Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpyrophosphatase activity

PRUNE2 ABCA4 MCM9 NAIP MFN2 INO80 ENPP4 NUDT9 DNAH8 MFN1 TBCC VCP DNAH11

1.53e-058397613GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

PRUNE2 ABCA4 MCM9 NAIP MFN2 INO80 ENPP4 NUDT9 DNAH8 MFN1 TBCC VCP DNAH11

1.54e-058407613GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

PRUNE2 ABCA4 MCM9 NAIP MFN2 INO80 ENPP4 NUDT9 DNAH8 MFN1 TBCC VCP DNAH11

1.54e-058407613GO:0016818
GeneOntologyMolecularFunctionMHC class I protein binding

HLA-A HLA-H VCP

2.43e-0432763GO:0042288
GeneOntologyMolecularFunctionTAP complex binding

HLA-A HLA-H

5.06e-049762GO:0062061
GeneOntologyMolecularFunctionCD8 receptor binding

HLA-A HLA-H

5.06e-049762GO:0042610
GeneOntologyMolecularFunctionTAP1 binding

HLA-A HLA-H

6.31e-0410762GO:0046978
GeneOntologyMolecularFunctionTAP2 binding

HLA-A HLA-H

6.31e-0410762GO:0046979
GeneOntologyMolecularFunctionTAP binding

HLA-A HLA-H

6.31e-0410762GO:0046977
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

ABCA4 MCM9 NAIP MFN2 INO80 DNAH8 MFN1 TBCC VCP DNAH11

6.89e-047757610GO:0017111
GeneOntologyMolecularFunctionbeta-2-microglobulin binding

HLA-A HLA-H

9.21e-0412762GO:0030881
GeneOntologyMolecularFunctionsmall GTPase binding

UNC13B FLNA GGA2 IPO9 MFN2 FGD5

1.40e-03321766GO:0031267
GeneOntologyMolecularFunctionMHC protein binding

HLA-A HLA-H VCP

1.41e-0358763GO:0042287
GeneOntologyMolecularFunctionATP hydrolysis activity

ABCA4 MCM9 NAIP INO80 DNAH8 VCP DNAH11

1.44e-03441767GO:0016887
GeneOntologyMolecularFunctiondiacylglycerol binding

UNC13B UNC13A

1.66e-0316762GO:0019992
GeneOntologyMolecularFunctionnatural killer cell lectin-like receptor binding

HLA-A HLA-H

1.87e-0317762GO:0046703
GeneOntologyMolecularFunctionmRNA regulatory element binding translation repressor activity

CPEB2 CPEB4

1.87e-0317762GO:0000900
GeneOntologyMolecularFunctionminus-end-directed microtubule motor activity

DNAH8 DNAH11

2.10e-0318762GO:0008569
GeneOntologyMolecularFunctionGTPase binding

UNC13B FLNA GGA2 IPO9 MFN2 FGD5

2.49e-03360766GO:0051020
GeneOntologyMolecularFunctionT cell receptor binding

HLA-A HLA-H

2.60e-0320762GO:0042608
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13B UNC13A

3.74e-0324762GO:0017075
GeneOntologyBiologicalProcessdense core granule docking

UNC13B UNC13A

1.34e-052762GO:0061790
GeneOntologyBiologicalProcessdense core granule exocytosis

UNC13B CADPS2 UNC13A

2.12e-0515763GO:1990504
GeneOntologyBiologicalProcesspositive regulation of mitochondrial membrane potential

MFN2 MFN1 VCP

2.60e-0516763GO:0010918
GeneOntologyBiologicalProcessdense core granule priming

UNC13B UNC13A

8.00e-054762GO:0061789
GeneOntologyBiologicalProcesspositive regulation of membrane potential

MFN2 MFN1 VCP

1.04e-0425763GO:0045838
GeneOntologyBiologicalProcessdense core granule localization

UNC13B CADPS2 UNC13A

1.47e-0428763GO:0032253
GeneOntologyCellularComponentGolgi medial cisterna

HLA-A HLA-H ST3GAL1

7.76e-0523763GO:0005797
GeneOntologyCellularComponentMHC class Ib protein complex

HLA-A HLA-H

2.71e-047762GO:0032398
GeneOntologyCellularComponentficolin-1-rich granule

COPB1 PTPRN2 GUSB ENPP4 VCP

5.72e-04185765GO:0101002
GeneOntologyCellularComponentMHC class I protein complex

