Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TLC	CERS5 CERS6 TLCD3A	3.49e-05	16	76	3	PS50922
Domain	TLC	CERS5 CERS6 TLCD3A	3.49e-05	16	76	3	SM00724
Domain	TRAM_LAG1_CLN8	CERS5 CERS6 TLCD3A	3.49e-05	16	76	3	PF03798
Domain	TLC-dom	CERS5 CERS6 TLCD3A	3.49e-05	16	76	3	IPR006634
Domain	REJ	PKD1L1 PKDREJ	9.75e-05	4	76	2	PS51111
Domain	REJ_dom	PKD1L1 PKDREJ	9.75e-05	4	76	2	IPR014010
Domain	PKD/REJ-like	PKD1L1 PKDREJ	2.43e-04	6	76	2	IPR002859
Domain	REJ	PKD1L1 PKDREJ	2.43e-04	6	76	2	PF02010
Domain	Lag1/Lac1	CERS5 CERS6	2.43e-04	6	76	2	IPR016439
Domain	PKD_channel	PKD1L1 PKDREJ	8.78e-04	11	76	2	PF08016
Domain	PKD1_2_channel	PKD1L1 PKDREJ	8.78e-04	11	76	2	IPR013122
Domain	LH2	PKD1L1 PKDREJ	2.40e-03	18	76	2	SM00308
Domain	PLAT	PKD1L1 PKDREJ	3.26e-03	21	76	2	PS50095
Domain	-	PKD1L1 PKDREJ	3.26e-03	21	76	2	2.60.60.20
Domain	PLAT	PKD1L1 PKDREJ	3.26e-03	21	76	2	PF01477
Domain	PLAT/LH2_dom	PKD1L1 PKDREJ	3.26e-03	21	76	2	IPR001024
Domain	Quino_amine_DH_bsu	FSTL5 TENM2	3.58e-03	22	76	2	IPR011044
Pubmed	Defining the membrane proteome of NK cells.	DOCK2 CSGALNACT2 MYO5A MED16 EI24 CD48 CLN6 CHID1 CERS6 ZDHHC3 CIT CNOT1 MTCH2 ITPRIPL1 STT3A ITPR1	8.46e-09	1168	80	16	19946888
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	CERS5 CLSTN3 CSGALNACT2 JAGN1 PTGES EI24 OSBPL9 CLN6 CHID1 CERS6 MTCH2 CHRNA5 STT3A ATP6V0A2 ITPR1	8.79e-08	1201	80	15	35696571
Pubmed	A new functional motif in Hox domain-containing ceramide synthases: identification of a novel region flanking the Hox and TLC domains essential for activity.	CERS5 CERS6	5.23e-06	2	80	2	17609214
Pubmed	Generation of a ceramide synthase 6 mouse lacking the DDRSDIE C-terminal motif.	CERS5 CERS6	5.23e-06	2	80	2	35849604
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	EI24 CHID1 CERS6 SLC25A16 TLCD3A CHRNA5 STT3A	5.63e-06	296	80	7	34186245
Pubmed	CerS6-Derived Sphingolipids Interact with Mff and Promote Mitochondrial Fragmentation in Obesity.	CERS5 CERS6	1.57e-05	3	80	2	31150623
Pubmed	Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.	CERS5 CERS6	1.57e-05	3	80	2	20406683
Pubmed	The bcl-2 family member, Bcl2a1, maps to mouse chromosome 9 and human chromosome 15.	MYO5A CHRNA5	3.13e-05	4	80	2	9096119
Pubmed	Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.	CERS5 CERS6	3.13e-05	4	80	2	12912983
Pubmed	Do longevity assurance genes containing Hox domains regulate cell development via ceramide synthesis?	CERS5 CERS6	3.13e-05	4	80	2	12297269
Pubmed	Mammalian Lass6 and its related family members regulate synthesis of specific ceramides.	CERS5 CERS6	5.20e-05	5	80	2	15823095
Pubmed	Enzyme Activities of the Ceramide Synthases CERS2-6 Are Regulated by Phosphorylation in the C-terminal Region.	CERS5 CERS6	5.20e-05	5	80	2	26887952
Pubmed	Kinetic characterization of mammalian ceramide synthases: determination of K(m) values towards sphinganine.	CERS5 CERS6	7.79e-05	6	80	2	17977534
