Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainPTPc_motif

PTPN4 TNS1

6.09e-0359372SM00404
DomainTyr_Pase_cat

PTPN4 TNS1

6.09e-0359372IPR003595
Pubmed

Heterotaxy-spectrum heart defects in Zic3 hypomorphic mice.

ZIC3 TBX5

1.16e-05538223999067
Pubmed

Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons.

LHX2 TBX5

1.76e-041838220503368
Pubmed

Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.

LHX2 TBX5

1.96e-041938220890044
Pubmed

The transcription factor Maz is essential for normal eye development.

LHX2 TBX5

2.41e-042138232571845
Pubmed

Optic vesicle morphogenesis requires primary cilia.

LHX2 TBX5

2.41e-042138232169553
Pubmed

T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.

ZIC3 TBX5

3.43e-042538227046536
Pubmed

Canonical Wnt/β-catenin signalling is essential for optic cup formation.

LHX2 TBX5

4.63e-042938224324671
Pubmed

Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.

LHX2 TBX5

4.63e-042938219906857
Pubmed

Multiple loci are associated with white blood cell phenotypes.

MED24 CERKL

6.01e-043338221738480
Pubmed

Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.

LHX2 TBX5

6.01e-043338224705356
Pubmed

The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

ALPL ZIC3

6.38e-043438220007774
GeneFamilyOlfactory receptors, family 52

OR52N1 OR52E8

1.91e-0349242165
GeneFamilySterile alpha motif domain containing

SAMD9L EPHA1

6.03e-0388242760
GeneFamilySH2 domain containing

TNS1 SH3BP2

7.87e-03101242741
GeneFamilyArmadillo repeat containing|Protein phosphatase 1 regulatory subunits

CASP2 TNS1

2.38e-02181242694
CoexpressionAtlaskidney_adult_GlomCapSys_Tie2_k-means-cluster#1_top-relative-expression-ranked_500

SAMD9L TNS1 ALPL

1.95e-0531363gudmap_kidney_adult_GlomCapSys_Tie2_k1_500
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

PEPD EHHADH SH3BP2 AOX1

1.87e-05186384b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PEPD EHHADH SH3BP2 AOX1

1.91e-05187384f1356273bd3587b6883295edf15cb9cdb706c057
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PEPD EHHADH SH3BP2 AOX1

1.91e-05187384dcf6475ece5b34d9d58a0d1f51c18acedb19c119
DrugProtoveratrine A [143-57-7]; Down 200; 5uM; MCF7; HT_HG-U133A

CEP104 LHX2 DMXL2 TMEM62 EPHA1

1.50e-051893852800_DN
Drugthioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

CASP2 MED24 LHX2 TNS1 EHHADH

1.58e-051913854454_DN
Drugthioridazine hydrochloride; Down 200; 10uM; PC3; HT_HG-U133A

CASP2 CEP104 MED24 LHX2 EPHA1

1.66e-051933851230_DN
DrugGramine [87-52-5]; Up 200; 23uM; MCF7; HT_HG-U133A

TNS1 SH3BP2 ZIC3 AOX1 TBX5

1.66e-051933854118_UP
DrugZardaverine [101975-10-4]; Down 200; 15uM; MCF7; HT_HG-U133A

MED24 LHX2 BTD ZNF446 SH3BP2

1.79e-051963854793_DN
DrugSaquinavir mesylate [149845-06-7]; Down 200; 5.2uM; MCF7; HT_HG-U133A

CASP2 EHHADH BTD SH3BP2 EPHA1

1.83e-051973853549_DN
DrugDiazoxide [364-98-7]; Up 200; 17.4uM; MCF7; HT_HG-U133A

CEP104 TNS1 BTD SH3BP2 TBX5

1.88e-051983852214_UP
Drugcis-4,7,10,13,16,19-Docosahexaenoic acid ethyl ester; Down 200; 100uM; MCF7; HT_HG-U133A_EA

