Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	neural tube development	TBC1D32 FOXB1 FZD3 MTHFD1L EPHA2 TSC2 FZD2	1.94e-06	202	60	7	GO:0021915
GeneOntologyBiologicalProcess	tube development	TBC1D32 HHIP FOXB1 SPI1 FZD3 MTHFD1L EPHA2 DACT2 WT1 PDX1 TSC2 FZD2 LEPR EPHA5	3.78e-05	1402	60	14	GO:0035295
GeneOntologyBiologicalProcess	protein localization to cilium	SPATA7 TBC1D32 ENTR1 PCARE	7.47e-05	77	60	4	GO:0061512
GeneOntologyBiologicalProcess	cell morphogenesis	BOC FOXB1 SPI1 FZD3 EPHA2 FAT3 DACT2 TSC2 NLGN1 PIAS2 ZMYM4 EPHA5	1.41e-04	1194	60	12	GO:0000902
GeneOntologyBiologicalProcess	smoothened signaling pathway	BOC TBC1D32 HHIP PDX1 RFX4	1.60e-04	176	60	5	GO:0007224
GeneOntologyBiologicalProcess	protein localization to photoreceptor outer segment	SPATA7 PCARE	1.73e-04	7	60	2	GO:1903546
GeneOntologyBiologicalProcess	epithelial tube morphogenesis	HHIP FZD3 MTHFD1L EPHA2 WT1 TSC2 FZD2	2.13e-04	421	60	7	GO:0060562
GeneOntologyBiologicalProcess	morphogenesis of embryonic epithelium	FZD3 MTHFD1L PDX1 TSC2 FZD2	2.28e-04	190	60	5	GO:0016331
GeneOntologyBiologicalProcess	epithelium development	TBC1D32 HHIP FOXB1 FZD3 MTHFD1L RPTOR EPHA2 DACT2 WT1 PDX1 TSC2 FZD2 MADCAM1	2.53e-04	1469	60	13	GO:0060429
GeneOntologyBiologicalProcess	regulation of protein localization	UBE2G2 ABHD17B SPI1 RPTOR EPHA2 SLC26A4 ENTR1 PDX1 NLGN1 LEPR EPHA5	2.63e-04	1087	60	11	GO:0032880
GeneOntologyBiologicalProcess	cardiac muscle cell fate commitment	VWA5A WT1	2.96e-04	9	60	2	GO:0060923
GeneOntologyBiologicalProcess	tissue morphogenesis	HHIP FZD3 MTHFD1L EPHA2 WT1 PDX1 TSC2 ADAMTS5 FZD2	2.97e-04	750	60	9	GO:0048729
GeneOntologyBiologicalProcess	neural tube closure	FZD3 MTHFD1L TSC2 FZD2	3.29e-04	113	60	4	GO:0001843
GeneOntologyBiologicalProcess	tube closure	FZD3 MTHFD1L TSC2 FZD2	3.40e-04	114	60	4	GO:0060606
GeneOntologyBiologicalProcess	pericyte cell differentiation	SPI1 EPHA2	3.69e-04	10	60	2	GO:1904238
GeneOntologyBiologicalProcess	morphogenesis of an epithelium	HHIP FZD3 MTHFD1L EPHA2 WT1 PDX1 TSC2 FZD2	4.07e-04	619	60	8	GO:0002009
GeneOntologyBiologicalProcess	primary neural tube formation	FZD3 MTHFD1L TSC2 FZD2	4.13e-04	120	60	4	GO:0014020
Domain	SAM_1	EPHA2 SCML1 CNKSR2 EPHA5	7.65e-05	68	62	4	PF00536
Domain	SAM	EPHA2 SCML1 CNKSR2 EPHA5	2.08e-04	88	62	4	SM00454
Domain	SAM_DOMAIN	EPHA2 SCML1 CNKSR2 EPHA5	2.80e-04	95	62	4	PS50105
Domain	SAM	EPHA2 SCML1 CNKSR2 EPHA5	3.03e-04	97	62	4	IPR001660
Domain	FN3	BOC EPHA2 IL21R LEPR EPHA5	3.70e-04	185	62	5	SM00060
Domain	Hempt_rcpt_S_F1_CS	IL21R LEPR	3.85e-04	9	62	2	IPR003531
Domain	-	EPHA2 SCML1 CNKSR2 EPHA5	4.25e-04	106	62	4	1.10.150.50
Domain	FN3	BOC EPHA2 IL21R LEPR EPHA5	5.16e-04	199	62	5	PS50853
Domain	Frizzled	FZD3 FZD2	5.85e-04	11	62	2	IPR000539
Domain	Frizzled	FZD3 FZD2	5.85e-04	11	62	2	PF01534
Domain	Frizzled	FZD3 FZD2	5.85e-04	11	62	2	SM01330
Domain	SAM/pointed	EPHA2 SCML1 CNKSR2 EPHA5	6.17e-04	117	62	4	IPR013761
Domain	FN3_dom	BOC EPHA2 IL21R LEPR EPHA5	6.45e-04	209	62	5	IPR003961
Domain	RECEPTOR_TYR_KIN_V_2	EPHA2 EPHA5	9.62e-04	14	62	2	PS00791
Domain	RECEPTOR_TYR_KIN_V_1	EPHA2 EPHA5	9.62e-04	14	62	2	PS00790
Domain	Eph_TM	EPHA2 EPHA5	9.62e-04	14	62	2	IPR027936
Domain	Tyr_kinase_rcpt_V_CS	EPHA2 EPHA5	9.62e-04	14	62	2	IPR001426
Domain	EPH_lbd	EPHA2 EPHA5	9.62e-04	14	62	2	SM00615
Domain	Ephrin_lbd	EPHA2 EPHA5	9.62e-04	14	62	2	PF01404
Domain	EphA2_TM	EPHA2 EPHA5	9.62e-04	14	62	2	PF14575
Domain	Tyr_kinase_ephrin_rcpt	EPHA2 EPHA5	9.62e-04	14	62	2	IPR016257
Domain	Ephrin_rcpt_lig-bd_dom	EPHA2 EPHA5	9.62e-04	14	62	2	IPR001090
Domain	EPH_LBD	EPHA2 EPHA5	9.62e-04	14	62	2	PS51550
Domain	Frizzled/SFRP	FZD3 FZD2	1.26e-03	16	62	2	IPR015526
Domain	FRI	FZD3 FZD2	1.98e-03	20	62	2	SM00063
Domain	-	FZD3 FZD2	2.19e-03	21	62	2	1.10.2000.10
Domain	Frizzled_dom	FZD3 FZD2	2.85e-03	24	62	2	IPR020067
Domain	FZ	FZD3 FZD2	2.85e-03	24	62	2	PS50038
Domain	Fz	FZD3 FZD2	2.85e-03	24	62	2	PF01392
Domain	Ephrin_rec_like	EPHA2 EPHA5	3.10e-03	25	62	2	SM01411
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHA2 EPHA5	3.10e-03	25	62	2	IPR011641
Pubmed	Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved glycemic control and reduced blood pressure.	CACNA1B LEPR	3.23e-06	2	63	2	27273361
Pubmed	Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.	EPHA2 SLC26A4	3.23e-06	2	63	2	32165640
Pubmed	DNA demethylation of promoter region orchestrates SPI-1-induced ADAMTS-5 expression in articular cartilage of osteoarthritis mice.	SPI1 ADAMTS5	3.23e-06	2	63	2	38149721
Pubmed	Reversal of memory and autism-related phenotypes in Tsc2+/- mice via inhibition of Nlgn1.	TSC2 NLGN1	3.23e-06	2	63	2	37293130
