Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	MON2 GPRASP1 GBF1 NEK10 UBR4 RTTN ARFGEF2 ZYG11B ODAD2 HUWE1 ECPAS WDFY4 FMNL3 PPP4R3B PACRGL AP1G2 EIF3M ARMC8	6.55e-11	339	138	18	IPR016024
Domain	ARM-like	MON2 GPRASP1 RANGAP1 NEK10 RTTN ARFGEF2 ZYG11B ODAD2 HUWE1 ECPAS WDFY4 PPP4R3B PACRGL AP1G2 ARMC8	1.52e-09	270	138	15	IPR011989
Domain	-	MON2 GPRASP1 NEK10 RTTN ARFGEF2 ZYG11B ODAD2 ECPAS WDFY4 PACRGL AP1G2 ARMC8	9.65e-08	222	138	12	1.25.10.10
Domain	Sec7_N	MON2 GBF1 ARFGEF2	1.57e-06	4	138	3	IPR032691
Domain	Sec7_N	MON2 GBF1 ARFGEF2	1.57e-06	4	138	3	PF12783
Domain	-	LRRC39 RANGAP1 PRAMEF10 ZYG11B SHOC2 CNOT6L PXDN LGI2 PPP1R37 NLRC5 PHLPP1	2.70e-05	321	138	11	3.80.10.10
Domain	L_dom-like	LRRC39 RANGAP1 PRAMEF10 ZYG11B SHOC2 CNOT6L PXDN LGI2 PPP1R37 NLRC5 PHLPP1	3.28e-05	328	138	11	IPR032675
Domain	Leu-rich_rpt	LRRC39 RANGAP1 ZYG11B SHOC2 CNOT6L PXDN LGI2 PPP1R37 NLRC5 PHLPP1	3.39e-05	271	138	10	IPR001611
Domain	LRR	LRRC39 ZYG11B SHOC2 CNOT6L PXDN PPP1R37 NLRC5 PHLPP1	1.26e-04	201	138	8	PS51450
Domain	Adaptor_Cbl_EF_hand-like	CBL CBLB	1.62e-04	3	138	2	IPR014741
Domain	Adaptor_Cbl_SH2-like	CBL CBLB	1.62e-04	3	138	2	IPR014742
Domain	Adaptor_Cbl	CBL CBLB	1.62e-04	3	138	2	IPR024162
Domain	Cbl_PTB	CBL CBLB	1.62e-04	3	138	2	IPR024159
Domain	Cbl_N2	CBL CBLB	1.62e-04	3	138	2	PF02761
Domain	Cbl_N3	CBL CBLB	1.62e-04	3	138	2	PF02762
Domain	Cbl_N	CBL CBLB	1.62e-04	3	138	2	PF02262
Domain	Adaptor_Cbl_N_hlx	CBL CBLB	1.62e-04	3	138	2	IPR003153
Domain	CBL_PTB	CBL CBLB	1.62e-04	3	138	2	PS51506
Domain	-	CBL CBLB	1.62e-04	3	138	2	1.20.930.20
Domain	-	INTS6L ITGB8 INTS6 CACNA2D4 MDN1	2.19e-04	74	138	5	3.40.50.410
Domain	LRR_1	LRRC39 RANGAP1 SHOC2 CNOT6L PXDN LGI2 NLRC5 PHLPP1	2.26e-04	219	138	8	PF00560
Domain	Nebulin	NRAP NEBL	3.22e-04	4	138	2	PF00880
Domain	NEBULIN	NRAP NEBL	3.22e-04	4	138	2	PS51216
Domain	DCB_dom	MON2 ARFGEF2	3.22e-04	4	138	2	IPR032629
Domain	Sec7_C	MON2 ARFGEF2	3.22e-04	4	138	2	IPR015403
Domain	NEBU	NRAP NEBL	3.22e-04	4	138	2	SM00227
Domain	DUF1981	MON2 ARFGEF2	3.22e-04	4	138	2	PF09324
Domain	Nebulin	NRAP NEBL	3.22e-04	4	138	2	IPR013998
Domain	Nebulin_repeat	NRAP NEBL	3.22e-04	4	138	2	IPR000900
Domain	DCB	MON2 ARFGEF2	3.22e-04	4	138	2	PF16213
Domain	VWFA	INTS6L ITGB8 INTS6 CACNA2D4 MDN1	3.54e-04	82	138	5	PS50234
Domain	VWA	INTS6L ITGB8 INTS6 CACNA2D4 MDN1	3.96e-04	84	138	5	SM00327
Domain	VWA_2	INTS6L INTS6	5.34e-04	5	138	2	PF13519
Domain	LRR_6	RANGAP1 PPP1R37 NLRC5 PHLPP1	7.27e-04	55	138	4	PF13516
Domain	VWF_A	INTS6L ITGB8 INTS6 CACNA2D4 MDN1	8.40e-04	99	138	5	IPR002035
Domain	UBA	HUWE1 CBL CBLB	1.38e-03	30	138	3	SM00165
Domain	INT_SG_DDX_CT_C	INTS6L INTS6	1.47e-03	8	138	2	PF15300
Domain	INT_SG_DDX_CT_C	INTS6L INTS6	1.47e-03	8	138	2	IPR029307
Domain	LRR_8	LRRC39 SHOC2 CNOT6L PXDN LGI2 PHLPP1	1.71e-03	171	138	6	PF13855
Domain	LRR_TYP	LRRC39 SHOC2 CNOT6L PXDN LGI2 PHLPP1	2.04e-03	177	138	6	SM00369
Domain	Leu-rich_rpt_typical-subtyp	LRRC39 SHOC2 CNOT6L PXDN LGI2 PHLPP1	2.04e-03	177	138	6	IPR003591
Domain	Leu-rich_rpt_4	LRRC39 NLRC5	2.35e-03	10	138	2	IPR025875
Domain	LRR_4	LRRC39 NLRC5	2.35e-03	10	138	2	PF12799
Domain	UBA	HUWE1 CBL CBLB	2.36e-03	36	138	3	PF00627
Domain	VWFC_1	DGCR2 VWCE PXDN	2.36e-03	36	138	3	PS01208
Domain	VWFC_2	DGCR2 VWCE PXDN	2.76e-03	38	138	3	PS50184
Domain	VWC	DGCR2 VWCE PXDN	2.76e-03	38	138	3	SM00214
Domain	ARM_REPEAT	NEK10 ODAD2 ARMC8	3.19e-03	40	138	3	PS50176
Domain	VWF_dom	DGCR2 VWCE PXDN	3.67e-03	42	138	3	IPR001007
Domain	UBA	HUWE1 CBL CBLB	4.19e-03	44	138	3	IPR015940
Domain	ATPase_dyneun-rel_AAA	DNAH1 MDN1	4.65e-03	14	138	2	IPR011704
Domain	AAA_5	DNAH1 MDN1	4.65e-03	14	138	2	PF07728
Domain	UBA	HUWE1 CBL CBLB	5.05e-03	47	138	3	PS50030
Domain	-	GBF1 ARFGEF2	5.34e-03	15	138	2	1.10.1000.11
Domain	Sec7	GBF1 ARFGEF2	5.34e-03	15	138	2	PF01369
Domain	Sec7_alpha_orthog	GBF1 ARFGEF2	5.34e-03	15	138	2	IPR023394
Domain	SEC7	GBF1 ARFGEF2	6.08e-03	16	138	2	PS50190
Domain	Sec7	GBF1 ARFGEF2	6.08e-03	16	138	2	SM00222
Domain	Sec7_dom	GBF1 ARFGEF2	6.08e-03	16	138	2	IPR000904
