Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase binding	BIRC8 NAIP PRKCH	4.06e-05	24	56	3	GO:0120283
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	TRPA1 GRIK1 RYR2	8.88e-05	31	56	3	GO:0099604
GeneOntologyBiologicalProcess	lymph circulation	HEG1 SVEP1	7.24e-06	2	56	2	GO:0003017
GeneOntologyBiologicalProcess	epithelial cell-cell adhesion	KIFC3 ITGB5 SVEP1	1.50e-05	18	56	3	GO:0090136
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LRP2 LDLR	7.20e-05	5	56	2	GO:1905167
GeneOntologyCellularComponent	Z disc	CSRP1 OBSCN OBSL1 FHL5 RYR2	5.22e-05	151	56	5	GO:0030018
GeneOntologyCellularComponent	I band	CSRP1 OBSCN OBSL1 FHL5 RYR2	8.19e-05	166	56	5	GO:0031674
GeneOntologyCellularComponent	receptor complex	LRP2 LOXL4 GRIK1 ITGAE ITGB5 LDLR PTH1R NOTCH2	1.49e-04	581	56	8	GO:0043235
GeneOntologyCellularComponent	supramolecular fiber	CYLD KIF21B FBN2 EFCAB6 CSRP1 OBSCN OBSL1 KIFC3 CAMSAP2 FHL5 RYR2	2.50e-04	1179	56	11	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	CYLD KIF21B FBN2 EFCAB6 CSRP1 OBSCN OBSL1 KIFC3 CAMSAP2 FHL5 RYR2	2.65e-04	1187	56	11	GO:0099081
GeneOntologyCellularComponent	cluster of actin-based cell projections	TMPRSS15 TRPA1 PJVK LRP2 PTH1R	3.24e-04	223	56	5	GO:0098862
GeneOntologyCellularComponent	A band	OBSCN OBSL1 RYR2	3.67e-04	52	56	3	GO:0031672
GeneOntologyCellularComponent	side of membrane	CYLD HEG1 VWF LRP2 TECTA ITGAE LDLR RECK RYR2	4.89e-04	875	56	9	GO:0098552
GeneOntologyCellularComponent	sarcomere	CSRP1 OBSCN OBSL1 FHL5 RYR2	5.36e-04	249	56	5	GO:0030017
GeneOntologyCellularComponent	myofibril	CSRP1 OBSCN OBSL1 FHL5 RYR2	8.12e-04	273	56	5	GO:0030016
GeneOntologyCellularComponent	cell-cell junction	HEG1 OBSCN OBSL1 LAMA3 PRKCH KIFC3 AJUBA	9.72e-04	591	56	7	GO:0005911
GeneOntologyCellularComponent	contractile muscle fiber	CSRP1 OBSCN OBSL1 FHL5 RYR2	1.06e-03	290	56	5	GO:0043292
GeneOntologyCellularComponent	anchoring junction	HEG1 CSRP1 OBSCN OBSL1 LAMA3 PRKCH KIFC3 AJUBA ITGB5	1.07e-03	976	56	9	GO:0070161
GeneOntologyCellularComponent	cell surface	EPHB6 HEG1 VWF LRP2 IL17RC ITGAE ITGB5 LDLR NOTCH2	2.60e-03	1111	56	9	GO:0009986
GeneOntologyCellularComponent	M band	OBSCN OBSL1	3.12e-03	31	56	2	GO:0031430
GeneOntologyCellularComponent	integrin complex	ITGAE ITGB5	3.32e-03	32	56	2	GO:0008305
Domain	EGF	HEG1 FBN2 LRP2 LAMA3 NRG2 TECTA ITGB5 LDLR SVEP1 NOTCH2	1.46e-09	235	55	10	SM00181
Domain	EGF-like_dom	HEG1 FBN2 LRP2 LAMA3 NRG2 TECTA LDLR SVEP1 NOTCH2	4.29e-08	249	55	9	IPR000742
Domain	EGF_1	HEG1 FBN2 LRP2 LAMA3 NRG2 ITGB5 LDLR SVEP1 NOTCH2	5.26e-08	255	55	9	PS00022
Domain	EGF-like_CS	HEG1 FBN2 LRP2 LAMA3 NRG2 ITGB5 LDLR SVEP1 NOTCH2	6.42e-08	261	55	9	IPR013032
Domain	EGF_2	HEG1 FBN2 LRP2 LAMA3 NRG2 ITGB5 LDLR SVEP1 NOTCH2	7.32e-08	265	55	9	PS01186
Domain	EGF	HEG1 LRP2 NRG2 TECTA ITGB5 SVEP1 NOTCH2	8.34e-08	126	55	7	PF00008
Domain	EGF_CA	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	1.93e-07	86	55	6	PF07645
Domain	Growth_fac_rcpt_	EPHB6 FBN2 LRP2 LAMA3 LDLR SVEP1 NOTCH2	3.59e-07	156	55	7	IPR009030
Domain	EGF_Ca-bd_CS	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	3.96e-07	97	55	6	IPR018097
Domain	EGF_CA	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	4.47e-07	99	55	6	PS01187
Domain	ASX_HYDROXYL	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	4.75e-07	100	55	6	PS00010
Domain	EGF-type_Asp/Asn_hydroxyl_site	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	6.70e-07	106	55	6	IPR000152
Domain	EGF_CA	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	1.53e-06	122	55	6	SM00179
Domain	EGF-like_Ca-bd_dom	HEG1 FBN2 LRP2 LDLR SVEP1 NOTCH2	1.68e-06	124	55	6	IPR001881
Domain	EGF_3	HEG1 FBN2 LRP2 NRG2 LDLR SVEP1 NOTCH2	5.54e-06	235	55	7	PS50026
Domain	TIL_dom	VWF LRP2 TECTA	8.60e-06	14	55	3	IPR002919
Domain	hEGF	FBN2 SVEP1 NOTCH2	7.51e-05	28	55	3	PF12661
Domain	VWFA	VWF ITGAE ITGB5 SVEP1	9.93e-05	82	55	4	PS50234
Domain	VWA	VWF ITGAE ITGB5 SVEP1	1.09e-04	84	55	4	SM00327
Domain	VWF_A	VWF ITGAE ITGB5 SVEP1	2.06e-04	99	55	4	IPR002035
Domain	LDLR_class-A_CS	TMPRSS15 LRP2 LDLR	2.21e-04	40	55	3	IPR023415
Domain	BIR	BIRC8 NAIP	2.36e-04	8	55	2	SM00238
Domain	-	BIRC8 NAIP	2.36e-04	8	55	2	1.10.1170.10
Domain	BIR	BIRC8 NAIP	2.36e-04	8	55	2	PF00653
Domain	BIR_REPEAT_2	BIRC8 NAIP	2.36e-04	8	55	2	PS50143
Domain	BIR_rpt	BIRC8 NAIP	2.36e-04	8	55	2	IPR001370
Domain	BIR_REPEAT_1	BIRC8 NAIP	2.36e-04	8	55	2	PS01282
Domain	Ldl_recept_a	TMPRSS15 LRP2 LDLR	3.14e-04	45	55	3	PF00057
Domain	-	TMPRSS15 LRP2 LDLR	3.35e-04	46	55	3	4.10.400.10
Domain	LDLRA_1	TMPRSS15 LRP2 LDLR	3.81e-04	48	55	3	PS01209
Domain	LDLRA_2	TMPRSS15 LRP2 LDLR	4.04e-04	49	55	3	PS50068
Domain	LDrepeatLR_classA_rpt	TMPRSS15 LRP2 LDLR	4.04e-04	49	55	3	IPR002172
Domain	LDLa	TMPRSS15 LRP2 LDLR	4.04e-04	49	55	3	SM00192
Domain	ConA-like_dom	TMPRSS15 TRIM25 LAMA3 SVEP1 RYR2	4.57e-04	219	55	5	IPR013320
Domain	Ephrin_rec_like	EPHB6 SVEP1	4.60e-04	11	55	2	PF07699
Domain	TIL	VWF TECTA	5.51e-04	12	55	2	PF01826
Domain	C8	VWF TECTA	5.51e-04	12	55	2	PF08742
Domain	VWA	VWF ITGAE SVEP1	6.00e-04	56	55	3	PF00092
Domain	Unchr_dom_Cys-rich	VWF TECTA	6.50e-04	13	55	2	IPR014853
Domain	C8	VWF TECTA	6.50e-04	13	55	2	SM00832
Domain	EGF_extracell	LRP2 ITGB5 SVEP1	7.34e-04	60	55	3	IPR013111
Domain	EGF_2	LRP2 ITGB5 SVEP1	7.34e-04	60	55	3	PF07974
