Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	beta-adrenergic receptor kinase activity	GRK2 GRK6	2.84e-05	4	44	2	GO:0047696
GeneOntologyMolecularFunction	G protein-coupled receptor kinase activity	GRK2 GRK6	9.90e-05	7	44	2	GO:0004703
GeneOntologyMolecularFunction	lipoteichoic acid binding	DMBT1 NLRP6	9.90e-05	7	44	2	GO:0070891
Domain	GPCR_kinase	GRK2 GRK6	9.81e-05	7	41	2	IPR000239
Domain	DAPIN	NLRP13 NLRP6	1.06e-03	22	41	2	PS50824
Domain	DAPIN	NLRP13 NLRP6	1.06e-03	22	41	2	IPR004020
Domain	PYRIN	NLRP13 NLRP6	1.06e-03	22	41	2	SM01289
Domain	PYRIN	NLRP13 NLRP6	1.06e-03	22	41	2	PF02758
Domain	NACHT	NLRP13 NLRP6	1.16e-03	23	41	2	PS50837
Domain	NACHT_NTPase	NLRP13 NLRP6	1.16e-03	23	41	2	IPR007111
Domain	HECT	HECW1 UBR5	1.59e-03	27	41	2	PF00632
Domain	HECTc	HECW1 UBR5	1.59e-03	27	41	2	SM00119
Domain	HECT_dom	HECW1 UBR5	1.59e-03	27	41	2	IPR000569
Domain	HECT	HECW1 UBR5	1.59e-03	27	41	2	PS50237
Domain	RGS	GRK2 GRK6	2.67e-03	35	41	2	PF00615
Domain	RGS	GRK2 GRK6	2.67e-03	35	41	2	SM00315
Domain	Sc_DH/Rdtase_CS	DHRSX RDH13	2.67e-03	35	41	2	IPR020904
Domain	RGS	GRK2 GRK6	2.83e-03	36	41	2	PS50132
Domain	RGS	GRK2 GRK6	3.31e-03	39	41	2	IPR016137
Domain	ADH_SHORT	DHRSX RDH13	6.04e-03	53	41	2	PS00061
Domain	adh_short	DHRSX RDH13	6.49e-03	55	41	2	PF00106
Domain	LRR_6	LRRC14 NLRP13	6.49e-03	55	41	2	PF13516
Domain	SDR_fam	DHRSX RDH13	6.72e-03	56	41	2	IPR002347
Domain	AGC-kinase_C	GRK2 GRK6	6.72e-03	56	41	2	IPR000961
Domain	AGC_KINASE_CTER	GRK2 GRK6	6.72e-03	56	41	2	PS51285
Domain	S_TK_X	GRK2 GRK6	6.72e-03	56	41	2	SM00133
Pubmed	Cardiopulmonary bypass decreases G protein-coupled receptor kinase activity and expression in human peripheral blood mononuclear cells.	GRK2 GRK6	1.56e-06	2	44	2	12552191
Pubmed	G protein-coupled receptor kinase-5 regulates thrombin-activated signaling in endothelial cells.	GRK2 GRK6	1.56e-06	2	44	2	10861009
Pubmed	Natural history of cone disease in the murine model of Leber congenital amaurosis due to CEP290 mutation: determining the timing and expectation of therapy.	NRL CEP290	1.56e-06	2	44	2	24671090
Pubmed	A CEP290 C-Terminal Domain Complements the Mutant CEP290 of Rd16 Mice In Trans and Rescues Retinal Degeneration.	NRL CEP290	1.56e-06	2	44	2	30332642
Pubmed	Expression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium.	GRK2 GRK6	4.69e-06	3	44	2	10467231
Pubmed	Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy.	NRL CEP290	4.69e-06	3	44	2	21245082
Pubmed	Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).	GRK2 GRK6	4.69e-06	3	44	2	18662895
Pubmed	Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor.	GRK2 GRK6	9.37e-06	4	44	2	10379886