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MON2 RANGAP1 IMPA2 COPA MAP1B UBR4 PACSIN3 HUWE1 ECPAS IFI16 ITPR3 MDN1 CNOT6L PXDN NUP155 COG6 ATAD3A CABIN1 DHX29 VPS53 EIF3M TRAPPC9 CDK4 PML ARMC8	9.03e-10	1440	142	25	30833792
Pubmed	DR5-Cbl-b/c-Cbl-TRAF2 complex inhibits TRAIL-induced apoptosis by promoting TRAF2-mediated polyubiquitination of caspase-8 in gastric cancer cells.	TRAF2 CBL CBLB	2.30e-06	7	142	3	28972304
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MON2 DGCR2 GBF1 UBR4 RTTN APBB3 ARFGEF2 TBC1D25 HUWE1 ITPR3 MDN1 NLRC5 AP1G2 STK40 CABIN1 PRRT4 TRAPPC9	2.93e-06	1105	142	17	35748872
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 TRAF2 COPA UBR4 BACH1 APBB3 ARFGEF2 HUWE1 BTBD1 NR1D1 ITGB8 BRWD3 WDR47 PPP4R3B FRY SGSM3 CABIN1 ARMC8	5.38e-06	1285	142	18	35914814
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	MON2 GBF1 ARL6IP5 ARFGEF2 RILP ITPR3 CDK5RAP3 NUP155 COG6 OSBPL11 GCC1	7.69e-06	504	142	11	34432599
Pubmed	CYLD Regulates Centriolar Satellites Proteostasis by Counteracting the E3 Ligase MIB1.	COPA MAP1B UBR4 HUWE1 ECPAS PXDN ATAD3A	1.05e-05	182	142	7	31067453
Pubmed	Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.	CBL CBLB	1.66e-05	2	142	2	25871390
Pubmed	Cbl-b is a negative regulator of inflammatory cytokines produced by IgE-activated mast cells.	CBL CBLB	1.66e-05	2	142	2	17056522
Pubmed	Thrombopoietin production in wild-type and interleukin-6 knockout mice with acute inflammation.	THPO IL6	1.66e-05	2	142	2	16022585
Pubmed	Association of a new c-Cbl related protein with the very first stages of apoptosis induction.	CBL CBLB	1.66e-05	2	142	2	12102152
Pubmed	Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury.	IL6 EPAS1	1.66e-05	2	142	2	33428604
Pubmed	Interleukin 6 signaling regulates promyelocytic leukemia protein gene expression in human normal and cancer cells.	IL6 PML	1.66e-05	2	142	2	22711534
Pubmed	PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation.	PIM1 IL6	1.66e-05	2	142	2	25040935
Pubmed	Cbl and Cbl-b control the germinal center reaction by facilitating naive B cell antigen processing.	CBL CBLB	1.66e-05	2	142	2	32584413
Pubmed	IL-6 deletion decreased REV-ERBα protein and influenced autophagy and mitochondrial markers in the skeletal muscle after acute exercise.	NR1D1 IL6	1.66e-05	2	142	2	36311768
Pubmed	The role of E3 ubiquitin ligase Cbl proteins in β-elemene reversing multi-drug resistance of human gastric adenocarcinoma cells.	CBL CBLB	1.66e-05	2	142	2	23665906
Pubmed	Inhibition of IL-6 trans-signaling in the brain increases sociability in the BTBR mouse model of autism.	ITPR3 IL6	1.66e-05	2	142	2	27460706
Pubmed	c-Cbl and Cbl-b regulate T cell responsiveness by promoting ligand-induced TCR down-modulation.	CBL CBLB	1.66e-05	2	142	2	12415267
Pubmed	Direct and indirect suppression of interleukin-6 gene expression in murine macrophages by nuclear orphan receptor REV-ERBα.	NR1D1 IL6	1.66e-05	2	142	2	25401152
Pubmed	NAMPT (visfatin), a direct target of hypoxia-inducible factor-2α, is an essential catabolic regulator of osteoarthritis.	IL6 EPAS1	1.66e-05	2	142	2	24347567
Pubmed	c-Cbl induced podocin ubiquitination contributes to the podocytes injury in diabetic nephropathy.	CBL NPHS2	1.66e-05	2	142	2	38752545
Pubmed	A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells.	CBL CBLB	1.66e-05	2	142	2	27276677
Pubmed	Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia.	CBL CBLB	1.66e-05	2	142	2	17475912
Pubmed	Fasudil, a clinically safe ROCK inhibitor, decreases disease burden in a Cbl/Cbl-b deficiency-driven murine model of myeloproliferative disorders.	CBL CBLB	1.66e-05	2	142	2	26177294
Pubmed	Thrombopoietin is not uniquely responsible for thrombocytosis in inflammatory disorders.	THPO IL6	1.66e-05	2	142	2	18041648
Pubmed	Loss of Cbl-PI3K interaction in mice prevents significant bone loss following ovariectomy.	CBL CBLB	1.66e-05	2	142	2	24994594
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	RANGAP1 GBF1 COPA BACH1 ARFGEF2 HUWE1 ECPAS IFI16 NR1D1 MDN1 OSBPL11 TIMELESS DHX29	1.86e-05	774	142	13	15302935