HLA-A HLA-H

5.76e-0410762GO:0042612
GeneOntologyCellularComponentcell cortex region

UNC13B UNC13A NLRP5

5.87e-0445763GO:0099738
DomainDUF1041

UNC13B CADPS2 UNC13A

6.18e-075753SM01145
DomainDUF1041

UNC13B CADPS2 UNC13A

2.15e-067753PF06292
DomainMunc13_1

UNC13B CADPS2 UNC13A

2.15e-067753IPR014770
DomainCAPS_dom

UNC13B CADPS2 UNC13A

2.15e-067753IPR010439
DomainMHD1

UNC13B CADPS2 UNC13A

2.15e-067753PS51258
DomainMitofusin_fam

MFN2 MFN1

1.59e-052752IPR027094
DomainFzo_mitofusin

MFN2 MFN1

1.59e-052752PF04799
DomainFzo/mitofusin_HR2

MFN2 MFN1

1.59e-052752IPR006884
DomainAAA+_ATPase

ABCA4 MCM9 NAIP DNAH8 VCP DNAH11

2.46e-05144756IPR003593
DomainAAA

ABCA4 MCM9 NAIP DNAH8 VCP DNAH11

2.46e-05144756SM00382
DomainUnc-13

UNC13B UNC13A

4.76e-053752IPR027080
DomainCEBP_ZZ

CPEB2 CPEB4

9.50e-054752IPR032296
DomainCEBP_ZZ

CPEB2 CPEB4

9.50e-054752PF16366
DomainRRM_7

CPEB2 CPEB4

9.50e-054752PF16367
DomainNACHT

CIITA NAIP NLRP5

1.04e-0423753PS50837
DomainNACHT_NTPase

CIITA NAIP NLRP5

1.04e-0423753IPR007111
DomainMunc13_dom-2

UNC13B UNC13A

1.58e-045752IPR014772
DomainMembr_traf_MHD

UNC13B UNC13A

1.58e-045752PF10540
DomainMHD2

UNC13B UNC13A

1.58e-045752PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13A

1.58e-045752IPR019558
DomainDMAP_binding

DIP2A DIP2C

1.58e-045752PF06464
DomainMHC_I_a_C

HLA-A HLA-H

2.36e-046752IPR010579
DomainDMAP1-bd

DIP2A DIP2C

2.36e-046752IPR010506
DomainMHC_I_C

HLA-A HLA-H

2.36e-046752PF06623
DomainDMAP_binding

DIP2A DIP2C

2.36e-046752SM01137
DomainDHC_N1

DNAH8 DNAH11

4.39e-048752PF08385
DomainDynein_heavy_dom-1

DNAH8 DNAH11

4.39e-048752IPR013594
DomainP-loop_NTPase

ABCA4 CIITA MCM9 NAIP MFN2 INO80 DNAH8 MFN1 VCP DNAH11 NLRP5

5.44e-048487511IPR027417
DomainDynein_heavy_chain_D4_dom

DNAH8 DNAH11

1.40e-0314752IPR024317
DomainDynein_HC_stalk

DNAH8 DNAH11

1.40e-0314752IPR024743
DomainDynein_heavy_dom-2

DNAH8 DNAH11

1.40e-0314752IPR013602
DomainG_DYNAMIN_dom

MFN2 MFN1

1.40e-0314752IPR030381
DomainDHC_N2

DNAH8 DNAH11

1.40e-0314752PF08393
DomainMT

DNAH8 DNAH11

1.40e-0314752PF12777
DomainAAA_8

DNAH8 DNAH11

1.40e-0314752PF12780
DomainATPase_dyneun-rel_AAA

DNAH8 DNAH11

1.40e-0314752IPR011704
DomainG_DYNAMIN_2

MFN2 MFN1

1.40e-0314752PS51718
DomainAAA_5

DNAH8 DNAH11

1.40e-0314752PF07728
DomainDHC_fam

DNAH8 DNAH11

1.62e-0315752IPR026983
DomainDynamin_GTPase

MFN2 MFN1

1.62e-0315752IPR001401
DomainDynamin_N

MFN2 MFN1

1.62e-0315752PF00350
DomainDynamin_SF

MFN2 MFN1

1.62e-0315752IPR022812
DomainDynein_heavy_dom

DNAH8 DNAH11

1.62e-0315752IPR004273
DomainDynein_heavy

DNAH8 DNAH11

1.62e-0315752PF03028
DomainC2

UNC13B PLCL1 CADPS2 UNC13A

1.91e-03131754PF00168
DomainC2

UNC13B PLCL1 CADPS2 UNC13A

2.25e-03137754SM00239
DomainC2

UNC13B PLCL1 CADPS2 UNC13A

2.56e-03142754PS50004
Domain-

ABCA4 MCM9 NAIP MFN2 INO80 DNAH8 MFN1 VCP DNAH11

2.93e-037467593.40.50.300
DomainMHC_I

HLA-A HLA-H

3.18e-0321752PF00129
DomainMHC_I_a_a1/a2

HLA-A HLA-H

3.18e-0321752IPR001039
DomainActinin_actin-bd_CS

FLNA PLEC

3.81e-0323752IPR001589
DomainACTININ_2

FLNA PLEC

3.81e-0323752PS00020
DomainACTININ_1

FLNA PLEC

3.81e-0323752PS00019
DomainC2_dom

UNC13B PLCL1 CADPS2 UNC13A

4.29e-03164754IPR000008
DomainAMP-binding

DIP2A DIP2C

6.44e-0330752PF00501
DomainAMP-dep_Synth/Lig

DIP2A DIP2C

6.44e-0330752IPR000873
DomainAlkaline_phosphatase_core

ENPP4 ALPI

6.86e-0331752IPR017850
DomainAlkaline_Pase-like_a/b/a

ENPP4 ALPI

6.86e-0331752IPR017849
Pubmed

VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.

MFN2 MFN1 VCP

1.00e-08376323498974
Pubmed

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L.

OMA1 MFN2 MFN1

1.00e-07576335172139
Pubmed

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin.

MFN2 MFN1 VCP

1.00e-07576321173115
Pubmed

Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.

UNC13B ABCA4 UNC13A

1.00e-07576333139401
Pubmed

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.

UNC13B CADPS2 UNC13A

2.00e-07676328635948
Pubmed

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

UNC13B CADPS2 UNC13A

5.57e-07876325609709
Pubmed

An MHC class Ib-restricted CD8+ T cell response to lymphocytic choriomeningitis virus.

HLA-A CIITA HLA-H

8.34e-07976322084437
Pubmed

Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases.

HLA-A CIITA HLA-H

8.34e-07976317088432
Pubmed

Polyclonal MHC Ib-restricted CD8+ T cells undergo homeostatic expansion in the absence of conventional MHC-restricted T cells.

HLA-A CIITA HLA-H

8.34e-07976318292501
Pubmed

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.

UNC13B CADPS2 UNC13A

1.19e-061076321040848
Pubmed

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.

UNC13B CADPS2 UNC13A

1.63e-061176325374362
Pubmed

Charting the landscape of tandem BRCT domain-mediated protein interactions.

UNC13B FLNA DCAF13 IPO9 TEX101 ZBTB10 BEND3 TSEN54 SSR1 NKAPL

2.00e-06670761022990118
Pubmed

Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance.

MFN2 MFN1

4.71e-06276224074867
Pubmed

Mfn2 is critical for brown adipose tissue thermogenic function.

MFN2 MFN1

4.71e-06276228348166
Pubmed

Mitofusin1 in oocyte is essential for female fertility.

MFN2 MFN1

4.71e-06276230690319
Pubmed

Mitofusins modulate the increase in mitochondrial length, bioenergetics and secretory phenotype in therapy-induced senescent melanoma cells.

MFN2 MFN1

4.71e-06276231431479
Pubmed

Restoring mitofusin balance prevents axonal degeneration in a Charcot-Marie-Tooth type 2A model.

MFN2 MFN1

4.71e-06276230882371
Pubmed

The effect of gestational diabetes on the expression of mitochondrial fusion proteins in placental tissue.

MFN2 MFN1

4.71e-06276234600274
Pubmed

A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space.

