Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	3.20e-13	1459	57	24	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF568 ZFX	1.49e-12	1412	57	23	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF37A ZNF780A ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	1.01e-11	1244	57	21	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF37A ZNF780A ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	1.51e-11	1271	57	21	GO:0000987
GeneOntologyMolecularFunction	histone H3K36 methyltransferase activity	SETD2 NSD3	6.12e-04	13	57	2	GO:0046975
Domain	-	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	2.78e-20	679	56	24	3.30.160.60
Domain	ZINC_FINGER_C2H2_2	ZNF12 ZNF708 ZC3H7A ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	3.18e-20	775	56	25	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF12 ZNF708 ZC3H7A ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	3.38e-20	777	56	25	PS00028
Domain	zf-C2H2	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	4.46e-20	693	56	24	PF00096
Domain	Znf_C2H2/integrase_DNA-bd	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	4.62e-20	694	56	24	IPR013087
Domain	Znf_C2H2-like	ZNF12 ZNF708 ZC3H7A ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	6.05e-20	796	56	25	IPR015880
Domain	Znf_C2H2	ZNF12 ZNF708 ZC3H7A ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	7.93e-20	805	56	25	IPR007087
Domain	ZnF_C2H2	ZNF12 ZNF708 ZC3H7A ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	8.68e-20	808	56	25	SM00355
Domain	KRAB	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF540 ZNF432 ZNF195 ZNF578 ZNF215 ZNF568	2.17e-16	358	56	17	PS50805
Domain	KRAB	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF540 ZNF432 ZNF195 ZNF578 ZNF215 ZNF568	3.59e-16	369	56	17	SM00349
Domain	KRAB	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF540 ZNF432 ZNF195 ZNF578 ZNF215 ZNF568	3.75e-16	370	56	17	IPR001909
Domain	KRAB	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF550 ZNF37A ZNF780A ZNF337 ZNF540 ZNF432 ZNF195 ZNF578 ZNF215 ZNF568	4.94e-15	358	56	16	PF01352
Domain	zf-C2H2_6	ZNF12 ZNF695 ZNF266 ZNF780A ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF107 ZNF501 ZNF568	6.61e-12	314	56	13	PF13912
Domain	Prtase_inh_Kunz-CS	EPPIN WFDC8 TFPI	2.02e-05	18	56	3	IPR020901
Domain	KU	EPPIN WFDC8 TFPI	2.02e-05	18	56	3	SM00131
Domain	BPTI_KUNITZ_2	EPPIN WFDC8 TFPI	2.39e-05	19	56	3	PS50279
Domain	Kunitz_BPTI	EPPIN WFDC8 TFPI	2.39e-05	19	56	3	PF00014
Domain	BPTI_KUNITZ_1	EPPIN WFDC8 TFPI	2.39e-05	19	56	3	PS00280
Domain	Kunitz_BPTI	EPPIN WFDC8 TFPI	4.33e-05	23	56	3	IPR002223
Domain	AWS	SETD2 NSD3	8.78e-05	5	56	2	PS51215
Domain	AWS_dom	SETD2 NSD3	8.78e-05	5	56	2	IPR006560
Domain	AWS	SETD2 NSD3	8.78e-05	5	56	2	SM00570
Domain	Post-SET_dom	SETD2 NSD3	1.03e-03	16	56	2	IPR003616
Domain	WAP	EPPIN WFDC8	1.03e-03	16	56	2	SM00217
Domain	PostSET	SETD2 NSD3	1.03e-03	16	56	2	SM00508