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ADCY4 RANGAP1 TRAF2 GBF1 COPA PITRM1 UBR4 CARS1 HUWE1 ECPAS MDN1 NUP155 ATAD3A PIM1 DHX29 EIF3M CDK4 ARMC8	2.16e-05	1425	142	18	30948266
Pubmed	Identifying the substrate proteins of U-box E3s E4B and CHIP by orthogonal ubiquitin transfer.	CBL CBLB CDK4	2.35e-05	14	142	3	29326975
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	GBF1 UBR4 ARFGEF2 HUWE1 MDN1 GOLPH3L VPS53 CDK4	2.58e-05	288	142	8	23383273
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	GBF1 COL16A1 MAP1B UBR4 PACSIN3 ZYG11B CBL ZSWIM9 CDK5RAP3 MDN1 SCAPER EIF3M	2.78e-05	689	142	12	36543142
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RANGAP1 TRAF2 COPA MAP1B UBR4 RPP38 HUWE1 IFI16 WDR47 MDN1 FBXL18 NUP155 ATAD3A PPP1R37 AP1G2 DHX29 EIF3M	3.97e-05	1353	142	17	29467282
Pubmed	Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.	TRAF2 UBR4 HUWE1 CBL CBLB	4.56e-05	95	142	5	29643511
Pubmed	Regulation of immune responses by E3 ubiquitin-protein ligases.	CBL CBLB	4.95e-05	3	142	2	11826757
Pubmed	Cbl-b regulates the CD28 dependence of T-cell activation.	CBL CBLB	4.95e-05	3	142	2	10646609
Pubmed	Cbl-b and c-Cbl negatively regulate osteoblast differentiation by enhancing ubiquitination and degradation of Osterix.	CBL CBLB	4.95e-05	3	142	2	25744063
Pubmed	Differential ubiquitin binding of the UBA domains from human c-Cbl and Cbl-b: NMR structural and biochemical insights.	CBL CBLB	4.95e-05	3	142	2	18596201
Pubmed	Inactivation of c-Cbl or Cbl-b differentially affects signaling from the high affinity IgE receptor.	CBL CBLB	4.95e-05	3	142	2	15265912
Pubmed	[Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].	CBL CBLB	4.95e-05	3	142	2	21645455
Pubmed	Ubiquitin Ligases CBL and CBL-B Maintain the Homeostasis and Immune Quiescence of Dendritic Cells.	CBL CBLB	4.95e-05	3	142	2	34630435
Pubmed	Dynamic Response of IFI16 and Promyelocytic Leukemia Nuclear Body Components to Herpes Simplex Virus 1 Infection.	IFI16 PML	4.95e-05	3	142	2	26468536
Pubmed	c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.	CBL CBLB	4.95e-05	3	142	2	21768087
Pubmed	Cbl-b interacts with ubiquitinated proteins; differential functions of the UBA domains of c-Cbl and Cbl-b.	CBL CBLB	4.95e-05	3	142	2	15273720
Pubmed	The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).	GBF1 ARFGEF2	4.95e-05	3	142	2	23386609
Pubmed	The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes.	CBL CBLB	4.95e-05	3	142	2	38170572
Pubmed	Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance.	CBL CBLB	4.95e-05	3	142	2	20038312
Pubmed	A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells.	CBL CBLB	4.95e-05	3	142	2	10074432
Pubmed	E3 ubiquitin ligases Cbl-b and c-Cbl downregulate PD-L1 in EGFR wild-type non-small cell lung cancer.	CBL CBLB	4.95e-05	3	142	2	29364514
Pubmed	Genetic map of the fused locus on mouse chromosome 17.	ITPR3 PIM1	4.95e-05	3	142	2	7829069
Pubmed	Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors.	CBL CBLB	4.95e-05	3	142	2	12874286
Pubmed	Unique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells.	CBL CBLB	4.95e-05	3	142	2	31282857
Pubmed	Soluble P-selectin, interleukin 6, and thrombopoietin levels in children with acute and chronic idiopathic thrombocytopenic purpura and their relationship with mega-dose methylprednisolone therapy: a pilot study.	THPO IL6	4.95e-05	3	142	2	12468916
Pubmed	T-cell receptor ligation causes Wiskott-Aldrich syndrome protein degradation and F-actin assembly downregulation.	CBL CBLB	4.95e-05	3	142	2	23684068
Pubmed	The ablation of the matricellular protein EMILIN2 causes defective vascularization due to impaired EGFR-dependent IL-8 production affecting tumor growth.	EMILIN2 IL6	4.95e-05	3	142	2	29483644
Pubmed	Circulating levels of thrombopoietic and inflammatory cytokines in patients with acute myeloblastic leukemia and myelodysplastic syndrome.	THPO IL6	4.95e-05	3	142	2	12187073
Pubmed	Cbl regulates the activity of SIRT2.	CBL CBLB	4.95e-05	3	142	2	25285640