CASP2 CEP104 LHX2 BTD AOX1

1.88e-05198385881_DN
Drug2-propylpentanoic acid; Up 200; 50uM; MCF7; HT_HG-U133A

CEP104 ABHD14A TMEM62 BTD AOX1

1.93e-051993856941_UP
Drugvanillic acid

CCDC6 EHHADH AOX1

2.06e-0532383CID000008468
DrugNivalenol hydrate

A1BG HRC EPHA1

3.48e-0538383CID000031829
Drugp-dimethylaminocinnamaldehyde

ALPL AOX1

5.67e-057382CID000092224
Drugtriphenylamine

CCDC6 BTD

7.55e-058382CID000011775
Druglead nitrate

LHX2 EHHADH ALPL

8.96e-0552383CID000024924
DrugAo G

PTPN4 AOX1

1.21e-0410382CID000448297
Drug[(E)-[amino-[ethyl(nitroso)amino]methylidene]amino]-hydroxy-oxoazanium

PEPD PTPN4

1.48e-0411382CID009572846
DrugAC1L1UJE

LHX2 PYROXD2

2.09e-0413382CID000010121
Drugphosphinate

A1BG EPHA1 ZIC3

2.17e-0470383CID000022497
Drugisoxanthopterin

CCDC6 AOX1

2.44e-0414382CID000010729
DrugWithaferin A [5119-48-2]; Down 200; 1uM; PC3; HT_HG-U133A

CASP2 TNS1 EPHA1 TBX5

2.56e-041863843819_DN
Drug5224221; Down 200; 12uM; MCF7; HT_HG-U133A_EA

ABHD14A LHX2 EHHADH AOX1

2.56e-04186384839_DN
DrugMethimazole [60-56-0]; Down 200; 35uM; PC3; HT_HG-U133A

CASP2 TNS1 ZNF446 TBX5

2.83e-041913843815_DN
Drugrottlerin; Down 200; 10uM; MCF7; HT_HG-U133A_EA

CASP2 LHX2 MLXIP BTD

2.83e-04191384941_DN
DrugProguanil hydrochloride [637-32-1]; Down 200; 13.8uM; MCF7; HT_HG-U133A

ABHD14A BTD SH3BP2 EPHA1

2.89e-041923843505_DN
DrugEnilconazole [35554-44-0]; Down 200; 13.4uM; HL60; HT_HG-U133A

CEP104 ABHD14A TNS1 SH3BP2

2.95e-041933843139_DN
Drugradicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A

LHX2 MLXIP EPHA1 AOX1

2.95e-041933841644_DN
Drugpararosaniline base; Down 200; 10uM; MCF7; HT_HG-U133A_EA

CASP2 LHX2 BTD EPHA1

2.95e-04193384893_DN
DrugAcenocoumarol [152-72-7]; Down 200; 11.4uM; MCF7; HT_HG-U133A

ABHD14A BICRAL BTD SH3BP2

2.95e-041933847232_DN
DrugPHA-00745360 [351320-33-7]; Down 200; 1uM; MCF7; HT_HG-U133A

CASP2 LHX2 SH3BP2 TBX5

3.01e-041943843910_DN
DrugGraveoline [485-61-0]; Down 200; 14.4uM; MCF7; HT_HG-U133A

CASP2 TNS1 BTD EPHA1

3.01e-041943844738_DN
DrugKarakoline [39089-30-0]; Down 200; 10.6uM; MCF7; HT_HG-U133A

LHX2 DMXL2 TNS1 EPHA1

3.01e-041943844763_DN
DrugEtifenin [63245-28-3]; Up 200; 12.4uM; MCF7; HT_HG-U133A

LHX2 SH3BP2 EPHA1 TBX5

3.01e-041943844117_UP
DrugRapamycin; Down 200; 0.1uM; PC3; HT_HG-U133A

CASP2 LHX2 MLXIP TNS1

3.07e-041953844466_DN
DrugButylparaben [94-26-8]; Up 200; 20.6uM; MCF7; HT_HG-U133A

CEP104 LHX2 MLXIP ZNF446

3.07e-041953845608_UP
DrugHydrastinine hydrochloride [4884-68-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A

CASP2 LHX2 MLXIP SH3BP2

3.07e-041953842283_DN
DrugChicago sky blue 6B [2610-05-1]; Up 200; 4uM; MCF7; HT_HG-U133A

CASP2 MLXIP BTD SH3BP2

3.07e-041953843266_UP
DrugHydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; MCF7; HT_HG-U133A

EHHADH BTD EPHA1 AOX1

3.07e-041953842311_DN
DrugBetahistine mesylate [54856-23-4]; Up 200; 17.2uM; MCF7; HT_HG-U133A

