytic subunits in maintaining vascular endothelial cells in the adult heart.	SMARCA2 SMARCA4	9.99e-06	3	64	2	22740088
Pubmed	TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival.	SMARCA2 SMARCA4	9.99e-06	3	64	2	15075294
Pubmed	Heterogeneous SWI/SNF chromatin remodeling complexes promote expression of microphthalmia-associated transcription factor target genes in melanoma.	SMARCA2 SMARCA4	9.99e-06	3	64	2	19784067
Pubmed	Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation factors.	ARF1 ARF3	9.99e-06	3	64	2	10623590
Pubmed	BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progression.	SMARCA2 SMARCA4	9.99e-06	3	64	2	20571081
Pubmed	Conserved SNH domain of the proto-oncoprotein SYT interacts with components of the human chromatin remodelling complexes, while the QPGY repeat domain forms homo-oligomers.	SMARCA2 SMARCA4	9.99e-06	3	64	2	14603256
Pubmed	SWI/SNF chromatin remodeling subunit Smarca4/BRG1 is essential for female fertility†.	SMARCA2 SMARCA4	9.99e-06	3	64	2	36440965
Pubmed	Ligand-dependent interaction between the estrogen receptor and the human homologues of SWI2/SNF2.	SMARCA2 SMARCA4	9.99e-06	3	64	2	9099865
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	PAXBP1 NUDT21 YLPM1 SMARCA2 SMARCA4 PPWD1	1.02e-05	268	64	6	33640491
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	PAXBP1 ATR ATAD3A YLPM1 SMARCA2 SRPRA SPTY2D1	1.05e-05	410	64	7	26949251
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FADS1 LMNB1 NUDT21 YLPM1 SMARCA4 PSMC5 SRPRA SPTY2D1 ARF3 NCOA5	1.24e-05	989	64	10	36424410
Pubmed	A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.	NLN LMNB1 ATAD3A NUDT21 EIF2B2 PSMC5 COLGALT1 ARF1 NCOA5	1.33e-05	786	64	9	29128334
Pubmed	CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.	MFAP1 PAXBP1 LMNB1 ATAD3A YLPM1 SMARCA2 SMARCA4 NCOA5	1.50e-05	605	64	8	28977666
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	MFAP1 PHLDB1 LMNB1 ATAD3A NUDT21 YLPM1 SMARCA4 PSMC5 ARF1 NCOA5	1.68e-05	1024	64	10	24711643
Pubmed	Dual role of NRSF/REST in activation and repression of the glucocorticoid response.	SMARCA2 SMARCA4	2.00e-05	4	64	2	17984088
Pubmed	ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.	FLT1 APOE	2.00e-05	4	64	2	22581286
Pubmed	SWI/SNF chromatin-remodeling enzymes Brahma-related gene 1 (BRG1) and Brahma (BRM) are dispensable in multiple models of postnatal angiogenesis but are required for vascular integrity in infant mice.	SMARCA2 SMARCA4	2.00e-05	4	64	2	25904594
Pubmed	BRM (SNF2alpha) expression is concomitant to the onset of vasculogenesis in early mouse postimplantation development.	SMARCA2 SMARCA4	2.00e-05	4	64	2	11231080
Pubmed	BRG1/BRM and prohibitin are required for growth suppression by estrogen antagonists.	SMARCA2 SMARCA4	2.00e-05	4	64	2	15141164
Pubmed	Neuregulin-1 modulates the differentiation of neural stem cells in vitro through an interaction with the Swi/Snf complex.	SMARCA2 SMARCA4	2.00e-05	4	64	2	19781646