Pubmed	VAV1-Cre mediated hematopoietic deletion of CBL and CBL-B leads to JMML-like aggressive early-neonatal myeloproliferative disease.	CBL CBLB	4.95e-05	3	142	2	27449297
Pubmed	Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes.	CBL CBLB	4.95e-05	3	142	2	37903221
Pubmed	Novel insights into the mechanisms of CIN85 SH3 domains binding to Cbl proteins: solution-based investigations and in vivo implications.	CBL CBLB	4.95e-05	3	142	2	19268472
Pubmed	Cbl negatively regulates JNK activation and cell death.	CBL CBLB	4.95e-05	3	142	2	19546888
Pubmed	The tyrosine phosphatase SHP-2 regulates differentiation and apoptosis of individual primary T lymphocytes.	CBL CBLB	4.95e-05	3	142	2	17330819
Pubmed	A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation.	CBL CBLB	4.95e-05	3	142	2	18316398
Pubmed	Regulation of stem cell factor receptor signaling by Cbl family proteins (Cbl-b/c-Cbl).	CBL CBLB	4.95e-05	3	142	2	15315962
Pubmed	Distinct functions for Arf guanine nucleotide exchange factors at the Golgi complex: GBF1 and BIGs are required for assembly and maintenance of the Golgi stack and trans-Golgi network, respectively.	GBF1 ARFGEF2	4.95e-05	3	142	2	18003980
Pubmed	The Ubiquitin Ligases c-Cbl and Cbl-b Negatively Regulate Platelet-derived Growth Factor (PDGF) BB-induced Chemotaxis by Affecting PDGF Receptor β (PDGFRβ) Internalization and Signaling.	CBL CBLB	4.95e-05	3	142	2	27048651
Pubmed	Cbl-b, a RING-type E3 ubiquitin ligase, targets phosphatidylinositol 3-kinase for ubiquitination in T cells.	CBL CBLB	4.95e-05	3	142	2	11087752
Pubmed	Phospho-tyrosine dependent protein-protein interaction network.	LETMD1 APBB3 PACSIN3 HUWE1 CBL CBLB C9orf43 PACRGL SCAPER	5.06e-05	410	142	9	25814554
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PRAMEF33 TRAF2 GBF1 PRAMEF10 NEBL PITRM1 PACSIN3 WDR47 MDN1 COG6 ATAD3A GYS2 TIMELESS VPS53 TRAPPC9 GPRC5B	5.07e-05	1242	142	16	30973865
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	THNSL1 GBF1 NRAP NEBL PITRM1 RPP38 CPN1 ODAD2 WDFY4	5.56e-05	415	142	9	16385451
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	GPRASP1 RANGAP1 THNSL1 COPA MAP1B ZYG11B HUWE1 BTBD1 NUP155 FARS2 OSBPL11 PHLPP1 EIF3M ARMC8	6.75e-05	1005	142	14	19615732
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	MON2 RANGAP1 GBF1 COPA MAP1B ARL6IP5 UBR4 HUWE1 ECPAS ATAD3A EIF3M	8.59e-05	657	142	11	36180527
Pubmed	IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.	CBL CBLB	9.88e-05	4	142	2	29237719
Pubmed	PML regulates apoptosis at endoplasmic reticulum by modulating calcium release.	ITPR3 PML	9.88e-05	4	142	2	21030605
Pubmed	Evidence for direct interaction between Sprouty and Cbl.	CBL CBLB	9.88e-05	4	142	2	11053437
Pubmed	PML suppresses IL-6-induced STAT3 activation by interfering with STAT3 and HDAC3 interaction.	IL6 PML	9.88e-05	4	142	2	25892518
Pubmed	An essential role of CBL and CBL-B ubiquitin ligases in mammary stem cell maintenance.	CBL CBLB	9.88e-05	4	142	2	28100467
Pubmed	Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.	CBL CBLB	9.88e-05	4	142	2	19815501
Pubmed	Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.	CBL CBLB	9.88e-05	4	142	2	20951942
Pubmed	TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation.	UBR4 HUWE1	9.88e-05	4	142	2	37324936
Pubmed	H19 non coding RNA-derived miR-675 enhances tumorigenesis and metastasis of breast cancer cells by downregulating c-Cbl and Cbl-b.	CBL CBLB	9.88e-05	4	142	2	26353930
Pubmed	The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins.	CBL CBLB	9.88e-05	4	142	2	12935897
Pubmed	Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells.	CBL CBLB	9.88e-05	4	142	2	20805496
Pubmed	Synergism of cytoplasmic kinases in IL6-induced ligand-independent activation of androgen receptor in prostate cancer cells.	PIM1 IL6	9.88e-05	4	142	2	14981536
Pubmed	Hypoxia antagonizes glucose deprivation on interleukin 6 expression in an Akt dependent, but HIF-1/2α independent manner.	IL6 EPAS1	9.88e-05	4	142	2	23520526
Pubmed	Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9.	RANGAP1 PML	9.88e-05	4	142	2	29773808