Domain	Ldl_recept_b	LRP2 LDLR	7.57e-04	14	55	2	PF00058
Domain	LDLRB	LRP2 LDLR	7.57e-04	14	55	2	PS51120
Domain	LY	LRP2 LDLR	8.72e-04	15	55	2	SM00135
Domain	LDLR_classB_rpt	LRP2 LDLR	8.72e-04	15	55	2	IPR000033
Domain	VWD	VWF TECTA	9.95e-04	16	55	2	SM00216
Domain	VWF_type-D	VWF TECTA	9.95e-04	16	55	2	IPR001846
Domain	VWFD	VWF TECTA	9.95e-04	16	55	2	PS51233
Domain	VWD	VWF TECTA	9.95e-04	16	55	2	PF00094
Domain	LIM	CSRP1 AJUBA FHL5	1.10e-03	69	55	3	PF00412
Domain	-	CSRP1 AJUBA FHL5	1.15e-03	70	55	3	2.10.110.10
Domain	Znf_LIM	CSRP1 AJUBA FHL5	1.20e-03	71	55	3	IPR001781
Domain	LIM_DOMAIN_1	CSRP1 AJUBA FHL5	1.20e-03	71	55	3	PS00478
Domain	LIM_DOMAIN_2	CSRP1 AJUBA FHL5	1.20e-03	71	55	3	PS50023
Domain	LIM	CSRP1 AJUBA FHL5	1.20e-03	71	55	3	SM00132
Domain	-	VWF ITGB5 SVEP1	1.35e-03	74	55	3	3.40.50.410
Domain	VWC_out	VWF TECTA	1.41e-03	19	55	2	SM00215
Domain	SRCR	TMPRSS15 LOXL4	1.72e-03	21	55	2	PF00530
Domain	Ephrin_rec_like	EPHB6 SVEP1	2.45e-03	25	55	2	SM01411
Domain	SR	TMPRSS15 LOXL4	2.45e-03	25	55	2	SM00202
Domain	Integrin_dom	ITGAE ITGB5	2.45e-03	25	55	2	IPR032695
Domain	-	TMPRSS15 LOXL4	2.45e-03	25	55	2	3.10.250.10
Domain	Tyr-kin_ephrin_A/B_rcpt-like	EPHB6 SVEP1	2.45e-03	25	55	2	IPR011641
Domain	SRCR_1	TMPRSS15 LOXL4	2.64e-03	26	55	2	PS00420
Domain	cEGF	FBN2 LRP2	2.64e-03	26	55	2	IPR026823
Domain	SRCR_2	TMPRSS15 LOXL4	2.64e-03	26	55	2	PS50287
Domain	cEGF	FBN2 LRP2	2.64e-03	26	55	2	PF12662
Domain	SRCR-like_dom	TMPRSS15 LOXL4	2.64e-03	26	55	2	IPR017448
Domain	SRCR	TMPRSS15 LOXL4	2.85e-03	27	55	2	IPR001190
Domain	EF-hand_8	EFCAB6 RYR2	4.50e-03	34	55	2	PF13833
Domain	VWC	VWF TECTA	5.59e-03	38	55	2	SM00214
Domain	VWFC_2	VWF TECTA	5.59e-03	38	55	2	PS50184
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP2 LOXL4 ITGB5 LDLR NOTCH2	6.35e-07	101	56	5	23382219
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	EPHB6 CYLD AARS1 VWF SF3B1 OBSL1 LRP2 TMEM131 GRIK1 PRKDC KIFC3 RECK	7.62e-07	1285	56	12	35914814
Pubmed	Cutaneous inflammatory disorder in integrin alphaE (CD103)-deficient mice.	PRKDC ITGAE	2.55e-06	2	56	2	11086102
Pubmed	Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice.	MSTN LDLR	2.55e-06	2	56	2	19509018
Pubmed	Central tolerance spares the private high-avidity CD4(+) T-cell repertoire specific for an islet antigen in NOD mice.	PRSS16 PRKDC	2.55e-06	2	56	2	25884569
Pubmed	Investigating the complex interplay between genotype and high-fat-diet feeding in the lactating mammary gland using the Tph1 and Ldlr knockout models.	LDLR TPH1	2.55e-06	2	56	2	33427054
Pubmed	TRPA1 is a substrate for de-ubiquitination by the tumor suppressor CYLD.	CYLD TRPA1	2.55e-06	2	56	2	16500080
Pubmed	Microtubule Minus-End Binding Protein CAMSAP2 and Kinesin-14 Motor KIFC3 Control Dendritic Microtubule Organization.	KIFC3 CAMSAP2	2.55e-06	2	56	2	32084403
Pubmed	Thymus-specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice.	PRSS16 PRKDC	2.55e-06	2	56	2	21505262
Pubmed	Thymic-Specific Serine Protease Limits Central Tolerance and Exacerbates Experimental Autoimmune Encephalomyelitis.	PRSS16 PRKDC	2.55e-06	2	56	2	29061767
Pubmed	Localized reduction of atherosclerosis in von Willebrand factor-deficient mice.	VWF LDLR	2.55e-06	2	56	2	11520791
Pubmed	Hypercholesterolemia induces T cell expansion in humanized immune mice.	PRKDC LDLR	2.55e-06	2	56	2	29708512
Pubmed	PTH/PTHrP Receptor Signaling Restricts Arterial Fibrosis in Diabetic LDLR-/- Mice by Inhibiting Myocardin-Related Transcription Factor Relays.	LDLR PTH1R	7.63e-06	3	56	2	32160132
Pubmed	Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis.	LDLR PTH1R	7.63e-06	3	56	2	20489161
Pubmed	GANP regulates the choice of DNA repair pathway by DNA-PKcs interaction in AID-dependent IgV region diversification.	MCM3AP PRKDC	7.63e-06	3	56	2	24808370
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	7.63e-06	3	56	2	20133654
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	7.63e-06	3	56	2	27989621
Pubmed	Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.	OBSCN OBSL1	7.63e-06	3	56	2	31098411
Pubmed	Variants in DNA double-strand break repair and DNA damage-response genes and susceptibility to lung and head and neck cancers.	RAD52 PRKDC	7.63e-06	3	56	2	18449888
Pubmed	Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis-Brief Report.	LRP2 LDLR	7.63e-06	3	56	2	30567480
Pubmed	A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection.	PRKDC ITGAE	7.63e-06	3	56	2	15845457
Pubmed	Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.	OBSCN OBSL1	7.63e-06	3	56	2	20489725
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	FBN2 MCM3AP CAMSAP2 LDLR NOTCH2	1.20e-05	184	56	5	32908313
Pubmed	A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism.	PRKDC ITGAE	1.52e-05	4	56	2	17620361
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LRP2 LDLR	2.54e-05	5	56	2	18685438
Pubmed	Genetic causes of nonsyndromic hearing loss in Iran in comparison with other populations.	PJVK TECTA	2.54e-05	5	56	2	20739942
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	CYLD SF3B1 EFCAB6 PRKCH PRKDC NUP160 NOTCH2 RYR2	3.30e-05	777	56	8	35844135
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LRP2 LDLR	3.80e-05	6	56	2	9837937
Pubmed	Functional proteomics mapping of a human signaling pathway.	FBN2 VWF SF3B1 MCM3AP SVEP1 NOTCH2 RYR2	4.45e-05	591	56	7	15231748
