Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainF_ACTIN_CAPPING_A_1

CAPZA1 CAPZA2

9.90e-0531082PS00748
DomainF_ACTIN_CAPPING_A_2

CAPZA1 CAPZA2

9.90e-0531082PS00749
DomainF-actin_cap_A

CAPZA1 CAPZA2

9.90e-0531082PF01267
DomainCapZ_alpha

CAPZA1 CAPZA2

9.90e-0531082IPR002189
DomainF-actin_cap_asu_CS

CAPZA1 CAPZA2

9.90e-0531082IPR017865
DomainBcl2-/adenovirus-E1B

PRUNE2 BNIP2

1.97e-0441082IPR022181
DomainBNIP2

PRUNE2 BNIP2

1.97e-0441082PF12496
DomainCRAL_TRIO

PRUNE2 BNIP2 SEC14L1

2.32e-04211083PF00650
Domain-

PRUNE2 BNIP2 SEC14L1

3.06e-042310833.40.525.10
DomainAnaphylatoxin_comp_syst

C4A C4B

3.28e-0451082IPR018081
DomainAnaphylatoxn_comp_syst_dom

C4A C4B

3.28e-0451082IPR001840
DomainSEC14

PRUNE2 BNIP2 SEC14L1

3.94e-04251083SM00516
DomainCRAL_TRIO

PRUNE2 BNIP2 SEC14L1

4.97e-04271083PS50191
DomainCRAL-TRIO_dom

PRUNE2 BNIP2 SEC14L1

5.54e-04281083IPR001251
DomainUSP_CS

CYLD USP43 USP2 USP51

5.78e-04661084IPR018200
DomainANATO

C4A C4B

6.83e-0471082SM00104
DomainANAPHYLATOXIN_2

C4A C4B

6.83e-0471082PS01178
DomainANAPHYLATOXIN_1

C4A C4B

6.83e-0471082PS01177
DomainANATO

C4A C4B

6.83e-0471082PF01821
DomainAnaphylatoxin/fibulin

C4A C4B

6.83e-0471082IPR000020
DomainUSP_1

CYLD USP43 USP2 USP51

7.23e-04701084PS00972
DomainRA

MYO9A MYO9B RGL3

7.51e-04311083SM00314
DomainUCH

CYLD USP43 USP2 USP51

7.63e-04711084PF00443
DomainUSP_2

CYLD USP43 USP2 USP51

7.63e-04711084PS00973
DomainUSP_3

CYLD USP43 USP2 USP51

8.04e-04721084PS50235
DomainUSP_dom

CYLD USP43 USP2 USP51

8.04e-04721084IPR028889
DomainPeptidase_C19_UCH

CYLD USP43 USP2 USP51

8.04e-04721084IPR001394
DomainMacrogloblnA2_thiol-ester-bond

C4A C4B

9.07e-0481082IPR019565
DomainThiol-ester_cl

C4A C4B

9.07e-0481082PF10569
DomainMacrogloblnA2_CS

C4A C4B

9.07e-0481082IPR019742
DomainRA

MYO9A MYO9B RGL3

1.17e-03361083PF00788
DomainP-loop_NTPase

MYO7A MYO9A MYO9B CFTR ABCC6 LONP1 CIITA ABCE1 DGUOK RECQL4 HS3ST3A1 DNAH8 NLRP8

1.22e-0384810813IPR027417
DomainRA

MYO9A MYO9B RGL3

1.27e-03371083PS50200
DomainMyosin_head_motor_dom

MYO7A MYO9A MYO9B

1.37e-03381083IPR001609
DomainMYOSIN_MOTOR

MYO7A MYO9A MYO9B

1.37e-03381083PS51456
DomainMyosin_head

MYO7A MYO9A MYO9B

1.37e-03381083PF00063
DomainMYSc

MYO7A MYO9A MYO9B

1.37e-03381083SM00242
DomainA2M

C4A C4B

1.45e-03101082PF00207
DomainA2M_N_2

C4A C4B

1.45e-03101082IPR011625
DomainA2M_comp

C4A C4B

1.45e-03101082IPR011626
DomainA2M_recep

C4A C4B

1.45e-03101082PF07677
DomainA2M_comp

C4A C4B

1.45e-03101082PF07678
DomainA2M_N

C4A C4B

1.45e-03101082PF01835
DomainA2M_N

C4A C4B

1.45e-03101082IPR002890
DomainA-macroglobulin_rcpt-bd

C4A C4B

1.45e-03101082IPR009048
DomainALPHA_2_MACROGLOBULIN

C4A C4B

1.45e-03101082PS00477
DomainA2M_N_2

C4A C4B

1.45e-03101082PF07703
DomainMacroglobln_a2

C4A C4B

1.45e-03101082IPR001599
DomainAAA

CFTR ABCC6 LONP1 ABCE1 DNAH8

1.50e-031441085SM00382
DomainAAA+_ATPase

CFTR ABCC6 LONP1 ABCE1 DNAH8

1.50e-031441085IPR003593
DomainRA_dom

MYO9A MYO9B RGL3

1.59e-03401083IPR000159
DomainABC_transporter_CS

CFTR ABCC6 ABCE1

1.83e-03421083IPR017871
DomainTRYPSIN_SER

CTRB2 TMPRSS5 OVCH1 CTRB1

1.84e-03901084IPR033116
Domain-

MYO7A FRMPD2 DOCK10 SYNGAP1 OSBPL5 NGEF PLCG2 CYTH4

1.96e-0339110882.30.29.30
DomainCRAL_TRIO_2

PRUNE2 BNIP2

2.11e-03121082PF13716
DomainPH

DOCK10 SYNGAP1 OSBPL5 NGEF PLCG2 CYTH4

2.15e-032291086PF00169
Domain-

CAD SYN2

2.48e-031310823.40.50.20
DomainABC_tran

CFTR ABCC6 ABCE1

2.69e-03481083PF00005
DomainABC_TRANSPORTER_2

CFTR ABCC6 ABCE1

2.69e-03481083PS50893
DomainABC_TRANSPORTER_1

CFTR ABCC6 ABCE1

2.86e-03491083PS00211
DomainPreATP-grasp_dom

CAD SYN2

2.88e-03141082IPR016185
DomainTRYPSIN_HIS

CTRB2 TMPRSS5 OVCH1 CTRB1

3.01e-031031084IPR018114
DomainABC_transporter-like

CFTR ABCC6 ABCE1

3.03e-03501083IPR003439
Domain-

CAD SYN2

3.31e-031510823.30.1490.20
DomainPH_dom-like

MYO7A FRMPD2 DOCK10 SYNGAP1 OSBPL5 NGEF PLCG2 CYTH4

3.32e-034261088IPR011993
DomainTRYPSIN_SER

CTRB2 TMPRSS5 OVCH1 CTRB1

3.34e-031061084PS00135
DomainTRYPSIN_HIS

CTRB2 TMPRSS5 OVCH1 CTRB1

3.46e-031071084PS00134
DomainPeptidase_S1A

CTRB2 TMPRSS5 OVCH1 CTRB1

4.20e-031131084IPR001314
DomainGal_mutarotase_SF_dom

MGAM MAN2C1

4.26e-03171082IPR011013
DomainC345C

C4A C4B

4.26e-03171082SM00643
DomainUbiquitin-rel_dom

MYO7A MYO9A MYO9B RGL3 FRMPD2

4.33e-031841085IPR029071
DomainTRYPSIN_DOM

CTRB2 TMPRSS5 OVCH1 CTRB1

4.47e-031151084PS50240
DomainTryp_SPc

CTRB2 TMPRSS5 OVCH1 CTRB1

4.75e-031171084SM00020
DomainATP_grasp_subdomain_1

CAD SYN2

4.77e-03181082IPR013815
DomainTerpenoid_cyclase/PrenylTrfase

C4A C4B

4.77e-03181082IPR008930
Domain-

CAD SYN2

4.77e-031810823.30.470.20
DomainHATPase_c

PMS1 PDK2

4.77e-03181082SM00387
DomainNTR

C4A C4B

5.31e-03191082PF01759
DomainNetrin_module_non-TIMP

C4A C4B

5.31e-03191082IPR018933
DomainHATPase_c

PMS1 PDK2

5.31e-03191082PF02518
DomainTrypsin_dom

CTRB2 TMPRSS5 OVCH1 CTRB1

5.35e-031211084IPR001254
DomainTrypsin

CTRB2 TMPRSS5 OVCH1 CTRB1

5.35e-031211084PF00089
DomainPH

DOCK10 SYNGAP1 OSBPL5 NGEF PLCG2 CYTH4

5.56e-032781086SM00233
DomainPH_DOMAIN

DOCK10 SYNGAP1 OSBPL5 NGEF PLCG2 CYTH4

5.66e-032791086PS50003
DomainPeptidase_S1_PA

CTRB2 TMPRSS5 OVCH1 CTRB1

5.67e-031231084IPR009003
DomainPH_domain

DOCK10 SYNGAP1 OSBPL5 NGEF PLCG2 CYTH4

5.76e-032801086IPR001849
Pubmed