Pubmed	Int6/eIF3e silenced HIF2α stabilization enhances migration and tube formation of HUVECs via IL-6 and IL-8 signaling.	IL6 EPAS1	9.88e-05	4	142	2	23478175
Pubmed	Gene trap expression and mutational analysis for genes involved in the development of the mammalian nervous system.	MAP1B RTTN	9.88e-05	4	142	2	9626495
Pubmed	CD2-Associated Protein Contributes to Hepatitis C, Virus Propagation and Steatosis by Disrupting Insulin Signaling.	CBL CBLB	9.88e-05	4	142	2	29729186
Pubmed	The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes.	NR1D1 IL6	9.88e-05	4	142	2	19955433
Pubmed	Cbl promotes clustering of endocytic adaptor proteins.	CBL CBLB	9.88e-05	4	142	2	16228008
Pubmed	SUMO-1 protease-1 regulates gene transcription through PML.	RANGAP1 PML	9.88e-05	4	142	2	12419228
Pubmed	E3 ligases Arf-bp1 and Pam mediate lithium-stimulated degradation of the circadian heme receptor Rev-erb alpha.	HUWE1 NR1D1	9.88e-05	4	142	2	20534529
Pubmed	HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.	HUWE1 SHOC2	9.88e-05	4	142	2	25022756
Pubmed	Cloning of the murine homolog of the leukemia-associated PML gene.	CBL PML	9.88e-05	4	142	2	8563172
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	MON2 RANGAP1 COPA ECPAS PCYOX1L INTS6 CDK5RAP3 NUP155 COG6 TIMELESS	1.08e-04	560	142	10	35241646
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	MON2 RANGAP1 GBF1 COG6 AP1G2 ARMC8	1.11e-04	183	142	6	23956138
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	RANGAP1 COPA UBR4 HUWE1 BTBD1 ECPAS ITPR3 PXDN NUP155 ATAD3A TIMELESS VPS53 CDK4	1.36e-04	942	142	13	31073040
Pubmed	K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.	COPA UBR4 HUWE1 ATAD3A	1.49e-04	65	142	4	29378950
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	COPA UBR4 PACSIN3 SHOC2 INTS6 FRY NUP155 DHX29 TRAPPC9	1.54e-04	475	142	9	31040226
Pubmed	Atypical polyproline recognition by the CMS N-terminal Src homology 3 domain.	CBL CBLB	1.64e-04	5	142	2	17020880
Coexpression	GSE41867_DAY6_VS_DAY8_LCMV_CLONE13_EFFECTOR_CD8_TCELL_DN	LETMD1 HUWE1 CBL FMNL3 PCYOX1L INTS6 MDN1 SCAPER SGSM3	1.28e-06	200	139	9	M9486
Coexpression	GSE45365_NK_CELL_VS_BCELL_UP	MON2 BACH1 CBL PACRGL MDN1 SOCS5 GCC1 IL6	1.11e-05	198	139	8	M10031
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL MAP1B PPFIA4 CBLB FRY NPHS2 SNX25	1.65e-06	177	142	7	4d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL MAP1B PPFIA4 CBLB FRY NPHS2 SNX25	1.71e-06	178	142	7	edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB ITGB8 FRY NPHS2 SNX25	2.06e-06	183	142	7	7c4b775f351794a3de06bd503eecbc8ae8577c44
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB ITGB8 FRY NPHS2 SNX25	2.21e-06	185	142	7	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MON2 GBF1 ARFGEF2 HUWE1 ANKRD36C CBLB NUP155	2.73e-06	191	142	7	9454f642c3621370fa23640b631301346b300950
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_ciliated-Deuterosomal\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	TLCD3B NRAP NEBL NEK10 DNAH1 GYS2 CFAP161	3.35e-06	197	142	7	6e4a411ef823ce9e16f420e185e21fa19d13af34
ToppCell	PND01-03-samps-Mesenchymal-Myofibroblast-myofibroblast_-_mature_-_DCN\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	COL16A1 IMPA2 THSD7B DNAH1 LGI2 SERPIND1	5.20e-06	137	142	6	a69976938d4e89315ec0be3a332b91ddf3799d65
ToppCell	droplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF366 CYP8B1 PPFIA4 WDFY4 DNAH1 TIMELESS	1.61e-05	167	142	6	f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCell	TCGA-Colorectal-Recurrent_Tumor\|TCGA-Colorectal / Sample_Type by Project: Shred V9	PRAMEF33 PRAMEF10 CYP8B1 ETNPPL ORM2 GYS2	2.10e-05	175	142	6	7f74961436f88c0e380819095e6104489914d765
ToppCell	TCGA-Colorectal-Recurrent_Tumor-Colorectal_Adenocarcinoma\|TCGA-Colorectal / Sample_Type by Project: Shred V9	PRAMEF33 PRAMEF10 CYP8B1 ETNPPL ORM2 GYS2	2.10e-05	175	142	6	bee8f31f036dfcf9fc6ed29156554771a9ee3c60
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB ITGB8 FRY NPHS2	2.38e-05	179	142	6	7394e77e665bf16d3733df91bb12907be460ab44