Pubmed	Expression of two novel eph-related receptor protein tyrosine kinases in mammary gland development and carcinogenesis.	EPHA2 EPHA5	9.68e-06	3	63	2	8152808
Pubmed	Association of PI3K/AKT/mTOR pathway autophagy-related gene polymorphisms with pulmonary tuberculosis susceptibility in a Chinese population.	RPTOR TSC2	9.68e-06	3	63	2	37493735
Pubmed	Reduced juvenile long-term depression in tuberous sclerosis complex is mitigated in adults by compensatory recruitment of mGluR5 and Erk signaling.	RPTOR TSC2	9.68e-06	3	63	2	23966835
Pubmed	Prognostic significance of the methylation of Wnt pathway antagonists-CXXC4, DACT2, and the inhibitors of sonic hedgehog signaling-ZIC1, ZIC4, and HHIP in head and neck squamous cell carcinomas.	HHIP DACT2	9.68e-06	3	63	2	27553089
Pubmed	HDAC5 promotes optic nerve regeneration by activating the mTOR pathway.	RPTOR TSC2	9.68e-06	3	63	2	30910408
Pubmed	The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.	RPTOR TSC2	9.68e-06	3	63	2	20616807
Pubmed	Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival.	EPHA2 EPHA5	9.68e-06	3	63	2	16737551
Pubmed	Leptin Signaling Suppression in Macrophages Improves Immunometabolic Outcomes in Obesity.	RPTOR LEPR	9.68e-06	3	63	2	35377454
Pubmed	mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.	RPTOR LEPR	9.68e-06	3	63	2	21606597
Pubmed	A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.	SPI1 FZD3 FZD2	1.12e-05	24	63	3	9096311
Pubmed	Enhanced plasticity of retinothalamic projections in an ephrin-A2/A5 double mutant.	EPHA2 EPHA5	1.93e-05	4	63	2	11567058
Pubmed	Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses.	RPTOR LEPR	1.93e-05	4	63	2	37863051
Pubmed	DOCK5 regulates energy balance and hepatic insulin sensitivity by targeting mTORC1 signaling.	RPTOR LEPR	1.93e-05	4	63	2	31885214
Pubmed	Hedgehog Interacting Protein Promotes Fibrosis and Apoptosis in Glomerular Endothelial Cells in Murine Diabetes.	HHIP LEPR	1.93e-05	4	63	2	29654303
Pubmed	Ephrin-A2 and ephrin-A5 guide contralateral targeting but not topographic mapping of ventral cochlear nucleus axons.	EPHA2 EPHA5	1.93e-05	4	63	2	26666565
Pubmed	AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation.	RPTOR TSC2	3.22e-05	5	63	2	32912901
Pubmed	Clinical significance of ephrin (eph)-A1, -A2, -a4, -a5 and -a7 receptors in pancreatic ductal adenocarcinoma.	EPHA2 EPHA5	3.22e-05	5	63	2	19949912
Pubmed	Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.	RPTOR TSC2	3.22e-05	5	63	2	23142078
Pubmed	A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis.	PIEZO1 LEPR	3.22e-05	5	63	2	33627868
Pubmed	mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC).	RPTOR LEPR	3.22e-05	5	63	2	26042770
Pubmed	Inactivation of specific β cell transcription factors in type 2 diabetes.	PDX1 LEPR	3.22e-05	5	63	2	23863625
Pubmed	Planar cell polarity pathway regulates nephrin endocytosis in developing podocytes.	FZD3 WT1	3.22e-05	5	63	2	23824190
Pubmed	Insulin stimulates adipogenesis through the Akt-TSC2-mTORC1 pathway.	RPTOR TSC2	3.22e-05	5	63	2	19593385
Pubmed	Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis.	SPI1 FZD3 FZD2	4.21e-05	37	63	3	18800919
Pubmed	Direct interaction between NHERF1 and Frizzled regulates β-catenin signaling.	FZD3 FZD2	4.82e-05	6	63	2	20802536
Pubmed	An intrinsic gut leptin-melanocortin pathway modulates intestinal microsomal triglyceride transfer protein and lipid absorption.	VWF LEPR	4.82e-05	6	63	2	20164094
Pubmed	Transcription factor PU.1 is expressed in white adipose and inhibits adipocyte differentiation.	SPI1 LEPR	4.82e-05	6	63	2	18463231
Pubmed	Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.	EPHA2 EPHA5	4.82e-05	6	63	2	7973638
Pubmed	Opposite physiological and pathological mTORC1-mediated roles of the CB1 receptor in regulating renal tubular function.	RPTOR TSC2	4.82e-05	6	63	2	35379807
Pubmed	mTORC1 feedback to AKT modulates lysosomal biogenesis through MiT/TFE regulation.	RPTOR TSC2	4.82e-05	6	63	2	31527310
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	ATN1 FAT3	6.74e-05	7	63	2	22510986
Pubmed	The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner.	RPTOR TSC2	6.74e-05	7	63	2	19047368
Pubmed	The metabolic regulator mTORC1 controls terminal myeloid differentiation.	RPTOR TSC2	6.74e-05	7	63	2	28763796
Pubmed	Molecular characterization of a testis-specific estrogen sulfotransferase and aberrant liver expression in obese and diabetogenic C57BL/KsJ-db/db mice.	SPI1 LEPR	6.74e-05	7	63	2	7750469