MFN2 MFN1

4.71e-06276229212658
Pubmed

Cloning, genomic organization and expression pattern of a novel Drosophila gene, the disco-interacting protein 2 (dip2), and its murine homolog.

DIP2A DIP2C

4.71e-06276212137943
Pubmed

Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations.

MFN2 MFN1

4.71e-06276217296794
Pubmed

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.

UNC13B UNC13A

4.71e-06276212070347
Pubmed

Mitofusin 1 is required for oocyte growth and communication with follicular somatic cells.

MFN2 MFN1

4.71e-06276232281181
Pubmed

Regulation of insulin exocytosis by Munc13-1.

UNC13B UNC13A

4.71e-06276212871971
Pubmed

Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

UNC13B UNC13A

4.71e-06276217561838
Pubmed

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.

UNC13B UNC13A

4.71e-06276223070049
Pubmed

MFN1 and MFN2 Are Dispensable for Sperm Development and Functions in Mice.

MFN2 MFN1

4.71e-06276234948301
Pubmed

Mitochondrial Dynamics in Tachycardiomyopathy.

MFN2 MFN1

4.71e-06276230873819
Pubmed

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.

UNC13B UNC13A

4.71e-06276228489077
Pubmed

MFN2 interacts with nuage-associated proteins and is essential for male germ cell development by controlling mRNA fate during spermatogenesis.

MFN2 MFN1

4.71e-06276233674260
Pubmed

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

UNC13B UNC13A

4.71e-06276210440375
Pubmed

Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.

UNC13B UNC13A

4.71e-06276222066784
Pubmed

Loss of mitofusin 2 promotes endoplasmic reticulum stress.

MFN2 MFN1

4.71e-06276222511781
Pubmed

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.

UNC13B UNC13A

4.71e-06276232187536
Pubmed

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

UNC13B UNC13A

4.71e-06276228772123
Pubmed

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

UNC13B UNC13A

4.71e-06276217267576
Pubmed

Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.

UNC13B UNC13A

4.71e-06276222814762
Pubmed

Mitofusin 2 tethers endoplasmic reticulum to mitochondria.

MFN2 MFN1

4.71e-06276219052620
Pubmed

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

UNC13B UNC13A

4.71e-06276228426965
Pubmed

The heptad repeat domain 1 of Mitofusin has membrane destabilization function in mitochondrial fusion.

MFN2 MFN1

4.71e-06276229661855
Pubmed

Endoplasmic reticulum-mitochondrial interaction mediated by mitofusin-1 or mitofusin-2 is not required for lipid droplet formation or adipocyte differentiation.

MFN2 MFN1

4.71e-06276227404125
Pubmed

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.

UNC13B UNC13A

4.71e-06276235613050
Pubmed

Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.

UNC13B UNC13A

4.71e-06276223770256
Pubmed

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

UNC13B UNC13A

4.71e-06276230816091
Pubmed

Mitofusin 1 overexpression rescues the abnormal mitochondrial dynamics caused by the Mitofusin 2 K357T mutation in vitro.

MFN2 MFN1

4.71e-06276237220142
Pubmed

A catalytic domain variant of mitofusin requiring a wildtype paralog for function uncouples mitochondrial outer-membrane tethering and fusion.

MFN2 MFN1

4.71e-06276230936207
Pubmed

Adult skeletal muscle deletion of Mitofusin 1 and 2 impedes exercise performance and training capacity.

MFN2 MFN1

4.71e-06276230260752
Pubmed

A common molecular basis for membrane docking and functional priming of synaptic vesicles.

UNC13B UNC13A

4.71e-06276219558619
Pubmed

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.

UNC13B UNC13A

4.71e-06276218701688
Pubmed

Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

UNC13B UNC13A

4.71e-06276231851910
Pubmed

Mitofusins are required for angiogenic function and modulate different signaling pathways in cultured endothelial cells.

MFN2 MFN1

4.71e-06276221839087
Pubmed

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.

UNC13B UNC13A

4.71e-06276211832228
Pubmed

Mitofusin 2-containing mitochondrial-reticular microdomains direct rapid cardiomyocyte bioenergetic responses via interorganelle Ca(2+) crosstalk.

MFN2 MFN1

4.71e-06276222777004
Pubmed

Structural basis of mitochondrial tethering by mitofusin complexes.

MFN2 MFN1

4.71e-06276215297672
Pubmed

Munc13 controls the location and efficiency of dense-core vesicle release in neurons.

UNC13B UNC13A

4.71e-06276223229896
Pubmed

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.

MFN2 MFN1

4.71e-06276212759376
Pubmed

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.

UNC13B UNC13A

4.71e-06276211792326
Pubmed

Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.

MFN2 MFN1

4.71e-06276211950885
Pubmed

MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation.

MFN2 MFN1

4.71e-06276232330448
Pubmed

Control of mitochondrial morphology by a human mitofusin.

MFN2 MFN1

4.71e-06276211181170
Pubmed

Mitochondrial toxic effects of Aβ through mitofusins in the early pathogenesis of Alzheimer's disease.

MFN2 MFN1

4.71e-06276224710686
Pubmed

A nucleotide deletion in exon 4 is responsible for an HLA-A null allele (A*0105N).

HLA-A HLA-H

4.71e-06276210519371
Pubmed

Evaluation of the role of mitofusin-1 and mitofusin-2 in periodontal disease.

MFN2 MFN1

4.71e-06276237436713
Pubmed

Distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion.

MFN2 MFN1

4.71e-06276224813948
Pubmed

Programme of self-reactive innate-like T cell-mediated cancer immunity.

HLA-A HLA-H FGD5

5.50e-061676335444279
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

OMA1 FLNA DCAF13 IPO9 TMTC3 HLA-A COPB1 MFN2 PLEC JMJD1C MFN1 VCP

1.12e-051203761229180619
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

SECISBP2L PRUNE2 IPO9 CPEB4 DIP2C ENPP4 FCHO1 JMJD1C

1.25e-0549376815368895
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

CPEB2 FLNA DIP2A COPB1 SIPA1L1 CPEB4 MTMR1 PLCL1 PLEC DDB1 UNC13A VCP DNAH11

1.25e-051431761337142655
Pubmed

Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.

UNC13B UNC13A

1.41e-05376237343100
Pubmed

Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.

MFN2 MFN1

1.41e-05376236050466
Pubmed

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

UNC13B UNC13A

1.41e-05376223658173
Pubmed

CPEB2, a novel putative translational regulator in mouse haploid germ cells.