ToppCell	3'-Adult-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OR7D4 ADCY4 ZNF366 IFI16 MAP3K6 GPRC5B	2.46e-05	180	142	6	efc4c5a4dea456527526bbfd88cf70d803893671
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.54e-05	181	142	6	5bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.54e-05	181	142	6	8e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 ZNF366 IFI16 MAP3K6 FMNL3 EPAS1	2.70e-05	183	142	6	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	NEBL MAP1B PPFIA4 CBLB FRY NPHS2	2.70e-05	183	142	6	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.70e-05	183	142	6	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	Calu_3-infected\|Calu_3 / Cell line, Condition and Strain	SAMD9 IFI16 ITGB8 NLRC5 IL6 PML	2.70e-05	183	142	6	8f7f5000645f24f20a8d7700c4df1f8953a1780b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.70e-05	183	142	6	612d93df03252d4d2ccdce5a9bc162cfd9172a1a
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.70e-05	183	142	6	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.70e-05	183	142	6	eb559ae3ae252d9365c24ef557dd49b78ed6d898
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.70e-05	183	142	6	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.78e-05	184	142	6	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.87e-05	185	142	6	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL PPFIA4 CBLB FRY NPHS2 SNX25	2.87e-05	185	142	6	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COPA MAP1B BACH1 HUWE1 STK40 IL6	2.87e-05	185	142	6	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	MON2 GBF1 HUWE1 ANKRD36C CBLB NUP155	2.96e-05	186	142	6	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_vein\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADCY4 ZNF366 MAP3K6 ABCC8 CFAP161 EPAS1	3.05e-05	187	142	6	e35716f8b482be3bf5ab79f087a9caf67a9d197a
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL MAP1B PPFIA4 ITGB8 FRY NPHS2	3.05e-05	187	142	6	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Degenerative_Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL MAP1B PPFIA4 ITGB8 FRY NPHS2	3.53e-05	192	142	6	ef0aba777072429a6ab7dcfcc305673975946580
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	NEBL MAP1B PPFIA4 ITGB8 FRY NPHS2	3.64e-05	193	142	6	3eaa0461618582a1754400624350d269d24e750a
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADCY4 ZNF366 IFI16 PXDN CFAP161 EPAS1	3.64e-05	193	142	6	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	CBLB WDFY4 MDN1 CNOT6L FARS2 SNX25	3.64e-05	193	142	6	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UBR4 VWCE ITGB8 PXDN UGT2A3 DIXDC1	3.74e-05	194	142	6	70185c0b8e0f4e896645b17a243482ba3cdf4a5d
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NEBL ABCA13 PPFIA4 THSD7B PKD1L3 ABCC8	3.85e-05	195	142	6	d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCell	Smart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic\|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	NEBL ABCA13 PPFIA4 THSD7B PKD1L3 ABCC8	3.85e-05	195	142	6	19853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ZNF366 FMNL3 PHLPP1 CFAP161 EPAS1	4.08e-05	197	142	6	cd509e49bbdbf991cc5913960ff3ef275ad40628
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GPRASP1 NEK10 RTTN ANKRD36C CBLB NLRC5	4.08e-05	197	142	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADCY4 ZNF366 FMNL3 PHLPP1 CFAP161 EPAS1	4.08e-05	197	142	6	412cb5f37df57121ddd1492021445479c7cbccbf
ToppCell	Mild-CD8+_T_activated\|Mild / Disease group and Cell class	SAMD9 IFI16 CBLB PIM1 NLRC5 PML	4.19e-05	198	142	6	ceac1b51bacfd0dd7fe7c6a666f7927055e1f380
ToppCell	LPS_anti-TNF-Epithelial_airway-airway_epithelial-Ciliated\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	NEK10 ANKMY1 ODAD2 DNAH1 PCYOX1L CFAP161	4.31e-05	199	142	6	15f7814b7074170eee7ccacaa670b1d128fc68bb
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Intermediate\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	PPFIA4 ARFGEF2 CACNA2D4 NLRC5 CABIN1 CARD14	4.31e-05	199	142	6	cf592d93612023a13de21e0fb8c6b13714f9af71