Pubmed	The inhibitors of apoptosis: there is more to life than Bcl2.	BIRC8 NAIP	5.32e-05	7	56	2	14634619
Pubmed	RAD52 polymorphisms contribute to the development of papillary thyroid cancer susceptibility in Middle Eastern population.	RAD52 PRKDC	5.32e-05	7	56	2	19092295
Pubmed	The inhibitors of apoptosis (IAPs) and their emerging role in cancer.	BIRC8 NAIP	5.32e-05	7	56	2	9916987
Pubmed	IAP family proteins--suppressors of apoptosis.	BIRC8 NAIP	5.32e-05	7	56	2	9990849
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LRP2 LDLR	5.32e-05	7	56	2	12169628
Pubmed	Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.	ITGAE LDLR	5.32e-05	7	56	2	30700910
Pubmed	Targeting of bone morphogenetic protein growth factor complexes to fibrillin.	FBN2 MSTN	7.09e-05	8	56	2	18339631
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	FBN2 VWF	9.10e-05	9	56	2	12122015
Pubmed	Confirmation of quantitative trait loci for cocaine-induced activation in the AcB/BcA series of recombinant congenic strains.	GRIK1 TPH1	9.10e-05	9	56	2	12777963
Pubmed	The gut-to-brain axis for toxin-induced defensive responses.	TRPA1 TPH1	1.14e-04	10	56	2	36323317
Pubmed	A human MAP kinase interactome.	VWF SF3B1 MCM3AP LAMA3 PRKCH PRKDC	1.30e-04	486	56	6	20936779
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	LAMA3 TMEM131 ITGB5 LDLR	1.45e-04	164	56	4	32409323
Pubmed	Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.	KIF21B GRIK1 POLR1H	1.61e-04	65	56	3	23453885
Pubmed	Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis.	TRPA1 TPH1	1.66e-04	12	56	2	33220232
Pubmed	Evidence for complex multigenic inheritance of radiation AML susceptibility in mice revealed using a surrogate phenotypic assay.	MTF1 LAMA3	1.96e-04	13	56	2	16093251
Pubmed	Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.	BIRC8 TRPA1	1.96e-04	13	56	2	35263589
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF NOTCH2	1.96e-04	13	56	2	20558824
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	AARS1 TRIM25 SF3B1 PRKDC NUP160	1.97e-04	332	56	5	32786267
Pubmed	Stage-specific association of apolipoprotein A-I and E in developing mouse retina.	LRP2 LDLR	2.29e-04	14	56	2	17389516
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	MCM3AP PRKDC NUP160	2.66e-04	77	56	3	24927568
Pubmed	Integrin requirement for hippocampal synaptic plasticity and spatial memory.	ITGAE ITGB5	3.01e-04	16	56	2	12904471
Pubmed	Regulation of ubiquitin-proteasome system-mediated Tip110 protein degradation by USP15.	SF3B1 NUP160	3.01e-04	16	56	2	24984263
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	HEG1 MCM3AP OBSCN PRKDC KIFC3 ITGB5 LDLR NOTCH2	3.72e-04	1105	56	8	35748872
Pubmed	Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.	LRP2 LDLR	3.83e-04	18	56	2	10827173
Pubmed	Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder.	GRIK1 TPH1	4.28e-04	19	56	2	19095219
Pubmed	Genetic loci controlling body fat, lipoprotein metabolism, and insulin levels in a multifactorial mouse model.	LRP2 LDLR	5.24e-04	21	56	2	9616220
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP2 LDLR	5.24e-04	21	56	2	21337463
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RAD52 NAIP OBSCN LAMA3 GRIK1 TECTA ITGB5 RECK NOTCH2	5.81e-04	1489	56	9	28611215
Pubmed	Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.	GRIK1 LDLR	6.30e-04	23	56	2	8464923
Pubmed	IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice.	TRPA1 PRKDC	6.30e-04	23	56	2	34473953
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FBN2 SF3B1 LOXL4 PRKDC ITGB5 LDLR NUP160 NOTCH2	6.51e-04	1203	56	8	29180619
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	OBSCN RYR2	7.46e-04	25	56	2	38877142
Pubmed	ERp57 is essential for efficient folding of glycoproteins sharing common structural domains.	ITGB5 LDLR	7.46e-04	25	56	2	17170699
Pubmed	Nuclear organization of nucleotide excision repair is mediated by RING1B dependent H2A-ubiquitylation.	SF3B1 MTF1 PRKDC	7.96e-04	112	56	3	28416769
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN2 LAMA3	8.07e-04	26	56	2	34189436
Pubmed	Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.	RAD52 PRKDC	8.71e-04	27	56	2	20610542
Pubmed	Perlecan regulates pericyte dynamics in the maintenance and repair of the blood-brain barrier.	ITGAE ITGB5	8.71e-04	27	56	2	31541017
Pubmed	New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.	TRIM25 OBSL1 TMEM131 KLHDC10 RYR2	8.86e-04	462	56	5	31138677
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	MSTN LDLR PTH1R TPH1	1.02e-03	275	56	4	20734064
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	AARS1 SF3B1 EIF5 PRKDC KLHDC10 LDLR NUP160 NOTCH2	1.06e-03	1297	56	8	33545068
Pubmed	Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.	BIRC8 VWF	1.08e-03	30	56	2	17699753
Pubmed	Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.	LRP2 LDLR	1.15e-03	31	56	2	20031551
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	SF3B1 PRKDC NUP160	1.17e-03	128	56	3	23858473
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	EPHB6 OBSL1 LOXL4 GRIK1 ITGB5	1.21e-03	496	56	5	31343991
Pubmed	Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.	LAMA3 ITGB5	1.22e-03	32	56	2	23154389
Pubmed	Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.	SF3B1 PRKDC	1.38e-03	34	56	2	11101529
