Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cell junction assembly	DOCK1 LRRN1 CNTN5 PCDHB11 EPB41L3 DCX SDK1 POF1B CLDN8	1.78e-05	569	55	9	GO:0034329
GeneOntologyBiologicalProcess	cell junction organization	DOCK1 SEMA3A IQSEC3 LRRN1 CNTN5 PCDHB11 EPB41L3 DCX SDK1 POF1B CLDN8	4.36e-05	974	55	11	GO:0034330
Domain	Dullard_phosphatase	CTDSP1 CTDSPL	8.47e-05	5	55	2	IPR011948
Domain	CPDc	CTDSP1 CTDSPL	2.36e-04	8	55	2	SM00577
Domain	FCP1	CTDSP1 CTDSPL	2.36e-04	8	55	2	PS50969
Domain	FCP1_dom	CTDSP1 CTDSPL	3.02e-04	9	55	2	IPR004274
Domain	NIF	CTDSP1 CTDSPL	3.02e-04	9	55	2	PF03031
Domain	ARM-type_fold	DOCK1 TNPO1 RALGAPA1 DNAJC13 PSME4 VEPH1	4.69e-04	339	55	6	IPR016024
Domain	IG	SEMA3A LRIT2 LRRN1 CNTN5 MPIG6B SDK1	1.44e-03	421	55	6	SM00409
Domain	Ig_sub	SEMA3A LRIT2 LRRN1 CNTN5 MPIG6B SDK1	1.44e-03	421	55	6	IPR003599
Domain	FN3	LRIT2 LRRN1 CNTN5 SDK1	2.14e-03	185	55	4	SM00060
Domain	Ig_I-set	LRIT2 LRRN1 CNTN5 SDK1	2.36e-03	190	55	4	IPR013098
Domain	I-set	LRIT2 LRRN1 CNTN5 SDK1	2.36e-03	190	55	4	PF07679
Domain	FN3	LRIT2 LRRN1 CNTN5 SDK1	2.79e-03	199	55	4	PS50853
Domain	FN3_dom	LRIT2 LRRN1 CNTN5 SDK1	3.33e-03	209	55	4	IPR003961
Pubmed	Variability in the common genetic architecture of social-communication spectrum phenotypes during childhood and adolescence.	DOCK1 SCN11A EPB41L3	3.76e-06	19	56	3	24564958
Pubmed	Tumor suppressor properties of the small C-terminal domain phosphatases in non-small cell lung cancer.	CTDSP1 CTDSPL	7.63e-06	3	56	2	31774910
Pubmed	Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.	CTDSP1 CTDSPL	7.63e-06	3	56	2	17085434
Pubmed	Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan.	DOCK1 FOXRED1 PSME4 MAP1S ST14	1.17e-05	183	56	5	31932471
Pubmed	Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.	CTDSP1 CTDSPL	1.52e-05	4	56	2	16882717
Pubmed	Small C-terminal domain phosphatase enhances snail activity through dephosphorylation.	CTDSP1 CTDSPL	1.52e-05	4	56	2	19004823
Pubmed	Cell corpse engulfment mediated by C. elegans phosphatidylserine receptor through CED-5 and CED-12.	DOCK1 CTDSPL	1.52e-05	4	56	2	14645848
Pubmed	Cell cycle promoting activity of JunB through cyclin A activation.	JUNB CCNA1	2.54e-05	5	56	2	12121977
Pubmed	Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein.	CTDSP1 CTDSPL	2.54e-05	5	56	2	32973332
Pubmed	TonEBP Regulates PCNA Polyubiquitination in Response to DNA Damage through Interaction with SHPRH and USP1.	NFAT5 USP1	2.54e-05	5	56	2	31376680
Pubmed	MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein.	CTDSP1 CTDSPL	3.80e-05	6	56	2	22210897
Pubmed	An Optimized Preparation Method for Long ssDNA Donors to Facilitate Quick Knock-In Mouse Generation.	PCDHB11 DCX	9.10e-05	9	56	2	33946570
Pubmed	A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5.	CTDSP1 CTDSPL	1.14e-04	10	56	2	12721286
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	TNPO1 TBCCD1 DNAJC16 BAG3 RBM26 KANK2 POF1B PPL	1.59e-04	974	56	8	28675297
Pubmed	A protein domain-based interactome network for C. elegans early embryogenesis.	JUNB CCNA1	1.96e-04	13	56	2	18692475
Pubmed	Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.	RBBP5 DNAJC16 RBM26	2.09e-04	71	56	3	36305789
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	TNPO1 DNAJC13 MAP1S COG1 DNAJC16 CDC7	4.23e-04	606	56	6	36538041