MLXIP TNS1 SH3BP2 TBX5

3.07e-041953842833_UP
DrugPhenindione [83-12-5]; Up 200; 18uM; MCF7; HT_HG-U133A

TNS1 ZNF446 SH3BP2 TBX5

3.07e-041953842868_UP
DrugSulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; MCF7; HT_HG-U133A

CASP2 TMEM62 ZNF446 SH3BP2

3.13e-041963847200_UP
DrugGemfibrozil [25812-30-0]; Up 200; 16uM; MCF7; HT_HG-U133A

CEP104 TNS1 BTD SH3BP2

3.13e-041963845488_UP
DrugAcacetin [480-44-4]; Up 200; 14uM; PC3; HT_HG-U133A

CASP2 DMXL2 MLXIP SH3BP2

3.13e-041963844324_UP
DrugTriamterene [396-01-0]; Up 200; 15.8uM; MCF7; HT_HG-U133A

EHHADH BTD SH3BP2 AOX1

3.13e-041963841697_UP
DrugEtilefrine hydrochloride [534-87-2]; Up 200; 18.4uM; MCF7; HT_HG-U133A

CASP2 TNS1 SH3BP2 TBX5

3.13e-041963844415_UP
DrugPhentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; MCF7; HT_HG-U133A

CASP2 ZNF446 EPHA1 TBX5

3.13e-041963843971_DN
DrugPantothenic acid calcium salt monohydrate [63409-48-3]; Down 200; 8uM; MCF7; HT_HG-U133A

BTD ZNF446 SH3BP2 AOX1

3.13e-041963844775_DN
DrugSpiramycin [8025-81-8]; Up 200; 4.8uM; PC3; HT_HG-U133A

MLXIP CCDC6 BTD EPHA1

3.13e-041963844319_UP
DrugRifampicin [13292-46-1]; Up 200; 4.8uM; MCF7; HT_HG-U133A

CASP2 LHX2 DMXL2 TBX5

3.13e-041963842847_UP
DrugChelidonine monohydrate (+) [476-32-4]; Down 200; 10.8uM; MCF7; HT_HG-U133A

CASP2 MED24 LHX2 EPHA1

3.13e-041963846236_DN
DrugPropylthiouracil [51-52-5]; Up 200; 23.4uM; MCF7; HT_HG-U133A

CASP2 DMXL2 MLXIP ZNF446

3.13e-041963842837_UP
DrugMolsidomine [25717-80-0]; Up 200; 16.6uM; MCF7; HT_HG-U133A

MLXIP ZNF446 SH3BP2 TBX5

3.13e-041963842862_UP
DrugLoracarbef [121961-22-6]; Down 200; 10.8uM; PC3; HT_HG-U133A

TNS1 BTD SH3BP2 EPHA1

3.13e-041963845073_DN
DrugTimolol maleate salt [26921-17-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A

TMEM62 BTD ZNF446 EPHA1

3.13e-041963846483_DN
DrugHeliotrine [303-33-3]; Down 200; 12.8uM; MCF7; HT_HG-U133A

CASP2 LHX2 SH3BP2 EPHA1

3.13e-041963844739_DN
DrugTranexamic acid [1197-18-8]; Down 200; 25.4uM; MCF7; HT_HG-U133A

ABHD14A TMEM62 BTD EPHA1

3.13e-041963846238_DN
Drug5186223; Down 200; 12uM; MCF7; HT_HG-U133A_EA

CEP104 ABHD14A LHX2 SH3BP2

3.19e-04197384885_DN
DrugOleandomycin phosphate [7060-74-4]; Down 200; 5uM; MCF7; HT_HG-U133A

CASP2 SH3BP2 EPHA1 AOX1

3.19e-041973841518_DN
DrugBenfotiamine [22457-89-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A

ABHD14A MLXIP TNS1 SH3BP2

3.19e-041973843837_DN
DrugCP-320650-01 [172079-28-6]; Down 200; 1uM; PC3; HT_HG-U133A

MLXIP ZNF446 SH3BP2 TBX5

3.19e-041973843825_DN
DrugBethanechol chloride [590-63-6]; Down 200; 20.4uM; HL60; HT_HG-U133A

PEPD CEP104 BTD SH3BP2

3.19e-041973842975_DN
DrugPirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A

CASP2 MLXIP SH3BP2 ZIC3

3.19e-041973845274_DN
DrugPiperidolate hydrochloride [129-77-1]; Up 200; 11.2uM; MCF7; HT_HG-U133A

