Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	NPHP3 TMTC3 TTC21A TCF25 TTC34	2.71e-04	207	52	5	1.25.40.10
Domain	TPR	NPHP3 TMTC3 TTC21A TTC34	4.55e-04	129	52	4	SM00028
Domain	TPR-like_helical_dom	NPHP3 TMTC3 TTC21A TCF25 TTC34	4.67e-04	233	52	5	IPR011990
Domain	TPR_repeat	NPHP3 TMTC3 TTC21A TTC34	5.11e-04	133	52	4	IPR019734
Domain	TPR-contain_dom	NPHP3 TMTC3 TTC21A TTC34	8.02e-04	150	52	4	IPR013026
Domain	TPR_REGION	NPHP3 TMTC3 TTC21A TTC34	1.14e-03	165	52	4	PS50293
Domain	TPR	NPHP3 TMTC3 TTC21A TTC34	1.14e-03	165	52	4	PS50005
Domain	Apc4_WD40_dom	NWD1 EML5	1.40e-03	20	52	2	IPR024977
Domain	ANAPC4_WD40	NWD1 EML5	1.40e-03	20	52	2	PF12894
Domain	SPRY	TRIML2 HERC1 RYR3	1.83e-03	87	52	3	SM00449
Domain	TPR_1	NPHP3 TMTC3 TTC21A	2.02e-03	90	52	3	PF00515
Domain	TPR_1	NPHP3 TMTC3 TTC21A	2.02e-03	90	52	3	IPR001440
Domain	P-loop_NTPase	NWD1 NPHP3 RHOBTB2 SMC6 ABCF2 ARHGAP35 DICER1 MYO5C	2.23e-03	848	52	8	IPR027417
Domain	SPRY	TRIML2 HERC1 RYR3	2.28e-03	94	52	3	PF00622
Domain	SPRY_dom	TRIML2 HERC1 RYR3	2.28e-03	94	52	3	IPR003877
Domain	B30.2/SPRY	TRIML2 HERC1 RYR3	2.35e-03	95	52	3	IPR001870
Domain	B302_SPRY	TRIML2 HERC1 RYR3	2.35e-03	95	52	3	PS50188
Domain	RA	RIN1 GRB10	3.36e-03	31	52	2	SM00314
Domain	-	NWD1 NPHP3 RHOBTB2 SMC6 ABCF2 ARHGAP35 DICER1	4.41e-03	746	52	7	3.40.50.300
Domain	RA	RIN1 GRB10	4.51e-03	36	52	2	PF00788
Domain	RA	RIN1 GRB10	4.76e-03	37	52	2	PS50200
Domain	RA_dom	RIN1 GRB10	5.54e-03	40	52	2	IPR000159
Domain	EF-hand-dom_pair	RASGRP3 MACF1 CCAR2 RYR3	8.29e-03	287	52	4	IPR011992
Pubmed	DBC2, a candidate for a tumor suppressor gene involved in breast cancer.	RHOBTB2 CCAR2	2.46e-06	2	55	2	12370419
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	2.46e-06	2	55	2	11687802
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	2.46e-06	2	55	2	34910522
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RHOBTB2 TCF25 GRB10 MACF1 CCAR2 URB2 PCDH10	3.57e-06	407	55	7	12693553
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TBC1D32 RIN1 NPHP3 EML5 NUP107 AP2B1 RB1 TTC21A SMC6 CCAR2 DICER1	5.86e-06	1321	55	11	27173435
Pubmed	Interaction between AP-5 and the hereditary spastic paraplegia proteins SPG11 and SPG15.	AP5B1 ZFYVE26	7.36e-06	3	55	2	23825025
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	7.36e-06	3	55	2	30801007
Pubmed	C/EBPdelta expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation.	CEBPD RB1	7.36e-06	3	55	2	15674331
Pubmed	Monoallelic but not biallelic loss of Dicer1 promotes tumorigenesis in vivo.	RB1 DICER1	7.36e-06	3	55	2	20019750
Pubmed	CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells.	CEBPD RB1	7.36e-06	3	55	2	20971808
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	1.47e-05	4	55	2	18849963
Pubmed	Retinoblastoma protein positively regulates terminal adipocyte differentiation through direct interaction with C/EBPs.	CEBPD RB1	1.47e-05	4	55	2	8946919