Pubmed	Oxidized phospholipids induce ceramide accumulation in RAW 264.7 macrophages: role of ceramide synthases.	CERS5 CERS6	7.79e-05	6	80	2	23936132
Pubmed	Dissecting the role of Rho-mediated signaling in contractile ring formation.	ECT2 CIT	7.79e-05	6	80	2	16236794
Pubmed	Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies.	OSBPL9 CNOT1	1.09e-04	7	80	2	29547901
Pubmed	Detection and mapping of quantitative trait loci for haloperidol-induced catalepsy in a C57BL/6J x DBA/2J F2 intercross.	MYO5A CHRNA5	1.09e-04	7	80	2	10765558
Pubmed	Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis.	CERS5 CERS6	1.45e-04	8	80	2	36543979
Pubmed	A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse.	MYO5A CHRNA5	1.45e-04	8	80	2	10805811
Pubmed	Genomic response to Wnt signalling is highly context-dependent--evidence from DNA microarray and chromatin immunoprecipitation screens of Wnt/TCF targets.	CLSTN3 TENM2	1.45e-04	8	80	2	19563800
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ACACA MYO5A GPR137C NETO1 AIG1 OSBPL9 ATP9B PARVB CERS6 SLC10A7 CNOT1 STT3A	1.48e-04	1489	80	12	28611215
Pubmed	Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells.	PKD1L1 PKDREJ	2.32e-04	10	80	2	16805797
Pubmed	Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.	CLSTN3 NETO1 LAMP5 ECT2 CIT NPAS1	2.35e-04	376	80	6	24154525
Pubmed	Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.	ACACA EI24 ITPR1	3.14e-04	57	80	3	17208939
Pubmed	Identification of epilepsy genes in human and mouse.	MYO5A ITPR1	3.40e-04	12	80	2	11700294
Pubmed	A model for p53-induced apoptosis.	PTGES EI24	3.40e-04	12	80	2	9305847
Pubmed	Targeted deletion of kidney glucose-6 phosphatase leads to nephropathy.	MLXIPL ACACA	3.40e-04	12	80	2	24717294
Pubmed	Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring.	MLXIPL ACACA	4.67e-04	14	80	2	25249504
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	CERS5 HDAC6 CSGALNACT2 ACACA JAGN1 OSBPL9 GBE1 CHID1 MTCH2 STT3A ITPR1	4.79e-04	1451	80	11	30550785
Pubmed	Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma.	DSC1 MYO5A ANAPC5	5.05e-04	67	80	3	29863498
Pubmed	Efficient and fast targeted production of murine models based on ENU mutagenesis.	GBE1 BPIFA1	5.38e-04	15	80	2	16075367
Pubmed	The finished DNA sequence of human chromosome 12.	FAM186A HIGD1C CIT	5.50e-04	69	80	3	16541075
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CLSTN3 HDAC6 MYO5A NETO1 PEG10 ABCC5 CUL9 PARVB TUBGCP5 CIT	7.21e-04	1285	80	10	35914814
Pubmed	Adiponectin enhances mouse fetal fat deposition.	MLXIPL ACACA	9.66e-04	20	80	2	22872236
Pubmed	Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity.	PTGES EI24	1.07e-03	21	80	2	21040902
Pubmed	Systematic identification of pathological lamin A interactors.	CSGALNACT2 ZNF569 JAGN1 AIG1 CLN6	1.10e-03	337	80	5	24623722
Pubmed	Characterization and mapping of human genes encoding zinc finger proteins.	ZSCAN22 ZNF569	1.17e-03	22	80	2	1946370
Pubmed	Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).	MLXIPL ACACA	1.17e-03	22	80	2	20965718