Pubmed	G-protein receptor kinases 2, 5 and 6 redundantly modulate Smoothened-GATA transcriptional crosstalk in fetal mouse hearts.	GRK2 GRK6	9.37e-06	4	44	2	29969579
Pubmed	Knock-out mice reveal the contributions of P2Y and P2X receptors to nucleotide-induced Ca2+ signaling in macrophages.	GRK2 GRK6	9.37e-06	4	44	2	16980298
Pubmed	Reduced expression of G protein-coupled receptor kinases in schizophrenia but not in schizoaffective disorder.	GRK2 GRK6	9.37e-06	4	44	2	21784156
Pubmed	Quantification of Oxygen Consumption in Retina Ex Vivo Demonstrates Limited Reserve Capacity of Photoreceptor Mitochondria.	NRL CEP290	9.37e-06	4	44	2	26747773
Pubmed	The chemokine receptors CXCR1 and CXCR2 couple to distinct G protein-coupled receptor kinases to mediate and regulate leukocyte functions.	GRK2 GRK6	9.37e-06	4	44	2	22869904
Pubmed	Low nociceptor GRK2 prolongs prostaglandin E2 hyperalgesia via biased cAMP signaling to Epac/Rap1, protein kinase Cepsilon, and MEK/ERK.	GRK2 GRK6	9.37e-06	4	44	2	20861385
Pubmed	Aberrantly expressed recoverin is functionally associated with G-protein-coupled receptor kinases in cancer cell lines.	GRK2 GRK6	1.56e-05	5	44	2	12507501
Pubmed	G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel.	GRK2 GRK6	1.56e-05	5	44	2	17102134
Pubmed	beta-Arrestin-biased agonism of the angiotensin receptor induced by mechanical stress.	GRK2 GRK6	2.34e-05	6	44	2	20530803
Pubmed	beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein.	GRK2 GRK6	2.34e-05	6	44	2	9826657
Pubmed	Phosphorylation and desensitization of human endothelin A and B receptors. Evidence for G protein-coupled receptor kinase specificity.	GRK2 GRK6	2.34e-05	6	44	2	9211925
Pubmed	Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.	GRK2 GRK6	2.34e-05	6	44	2	36451830
Pubmed	The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.	GRK2 GRK6	2.34e-05	6	44	2	10506199
Pubmed	Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes.	GRK2 GRK6	2.34e-05	6	44	2	17060617
Pubmed	Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.	GRK2 GRK6	3.27e-05	7	44	2	8672451
Pubmed	Determination of bradykinin B2 receptor in vivo phosphorylation sites and their role in receptor function.	GRK2 GRK6	3.27e-05	7	44	2	11517230
Pubmed	The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity.	NRXN1 SDCBP2	4.36e-05	8	44	2	11152476
Pubmed	Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK.	CXCL13 CCR10	5.60e-05	9	44	2	10706668
Pubmed	Toll-like receptors differentially regulate GPCR kinases and arrestins in primary macrophages.	GRK2 GRK6	5.60e-05	9	44	2	18180038
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TRPM4 LRRC14 PLEC ZBTB42 SYNE4 NBEAL2 GRK6 INTS1	6.49e-05	1105	44	8	35748872