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	DCPS NUP107 SMC6 URB2 PARP14 THOC2	1.62e-05	340	55	6	29478914
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	TMTC3 NUP107 PARP14 DICER1 MYO5C	1.73e-05	202	55	5	33005030
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	SMC6 TCF25 SNU13 MACF1 ABCF2 CCAR2 URB2 THOC2	2.44e-05	759	55	8	35915203
Pubmed	A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia.	AP5B1 ZFYVE26	2.45e-05	5	55	2	20613862
Pubmed	Maternally-inherited Grb10 reduces placental size and efficiency.	AFP GRB10	2.45e-05	5	55	2	19833122
Pubmed	Modeling germline mutations in pineoblastoma uncovers lysosome disruption-based therapy.	RB1 DICER1	2.45e-05	5	55	2	32286280
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	2.45e-05	5	55	2	24920589
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	NUP107 HAUS5 MACF1 ABCF2 CCAR2 URB2 THOC2 DICER1 MYO5C	3.02e-05	1024	55	9	24711643
Pubmed	Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.	RB1 DICER1	3.67e-05	6	55	2	22864477
Pubmed	Assessment and disease comparisons of hybrid developmental defects.	RB1 GRB10	5.13e-05	7	55	2	17339267
Pubmed	CCAAT/enhancer binding protein alpha knock-in mice exhibit early liver glycogen storage and reduced susceptibility to hepatocellular carcinoma.	CEBPD AFP	5.13e-05	7	55	2	16288022
Pubmed	Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane.	STRC STRCP1	6.83e-05	8	55	2	21165971
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NUP107 AP2B1 MACF1 CCAR2 URB2 THOC2 DICER1	7.40e-05	653	55	7	22586326
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	STRC STRCP1	1.34e-04	11	55	2	31448880
Pubmed	Otogelin, otogelin-like, and stereocilin form links connecting outer hair cell stereocilia to each other and the tectorial membrane.	STRC STRCP1	1.34e-04	11	55	2	31776257
Pubmed	Microsatellite scan identifies new candidate genes for susceptibility to alcoholic chronic pancreatitis in Japanese patients.	AVEN RYR3	1.34e-04	11	55	2	19096130
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	RIN1 TCF25 ABCF2	1.39e-04	63	55	3	34718347
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	NUP107 SMC6 TCF25 SNU13 PARP14	2.05e-04	341	55	5	32971831
Pubmed	Promoting axon regeneration in the adult CNS by modulation of the PTEN/mTOR pathway.	RB1 DICER1	2.21e-04	14	55	2	18988856
Pubmed	Deficiency of autotaxin/lysophospholipase D results in head cavity formation in mouse embryos through the LPA receptor-Rho-ROCK pathway.	AFP ENG	2.54e-04	15	55	2	20692235
Pubmed	Mammalian Otolin: a multimeric glycoprotein specific to the inner ear that interacts with otoconial matrix protein Otoconin-90 and Cerebellin-1.	STRC STRCP1	3.29e-04	17	55	2	20856818
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	EML5 NUP107 RB1 HAUS5 TCF25 MACF1 DICER1 BAHCC1	3.50e-04	1116	55	8	31753913
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	AP2B1 HAUS5 SNU13 MACF1 ABCF2 CCAR2 THOC2	3.64e-04	847	55	7	35235311