CPEB2 CPEB4

1.41e-05376212672660
Pubmed

Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1.

MFN2 MFN1

1.41e-05376221615408
Pubmed

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction.

MFN2 MFN1

1.41e-05376227228353
Pubmed

Mitofusins 1/2 and ERRalpha expression are increased in human skeletal muscle after physical exercise.

MFN2 MFN1

1.41e-05376215961417
Pubmed

Role of cardiac mitofusins in cardiac conduction following simulated ischemia-reperfusion.

MFN2 MFN1

1.41e-05376236473917
Pubmed

Sonic Hedgehog Signaling Drives Mitochondrial Fragmentation by Suppressing Mitofusins in Cerebellar Granule Neuron Precursors and Medulloblastoma.

MFN2 MFN1

1.41e-05376226446920
Pubmed

Regulation of Mitofusin1 by Mahogunin Ring Finger-1 and the proteasome modulates mitochondrial fusion.

MFN2 MFN1

1.41e-05376227713096
Pubmed

DCAF13 promotes breast cancer cell proliferation by ubiquitin inhibiting PERP expression.

DCAF13 DDB1

1.41e-05376235178836
Pubmed

The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.

DCAF13 DDB1

1.41e-05376231492966
Pubmed

Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion.

MFN2 MFN1

1.41e-05376219477917
Pubmed

Analysis of mitochondrial regulatory transcripts in publicly available datasets with validation in placentae from pre-term, post-term and fetal growth restriction pregnancies.

MFN2 MFN1

1.41e-05376234364121
Pubmed

Mitochondrial fusion is required for regulation of mitochondrial DNA replication.

MFN2 MFN1

1.41e-05376231170154
Pubmed

Associations between OPA1, MFN1, and MFN2 polymorphisms and primary open angle glaucoma in Polish participants of European ancestry.

MFN2 MFN1

1.41e-05376234425738
Pubmed

CGG-repeat expansion in the DIP2B gene is associated with the fragile site FRA12A on chromosome 12q13.1.

DIP2A DIP2C

1.41e-05376217236128
Pubmed

EET enhances renal function in obese mice resulting in restoration of HO-1-Mfn1/2 signaling, and decrease in hypertension through inhibition of sodium chloride co-transporter.

MFN2 MFN1

1.41e-05376229787809
Pubmed

Mitofusin-2 maintains mitochondrial structure and contributes to stress-induced permeability transition in cardiac myocytes.

MFN2 MFN1

1.41e-05376221245373
Pubmed

Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.

UNC13B UNC13A

1.41e-05376217639022
Pubmed

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.

MFN2 MFN1

1.41e-05376224513856
Pubmed

Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta.

MFN2 MFN1

1.41e-05376218974884
Pubmed

Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence.

MFN2 MFN1

1.41e-05376229107503
Pubmed

Disruption of fusion results in mitochondrial heterogeneity and dysfunction.

MFN2 MFN1

1.41e-05376215899901
Pubmed

Drp1 levels constitutively regulate mitochondrial dynamics and cell survival in cortical neurons.

MFN2 MFN1

1.41e-05376219445933
Pubmed

Regulation of mitophagy by the Gp78 E3 ubiquitin ligase.

MFN2 MFN1

1.41e-05376223427266
Pubmed

Mitofusin 2 inhibits mitochondrial antiviral signaling.

MFN2 MFN1

1.41e-05376219690333
Pubmed

Mitochondrial fusion is required for spermatogonial differentiation and meiosis.

MFN2 MFN1

1.41e-05376231596236
Pubmed

Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1.

MFN2 MFN1

1.41e-05376220661427
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13B UNC13A

1.41e-05376233105896
Pubmed

INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway.

INO80 DDB1

1.41e-05376220855601
Pubmed

Mitofusin 2 in Macrophages Links Mitochondrial ROS Production, Cytokine Release, Phagocytosis, Autophagy, and Bactericidal Activity.

MFN2 MFN1

1.41e-05376232846136
InteractionITGB1 interactions

FLNA CLEC4E GGA2 PTPRN2 TEX101 SSR1 PLEC DNAH8 DDB1 VCP

2.23e-064007510int:ITGB1
GeneFamilyUNC13 homologs

UNC13B UNC13A

5.84e-054572836
GeneFamilyNLR family

CIITA NAIP NLRP5

6.50e-0525573666
GeneFamilyDyneins, axonemal

DNAH8 DNAH11

1.29e-0317572536
ToppCellPND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CPEB2 RNF141 C2 TSEN54 PLCL1 TBCC

2.33e-07153756489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCellmild-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SECISBP2L GGA2 CIITA SIPA1L1 SETBP1 ZBTB10

1.12e-06200756222789b897e2a683bbfd1d00b6fd8705015d90df
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|COVID-19 / Disease (COVID-19 only), tissue and cell type

DPP10 SI DNAH8 MGAT4C UNC13A

5.51e-061507550205318a870e091add66ee4305747dda9f51510d
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

GGA2 CIITA SIPA1L1 SETBP1 JMJD1C

8.25e-061637556bed27d2f67a430a847da5eb47878d14b4949c45
ToppCellMS-CD8-proli_CD4|MS / Condition, Cell_class and T cell subcluster

SLC16A6 TMTC3 RNF141 ZNF620 C2

1.07e-051727550b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCellfacs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PAXBP1 CIITA SMCO1 PLEC TRRAP

1.23e-05177755f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 PLCL1 CADPS2

1.52e-05185755673f0c688ae6984bc8027df2da335787924f4137
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Children_(3_yrs) / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 PLCL1 CADPS2

1.52e-0518575598b8ee42b89d97e4c9db01740e0c193503c68f2c
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRUNE2 DPP10 PTPRN2 MGAT4C UNC13A

1.56e-05186755b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 PLCL1 CADPS2

1.60e-0518775581cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SECISBP2L FSD1L PAXBP1 MTUS1 CADPS2

1.60e-0518775558d48128547ee3513d0bf7f78e61b76b1c472ca9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SECISBP2L CIITA SIPA1L1 SETBP1 ZBTB10

1.64e-05188755d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PRUNE2 DPP10 PTPRN2 MGAT4C UNC13A

1.64e-05188755c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GGA2 CIITA RNF141 SETBP1 DNAH8