Pubmed	Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.	SEMA3A DCX	4.75e-04	20	56	2	30819894
Pubmed	Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library.	EPB41L3 NFAT5	5.24e-04	21	56	2	8401585
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	DOCK1 RALGAPA1 DNAJC13 LRRN1 TTLL11 WDR27 PHF14 NFAT5 CTDSPL	5.81e-04	1489	56	9	28611215
Pubmed	Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation.	CCNA1 DCX	8.71e-04	27	56	2	28768199
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	SEMA3A LRRN1 SDK1	9.03e-04	117	56	3	17145500
Pubmed	Self-assembling protein microarrays.	CCNA1 CDC7	1.08e-03	30	56	2	15232106
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	RALGAPA1 GLB1 DNAJC16 RBM26 USP1 KANK2	1.14e-03	733	56	6	34672954
Pubmed	STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.	JUNB BAG3	1.15e-03	31	56	2	28089446
Pubmed	High-throughput analyses of hnRNP H1 dissects its multi-functional aspect.	TNPO1 FOXRED1 PSME4 SLC39A1 LRRC56 WDR27 CTDSP1	1.22e-03	1021	56	7	26760575
Pubmed	Maternal diabetes alters transcriptional programs in the developing embryo.	SEMA3A DCX	1.22e-03	32	56	2	19538749
Pubmed	Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum.	SEMA3A DCX	1.30e-03	33	56	2	18199763
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRIT2 LRRN1	1.38e-03	34	56	2	18848646
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RALGAPA1 CNNM1 DNAJC13 BAG3 CTDSP1 USP1 CTDSPL	1.42e-03	1049	56	7	27880917
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	JUNB DNAJC13 MAP1S BAG3 PHF14 PPL	1.50e-03	774	56	6	15302935
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	SCN11A GLB1 CTDSPL	1.50e-03	184	56	3	chr3p22
GeneFamily	CTD family phosphatases	CTDSP1 CTDSPL	1.19e-04	8	38	2	1041
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRIT2 LRRN1 CNTN5 SDK1	3.53e-04	161	38	4	593
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	DNAJC13 DNAJC16	4.75e-03	49	38	2	584
GeneFamily	Immunoglobulin like domain containing	SEMA3A CNTN5 SDK1	7.68e-03	193	38	3	594
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#2_top-relative-expression-ranked_1000	DOCK1 SEMA3A RALGAPA1 TENT5A EPB41L3 NFAT5 KANK2 DCX	1.33e-06	312	55	8	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000_k2
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_1000	DOCK1 SEMA3A RALGAPA1 LRRN1 TENT5A PCDHB11 EPB41L3 KANK2 DCX POF1B	3.65e-05	806	55	10	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_1000	DOCK1 SEMA3A RALGAPA1 TENT5A PCDHB11 EPB41L3 NFAT5 KANK2 DCX ST14	3.65e-05	806	55	10	gudmap_developingLowerUrinaryTract_e14.5_ urethra_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#5_top-relative-expression-ranked_500	DOCK1 TENT5A EPB41L3 NFAT5 DCX	4.17e-05	149	55	5	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_top-relative-expression-ranked_100	DOCK1 POF1B ST14 CLDN8	5.24e-05	79	55	4	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_100
CoexpressionAtlas	DevelopingKidney_e15.5_Medullary collecting duct_emap-28063_top-relative-expression-ranked_200	DOCK1 NFAT5 POF1B ST14 CLDN8	5.86e-05	160	55	5	gudmap_developingKidney_e15.5_Medullary collecting duct_200
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_top-relative-expression-ranked_500	DOCK1 SEMA3A TENT5A PCDHB11 EPB41L3 NFAT5 DCX	8.29e-05	407	55	7	gudmap_developingLowerUrinaryTract_e14.5_ urethra_500