BMP signaling in the human fetal ovary is developmentally regulated and promotes primordial germ cell apoptosis.

MSX1 MSX2 BMP2

1.26e-074111320506112
Pubmed

Changes in homeobox-containing gene expression during ectopic bone formation induced by bone morphogenetic protein.

MSX1 MSX2 BMP2

1.26e-07411137911662
Pubmed

Comparison of expression of the msx-1, msx-2, BMP-2 and BMP-4 genes in the mouse upper diastemal and molar tooth primordia.

MSX1 MSX2 BMP2

1.26e-07411137577436
Pubmed

Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.

PMS1 ACOT9 PKP4 DOCK10 UPF2 ABCE1 RECQL4 RBM14 XRN1 DIAPH2 C4A C4B SLC33A1

1.69e-076501111338777146
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

CAD MYO9A MYO9B PKP4 UBR4 CAPZA1 CAPZA2 DOCK10 GTF3C5 LONP1 UPF2 ABCE1 RECQL4 RBM14 XRN1 PRKDC PLCG2 NIPBL

2.87e-0713531111829467282
Pubmed

Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development.

MSX1 MSX2 BMP2

6.28e-07611138104708
Pubmed

Regulation of Msx-1, Msx-2, Bmp-2 and Bmp-4 during foetal and postnatal mammary gland development.

MSX1 MSX2 BMP2

6.28e-07611138787747
Pubmed

Msx2 -/- transgenic mice develop compound amelogenesis imperfecta, dentinogenesis imperfecta and periodental osteopetrosis.

MSX1 MSX2 BMP2

6.28e-076111317878071
Pubmed

Tails of unconventional myosins.

MYO7A MYO9A MYO9B

1.10e-067111311212352
Pubmed

Molecular mechanisms of cell and tissue interactions during early tooth development.

MSX1 MSX2 BMP2

1.10e-06711138769660
Pubmed

Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents.

MSX1 MSX2 BMP2

1.75e-06811139799429
Pubmed

CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.

CYLD MGAM CAD UBR4 CAPZA1 CAPZA2 KLHL13

2.06e-06182111731067453
Pubmed

FGF-, BMP- and Shh-mediated signalling pathways in the regulation of cranial suture morphogenesis and calvarial bone development.

MSX1 MSX2 BMP2

2.62e-06911139477322
Pubmed

Inactivation of Msx1 and Msx2 in neural crest reveals an unexpected role in suppressing heterotopic bone formation in the head.

MSX1 MSX2 BMP2

2.62e-069111320398647
Pubmed

Bmp2, Bmp4 and Bmp7 are co-required in the mouse AER for normal digit patterning but not limb outgrowth.

MSX1 MSX2 BMP2

2.62e-069111322662233
Pubmed

BMP-mediated functional cooperation between Dlx5;Dlx6 and Msx1;Msx2 during mammalian limb development.

MSX1 MSX2 BMP2

2.62e-069111323382810
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CAD MYO7A MYO9A PKP4 CAPZA1 CAPZA2 SYNGAP1 LONP1 UPF2 STON2 NGEF RBM14 XRN1 SYN2 C4A C4B SSH2

2.96e-0614311111737142655
Pubmed

Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.

CAD RGS7BP MYO9A MYO9B PKP4 UBR4 CAPZA1 CAPZA2 ABCE1 RBM14 C4A C4B PRKDC

3.11e-068441111325963833
Pubmed

Hundreds of variants clustered in genomic loci and biological pathways affect human height.

MYO9A MYO9B GHSR BMP2 SOCS5 FGFR4 L3MBTL3

3.59e-06198111720881960
Pubmed

Coordinate regulation and synergistic actions of BMP4, SHH and FGF8 in the rostral prosencephalon regulate morphogenesis of the telencephalic and optic vesicles.

MSX1 MSX2 BMP2

3.74e-0610111311955708
Pubmed

Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.

CYLD PARP11 USP43 USP2

3.74e-0633111430323974
Pubmed

BMP signals control limb bud interdigital programmed cell death by regulating FGF signaling.

MSX1 MSX2 BMP2

5.12e-0611111317537800
Pubmed

Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4.

MSX1 MSX2 BMP2

5.12e-0611111314512019
Pubmed

Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development.

MSX1 MSX2 BMP2

6.82e-0612111322387309
Pubmed

Analysis of Msx1; Msx2 double mutants reveals multiple roles for Msx genes in limb development.

MSX1 MSX2 BMP2

8.84e-0613111315930102
Pubmed

Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice.

EPO CTRB2 SLC9A2 CTRB1

9.08e-0641111423676500
Pubmed

Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.

C4A C4B

1.01e-052111222737222
Pubmed

Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.

C4A C4B

1.01e-052111216565498
Pubmed

Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.

C4A C4B

1.01e-052111215998580
Pubmed

Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene.

MSX1 MSX2

1.01e-05211129256350
Pubmed

High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.

C4A C4B

1.01e-052111219062096
Pubmed

Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands.

CFTR CLCN2

1.01e-052111218801913
Pubmed

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.

C4A C4B

1.01e-052111219933335
Pubmed

Msx1 and Msx2 gene expression is downregulated in the cadmium-induced omphalocele in the chick model.

MSX1 MSX2

1.01e-052111220620318
Pubmed

Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.

C4A C4B

1.01e-05211122459207
Pubmed

Antigen-induced B cell apoptosis is independent of complement C4.

C4A C4B

1.01e-052111217645767
Pubmed

Anti-DNA autoreactivity in C4-deficient mice.

C4A C4B

1.01e-052111212207352
Pubmed

MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo.

CIITA PRKDC

1.01e-052111216081800
Pubmed

The CTRB1-CTRB2 risk allele for chronic pancreatitis discovered in European populations does not contribute to disease risk variation in the Chinese population due to near allele fixation.

CTRB2 CTRB1

1.01e-052111228951524
Pubmed

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

CTRB2 CTRB1

1.01e-052111228754779
Pubmed

Ventral abdominal wall dysmorphogenesis of Msx1/Msx2 double-mutant mice.