Pubmed	Cell-type-dependent regulation of mTORC1 by REDD1 and the tumor suppressors TSC1/TSC2 and LKB1 in response to hypoxia.	RPTOR TSC2	6.74e-05	7	63	2	21383064
Pubmed	Cardiac endothelial cells express Wilms' tumor-1: Wt1 expression in the developing, adult and infarcted heart.	VWF WT1	6.74e-05	7	63	2	25681586
Pubmed	Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice.	WT1 MADCAM1	6.74e-05	7	63	2	15342464
Pubmed	Energy balance, the PI3K-AKT-mTOR pathway genes, and the risk of bladder cancer.	RPTOR TSC2	6.74e-05	7	63	2	20354165
Pubmed	Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.	TSC2 LEPR	6.74e-05	7	63	2	36198696
Pubmed	Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice.	VWA5A DACT2 CPM	8.68e-05	47	63	3	15172686
Pubmed	Identification of a novel lncRNA (G3R1) regulated by GLIS3 in pancreatic β-cells.	PDX1 LEPR	8.98e-05	8	63	2	32668405
Pubmed	Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.	FZD3 FZD2	8.98e-05	8	63	2	19388021
Pubmed	Retinoblastoma promotes definitive erythropoiesis by repressing Id2 in fetal liver macrophages.	VWF SPI1	8.98e-05	8	63	2	15616565
Pubmed	Degenerate PCR-based cloning method for Eph receptors and analysis of their expression in the developing murine central nervous system and vasculature.	EPHA2 EPHA5	1.15e-04	9	63	2	11403717
Pubmed	Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.	FZD3 FZD2	1.15e-04	9	63	2	19038973
Pubmed	Autonomous and non-autonomous Shh signalling mediate the in vivo growth and guidance of mouse retinal ganglion cell axons.	BOC HHIP	1.15e-04	9	63	2	18832395
Pubmed	Embryonic expression of EphA receptor genes in mice supports their candidacy for involvement in cleft lip and palate.	EPHA2 EPHA5	1.44e-04	10	63	2	25073978
Pubmed	EphA receptors inhibit anti-CD3-induced apoptosis in thymocytes.	EPHA2 EPHA5	1.44e-04	10	63	2	16547242
Pubmed	Expression of Frizzled genes in developing and postnatal hair follicles.	FZD3 FZD2	1.44e-04	10	63	2	15245425
Pubmed	HOXA13 directly regulates EphA6 and EphA7 expression in the genital tubercle vascular endothelia.	EPHA2 EPHA5	1.44e-04	10	63	2	17304517
Pubmed	Essential roles of mesenchyme-derived beta-catenin in mouse Müllerian duct morphogenesis.	FZD3 FZD2	1.44e-04	10	63	2	17532316
Pubmed	Mesenchymal Hox6 function is required for mouse pancreatic endocrine cell differentiation.	FZD3 PDX1 FZD2	1.71e-04	59	63	3	26450967
Pubmed	Frizzled-9 impairs acetylcholine receptor clustering in skeletal muscle cells.	FZD3 FZD2	1.76e-04	11	63	2	24860427
Pubmed	mTORC1 activity is essential for erythropoiesis and B cell lineage commitment.	SPI1 RPTOR	1.76e-04	11	63	2	31729420
Pubmed	Molecular determinants of WNT9b responsiveness in nephron progenitor cells.	FZD3 FZD2	1.76e-04	11	63	2	30978219
Pubmed	Partial interchangeability of Fz3 and Fz6 in tissue polarity signaling for epithelial orientation and axon growth and guidance.	FZD3 FZD2	1.76e-04	11	63	2	25294940
Pubmed	Expression of Frizzled5, Frizzled7, and Frizzled10 during early mouse development and interactions with canonical Wnt signaling.	FZD3 FZD2	1.76e-04	11	63	2	17576136
Pubmed	Formation of persistent hyperplastic primary vitreous in ephrin-A5-/- mice.	EPHA2 EPHA5	1.76e-04	11	63	2	24550361
Pubmed	Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.	EPHA2 EPHA5	1.76e-04	11	63	2	15517401
Pubmed	Distinct but redundant expression of the Frizzled Wnt receptor genes at signaling centers of the developing mouse brain.	FZD3 FZD2	1.76e-04	11	63	2	17582687
Pubmed	MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy.	RPTOR TSC2	1.76e-04	11	63	2	28059666
Pubmed	Rheb binds and regulates the mTOR kinase.	RPTOR TSC2	2.11e-04	12	63	2	15854902
Pubmed	EphrinA-EphA receptor interactions in mouse spinal neurulation: implications for neural fold fusion.	EPHA2 EPHA5	2.11e-04	12	63	2	19247962
Pubmed	Characterization of a novel Hoxa5eGFP mouse line.	WT1 PDX1	2.11e-04	12	63	2	36577717
Pubmed	Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.	FOXB1 RNF111	2.11e-04	12	63	2	11298452
Pubmed	Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function.	FZD3 PDX1	2.11e-04	12	63	2	16186384
Pubmed	A glycolytic shift in Schwann cells supports injured axons.	RPTOR TSC2	2.11e-04	12	63	2	32807950
Pubmed	Serum Response Factor Is Essential for Maintenance of Podocyte Structure and Function.	VWF WT1	2.49e-04	13	63	2	29114040
Pubmed	Tsc1 Haploinsufficiency Leads to Pax2 Dysregulation in the Developing Murine Cerebellum.	RPTOR TSC2	2.49e-04	13	63	2	35645731
Pubmed	ULK1 inhibits the kinase activity of mTORC1 and cell proliferation.	RPTOR TSC2	2.49e-04	13	63	2	21795849
