Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN4 HCN1	7.87e-05	10	27	2	GO:0005222
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN4 HCN1	1.36e-04	13	27	2	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN4 HCN1	1.36e-04	13	27	2	GO:0043855
GeneOntologyMolecularFunction	cAMP binding	HCN4 HCN1	5.18e-04	25	27	2	GO:0030552
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	HCN4 HCN1	5.61e-04	26	27	2	GO:0005248
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 HCN1	9.06e-04	33	27	2	GO:0005217
GeneOntologyMolecularFunction	cyclic nucleotide binding	HCN4 HCN1	1.27e-03	39	27	2	GO:0030551
GeneOntologyMolecularFunction	sodium channel activity	HCN4 HCN1	2.24e-03	52	27	2	GO:0005272
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN1	1.11e-05	4	29	2	GO:0098855
Domain	TMEM191C	TMEM191B TMEM191C	2.33e-06	2	29	2	PF15194
Domain	TMEM191B/C	TMEM191B TMEM191C	2.33e-06	2	29	2	IPR028186
Domain	Ion_trans_N	HCN4 HCN1	1.39e-05	4	29	2	PF08412
Domain	Ion_trans_N	HCN4 HCN1	1.39e-05	4	29	2	IPR013621
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN1	2.09e-04	14	29	2	IPR003938
Domain	cNMP-bd_CS	HCN4 HCN1	2.76e-04	16	29	2	IPR018488
Domain	CNMP_BINDING_1	HCN4 HCN1	1.12e-03	32	29	2	PS00888
Domain	CNMP_BINDING_2	HCN4 HCN1	1.12e-03	32	29	2	PS00889
Domain	cNMP	HCN4 HCN1	1.27e-03	34	29	2	SM00100
Domain	cNMP_binding	HCN4 HCN1	1.27e-03	34	29	2	PF00027
Domain	cNMP-bd_dom	HCN4 HCN1	1.34e-03	35	29	2	IPR000595
Domain	CNMP_BINDING_3	HCN4 HCN1	1.34e-03	35	29	2	PS50042
Domain	cNMP-bd-like	HCN4 HCN1	1.58e-03	38	29	2	IPR018490
Domain	-	HCN4 HCN1	2.51e-03	48	29	2	2.60.120.10
Domain	RmlC-like_jellyroll	HCN4 HCN1	2.83e-03	51	29	2	IPR014710
Domain	HEAT	TOGARAM1 ATR	3.65e-03	58	29	2	IPR000357
Domain	HEAT_REPEAT	TOGARAM1 ATR	5.27e-03	70	29	2	PS50077
Domain	Ion_trans_dom	HCN4 HCN1	1.35e-02	114	29	2	IPR005821
Domain	Ion_trans	HCN4 HCN1	1.35e-02	114	29	2	PF00520
Pubmed	Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in Melanocytes.	ATR MC1R	6.71e-07	2	29	2	26168232
Pubmed	Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells.	HCN4 HCN1	6.71e-07	2	29	2	19135060
Pubmed	Peripheral N- and C-terminal domains determine deactivation kinetics of HCN channels.	HCN4 HCN1	6.71e-07	2	29	2	17548059
Pubmed	Colocalization of hyperpolarization-activated, cyclic nucleotide-gated channel subunits in rat retinal ganglion cells.	HCN4 HCN1	6.71e-07	2	29	2	21456027
Pubmed	Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli.	HCN4 HCN1	6.71e-07	2	29	2	11675786
Pubmed	TERT promoter mutations associate with MC1R variants in melanoma patients.	TERT MC1R	6.71e-07	2	29	2	27930874
Pubmed	EP3 activation facilitates bladder excitability via HCN channels on ICCs.	HCN4 HCN1	2.01e-06	3	29	2	28131828
Pubmed	HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes.	HCN4 HCN1	2.01e-06	3	29	2	33181864
Pubmed	Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart.	HCN4 HCN1	2.01e-06	3	29	2	22652004
Pubmed	Cytoplasmic cAMP-sensing domain of hyperpolarization-activated cation (HCN) channels uses two structurally distinct mechanisms to regulate voltage gating.	HCN4 HCN1	2.01e-06	3	29	2	21187420
Pubmed	Novel insights into the distribution of cardiac HCN channels: an expression study in the mouse heart.	HCN4 HCN1	2.01e-06	3	29	2	21945247
Pubmed	Pot1b deletion and telomerase haploinsufficiency in mice initiate an ATR-dependent DNA damage response and elicit phenotypes resembling dyskeratosis congenita.	ATR TERT	2.01e-06	3	29	2	18936156