MSX1 MSX2

1.01e-052111215803476
Pubmed

Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.

C4A C4B

1.01e-052111227758680
Pubmed

Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.

C4A C4B

1.01e-052111222387014
Pubmed

Cloning of ClC-2 chloride channel from murine duodenum and its presence in CFTR knockout mice.

CFTR CLCN2

1.01e-052111210524221
Pubmed

MHC class II-restricted interaction between thymocytes plays an essential role in the production of innate CD8+ T cells.

CD1D CIITA

1.01e-052111221478404
Pubmed

Tracking a CAD-ALK gene rearrangement in urine and blood of a colorectal cancer patient treated with an ALK inhibitor.

CAD ALK

1.01e-052111228368455
Pubmed

Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.

C4A C4B

1.01e-052111223749435
Pubmed

Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.

C4A C4B

1.01e-052111223918728
Pubmed

Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.

C4A C4B

1.01e-05211123037333
Pubmed

Ectoderm-mesenchyme and mesenchyme-mesenchyme interactions regulate Msx-1 expression and cellular differentiation in the murine limb bud.

MSX1 MSX2

1.01e-05211127537232
Pubmed

Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.

C4A C4B

1.01e-052111211726230
Pubmed

Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.

C4A C4B

1.01e-05211124216347
Pubmed

Sequence determination of the thiolester site of the fourth component of human complement.

C4A C4B

1.01e-05211126950384
Pubmed

Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.

C4A C4B

1.01e-05211128660986
Pubmed

Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.

C4A C4B

1.01e-05211128428773
Pubmed

Comparison of MSX-1 and MSX-2 suggests a molecular basis for functional redundancy.

MSX1 MSX2

1.01e-05211128861098
Pubmed

Regulated expression of homeobox genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions.

MSX1 MSX2

1.01e-05211128660900
Pubmed

Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.

C4A C4B

1.01e-052111224638111
Pubmed

MHC class II-expressing thymocytes suppress invariant NKT cell development.

CD1D CIITA

1.01e-052111218982019
Pubmed

Transcriptional repression of C4 complement by hepatitis C virus proteins.

C4A C4B

1.01e-052111221345967
Pubmed

Cleavage of BNIP-2 and BNIP-XL by caspases.

PRUNE2 BNIP2

1.01e-052111217961507
Pubmed

Additional disruption of the ClC-2 Cl(-) channel does not exacerbate the cystic fibrosis phenotype of cystic fibrosis transmembrane conductance regulator mouse models.

CFTR CLCN2

1.01e-052111215007059
Pubmed

Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.

C4A C4B

1.01e-05211122572548
Pubmed

The complement component C4 of mammals.

C4A C4B

1.01e-05211122302180
Pubmed

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

C4A C4B

1.01e-052111222151770
Pubmed

C4d-positive chronic rejection: a frequent entity with a poor outcome.

C4A C4B

1.01e-052111218091514
Pubmed

Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity.

C4A C4B

1.01e-052111229080553
Pubmed

Molecular cloning and nucleotide sequence of human pancreatic prechymotrypsinogen cDNA.

CTRB2 CTRB1

1.01e-05211122917002
Pubmed

Genes for murine fourth complement component (C4) and sex-limited protein (Slp) identified by hybridization to C4- and Slp-specific cDNA.

C4A C4B

1.01e-05211126589636
Pubmed

Epithelial-mesenchymal interactions are required for msx 1 and msx 2 gene expression in the developing murine molar tooth.

MSX1 MSX2

1.01e-05211128101167
Pubmed

C4 Deficiency is a predisposing factor for Streptococcus pneumoniae-induced autoantibody production.

C4A C4B

1.01e-052111225339671
Pubmed

A study of association of the complement C4 mutations with systemic lupus erythematosus in the Malaysian population.

C4A C4B

1.01e-052111217728371
Pubmed

Genomic cloning and partial characterization of human chymotrypsinogen gene.

CTRB2 CTRB1

1.01e-05211128186414
Pubmed

Structure and organization of the C4 genes.

C4A C4B

1.01e-05211126149580
Pubmed

Sequence heterogeneity of murine complementary DNA clones related to the C4 and C4-Slp isoforms of the fourth complement component.

C4A C4B

1.01e-05211126149581
Pubmed

The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

C4A C4B

1.01e-052111212115608
Pubmed

Biochemistry and biology of anaphylatoxins.

C4A C4B

1.01e-05211123542363
Pubmed

Msx homeobox gene family and craniofacial development.

MSX1 MSX2

1.01e-052111214728799
Pubmed

C4 from C4-high and C4-low mouse strains have identical sequences in the region corresponding to the isotype-specific segment of human C4.

C4A C4B

1.01e-05211122387317
Pubmed

Identification of the size and antigenic determinants of the human C4 gene by a polymerase chain-reaction-based amplification method.

C4A C4B

1.01e-052111216908004
Pubmed

Structural studies on the murine fourth component of complement (C4). IV. Demonstration that C4 and Slp are encoded by separate loci.

C4A C4B

1.01e-05211127365238
Pubmed

Interaction between the labile binding sites of the fourth (C4) and fifth (C5) human complement proteins and erythrocyte cell membranes.

C4A C4B

1.01e-05211127391573
Pubmed

Peritubular capillary C4d deposition in lupus nephritis different from antibody-mediated renal rejection.

C4A C4B

1.01e-052111217971360
Pubmed

Clinical features of patients with homozygous complement C4A or C4B deficiency.

C4A C4B

1.01e-052111229928053
Pubmed

Analysis of C4 and the C4 binding protein in the MRL/lpr mouse.

C4A C4B

1.01e-052111217971229
Pubmed

Msh homeobox 1 (Msx1)- and Msx2-overexpressing bone marrow-derived mesenchymal stem cells resemble blastema cells and enhance regeneration in mice.

MSX1 MSX2

1.01e-052111228461333
Pubmed

Genetic deficiency of C4 presenting with recurrent infections and a SLE-like disease. Genetic and immunologic studies.

C4A C4B

1.01e-05211126881182
Pubmed

[Induction phenomena during vertebrate limb development and homeo box gene expression].

MSX1 MSX2

1.01e-05211128099267
Pubmed

Partial C4 deficiency in juvenile idiopathic arthritis patients.

C4A C4B

1.01e-052111217921792
Pubmed

Complement activation and complement receptors on follicular dendritic cells are critical for the function of a targeted adjuvant.

C4A C4B

1.01e-052111221880985
Pubmed

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4.

C4A C4B

1.01e-05211126978711
Pubmed

Plasma Complement 3 and Complement 4 Are Promising Biomarkers for Distinguishing NMOSD From MOGAD and Are Associated With the Blood-Brain-Barrier Disruption in NMOSD.

C4A C4B

1.01e-052111235898513
Pubmed

Lubiprostone activates non-CFTR-dependent respiratory epithelial chloride secretion in cystic fibrosis mice.

CFTR CLCN2

1.01e-052111218805957
Pubmed

Borrelia burgdorferi outer surface protein C (OspC) binds complement component C4b and confers bloodstream survival.

C4A C4B

1.01e-052111228873507
Pubmed

Generation of an Msx2-GFP conditional null allele.

MSX1 MSX2

1.01e-052111218442049
Pubmed

Studies on the murine Ss protein: demonstration that the Ss protein is functionally the fourth component of complement.

C4A C4B

1.01e-0521112276882
Pubmed

Amino acid sequence of a polymorphic segment from fragment C4d of human complement component C4.