Pubmed	Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1.	FLT1 LMNB1	2.00e-05	4	64	2	17550303
Pubmed	Brahma safeguards canalization of cardiac mesoderm differentiation.	SMARCA2 SMARCA4	2.00e-05	4	64	2	35082446
Pubmed	Nicotinic acetylcholine receptor α1 promotes calpain-1 activation and macrophage inflammation in hypercholesterolemic nephropathy.	CAPN1 APOE	2.00e-05	4	64	2	20661225
Pubmed	Regulation of ATM and ATR by SMARCAL1 and BRG1.	ATR SMARCA4	2.00e-05	4	64	2	30317028
Pubmed	BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.	SMARCA2 SMARCA4	2.00e-05	4	64	2	28232072
Interaction	HIF1A interactions	NLN MYH6 VWA8 ATAD3A CAPN1 SMARCA2 SMARCA4 MARCHF7 ARF3	8.81e-06	441	63	9	int:HIF1A
Interaction	CIITA interactions	ATAD3A SMARCA2 SMARCA4 PSMC5	2.62e-05	55	63	4	int:CIITA
Interaction	DCPS interactions	MFAP1 LMNB1 ATAD3A CEP250 SMARCA2 INTS3 CSTF2T NCOA5	3.01e-05	394	63	8	int:DCPS
Interaction	TNIP2 interactions	SLC38A2 PAXBP1 LMNB1 VWA8 ATAD3A NUDT21 CAPN1 YLPM1 PSMC5 COLGALT1 MEAK7 CSTF2T	3.31e-05	952	63	12	int:TNIP2
Interaction	IFI27L1 interactions	MFAP1 PAXBP1 KIF1C NCOA5	5.09e-05	65	63	4	int:IFI27L1
Cytoband	5q12.3	NLN PPWD1	2.89e-04	18	64	2	5q12.3
Cytoband	6p21.2	CMTR1 DAAM2	1.17e-03	36	64	2	6p21.2
Cytoband	Xq22.1	BEX1 BEX5	1.66e-03	43	64	2	Xq22.1
GeneFamily	Brain expressed X-linked family	BEX1 BEX5	4.75e-05	5	40	2	1217
GeneFamily	AAA ATPases	ATAD3A PSMC5 KATNA1	2.18e-04	53	40	3	413
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	ARF1 ARF3	2.13e-03	31	40	2	357
Coexpression	HENDRICKS_SMARCA4_TARGETS_UP	PHLDB1 SMARCA2 SMARCA4 HKDC1	9.33e-06	54	64	4	M15057
Coexpression	GSE3982_DC_VS_MAC_LPS_STIM_UP	ZNF16 MFAP1 YLPM1 SMARCA4 INTS3 MAPK8IP3	9.50e-06	200	64	6	M5387
Disease	sodium-coupled monocarboxylate transporter 1 measurement	FADS1 SMARCA4 APOE	7.57e-06	19	60	3	EFO_0802076
Disease	free cholesterol in very large HDL measurement	FADS1 SMARCA4 APOE NCOA5	7.89e-06	62	60	4	EFO_0022273
Disease	level of Sterol ester (27:1/18:2) in blood serum	FADS1 SMARCA4 APOE	2.01e-05	26	60	3	OBA_2045194
Disease	level of Sterol ester (27:1/16:0) in blood serum	FADS1 SMARCA4 APOE	2.01e-05	26	60	3	OBA_2045191
Disease	palmitoyl sphingomyelin (d18:1/16:0) measurement	SMARCA4 APOE	2.43e-05	4	60	2	EFO_0800300
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 12	SMARCA2 SMARCA4	4.05e-05	5	60	2	C3281201
Disease	cholesteryl ester 24:6 measurement	ZNF16 APOE	6.07e-05	6	60	2	EFO_0021449
Disease	1-(1-enyl-stearoyl)-2-linoleoyl-GPE (P-18:0/18:2)* measurement	FADS1 APOE	6.07e-05	6	60	2	EFO_0020014
Disease	aspirin use measurement	FLT1 SMARCA4 APOE	6.93e-05	39	60	3	EFO_0007013
Disease	X-24870 measurement	FADS1 APOE	8.48e-05	7	60	2	EFO_0022143
Disease	level of Sterol ester (27:1/22:6) in blood serum	FADS1 APOE	8.48e-05	7	60	2	OBA_2045201
