Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionDNA damage sensor activity

MLH1 SIRT6

1.64e-0424162GO:0140612
GeneOntologyMolecularFunctionhistone H3 demethylase activity

KDM5A KDM3A

2.25e-0428162GO:0141052
GeneOntologyMolecularFunctionhistone demethylase activity

KDM5A KDM3A

2.76e-0431162GO:0032452
GeneOntologyMolecularFunctionprotein demethylase activity

KDM5A KDM3A

2.94e-0432162GO:0140457
GeneOntologyMolecularFunctionchromatin DNA binding

KDM5A KDM3A SIRT6

2.97e-04167163GO:0031490
GeneOntologyMolecularFunctiondemethylase activity

KDM5A KDM3A

5.58e-0444162GO:0032451
GeneOntologyMolecularFunctionmolecular sensor activity

MLH1 SIRT6

7.21e-0450162GO:0140299
GeneOntologyMolecularFunctionhistone modifying activity

KDM5A KDM3A SIRT6

7.47e-04229163GO:0140993
GeneOntologyMolecularFunction2-oxoglutarate-dependent dioxygenase activity

KDM5A KDM3A

1.22e-0365162GO:0016706
GeneOntologyMolecularFunctionchromatin binding

MLH1 KDM5A KDM3A SIRT6

2.37e-03739164GO:0003682
GeneOntologyMolecularFunctiondioxygenase activity

KDM5A KDM3A

2.74e-0398162GO:0051213
GeneOntologyMolecularFunctionSH3 domain binding

CD2AP SIRPA

5.72e-03143162GO:0017124
GeneOntologyMolecularFunctionnucleotidyltransferase activity

POLD3 SIRT6

6.44e-03152162GO:0016779
GeneOntologyMolecularFunctiontranscription coregulator activity

KDM5A KDM3A SIRT6

9.45e-03562163GO:0003712
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

KDM5A KDM3A

1.03e-02194162GO:0016705
GeneOntologyCellularComponentmale germ cell nucleus

MLH1 KDM3A

2.19e-0386172GO:0001673
GeneOntologyCellularComponentgerm cell nucleus

MLH1 KDM3A

3.74e-03113172GO:0043073
DomainJmjC

KDM5A KDM3A

1.64e-0424152PF02373
DomainJMJC

KDM5A KDM3A

2.94e-0432152PS51184
DomainJmjC_dom

KDM5A KDM3A

2.94e-0432152IPR003347
DomainJmjC

KDM5A KDM3A

3.13e-0433152SM00558
DomainZinc_finger_PHD-type_CS

KDM5A NFX1

1.22e-0365152IPR019786
DomainZnf_PHD-finger

KDM5A NFX1

1.79e-0379152IPR019787
DomainZnf_FYVE_PHD

KDM5A KDM3A

6.04e-03147152IPR011011
PathwayREACTOME_MISMATCH_REPAIR

MLH1 POLD3

8.19e-0515132M27442
PathwayREACTOME_MISMATCH_REPAIR

MLH1 POLD3

8.19e-0515132MM15184
PathwayWP_DNA_MISMATCH_REPAIR

MLH1 POLD3

1.96e-0423132M39668
PathwayKEGG_MISMATCH_REPAIR

MLH1 POLD3

1.96e-0423132M13515
PathwayKEGG_MEDICUS_REFERENCE_MISMATCH_REPAIR

MLH1 POLD3

2.52e-0426132M47827
PathwayWP_MALE_INFERTILITY

MLH1 KDM3A SIRPA

2.83e-04145133M39856
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5A KDM3A

3.14e-0429132MM14934
PathwayREACTOME_HDMS_DEMETHYLATE_HISTONES

KDM5A KDM3A

9.38e-0450132M27232
Pubmed

Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis.

MLH1 POLD3

3.37e-06617229447390
Pubmed

Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor.

CD2AP SIRPA PEAK1

1.66e-0510317321706016
Pubmed

Foxl2 is required for commitment to ovary differentiation.

MLH1 LAMA1

3.42e-051817215944199
Pubmed

Multiplexed barcoded CRISPR-Cas9 screening enabled by CombiGEM.

KDM5A KDM3A

1.18e-043317226864203
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

GTF3C2 KDM3A CD2AP PEAK1

1.24e-0454917438280479
Pubmed

Large-scale identification of genes implicated in kidney glomerulus development and function.

CD2AP LAMA1

1.25e-043417216498405
Pubmed

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement).

GTF3C2 POLD3

1.48e-04371727584028
Pubmed

A conserved acetylation switch enables pharmacological control of tubby-like protein stability.

GTF3C2 GPC6 POLD3

1.65e-0422317333187986
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

GTF3C2 MLH1 KDM5A KDM3A

1.84e-0460817436089195
Pubmed

Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

GTF3C2 POLD3

2.01e-04431727584026
Pubmed

Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.

KDM5A KDM3A

2.10e-044417224183668
Pubmed

Identification of Jmjd3 as an Essential Epigenetic Regulator of Hox Gene Temporal Collinear Activation for Body Axial Patterning in Mice.