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	RHOBTB2 MACF1 ARHGAP35 DICER1	4.49e-04	225	55	4	12168954
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	ABCF2 CCAR2 HERC1 RYR3	4.96e-04	231	55	4	36597993
Pubmed	The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA.	ZBTB25 SMC6 PARP14 THOC2	7.94e-04	262	55	4	36880596
Pubmed	Embryonic Steroids Control Developmental Programming of Energy Balance.	AFP PKLR	8.40e-04	27	55	2	34599818
Pubmed	Genetic link between renal birth defects and congenital heart disease.	TBC1D32 AP2B1	9.04e-04	28	55	2	27002738
Pubmed	Molecular signatures and cellular diversity during mouse habenula development.	KCNG4 PCDH10	9.04e-04	28	55	2	35793630
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	RIN1 TMTC3 SNU13 MACF1 URB2 HERC1	9.37e-04	719	55	6	35337019
Pubmed	Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.	RB1 MACF1	9.70e-04	29	55	2	18239623
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	AVEN SMC6 MACF1 ABCF2 ARHGAP35 DICER1	9.71e-04	724	55	6	36232890
Pubmed	Dissection of behavior and psychiatric disorders using the mouse as a model.	CEBPD RYR3	1.11e-03	31	55	2	10767319
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	SNU13 CCAR2 HERC1	1.11e-03	128	55	3	28027390
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	AP2B1 RB1 ZBTB25 ARHGAP35 ENG	1.15e-03	499	55	5	22810586
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	GRB10 MACF1 BAHCC1	1.16e-03	130	55	3	12421765
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	RIN1 NUP107 AP2B1 RB1 MACF1 ABCF2 CCAR2 URB2	1.23e-03	1353	55	8	29467282
Pubmed	The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.	AP2B1 TCF25 GRB10 ABCF2	1.28e-03	298	55	4	30737378
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MACF1 DICER1	1.33e-03	34	55	2	25925205
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	AVEN NUP107 SMC6 PKLR CCAR2 PCDH10	1.39e-03	777	55	6	35844135
Interaction	C2CD4B interactions	RB1 TCF25 MACF1 HERC1 DICER1	1.04e-07	44	53	5	int:C2CD4B
Interaction	ADAMTS13 interactions	TCF25 MACF1 HERC1 DICER1	6.10e-07	26	53	4	int:ADAMTS13
Cytoband	15q15.3	STRC STRCP1	4.31e-04	25	56	2	15q15.3
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	NPHP3 TMTC3 TTC21A TTC34	7.82e-05	115	36	4	769
GeneFamily	EF-hand domain containing	RASGRP3 MACF1 RYR3	9.33e-03	219	36	3	863
GeneFamily	WD repeat domain containing	NWD1 EML5 HERC1	1.51e-02	262	36	3	362
Coexpression	GSE5589_LPS_VS_LPS_AND_IL6_STIM_IL10_KO_MACROPHAGE_45MIN_DN	DPH2 ZBTB25 ABCF2 URB2 ARHGAP35	6.13e-05	199	55	5	M6632
Coexpression	GSE29164_DAY3_VS_DAY7_UNTREATED_MELANOMA_DN	TMTC3 RASGRP3 ZFYVE26 UAP1L1 DICER1	6.13e-05	199	55	5	M8487
Coexpression	GSE3982_MAST_CELL_VS_NEUTROPHIL_UP	AVEN AP2B1 AFP GRB10 HERC1	6.13e-05	199	55	5	M5432
Coexpression	GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP	RB1 TTC21A SMC6 MACF1 PARP14	6.13e-05	199	55	5	M9238