Pubmed	Hypertrophic Cardiomyopathy Overview	OBSCN RYR2	1.38e-03	34	56	2	20301725
Pubmed	Control of endodermal endocrine development by Hes-1.	NOTCH2 TPH1	1.38e-03	34	56	2	10615124
Pubmed	The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.	ITGB5 NOTCH2	1.46e-03	35	56	2	28402857
Pubmed	L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.	VWF PTH1R RYR2	1.61e-03	143	56	3	20424473
Interaction	ZFP41 interactions	FBN2 TRIM25 LRP2 LDLR NOTCH2	5.18e-07	57	56	5	int:ZFP41
Interaction	NTN5 interactions	FBN2 LRP2 LDLR NOTCH2	5.45e-07	24	56	4	int:NTN5
Interaction	IGFL3 interactions	FBN2 LRP2 LAMA3 LDLR NOTCH2	2.05e-06	75	56	5	int:IGFL3
Interaction	GREM2 interactions	FBN2 LRP2 LDLR NOTCH2	3.30e-06	37	56	4	int:GREM2
Interaction	TRIM33 interactions	CYLD FBN2 TRIM25 SF3B1 ZIM2 LRP2 LOXL4 PRKDC AJUBA	4.02e-06	453	56	9	int:TRIM33
Interaction	PRG3 interactions	FBN2 ITGB5 LDLR NOTCH2	1.03e-05	49	56	4	int:PRG3
Interaction	FOXD4L6 interactions	FBN2 MCM3AP LDLR NOTCH2	1.03e-05	49	56	4	int:FOXD4L6
Interaction	DEFB125 interactions	FBN2 LRP2 LAMA3	2.24e-05	20	56	3	int:DEFB125
Interaction	PDIA4 interactions	EPHB6 FBN2 VWF TRIM25 OBSL1 LRP2 TMEM131 LDLR	4.26e-05	468	56	8	int:PDIA4
Interaction	ZNF408 interactions	FBN2 LRP2 LDLR FHL5 NOTCH2	5.12e-05	145	56	5	int:ZNF408
Interaction	TRPA1 interactions	CYLD TRPA1	7.54e-05	5	56	2	int:TRPA1
Cytoband	3q21.2	HEG1 ITGB5	3.02e-04	21	56	2	3q21.2
Cytoband	1q42.13	OBSCN PGBD5	1.66e-03	49	56	2	1q42.13
Cytoband	Ensembl 112 genes in cytogenetic band chr1q32	KIF21B CSRP1 CAMSAP2	5.40e-03	290	56	3	chr1q32
Cytoband	1q32.1	KIF21B CAMSAP2	7.77e-03	108	56	2	1q32.1
GeneFamily	Ring finger proteins\|Baculoviral IAP repeat containing\|Caspase recruitment domain containing	BIRC8 NAIP	1.26e-04	8	39	2	419
GeneFamily	LIM domain containing	CSRP1 AJUBA FHL5	2.77e-04	59	39	3	1218
GeneFamily	Low density lipoprotein receptors	LRP2 LDLR	3.48e-04	13	39	2	634
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF21B KIFC3	4.42e-03	46	39	2	622
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	OBSCN OBSL1 NRG2	5.01e-03	161	39	3	593
GeneFamily	Proteases, serine	TMPRSS15 PRSS16	8.15e-03	63	39	2	738
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 FBN2 EFCAB6 OBSCN LRP2 RYR2	1.18e-07	184	56	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 FBN2 EFCAB6 OBSCN LRP2 RYR2	1.18e-07	184	56	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMPRSS15 FBN2 EFCAB6 OBSCN LRP2 RYR2	1.18e-07	184	56	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 FBN2 OBSCN OPN5 GRIK1 ITGB5	1.43e-07	190	56	6	3b8d1e66ae68c1eee64095e75195d76d97e24026
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 FBN2 OBSCN OPN5 GRIK1 ITGB5	1.43e-07	190	56	6	dc655e4782aab274f0c9b6e36a5ce315e3a1a4b9
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SLC25A41 CSRP1 KLHDC10 RECK TPH1	1.24e-06	149	56	5	68661c8facfb638560bb2e2c20d509941286dacb
ToppCell	368C-Myeloid-Monocyte-CD16+_Monocyte\|368C / Donor, Lineage, Cell class and subclass (all cells)	FBN2 TRIM25 EFCAB6 MCM3AP LRP2	1.56e-06	156	56	5	25b0936960be4955b6a6d6b8a867fdd4be548f05
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 LRP2 TECTA SVEP1 RYR2	1.76e-06	160	56	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 LRP2 TECTA SVEP1 RYR2	1.76e-06	160	56	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TMPRSS15 HEG1 VWF PRKCH RYR2	2.11e-06	166	56	5	ec719368295133da2f7ff587c5329ed6db1dd56d
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	HEG1 LAMA3 AJUBA LDLR PGBD5	2.59e-06	173	56	5	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5 NOTCH2	3.88e-06	188	56	5	4544552ebd67e9eb3e40d8511bb2b03a6e1178f8
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5 SVEP1	4.09e-06	190	56	5	2f54da2bee411f8868348a4c37034184b8f58a89
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OBSCN OPN5 GRIK1 ITGB5	4.09e-06	190	56	5	be2b184a3559da41ba387ae0fdbeb9ae532868a5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 FBN2 OPN5 GRIK1 ITGB5	4.30e-06	192	56	5	f6ec683b2133b3095a1fcc06ca8605cf38f774b5
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 FBN2 OPN5 GRIK1 ITGB5	4.30e-06	192	56	5	690b3d17c481159bc96b8bc7f6a66b51343ee858
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB6 HEG1 FBN2 GRIK1 ITGB5	4.41e-06	193	56	5	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB6 HEG1 FBN2 GRIK1 ITGB5	4.52e-06	194	56	5	83863da11dfbe59b2d0a2c08db40b537c150588c
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HEG1 FBN2 OPN5 GRIK1 ITGB5	5.25e-06	200	56	5	ca5401b76ab014080914bf78042d368cf318effa
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1--L2-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HEG1 FBN2 OPN5 GRIK1 ITGB5	5.25e-06	200	56	5	70c47d3bbe67d88c5b9dff99c33a603d25fa2ab0
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	EPHB6 HEG1 FBN2 GRIK1 ITGB5	5.25e-06	200	56	5	347a510755374c6a66acee326565dfc447993f18
ToppCell	Neuronal-Inhibitory-iA-iA_2(LAMP5)-CA1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	HEG1 FBN2 OPN5 GRIK1 ITGB5	5.25e-06	200	56	5	40286010bd17cf9e34ecd5440953b072ebfae208
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	SLC25A41 CSRP1 RECK TPH1	4.22e-05	154	56	4	1c62290a2558fd6401b27de5a867d243b143b00a