Pubmed	The splanchnic mesodermal plate directs spleen and pancreatic laterality, and is regulated by Bapx1/Nkx3.2.	WT1 PDX1	2.49e-04	13	63	2	15329346
Pubmed	mTORC1 phosphorylates UVRAG to negatively regulate autophagosome and endosome maturation.	RPTOR TSC2	2.49e-04	13	63	2	25533187
Pubmed	Eph-ephrin A system regulates murine blastocyst attachment and spreading.	EPHA2 EPHA5	2.49e-04	13	63	2	17039519
Pubmed	Molecular specification and patterning of progenitor cells in the lateral and medial ganglionic eminences.	BOC ADAMTS5	2.49e-04	13	63	2	18799682
Pubmed	EphA family gene expression in the developing mouse neocortex: regional patterns reveal intrinsic programs and extrinsic influence.	EPHA2 EPHA5	2.49e-04	13	63	2	12528186
Pubmed	Tbx6 controls left-right asymmetry through regulation of Gdf1.	FZD3 FZD2	2.49e-04	13	63	2	29650695
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	COPA EPHA2 TSC2 ZCCHC2 KIAA2013	2.62e-04	313	63	5	38270169
Pubmed	Deficiency of the planar cell polarity protein Vangl2 in podocytes affects glomerular morphogenesis and increases susceptibility to injury.	FZD3 WT1	2.90e-04	14	63	2	25145929
Pubmed	Ephrin Ligands and Eph Receptors Show Regionally Restricted Expression in the Developing Palate and Tongue.	EPHA2 EPHA5	2.90e-04	14	63	2	26941654
Pubmed	A role for the EphA family in the topographic targeting of vomeronasal axons.	EPHA2 EPHA5	2.90e-04	14	63	2	11222144
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RPTOR TSC2	2.90e-04	14	63	2	28716898
Pubmed	Nkx2.2-repressor activity is sufficient to specify alpha-cells and a small number of beta-cells in the pancreatic islet.	TLE4 PDX1	2.90e-04	14	63	2	17202186
Pubmed	Git1-PGK1 interaction achieves self-protection against spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling.	COPA EPHA2	3.34e-04	15	63	2	36963288
Pubmed	Combined activities of hedgehog signaling inhibitors regulate pancreas development.	HHIP PDX1	3.34e-04	15	63	2	12917290
Pubmed	Genetic evidence that Celsr3 and Celsr2, together with Fzd3, regulate forebrain wiring in a Vangl-independent manner.	FOXB1 FZD3	3.34e-04	15	63	2	25002511
Pubmed	The septum transversum mesenchyme induces gall bladder development.	WT1 PDX1	3.34e-04	15	63	2	23951403
Pubmed	Dickkopf-1 (DKK1) reveals that fibronectin is a major target of Wnt signaling in branching morphogenesis of the mouse embryonic lung.	FZD3 FZD2	3.34e-04	15	63	2	15617677
Pubmed	Fgfr2 is integral for bladder mesenchyme patterning and function.	BOC HHIP	3.34e-04	15	63	2	28052872
Pubmed	Endothelial cell interactions initiate dorsal pancreas development by selectively inducing the transcription factor Ptf1a.	WT1 PDX1	3.81e-04	16	63	2	14736742
Pubmed	GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling.	HHIP PDX1	3.81e-04	16	63	2	26932670
Pubmed	Apical Restriction of the Planar Cell Polarity Component VANGL in Pancreatic Ducts Is Required to Maintain Epithelial Integrity.	FZD3 PDX1	3.81e-04	16	63	2	32460029
Pubmed	Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.	EPHA2 EPHA5	3.81e-04	16	63	2	8755474
Pubmed	Disruption of segmental neural crest migration and ephrin expression in delta-1 null mice.	EPHA2 EPHA5	4.32e-04	17	63	2	12217323
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	SPATA7 SAG PCARE	4.37e-04	81	63	3	20301590
Pubmed	Dual Effect of Raptor on Neonatal β-Cell Proliferation and Identity Maintenance.	RPTOR PDX1	4.85e-04	18	63	2	31345937
Pubmed	Groucho co-repressor proteins regulate β cell development and proliferation by repressing Foxa1 in the developing mouse pancreas.	TLE4 PDX1	4.85e-04	18	63	2	33658226
GeneFamily	Sterile alpha motif domain containing	EPHA2 SCML1 CNKSR2 EPHA5	5.59e-05	88	43	4	760
GeneFamily	G protein-coupled receptors, Class F frizzled	FZD3 FZD2	3.00e-04	11	43	2	286
GeneFamily	Fibronectin type III domain containing\|Sterile alpha motif domain containing\|EPH receptors	EPHA2 EPHA5	4.94e-04	14	43	2	1095
Coexpression	BENPORATH_ES_WITH_H3K27ME3	CACNA1B HHIP FOXB1 SLC9A3 SLC26A4 WT1 PDX1 GAB3 CPM FZD2 RFX4 MADCAM1 EPHA5	1.37e-06	1115	61	13	M10371
Coexpression	BENPORATH_PRC2_TARGETS	CACNA1B HHIP FOXB1 SLC9A3 SLC26A4 WT1 PDX1 FZD2 EPHA5	1.84e-05	650	61	9	M8448
Coexpression	BENPORATH_SUZ12_TARGETS	CACNA1B HHIP FOXB1 SLC9A3 SLC26A4 WT1 PDX1 ADAMTS5 FZD2 MGAT5B EPHA5	2.36e-05	1035	61	11	M9898
Coexpression	BENPORATH_EED_TARGETS	CACNA1B HHIP FOXB1 SLC9A3 SLC26A4 WT1 PDX1 ADAMTS5 ZCCHC2 FZD2 EPHA5	2.91e-05	1059	61	11	M7617