CoexpressionAtlas	e9.5_OlfacPlacod_top-relative-expression-ranked_500	SEMA3A DNAJC13 TENT5A PCDHB11 CTDSPL ST14	8.91e-05	283	55	6	Facebase_ST1_e9.5_OlfacPlacod_500
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#4_top-relative-expression-ranked_500	DOCK1 EPB41L3 NFAT5 KANK2	1.03e-04	94	55	4	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_500_k4
CoexpressionAtlas	DevelopingKidney_e14.5 whole kidney - Wnt4 KO_emap-6674_k-means-cluster#5_top-relative-expression-ranked_500	LRRN1 TENT5A DCX	1.76e-04	42	55	3	gudmap_developingKidney_e14.5 whole kidney - Wnt4 KO_500_k5
CoexpressionAtlas	DevelopingKidney_e15.5_Ureteral Smooth Musc_emap-28812_k-means-cluster#5_top-relative-expression-ranked_1000	DOCK1 RALGAPA1 EPB41L3 NFAT5 KANK2	1.79e-04	203	55	5	gudmap_developingKidney_e15.5_Ureteral Smooth Musc_1000_k5
Disease	social communication impairment	DOCK1 SCN11A EPB41L3	3.09e-05	32	56	3	EFO_0005427
Disease	quality of life during menstruation measurement, acne	TENT5A SDK1	1.92e-04	11	56	2	EFO_0003894, EFO_0009366
Disease	smoking status measurement, Cannabis use, schizophrenia	FOXO6 SDK1	1.39e-03	29	56	2	EFO_0006527, EFO_0007585, MONDO_0005090
Disease	aspartate aminotransferase measurement	TNPO1 CNNM1 DNAJC13 GLB1 RBBP5 BAG3 SRMS	1.55e-03	904	56	7	EFO_0004736

Protein segments in the cluster

Peptide	Gene	Start	Entry
SPEAGLAEYLFDKLT	FTHL17	161	Q9BXU8
AIYASAELKILASAP	CNTN5	466	O94779
DADPSALAKYVLALV	RBM26	26	Q5T8P6
LETKERLYLLAAPAA	DOK2	86	O60496
ETLVLLNPSDKSLYD	MAP1S	86	Q66K74
KSLYDELRNLLLDPA	MAP1S	96	Q66K74
DDLLPGTKYEACLSL	LRIT2	421	A6NDA9
LLRSSDPDYLAAVDK	GLB1	146	P16278
PLSEAGDLTEKYFAL	GLB1	336	P16278
LDSEKLLYVLEADAA	PPL	76	O60437
FTASLAKYADPVADL	CTDSP1	151	Q9GZU7
LSYADLITKAIESAP	FOXO6	91	A8MYZ6
YLSLAAITKADLLAD	VEPH1	151	Q14D04
YLDQLRKDPALLSSE	DNAJC16	481	Q9Y2G8
PAASDYELSLDLKNK	IQSEC3	286	Q9UPP2
ADLDLESPKSLYSRE	NFAT5	11	O94916
KLDPRYFGELLADLS	POF1B	251	Q8WVV4
KPLAASLLEALDYDS	PHF14	11	O94880
EELEDSKALLYLPIA	RBBP5	391	Q15291
LDKALDYEELPELSF	PCDHB11	196	Q9Y5F2
LDQELALPKDSYLLD	NPC1L1	871	Q9UHC9
KSPAYEALTFELLLE	NT5DC4	31	Q86YG4
LPEELSYLSSAAALA	C6orf15	131	Q6UXA7
LEDAATYLSLPSTKA	DOCK1	561	Q14185
DLLAYLPSDDSSLPK	COG1	531	Q8WTW3
EAYDLLDKLLDLNPA	CDC7	541	O00311
LFTASLAKYADPVAD	CTDSPL	166	O15194
KYVAELSLLEADPFL	CCNA1	366	P78396
HKDLYLPLSLDDSDS	DCX	346	O43602
PSGYLLLASEKDAAA	FOXRED1	156	Q96CU9
LAYLESSDLVPEKDA	DNAJC13	661	O75165
SPDLISACLALEKYL	KANK2	591	Q63ZY3
EYLTKELLALDSVDP	BAG3	456	O95817
DLAPESAYIFRLSAK	SDK1	1441	Q7Z5N4
YLEPKAASLSASLDN	EPB41L3	666	Q9Y2J2
YALDNLPELTKLEAT	LRRN1	306	Q6UXK5
AEAEKTFSYPLDLLL	TRAPPC4	26	Q9Y296
TFSYPLDLLLKLHDE	TRAPPC4	31	Q9Y296
LDGIASLPALKELYA	LRRC56	131	Q8IYG6
AAVYLLDDPLAALDA	ABCC6	771	O95255
EPSLLYADLDHLALS	MPIG6B	206	O95866
ALLESELYPALKLEA	SPATA32	71	Q96LK8
YDPKLLTASLLIDGE	SEMA3A	171	Q14563
LARLLKDDIYSPSSS	SRMS	371	Q9H3Y6
IYDSLLALSPDLQAA	CLDN8	66	P56748
KLLETLRAADPYSDL	CNNM1	396	Q9NRU3
SLDPLEIYIAKDGLS	TTLL11	396	Q8NHH1
NLYSLDLSDLPLDKL	RALGAPA1	676	Q6GYQ0
LDLLPDYLAAIDEAL	SLC39A1	86	Q9NY26
DIALLELEKPAEYSS	ST14	711	Q9Y5Y6
KLLPYAERLDAESDL	PSME4	36	Q14997
DLLPKLCSLLDSEDY	TNPO1	136	Q92973
IKYSALSDFADALPE	SCN11A	1641	Q9UI33
YDHLSDLLELLLDPK	TBCCD1	176	Q9NVR7
LSAYPLLSLFIDAES	WDR27	206	A2RRH5
KCLADDYIPISAALS	SNX32	236	Q86XE0
KLDSLLLFYECSENP	TENT5A	236	Q96IP4
ASFLLNPEKYTDELA	USP1	161	O94782
DYKLLKPSLAVNLAD	JUNB	31	P17275