1.69e-051897552b53dae0e6e85b7139f8a9872fbebb3705b2f1bf
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SECISBP2L CIITA SIPA1L1 SETBP1 ZBTB10

1.82e-05192755446c61c0d6ba89c619efe87ee495951299953981
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

SIPA1L1 SETBP1 DIP2C PLCL1 JMJD1C

1.82e-05192755e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SECISBP2L GGA2 SIPA1L1 SETBP1 JMJD1C

1.96e-05195755481989d2e5bd2582da3d86b0155c4d6615317067
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

SECISBP2L GGA2 SIPA1L1 SETBP1 JMJD1C

1.96e-051957556108a27523d1b93a7fbe35cb95704a5ad9071e3c
ToppCellControl_saline-Epithelial_alveolar-AT_2-Differentiating_AT2|Control_saline / Treatment groups by lineage, cell group, cell type

SECISBP2L UNC13B FSD1L MTUS1 CADPS2

2.06e-0519775544a59dfb889577b3160a5b13ada1276771a00241
ToppCellLPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

UNC13B FSD1L MTUS1 ST3GAL1 CADPS2

2.06e-051977551485933986921ff45669d9b7501c8d17050b3e97
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / Treatment groups by lineage, cell group, cell type

UNC13B FSD1L MTUS1 ST3GAL1 CADPS2

2.06e-051977551a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SECISBP2L UNC13B MTUS1 ZBTB10 C2

2.06e-05197755bf10727fbe90b71d2ac60a11711e5f0701b3799d
ToppCellSevere-B_intermediate-6|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

FLNA GGA2 CIITA RNF141 DNAH8

2.16e-05199755bf6ebb63ab361d9d1946225894d7be433e9befab
ToppCellmild-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

GGA2 CIITA SETBP1 ZBTB10 DNAH8

2.21e-05200755fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCellmild-B_intermediate|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

GGA2 CIITA SETBP1 ZBTB10 DNAH8

2.21e-052007558e3132a1fe3708f725c5c4077878fb87bbea3678
ToppCellCOVID-19-COVID-19_Severe-Lymphocyte-T/NK-gd_T|COVID-19_Severe / Disease, condition lineage and cell class

FLNA DIP2A HLA-A TSEN54 ENPP4

2.21e-05200755f72bc3f6606ae77fe1b0a972e35b3ce0727804d9
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

SECISBP2L PRUNE2 MTUS1 PLCL1 ENPP4

2.21e-05200755829978708463a7459fe1041bd90196775bc4b531
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Bcl6-Excitatory_Neuron.Slc17a7.Bcl6-Fos_(Layer_5a,_IEG+)|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

SMCO1 TEX101 NLRP5

4.20e-0540753b4c04100180790e1a53a15e8311e40015306c088
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FSD1L MTUS1 CADPS2 NLRP5

6.30e-051277545b0adbcafad31a6759c9bdce2f7f9591a8edc450
ToppCellMild/Remission-B_naive-4|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SECISBP2L CIITA SIPA1L1 ZBTB10

1.14e-04148754dd5e1bc02824e743e1c030a303e32f27a359a8ca
ToppCellCOVID-19-kidney-Technical/muscle|kidney / Disease (COVID-19 only), tissue and cell type

DPP10 PTPRN2 DNAH8 MGAT4C

1.14e-041487540dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

1.30e-04153754e7a074ea8232bacf924be78a244a8507c7e1ebc8
ToppCellfacs-Brain_Myeloid-Cortex-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA CLEC4E CIITA ST3GAL1

1.33e-041547541e088b0d4a44267f46a9b643f46a1aba784686b1
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

SLC16A6 PRELID2 DEF6 FCHO1

1.33e-04154754d0a1ff02a7e91f6923aa85b65094f78e357e377d
ToppCellCOVID-19-kidney-Technical/muscle_(Mes)|kidney / Disease (COVID-19 only), tissue and cell type

DPP10 PTPRN2 DNAH8 MGAT4C

1.50e-041597545335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Enterocyte_(Proximal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CPEB4 DIP2C FCHO1 ALPI

1.50e-04159754709b57f992a29878cc899d760d144d36cb5cb280
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SECISBP2L MTUS1 PLCL1 CADPS2

1.50e-041597548680b054622f573a82b1625fb93c2d5db81d1034
ToppCelldroplet-Liver-HEPATOCYTES-1m-Myeloid-Kupffer_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OMA1 DIP2A PRELID2 C2

1.54e-04160754a494001b1f6dec33624f98fa3c24bad6988d0425
ToppCelldroplet-Lung-nan-3m-Myeloid-Interstitial_Macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 CIITA GUSB UNC13A

1.58e-04161754f1d3287d9cb4e0eec99b3509f5dc4b87ae8c8cc9
ToppCelldroplet-Lung-nan-3m-Myeloid-lung_macrophage|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 CIITA GUSB UNC13A

1.58e-04161754110cc7122e3c9f105a11d811d77c8a8852b9de6c
ToppCellCOVID-19-kidney-Technical/muscle_(Imm)|kidney / Disease (COVID-19 only), tissue and cell type

DPP10 PTPRN2 MGAT4C UNC13A

1.65e-0416375419c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CLEC4E RNF141 FGD5 UNC13A

1.65e-04163754c21114826bee1b05b411984326fef6b6e0d05316
ToppCellE12.5-Endothelial-lymphatic_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CLEC4E RNF141 FGD5 UNC13A

1.65e-041637545d49414432db259a19df50d7944581d00b69f537
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPP10 PTPRN2 MGAT4C UNC13A

1.69e-04164754be49af6335f2505065cde2cb9800e4a5516811b1
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 CADPS2

1.77e-04166754c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l34|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RNF141 ZNF648 ST3GAL1 ICA1L

1.85e-0416875484977db9d71e59208727885320cc18d80d064380
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DIP2C IFT122 CADPS2 DNAH11

1.85e-041687549a8709d34865cfa668d8f3335dc34fc86fc32482
ToppCellMild/Remission-B_naive-4|Mild/Remission / disease group and sub_cluster of B and Plasma cells(res = 0.5)

SECISBP2L CIITA SIPA1L1 ZBTB10

1.90e-04169754c3a6179a64589a370108fea809b157839347759c
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