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500	FOXB1 FZD3 FAT3 C3orf70 NLGN1 HID1 RFX4 MGAT5B	7.59e-05	498	60	8	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000	CACNA1B VWF UBE2G2 FZD3 VWA5A IRF2BPL NLGN1 CPM RFX4 MADCAM1 EPHA5	7.70e-05	973	60	11	Facebase_RNAseq_e9.5_Olfactory Placode_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Olfactory Pit_top-relative-expression-ranked_1000	CACNA1B VWF FZD3 VWA5A SCN9A IRF2BPL NLGN1 CPM MADCAM1 CEP97 EPHA5	8.52e-05	984	60	11	Facebase_RNAseq_e10.5_Olfactory Pit_1000
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000	SPATA7 FOXB1 FZD3 FAT3 C3orf70 NLGN1 HID1 RFX4 MGAT5B CEP97 EPHA5	8.91e-05	989	60	11	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-unknown\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD3 SCN9A CNKSR2 CPM RFX4 EPHA5	2.57e-07	186	63	6	d8d559daff4aeef334d403fde4e3ee2e4a6086d0
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial-Schwann_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD3 SCN9A CNKSR2 CPM RFX4 EPHA5	2.92e-07	190	63	6	ff3dec5b45c6ea9b5319fb51a0198c6773b7be26
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Macroglial\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FZD3 SCN9A CNKSR2 CPM RFX4 EPHA5	2.92e-07	190	63	6	4971857eac9af17d66d673ed2ab7072639f60a10
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	BOC HHIP ATN1 EPHA2 DACT2 HID1	3.60e-07	197	63	6	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	15-Airway-Mesenchymal-Airway_Smooth_Muscle\|Airway / Age, Tissue, Lineage and Cell class	HHIP RPTOR FAT3 IL21R ADAMTS5	3.69e-06	165	63	5	531804467601e1ee1f771cffa21501f6d464ae10
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP EPHA2 DACT2 NLGN1	5.96e-06	182	63	5	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP EPHA2 DACT2 NLGN1	6.28e-06	184	63	5	d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	CACNA1B HHIP IL21R GAB3 ADAMTS5	7.16e-06	189	63	5	0abc7a4900cc9033bc1be69b770ccc54a6bf41b4
ToppCell	droplet-Liver-nan-3m-Myeloid-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP C3orf70 TSC2 RFX4	3.17e-05	127	63	4	39fa20a55de3af1a62ab5dfa4877879db3935ac2
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HHIP VWF SLC26A4 HID1	5.18e-05	144	63	4	3d880c140db4a0e7602bfddcb73a42a68c2848d5
ToppCell	COVID-19-lung-Mesothelial\|lung / Disease (COVID-19 only), tissue and cell type	BOC WT1 NLGN1 EPHA5	7.06e-05	156	63	4	e1f563869b3bf997eaa2e756e31b53db1a478903
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF MGAT5B MADCAM1 LEPR	7.79e-05	160	63	4	33050dc646762dc7e9dcc4a12c618e1ba1ce5a4d
ToppCell	390C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	INTS2 PIEZO1 PIAS2 CEP97	7.98e-05	161	63	4	2fe77af3b41e6eacb707a64feea18f9991618173
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B FAT3 SCN9A EPHA5	8.18e-05	162	63	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	390C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FOXB1 IL21R CEP97 LEPR	8.18e-05	162	63	4	45be019b50e3727fc9d3fad2ff78e74e4f2d746b
ToppCell	390C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	FOXB1 IL21R CEP97 LEPR	8.18e-05	162	63	4	fbb0cc2b1434a340dc35058b77c73ea61004c252
ToppCell	Influenza_Severe-pDC\|Influenza_Severe / Disease group and Cell class	FZD3 EPHA2 SCN9A HID1	8.98e-05	166	63	4	b43a5cd4d28118cf6e56a435deb8ea9435608a90
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WT1 ADAMTS5 FZD2 MGAT5B	9.63e-05	169	63	4	87116c33c5ca8cb1862e103e5607b1df4d264569
ToppCell	3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	BOC NLGN1 ADAMTS5 LEPR	1.03e-04	172	63	4	e37c0b5b547a7345179ab258dd2141fec7064c17
ToppCell	ASK428-Immune-B_cell\|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq	BOC FZD3 HID1 LEPR	1.08e-04	174	63	4	b5a7a612a515736cf3489afd0f6ad2054d54526f
ToppCell	5'-GW_trimst-2-LymphNode-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF EPYC MADCAM1 LEPR	1.08e-04	174	63	4	6b5ff1cc5fe6705f7ea70b5a892dfbf91e32288d
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BOC SLC26A4 CNKSR2 NLGN1	1.10e-04	175	63	4	ff0789f5913c9f3c49159e40b1ec3d2ff175ec9f
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	BOC FZD3 HID1 LEPR	1.10e-04	175	63	4	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	normal_Lymph_Node-B_lymphocytes-GrB-secreting_B_cells\|normal_Lymph_Node / Location, Cell class and cell subclass	FZD3 EPHA2 SCN9A GAB3	1.10e-04	175	63	4	29fbdfe1d3bfcb063be2bced0128a33176c5b78f
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	BOC SLC26A4 CNKSR2 NLGN1	1.10e-04	175	63	4	21f8f11a8b874d4f7c47931010a2535f2a5a3373
ToppCell	Endothelial-A-IPF_04\|World / lung cells shred on cell class, cell subclass, sample id	VWF NLGN1 MGAT5B LEPR	1.18e-04	178	63	4	2f2602b9305d55f25afa9861dd6c6347ae179337