Coexpression	GSE24026_PD1_LIGATION_VS_CTRL_IN_ACT_TCELL_LINE_DN	NUP107 SMC6 TATDN2 ZFYVE26 HERC1	6.28e-05	200	55	5	M4538
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	3.41e-06	2	55	2	DOID:0110471 (implicated_via_orthology)
Disease	Lissencephaly	TMTC3 MACF1	5.09e-05	6	55	2	C0266463
Disease	glucagon measurement, glucose tolerance test	MACF1 HERC1	5.09e-05	6	55	2	EFO_0004307, EFO_0008463
Disease	embryonal carcinoma (is_marker_for)	RB1 AFP	7.12e-05	7	55	2	DOID:3308 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, response to escitalopram, response to citalopram	TRIML2 TTC34	9.17e-04	24	55	2	EFO_0004611, EFO_0006329, EFO_0007871
Disease	hepatocellular carcinoma (biomarker_via_orthology)	RB1 AFP ENG	1.09e-03	108	55	3	DOID:684 (biomarker_via_orthology)
Disease	3-methoxytyrosine measurement	RB1 GRB10	1.16e-03	27	55	2	EFO_0021009

Protein segments in the cluster

Peptide	Gene	Start	Entry
ISLNHLILEPDLDDL	URB2	416	Q14146
EDLCEMALDPELLLL	CCAR2	641	Q8N163
DHDLDLCVPIFTLLQ	BEST2	266	Q8NFU1
LLDEPTNHLDLDACV	ABCF2	251	Q9UG63
DDEDPALLLQTCLTH	BAHCC1	2381	Q9P281
EPTLLDELICHIGSL	AP2B1	556	P63010
PSLECAEEILLHLEE	TBC1D32	31	Q96NH3
LLSEPACAHALEALA	DPH2	151	Q9BQC3
VLLLCDHEAFLDVLD	ANKRD35	136	Q8N283
LLVFDECHLAILDHP	DICER1	171	Q9UPY3
HLLAEVIENLECDPR	DCPS	296	Q96C86
FLLQLDSCHLDLGPE	ENG	486	P17813
EDLLDDFDLCAPHLD	NWD1	766	Q149M9
CERLLSEHPELEHII	RB1	666	P06400
GTHLLVPCLEEEELA	ANKRD33	56	Q7Z3H0
LPAEDDNAIREHLCI	NUP107	736	P57740
LALHVLEAVLPACES	HERC1	1956	Q15751
ECELLDPHVASEHEL	KCNG4	486	Q8TDN1
SLLILDIPDDCEEHE	PNMA6F	16	A0A0J9YX94
EPLEIILHLPLLCED	SNU13	61	P55769
EHLCLLDIDSEPVAA	PKLR	71	P30613
LHLLCLLCAEEEEEE	AP5B1	416	Q2VPB7
CLEEEVRHLPHILLG	HAUS5	446	O94927
CVLHLEVFLENPLEL	PCDH10	91	Q9P2E7
CELPLDDQVALLRAH	HNF4G	161	Q14541
LSCSHPLELLEEATL	MACF1	2276	Q9UPN3
LLDHLLTECPEIEIC	PARP14	486	Q460N5
VPTLELCHDELFADL	CEBPD	71	P49716
HLEEELDLLLNLDAP	AVEN	281	Q9NQS1
EDEELEHLRLLEPHC	C7	546	P10643
CHLIRPLDTVLDDSI	ASNSD1	446	Q9NWL6
PHLGLERCLEDHELV	GRB10	216	Q13322
HDDDILCLTIHPLKD	EML5	726	Q05BV3
LPAFLEELCHEKEIL	AFP	91	P02771
ADEFLPLLSLVLAHC	RIN1	536	Q13671
VLAHCDLPELLLEAE	RIN1	546	Q13671
PLVIHCREADEDLLE	TATDN2	626	Q93075
FIHLTLPSLLLEDCE	NPHP3	366	Q7Z494
LLFDHLEPIELAEHL	RASGRP3	146	Q8IV61
PAHLLEDPLCADVIL	RHOBTB2	256	Q9BYZ6
LIPNLDEIDHLSCIK	ARHGAP35	351	Q9NRY4
LLPRHDLSLEELCSL	STRC	1041	Q7RTU9
DLSLEELCSLHLLLP	STRC	1046	Q7RTU9
QEHLDLPCALESELT	ZBTB25	411	P24278
LEHLEPAHITDLSLC	TRIML2	221	Q8N7C3
DALLDHDLALPLCLL	THOC2	731	Q8NI27
EDLLLHCGVPLEEEE	RYR3	1901	Q15413
AELALLEPEALREHC	UAP1L1	36	Q3KQV9
CIHLRDPELALAIES	SMC6	511	Q96SB8
HAAVRLAELLTPEEC	TMDD1	31	P0DPE3
RCLELDPASVDAHLL	TTC21A	526	Q8NDW8
LLPRHDLSLEELCSL	STRCP1	1041	A6NGW2
DLSLEELCSLHLLLP	STRCP1	1046	A6NGW2
AERCLLETLALAPHE	TMTC3	791	Q6ZXV5
IDCEPLLLNVLHLDT	USP40	636	Q9NVE5
LAEVDAPDLSCLLHL	TTC34	366	A8MYJ7
APDLSCLLHLLEASE	TTC34	371	A8MYJ7
PLGVELHLLCEELLE	ZFYVE26	231	Q68DK2
DEDPLCMLLLIDHLA	TCF25	376	Q9BQ70
MGILELLDEECLLPH	MYO5C	501	Q9NQX4