ToppCell	(01)_IL1RL1+-(2)_GFP_FOXI1\|(01)_IL1RL1+ / shred by cell type by condition	SAMD9 ARL6IP5 RPP38 PXDN DHX29 EIF3M	4.31e-05	199	142	6	a2f7d0cabf35b80fe239fae34a77bf9344d5d743
Drug	Metergoline [17692-51-2]; Up 200; 10uM; MCF7; HT_HG-U133A	MON2 DGCR2 GBF1 COPZ2 MAP1B CBLB PIM1 SCAPER TIMELESS VPS53 PML	3.09e-08	191	141	11	5344_UP
Disease	anxiety disorder, environmental factor	ECPAS SHOC2	1.93e-05	2	130	2	EFO_0000469, EFO_0006788
Disease	TYPE 1 DIABETES MELLITUS	ITPR3 IL6	1.15e-04	4	130	2	222100
Disease	Diabetes mellitus type 1	ITPR3 IL6	1.15e-04	4	130	2	cv:C0011854
Disease	response to placebo	THPO PXDN	1.91e-04	5	130	2	EFO_0008344
Disease	periventricular nodular heterotopia (is_implicated_in)	MAP1B ARFGEF2	2.86e-04	6	130	2	DOID:0050454 (is_implicated_in)
Disease	Depressive disorder	OR7D4 IMPA2 NR1D1 ALG8 TIMELESS DIXDC1 IL6	3.04e-04	289	130	7	C0011581
Disease	Neoplastic Cell Transformation	ARL6IP5 PIM1 PHLPP1 IL6 EPAS1	3.85e-04	139	130	5	C0007621
Disease	Periventricular Nodular Heterotopia	MAP1B ARFGEF2	3.99e-04	7	130	2	C1868720
Disease	glypican-1 measurement	NRAP ANKMY1	3.99e-04	7	130	2	EFO_0801649
Disease	pack-years measurement, systolic blood pressure	FRY CACNA2D4 TRAPPC9	4.52e-04	34	130	3	EFO_0006335, EFO_0006526
Disease	JT interval	GBF1 BACH1 FMNL3 PXDN ABCC8 EPAS1	8.31e-04	248	130	6	EFO_0007885
Disease	Intellectual Disability	PITRM1 MAP1B RTTN BRWD3 LINS1 FRY SCAPER VPS53	8.47e-04	447	130	8	C3714756
Disease	Diabetes, Autoimmune	ITPR3 ABCC8 IL6	9.70e-04	44	130	3	C0205734
Disease	Brittle diabetes	ITPR3 ABCC8 IL6	9.70e-04	44	130	3	C0342302
Disease	Diabetes Mellitus, Sudden-Onset	ITPR3 ABCC8 IL6	9.70e-04	44	130	3	C4554117
Disease	Diabetes Mellitus, Ketosis-Prone	ITPR3 ABCC8 IL6	9.70e-04	44	130	3	C3837958
Disease	autosomal dominant nonsyndromic deafness (is_implicated_in)	MAP1B ELMOD3	1.03e-03	11	130	2	DOID:0050564 (is_implicated_in)
Disease	Diabetes Mellitus, Insulin-Dependent	ITPR3 ABCC8 IL6	1.04e-03	45	130	3	C0011854
Disease	hyperinsulinism (is_implicated_in)	ABCC8 IL6	1.24e-03	12	130	2	DOID:2018 (is_implicated_in)
Disease	ocular hypertension, response to triamcinolone acetonide	GDPD1 BACH1 TIMELESS	1.33e-03	49	130	3	EFO_0006954, EFO_1001069
Disease	asthma, body mass index	COL16A1 ITGB8	1.69e-03	14	130	2	EFO_0004340, MONDO_0004979
Disease	RASopathy	CBL SHOC2	1.95e-03	15	130	2	cv:C5555857
Disease	QRS duration	NRBF2 NEBL UBR4 FMNL3 CACNA2D4 EPAS1	2.11e-03	298	130	6	EFO_0005055
Disease	neutrophil collagenase measurement	ABCA13 CPN1	2.22e-03	16	130	2	EFO_0008248
Disease	vision disorder	THPO PXDN	2.22e-03	16	130	2	MONDO_0021084
Disease	serum IgG glycosylation measurement	MON2 ERICH1 NRBF2 FRY THPO PXDN EPAS1 GPRC5B	2.28e-03	523	130	8	EFO_0005193
Disease	lung non-small cell carcinoma (is_implicated_in)	CBL CBLB EPAS1 CDK4	3.39e-03	139	130	4	DOID:3908 (is_implicated_in)
Disease	neutrophil percentage of granulocytes	TLCD3B CYP8B1 ITGB8 COG6 IL6	3.45e-03	228	130	5	EFO_0007994
Disease	hyperglycemia (biomarker_via_orthology)	CBL EPAS1	3.83e-03	21	130	2	DOID:4195 (biomarker_via_orthology)
Disease	eosinophil percentage of granulocytes	TLCD3B CYP8B1 ITGB8 COG6 IL6	3.86e-03	234	130	5	EFO_0007996

Protein segments in the cluster

Peptide	Gene	Start	Entry
MNALKDLLRHTRGLS	PRAMEF33	391	A0A0G2JMD5
VSILYHMKTLLLLQD	ERICH1	386	Q86X53
IMRLAISFLRTHKLL	EPAS1	56	Q99814
LSRNDFQSLLKMHKL	BACH1	536	O14867
LALLHLLYLVMDSKT	ELMOD3	216	Q96FG2
FNLIHRLSLMKTSAI	COL16A1	51	Q07092
SKLKMRLEALSLLHT	ATAD3A	91	Q9NVI7
VLTCLFESLNHMLRK	COPZ2	126	Q9P299
NLKSIMRLVLALAAH	DIXDC1	111	Q155Q3
LSRLNFLLRMHKSDI	GYS2	346	P54840
VAHLLFLRDTKTLMF	ORM2	116	P19652
LAIFLTLLSNFKMHL	ARFGEF2	456	Q9Y6D5
VLALLEKVLQSHMSL	AP1G2	506	O75843
MKDLTQDFRIRHLLS	ABCA13	2066	Q86UQ4
MLRLSALFESHIKNI	BRWD3	1416	Q6RI45
SCSLFLHMSFELKLL	ADCY4	731	Q8NFM4
DNKMLYLSSDHRTLL	CFAP161	156	Q6P656
SFLNRLGKLLLHLFM	DPY19L3	336	Q6ZPD9
ILQKRSDLHLILMSA	DHX29	721	Q7Z478
LALMAHTILFLKLFS	DGAT1	196	O75907
LKQMELLNTNSRFLH	ETNPPL	71	Q8TBG4
TFLTRLLVHMGLLKS	RANGAP1	511	P46060
LLLVNAELRHKLAAM	RILP	151	Q96NA2
LDQLTRMRSNLLKTH	INTS6L	521	Q5JSJ4
NLLDHLTRMRSNLLK	INTS6	551	Q9UL03