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP DACT2 NLGN1	1.20e-04	179	63	4	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP DACT2 NLGN1	1.23e-04	180	63	4	b798a3fa2dd15b68aa4267f665559527043dcc07
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP FAT3 ADAMTS5	1.31e-04	183	63	4	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	facs-Liver-Non-hepatocytes-24m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC HHIP FZD3 WT1	1.31e-04	183	63	4	ebe369dc80c4fbf8f4dbe947147f8c47507ffb60
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 SCN9A CNKSR2 EPHA5	1.34e-04	184	63	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 SCN9A CNKSR2 EPHA5	1.34e-04	184	63	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FAT3 SCN9A CNKSR2 EPHA5	1.34e-04	184	63	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP DACT2 NLGN1	1.34e-04	184	63	4	ab2f06906fc7a9931dfa0864ef506832b07fb93e
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC26A4 SCN9A PCARE ADAMTS5	1.39e-04	186	63	4	948815663c212c4311329d503b5991cbbbff9808
ToppCell	LPS_only-Epithelial_alveolar\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	HHIP EPHA2 DACT2 NLGN1	1.39e-04	186	63	4	e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP DACT2 NLGN1	1.39e-04	186	63	4	e83718fabb057100835d3357df407f283d23fe16
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF MGAT5B MADCAM1 LEPR	1.42e-04	187	63	4	d6765854154557794815514c0aa355bc74b8523e
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP DACT2 NLGN1	1.45e-04	188	63	4	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	HHIP IL21R C3orf70 ADAMTS5	1.45e-04	188	63	4	f54b063025d80de631382bf5326bc40aab7f7d00
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP FAT3 ADAMTS5	1.48e-04	189	63	4	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
ToppCell	wk_15-18-Mesenchymal-Myofibro_&_SMC-Myofibro_1\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	CACNA1B HHIP FAT3 IL21R	1.51e-04	190	63	4	d24af6af3271e34afab744352afd28be8a7cc5c3
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_ASM_(13)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	HHIP IL21R C3orf70 ADAMTS5	1.51e-04	190	63	4	938d1f66094b1c94606e0d40213a39e5112f3322
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC26A4 SCN9A PCARE ADAMTS5	1.51e-04	190	63	4	39ab890104b4264c68a968f920f4ccd84f0bc681
ToppCell	Fetal_29-31_weeks-Mesenchymal-matrix_fibroblast_2_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	BOC MTHFD1L WT1 NLGN1	1.51e-04	190	63	4	0fea33f2dc1efa23aaa2da1c318482a52a313ff1
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF TLE4 SCN9A LEPR	1.51e-04	190	63	4	106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HHIP EPHA2 DACT2 CPM	1.54e-04	191	63	4	34cc997e4e5c727495f321e6807a84aa124da486
ToppCell	droplet-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BOC DACT2 ADAMTS5 FZD2	1.54e-04	191	63	4	b51e0f5d1b93f526160c904e9091313a5364f3a7
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	BOC HHIP FAT3 ADAMTS5	1.54e-04	191	63	4	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	HHIP NLGN1 ADAMTS5 FZD2	1.54e-04	191	63	4	24dc77ee8de01b42559f92721655f4281b114e17
ToppCell	Adult-Mesenchymal-matrix_fibroblast_2_cell\|Adult / Lineage, Cell type, age group and donor	BOC NLGN1 ADAMTS5 LEPR	1.57e-04	192	63	4	d21f0f577156f17c899b08871046a26b88aea011
ToppCell	11.5-Airway-Mesenchymal-Cartilage\|Airway / Age, Tissue, Lineage and Cell class	BOC EPYC C3orf70 CPM	1.60e-04	193	63	4	d4779d92a4dd4b8b656383e6f4fce76d3bd70931
ToppCell	Tracheal-NucSeq-Stromal-Peri/Epineurial_-NAF_endoneurial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FOXB1 SCN9A NLGN1 MGAT5B	1.60e-04	193	63	4	549a0b750c860b615aff767ad04c9a9d20f802f0
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B FAT3 DACT2 EPHA5	1.60e-04	193	63	4	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	11.5-Airway-Epithelial-Bud_tip_progenitor\|Airway / Age, Tissue, Lineage and Cell class	EPHA2 DACT2 HID1 CPM	1.60e-04	193	63	4	f0a07bb221a497a9f7cc706045d5205269be4515
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B FAT3 DACT2 EPHA5	1.60e-04	193	63	4	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	Control-Endothelial-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF TLE4 SCN9A LEPR	1.60e-04	193	63	4	aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCell	Control-Endothelial\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	VWF TLE4 SCN9A LEPR	1.60e-04	193	63	4	c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCell	facs-Lung-nan-3m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC HHIP ADAMTS5 FZD2	1.60e-04	193	63	4	d9c20a092b507c43fcf7ccb04073fecd27d1749c