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	SMARCA4 APOE	1.13e-04	8	60	2	EFO_0008589, EFO_0008595
Disease	angina pectoris	FLT1 SMARCA4 RNF213 APOE	1.25e-04	125	60	4	EFO_0003913
Disease	myopathy (implicated_via_orthology)	MYH6 LMNB1 PSMC5	1.30e-04	48	60	3	DOID:423 (implicated_via_orthology)
Disease	cholesteryl ester 20:3 measurement	FADS1 BMERB1 APOE	1.38e-04	49	60	3	EFO_0010347
Disease	opportunistic bacterial infectious disease (implicated_via_orthology)	SMARCA2 SMARCA4	1.45e-04	9	60	2	DOID:0050340 (implicated_via_orthology)
Disease	oleoyl-arachidonoyl-glycerol (18:1/20:4) [1] measurement	FADS1 APOE	1.81e-04	10	60	2	EFO_0800507
Disease	linoleoyl-arachidonoyl-glycerol (18:2/20:4) [1] measurement	FADS1 APOE	1.81e-04	10	60	2	EFO_0800499
Disease	1-stearoyl-2-linoleoyl-GPE (18:0/18:2) measurement	FADS1 APOE	1.81e-04	10	60	2	EFO_0800402
Disease	Antithrombotic agent use measurement	FLT1 SMARCA4 APOE	1.94e-04	55	60	3	EFO_0009925
Disease	free cholesterol to total lipids in large HDL percentage	FADS1 SMARCA4 NCOA5	2.05e-04	56	60	3	EFO_0022279
Disease	cancer (implicated_via_orthology)	FLT1 SMARCA2 SMARCA4 PSMC5 ACAP2	2.16e-04	268	60	5	DOID:162 (implicated_via_orthology)
Disease	placenta growth factor measurement	FLT1 EIF2B2	2.21e-04	11	60	2	EFO_0010626
Disease	linoleoyl-arachidonoyl-glycerol (18:2/20:4) [2] measurement	FADS1 APOE	2.65e-04	12	60	2	EFO_0800500
Disease	level of Phosphatidylcholine (O-16:0_20:3) in blood serum	FADS1 APOE	2.65e-04	12	60	2	OBA_2045115
Disease	Coffin-Siris syndrome	SMARCA2 SMARCA4	3.13e-04	13	60	2	C0265338
Disease	level of Sphingomyelin (d34:2) in blood serum	FADS1 SMARCA4	3.13e-04	13	60	2	OBA_2045174
Disease	total lipids in very large HDL measurement	FADS1 APOE NCOA5	3.34e-04	66	60	3	EFO_0022312
Disease	phospholipids in very large HDL measurement	FADS1 APOE NCOA5	3.34e-04	66	60	3	EFO_0022298
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	SMARCA4 APOE	3.64e-04	14	60	2	EFO_0004611, EFO_0008589
Disease	fatty acid measurement, linoleic acid measurement	FADS1 SMARCA4 APOE	3.65e-04	68	60	3	EFO_0005110, EFO_0006807
Disease	cholesterol in very large HDL measurement	FADS1 APOE NCOA5	3.81e-04	69	60	3	EFO_0022229
Disease	oleoyl-arachidonoyl-glycerol (18:1/20:4) [2] measurement	FADS1 APOE	4.20e-04	15	60	2	EFO_0800508
Disease	level of Phosphatidylcholine (16:0_16:0) in blood serum	FADS1 SMARCA4	4.20e-04	15	60	2	OBA_2045067
Disease	level of Sterol ester (27:1/18:1) in blood serum	SMARCA4 APOE	4.79e-04	16	60	2	OBA_2045195
Disease	level of Phosphatidylcholine (18:0_20:3) in blood serum	FADS1 BMERB1	4.79e-04	16	60	2	OBA_2045093
Disease	S-adenosylhomocysteine measurement	VWA8 KATNA1	5.42e-04	17	60	2	EFO_0010531
Disease	Kuhnt-Junius degeneration (is_implicated_in)	FLT1 APOE	5.42e-04	17	60	2	DOID:10873 (is_implicated_in)
Disease	free cholesterol in large HDL measurement	FADS1 APOE NCOA5	5.66e-04	79	60	3	EFO_0022157