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	MSTN PTH1R SVEP1 RYR2	4.78e-05	159	56	4	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PJVK NRG2 ITGB5 PGBD5	5.02e-05	161	56	4	7c9d4410d7142a5f3a05418c994f69978c9ffa17
ToppCell	Control-Epithelial_cells-ECM-high_epithelial\|Control / group, cell type (main and fine annotations)	HEG1 VWF LAMA3 LDLR	6.20e-05	170	56	4	e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	OBSCN PTH1R FHL5 RYR2	6.34e-05	171	56	4	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	droplet-Heart-4Chambers-21m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF OBSCN RYR2 TPH1	6.78e-05	174	56	4	f098778ea74012861ec74b425e45776a31f67679
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	6.94e-05	175	56	4	4d42a97c450e919a409477a7db85e2668f0d473b
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-macrophage/monocyte\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PJVK PRKDC NOTCH2	7.41e-05	178	56	4	09d2687e0d79f12e90af35fc1c0453d249cf2d19
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA3 GRIK1 SVEP1 NOTCH2	7.41e-05	178	56	4	2a36475c260088f69f3b8c282d910e5eaa5c5c2d
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN2 VWF LAMA3 NUP160	7.74e-05	180	56	4	baa5825e6ce23a98d9c21d024a4b0ab8ba353d0c
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN2 VWF LAMA3 NUP160	7.74e-05	180	56	4	2d608b9394d28d19cfc85c6ac94003d5177c8a92
ToppCell	facs-Lung-24m-Endothelial-arterial_endothelial\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FBN2 VWF LAMA3 NUP160	7.74e-05	180	56	4	0f9b27054358c4737eed06c8ea01987cccc3cb55
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	LRP2 KIFC3 PTH1R RYR2	7.90e-05	181	56	4	c80ffa2ded5975a88e9a1a7d333196f95237bf0a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	LAMA3 GRIK1 SVEP1 NOTCH2	8.07e-05	182	56	4	d3a037268f026eb2f84428b1821022503cef7756
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 ITGB5 NOTCH2	8.25e-05	183	56	4	f8b636391f752e379a5c5575fd898bdf0907a3b8
ToppCell	Adult-Mesenchymal-pericyte_cell-D122\|Adult / Lineage, Cell type, age group and donor	OBSCN PTH1R FHL5 RYR2	8.25e-05	183	56	4	fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 GRIK1 ITGB5 NOTCH2	8.42e-05	184	56	4	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	megakaryocytic\|World / Lineage and Cell class	VWF KIFC3 ITGB5 RYR2	8.42e-05	184	56	4	b1c630ca2189d9d49402a5621b57618976fbea5c
ToppCell	facs-Bladder-nan-18m\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF EIF5 PGBD5 RYR2	8.60e-05	185	56	4	3e00879466e626aa8604efecfc4678d64f54dbfc
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L6_LAMP5_C1QL2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	8.60e-05	185	56	4	6e7fefdd65d30abaffb26b92b0d04e1630d262ad
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	OBSL1 LAMA3 GRIK1 SVEP1	8.60e-05	185	56	4	0b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCell	facs-Bladder-nan-18m-Epithelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF EIF5 PGBD5 RYR2	8.60e-05	185	56	4	3dc5812c961ff209f197ff4cbfb90009c0537550
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-6_LAMP5_CA13_(Lamp5_Lhx6_1)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	8.78e-05	186	56	4	77592a6397b44b2b59a4fc39d7224dd95343efe6
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OBSCN PTH1R FHL5 RYR2	8.78e-05	186	56	4	888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial-Endo_L2-5_CLDN5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 VWF PRKCH FHL5	8.78e-05	186	56	4	422d24e3e1a9397bb7d5c7ef75de2fd7ae8e136d
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 FBN2 GRIK1 ITGB5	8.78e-05	186	56	4	96f6603cc75fa1ffc2a2fdb94ec0ec09498e540a
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Endo\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 VWF PRKCH FHL5	8.78e-05	186	56	4	65da0666a10a59f8cc379589860a2e98fe487754
ToppCell	Somatosensory_Cortex_(S1)-Non-neuronal-Endothelial_Myeloid-Endo-Endothelial\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 VWF PRKCH FHL5	8.78e-05	186	56	4	dc84fef1ca2f5d5d818b76a3321559e87d1c4a4d
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	OBSCN PTH1R FHL5 RYR2	8.96e-05	187	56	4	86250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCell	Adult-Mesenchymal-pericyte_cell\|Adult / Lineage, Cell type, age group and donor	OBSCN PTH1R FHL5 RYR2	8.96e-05	187	56	4	62759efb660179402fb574ce5701c89a2e17bcfe
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 LRP2 LOXL4 SVEP1	8.96e-05	187	56	4	4e553721fa5598cb211f44e3226280b7e6885484
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 LRP2 LOXL4 SVEP1	8.96e-05	187	56	4	d36e7fc6125e7a4310499365022d38f34b757a73
ToppCell	droplet-Pancreas-Exocrine-18m-Mesenchymal-pancreatic_stellate_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBN2 LRP2 LOXL4 SVEP1	8.96e-05	187	56	4	827eae63fabf6892a82ce7779b5f395958d3d628
ToppCell	facs-Spleen-nan-3m-Lymphocytic-B_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 TRIM25 LRRC58 NOTCH2	8.96e-05	187	56	4	3ca3954f45f167e98a230f2847f0582d74fcd32e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	9.15e-05	188	56	4	8268574584e5fb869a6cb8bbd7135cd7454a6a25
ToppCell	Children_(3_yrs)-Mesenchymal-pericyte_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	OBSCN PTH1R FHL5 RYR2	9.15e-05	188	56	4	ee151792c7ac9afe820f1a281c6dab383799f358