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BOC HHIP WT1 RNASEK	1.60e-04	193	63	4	68089ba4123e2f9bea9aae0023a844b5a57bfc0e
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-J_(Lipofibroblast)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	EPHA2 SCN9A DACT2 WT1	1.64e-04	194	63	4	784b15119c91ace33d34bfb3d68c182566a3e9a8
ToppCell	3'-Adult-Appendix-Endothelial-blood_vessel_EC-Mature_venous_EC\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHA2 C3orf70 CEP97 LEPR	1.67e-04	195	63	4	6a0460d949ccda7c9fe76870d3ee6c2f60677d61
ToppCell	wk_20-22-Mesenchymal-Myofibro_&_SMC-Late_airway_SMC\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	BOC HHIP C3orf70 ADAMTS5	1.67e-04	195	63	4	4dba732c8d8ecf0ed9ece1814dc4060402199ed9
ToppCell	11.5-Distal-Endothelial\|Distal / Age, Tissue, Lineage and Cell class	VWF HID1 MADCAM1 LEPR	1.67e-04	195	63	4	efdede0f476883ffddd247fa7bc6449e7932613e
ToppCell	11.5-Distal-Endothelial-Endothelial\|Distal / Age, Tissue, Lineage and Cell class	VWF HID1 MADCAM1 LEPR	1.67e-04	195	63	4	1e9b52b201ab6c78f536609e2afe1d680c71a6e7
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	VWF MGAT5B MADCAM1 LEPR	1.67e-04	195	63	4	527a5a50d6e2cbbbd64d11609e5cde2e33f14797
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1B FAT3 DACT2 CNKSR2	1.67e-04	195	63	4	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	11.5-Distal-Epithelial-Bud_tip_progenitor\|Distal / Age, Tissue, Lineage and Cell class	EPHA2 DACT2 HID1 CPM	1.70e-04	196	63	4	42eae265e2f2082983d8c2607c7f6a53a526d124
ToppCell	facs-Lung-nan\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC HHIP COPA ADAMTS5	1.70e-04	196	63	4	b05f77f3990b662682ffeaf0e4c2fb190e0a6e65
ToppCell	facs-Lung-nan-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOC HHIP COPA ADAMTS5	1.70e-04	196	63	4	787c6cd92035e0b1108c2c086c42a229016e476b
ToppCell	Influenza-Influenza_Severe-Myeloid-pDC\|Influenza_Severe / Disease, condition lineage and cell class	FZD3 MTHFD1L SCN9A HID1	1.74e-04	197	63	4	e8e6f71e6dc8a695e4321a18543c1df63dd62f3e
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	BOC HHIP EPHA2 DACT2	1.74e-04	197	63	4	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	VWF ZCCHC2 MADCAM1 LEPR	1.74e-04	197	63	4	88859b7b24b36afab4a684fd7abf0e0f8e5b525c
ToppCell	distal-Hematologic-IGSF21+_Dendritic\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	SPI1 SCN9A CPM FZD2	1.74e-04	197	63	4	a357ee2ba9100dfaeba9ecae8138a2776bb54b0b
ToppCell	wk_08-11-Mesenchymal-Myofibro_&_SMC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	HHIP IL21R C3orf70 ADAMTS5	1.77e-04	198	63	4	637f11e292b90d86cdc0d0d828eb26f38289c25b
ToppCell	severe-pDC\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HHIP FZD3 EPHA2 SCN9A	1.77e-04	198	63	4	22da4a29b9ff8b94d98bc69b4632a2a58d5dd9e6
ToppCell	COPD-Stromal-Fibroblast\|World / Disease state, Lineage and Cell class	WT1 NLGN1 ADAMTS5 LEPR	1.77e-04	198	63	4	2f13c0b3372af53d1bd85f9546f315c878580a71
ToppCell	severe-pDC\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	HHIP FZD3 EPHA2 SCN9A	1.77e-04	198	63	4	3c4820a8391088682fb3e47b914f872533bae227
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-intermediate_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	VWF HID1 MADCAM1 LEPR	1.77e-04	198	63	4	75270600b5b29187dfa86f01f8f927ae0621cda4
ToppCell	distal-3-mesenchymal-Adventitial_Fibroblast\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BOC DACT2 ADAMTS5 LEPR	1.80e-04	199	63	4	547a7c30abc730af2670aee00c7a6af60426c9ac
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BOC NLGN1 ADAMTS5 LEPR	1.80e-04	199	63	4	f835e7ffe976843b0edbf695762d463da85793f3
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macrophage_intravascular\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SPI1 SCN9A GAB3 CPM	1.80e-04	199	63	4	9545ac59c8d75f5747dff86cb511a149dc103b31
ToppCell	Biopsy_Control_(H.)-Mesenchymal-Mesothelial_cells\|Biopsy_Control_(H.) / Sample group, Lineage and Cell type	BOC WT1 DIRC1 EPHA5	1.80e-04	199	63	4	ca970114b5aef4518ce580897a62ac88688b2671
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_1-AF2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BOC NLGN1 ADAMTS5 LEPR	1.80e-04	199	63	4	993fa050a095017135a6e723c77cd38b9d782e58
ToppCell	distal-mesenchymal-Adventitial_Fibroblast-3\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	BOC DACT2 NLGN1 ADAMTS5	1.80e-04	199	63	4	6e8a44e46b46e87b81dbfc56fcbbcde166fd00fe