KDM5A KDM3A

2.61e-044917234368113
Pubmed

New nomenclature for chromatin-modifying enzymes.

KDM5A KDM3A

3.53e-045717218022353
Pubmed

EB1-binding-myomegalin protein complex promotes centrosomal microtubules functions.

GPC6 CD2AP

4.32e-046317229162697
CytobandEnsembl 112 genes in cytogenetic band chr12p13

KDM5A ANO2

7.43e-03353172chr12p13
GeneFamilyPHD finger proteins|Lysine demethylases

KDM5A KDM3A

1.11e-0424122485
GeneFamilyPHD finger proteins

KDM5A NFX1

1.57e-039012288
CoexpressionAtlasDevelopingKidney_e15.5_Medullary collecting duct_emap-28063_k-means-cluster#4_top-relative-expression-ranked_1000

GTF3C2 GPC6 KDM5A CD2AP

2.74e-05261154gudmap_developingKidney_e15.5_Medullary collecting duct_1000_k4
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_k-means-cluster#5_top-relative-expression-ranked_1000

GPC6 KDM5A CD2AP POLD3

7.58e-05339154gudmap_developingKidney_e15.5_ureter tip_flank cortic collct_1000_k5
CoexpressionAtlasDevelopingKidney_e15.5_ureter tip_flank cortic collct_emap-27752_top-relative-expression-ranked_1000

GPC6 KDM5A CD2AP POLD3 LAMA1

1.65e-04801155gudmap_developingKidney_e15.5_ureter tip_1000_flank cortic collct
DiseaseColorectal Neoplasms

MLH1 POLD3 LAMA1

4.19e-04277163C0009404
Diseaseplatelet component distribution width

MLH1 NUP210L CD2AP SIRPA

6.05e-04755164EFO_0007984
Diseaseimmature platelet count

CD2AP SIRPA

1.48e-03106162EFO_0803544
Diseasecarotid artery intima media thickness

GPC6 CD2AP SIRPA

1.70e-03450163EFO_0007117
Diseaseimmature platelet fraction

CD2AP SIRPA

1.71e-03114162EFO_0009187
Diseaseimmature platelet measurement

CD2AP SIRPA

1.87e-03119162EFO_0803541
Diseasepelvic organ prolapse

GPC6 POLD3

2.43e-03136162EFO_0004710
DiseaseProfound Mental Retardation

KDM5A LAMA1

2.53e-03139162C0020796
DiseaseMental deficiency

KDM5A LAMA1

2.53e-03139162C0917816
DiseaseMental Retardation, Psychosocial

KDM5A LAMA1

2.53e-03139162C0025363
Diseasefacial height measurement

GPC6 ANO2

2.64e-03142162EFO_0007856
Diseaseprostate cancer (is_marker_for)

KDM5A KDM3A

3.17e-03156162DOID:10283 (is_marker_for)
Diseaselung non-small cell carcinoma (is_marker_for)

MLH1 KDM5A

3.71e-03169162DOID:3908 (is_marker_for)
Diseasebody composition measurement

GPC6 POLD3

4.81e-03193162EFO_0005106
Diseasealcohol use disorder (implicated_via_orthology)

KDM5A KDM3A

4.91e-03195162DOID:1574 (implicated_via_orthology)
DiseaseAbnormality of refraction

GPC6 KDM5A PEAK1

5.30e-03673163HP_0000539
DiseaseColorectal Carcinoma

MLH1 POLD3 LAMA1

5.96e-03702163C0009402
Diseasebiological sex

GPC6 PEAK1

6.76e-03230162PATO_0000047

Protein segments in the cluster

PeptideGeneStartEntry
PAGGIQPHPQTKNIK

CD2AP

91

Q9Y5K6
PKHGQQCLKMPGPRA

ANO2

31

Q9NQ90
GPNVPPRKNCHKSAP

PEAK1

556

Q9H792
PCNKSPKSHGLQNQP

NFX1

91

Q12986
INCAKKQGPVSPGPA

KDM5A

1656

P29375
KVFQGCGQPKPAPAL

GPC6

336

Q9Y625
PPNLGAKIPQGCHKQ

KDM3A

326

Q9Y4C1
NGKPLCSQLQHVPPQ

CPHXL2

336

A0A1W2PPK0
KLHPDKNPNNPNAHG

DNAJC10

61

Q8IXB1
VPAGAQPCPLPQHNK

NUP210L

771

Q5VU65
SDLHNGKQPGQCPCK

LAMA1

416

P25391
KGKKPAPQAAEPNNH

SIRPA

436

P78324
GHGPPASKQVSQQPK

POLD3

176

Q15054
KAPPKPCAGNQGTQI

MLH1

136

P40692
IPAGPKQEPCAQHNG

SIRT6

311

Q8N6T7
LHKCPGINQDPGPHK

SPEM3

971

A0A1B0GUW6
KQKPHCRGMAPNGLP

GTF3C2

286

Q8WUA4
KNPKSLAGCLLPNPH

nan

11

Q6ZTC4