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	9.34e-05	189	56	4	222e67d3fd106c43b0cae6538dddeaa7be1f759f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	9.34e-05	189	56	4	979b7fa947538aa7ca4a219263da2575869a2caa
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF LAMA3 PRKCH	9.34e-05	189	56	4	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	Mesenchymal-pericyte_cell\|World / Lineage, Cell type, age group and donor	OBSCN PTH1R FHL5 RYR2	9.34e-05	189	56	4	d7ed96add29f219183c802895fbff519b627f635
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1\|Hippocampus / BrainAtlas - Mouse McCarroll V32	PRSS16 OBSCN LAMA3	9.42e-05	70	56	3	8d6bdf2e773e894a0db39fdff1fafc2474e03fcf
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	9.53e-05	190	56	4	59720dfe9de1b980807644536c919d2a02ba69dd
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OBSCN PTH1R FHL5 RYR2	9.53e-05	190	56	4	4eb92aef1ee868f4537483d19014d947b7684612
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	VWF PRKCH PTH1R FHL5	9.53e-05	190	56	4	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	nucseq-Mesenchymal-Myocytic-Myocytic_1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OBSCN PTH1R FHL5 RYR2	9.53e-05	190	56	4	7be4341e2909101d756f14031c21e705eb45e69a
ToppCell	ASK454-Mesenchymal\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	HEG1 CSRP1 SVEP1 RYR2	9.73e-05	191	56	4	e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OBSCN PTH1R FHL5 RYR2	9.73e-05	191	56	4	1626b23a57429f835fddc052e3c57f63a4e5b8bb
ToppCell	ASK454-Mesenchymal-Fibroblast\|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq	HEG1 CSRP1 SVEP1 RYR2	9.73e-05	191	56	4	1726add3f392a061536b7aff72ba84303f4a0b1f
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	OBSCN PTH1R FHL5 RYR2	9.73e-05	191	56	4	716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	9.92e-05	192	56	4	342842378c20267c5044bdd622515e8b9f895623
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF LAMA3 PRKCH	9.92e-05	192	56	4	3259cb89d6bcf0a3c6ff1f64d85e8a1f54124e91
ToppCell	facs-Aorta-Heart-3m\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 SF3B1 LAMA3 LRRC58	9.92e-05	192	56	4	1ccc47792edf9ee23501c8e2165d11271636b66a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF LAMA3 PRKCH	9.92e-05	192	56	4	56b021c297a21dff357531f21e2464f85186106d
ToppCell	COPD-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	CSRP1 KIFC3 SVEP1 RYR2	9.92e-05	192	56	4	62904f94dfce430456f05066522cbf9bd29f4d7e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF NRG2 PRKCH	9.92e-05	192	56	4	c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	1.01e-04	193	56	4	294cb5b580bb83fe0eb04f112d5507aac35d4d44
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHB6 HEG1 FBN2 GRIK1	1.01e-04	193	56	4	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CSRP1 ITGB5 PTH1R SVEP1	1.01e-04	193	56	4	b637e1c47a98009e7d19a6daac78f888fd12748f
ToppCell	Megakaryocytic-erythropoietic-Megakaryo-cells-Megakaryocyte\|World / Lineage, cell class and subclass	VWF CSRP1 KIFC3 RYR2	1.01e-04	193	56	4	352cd442b6e62f09b6d22a139774067873644594
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HEG1 PTH1R SVEP1 RYR2	1.01e-04	193	56	4	b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FBN2 OPN5 GRIK1 ITGB5	1.01e-04	193	56	4	3d3c45d5ff6f3396a1990615aae9fe176e799994
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF NRG2 PRKCH	1.01e-04	193	56	4	52e918884877b6659cdca0496390e440f73694a9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	1.03e-04	194	56	4	52aebb0b563e2c2058e7f0554ae870e47692b163
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	HEG1 FHL5 RECK SVEP1	1.03e-04	194	56	4	2260cd817a6661e5eb6645b0c6786e18fd58371e
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	1.03e-04	194	56	4	6ac759828c41ffa974ee82842162caa959351dd1
ToppCell	LV-10._Endothelium_II\|LV / Chamber and Cluster_Paper	HEG1 VWF PRKCH TECTA	1.03e-04	194	56	4	b6cc849fa08599bff9839ef382d190cc964e273e
ToppCell	facs-Heart-RA-3m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC58 ITGB5 PTH1R NOTCH2	1.03e-04	194	56	4	c422aeddb4e949a22f731da675bdf91dee86ba61
ToppCell	nucseq-Mesenchymal-Myocytic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	OBSCN PTH1R FHL5 RYR2	1.03e-04	194	56	4	2d66091097e106c7bee22e5281f50724700bdf8d
ToppCell	E15.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CSRP1 ITGB5 PTH1R SVEP1	1.03e-04	194	56	4	f2f7b9aad7588c8020a4850ff9333e1db8eafac7
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	1.03e-04	194	56	4	5d0b0d8e96f0e0297a4dba70a05d87081a4eb323
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	1.03e-04	194	56	4	bd06e2b8d8c06cddf2e4f58849b86e09013acae1
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 VWF PRKCH LRRC58	1.03e-04	194	56	4	e8102c8811333f04de7280b7d9b6b85cebb815ac
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HEG1 VWF PRKCH LRRC58	1.03e-04	194	56	4	4b0d63babb8a46ff45731d5f82b29ccaf6c9402d
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF LAMA3 PRKCH	1.05e-04	195	56	4	6bdef651cf73d7381e5012d0eb3c809138fb6b92
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	HEG1 VWF LAMA3 PRKCH	1.05e-04	195	56	4	d35102f95bb1e419d2df05ff0a01b6c5c923acef