ASKLLLALMESRHDS	ITPR3	1996	Q14573
MKHSLNALLIFLIIT	SERPIND1	1	P05546
RFEKILQHSSLMLQV	ANKRD36C	1761	Q5JPF3
SLRKHLDLISQMIIR	MDN1	3796	Q9NU22
QRFMSELLTFLKPHL	LINS1	411	Q8NG48
LMITDAARHKLLVLT	MAP1B	126	P46821
ALHVKALSRAMLLTS	LETMD1	251	Q6P1Q0
RLLHSLQIAKMSSEV	NRAP	601	Q86VF7
HRLKLRLAIQEMVSL	PPFIA4	881	O75335
LRLQLLSNLFHGMDK	EIF3M	101	Q7L2H7
ELSNLLKLTHLDLSM	LRRC39	171	Q96DD0
RNLTKLSLIFSHMLA	CBLB	141	Q13191
LSSRMPHLFTKDIAL	ECPAS	426	Q5VYK3
LSLLHQESKRRAMLA	MAP3K6	991	O95382
SLSLHMQDFVKLLGL	PCYOX1L	86	Q8NBM8
LMILHEYDLLSKRLT	NEK10	256	Q6ZWH5
LSILAAILMETKLHS	OR3A4P	46	P47883
FLVQTTMKRLLAHRS	NPHS2	216	Q9NP85
TMKRLLAHRSLTEIL	NPHS2	221	Q9NP85
DLLLMRKALFDHLTA	GDPD1	256	Q8N9F7
LSAEAQSLLRMLFKR	RPS6KA6	296	Q9UK32
MALSVLLKRSQDVLH	MON2	1606	Q7Z3U7
MLVHLLSSRKTISFA	OR13J1	81	Q8NGT2
LLRRVLVLMNSKHTF	PPP4R3B	571	Q5MIZ7
ESFEKLRHMLLLAIQ	HUWE1	4351	Q7Z6Z7
ATLKLFLSNMERLLH	IMPA2	181	O14732
SLELQRDSHMKQLLL	NRBF2	56	Q96F24
MLKRLDLSHLLLNSS	NLRC5	1551	Q86WI3
VLLSAQGSLMFHKLR	NUP155	501	O75694
LMALSLALKVNHSLL	PPP1R37	406	O75864
ERKMRAHQVLTFLLL	GPRC5B	6	Q9NZH0
SLVHILLMKRLTFST	OR7D4	156	Q8NG98
AKRLLLVMTDQTSHL	ITGB8	276	P26012
RTLNNMHSEKLLSFR	NR1D1	596	P20393
SLFLAMFQSRHAKDL	NPAS4	211	Q8IUM7
MHLLSKKIFFNSLSL	COG6	406	Q9Y2V7
VMEFKSLLLSLCLFH	DNAH1	3811	Q9P2D7
SFLDAFRLKPSLLHM	APBB3	471	O95704
LFRLLSDSDLNVLMK	ARMC8	516	Q8IUR7
SDHALMLRELQKLLQ	GCC1	241	Q96CN9
LRDHSTLLKVSSMLQ	CABIN1	1616	Q9Y6J0
VLRLKDEMLSLSLHY	CARD14	191	Q9BXL6
MSDLLSVFLHLLLLF	CPN1	1	P15169
LLLEMLTFNPHKRIS	CDK4	271	P11802
HRKLSQLEAMIRFLT	CACNA2D4	696	Q7Z3S7
FAVLDRMHSLLIKNL	COPA	426	P53621
STDRKMTLLHFIALT	FMNL3	801	Q8IVF7
LTKHLRADNAFMLLT	BTBD1	171	Q9H0C5
SSKMFLSIHRLTLER	C9orf43	256	Q8TAL5
KLTSLQLQHLFMILA	CDK5RAP3	411	Q96JB5
AEMKVVLALTLLHFR	CYP4F11	476	Q9HBI6
QRMDKRTLALLVLAH	GOLPH3L	216	Q9H4A5
NMDSKLALIDRLISH	ANKMY1	746	Q9P2S6
SSFLILSLLLFMVHR	DGCR2	356	P98153
HFRMVKSLLSNDLKL	IFI16	21	Q16666
RMRASTLLSKVFLQH	GBF1	1616	Q92538
LTKLSLIFSHMLAEL	CBL	151	P22681
VRDSLHLLKSLNDTM	EMILIN2	576	Q9BXX0
DMHHTLLDSSLKLLL	FRY	676	Q5TBA9
LLNMSRELSDLKKHL	FRY	2861	Q5TBA9
FSNLMSQDIALLKLR	PRSS46P	121	E5RG02
SNKITFLMDLLIHQL	SCAPER	1011	Q9BY12
KLFILLMVTHFDLEL	CYP8B1	451	Q9UNU6
MRQRIFHLLKGTSLN	FPGT	346	O14772
LQDMTTHLILRSFKE	IL6	186	P05231
IRLNSKLHTIMCFFL	OR5D13	51	Q8NGL4
RQRLLFFKDMLLTLH	PACSIN3	236	Q9UKS6
HLKHLLTSLSKRLMD	PACRGL	196	Q8N7B6
LHLLSQLKLGMDLTR	OSBPL11	371	Q9BXB4
LHSLFRVLLMSRLSF	OR1L6	191	Q8NGR2
MLLSKINSLAHLRAA	PIM1	1	P11309
KTRFHVLKMLLNLSE	GPRASP1	1291	Q5JY77
THLFNLLAMLLRKAG	RTTN	1741	Q86VV8
AHIKALLALLSFAML	TAS2R60	241	P59551
GKMLLHTEYSLLSLL	STK40	86	Q8N2I9
LKKHSARQLRLAFLM	CARS1	421	P49589
MHFILQTLEDRLKAI	RPP38	41	P78345
RAMATKFAHLKLLLR	TBC1D25	371	Q3MII6
LFSNKRKIHLSELML	SOCS5	201	O75159
IKDRMFSHLPSLQLL	LGI2	76	Q8N0V4
TRANKHLLYALMELL	SNX25	806	Q9H3E2
KFLQDMHTLLLTRHR	SAMD9	1026	Q5K651
LLARLLKTSHENMLI	ODAD2	636	Q5T2S8
RLLALHNVSFMELLS	PML	796	P29590
LTSLRLSKMLSALQH	FBXL18	131	Q96ME1
LSKMLSALQHLRSLA	FBXL18	136	Q96ME1
LLMFIHASLRLRNLK	ARL6IP5	131	O75915
LARLMTAKFLHTEIR	PITRM1	886	Q5JRX3
LLSANRKLLQVHDLM	PKD1L3	491	Q7Z443
SRVLFQLTLGMLHLK	SGSM3	306	Q96HU1
NSMRLDLSKRSIHIL	SHOC2	101	Q9UQ13
DTHLLKLVAFMLSTL	OR6T1	191	Q8NGN1
LLSLLVFSQLLKHMV	ABCC8	1011	Q09428
GLMLLSIARLFQKRH	ALG8	171	Q9BVK2
RFLASRLSMKQHLDS	CLCNKB	346	P51801
TRKLLNFMLDNLAVH	CNOT6L	151	Q96LI5
REHLAMLLSSVLEAK	TRAF2	241	Q12933
RLAHDLKMEALLFQL	TIMELESS	731	Q9UNS1
FLNSKKLHISMLALE	WDR47	21	O94967
VRLLADVTHLLLKAM	ZYG11B	401	Q9C0D3
KAFMLRSVLTEHQRL	ZNF540	446	Q8NDQ6
RLALFFVKSSMHLAR	ZSWIM9	41	Q86XI8
HLELFLKMLRQVLVT	THAP9	611	Q9H5L6
LESMKRLRLDSNTLH	PXDN	181	Q92626
LHLLQLLLRTNLMKT	VWCE	796	Q96DN2
MAFLLRKKASLLNHR	WDFY4	1421	Q6ZS81
SMLSLNLGLNFKFHL	PRRT4	46	C9JH25
MNALKDLLRHTRGLS	PRAMEF10	391	O60809
ILKSSNLERHLHLMA	THNSL1	566	Q8IYQ7
LLLDTHSLKMVLLDL	VPS53	696	Q5VIR6
REFTLLANMKRHVLI	ZNF366	456	Q8N895
TLLHKVNGALMLLSF	TLCD3B	186	Q71RH2
MRSDKSALVFLLLQL	UGT2A3	1	Q6UWM9
LLMKADSLRFLNASA	PHLPP1	981	O60346
VRHLSFLLQTMLDFL	TRAPPC9	481	Q96Q05
SMRKLFLLLSLLLSH	THSD7B	16	Q9C0I4
FDLKQTLTRLMAHLF	FARS2	241	O95363
LNIHDIKLLFLRFAM	UBR4	4956	Q5T4S7
SFQHLLRGKVRFLML	THPO	151	P40225
LLFLDHVLKASKMLS	NEBL	286	O76041