C4A C4B

1.01e-05211126832377
Pubmed

Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.

C4A C4B

1.01e-05211123794341
Pubmed

Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice.

MSX1 MSX2

1.01e-052111231221479
Pubmed

Position-dependent expression of two related homeobox genes in developing vertebrate limbs.

MSX1 MSX2

1.01e-05211121677742
InteractionVIM interactions

CYLD CAD CFTR UBR4 DOCK10 CC2D1A SYNGAP1 KIAA1671 MSX2 PNMA5 CLCN2 ABCE1 RECQL4 PRKDC ALK FAM118B

5.84e-0680410816int:VIM
GeneFamilyMyosins, class IX

MYO9A MYO9B

1.93e-0528021103
GeneFamilyUbiquitin specific peptidases

CYLD USP43 USP2 USP51

1.10e-0456804366
GeneFamilyRho GTPase activating proteins|BCH domain containing

PRUNE2 BNIP2

4.00e-0478021299
GeneFamilyC3 and PZP like, alpha-2-macroglobulin domain containing

C4A C4B

6.82e-0498021234
GeneFamilyATP binding cassette subfamily C

CFTR ABCC6

1.46e-0313802807
GeneFamilyOlfactory receptors, family 13

OR13C6P OR13C7

4.61e-0323802162
GeneFamilyPHD finger proteins|Lysine demethylases

PHF2 KDM7A

5.01e-0324802485
GeneFamilyNLR family

CIITA NLRP8

5.43e-0325802666
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_FOS|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFAP47 FRMPD2 MSX1 MSX2 STON2 DISP3 HS3ST3A1

3.81e-07184110722c18964818fc9c8f18051f836d718937b0d8d12
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-alveolar_fibroblast-alveolar_fibroblast_l1|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

OPN1SW KLHL13 C4B CTRB1 HS3ST3A1

3.31e-0692110584ac97a16920b912a67ea80e71146eddf9dfa92f
ToppCellIonocyte-iono-1|World / Class top

CFTR ABCC6 MSX2 BMP2 SYN2 PLCG2

3.98e-0616911064b68bcb4b5fc3cd2db23cd4edace7444aa2d605c
ToppCellIonocyte|World / Class top

CFTR ABCC6 MSX2 BMP2 SYN2 PLCG2

4.12e-061701106d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L6_LHX6_GLP1R|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFAP47 CTRB2 CD1D KLHL13 STON2 ALK

5.20e-0617711065e0fca9bd5e5ffe6d39f5bcd81f36512f3b0cb1b
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 RGS7BP WDR25 MSX1 BMP2 KLHL13

5.54e-061791106b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFAP47 RGL3 MSX1 MSX2 STON2 HS3ST3A1

7.12e-0618711062b1b2c3792d6c9ab69675ce88842bb589414b530
ToppCellFetal_29-31_weeks-Immune-monocyte-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO9B ACOT9 PPARD CD1D CIITA CYTH4

7.80e-061901106ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9B ARRDC5 DOCK10 CIITA MS4A14 CYTH4

8.03e-061911106baa70781633a3fe5bf987f9d8dff3884f5167e7f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CFAP47 CFTR TMPRSS5 CLCN2 MS4A14

4.03e-051541105ce4b1e878cd88065fbfd2df18caf19703fec37d8
ToppCell367C-Lymphocytic-CD4_T-cell-Treg_cell_2|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

PHEX PROM2 MS4A14 HS3ST3A1 DNAH8

4.03e-0515411059200e2f1783e54cbc5dfc3b485b57c761af74a46
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

CFTR HCN3 KLHL13 DISP3 ALK

4.70e-0515911057f29f9dcf25ffa1822b137c571e9ac16defc6292
ToppCelldroplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 BMP2 CIITA C4A HS3ST3A1

4.98e-051611105f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCelldroplet-Lung-nan-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 BMP2 CIITA C4A HS3ST3A1

4.98e-051611105110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCellfacs-MAT-Fat-3m-Myeloid-macrophage|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 CIITA PLCG2 LTB4R CYTH4

5.44e-051641105b81498c3934e0d52bf0329dc745e02966f9d8613
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Hematologic-fibroblast|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 ZFYVE16 CIITA LTB4R CYTH4

5.93e-051671105f5bffa77061baec0ba87bd688a047595f32534db
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CFAP47 RGL3 MSX1 MSX2 STON2

6.82e-05172110555fba5ce0ead1114e1a76f67ad68432c6bac90e5
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO9A DUSP1 DOCK10 KDM7A SSH2

7.01e-051731105869da6a65d1b9b7529c666ec44e3c8ddec2ea408
ToppCellIonocyte-iono-2|World / Class top

CFTR CPT2 BMP2 SYN2 PLCG2

7.01e-051731105e5ec28ccc5e048fd98de4c876e5c53b866b66228
ToppCellfacs-Brain_Myeloid-Cerebellum-3m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO9A DUSP1 DOCK10 KDM7A SSH2

7.01e-0517311050672bd8a4a9d18af343d01f09253fb3388896c10
ToppCellfacs-Brain_Myeloid-Cerebellum-3m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MYO9A DUSP1 DOCK10 KDM7A SSH2

7.01e-051731105870e091ec30be01a900e1cb8b9ef1880e3b7b50d
ToppCellfacs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK10 CIITA PROM2 LTB4R CYTH4

7.81e-0517711057bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCellhuman_hepatoblastoma-Tumor_cells-T6|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

PRUNE2 PPARD SLC9A2 KDM7A ALK

8.23e-05179110514fc8ccb6b215063d747643f47d780d2b237eb67
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DACT2 ABCC6 CLCN2 C4B FGFR4

9.13e-051831105d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DUSP1 DOCK10 XRN1 DIAPH2 NIPBL

9.61e-0518511057adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARRDC5 DOCK10 CIITA MS4A14 CYTH4

9.86e-051861105e152bdd837366e3e0b8bcfdb4d53f0685f2e803a
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Degenerative_Descending_Thin_Limb_Cell_Type_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 SLC4A7 MYO9A PKP4 USP43

1.01e-041871105c31130fc2f9f882944b2ba366a034a03f051c4b9
ToppCellcritical-Myeloid-Monocyte-derived_Macrophage|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

PARP11 MSX1 CLCN2 XRN1 DISP3

1.01e-04187110572e4aec49ea0c5fe6cee2a1a46369dbc90cd3fad
ToppCellFetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

MYO7A CIITA STON2 MS4A14 CYTH4

1.01e-04187110539b99f46b723f7f3c44880d7fe8642cbad558b8a
ToppCell-Unknown-Endothelial-Myofibroblast| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCDHGB5 MYO9A XRN1 KDM7A SEC14L1

1.04e-0418811056468fa95ad0395395301115286f2d8c0df5d3882
ToppCell-Unknown-Endothelial| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCDHGB5 MYO9A XRN1 KDM7A SEC14L1

1.04e-0418811057a81ac5c79c3eb26639b52d2b9fd5e7ef9798fd6
ToppCell-Unknown| / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCDHGB5 MYO9A XRN1 KDM7A SEC14L1

1.04e-0418811059cb718bfe1358c6fd842f096e228eb0abb9aefc6
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PRUNE2 SLC4A7 MYO9A PKP4 USP43

1.04e-041881105af740fa78542438fdff627ea1f74f4eee43316be
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CFAP47 RGL3 CFTR USP43 ABCC6