DPP10 PTPRN2 MGAT4C UNC13A

1.90e-04169754b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 PLCL1

1.94e-04170754a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellTCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium|TCGA-Endometrium / Sample_Type by Project: Shred V9

PRUNE2 PABPC5 PLCL1 NKAPL

1.94e-04170754cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCellTCGA-Endometrium-Solid_Tissue_Normal|TCGA-Endometrium / Sample_Type by Project: Shred V9

PRUNE2 PABPC5 PLCL1 NKAPL

1.94e-041707540bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCellTCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue|TCGA-Endometrium / Sample_Type by Project: Shred V9

PRUNE2 PABPC5 PLCL1 NKAPL

1.94e-04170754516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCellfacs-Lung-Endomucin-3m-Endothelial-Lymphatic_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 SMCO1 NKAPL NLRP5

2.03e-04172754b3c4adccc34bb9e4e78e40f4e2e23736c347cc75
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OMA1 PAXBP1 CIITA CPEB4

2.03e-04172754356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OMA1 PAXBP1 CIITA CPEB4

2.03e-0417275446fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Lung-Endomucin-3m-Endothelial-endothelial_cell_of_lymphatic_vessel|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PRUNE2 SMCO1 NKAPL NLRP5

2.03e-041727542f1673fcb2356684d60871debb0f159aec553a1c
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OMA1 PAXBP1 CIITA CPEB4

2.03e-04172754438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

GGA2 CIITA SIPA1L1 JMJD1C

2.07e-04173754d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellnormal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

FLNA GGA2 HLA-A ENPP4

2.07e-041737541e8a43ff32eab95857c794e0bf4f0b0dba155b4a
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Enterocyte|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SECISBP2L PLEC MGAT4C ALPI

2.12e-041747542fbdb62e269acf4447b171700a615e878dde7f9f
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-enterocyte_of_epithelium_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SECISBP2L PLEC MGAT4C ALPI

2.12e-041747547c52b5d8f1e65e5208c952be341fa155ed0e6e76
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GGA2 CIITA SIPA1L1 SETBP1

2.12e-04174754ebe6ce173ad12d4a2afa39f8d6185c0e4f97fb1e
ToppCellNS-moderate-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ENAM DPP10 DIP2C PLCL1

2.17e-04175754a1e0a15c69211d6db2edeb101476f0f6e08b90c8
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA SETBP1 DNAH8 UNC13A

2.17e-04175754316f2ea930437bf1243b1c0f45e6bd864112c6f2
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA SETBP1 DNAH8 UNC13A

2.17e-04175754a9f08e1e4c2997dcdd3e5d92daac480da19100b8
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UNC13B FLNA TSEN54 ENPP4

2.21e-041767545914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCellThalamus-Neuronal-Excitatory|Thalamus / BrainAtlas - Mouse McCarroll V32

DPP10 PTPRN2 MGAT4C UNC13A

2.21e-04176754d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-DC-cDC2-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLEC4E CIITA NAIP JMJD1C

2.21e-04176754a31d7532f8c055d4e62bbaa78d819f2495bfee00
ToppCellCaecum-Macrophage-LYVE1_Macrophage|Macrophage / Region, Cell class and subclass

TMTC3 MFN2 FCHO1

2.25e-047075305f8fc648641b9db50c2ae20d6246b52869957cf
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck-Head_and_Neck_normal_tissue|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FBXO40 SLC16A6 SMCO1 NKAPL

2.26e-04177754675003fbecee1b86919d1a6eeb268e1ca298f714
ToppCellTCGA-Head_and_Esophagus-Solid_Tissue_Normal-Head_and_Neck|TCGA-Head_and_Esophagus / Sample_Type by Project: Shred V9

FBXO40 SLC16A6 SMCO1 NKAPL

2.26e-0417775472d144289167f200ac9f006d130de31e45568484
ToppCell3'_v3-lymph-node_spleen-Mast-Mast_cell_lympho|lymph-node_spleen / Manually curated celltypes from each tissue

FSD1L SI DNAH8 ICA1L

2.26e-0417775453040dbeb18574a48e352e4bce252c7c3018762c
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.3.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FLNA GGA2 HLA-A C2

2.31e-041787540b398656f26c4061b11ccf98908d0e2e1367585a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 CADPS2

2.36e-04179754815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellLPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

2.36e-04179754fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Medullary_Thick_Ascending_Limb_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CPEB2 NAIP PLCL1 CADPS2

2.41e-041807549e09b3dfe344b5d50520711513d389865d73a861
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4-Exc_L4-5_RORB_RPL31P31|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PRUNE2 ABCA4 DPP10 CADPS2

2.41e-04180754b7513b9816a9cb9f3caaddb2a9fed0be1c7f9805
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PRUNE2 ABCA4 DPP10 CADPS2

2.41e-04180754f96c5be4705e3d338c0393d2885ac8d5beccd6fd
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

SECISBP2L UNC13B MTUS1 CADPS2

2.41e-04180754198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

DPP10 PTPRN2 MGAT4C UNC13A

2.52e-0418275457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

2.52e-0418275417ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCelldroplet-Lung-30m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ABCA4 ZBTB10 BEND3 CADPS2

2.57e-041837546f8f997ffc9eaebca2683de125b6069d07c07d26
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

MTUS1 PTPRN2 SIPA1L1 TRRAP

2.57e-04183754807d64deaf4e50dccf6f831f88578a6d903c1421
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-6|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

GGA2 CIITA SETBP1 DNAH8

2.57e-0418375482fe14fc7039415de41bdfd615a1380bed99f560
ToppCellLPS_only-Epithelial_alveolar-AT_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

2.57e-04183754e972432dd4d1bd31bb0982f4df3061e5e152658f
ToppCellLPS_only-Epithelial_alveolar-AT_1-Differentiating_AT1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FSD1L PAXBP1 MTUS1 CADPS2

2.62e-0418475442ce855b4f8475a8298192feec785bdc69bc5bb0
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

2.62e-04184754d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

SECISBP2L MTUS1 PLCL1 CADPS2

2.62e-04184754102105ae1a5ef6d42a43f6d9b00f12ed0690ddb7
ToppCellCOVID-19_Severe-gd_T|COVID-19_Severe / Disease condition and Cell class