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related\|10w / Sample Type, Dataset, Time_group, and Cell type.	BOC EPHA2 PCARE RFX4	1.84e-04	200	63	4	8f5d98f962ddd8c4658c89ff8a2894de1228562a
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2--L2-4\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC26A4 SCN9A PCARE ADAMTS5	1.84e-04	200	63	4	c65e6336725856c4b5f6aeba1cf86a23ec815d34
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-OPC_related-Oligodendrocyte/OPC\|10w / Sample Type, Dataset, Time_group, and Cell type.	BOC EPHA2 PCARE RFX4	1.84e-04	200	63	4	345f1eac498cc87fd7bf08e7312608b2d6fe1dd7
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BOC WT1 NLGN1 LEPR	1.84e-04	200	63	4	74e74123ea7bf38d337a3a0248a6a51437c6ab42
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC26A4 SCN9A PCARE ADAMTS5	1.84e-04	200	63	4	117a25b3b9cdbc2e198381350a8362bee25e82e7
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	BOC WT1 ADAMTS5 LEPR	1.84e-04	200	63	4	56536236a7012efdb28f85b40e464f3da3e87ce8
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-WFDC2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC26A4 SCN9A PCARE ADAMTS5	1.84e-04	200	63	4	d459e51507bf26865e6e7e04411379ec82a3edf8
Disease	Retinitis pigmentosa	SPATA7 SAG PCARE	4.23e-04	74	58	3	cv:C0035334
Disease	Disorder of eye	SPATA7 SAG WT1 PCARE	8.11e-04	212	58	4	C0015397
Disease	anxiety disorder (implicated_via_orthology)	SCN9A TSC2	8.55e-04	22	58	2	DOID:2030 (implicated_via_orthology)
Disease	Pancreatic Neoplasm	WT1 PDX1 TSC2	1.02e-03	100	58	3	C0030297
Disease	Malignant neoplasm of pancreas	WT1 PDX1 TSC2	1.08e-03	102	58	3	C0346647
Disease	Retinitis Pigmentosa	SPATA7 SAG PCARE	1.14e-03	104	58	3	C0035334
Disease	Streptozotocin Diabetes	SLC9A3 PDX1 LEPR	1.27e-03	108	58	3	C0038433
Disease	Diabetes Mellitus, Experimental	SLC9A3 PDX1 LEPR	1.27e-03	108	58	3	C0011853
Disease	Alloxan Diabetes	SLC9A3 PDX1 LEPR	1.27e-03	108	58	3	C0002152
Disease	Ciliopathies	SPATA7 PCARE TSC2	1.34e-03	110	58	3	C4277690
Disease	leiomyoma (is_marker_for)	TSC2 FZD2	1.39e-03	28	58	2	DOID:127 (is_marker_for)
Disease	Squamous cell carcinoma of lung	EPHA2 EPHA5	1.81e-03	32	58	2	C0149782
Disease	Acute Myeloid Leukemia, M1	SPI1 WT1 TSC2	1.93e-03	125	58	3	C0026998
Disease	Acute Myeloid Leukemia (AML-M2)	SPI1 WT1 TSC2	1.93e-03	125	58	3	C1879321

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRFMPARPCSLYTCT	CA5B	26	Q9Y2D0
PMFSSYPLPNCYLSD	TBC1D32	901	Q96NH3
AIYRSCSLMPCPPNG	ADAMTS5	611	Q9UNA0
RLPSPMDCPAALYQL	EPHA5	896	P54756
APYRDLPASLSAPMS	ATN1	1121	P54259
PFLLTFPDYLPCSVM	SAG	121	P10523
FPDYLPCSVMLQPAP	SAG	126	P10523
LPPDSPRYCMISDLF	C3orf70	116	A6NLC5
STMPGLPTRPCFYDI	MTHFD1L	951	Q6UB35
PRPIVPYSSMFCLSP	CACNA1B	1121	Q00975
PYSSMFCLSPTNLLR	CACNA1B	1126	Q00975
YPFNSPTSRMEPCLM	RFX4	646	Q33E94
TPVPPALYCQATMRL	MADCAM1	196	Q13477
SLNLPCRFSPMYPTA	GAB3	371	Q8WWW8
GSCPLTMPLPFDLIY	MGAT5B	351	Q3V5L5
TPQAYMCLPRLPVGS	EPYC	306	Q99645
PQPYLDASCPMLPTA	IRF2BPL	496	Q9H1B7
PEFSASPPACLYMGR	PDX1	26	P52945
PCIFMYARPARTFPI	OR4A47	251	Q6IF82
SLAIPCPAHYTPRMS	FZD2	501	Q14332
CPAHYTPRMSPDFTV	FZD2	506	Q14332
MPTLPSLVSFCRAFP	INTS2	1101	Q9H0H0
SCMPPNSTYDYFLLP	LEPR	36	P48357
TACPPDYTLAMRRSP	NLGN1	796	Q8N2Q7
LAFSAMQPVPAAYPL	FOXB1	186	Q99853
MCSPASPKILYRNPR	BTBD18	1	B2RXH4
GFPRSALPPSCPYTM	BOC	891	Q9BWV1
APGRSCSESTLYPMP	DACT2	556	Q5SW24
SNPSCPMIPLYRNLP	CPM	406	P14384
PAFMCYVPSPVLASV	ENTR1	56	Q96C92
PCVMATPSIPGFDYR	CEP97	206	Q8IW35
QALPCLPSMYGYPNR	COPA	971	P53621
ASMPCTRPPSAPHYL	EPHA2	321	P29317
PVRPMAYTPCFQSDS	FAT3	4231	Q8TDW7
SPPCPNMYFRREELS	FZD3	186	Q9NPG1
DHPYCSPPMTFSPAL	HCFC1R1	76	Q9NWW0
PSPERFFMPLYKGCS	IL21R	271	Q9HBE5
VSCYLPPLSNAHPMC	DIRC1	26	Q969H9
YPLSCIRSQPMQFFP	C18orf63	266	Q68DL7
NCIMPPRFPKYTGLA	PCARE	761	A6NGG8
PQYCPPMFLDSLTSP	PIAS2	561	O75928
LPPDTYFRFNPVMCE	PNPLA8	701	Q9NP80
PSNLPRPSFCMEEYQ	SCML1	151	Q9UN30
LLTCFSEAMYLPPAP	HID1	211	Q8IV36
IPYSPGTFCRLMPFR	SLC9A3	791	P48764
FSLNNPMYVRSPCDP	PPP1R32	321	Q7Z5V6
NATPALYMLSPFSPL	SCN9A	101	Q15858
RMCLQYPSLSPAQPS	SPI1	116	P17947
MCNVPYSIPRSNPHF	HHIP	401	Q96QV1
NCTPVSSPRLPPTYM	RPTOR	361	Q8N122
LAFLPPDPTYTLMCD	ABHD17B	26	Q5VST6
PRPPSMSCASPYVEA	CNKSR2	711	Q8WXI2
PMYRVPSFFTLPSIC	ZCCHC2	1041	Q9C0B9
PDFCAMSCPPSLVYN	VWF	2196	P04275
SCRHYMPPPYASLTR	RNF111	641	Q6ZNA4
PQLPEYSCSYMVSRP	SLC26A4	11	O43511
LASSLRTPMAVPCPY	TLE4	356	Q04727
RMFPNAPYLPSCLES	WT1	126	P19544
SPRAMCQYSLKPPST	SPATA7	341	Q9P0W8
RPPSASQPRGELMCY	VWA5A	636	O00534
PPSLNPDYIQRPYCM	ZC2HC1B	111	Q5TFG8
PYPRFRPMASCLSTV	PIEZO1	846	Q92508
PRRSPTPFFMASLLC	RNASEK	31	Q6P5S7
FYLQPERSCVPNSPM	ZMYM4	1491	Q5VZL5
PTSVLPSFYQAMACP	TSC2	316	P49815
PLDYPLSPPKMRFTC	UBE2G2	61	P60604
LYYMLSCSPAPLLSP	KIAA2013	366	Q8IYS2