1.06e-0418911057659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

MGAM SLC4A7 DUSP1 USP2 SEC14L1

1.06e-041891105a48df46274d51e84ffb40264646de7346104efb9
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9B ARRDC5 CIITA MS4A14 CYTH4

1.09e-041901105788ff9d8888d2dd25b7e1d7e0e5d57751ce86f19
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARRDC5 DOCK10 CIITA MS4A14 CYTH4

1.12e-041911105c72e62cf5b45c04ee5e7719db31f917c4f76b1e4
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Immune-Myeloid|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ARRDC5 DOCK10 CIITA MS4A14 CYTH4

1.17e-041931105f597fefc54327a1ad136e2f66b6e81cc5c761eb7
ToppCellFetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ZFYVE16 MYO9B PPARD CIITA CYTH4

1.20e-0419411053043f6230fa723037c8cf7123f611ae847b39fd4
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ARRDC5 DOCK10 CIITA MS4A14 CYTH4

1.26e-0419611054370473693d2dd4a8c451a4c477eb79baa33ae12
ToppCellChildren_(3_yrs)-Immune-monocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK10 CD1D CIITA KDM7A CYTH4

1.26e-041961105cacd69be72e6167814f7adea7c5fa114f3103bbb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Monocytic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK10 CD1D CIITA MS4A14 CYTH4

1.26e-041961105291c59b609985167c98a40d4e2caeea2fad74941
ToppCellPBMC-Control-cDC_3|Control / Compartment, Disease Groups and Clusters

CYLD ZNF469 CIITA STON2 CYTH4

1.26e-04196110509d197b321ff9f13c0672ea059c850845b0dbbd5
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|COVID-19 / Disease (COVID-19 only), tissue and cell type

MYO9B DOCK10 CIITA MS4A14 CYTH4

1.29e-041971105e42910a653a1b5bd90c090e9665a84871ed2873f
ToppCellCOVID-19-lung-Macrophage_VCANhi_FCN1hi|lung / Disease (COVID-19 only), tissue and cell type

MGAM MYO9B DOCK10 SSH2 CYTH4

1.29e-041971105a0f8a992282a6d64890f5574c7c9741fcb38dadd
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9B DOCK10 CIITA MS4A14 CYTH4

1.29e-041971105d95565652ca318a2298d6918d54ba6367e9560f4
ToppCellCOVID-19-lung-Macrophage_LDB2hi_OSMRhi_YAP1hi|lung / Disease (COVID-19 only), tissue and cell type

MYO9B DOCK10 CIITA MS4A14 CYTH4

1.29e-0419711053896729740d151f0eb845f1961c7b969bfbdd28d
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9B DOCK10 OVCH1 CIITA MS4A14

1.32e-041981105e125eb8aa57c172e5518874da1bd25998292f5e2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9B DOCK10 CIITA MS4A14 CYTH4

1.32e-04198110596883ad8e189a46ed5b7eaafc0543e53682d26ed
ToppCellsevere-HLA-DR+_CD83+_Monocyte|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

DUSP1 CD1D DIAPH2 MS4A14 FGFR4

1.32e-041981105a77f3440d7fb6a50066abc7e9ad59e83798ef13d
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_alveolar-Macro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9B DOCK10 OVCH1 CIITA MS4A14

1.32e-0419811050baeb8e2c199ff10bb5c829c523546af3c9227c1
ToppCellAdult-Immune|Adult / Lineage, Cell type, age group and donor

MYO9B DOCK10 PPARD CIITA CYTH4

1.32e-0419811059bfd7b88aa646eaf5eddb15cf985c7ca910cb35e
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MGAM MYO7A DOCK10 CIITA RECQL4

1.32e-041981105732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

HCN3 KCNB2 KIAA1671 C3orf33 USP51

1.32e-041981105d6812494874be0c14361ac2ac3e418b335bb8f55
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

MYO9B DOCK10 CIITA MS4A14 CYTH4

1.35e-04199110504adf46975aa4194ea40c7480f8a517def5d929c
ToppCellTracheal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ARRDC5 DOCK10 CIITA MS4A14 CYTH4

1.35e-041991105744b63fba33b176ab7dde11646ccb313665505f7
ToppCellParenchymal-NucSeq-Immune_Myeloid|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO9B DOCK10 CIITA MS4A14 CYTH4

1.35e-0419911057ee2805fd9143eba11bf6832267b62189683608b
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

RGS7BP PKP4 DIAPH2 NIPBL SEC14L1

1.38e-042001105dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellMacroglial-Astrocytes-GFAP---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 FRMPD2 MSX1 MSX2 HS3ST3A1

1.38e-04200110588d66550781a3c9102ff7455f5cff6fb072943cd
ToppCellBronchial-NucSeq-Immune_Myeloid-Macrophage_other|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

MYO7A MYO9B CIITA MS4A14 CYTH4

1.38e-04200110578d75d381cb2b9a4c9eb7c32a07b014eaee39195
ToppCellMacroglial-Astrocytes-GFAP-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 FRMPD2 MSX1 MSX2 HS3ST3A1

1.38e-042001105d6a059b0ef763c281c60b1ac76da6079ea822f80
ToppCellMacroglial-Astrocytes-GFAP--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 FRMPD2 MSX1 MSX2 HS3ST3A1

1.38e-04200110516269fa4adb28fc6ed032bbdba8781237dd0d249
ToppCellMacroglial-Astrocytes-GFAP----L1-2|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 FRMPD2 MSX1 MSX2 HS3ST3A1

1.38e-042001105c6f43bbbd5df5f2c19ae385f1a6b6a330abede2f
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PRUNE2 SLC4A7 KLHL13 DIAPH2 HS3ST3A1

1.38e-042001105dcdaec3ca3a3024dc1b8788c417003f84c2bffdc
ToppCellMacroglial-Astrocytes-GFAP|Macroglial / cells hierarchy compared to all cells using T-Statistic

CFAP47 FRMPD2 MSX1 MSX2 HS3ST3A1

1.38e-04200110579634b1086934412ae92f259ab43554ce545008f
DrugH2DIDS

SLC4A7 CFTR CTRB2 SLC9A2 DIAPH2 CTRB1

1.04e-08331096CID000115184
DrugSri 8835

MGAM CTRB2 CTRB1

2.11e-0661093CID000479975
DrugAcPheOEt

CFTR CTRB2 CTRB1

5.87e-0681093CID000094229
Drugisobutyllithium

MGAM ABCE1 SOCS5

1.25e-05101093CID000141200
DrugBOCPheONP

CTRB2 CTRB1

2.27e-0521092CID000111308
DrugMPM-06

CTRB2 CTRB1

2.27e-0521092CID000161546
DrugNSC-374899

CTRB2 CTRB1

2.27e-0521092CID000435726
Drugmethylbenzenebutanoate

CTRB2 CTRB1

2.27e-0521092CID000281254
DrugAsp-Arg-Val-Tyr-Val-His-Pro-Phe-His-Leu

CTRB2 CTRB1

2.27e-0521092CID004418081
Drugc189

CTRB2 CTRB1

2.27e-0521092CID000248048
Drugdansyl-D-arginine methyl ester

CTRB2 CTRB1

2.27e-0521092CID000191369
Drugmethyl 6-phenylhexanoate

CTRB2 CTRB1

2.27e-0521092CID011820300
Drug4,4'-diaminostilbene

CFTR CLCN2

2.27e-0521092CID000092134
Drug5-aminotetrazole

CTRB2 CTRB1

2.27e-0521092CID000020467
Drug2-bromoisobutyric acid

CTRB2 CTRB1

2.27e-0521092CID000074924
Drugp-toluamidine

CTRB2 CTRB1

2.27e-0521092CID000122753
DrugN-acetyl-alpha-azaphenylalanine phenyl ester

CTRB2 CTRB1

2.27e-0521092CID000191275
Drugisobutyl sulfide

CTRB2 CTRB1

2.27e-0521092CID000011607
Drugnaphthol-AS-BI

MGAM MAN2C1 CTRB2 CTRB1

2.91e-05371094CID000071060
DrugFlunisolide [3385-03-3]; Up 200; 9.2uM; PC3; HT_HG-U133A