Disease	hypothyroidism (biomarker_via_orthology)	MYH6 ALAD APOE	5.87e-04	80	60	3	DOID:1459 (biomarker_via_orthology)
Disease	triacylglycerol 56:3 measurement	FADS1 APOE	6.09e-04	18	60	2	EFO_0010430
Disease	level of Sphingomyelin (d34:1) in blood serum	SMARCA4 APOE	6.09e-04	18	60	2	OBA_2045175
Disease	diacylglycerol 36:3 measurement	FADS1 APOE	6.09e-04	18	60	2	EFO_0020062
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	SMARCA4 APOE	6.09e-04	18	60	2	EFO_0008317, EFO_0008589
Disease	diacylglycerol 38:5 measurement	FADS1 APOE	6.80e-04	19	60	2	EFO_0020067
Disease	omega-6 polyunsaturated fatty acid measurement	FADS1 SMARCA4 BMERB1 APOE	7.02e-04	197	60	4	EFO_0005680
Disease	free cholesterol:total lipids ratio, intermediate density lipoprotein measurement	FADS1 SMARCA4 APOE	7.25e-04	86	60	3	EFO_0008595, EFO_0020945
Disease	Adenocarcinoma of lung (disorder)	FLT1 LMNB1 ATR NUDT21	8.29e-04	206	60	4	C0152013
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	SMARCA4 APOE	8.33e-04	21	60	2	EFO_0022246
Disease	sleep duration, low density lipoprotein cholesterol measurement	FADS1 SMARCA4 APOE	8.55e-04	91	60	3	EFO_0004611, EFO_0005271
Disease	metabolite measurement	SLC38A2 FADS1 YLPM1 L3HYPDH APOE NCOA5	9.56e-04	560	60	6	EFO_0004725
Disease	clinical and behavioural ideal cardiovascular health	SMARCA4 APOE	1.00e-03	23	60	2	EFO_0007654
Disease	low density lipoprotein cholesterol measurement, alcohol consumption measurement	FADS1 SMARCA4 SPTY2D1	1.09e-03	99	60	3	EFO_0004611, EFO_0007878
Disease	breast cancer (implicated_via_orthology)	ATR SMARCA4	1.18e-03	25	60	2	DOID:1612 (implicated_via_orthology)
Disease	phospholipids:total lipids ratio	FADS1 SMARCA4 APOE NCOA5	1.19e-03	227	60	4	EFO_0020946
Disease	low density lipoprotein cholesterol measurement, alcohol drinking	FADS1 SMARCA4 SPTY2D1	1.19e-03	102	60	3	EFO_0004329, EFO_0004611
Disease	cholesterol to total lipids in small LDL percentage	SMARCA4 APOE	1.38e-03	27	60	2	EFO_0022241
Disease	cholesterol to total lipids in medium LDL percentage	SMARCA4 APOE	1.38e-03	27	60	2	EFO_0022238
Disease	neuroimaging measurement	FADS1 SMARCA2 APOE PPWD1 MEAK7 MAP3K1 ARF1 MAPK8IP3	1.39e-03	1069	60	8	EFO_0004346
Disease	coronary artery disease, factor VII measurement	FLT1 SMARCA4 APOE	1.52e-03	111	60	3	EFO_0001645, EFO_0004619
Disease	Neoplasm of uncertain or unknown behavior of ovary	ATR SMARCA4	1.59e-03	29	60	2	C0496920
Disease	level of Sphingomyelin (d42:2) in blood serum	SMARCA4 APOE	1.59e-03	29	60	2	OBA_2045183
Disease	factor VIII measurement, coronary artery disease	FLT1 SMARCA4 APOE	1.60e-03	113	60	3	EFO_0001645, EFO_0004630
Disease	factor XI measurement, coronary artery disease	FLT1 SMARCA4 APOE	1.68e-03	115	60	3	EFO_0001645, EFO_0004694
Disease	antihyperlipidemic drug use measurement	FADS1 SMARCA4 APOE	1.68e-03	115	60	3	EFO_0803367
Disease	Ovarian Carcinoma	ATR SMARCA4	1.71e-03	30	60	2	C0029925