Pubmed	Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	2.01e-06	3	29	2	22006928
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN1	4.02e-06	4	29	2	16043489
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN1	4.02e-06	4	29	2	22748890
Pubmed	Germline MC1R variants and frequency of somatic BRAF, NRAS, and TERT mutations in melanoma: Literature review and meta-analysis.	TERT MC1R	4.02e-06	4	29	2	33444485
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN1	4.02e-06	4	29	2	9630217
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN1	4.02e-06	4	29	2	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN1	4.02e-06	4	29	2	12928435
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN4 HCN1	4.02e-06	4	29	2	21615589
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN1	4.02e-06	4	29	2	20140458
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN4 HCN1	6.70e-06	5	29	2	34429357
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN4 HCN1	6.70e-06	5	29	2	15564593
Pubmed	Galanin receptor 3 - A new pharmacological target in retina degeneration.	RDH8 GALR3	6.70e-06	5	29	2	36693600
Pubmed	Differential expression of hyperpolarization-activated cyclic nucleotide-gated channel subunits during hippocampal development in the mouse.	HCN4 HCN1	1.00e-05	6	29	2	25761792
Pubmed	Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.	HCN4 HCN1	1.41e-05	7	29	2	19421833
Pubmed	Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replication.	ATR TERT	1.41e-05	7	29	2	21829167
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	HCN4 HCN1	3.01e-05	10	29	2	16382102
Pubmed	Arrhythmia induced by spatiotemporal overexpression of calreticulin in the heart.	HCN4 HCN1	4.41e-05	12	29	2	17482496
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN4 HCN1	6.07e-05	14	29	2	29107716
Pubmed	Genome-wide association study identifies three new melanoma susceptibility loci.	TERT MC1R	6.07e-05	14	29	2	21983787
Pubmed	HORMAD1-dependent checkpoint/surveillance mechanism eliminates asynaptic oocytes.	USP26 ATR	7.00e-05	15	29	2	22530760
Pubmed	Hyperpolarization-activated cyclic nucleotide-gated channels in olfactory sensory neurons regulate axon extension and glomerular formation.	HCN4 HCN1	7.00e-05	15	29	2	21147989
Pubmed	Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature.	HCN4 HCN1	1.02e-04	18	29	2	27180262
Pubmed	Cyclic-Nucleotide- and HCN-Channel-Mediated Phototransduction in Intrinsically Photosensitive Retinal Ganglion Cells.	HCN4 HCN1	1.40e-04	21	29	2	30270038
Pubmed	Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria.	HCN4 HCN1	3.08e-04	31	29	2	17473172
Pubmed	Proteomic analysis of p16ink4a-binding proteins.	USP26 UBE4B	3.49e-04	33	29	2	17955473
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TCAF1 BRINP1 ATR MOV10	5.61e-04	462	29	4	31138677
Pubmed	Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia.	HCN4 HCN1	6.79e-04	46	29	2	37207277
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TOGARAM1 TCAF1 MOV10 FARP2	7.15e-04	493	29	4	15368895
Interaction	PTPA interactions	BRINP1 UBE4B TERT MOV10	1.37e-05	115	26	4	int:PTPA
Interaction	HCN4 interactions	HCN4 HCN1	5.73e-05	9	26	2	int:HCN4
Interaction	CDKN2A interactions	USP26 ATR UBE4B TERT MOV10	6.08e-05	335	26	5	int:CDKN2A