Domain	POST_SET	SETD2 NSD3	1.03e-03	16	56	2	PS50868
Domain	WAP	EPPIN WFDC8	1.03e-03	16	56	2	PF00095
Domain	Disintegrin_CS	ADAM28 ADAM22	1.03e-03	16	56	2	IPR018358
Domain	WAP	EPPIN WFDC8	1.17e-03	17	56	2	PS51390
Domain	ADAM_CR	ADAM28 ADAM22	1.31e-03	18	56	2	PF08516
Domain	-	WFDC8 TFPI	1.31e-03	18	56	2	4.10.410.10
Domain	-	ADAM28 ADAM22	1.62e-03	20	56	2	4.10.70.10
Domain	DISIN	ADAM28 ADAM22	1.79e-03	21	56	2	SM00050
Domain	Disintegrin	ADAM28 ADAM22	1.79e-03	21	56	2	PF00200
Domain	WAP_dom	EPPIN WFDC8	1.96e-03	22	56	2	IPR008197
Domain	ADAM_Cys-rich	ADAM28 ADAM22	2.95e-03	27	56	2	IPR006586
Domain	ACR	ADAM28 ADAM22	2.95e-03	27	56	2	SM00608
Domain	EGF_3	FBN1 C9 ADAM28 ADAM22	5.38e-03	235	56	4	PS50026
Domain	EGF	FBN1 ZNF578 ADAM28 ADAM22	5.38e-03	235	56	4	SM00181
Domain	Peptidase_M12B_N	ADAM28 ADAM22	6.09e-03	39	56	2	IPR002870
Domain	Pep_M12B_propep	ADAM28 ADAM22	6.09e-03	39	56	2	PF01562
Domain	DISINTEGRIN_1	ADAM28 ADAM22	6.40e-03	40	56	2	PS00427
Domain	ADAM_MEPRO	ADAM28 ADAM22	6.40e-03	40	56	2	PS50215
Domain	DISINTEGRIN_2	ADAM28 ADAM22	6.40e-03	40	56	2	PS50214
Domain	Reprolysin	ADAM28 ADAM22	6.40e-03	40	56	2	PF01421
Domain	Peptidase_M12B	ADAM28 ADAM22	6.40e-03	40	56	2	IPR001590
Domain	EGF-like_dom	FBN1 C9 ADAM28 ADAM22	6.58e-03	249	56	4	IPR000742
Domain	SET	SETD2 NSD3	6.72e-03	41	56	2	PF00856
Domain	Disintegrin_dom	ADAM28 ADAM22	6.72e-03	41	56	2	IPR001762
Domain	EGF_1	FBN1 C9 ADAM28 ADAM22	7.15e-03	255	56	4	PS00022
Domain	EGF-like_CS	FBN1 C9 ADAM28 ADAM22	7.75e-03	261	56	4	IPR013032
Domain	EGF_2	FBN1 C9 ADAM28 ADAM22	8.17e-03	265	56	4	PS01186
Domain	SET	SETD2 NSD3	8.40e-03	46	56	2	SM00317
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF12 ZNF708 ZNF585A ZNF266 ZNF550 ZNF37A ZNF337 SUPT5H ZNF540 ZNF432 ZNF195 ZNF215 MSTN ZNF568	6.64e-05	1387	45	14	M734
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF708 ZNF550 ZNF780A ZNF432 ZNF195 ZNF107	5.32e-07	181	57	6	37372979
Pubmed	An integrated physical map of 210 markers assigned to the short arm of human chromosome 11.	ZNF195 ZNF215	7.91e-06	3	57	2	7959730
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF695 ZNF195 ZNF107	1.48e-05	29	57	3	14563677
Pubmed	Multiple genes encoding zinc finger domains are expressed in human T cells.	ZNF12 ZNF708 ZNF37A	1.82e-05	31	57	3	2288909
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	SETD2 NSD3	2.63e-05	5	57	2	39390582
Pubmed	Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2.	EPPIN WFDC8	3.94e-05	6	57	2	12909348
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF585A ZNF695 ZNF107	7.29e-05	49	57	3	9630514
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN1 MSTN	7.34e-05	8	57	2	18339631
Pubmed	A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.	PRR14L SNRNP200 CHUK	1.40e-04	61	57	3	19875381
Pubmed	A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.	EPPIN WFDC8	2.37e-04	14	57	2	12206714