PRUNE2 PARP11 MYO9B DUSP1 PPARD SLC9A2 FGFR4

3.92e-0519210974303_UP
DrugMetaraminol bitartrate [33402-03-8]; Up 200; 8.6uM; PC3; HT_HG-U133A

DUSP1 HLCS PPARD PHEX BMP2 SYN2 FGFR4

4.33e-0519510973669_UP
DrugMaprotiline hydrochloride [10347-81-6]; Down 200; 12.8uM; MCF7; HT_HG-U133A

PDK2 HLCS WDR25 MSX1 CLCN2 FGFR4 HS3ST3A1

4.47e-0519610975022_DN
DrugTadjakonine [11087-94-8]; Up 200; 7.4uM; HL60; HT_HG-U133A

ZFYVE16 PDK2 CFTR UBR4 HLCS WDR25 DIAPH2

4.77e-0519810972165_UP
DrugHippeastrine hydrobromide [22352-41-6]; Up 200; 10uM; HL60; HT_HG-U133A

HLCS CTRB2 LBP CIITA DIAPH2 SYN2 LTB4R

4.92e-0519910972187_UP
DrugAC1L1GEZ

EPO RGL3 CFTR CTRB2 PHEX ABCE1 CTRB1

5.08e-052001097CID000003653
DrugN-acetylbenzotriazole

CTRB2 CTRB1

6.79e-0531092CID000087784
Drugphotophor

CTRB2 CTRB1

6.79e-0531092CID000014780
Drugdibutyl iodomethaneboronate

CTRB2 CTRB1

6.79e-0531092CID000098591
Drugzinc;dipicolinate

CTRB2 CTRB1

6.79e-0531092CID004309911
Drug2-oxobut-3-ynoate

CTRB2 CTRB1

6.79e-0531092CID000171547
Drugpotassium phosphate

MSX2 BMP2

6.79e-0531092ctd:C013216
DrugAFMeq

CTRB2 CTRB1

6.79e-0531092CID000194069
DrugBz-Cti-otbu

CTRB2 CTRB1

6.79e-0531092CID006452691
Drugn-(2-oxoethyl)benzamide

CTRB2 CTRB1

6.79e-0531092CID000188995
DrugAC1L49DM

CTRB2 CTRB1

6.79e-0531092CID000152933
Drugc140

CTRB2 CTRB1

6.79e-0531092CID002783250
DrugBenzamidomethaneboronic acid

CTRB2 CTRB1

6.79e-0531092CID000127677
Drug2-aminothiophenol

C4A C4B

6.79e-0531092ctd:C005464
Drugphenyl hippurate

CTRB2 CTRB1

6.79e-0531092CID000076323
DrugFK-386

CTRB2 CTRB1

6.79e-0531092CID000135044
DrugFK-375

CTRB2 CTRB1

6.79e-0531092CID000135042
Drugcarbostyril-124

CTRB2 CTRB1

6.79e-0531092CID000088277
DrugN-trifluoroacetyl-4-fluorophenylalanine

CTRB2 CTRB1

6.79e-0531092CID000328214
DrugC18 4

CTRB2 CTRB1

6.79e-0531092CID000077248
Drugtaraxastane

CTRB2 CTRB1

6.79e-0531092CID006429404
DrugPhe-phe-ome

CTRB2 CTRB1

6.79e-0531092CID000151728
Drugphenylethaneboronic acid

CTRB2 CTRB1

6.79e-0531092CID000065389
Drug3-amino-2-pyridone

CTRB2 CTRB1

6.79e-0531092CID000322353
DrugASA-BMPA

CTRB2 CTRB1

6.79e-0531092CID003035649
Drugcalcium carbonate phosphate

MGAM OPN1SW

6.79e-0531092CID006337635
Drugp-nitrophenyl benzoate

CTRB2 CTRB1

6.79e-0531092CID000070396
DrugZ-Phe-OMe

CTRB2 CTRB1

6.79e-0531092CID003082435
Drug3-methylcoumarin

CTRB2 CTRB1

6.79e-0531092CID000017130
DrugP 1 21 1

CYLD DIAPH2

6.79e-0531092CID000018450
Drug2-propyl methylphosphonochloridate

CTRB2 CTRB1

6.79e-0531092CID000102124
DrugFK-316

CTRB2 CTRB1

6.79e-0531092CID000133688
DrugAC1L19T8

CTRB2 CTRB1

6.79e-0531092CID000000694
DrugMarinostatin D

CTRB2 CTRB1

6.79e-0531092CID000132206
DrugN(3)ATP

MGAM CFTR

6.79e-0531092CID000133414
Drug1FD7

CTRB2 CTRB1

6.79e-0531092CID000445579
DrugGlt-leu-phe-nh-meq

CTRB2 CTRB1

6.79e-0531092CID000194914
DrugAC1L4Z4F

CTRB2 CTRB1

6.79e-0531092CID000194913
DrugGlt-Phe-NH-FMeq

CTRB2 CTRB1

6.79e-0531092CID000194912
Drugdiacetyl trimer

CTRB2 CTRB1

6.79e-0531092CID000193527
DrugFK-448

CTRB2 CTRB1

6.79e-0531092CID006917869
DrugAc-Phe-OMe

CTRB2 CTRB1

6.79e-0531092CID000097805
Drugthiobenzyl N-heptafluorobutyrylanthranilate

CTRB2 CTRB1

6.79e-0531092CID000133906
DrugDMPX

CFTR GHSR MSX2 LTB4R

8.22e-05481094CID000099562
Drugalizarin red S

CFTR OPN1SW ABCC6 MSX2 BMP2

9.43e-05951095CID000008534
DrugppcA

MGAM MAN2C1 SLC33A1

9.78e-05191093CID000125885
Drugphenylmethyl

RGL3 CTRB2 LTB4R CTRB1

1.21e-04531094CID000123147
DrugBenzoyl-dl-leucine

CTRB2 CTRB1

1.35e-0441092CID000294887
DrugAcafcek

CTRB2 CTRB1

1.35e-0441092CID000197677
DrugB-1,3-od

CTRB2 CTRB1

1.35e-0441092CID011971053
Drugdehydromerodesmosine

CTRB2 CTRB1

1.35e-0441092CID006443540
Drugalpha-amyrin palmitate

CTRB2 CTRB1

1.35e-0441092CID000185477
Drugpoly-THIQ

CTRB2 CTRB1

1.35e-0441092CID006453487
DrugN-(4-carboxycyclohexylmethyl)-maleimide

CTRB2 CTRB1

1.35e-0441092CID011548799
DrugG2505_sigma

CTRB2 CTRB1