Pubmed	Synucleins are a novel class of substrates for G protein-coupled receptor kinases.	GRK2 GRK6	6.99e-05	10	44	2	10852916
Pubmed	The genetics of NOD-like receptors in Crohn's disease.	NLRP13 NLRP6	1.41e-04	14	44	2	20403135
Pubmed	NALPs: a novel protein family involved in inflammation.	NLRP13 NLRP6	1.41e-04	14	44	2	12563287
Pubmed	Ciliopathy-associated IQCB1/NPHP5 protein is required for mouse photoreceptor outer segment formation.	NRL CEP290	1.86e-04	16	44	2	27328943
Pubmed	System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes.	HECW1 UBR5	4.99e-04	26	44	2	26949039
Pubmed	New genetic associations detected in a host response study to hepatitis B vaccine.	CXCL13 CCR10 PDE4C HAL ALDH3B1 NLRP6	5.69e-04	824	44	6	20237496
Pubmed	Genome-scale RNAi screen for host factors required for HIV replication.	LRRC14 GRK2 UBR5 NBEAL2	1.12e-03	361	44	4	18976975
Pubmed	Orphan quality control shapes network dynamics and gene expression.	NRL UBR5	1.13e-03	39	44	2	37478862
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	MAG TRPM4 RDH13 GRIK5 SYNE4 NLRP13	9.19e-04	1192	44	6	chr19q13
GeneFamily	Pyrin domain containing\|Pyrin and HIN domain family	NLRP13 NLRP6	8.88e-04	25	32	2	994
GeneFamily	NLR family	NLRP13 NLRP6	8.88e-04	25	32	2	666
ToppCell	Severe-Myeloid-Mast-\|Severe / Condition, Lineage, Cell class and cell subclass	MAG GRIK5 PDE4C AARD	1.27e-05	145	44	4	ce307d45425a5191882078f049f85477eec40b69
ToppCell	Severe-Myeloid-Mast\|Severe / Condition, Lineage, Cell class and cell subclass	MAG GRIK5 PDE4C AARD	1.27e-05	145	44	4	e0bfd2ffdbd6c197ef0a04e983396ebd87ef7127
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-Treg-Treg_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CCR10 PIMREG PDE4C SDCBP2	1.87e-05	160	44	4	8308ca6f37986c526432a0fbc5f7ec2e75cfb6d7
ToppCell	21-Trachea-Epithelial-Submucosal_gland\|Trachea / Age, Tissue, Lineage and Cell class	WDR74 TRPM4 DMBT1 NDRG2	2.84e-05	178	44	4	3e406e38eea0d38dc25edecf703c4c89ec6a28e0
ToppCell	ICU-NoSEP-Myeloid-tDC\|ICU-NoSEP / Disease, Lineage and Cell Type	MAG ATP8B3 TRPM4 GPC3	2.97e-05	180	44	4	be665e801512f6aaf6b3ecb26153bbdeb24619ac
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B3 GPC3 NRXN1 PRRT3	3.44e-05	187	44	4	2591fe1552cd10925ad1d8d1f062a057ce6bdad9
ToppCell	droplet-Heart-nan-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP8B3 GPC3 NRXN1 PRRT3	3.44e-05	187	44	4	59313a47a6012b2413d7d3673bb05fb7e49fd88f
ToppCell	Smart-seq2-blood_(Smart-seq2)-myeloid\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PLEC GRK2 ALDH3B1 NBEAL2	3.90e-05	193	44	4	1db487e5f81849740d57cc3e2b5739e8f7581efb
