Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	TF_fork_head_CS_2	FOXD4L4 FOXD4L6 FOXD4L3	1.20e-04	46	39	3	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L4 FOXD4L6 FOXD4L3	1.28e-04	47	39	3	IPR018122
Domain	FORK_HEAD_3	FOXD4L4 FOXD4L6 FOXD4L3	1.45e-04	49	39	3	PS50039
Domain	FH	FOXD4L4 FOXD4L6 FOXD4L3	1.45e-04	49	39	3	SM00339
Domain	FORK_HEAD_1	FOXD4L4 FOXD4L6 FOXD4L3	1.45e-04	49	39	3	PS00657
Domain	FORK_HEAD_2	FOXD4L4 FOXD4L6 FOXD4L3	1.45e-04	49	39	3	PS00658
Domain	Forkhead	FOXD4L4 FOXD4L6 FOXD4L3	1.45e-04	49	39	3	PF00250
Domain	Fork_head_dom	FOXD4L4 FOXD4L6 FOXD4L3	1.45e-04	49	39	3	IPR001766
Domain	Alpha-crystallin/HSP	HSPB8 HSPB6	1.52e-04	9	39	2	IPR001436
Domain	HSP20	HSPB8 HSPB6	1.52e-04	9	39	2	IPR031107
Domain	A-crystallin/Hsp20_dom	HSPB8 HSPB6	2.31e-04	11	39	2	IPR002068
Domain	HSP20	HSPB8 HSPB6	2.31e-04	11	39	2	PF00011
Domain	HSP20	HSPB8 HSPB6	2.31e-04	11	39	2	PS01031
Domain	-	HSPB8 HSPB6	1.05e-03	23	39	2	2.60.40.790
Domain	HSP20-like_chaperone	HSPB8 HSPB6	1.34e-03	26	39	2	IPR008978
Domain	-	FOXD4L4 FOXD4L6 FOXD4L3	1.05e-02	218	39	3	1.10.10.10
Domain	WHTH_DNA-bd_dom	FOXD4L4 FOXD4L6 FOXD4L3	1.39e-02	242	39	3	IPR011991
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L4 FOXD4L6 FOXD4L3	3.51e-08	6	43	3	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L4 FOXD4L6 FOXD4L3	9.82e-08	8	43	3	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L4 FOXD4L6 FOXD4L3	1.47e-07	9	43	3	12412011
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L4 FOXD4L6 FOXD4L3	4.99e-07	13	43	3	7957066
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L4 FOXD4L6 FOXD4L3	4.99e-07	13	43	3	16884697
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L4 FOXD4L6 FOXD4L3	7.93e-07	15	43	3	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L4 FOXD4L6 FOXD4L3	7.93e-07	15	43	3	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L4 FOXD4L6 FOXD4L3	9.75e-07	16	43	3	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L4 FOXD4L6 FOXD4L3	9.75e-07	16	43	3	10208738
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L4 FOXD4L6 HIF3A FOXD4L3	1.47e-06	67	43	4	22711520
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L4 FOXD4L6 FOXD4L3	1.68e-06	19	43	3	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L4 FOXD4L6 FOXD4L3	1.98e-06	20	43	3	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L4 FOXD4L6 FOXD4L3	2.31e-06	21	43	3	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L4 FOXD4L6 FOXD4L3	2.67e-06	22	43	3	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L4 FOXD4L6 FOXD4L3	3.50e-06	24	43	3	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L4 FOXD4L6 FOXD4L3	3.50e-06	24	43	3	29992973
Pubmed	Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction.	HSPB8 HSPB6	4.48e-06	3	43	2	19845507
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L4 FOXD4L6 FOXD4L3	4.49e-06	26	43	3	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L4 FOXD4L6 FOXD4L3	6.29e-06	29	43	3	22972626
Pubmed	Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3.	HSPB8 HSPB6	8.94e-06	4	43	2	16225851
Pubmed	Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter.	HSPB8 HSPB6	8.94e-06	4	43	2	26694816
Pubmed	Expression of the small heat shock protein family in the mouse CNS: differential anatomical and biochemical compartmentalization.	HSPB8 HSPB6	8.94e-06	4	43	2	18384969
Pubmed	A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.	U2AF1L4 CEP131 GLCCI1 HSPB8	1.40e-05	118	43	4	30979931
Pubmed	HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes.	HSPB8 HSPB6	1.49e-05	5	43	2	21731611
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L4 FOXD4L6	1.49e-05	5	43	2	12234674
Pubmed	Inhibition of α-synuclein aggregation by small heat shock proteins.	HSPB8 HSPB6	2.23e-05	6	43	2	21905118