1.35e-0441092CID000111098
Drugp-fluorobenzenesulfonyl chloride

CTRB2 CTRB1

1.35e-0441092CID000009588
DrugBSSDA

CTRB2 CTRB1

1.35e-0441092CID003081106
Drugbiotinamidocaproyl hydrazide

EPO RGL3

1.35e-0441092CID000083900
DrugAC1L2HV6

CTRB2 CTRB1

1.35e-0441092CID000047328
DrugAC1L4X1Z

CTRB2 CTRB1

1.35e-0441092CID000193815
DrugNSC-676827

CTRB2 CTRB1

1.35e-0441092CID000385555
Drug6-amino-1,2-benzopyrone

CTRB2 CTRB1

1.35e-0441092CID000046152
Drugnitrophenylethanol

CTRB2 CTRB1

1.35e-0441092CID000097851
DrugA0666_sigma

SLC4A7 RGL3 SLC9A2 SYN2

1.51e-04561094CID000005680
Drugbicarbonate

MGAM CAD SLC4A7 CFTR CTRB2 OPN1SW SLC9A2 CTRB1

1.72e-043251098CID000000767
DrugAc-Trp-OEt

CTRB2 CTRB1

2.25e-0451092CID000304749
DrugIcsl

CFTR C4A

2.25e-0451092CID000172743
Drug3-Cppap

ABCC6 PHEX

2.25e-0451092CID000194170
Drugapne

CTRB2 CTRB1

2.25e-0451092CID000098192
Drugcalcium nitrate tetrahydrate

MGAM CFTR

2.25e-0451092CID000026061
Drug7-chloro-4-nitrobenzofuran

CTRB2 CTRB1

2.25e-0451092CID000130782
DrugZ-Phe-Leu

CTRB2 CTRB1

2.25e-0451092CID000333351
Drug5'-FSBAzA

CTRB2 CTRB1

2.25e-0451092CID000130430
DrugAC1L3F57

CTRB2 CTRB1

2.25e-0451092CID000139565
Drug3,5-dimethylpyrazole-1-carboxamidine

CTRB2 CTRB1

2.25e-0451092CID000097525
DrugMaap-borov

CTRB2 CTRB1

2.25e-0451092CID005486914
Diseaselevel of chymotrypsinogen B2 in blood serum

CTRB2 CTRB1

1.30e-0521072OBA_2041192
Diseasemean arterial pressure

SLC4A7 RGS7BP PCNX3 MYO9B RGL3 PKP4 CAPZA1 DOCK10 HLCS PPARD

1.42e-0549910710EFO_0006340
Diseasechymotrypsinogen B measurement

CTRB2 CTRB1

3.90e-0531072EFO_0801477
DiseaseColorectal Carcinoma

CAD CFTR FRMPD2 KCNB2 ABCC6 BMP2 ABCE1 DNAH8 SLC33A1 ANAPC4 NLRP8

5.00e-0570210711C0009402
Diseasemitochondrial heteroplasmy measurement

MGAM BMP2 LONP1 DGUOK

1.18e-04691074EFO_0600008
Diseasesystemic lupus erythematosus

PCNX3 DOCK10 PPARD CPT2 OPN1SW SYNGAP1 PRR14 CIITA SYN2 C4B L3MBTL3

1.57e-0479910711MONDO_0007915
Diseasesyndromic X-linked intellectual disability (implicated_via_orthology)

PHF2 KDM7A

3.60e-0481072DOID:0060309 (implicated_via_orthology)
Diseasepancreatitis (biomarker_via_orthology)

DUSP1 CTRB2 CTRB1

3.85e-04391073DOID:4989 (biomarker_via_orthology)
Diseasecystic fibrosis (implicated_via_orthology)

CFTR CLCN2

4.61e-0491072DOID:1485 (implicated_via_orthology)
Diseasespleen volume

MYO9B SYN2 L3MBTL3

5.15e-04431073EFO_0600047
Diseasetooth agenesis (is_implicated_in)

MSX1 BMP2

5.75e-04101072DOID:0050591 (is_implicated_in)
Diseasetrypsin-2 measurement

CTRB2 CTRB1

7.01e-04111072EFO_0008305
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

CAPZA1 CAPZA2 SYNGAP1

7.57e-04491073DOID:0060037 (implicated_via_orthology)
DiseaseCooley's anemia

EPO CAD

8.40e-04121072C0002875
DiseaseThalassemia Intermedia

EPO CAD

8.40e-04121072C0271979
DiseaseThalassemia Minor

EPO CAD

8.40e-04121072C0085578
Diseasebeta Thalassemia

EPO CAD

8.40e-04121072C0005283
DiseaseRhabdomyosarcoma

FGFR4 ALK

1.33e-03151072C0035412
DiseaseHemoglobin F Disease

EPO CAD

1.33e-03151072C0019025
Diseasesystemic lupus erythematosus (is_implicated_in)

CIITA C4A C4B

1.50e-03621073DOID:9074 (is_implicated_in)
Diseasediet measurement

MGAM TMPRSS5 PHF2 ZNF469 STON2 NGEF PCDHGB4 PRKDC PLCG2 NIPBL ANAPC4

1.50e-03104910711EFO_0008111
DiseaseUremia

EPO BMP2

1.71e-03171072C0041948
DiseaseCardiomyopathies, Primary

EPO PDK2 PPARD

2.04e-03691073C0033141
DiseaseMyocardial Diseases, Secondary

EPO PDK2 PPARD

2.04e-03691073C0036529
Diseasemelanoma

EPO MYO7A UBR4 PPARD ALK

2.13e-032481075C0025202
DiseaseLupus Erythematosus, Systemic

PCNX3 C4A C4B

2.22e-03711073C0024141
Diseasechildhood trauma measurement, alcohol consumption measurement

PCDHGB5 OSBPL5 PCDHGB4

2.22e-03711073EFO_0007878, EFO_0007979
DiseaseCraniosynostosis

MSX2 BMP2

2.37e-03201072C0010278
DiseaseCraniofacial Abnormalities

PHEX MSX1 MSX2 NIPBL

2.54e-031561074C0376634
Diseaseprogression free survival, ovarian serous carcinoma