ToppCell	Tracheal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Serous\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC14 HAL DMBT1 AARD	4.48e-05	200	44	4	61bae10c8b12196d9cee766897971b81cb897191
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6\|Thalamus / BrainAtlas - Mouse McCarroll V32	TFAP2D LMX1A NLRP6	4.76e-05	71	44	3	7623b110bc3db0f5b99803c8fbb881ae8846b817
Computational	Genes in the cancer module 41.	MAG GRIK5 PDE4C HAL DMBT1 NRXN1 NDRG2	1.71e-04	566	24	7	MODULE_41
Drug	Gallamine triethiodide [65-29-2]; Down 200; 4.4uM; MCF7; HT_HG-U133A	LRRC14 GRIK5 PLEC GRK2 IFI35 GRK6	1.91e-06	194	44	6	2221_DN
Disease	Leber congenital amaurosis (implicated_via_orthology)	DHRSX RDH13 CEP290	7.59e-07	13	42	3	DOID:14791 (implicated_via_orthology)
Disease	histidine measurement	HAL NDRG2 GRK6	1.15e-04	66	42	3	EFO_0009769
Disease	Adenocarcinoma of large intestine	GRK2 UBR5 TBCK	3.49e-04	96	42	3	C1319315
Disease	Parkinson's disease (biomarker_via_orthology)	GRK2 GRK6	8.39e-04	30	42	2	DOID:14330 (biomarker_via_orthology)
Disease	platelet measurement	RDH13 PLEC NBEAL2 GRK6	1.04e-03	315	42	4	EFO_0005036
Disease	Cataract	NDRG2 INTS1	1.28e-03	37	42	2	C0086543

Protein segments in the cluster

Peptide	Gene	Start	Entry
FRRCRERISQGLQGL	AARD	6	Q4LEZ3
QDGQREGQRRCRLIF	CCR10	181	P46092
FQRLRALLGCGRVAI	ALDH3B1	291	P43353
CAELLLRFGARVDGR	ASB10	196	Q8WXI3
IGNLLLRGCRIRNTD	ATP8B3	331	O60423
EGLLQRDVNRRLGCL	GRK2	426	P25098
GGRCLREKLDRLGLN	TFAP2D	261	Q7Z6R9
RCELAARLERAGLNG	SPACA5	26	Q96QH8
QGRSRLLGDLGLRNC	MAG	86	P20916
GDSVLGRRCRDLLLQ	INTS1	1791	Q8N201
ECLRGARRDLKVFGN	GPC3	196	P51654
AALRGSNGLRRFCIE	HECW1	1546	Q76N89
LGFARDGVAQRLCQI	IFI35	181	P80217
EGCQRVILDRFLLRL	LMX1A	36	Q8TE12
RFDLENGLSCGRRAL	PDE4C	81	Q08493
NRQLRGCGRDEALRL	NRL	146	P54845
GQLRVLLAFRRGQGC	LCN10	76	Q6JVE6
CDFLELILTRGGRLQ	NRXN1	76	Q9ULB1
GALGSLCRQFQRRLP	PIMREG	41	Q9BSJ6
RFIDRIQILPRGNGC	CXCL13	46	O43927
LELARRGGNIILACR	RDH13	56	Q8NBN7
RRCKGLGLLDNEDRL	HAL	56	P42357
GGRDTRFLRNEICQL	CEP290	106	O15078
ILAQLLRRCRGGFLE	DHRSX	21	Q8N5I4
CGRGERLALALAREQ	GRIK5	36	Q16478
LCERQPIGRLLFREF	GRK6	56	P43250
LALRLVNGGDRCQGR	DMBT1	361	Q9UGM3
LALRLVNGGDRCQGR	DMBT1	991	Q9UGM3
VRDSVFQRCGLRGLA	PRRT3	826	Q5FWE3
DLRNLCRLAREGVLG	NLRP6	441	P59044
LQNLRGGRICLHDIR	FTH1P19	36	P0C7X4
LCLLGLGRRLQDLEQ	SYNE4	111	Q8N205
LCLVLEFARGGALNR	MAP3K21	196	Q5TCX8
RDLNFERGGDITLRC	NDRG2	241	Q9UN36
SRQRLRLRECGLQGL	NBEAL2	1196	Q6ZNJ1
LRFGDQLLQIDGRDC	SDCBP2	146	Q9H190
LAEIDLRQGRLLGCL	WDR74	251	Q6RFH5
QLLRRCRRDDGTGQL	PLEC	3996	Q15149
LRDRLLANGFNECIL	TBCK	666	Q8TEA7
LGRLRQQRELGFLCD	ZBTB42	11	B2RXF5
DFCRQGRLLLSLGDE	TTC34	466	A8MYJ7
GCLGGENRFRLRLES	TRPM4	241	Q8TD43
LNCFRNIGRILGLCL	UBR5	2526	O95071
LLDAGCLRRVDLRFN	LRRC14	216	Q15048
TRLCLGFNRLQDDGI	NLRP13	841	Q86W25