Pubmed	Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes.	ZSCAN22 ZNF569	1.17e-03	22	80	2	1505991
Pubmed	A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.	CLSTN3 NETO1 TENM2	1.23e-03	91	80	3	28558017
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	ACACA MYO5A CIT CNOT1	1.24e-03	202	80	4	33005030
Pubmed	Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.	MLXIPL ACACA	1.28e-03	23	80	2	26508642
Pubmed	Dual Shp2 and Pten Deficiencies Promote Non-alcoholic Steatohepatitis and Genesis of Liver Tumor-Initiating Cells.	MLXIPL ACACA	1.28e-03	23	80	2	27974211
Pubmed	A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models.	CUL9 ANAPC5	1.40e-03	24	80	2	33705438
Pubmed	FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells.	ACACA OSBPL9 CNOT1 STT3A	1.48e-03	212	80	4	33462405
Pubmed	Common variants at ten loci influence QT interval duration in the QTGEN Study.	PLEKHG5 CNOT1	1.51e-03	25	80	2	19305408
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	ACACA OSBPL9 CACNA1G ECT2 ITPR1	1.53e-03	363	80	5	14691545
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	HDAC6 MED16 PHF21A	1.57e-03	99	80	3	34161765
Pubmed	Control of TurboID-dependent biotinylation intensity in proximity ligation screens.	CERS5 CIT ITPR1	1.61e-03	100	80	3	36966971
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	ACACA NBEAL1 EI24 ABCC5 TENM2 ITPR1	1.73e-03	552	80	6	10737800
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	CERS5 CERS6	1.77e-03	27	80	2	23096701
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	CERS5 CERS6	1.77e-03	27	80	2	25269881
Pubmed	HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.	DSC1 ACACA EI24 CACNA1G MTCH2 STT3A ITPR1	1.77e-03	754	80	7	35906200
Pubmed	Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.	NBEAL1 JAGN1 EI24 OSBPL9 ADCY9 ITPR1	2.00e-03	568	80	6	37774976
Pubmed	Regulation of meiotic telomere dynamics through membrane fluidity promoted by AdipoR2-ELOVL2.	CERS5 CERS6	2.04e-03	29	80	2	38485951
Pubmed	Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.	CHRNA5 ITPR1	2.18e-03	30	80	2	22837378
Cytoband	12q13.12	CERS5 FAM186A HIGD1C	4.11e-05	38	80	3	12q13.12
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	ATG101 CERS5 FAM186A OR10AD1 HIGD1C	8.85e-04	423	80	5	chr12q13
Cytoband	18q23	ATP9B SMIM21	1.18e-03	29	80	2	18q23
Cytoband	Ensembl 112 genes in cytogenetic band chr18q23	ATP9B SMIM21	2.24e-03	40	80	2	chr18q23
Cytoband	15q23	IQCH CLN6	2.71e-03	44	80	2	15q23
Cytoband	17q22	KIF2B CACNA1G	2.71e-03	44	80	2	17q22
GeneFamily	CERS class homeoboxes	CERS5 CERS6	1.21e-04	6	52	2	530
Disease	pack-years measurement	TENM2 CHRNA5	2.01e-05	3	77	2	EFO_0006526
Disease	non-alcoholic fatty liver disease (biomarker_via_orthology)	CIDEB MLXIPL ACACA	6.64e-04	65	77	3	DOID:0080208 (biomarker_via_orthology)
Disease	syndrome (implicated_via_orthology)	SLC10A7 CNOT1	1.00e-03	18	77	2	DOID:225 (implicated_via_orthology)