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L1-4_LAMP5_DUSP4_(Lamp5_Rosehip)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HEG1 OPN5 GRIK1 ITGB5	1.05e-04	195	56	4	98ca9f3aa36211dde1e6f7f3817b9418c95e583e
ToppCell	droplet-Limb_Muscle-nan-18m-Mesenchymal-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXL4 MSTN ITGB5 SVEP1	1.07e-04	196	56	4	fcb275746bf51269ed8ba4cf93edb054a45f1ccd
ToppCell	Parenchymal-NucSeq-Stromal-Pericyte-Muscle_pericyte_pulmonary\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	OBSCN PTH1R FHL5 RYR2	1.10e-04	197	56	4	f66945f9007d59d4208849c7fd727f8519713fbc
Computational	Genes in the cancer module 27.	EPHB6 TMPRSS15 LRP2 PRKCH GRIK1 ITGB5 LDLR PTH1R	2.18e-05	355	37	8	MODULE_27
Drug	rosiglitazone; Down 200; 10uM; HL60; HT_HG-U133A	EPHB6 RAD52 MCM3AP KLHDC10 CAMSAP2 NOTCH2 RYR2	5.85e-07	200	56	7	6192_DN
Drug	raloxifene	VWF TRIM25 EIF5 NRG2 PRKDC MSTN LDLR TPH1	2.20e-06	351	56	8	CID000005035
Drug	Monensin sodium salt [22373-78-0]; Up 200; 5.8uM; PC3; HT_HG-U133A	AARS1 TMPRSS15 NRG2 IL17RC KIFC3 LDLR	5.78e-06	183	56	6	3704_UP
Drug	monacolin X	EPHB6 LDLR	5.94e-06	2	56	2	CID000125978
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYLD KIF21B HEG1 MCM3AP OBSL1 GRIK1	7.61e-06	192	56	6	3332_UP
Drug	Isoflupredone acetate [338-98-7]; Down 200; 9.6uM; MCF7; HT_HG-U133A	RAD52 TMPRSS15 HEG1 LRP2 NOTCH2 RYR2	9.07e-06	198	56	6	5545_DN
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; HL60; HT_HG-U133A	CYLD HEG1 FBN2 KLHDC10 LDLR NUP160	9.07e-06	198	56	6	2346_DN
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; PC3; HT_HG-U133A	CYLD TMPRSS15 HEG1 FBN2 RECK RYR2	9.33e-06	199	56	6	5781_DN
Drug	5-methoxytryptophol	LOXL4 TECTA TPH1	2.10e-05	22	56	3	CID000012835
Drug	verapamil	EPHB6 VWF TRIM25 TRPA1 PRKCH MSTN LDLR RYR2	2.49e-05	490	56	8	CID000002520
Drug	Rgd Peptide	FBN2 VWF LAMA3 OPN5 ITGAE ITGB5	2.63e-05	239	56	6	CID000104802
Drug	N-methyl-DL-aspartic acid	TRIM25 TRPA1 NRG2 OPN5 PRKCH GRIK1 TECTA LDLR RYR2	2.89e-05	655	56	9	CID000004376
Drug	AR 12456	EPHB6 LDLR	3.55e-05	4	56	2	CID000127644
Drug	AR 12465	EPHB6 LDLR	3.55e-05	4	56	2	CID000127645
Drug	AC1L1FCE	TMPRSS15 LDLR	3.55e-05	4	56	2	CID000003176
Drug	Verteporfin [129497-78-5]; Down 200; 2.8uM; MCF7; HT_HG-U133A	MCM3AP LAMA3 TMEM131 LDLR NOTCH2	3.96e-05	155	56	5	6817_DN
Drug	dichloromethanediamine	BIRC8 NAIP LRP2 LOXL4 PRKCH PRKDC AJUBA POLR1H	4.90e-05	539	56	8	CID005311048
Drug	AR 12463	EPHB6 LDLR	5.91e-05	5	56	2	CID000119335
Drug	ronipamil	EPHB6 LDLR	5.91e-05	5	56	2	CID000065638
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT_HG-U133A	CYLD KIF21B HEG1 OBSL1 PGBD5	8.05e-05	180	56	5	3510_UP
Drug	NSC-725021	BIRC8 NAIP	8.86e-05	6	56	2	CID000406741
Drug	1m2r	TRIM25 TECTA NOTCH2	9.50e-05	36	56	3	CID000085466
Drug	Diphenylpyraline hydrochloride [132-18-3]; Down 200; 12.6uM; PC3; HT_HG-U133A	PRKCH IL17RC PRKDC LDLR NOTCH2	1.06e-04	191	56	5	4299_DN
Drug	Hesperidin [520-26-3]; Down 200; 6.6uM; PC3; HT_HG-U133A	TRIM25 EIF5 PRKDC NUP160 NOTCH2	1.09e-04	192	56	5	6714_DN
Drug	Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; PC3; HT_HG-U133A	TRIM25 IL17RC PRKDC KLHDC10 NOTCH2	1.12e-04	193	56	5	6704_DN
Drug	Moroxidine hydrochloride [3160-91-6]; Down 200; 19.2uM; PC3; HT_HG-U133A	RAD52 PRKDC KLHDC10 NUP160 NOTCH2	1.15e-04	194	56	5	6705_DN
Drug	Betamethasone [378-44-9]; Up 200; 10.2uM; MCF7; HT_HG-U133A	EPHB6 RAD52 HEG1 TRIM25 SVEP1	1.15e-04	194	56	5	5328_UP
Drug	Sulindac [38194-50-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	HEG1 TRIM25 PRKCH PRKDC NOTCH2	1.17e-04	195	56	5	1815_UP
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A	CYLD RAD52 LRP2 IL17RC RYR2	1.17e-04	195	56	5	5399_DN
Drug	Fluorometholone [426-13-1]; Up 200; 10.6uM; MCF7; HT_HG-U133A	CYLD KIF21B LRP2 GRIK1 KIFC3	1.17e-04	195	56	5	6071_UP
Drug	Mephenytoin [50-12-4]; Up 200; 18.4uM; HL60; HT_HG-U133A	HEG1 MCM3AP NRG2 PRKCH IL17RC	1.20e-04	196	56	5	6158_UP
Drug	alpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A	RAD52 LRP2 KLHDC10 ITGB5 NOTCH2	1.20e-04	196	56	5	1151_UP
Drug	Timolol maleate salt [26921-17-5]; Down 200; 9.2uM; MCF7; HT_HG-U133A	RAD52 LRP2 PRKCH IL17RC SVEP1	1.20e-04	196	56	5	5280_DN
Drug	Benzthiazide [91-33-8]; Down 200; 9.2uM; MCF7; HT_HG-U133A	CYLD MCM3AP PRKCH LDLR NOTCH2	1.20e-04	196	56	5	3329_DN
Drug	Thioproperazine dimesylate [2347-80-0]; Up 200; 6.2uM; PC3; HT_HG-U133A	TRIM25 NRG2 KIFC3 KLHDC10 LDLR	1.20e-04	196	56	5	2073_UP
Drug	Cefadroxil [50370-12-2]; Up 200; 11uM; MCF7; HT_HG-U133A	CYLD RAD52 HEG1 IL17RC RYR2	1.20e-04	196	56	5	3259_UP
Drug	PF-00539745-00 [351321-33-0]; Up 200; 10uM; MCF7; HT_HG-U133A	RAD52 LRP2 PRKCH LDLR NOTCH2	1.23e-04	197	56	5	5974_UP
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; MCF7; HT_HG-U133A	TRIM25 MTF1 EIF5 IL17RC NUP160	1.23e-04	197	56	5	6275_DN
Drug	C75; Down 200; 10uM; PC3; HT_HG-U133A	CYLD TMPRSS15 FBN2 PRSS16 KIFC3	1.23e-04	197	56	5	6428_DN
Drug	haloperidol; Up 200; 10uM; MCF7; HT_HG-U133A	RAD52 PRSS16 EIF5 LDLR PGBD5	1.23e-04	197	56	5	7003_UP
Drug	Minoxidil [38304-91-5]; Up 200; 19.2uM; MCF7; HT_HG-U133A	TMPRSS15 ZIM2 LRP2 PRKCH NOTCH2	1.23e-04	197	56	5	4800_UP
Drug	Mephenytoin [50-12-4]; Down 200; 18.4uM; PC3; HT_HG-U133A	TMPRSS15 HEG1 FBN2 RECK RYR2	1.23e-04	197	56	5	5801_DN