CASP2 BTD SH3BP2 ZIC3

3.19e-041973843551_UP
DrugIsosorbide dinitrate [87-33-2]; Up 200; 17uM; MCF7; HT_HG-U133A

CASP2 TNS1 ZIC3 TBX5

3.19e-041973844742_UP
Drugcopper(II) sulfate pentahydrate; Down 200; 100uM; MCF7; HG-U133A

CEP104 LHX2 TNS1 TBX5

3.19e-04197384438_DN
DrugTriflusal [322-79-2]; Down 200; 16.2uM; HL60; HG-U133A

CASP2 PTPN4 MLXIP SH3BP2

3.19e-041973841717_DN
DrugCGX 0596987; Up 200; 20uM; MCF7; HT_HG-U133A

CASP2 TNS1 SH3BP2 ALPL

3.19e-041973846412_UP
DrugEthionamide [536-33-4]; Up 200; 24uM; MCF7; HT_HG-U133A

CASP2 TNS1 SH3BP2 TBX5

3.19e-041973844418_UP
DrugBrompheniramine maleate [980-71-2]; Up 200; 9.2uM; MCF7; HT_HG-U133A

DMXL2 SH3BP2 AOX1 TBX5

3.19e-041973844131_UP
DrugConessine [546-06-5]; Down 200; 11.2uM; MCF7; HT_HG-U133A

CEP104 ABHD14A BTD SH3BP2

3.19e-041973844777_DN
DrugDilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT_HG-U133A

LHX2 MLXIP TNS1 ALPL

3.25e-041983842294_UP
DrugGossypol [303-45-7]; Down 200; 7.8uM; MCF7; HT_HG-U133A

CASP2 LHX2 DMXL2 EPHA1

3.25e-041983844762_DN
Drugiloprost; Down 200; 1uM; SKMEL5; HG-U133A

MLXIP TNS1 EPHA1 ZNF184

3.25e-04198384496_DN
DrugCholecalciferol [67-97-0]; Up 200; 10.4uM; PC3; HT_HG-U133A

CASP2 ZNF446 SH3BP2 TBX5

3.25e-041983846656_UP
DrugPNU-0230031 [267429-39-0]; Down 200; 1uM; MCF7; HT_HG-U133A

LHX2 BTD SH3BP2 TBX5

3.25e-041983843632_DN
Drugnordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A

TMEM62 SH3BP2 EPHA1 TBX5

3.25e-041983845583_DN
DrugAntipyrine [60-80-0]; Up 200; 21.2uM; MCF7; HT_HG-U133A

CEP104 MLXIP ZNF446 SH3BP2

3.25e-041983841489_UP
DrugW-13, hydrochloride; Down 200; 10uM; MCF7; HG-U133A

LHX2 TNS1 BTD TBX5

3.25e-04198384440_DN
DrugNifedipine [21829-25-4]; Down 200; 11.6uM; PC3; HT_HG-U133A

MED24 TMEM62 TNS1 BTD

3.25e-041983847303_DN
DrugLY 294002; Up 200; 0.1uM; MCF7; HT_HG-U133A

CASP2 ABHD14A LHX2 BTD

3.25e-041983846935_UP
DrugTribenoside [10310-32-4]; Up 200; 8.4uM; MCF7; HT_HG-U133A

CCDC6 TNS1 SH3BP2 EPHA1

3.25e-041983845429_UP
DrugChlorpropamide [94-20-2]; Down 200; 14.4uM; MCF7; HT_HG-U133A

CASP2 SH3BP2 EPHA1 AOX1

3.25e-041983845391_DN
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; MCF7; HT_HG-U133A

CASP2 CEP104 TMEM62 SH3BP2

3.31e-041993845003_DN
DrugIsocarboxazid [59-63-2]; Down 200; 17.2uM; HL60; HT_HG-U133A

PTPN4 DMXL2 BTD SH3BP2

3.31e-041993842562_DN
DrugEucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; HL60; HT_HG-U133A

CASP2 CEP104 DMXL2 BICRAL

3.31e-041993842556_DN
DrugDihydroergocristine mesylate [24730-10-7]; Up 200; 5.6uM; PC3; HT_HG-U133A