Pubmed	HSPB7 is a SC35 speckle resident small heat shock protein.	HSPB8 HSPB6	5.35e-05	9	43	2	19464326
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	FBRSL1 TRNP1 FAM89A CEP131 LZTR1 GAREM2 PLEKHO2 AHDC1	5.46e-05	1105	43	8	35748872
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L3	8.15e-05	11	43	2	12421752
Pubmed	Guanylate binding protein 1-mediated interaction of T cell antigen receptor signaling with the cytoskeleton.	PTPRC YBX1	8.15e-05	11	43	2	24337748
Pubmed	Insights into function and regulation of small heat shock protein 25 (HSPB1) in a mouse model with targeted gene disruption.	HSPB8 HSPB6	1.15e-04	13	43	2	17661394
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PARP10 ACOT2 AXIN1 NPC1L1	1.97e-04	233	43	4	37704626
Pubmed	H-2 haplotypes, genes, and antigens: second listing. I. Non-H-2 loci on chromosome 17.	MAN2A1 AXIN1	2.01e-04	17	43	2	6816725
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	FBRSL1 YBX1 C2orf68 GLCCI1 CNOT3 HSPB8 AXIN1	2.61e-04	1038	43	7	26673895
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	FOXD4L4 FOXD4L3	3.40e-04	22	43	2	15233989
Pubmed	Conserved beta-hairpin recognition by the GYF domains of Smy2 and GIGYF2 in mRNA surveillance and vesicular transport complexes.	U2AF1L4 YBX1	3.72e-04	23	43	2	20696395
Cytoband	9q21.11	FOXD4L4 FOXD4L6 FOXD4L3	3.05e-06	30	43	3	9q21.11
GeneFamily	Small heat shock proteins	HSPB8 HSPB6	9.22e-05	11	24	2	585
GeneFamily	Sulfotransferases, membrane bound	CHST12 CHST2	1.09e-03	37	24	2	763
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	AXIN1 HSPB6	2.38e-02	181	24	2	694
Disease	systemic lupus erythematosus (implicated_via_orthology)	MAN2A1 PTPRC	1.13e-03	43	34	2	DOID:9074 (implicated_via_orthology)
Disease	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	PTPRC CNOT3	1.71e-03	53	34	2	C1961099
Disease	cardiovascular disease	FBRSL1 APOLD1 AXIN1 NPC1L1	1.82e-03	457	34	4	EFO_0000319
Disease	irritable bowel syndrome symptom measurement	FAM89A APOLD1	2.05e-03	58	34	2	EFO_0021536
Disease	osteoporosis	DDN AXIN1	3.22e-03	73	34	2	EFO_0003882

Protein segments in the cluster

Peptide	Gene	Start	Entry
LEPPERPYRDREPHG	FBRSL1	921	Q9HCM7
RPYRDREPHGYSPER	FBRSL1	926	Q9HCM7
IPLHGRPIYPNRRER	C2orf80	71	Q0P641
REHEGRLRYPSRREP	CLK3	176	P49761
RHERYFLPPGVRREP	ACOT2	186	P49753
IPDGRRAPLPAHYRS	GLCCI1	326	Q86VQ1
PEGHPKYALRRTDRP	AHDC1	376	Q5TGY3
RRPGPPSYEAHLLLR	DDN	196	O94850
RPRKPDLQVYLPRHR	C2orf68	61	Q2NKX9
PHPSDSERIRQYLPR	CNOT3	626	O75175
RPEGGRPHREKYPRS	RBM20	726	Q5T481
RPAAREPHGPDALRR	APOLD1	36	Q96LR9
EFHRRYRLPPGVDPA	HSPB6	116	O14558
EHLLRGSPPPPQRRY	LZTR1	271	Q8N653
LDRGHLDYPRNPRRE	MAN2A1	26	Q16706
GRRPYALLHPHPLRY	FOXD4L4	256	Q8WXT5
GRRPYALLHPHPLRY	FOXD4L3	256	Q6VB84
HYPSRLRRDPFRDSP	HSPB8	11	Q9UJY1
LSPRFRGEHALRRYP	NDUFS8	91	O00217
YQRLPRRPGEPREVH	NPC1L1	721	Q9UHC9
YTLVRPHRPARPRPV	CARD14	816	Q9BXL6
DGIPPYRIRKQHRRE	AXIN1	341	O15169
PPPRVVSEEHLRRYA	CHIC1	71	Q5VXU3
PDVLPRPRTHHRGRY	CEP131	471	Q9UPN4
RAPPLRGPGHVLLRY	PARP10	961	Q53GL7
SRPPRNPYDLHPVRE	GAREM2	271	Q75VX8
ERHRPTDGPRLYRPA	RASL10A	31	Q92737
EGHLERPAYVPRKPR	TMC3	1001	Q7Z5M5
HDRRDRGPPRDLSLP	FAM89A	156	Q96GI7
GRRPYALLHPHPLRY	FOXD4L6	256	Q3SYB3
AYHRPLGAVPRPRAR	HIF3A	511	Q9Y2N7
AHARLDLRTPYRPPA	CHST2	116	Q9Y4C5
HRGAPYRDPLRIPRE	CHST12	191	Q9NRB3
RVRYPGPHPRRAVEP	LINC01465	56	Q8N7H1
APAGERRIYRHRIPS	ZNF511	216	Q8NB15
DRNHYRRYPRRRGPP	YBX1	141	P67809
YGRGPRRRSPPRFHT	U2AF1L4	186	Q8WU68
RGDRDPPVLFRHYPD	ZNF688	256	P0C7X2
GEGPRHPLQPRERLY	PLEKHO2	396	Q8TD55
GPYREDPRIHRHLAR	UPK3B	206	Q9BT76
RPPRDRNGPHERYHL	PTPRC	506	P08575
RLRRGHGPEPDSPFR	TRNP1	201	Q6NT89
KYGRPDPLLRREHDI	VPS13D	1951	Q5THJ4
ELAYRRRPPRSPDHK	GRIN2B	1106	Q13224
RRPPRSPDHKRYFRD	GRIN2B	1111	Q13224