Drug	Gly-(asp)(4)-lys-2-na	EPHB6 TMPRSS15	1.24e-04	7	56	2	CID000172458
Drug	HMS2232N07	TMPRSS15 ITGAE	1.24e-04	7	56	2	CID000072111
Drug	Cyclopenthiazide [742-20-1]; Up 200; 10.6uM; HL60; HT_HG-U133A	HEG1 FBN2 EFCAB6 LRP2 KIFC3	1.26e-04	198	56	5	2905_UP
Drug	(+,-)-Octopamine hydrochloride [770-05-8]; Up 200; 21uM; MCF7; HT_HG-U133A	RAD52 KIF21B OBSL1 IL17RC ITGB5	1.26e-04	198	56	5	5469_UP
Drug	Methiothepin maleate [19728-88-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A	CYLD TRIM25 PRSS16 LRP2 RYR2	1.26e-04	198	56	5	3231_DN
Drug	(S)-(-)-Atenolol [93379-54-5]; Down 200; 15uM; MCF7; HT_HG-U133A	RAD52 LAMA3 LDLR PGBD5 RYR2	1.26e-04	198	56	5	6444_DN
Drug	Methacholine chloride [62-51-1]; Down 200; 20.4uM; PC3; HT_HG-U133A	CYLD TMPRSS15 TRIM25 RECK RYR2	1.29e-04	199	56	5	5773_DN
Drug	Sulfamethoxazole [723-46-6]; Up 200; 15.8uM; PC3; HT_HG-U133A	CYLD RAD52 FBN2 IL17RC PTH1R	1.29e-04	199	56	5	7366_UP
Drug	Cefalonium [5575-21-3]; Up 200; 8.8uM; HL60; HT_HG-U133A	TMPRSS15 LRP2 GRIK1 IL17RC TPH1	1.29e-04	199	56	5	2921_UP
Drug	Aspartic acid, N-acetyl (R,S) [997-55-7]; Up 200; 22.8uM; MCF7; HT_HG-U133A	KIF21B HEG1 LRP2 IL17RC RYR2	1.29e-04	199	56	5	3265_UP
Drug	Flecainide acetate [54143-56-5]; Up 200; 8.4uM; MCF7; HT_HG-U133A	TRIM25 PRSS16 MCM3AP KIFC3 SVEP1	1.32e-04	200	56	5	3418_UP
Drug	desogestrel	VWF TRIM25 OPN5 LDLR	1.35e-04	106	56	4	CID000040973
Drug	Rgds Peptide	VWF LAMA3 OPN5 ITGB5	1.35e-04	106	56	4	CID000107775
Drug	eicosane	LAMA3 ITGAE LDLR TPH1	1.40e-04	107	56	4	CID000008222
Drug	pyrachlostrobin	HEG1 TRIM25 CSRP1 LRP2 GRIK1 AJUBA ITGB5 SVEP1 NOTCH2	1.49e-04	811	56	9	ctd:C513428
Drug	5 alpha-cholest-8(14)-en-3 beta-ol-15-one	EPHB6 LDLR	1.65e-04	8	56	2	CID000039756
Drug	lamotrigine	TRPA1 LOXL4 GRIK1 RYR2	1.92e-04	116	56	4	CID000003878
Drug	EGFR inhibitor	TRIM25 NRG2 MSTN PTH1R	2.18e-04	120	56	4	CID009549299
Drug	Trp-Trp	LDLR PTH1R RYR2	2.40e-04	49	56	3	CID000088656
Disease	scoliosis (is_implicated_in)	FBN2 TPH1	1.97e-05	4	54	2	DOID:0060249 (is_implicated_in)
Disease	migraine without aura, susceptibility to, 4, diastolic blood pressure	ITGB5 FHL5	6.86e-05	7	54	2	EFO_0006336, MONDO_0011847
Disease	pulse pressure measurement, migraine without aura, susceptibility to, 4	ITGB5 FHL5	1.17e-04	9	54	2	EFO_0005763, MONDO_0011847
Disease	Proteinuria	VWF LRP2	3.40e-04	15	54	2	HP_0000093
Disease	migraine disorder, systolic blood pressure	ITGB5 FHL5	4.94e-04	18	54	2	EFO_0006335, MONDO_0005277
Disease	attention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia	KIF21B GRIK1 POLR1H	8.51e-04	101	54	3	EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Disease	migraine disorder, diastolic blood pressure	ITGB5 FHL5	9.60e-04	25	54	2	EFO_0006336, MONDO_0005277
Disease	migraine disorder, pulse pressure measurement	ITGB5 FHL5	1.04e-03	26	54	2	EFO_0005763, MONDO_0005277
Disease	Glioblastoma Multiforme	EPHB6 RECK NOTCH2	1.12e-03	111	54	3	C1621958
Disease	lung small cell carcinoma (is_implicated_in)	RAD52 LAMA3	1.21e-03	28	54	2	DOID:5409 (is_implicated_in)
Disease	Squamous cell carcinoma	RAD52 PRKDC NOTCH2	1.54e-03	124	54	3	C0007137
Disease	Colorectal Carcinoma	EPHB6 FBN2 MCM3AP OBSCN LRP2 CAMSAP2	1.74e-03	702	54	6	C0009402
Disease	cervical cancer	CYLD NOTCH2	1.78e-03	34	54	2	C4048328

Protein segments in the cluster

Peptide	Gene	Start	Entry
FYFTGVKSGIQCFCC	NAIP	86	Q13075
YLFSGFQEAAEKCCV	AJUBA	391	Q96IF1
DIEQAFCFFYGLQCK	GRIK1	866	P39086
VDLNNGKFYVGVCAF	RAD52	96	P43351
YFCVQGCKLGEASDF	RECK	521	O95980
EFQCVAGDECAYFTV	OBSL1	876	O75147
GFKGYNCQVNIDECA	NOTCH2	786	Q04721
YACANFGEQGVTVGC	LOXL4	656	Q96JB6
NTAGVNCEQCAKGYY	LAMA3	396	Q16787
FALEKSNYFGCQGCQ	LAMA3	671	Q16787
NYEKINCNFEDGFCF	TMPRSS15	341	P98073
KGVFCASEAEFQGYN	MCM3AP	796	O60318
GVCQKTVYFAEEVQC	CSRP1	11	P21291
CFECNFALVQYGGVI	ITGAE	236	P38570
CVQIKNDVFICGGYN	KLHDC10	321	Q6PID8
TCVSKLIEGCFEGYN	KIF21B	66	O75037
NETAKSYCVNGGVCY	NRG2	346	O14511
YQVIDYKFACCQTGG	OPN5	306	Q6U736
GCAVVTCQQGYFKCQ	LRP2	61	P98164
GVALCQCKSGYFQFN	HEG1	1196	Q9ULI3
NQCSCFESEFGKIYG	ITGB5	531	P18084
CGGVYFDCCVRQIKF	LRRC58	301	Q96CX6
AGCYTCQVSNKFGQV	OBSCN	4966	Q5VST9
LFEEFEKQGIYCCGL	PGBD5	351	Q8N414
ESGNYCVPCFEKEFA	FHL5	146	Q5TD97
YFGCELGAQTQFDVK	EIF5	56	P55010
AGFYAIGQEDKVQCF	BIRC8	26	Q96P09
NGKFAYCDFIQSCVL	EFCAB6	1376	Q5THR3
FNEIGSFKCLCNEGY	FBN2	1991	P35556
FTDGVYQGKQLFQCD	CYLD	176	Q9NQC7
YQGKQLFQCDEDCGV	CYLD	181	Q9NQC7
TKCFICGIGNDYFDT	RYR2	4886	Q92736
EQFDDDQKVCCGFFF	CAMSAP2	1151	Q08AD1
QFGQSVGSVVYDCFE	IL17RC	221	Q8NAC3
CIDGFNVCIFAYGQT	KIFC3	516	Q9BVG8
GEYTFVCNQEGCGKA	MTF1	166	Q14872
GLECYQDNFSKFGLC	EPHB6	961	O15197
ANYCSGECEFVFLQK	MSTN	306	O14793
DEGQTVFYTCTNCKF	POLR1H	106	Q9P1U0
KFSVFEQCKNYFCGI	SLC25A41	166	Q8N5S1
EVGSKVQFFCNEGYE	SVEP1	2281	Q4LDE5
CYLVTGEGQKALECF	NUP160	916	Q12769
GDVYCFNKTCGSGEV	TECTA	681	O75443
CYFFTVEFGLCKQDG	TPH1	311	P17752
SIFGYCKEAGQIFQQ	TRPA1	781	O75762
QTYQEKVCGLCGNFD	VWF	986	P04275
NFKRETVYGCFQCSV	PJVK	316	Q0ZLH3
TVYGCFQCSVDGQKY	PJVK	321	Q0ZLH3
TGQECGVVLDKTCFY	AARS1	521	P49588
QGFFVAIIYCFCNGE	PTH1R	451	Q03431
VVKQCCGTDGVEANY	SF3B1	791	O75533
VELQKNNFCGVGICY	TRIM25	516	Q14258
CEGYGFKVVNCQEFT	TMEM131	1041	Q92545
VICCVFNELKFYQGF	PRKDC	1951	P78527
YFECFQCGKAFLQNV	ZIM2	411	Q9NZV7
QTCTEFGFYVTCENP	PRSS16	376	Q9NQE7
GENVYECSDCGKVFS	ZNF891	456	A8MT65
LEGGYKCQCEEGFQL	LDLR	371	P01130
FGKQGYQCQVCTCVV	PRKCH	196	P24723