Disease	omega-3 polyunsaturated fatty acid measurement	FADS1 SMARCA4 APOE	1.81e-03	118	60	3	EFO_0010119
Disease	von Willebrand factor measurement, coronary artery disease	FLT1 SMARCA4 APOE	1.81e-03	118	60	3	EFO_0001645, EFO_0004629
Disease	level of Sterol ester (27:1/20:4) in blood serum	FADS1 APOE	1.82e-03	31	60	2	OBA_2045198
Disease	cholesteryl ester measurement	FADS1 SMARCA4 APOE NCOA5	1.87e-03	257	60	4	EFO_0010351
Disease	level of Sphingomyelin (d40:1) in blood serum	SMARCA4 APOE	1.94e-03	32	60	2	OBA_2045182

Protein segments in the cluster

Peptide	Gene	Start	Entry
EGARMVRELFVMARE	PSMC5	226	P62195
RLRARMEEMGSRTRD	APOE	231	P02649
MEEMGSRTRDRLDEV	APOE	236	P02649
RMREENMERIGEEVR	BEX1	76	Q9HBH7
AMRRATVEREMELRH	ATAD3A	216	Q9NVI7
DRERVNEAREELMRM	ARF3	96	P61204
LRLARMNEEMRESEG	ACAP2	726	Q15057
MSFRDFMREFTRLEI	CAPN1	336	P07384
LRERFMECLMIGRDL	INTS3	241	Q68E01
RKEEEERRARMEAML	DAAM2	981	Q86T65
DDEEIERRRGMMRQR	MFAP1	141	P55081
LRTRLAEMDRDLMVG	LZIC	106	Q8WZA0
RRFTRVEMARVLMER	MAPK8IP3	521	Q9UPT6
REEEERLEAMMRRSL	MAP7D2	121	Q96T17
RAVDRDVREGADMLM	ALAD	236	P13716
VLVRRESELRFMMDD	BMERB1	66	Q96MC5
FLQILRMVRMDRRGG	KCNQ5	236	Q9NR82
RRMLTDKEREMAEIR	LMNB1	336	P20700
FMEEMRELRRKIREL	BEX5	71	Q5H9J7
RGMEEFMERESLLRR	BMP15	251	O95972
RDMRDSRDPMYRREG	NCOA5	111	Q9HCD5
RRMEEFTEFAELERM	DNAH12	621	Q6ZR08
RELQALRDRMLRMER	KIF1C	856	O43896
EMVTRLYDGMRRVDL	MEAK7	61	Q6P9B6
LLLRMRRTLDDDVFM	PAXBP1	736	Q9Y5B6
MDSLREARREDMLRL	NSUN6	436	Q8TEA1
RPMRAEDMLREIREE	PLEKHG6	731	Q3KR16
LFRRACEVTMRLMRD	ATR	2531	Q13535
LAVRERERLQEMLMG	CEP250	516	Q9BV73
DRERVNEAREELMRM	ARF1	96	P84077
EFRELRATVERMGLM	FADS1	111	O60427
GTDLMRERRDLERRT	MARCHF7	136	Q9H992
RDASLMAMRRRIEGL	KATNA1	426	O75449
EVLETRVMERRGMET	CSTF2T	426	Q9H0L4
RMREEFDKIGMRRTV	NUDT21	66	O43809
ELMELIRREGRRMTA	EIF2B2	56	P49770
RRLMNLMRDVEREGL	COLGALT1	446	Q8NBJ5
FDVLDGEEMRRARTR	CMTR1	206	Q8N1G2
RMRRRLMAIADEVEI	MAP3K1	851	Q13233
MRAVLAREMDGRRVL	RPUSD3	1	Q6P087
ERIEKERMRRLMAED	SMARCA2	496	P51531
ERMRRLMAEDEEGYR	SMARCA2	501	P51531
RMLGADREFIEARRR	SNX8	136	Q9Y5X2
LMEEMARADRETRLF	TMEM191B	256	P0C7N4
LLDIMRRFRAEMEKG	HKDC1	36	Q2TB90
GRLRATFMREIRRDE	IQCA1L	176	A6NCM1
PDMEFGRRMAVEREL	PPWD1	336	Q96BP3
AVLRDMRMLEEAARL	PYDC1	71	Q8WXC3
RIEKERMRRLMAEDE	SMARCA4	521	P51532
RMRRLMAEDEEGYRK	SMARCA4	526	P51532
EEFDLFMRMDLDRRR	SMARCA4	1311	P51532
FMRMDLDRRREEARN	SMARCA4	1316	P51532
EEMRDERLSRIITRM	MYH6	776	P13533
LRLGMQEDLEEMRRE	SPTY2D1	656	Q68D10
VRRRLMFEPRGHRDM	L3HYPDH	61	Q96EM0
GRMIAEEIMEIHRIR	ARNTL	496	O00327
EMRQDLGIRADRARM	APOBR	471	Q0VD83
RFDIEMSMRGDIFER	NLN	131	Q9BYT8
EAARYRMRRVMEELP	RNF213	1751	Q63HN8
MDRNREAEMELRRGP	ZNF516	1	Q92618
RMSRRAAERMLRADG	SHC2	491	P98077
PIYEELKDRSRRRMM	SLC38A2	311	Q96QD8
RRVDMLRDIMDAQRR	SRPRA	401	P08240
MESREREMELRRQAL	PHLDB1	1166	Q86UU1
EMERDMDRDVDRISR	YLPM1	1281	P49750
MPSLRTRREEAEMEL	ZNF16	1	P17020
YRFNRMDGRLERTME	VWA8	1726	A3KMH1
DEDFCSRLREGMRMR	FLT1	1106	P17948
MELMRGGELLDRILR	RPS6KA2	486	Q15349
RVTEERRRMMERGFL	MYO9A	126	B2RTY4