Pubmed	Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering.	ZNF708 ZNF37A	2.37e-04	14	57	2	2014798
Pubmed	Selective disruption of trigeminal sensory neurogenesis and differentiation in a mouse model of 22q11.2 deletion syndrome.	SCN11A FBN1	2.73e-04	15	57	2	33722956
Pubmed	The evolution of a genetic locus encoding small serine proteinase inhibitors.	EPPIN WFDC8	3.12e-04	16	57	2	15950183
Pubmed	Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation.	ZNF585A ZNF195 ZNF568	3.49e-04	83	57	3	20562864
Pubmed	Biochemical Reduction of the Topology of the Diverse WDR76 Protein Interactome.	FBN1 SUPT5H MCM5 SNRNP200	4.65e-04	219	57	4	31353912
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF12 ZNF266	5.43e-04	21	57	2	7865130
Pubmed	Rapid identification of 14-3-3-binding proteins by protein microarray analysis.	GSTM3 STAC	5.43e-04	21	57	2	16260042
Pubmed	ATRX promotes heterochromatin formation to protect cells from G-quadruplex DNA-mediated stress.	SETD2 SUPT5H	8.36e-04	26	57	2	34162889
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF540 MCM5 ZNF107 ZNF501 ZNF568	8.63e-04	451	57	5	36168627
Pubmed	USP7 Regulates Cytokinesis through FBXO38 and KIF20B.	ZNF780A ZNF217 BCL11A	9.28e-04	116	57	3	30804394
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF585A ZNF780A ZSCAN2 ZNF217 BCL11A ZFX	1.05e-03	709	57	6	22988430
Pubmed	Polymorphisms in genes involved in neurodevelopment may be associated with altered brain morphology in schizophrenia: preliminary evidence.	ADAM28 ADAM22	1.11e-03	30	57	2	19054571
Pubmed	The functional interactome landscape of the human histone deacetylase family.	SVIL ZSCAN2 ZNF217 BCL11A	1.30e-03	289	57	4	23752268
Pubmed	The DNA sequence and comparative analysis of human chromosome 20.	EPPIN ZNF337 DEFB123 ZNF217 WFDC8	1.58e-03	517	57	5	11780052
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF132 ZNF585A ZNF550 ZNF780A SUPT5H ZNF540 ZNF432 ZNF578 ZNF568	1.53e-05	1192	57	9	chr19q13
Cytoband	10p11.2	ZNF37A SVIL	4.22e-05	8	57	2	10p11.2
Cytoband	19q13.12	ZNF585A ZNF540 ZNF568	1.02e-04	72	57	3	19q13.12
Cytoband	20q13.12	EPPIN WFDC8	2.56e-03	60	57	2	20q13.12
Cytoband	19q13.41	ZNF432 ZNF578	4.28e-03	78	57	2	19q13.41
Cytoband	3p21.31	SETD2 ZNF501	6.93e-03	100	57	2	3p21.31
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	SETD2 ZNF501 DNAH1	7.18e-03	316	57	3	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chr2q32	MSTN TFPI	8.33e-03	110	57	2	chr2q32
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF12 ZNF708 ZNF132 ZNF630 ZNF585A ZNF695 ZNF266 ZNF550 ZNF37A ZNF780A ZNF337 ZNF652 ZNF540 ZNF432 ZNF195 ZNF578 ZSCAN2 ZNF215 ZNF217 BCL11A ZNF107 ZNF501 ZNF568 ZFX	5.62e-22	718	46	24	28
GeneFamily	WAP four-disulfide core domain containing\|Fibronectin type III domain containing	EPPIN WFDC8	9.44e-04	18	46	2	361
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	ADAM28 ADAM22	2.13e-03	27	46	2	47