FLNA DIP2A HLA-A ENPP4

2.62e-04184754791f1bcb954aadc63d4117c400537d036f68734d
ToppCellControl-Epithelial_alveolar-AT_2-Differentiating_AT2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SECISBP2L PAXBP1 MTUS1 CADPS2

2.68e-041857540d2add28ac1f4fa6de7699be009bf8391badaf4c
ToppCellCOVID-19-Epithelial_cells-Airway_club|COVID-19 / group, cell type (main and fine annotations)

UNC13B DPP10 MTUS1 CADPS2

2.68e-04185754cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

HLA-A CIITA MCM9 ENPP4

2.68e-04185754a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell343B-Lymphocytic-CD4_T-cell-Treg_cell_1|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

MTUS1 PTPRN2 SIPA1L1 TRRAP

2.73e-0418675476cbc3610aedf8c19c17ad5faf6ef5e8980b6af5
ToppCellLPS_only-Epithelial_alveolar|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

2.73e-04186754e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

SECISBP2L UNC13B MTUS1 CADPS2

2.73e-041867542ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_1-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

OMA1 FSD1L MTUS1 CADPS2

2.73e-041867544e94158db52df41d71e67b02b9895a358eebee0f
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

DPP10 MTUS1 CPEB4 PLCL1

2.73e-04186754a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCellSmart-seq2-blood_(Smart-seq2)-myeloid-myeloid_monocytic-classical_monocyte|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

CPEB4 PLEC DNAH8 JMJD1C

2.73e-0418675423b8d51d20b05795a73892d3e20e0f9b6a207820
ToppCellBL-critical-LOC-Lymphoid-B_cell|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

GGA2 CIITA SETBP1 DNAH8

2.73e-0418675427d4c38b180e4ce2bf3e7c4ad3db3a2ffca05ca8
Drugepirubicinol

GUSB C2 PLCL1

1.82e-068743CID000128975
Drugotavite

GUSB C2

1.04e-052742CID000010564
Drugmebeverine-alcohol

GUSB C2

1.04e-052742CID000026649
Drug0JO

ABCA4 C2

1.04e-052742CID015942668
DrugScaeg

GUSB C2

1.04e-052742CID000063010
DiseaseCharcot-Marie-Tooth disease type 2A2A (implicated_via_orthology)

MFN2 MFN1

5.87e-062722DOID:0110155 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease type 2A2B (implicated_via_orthology)

MFN2 MFN1

5.87e-062722DOID:0111557 (implicated_via_orthology)
DiseaseCharcot-Marie-Tooth disease (implicated_via_orthology)

MFN2 MTMR1 MFN1

2.72e-0524723DOID:10595 (implicated_via_orthology)
Diseaseatrophic macular degeneration

C2 PLCL1 NLRP5

3.08e-0525723EFO_1001492
DiseaseCharcot-Marie-Tooth disease type 2 (implicated_via_orthology)

MFN2 MFN1

3.51e-054722DOID:0050539 (implicated_via_orthology)
DiseasePeriventricular Nodular Heterotopia

FLNA TMTC3

1.22e-047722C1868720
Diseasemitochondrial DNA measurement

COPB1 MFN2 C2 MGAT4C JMJD1C MFN1

1.52e-04328726EFO_0006312
Diseaseprimary pulmonary hypertension (is_marker_for)

MFN2 MFN1

1.63e-048722DOID:14557 (is_marker_for)
DiseaseColorectal Carcinoma

UNC13B OMA1 ABCA4 PTPRN2 SETBP1 DIP2C DNAH8 MFN1

3.09e-04702728C0009402
DiseaseParanoia

HLA-A DNAH8

3.18e-0411722C1456784
DiseaseAutistic Disorder

FBXO40 HLA-A CADPS2 TRRAP JMJD1C

4.50e-04261725C0004352
Diseasesmoking status measurement

OMA1 DPP10 PTPRN2 PRELID2 SETBP1 CPEB4 PLCL1 CADPS2 DNAH8 ICA1L

4.97e-0411607210EFO_0006527
Diseasecoronary artery disease

ENAM OMA1 DPP10 C2 FGD5 PLCL1 INO80 ICA1L FCHO1 UNC13A

6.22e-0411947210EFO_0001645
Diseasemean reticulocyte volume

DIP2A TMTC3 HLA-A SMCO1 BEND3 ENPP4 TRRAP JMJD1C

7.25e-04799728EFO_0010701
Diseasemean platelet volume

OTP SETBP1 MCM9 CPEB4 ZBTB10 MTMR1 PLEC ICA1L JMJD1C

8.22e-041020729EFO_0004584
DiseaseAge-related macular degeneration

ABCA4 C2

8.76e-0418722cv:C0242383
Diseasebody weight

SECISBP2L UNC13B IPO9 COPB1 GUSB SETBP1 CPEB4 ST3GAL1 PLCL1 CADPS2

9.44e-0412617210EFO_0004338
Diseaseneuroimaging measurement

SECISBP2L OMA1 CPEB4 BEND3 PLCL1 PLEC ICA1L JMJD1C DNAH11

1.14e-031069729EFO_0004346
Diseasered blood cell density measurement

TMTC3 CIITA CPEB4 FGD5 SSR1 INO80 PLEC JMJD1C

1.35e-03880728EFO_0007978
DiseaseIschemic stroke, coronary artery disease

ENAM CADPS2 NLRP5

1.50e-0392723EFO_0001645, HP_0002140
Diseasemosquito bite reaction size measurement

CPEB4 C2 PLCL1 PLEC

1.82e-03212724EFO_0008378
Diseaseelectrocardiography

OMA1 SIPA1L1 SETBP1 PLCL1 PLEC JMJD1C

1.87e-03530726EFO_0004327
Diseasemacular degeneration (is_implicated_in)

ABCA4 C2

1.98e-0327722DOID:4448 (is_implicated_in)
DiseaseWeight Gain

SIPA1L1 SETBP1 DNAH11

2.01e-03102723C0043094
Diseasesodium measurement

SLC16A6 PLCL1 JMJD1C

2.07e-03103723EFO_0009282
DiseaseS-6-hydroxywarfarin measurement

ABCA4 DPP10 DIP2C PLCL1 FCHO1

2.07e-03368725EFO_0803326
DiseaseDrug-Induced Stevens Johnson Syndrome

HLA-A VCP

2.28e-0329722C1274933
DiseaseToxic Epidermal Necrolysis

HLA-A VCP

2.28e-0329722C0014518
DiseaseMycoplasma-Induced Stevens-Johnson Syndrome

HLA-A VCP

2.28e-0329722C3658301
DiseaseStevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum

HLA-A VCP

2.28e-0329722C3658302

Protein segments in the cluster

PeptideGeneStartEntry
SQPSWEQDFMFEINR

UNC13A

41

Q9UPW8
ASAFEPMNEWERNLA

NAIP

951

Q13075
PRESQADDMANFDWR

ABCA4

486

P78363
QEDQFPSADVRTWAM

CIITA

676

P33076
AAWNNEGLPSDRMST

DNAH11

3466

Q96DT5
SPQFTQTDAMDHRRW

CBLL2

376

Q8N7E2
WNPMEAFIFTAANED

DCAF13

246

Q9NV06
EMTSDTWLSQQNEEP

DPP10

361

Q8N608
DCVWQMTRQFPSAFE

MTMR1

506

Q13613
SDWNPTVDQQAMDRA

INO80

1196

Q9ULG1
NEDLRSWTAADMAAQ

HLA-H

151

P01893
ASSWSEEPVQSNMDI

PTPRN2

711

Q92932
NNRWDASASEPEYME

MFN1

236

Q8IWA4
FSRFWAQREMEDSQP

BEND3

336

Q5T5X7
SQSDPETKDFWLNMA

FCHO1

701

O14526
LADFNSSWRDAMVQD

MGAT4C

141

Q9UBM8
PSSRWESFWMNRENE

IFT122

186

Q9HBG6
ASSVNWNSANPDDMV

MTUS1

41

Q9ULD2
DNSVTVAWRMPEEDN

FSD1L

211

Q9BXM9
GNMSANASDQERTPW

C2

466

P06681
FTVSSNEMSWVRQAP

IGHV3-38-3

46

P0DTE1
SSSEQSLTEMWRPNN

JMJD1C

1266

Q15652
DPRNTDNAWMETEAV

NUDT9

271

Q9BW91
QPATCTDAEFRQMWA

COPB1

831

P53618
QENRSSAAAMWPGTD

ENPP4

126

Q9Y6X5
QMFGRLDTATNDWTD

DNAH8

2166

Q96JB1
TNSAQRWIEAMEDAS

FGD5

1446

Q6ZNL6
SSPATEQSWMENDFD

L1RE1

26

Q9UN81
NKATDPSMSEQDWSA

GGA2

31

Q9UJY4
PSMSEQDWSAIQNFC

GGA2

36

Q9UJY4
RSFENTAADWPEMQT

NLRP5

251

P59047
IAENMWDPFSTTQTS

PAXBP1

691

Q9Y5B6
LNNRWDASASEPEYM

MFN2

256

O95140
NWYSDADMPASARQE

ALPI

186

P09923
FRFPADAEWALNTMN

PABPC5

66

Q96DU9
WNLSDSDFVMDGSQP

CPEB2

421

Q7Z5Q1
PVTNAREAMQQADDW

FLNA

221

P21333
IWNFADFMTEQSPTR

GUSB

586

P08236
QRPDSTEEDSFQWMS

DIP2C

846

Q9Y2E4
DMDTALEAQPQDSWD

CADPS2

886

Q86UW7
EMSASDTRQRQEWTA

DEF6

291

Q9H4E7
NEDLRSWTAADMAAQ

HLA-A

151

P04439
SMEWNRWPNVDSETT

FBXO40

96

Q9UH90
QATPAEWSQDDSNDM

IPO9

936

Q96P70
APKSWMEDSLNRADN

CPEB4

356

Q17RY0
WNLSDSDFVMDGSQP

CPEB4

561

Q17RY0
RGNTWDERDDSPNTM

ENAM

616

Q9NRM1
QRPDASEEDSFQWMS

DIP2A

861

Q14689
SEEDSFQWMSRVLQA

DIP2A

866

Q14689
QDMSAWFNLFADLDP

ICA1L

451

Q8NDH6
NFEEIARDFNPNWMS

DDB1

941

Q16531
PNWMSAVEILDDDNF

DDB1

951

Q16531
WLQEQMSASSSREPS

PRSS56

331

P0CW18
SFHANDTRWAAAAMP

OTP

201

Q5XKR4
DLMDSFNESNSRISW

SLC16A6

51

O15403
NNRDDSLDWFDFMAT

MCM9

736

Q9NXL9
SSQNDVDMSWIPQET

SSR1

246

P43307
RSSFESPAQDQSWMF

PRUNE2

2621

Q8WUY3
WNFEQISFPNMASDS

TSEN54

296

Q7Z6J9
TPSWQRSEDSIADQM

SIPA1L1

1201

O43166
SAWFDERFNQTMQPL

ST3GAL1

71

Q11201
PGMDSEAWTADQQAS

SECISBP2L

1061

Q93073
QDPASWNETFAEMSR

SI

1566

P14410
RASSVFWQQMEFVDS

OMA1

411

Q96E52
TMRDSSNPRQNWNDV

CLEC4E

181

Q9ULY5
SEEDLSEATWMEQPN

NKAPL

256

Q5M9Q1
AMRIDSSNLNPQDFW

PLCL1

646

Q15111
AVTMDDFRWALSQSN

VCP

446

P55072
SWVVSDAPTEDDMAN

RNF141

201

Q8WVD5
MFQTAWRQEPVTFED

ZNF620

1

Q6ZNG0
VEADPANMFNWTTEE

TEX101

36

Q9BY14
KEESVFRESMENPNW

PRELID2

121

Q8N945
FRESMENPNWTEFIQ

PRELID2

126

Q8N945
DQPSWEQDFMFEISR

UNC13B

41

O14795
NDVDDFNWLARDMAS

TBCC

316

Q15814
ASQAAQDEMWTAVRA

SMCO1

51

Q147U7
EVGFDWSDRNTNMTA

PLEC

776

Q15149
MAQVDSQDRWGEASP

ZNF648

1

Q5T619
SSWVQDGSPEMAENE

ZBTB10

536

Q96DT7
LFQNDFWGTPMSEER

TMTC3

51

Q6ZXV5
FSEMNPSNDKWDSDV

SETBP1

1281

Q9Y6X0
EATLNDPQWSRMFMS

TRRAP

1576

Q9Y4A5