Interaction	HCN3 interactions	HCN4 HCN1	8.74e-05	11	26	2	int:HCN3
Cytoband	Xq26.2	USP26 HS6ST2	1.44e-04	28	29	2	Xq26.2
Cytoband	22q11.21	TMEM191B TMEM191C	2.25e-03	111	29	2	22q11.21
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN1	2.88e-05	10	15	2	250
Coexpression	FONTAINE_FOLLICULAR_THYROID_ADENOMA_DN	TENM1 IGSF10 ATR	6.34e-05	70	29	3	M5370
Coexpression	GSE29618_PRE_VS_DAY7_FLU_VACCINE_MDC_UP	TENM1 TOGARAM1 ENTPD4 MC1R	6.34e-05	197	29	4	M4980
Coexpression	GSE29618_PRE_VS_DAY7_POST_LAIV_FLU_VACCINE_MDC_UP	TENM1 TOGARAM1 MC1R FARP2	6.47e-05	198	29	4	M5007
Drug	zatebradine	HCN4 HCN1 FARP2	1.12e-06	17	28	3	CID000065637
Disease	sick sinus syndrome (implicated_via_orthology)	HCN4 HCN1	2.42e-06	3	27	2	DOID:13884 (implicated_via_orthology)
Disease	Ovarian cyst	TERT IFNL4	8.05e-06	5	27	2	HP_0000138
Disease	Familial melanoma	TERT MC1R	2.25e-05	8	27	2	cv:C1512419
Disease	Malignant melanoma of skin	TERT MC1R	2.25e-05	8	27	2	cv:C0151779
Disease	Melanoma	TERT MC1R	2.25e-05	8	27	2	cv:C0025202
Disease	familial melanoma (is_implicated_in)	TERT MC1R	2.89e-05	9	27	2	DOID:6846 (is_implicated_in)
Disease	Familial Atypical Mole Melanoma Syndrome	TERT MC1R	4.41e-05	11	27	2	C2314896
Disease	melanoma	TERT MC1R FARP2	2.06e-04	126	27	3	EFO_0000756
Disease	Pigmented Basal Cell Carcinoma	TERT MC1R	3.00e-04	28	27	2	C1368275
Disease	Carcinoma, Basal Cell	TERT MC1R	3.22e-04	29	27	2	C4721806
Disease	melanoma (is_implicated_in)	TERT MC1R	4.44e-04	34	27	2	DOID:1909 (is_implicated_in)
Disease	hepatocellular carcinoma	TERT IFNL4	6.47e-04	41	27	2	EFO_0000182
Disease	liver cirrhosis (is_implicated_in)	PHKG2 IFNL4	7.11e-04	43	27	2	DOID:5082 (is_implicated_in)
Disease	nasopharynx carcinoma (is_marker_for)	ATR TERT	7.11e-04	43	27	2	DOID:9261 (is_marker_for)
Disease	fibrinogen measurement, tissue plasminogen activator measurement	PKD1L3 FARP2	7.79e-04	45	27	2	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	PKD1L3 FARP2	7.79e-04	45	27	2	EFO_0004623, EFO_0004792
Disease	factor XI measurement, fibrinogen measurement, tissue plasminogen activator measurement, factor VII measurement	PKD1L3 FARP2	1.20e-03	56	27	2	EFO_0004619, EFO_0004623, EFO_0004694, EFO_0004791
Disease	serum albumin measurement	PHKG2 PKD1L3 TERT FARP2	1.95e-03	592	27	4	EFO_0004535
Disease	skin neoplasm	TERT MC1R	2.09e-03	74	27	2	EFO_0004198

Protein segments in the cluster

Peptide	Gene	Start	Entry
SRLPRILIVHLKRYS	USP26	511	Q9BXU7
RHLETLIRSYPDIRR	EXOC3L4	646	Q17RC7
LRYRHCLTTLTVPRR	EPC2	431	Q52LR7
HIYLRSRTRLPTLLR	BRINP1	616	O60477
RYHSIVTLPRARRAV	MC1R	151	Q01726
RYSSRRATPRHIIVR	L1RE1	206	Q9UN81
LLRDPYALRSVRHLI	PHKG2	336	P15735
LRLLRLSRLIRYIHQ	HCN4	386	Q9Y3Q4
LYVRTTHRLLFRCPR	RDH8	276	Q9NYR8
YLAVRHPLRSRALRT	GALR3	121	O60755
RRRELHIRTYAVIPL	ATR	2356	Q13535
LRLLRLSRLIRYIHQ	HCN1	266	O60741
RIISPYRTPVLRRHR	IGSF10	1021	Q6WRI0
SLSLPSRHRLFLTYR	B3GNT4	86	Q9C0J1
LSIHRLTLERPALRY	C9orf43	261	Q8TAL5
RCLLSHYRSLEPRTL	IFNL4	26	K9M1U5
RLRPSRNFHYITILR	HS6ST2	311	Q96MM7
PIQRLLHYRLLLRRL	FARP2	681	O94887
LHIVTRIKSTRRRPY	MRPL30	66	Q8TCC3
RRLRYTLSPLLELRA	TMEM191B	326	P0C7N4
LRRLRYTLSPLLELR	TMEM191C	326	A6NGB0
VHRLLRKLLSRYRLP	TCAF1	461	Q9Y4C2
RLRVHLPSSIYRLLA	MOV10	566	Q9HCE1
YLLRLRRIHRRTPRS	ENTPD4	581	Q9Y227
LRHSPRLRVISRTLS	PKD1L3	1571	Q7Z443
VRTAYPSLRLLHAVR	ST8SIA2	266	Q92186
LTPLRYDLRDRITRL	TENM1	2191	Q9UKZ4
HLSILPSCRRYIRRL	UBE4B	766	O95155
ISRLPSALRRHYNRR	TOGARAM1	296	Q9Y4F4
RSLLRSHYREVLPLA	TERT	11	O14746