CASP2 LHX2 BTD EPHA1

3.31e-041993847275_UP
DrugTTNPB; Down 200; 0.1uM; MCF7; HG-U133A

LHX2 MLXIP TNS1 ZNF446

3.31e-04199384223_DN
DrugPHA-00851261E [724719-49-7]; Up 200; 1uM; PC3; HT_HG-U133A

CASP2 TNS1 SH3BP2 ALPL

3.38e-042003843776_UP
DrugVitexin [3681-93-4]; Down 200; 9.2uM; MCF7; HT_HG-U133A

DMXL2 BICRAL MLXIP AOX1

3.38e-042003844413_DN
DrugKetotifen fumarate [34580-14-8]; Down 200; 9.4uM; PC3; HT_HG-U133A

CASP2 TMEM62 ZNF446 SH3BP2

3.38e-042003845842_DN
Drugss,ss-carotene

PEPD CCDC6 ALPL PYROXD2

3.44e-04201384CID000000573
Drugisovanillin

LHX2 AOX1

4.08e-0418382CID000012127
DrugHlnl

PEPD LHX2

4.56e-0419382CID000122155
Diseasevitamin B6 measurement

ALPL PYROXD2

6.47e-0510362EFO_0004621
DiseaseQRS amplitude, QRS complex

ZNF184 TBX5

1.71e-0350362EFO_0005054, EFO_0007742
DiseaseHepatomegaly

PEPD A1BG

1.99e-0354362C0019209

Protein segments in the cluster

PeptideGeneStartEntry
GHLHTLGGLMPVLHT

TMEM62

256

Q0P6H9
GVHSPLMKAQFITHH

nan

16

Q6ZRP5
IMGQFSHPHILHLEG

EPHA1

676

P21709
VGSMVEHYHTHVLPS

SH3BP2

531

P78314
PGLHVQHMGTSHGIT

CCDC6

396

Q16204
HTLLHQEGMSVGSPH

DMXL2

576

Q8TDJ6
GHPIMHLSGVKHATG

AOX1

581

Q06278
QAHLGAVFMPHGLGH

PEPD

356

P12955
HVRCLLTPGHTAGHM

HAGHL

101

Q6PII5
GGSHHKVSVSPVVHV

HNRNPLL

66

Q8WVV9
LRPSSVGHLVDHMVH

PTPN4

411

P29074
VLMHHGESSQVLHPG

A1BG

211

P04217
LMRGHHQLHGFVPIA

ABHD14A

181

Q9BUJ0
VLHHMVKISGGPHIS

MAGEA3

286

P43357
FGHTVLVGSHIVPHM

FER1L4

1016

A9Z1Z3
EIPFKFHMLHSGLVH

CARM1

371

Q86X55
HLVIGTHFFSPAHVM

EHHADH

426

Q08426
MLFHSLSGPEVHGVI

LHX2

1

P50458
VFSKGPMAHLLHGVH

ALPL

461

P05186
IIHSGHFMVSSPHRE

MLXIP

76

Q9HAP2
MPHKIGFVVVSSSGH

CEP104

1

O60308
HGFMQHVGISVPSQH

BICRAL

186

Q6AI39
VHHPVLGMTGSGIHT

BTD

301

P43251
GVPHVITATLHIIMG

CERKL

311

Q49MI3
VMVHGRNHTPFLGHH

SCNN1D

491

P51172
ILGVCGMHPHHQETL

CASP2

26

P42575
GHRIIPHTYCEHMGI

OR52E8

176

Q6IFG1
FGGHTIPLHIHIIMA

OR52N1

266

Q8NH53
TLSPHQYHSVHGVGM

TBX5

496

Q99593
HHPGCGGTTLAMHVL

SAMD9L

741

Q8IVG5
TIGLTGIHLHTHYVM

PKDREJ

1146

Q9NTG1
VHAEQMHKTGFPTVH

MED24

231

O75448
GSIKEMSHHPPGHTV

HRC

456

P23327
IESGRMTHHHPTGYL

ADPRH

156

P54922
HELVTHVTMEHVGGP

ZIC3

276

O60481
PHTPGSGYVLLHHVM

PYROXD2

256

Q8N2H3
LHHVIMHGIPNFESK

TNS1

186

Q9HBL0
VFVIHHRTHTSGPGV

ZNF446

346

Q9NWS9
GPSTFIRHHMIHTGE

ZNF184

401

Q99676