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD2 NSD3	3.37e-03	34	46	2	487
Coexpression	NIKOLSKY_BREAST_CANCER_19Q13.1_AMPLICON	ZNF585A ZNF540 ZNF568	1.46e-05	22	57	3	M8692
Drug	Galanthamine hydrobromide [1953-04-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A	SETD2 ZNF652 ZNF195 ZNF217 ZFX TFPI	8.96e-06	194	57	6	4772_DN
Drug	Acetopromazine maleate salt [3598-37-6]; Up 200; 9uM; PC3; HT_HG-U133A	RPL10L PLA2R1 SCN11A ZSCAN2 ADAM22 ZFX	1.04e-05	199	57	6	4494_UP
Disease	liver cancer (is_marker_for)	SETD2 ADAM28	1.05e-04	9	51	2	DOID:3571 (is_marker_for)
Disease	phosphoglyceric acid measurement	NUBP1 ZNF107	3.92e-04	17	51	2	EFO_0010523
Disease	Bone Diseases, Developmental	NANS CHUK	1.00e-03	27	51	2	C0005941

Protein segments in the cluster

Peptide	Gene	Start	Entry
CQFKKAGMVCRPAKD	ADAM28	456	Q9UKQ2
LIPCKANDTMCGKLF	ADAM28	551	Q9UKQ2
SDGLCCKKCKFQPMG	ADAM22	486	Q9P0K1
CKKCKFQPMGTVCRE	ADAM22	491	Q9P0K1
MPKCPKCNKEVYFAE	CRIP1	1	P50238
VVENMSGFICPKCKK	NUBP1	226	P53384
KMLPEEKVCKYCGVS	LEKR1	16	Q6ZMV7
PYFIMPDKCKCVDFQ	MCM5	211	P33992
KKDPKCIFACEEMSG	CHUK	236	O15111
GKDVYKCEICKMPFS	BCL11A	796	Q9H165
KRFKKYFCMVPDCEG	GABRE	451	P78334
PKCLDEFPNLKAFMC	GSTM3	176	P21266
CGLQKKCEGGKAMLF	OCR1	46	Q9BZK8
KCVKQFKDMPACQEV	DNAH1	1066	Q9P2D7
NGKPFFKDINECKMI	FBN1	1021	P35555
CINNKMCCVKPKYQP	DEFB123	46	Q8N688
LMDGKCLCACPFKFE	C9	521	P02748
LCKPKDGEMLCENVK	PRR14L	1261	Q5THK1
GKKCLDLKQDVCEMP	EPPIN	66	O95925
FEDMVAKKCLIPDGC	RPL10L	181	Q96L21
LCKNPCAMFAAGEIK	SVIL	1096	O95425
DFLMQVDGKPKCCFF	MSTN	126	O14793
RMAKECGADCAKFQK	NANS	41	Q9NR45
CKKLVENGGMFVCKT	SUPT5H	626	O00267
LSPCQEKKGFICKME	PLA2R1	1366	Q13018
MKFNEFNKGGKCFCD	ZNF37A	91	P17032
FACQKKCMDPFQEPC	WFDC8	81	Q8IUA0
ECLIKCMDYGFIKPV	UNC45B	916	Q8IWX7
KKANSCDMCGPFLKD	ZNF132	111	P52740
ILMEEKPYKCEECGK	ZNF107	321	Q9UII5
EKPYECKECGKAFML	ZNF540	436	Q8NDQ6
EKPFKCKECGNVSCM	ZNF695	181	Q8IW36
TGIKPYKCNECGKMF	ZNF578	366	Q96N58
MVEKPYKCGVCGKSF	ZSCAN2	441	Q7Z7L9
KPYKCNECGKAFIQM	ZNF568	276	Q3ZCX4
FGCIKEVMPIACGNK	STAC	181	Q99469
NEKPFVCKECGMAFR	ZNF780A	301	O75290
FKADDGPCKAIMKRF	TFPI	56	P10646
GELVMCDKKDCPKAY	NSD3	1331	Q9BZ95
KECAKQGKMPCYFDL	SETD2	1461	Q9BYW2
MREKPFKCNECGKSF	ZNF585A	181	Q6P3V2
KPNVCSMCGKAFIKK	ZNF630	261	Q2M218
RCVIMCQGSKKDFFK	SNRNP200	1701	O75643
CQICFVKSGPKLMDF	ZC3H7A	446	Q8IWR0
PGFLNMKIKFVCAQC	ZC3H7A	701	Q8IWR0
NPFKCKECGKSFCML	ZNF708	166	P17019
EMPYKCIECGKAFKR	ZNF550	396	Q7Z398
PCMICGKKFKSRGFL	ZFX	426	P17010
KPYICNECGKGFTMK	ZNF432	371	O94892
QMIHTGEKPFKCKEC	ZNF215	481	Q9UL58
KICMVCGFLFPNKES	ZNF217	216	O75362
FEKKENSPEFKMCGI	SCN11A	301	Q9UI33
KPFECNECGKAFSRM	ZNF12	631	P17014
MQICDKCGKKFVLES	ZNF652	271	Q9Y2D9
EKPFKCQECGKSFQM	ZNF195	241	O14628
NMQKKPSKCSECGKF	ZNF501	16	Q96CX3
GENAYMCAKCKKKVP	USP36	296	Q9P275
EKPFMCKQCEKSFSL	ZNF337	541	Q9Y3M9
KIPSLGMCFCEENKE	UBASH3A	616	P57075
KKPFTCMECGKAFKF	ZNF266	461	Q14584
KKGICPICFKNEMDF	KCNF1	101	Q9H3M0