Disease	Colorectal Carcinoma	CLSTN3 ACACA DUSP21 ZNF569 FSTL5 ABCC5 EDRF1	2.38e-03	702	77	7	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
LTHLRFMSHVVIGVL	ABCG4	391	Q9H172
TVLPFILIEMRTSHH	AIG1	136	Q9NVV5
LMVVLGLVRIHSLHR	CLSTN3	861	Q9BQT9
LALHIRSSMSGLHLV	ACACA	71	Q13085
RKDFLIMFVHHLVTI	CERS5	211	Q8N5B7
IMFVHHLVTIGLISF	CERS5	216	Q8N5B7
ILAVHSVHLMGYVHR	CIT	206	O14578
ITTKLGISGHVHRLM	SLC25A16	121	P16260
LITHPFHVITLRSMV	MTCH2	136	Q9Y6C9
GKIISHIIRHMDIVT	NBEAL1	2431	Q6ZS30
MIHGRSVLHIVASLI	NETO1	1	Q8TDF5
ELVRLVTLVHHMGGV	ECT2	191	Q9H8V3
QGVLMTFARHLFIIH	IQCH	961	Q86VS3
HGHMIVFRLSLGLTI	NPAS1	301	Q99742
HKSVIMHLLSQVRLG	OSBPL9	371	Q96SU4
VHKTSVVGLFLRHMI	ANAPC5	126	Q9UJX4
MLKIVFAGHEHLSLI	SLC10A7	286	Q0GE19
QMLIHLVVRDHIVSF	OR10AD1	81	Q8NGE0
LVAKMSVGHLRLLSH	JAGN1	51	Q8N5M9
GGRTFLRVLLHLTMH	ITPR1	1066	Q14643
SIHLIHMRVAAQGFV	HIGD1C	56	A8MV81
SHVSMAVHRIGRTLL	EDRF1	141	Q3B7T1
SITQFRHIGRLLMVH	ATP9B	906	O43861
QIHLAVAHMGVLVLR	FRMD7	201	Q6ZUT3
RHKILLHLGFIMASL	GPR137C	161	Q8N3F9
LVGSHIVPHMLRFTF	FER1L4	1021	A9Z1Z3
HISCVLVFHITVMGL	OR51B4	241	Q9Y5P0
LVFHITVMGLSFIHR	OR51B4	246	Q9Y5P0
KHTMIRLFVHEVLRV	DNAH12	2116	Q6ZR08
LAFMVSLGLVTHDHL	PHF21A	366	Q96BD5
VMLQIHLPGRHTLFV	PEG10	351	Q86TG7
GLVIMVTLAIYHVHH	LAMP5	246	Q9UJQ1
IMTRILHSTGLEFQH	TUBGCP5	901	Q96RT8
TTLIITHMRFGFILH	FSTL5	606	Q8N475
VHIVHRLSLQTMAVF	MED16	391	Q9Y2X0
LGGAVHLMVVLHTLL	PPP4R3C	431	Q6ZMV5
AILHLLVSLAMHFRA	PARVB	181	Q9HBI1
VISLLFLAVMYVVHH	ITPRIPL1	11	Q6GPH6
MLTIAHRLHTVLGSD	ABCC5	1381	O15440
HRLHTVLGSDRIMVL	ABCC5	1386	O15440
LTVIRHHLAFQMGVI	NBPF3	616	Q9H094
LSIMVTVFAINIHHR	CHRNA5	326	P30532
MLAVLHTVLLHRSTG	ATG101	21	Q9BSB4
LGMLVFREEIETHLH	CSGALNACT2	516	Q8N6G5
AHSMGIIVLLDVVHS	GBE1	276	Q04446
ITLVHDIVNMLIHGL	BPIFA1	236	Q9NP55
RTVITMGRDHILISH	DOCK2	921	Q92608
RIITHKMFDHVVLVI	CACNA1G	1271	O43497
SLLIFVRVLRSHVMV	GAS2L1	241	Q99501
IHLVGQLVSLLHMSL	EI24	196	O14681
VLITMFGQIHIRHRG	C1GALT1C1L	21	P0DN25
IHAIGVHLFVMSQVR	ADCY9	291	O60503
GIMFLHHLVSIFLIT	CERS6	206	Q6ZMG9
ITATLHIIMGHVQLV	CERKL	316	Q49MI3
IHMFLLARTHVKRIA	MC5R	206	P33032
RHGLVATHMLTVRVC	DSC1	651	Q08554
TLHMHRGVLVRQLTL	CUL9	1206	Q8IWT3
QLHTMARTLIIEILH	FAM186A	2131	A6NE01
HLTHLLMGLASGRII	HDAC6	761	Q9UBN7
LLVTSIQGHLVHMTV	CD48	21	P09326
VGALMLAALSHLHRF	PKD1L1	2656	Q8TDX9
LVIPTTLHLHMIFLR	BVES	56	Q8NE79
KRVGLIHMLTHLAEA	CHID1	201	Q9BWS9
LIHTIDMRQGRTLLH	DUSP21	91	Q9H596
HAVFQIILKSGRIMH	KIF2B	426	Q8N4N8
SGNVIIMTIIRLDHH	OR10J3	41	Q5JRS4
HAVSQVDHIMRIILG	PKDREJ	2041	Q9NTG1
LHVLVLMLTGRFSHR	STT3A	221	P46977
LIRVHLMVAVEGHLF	TENM2	1096	Q9NT68
MHFLVFLVGRVAHTV	PTGES	101	O14684
LLRSQVIHSGHFMVS	MLXIPL	41	Q9NP71
LMRQILEGVHFLHTR	STK17A	166	Q9UEE5
SIIIFIMGASIHLVG	CLN6	116	Q9NWW5
HMLLGISSTLRHAVE	CIDEB	191	Q9UHD4
HTLRHELISTLMPIF	CNOT1	496	A5YKK6
VVAMIGSVERFIHHV	PLEKHG5	511	O94827
LISLHALIMVGFHFL	ZDHHC3	181	Q9NYG2
RNRLMITHHAVILFV	TLCD3A	116	Q8TBR7
LVLFHVMVLLRNHSR	SMIM21	56	Q3B7S5
SSALMVHLRIHITVL	ZSCAN22	476	P10073
FSMLIIHVRIHTGEK	ZNF569	366	Q5MCW4
LVFIGIISVHCMHIL	SLC36A4	96	Q6YBV0
IHMTFGVILGIFNHL	ATP6V0A2	561	Q9Y487
HQMGIFRILAGILHL	MYO5A	321	Q9Y4I1