MGAM MSX1

2.87e-03221072EFO_0004920, EFO_1001516
Diseasehemoglobin A1 measurement

MGAM MYO9B CTRB2 SYN2 CTRB1 L3MBTL3 ANAPC4

2.91e-035201077EFO_0007629
DiseaseAlcoholic Intoxication, Chronic

CFTR GHSR STON2 OSBPL5 ALK

2.98e-032681075C0001973

Protein segments in the cluster

PeptideGeneStartEntry
FITPVSTLERDRFKS

PKP4

1011

Q99569
FLKAPQSFRAELSSI

SLC33A1

61

O00400
ITLLKLATPARFSQT

CTRB2

121

Q6GPI1
PSSFTRTRTSFLKAL

DISP3

1346

Q9P2K9
RSEDSTRRLFKFPFL

ANAPC4

561

Q9UJX5
LFRQAISPSDRVKLF

CFTR

1436

P13569
SSFFTLSLQKPRLLL

C4B

11

P0C0L5
QAFPKLVRILTAFSS

CIITA

971

P33076
SDTTFKALRRQLPVT

CAPZA1

251

P52907
VQKLSRFPLARQFSL

FGFR4

406

P22455
QTFSFLSRLKVQLEP

DGUOK

111

Q16854
LSTLDPKTISFRSRV

ACOT9

266

Q9Y305
LRNLFDSIKSEPFSI

CYTH4

231

Q9UIA0
QPRLSSILFKLTFEE

DIAPH2

791

O60879
TANSKFPVTRLLDTR

BMP2

181

P12643
ITFKRLIRFVPSSLS

CPT2

186

P23786
RPSRSTRSSIFQISK

RGS7BP

11

Q6MZT1
RLSESQLSFRRSPTK

RBM14

616

Q96PK6
KSRAPQFTILARTSL

ODF3B

196

A8MYP8
FSVQELPTRKLRVSS

PCDHGB4

56

Q9UN71
AQRRSAVFLSFKSPI

L3MBTL3

666

Q96JM7
LILDSFLTPRKTISF

OR13C6P

81

Q8NH95
LILDSFLTPRKTISF

OR13C7

81

P0DN81
TFIKELRSRVFPSAD

KDM7A

121

Q6ZMT4
DSNIRLTTKSFRPFV

LBP

311

P18428
FNTPLSILDRSTRQK

nan

146

O00370
TFQARPLSADLTKLF

KIAA1671

501

Q9BY89
ISSLFPTRAENFSRK

NLRP8

431

Q86W28
RFNTTKVVSTFNLPL

ARRDC5

261

A6NEK1
VFPNKRSFILTRSTF

MGAM

601

O43451
TPEDFNLLKSSNFRR

HLCS

346

P50747
KSFLTLTQPDRALVR

PCNX3

251

Q9H6A9
RPFSRFSVDKLLSVF

OR4K14

261

Q8NGD5
DRFPITLLQTSLKFT

DNAH8

4001

Q96JB1
RTPSDFKALRTVSVL

GPR119

216

Q8TDV5
IFTSLARLPTSKRSL

NIPBL

1456

Q6KC79
FLRSIIKTTPSQFST

NIPBL

1726

Q6KC79
STLFVETSLRRPQDK

LONP1

776

P36776
STSAEPLSRSIFRKF

HS3ST3A1

11

Q9Y663
FSFRKSTPERRTVQV

PLCG2

31

P16885
FSVQELPTRKLRVSS

PCDHGB5

56

Q9Y5G0
TLLQPTVNKFSLRVF

HCN3

51

Q9P1Z3
SREPLSTFRKLSQIF

RGL3

366

Q3MIN7
SLAVARPFVSQKLRT

LTB4R

116

Q15722
EKTSFTFLRQELPVR

PDK2

46

Q15119
QRLIKRAPFSISAFS

PARP11

101

Q9NR21
NKFLSQLEITFRRDP

ABCE1

556

P61221
PFERLAFVLSSNSLK

KLHL13

236

Q9P2N7
QKLFPFSSRERRSFT

KCNB2

791

Q92953
FPFEASLLTSVARRK

DACT2

591

Q5SW24
SRFSPLFRQESSKIS

DOCK10

576

Q96BY6
EFVKQRRSIISPNFS

DUSP1

286

P28562
RLLGFEPFSQRKLST

GHSR

336

Q92847
LLIVGFTSRFKRQTS

CD1D

316

P15813
FLQRRSKFSRPEFIL

FRMPD2

301

Q68DX3
RTFSVIKIFPDLSSN

CC2D1A

641

Q6P1N0
PLRTITADTFRKLFR

EPO

156

P01588
LLAVTRPFISSKFSQ

BNIP2

256

Q12982
KFTSSSDIPVEFIRR

C3orf33

61

Q6P1S2
AFFKLTLSRSPLVSQ

MS4A14

206

Q96JA4
DNRLKLTFSPFQVLS

MAN2C1

1016

Q9NTJ4
LSPRTSNVRSTFFKD

FAM118B

111

Q9BPY3
FAFSSVLDTVLLRPK

CYLD

611

Q9NQC7
TLVSPFIDDNTRRKF

SEC14L1

446

Q92503
EINVTLKFTSRFIRP

CFAP47

1931

Q6ZTR5
LKFTSRFIRPAEASL

CFAP47

1936

Q6ZTR5
SLSTPERSFIFINSR

PMS1

251

P54277
ITLLKLATPARFSQT

CTRB1

121

P17538
SSFFTLSLQKPRLLL

C4A

11

P0C0L4
SSEVRLKRFTLQFLP

FAM126B

66

Q8IXS8
TPNITKLRTDLRFIA

UPF2

256

Q9HAU5
TFVLEPRSFLNKLSD

OSBPL5

391

Q9H0X9
DLRLVTIPSFFSKSA

OPN1SW

281

P03999
RTPFTTSQLLALERK

MSX2

146

P35548
AETIRSLRKSFASLF

SYN2

566

Q92777
EKRFTSRIPLVRSFA

SLC4A7

221

Q9Y6M7
SQLFIKELRSRTFPS

PHF2

86

O75151
RTILAVTRPFISSKF

PRUNE2

3006

Q8WUY3
FVTREFLRSLRKPFS

PPARD

311

Q03181
LLTISLNRTFPFSLQ

SOCS5

471

O75159
QLSVKDSFRDLFIPR

LIPI

26

Q6XZB0
RTPFTTAQLLALERK

MSX1

176

P28360
LSLIISDVFRFTVPK

ABCC6

316

O95255
FLSLRPEEKFSSRAV

RECQL4

1146

O94761
ARFTILPSESLNKFE

OVCH1

526

Q7RTY7
LAPLFRSVRSKLESF

PRR14

246

Q9BWN1
LAPNRRTKFVSFTSR

NGEF

596

Q8N5V2
RFRTVFAEKTLPFTL

STON2

676

Q8WXE9
RKSLAVDFVVPSLFR

ALK

51

Q9UM73
SDTTFKALRRQLPVT

CAPZA2

251

P47755
FLTREEVLSRKPAST

CCDC15

206

Q0P6D6
KTTRFGTLFERLNSL

C12orf40

216

Q86WS4
TITALFKTRFRLDFP

CLCN2

301

P51788
FRASQFRFLQTSPKI

PNMA5

241

Q96PV4
RRKINTFISFPLELD

USP51

606

Q70EK9
QTRFLSVTLVFPSKS

USP43

276

Q70EL4
SVTLVFPSKSQRFLR

USP43

281

Q70EL4
RSQPRSISESFLTVK

SSH2

31

Q76I76
SQPKLDRTSSFRQIL

SYNGAP1

146

Q96PV0
INRFRTIPLTFKDQF

SLC9A2

416

Q9UBY0
FRPIRKRLSSTSSEE

PROM2

806

Q8N271
SRPTFSITKEFILRF

TMEM232

41

C9JQI7
SRFSNIKTLDDLFPL

XRN1

841

Q8IZH2
LPKTVSFRINSEDFL

TMPRSS5

106

Q9H3S3
SERKFSLLQTLATFR

PHEX

181

P78562
AFVTFRATRKPLVQT

RNF121

116

Q9H920
NVRVSRSFPFVSKTL

CAD

1216

P27708
RKDDPRLSFTRQSFV

PRKDC

1806

P78527
LPLRATDFEVLSTKF

ZNF469

3011

Q96JG9
LLKFFRPENITVSSR

TRAPPC8

1286

Q9Y2L5
RQTIRSKRPALFSSS

GTF3C5

456

Q9Y5Q8
QLFSGRSDFRITTLK

WDR25

326

Q64LD2
RTSKLTTFVNFPLRD

USP2

511

O75604
LPSSKIRDVTFLFNE

UBR4

2041

Q5T4S7
QLFSLPSRTRSSKDL

ZFYVE16

651

Q7Z3T8
RSPTLSSQFKRSLEL

MYO7A

606

Q13402
FLPKTRRQIFSLLSA

MYO9A

411

B2RTY4
RRTSFSTSDVSKLLP

MYO9B

1351

Q13459